keyword
MENU ▼
Read by QxMD icon Read
search

Osteosarcoma

keyword
https://www.readbyqxmd.com/read/27936316/bioprospecting-of-turbinaria-macroalgae-as-a-potential-source-of-health-protective-compounds
#1
Milena Stranska-Zachariasova, Isma Kurniatanty, Helena Gbelcova, Monika Jiru, Josep Rubert, Tjokorda Gde Tirta Nindhia, Cosimo Walter D'Acunto, Sony Heru Sumarsono, Marselina Irasonia Tan, Jana Hajslova, Tomas Ruml
The present study aims to focus on the bioprospecting of marine macroalgae of Turbinaria species, plenteous biomass of the world ocean. Three types of solvents, i.e. water, methanol:water (80:20, v/v) and hexane:isopropanol (50:50, v/v), were used for extraction. Both the biological activity, as well as the pattern of present chemicals were characterized. For the cell proliferation assay, the human embryonic kidney 293 cells, cervix / breast / pancreatic adenocarcinoma, and osteosarcoma cells were used. For the antioxidant activity determination, both intracellular assay with human embryonic kidney and cervix adenocarcinoma cells, as well as the biochemical DPPH test, were employed...
December 9, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27935335/pediatric-chondromyxoid-fibroma-like-osteosarcoma
#2
Matthew Stark, Stephen D Heinrich, Raju Sivashanmugam, Dane Mackey, Ewa Wasilewska, Randall Craver
Chondromyxoid fibroma-like osteosarcoma (CMF-OS) is a low-grade osteosarcoma, often misdiagnosed on initial biopsy as a benign lesion, with five cases previously described. We report a 13-year-old male with an intramedullary lytic CMF-OS of the right tibial proximal metaphysis with cortical destruction and soft tissue extension. Diagnosis was based on malignant new bone formation, increased mitotic figures, lamellar bone permeation with bony destruction, and correlation with imaging studies. There were no metastasis at presentation and the tumor showed good response to standard chemotherapy with >95% necrosis...
December 9, 2016: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/27933467/osteosarcoma-overview
#3
REVIEW
Brock A Lindsey, Justin E Markel, Eugenie S Kleinerman
Osteosarcoma (OS) is the most common primary malignancy of bone and patients with metastatic disease or recurrences continue to have very poor outcomes. Unfortunately, little prognostic improvement has been generated from the last 20 years of research and a new perspective is warranted. OS is extremely heterogeneous in both its origins and manifestations. Although multiple associations have been made between the development of osteosarcoma and race, gender, age, various genomic alterations, and exposure situations among others, the etiology remains unclear and controversial...
December 8, 2016: Rheumatology and Therapy
https://www.readbyqxmd.com/read/27933253/primary-intracerebral-osteosarcoma-a-rare-case-report-and-review
#4
Song-Ping Chen, Jin-Long Tang, Xiu-Liang Zhu
BACKGROUND: Primary intracranial osteosarcoma is a extremely rare disease entity. We describe a case of primary intracerebral osteosarcoma in an adult brain. CASE DESCRIPTION: A patient who presented with a 1-week history of headaches, and MRI examination was performed. The immunohistochemical diagnosis confirmed primary intracerebral osteosarcoma. The patient was treated with a surgical resection of the tumor. CONCLUSION: Primary osteosarcomas occurring in the brain are extremely rare...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27933061/ncr1-expression-identifies-canine-natural-killer-cell-subsets-with-phenotypic-similarity-to-human-natural-killer-cells
#5
Jennifer A Foltz, Srinivas S Somanchi, Yanwen Yang, Arianexys Aquino-Lopez, Erin E Bishop, Dean A Lee
Canines spontaneously develop many cancers similar to humans - including osteosarcoma, leukemia, and lymphoma - offering the opportunity to study immune therapies in a genetically heterogeneous and immunocompetent environment. However, a lack of antibodies recognizing canine NK cell markers has resulted in suboptimal characterization and unknown purity of NK cell products, hindering the development of canine models of NK cell adoptive immunotherapy. To this end, we generated a novel antibody to canine NCR1 (NKp46), the putative species-wide marker of NK cells, enabling purification of NK cells for further characterization...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27931832/the-role-of-the-igf-1-ec-in-myoskeletal-system-and-osteosarcoma-pathophysiology
#6
REVIEW
Nikolaos Armakolas, Athanasios Armakolas, Athanasios Antonopoulos, Andreas Dimakakos, Martha Stathaki, Michael Koutsilieris
Growth hormone (GH) regulated mainly liver-produced insulin-like growth factor 1 (IGF-1) is a key molecule in embryonic & post embryonic development that is also involved in cancer biology. Herein we review new insights of the role of igf-1 gene products and of the IGF-1Ec isoform in muscle and bone development/repair and its role in osteosarcoma pathophysiology, underlying the possible role of the Ec peptide as a future therapeutic target.
December 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/27931795/ikk%C3%AE-inibition-by-a-glucosamine-derivative-enhances-maspin-expression-in-osteosarcoma-cell-line
#7
Martina Leopizzi, Rossana Cocchiola, Edoardo Milanetti, Domenico Raimondo, Laura Politi, Cesare Giordano, Roberto Scandurra, Anna Scotto d'Abusco
Chronic inflammation has been associated to cancer development by the alteration of several inflammatory pathways, such as Nuclear Factor-κB pathway. In particular, IκB kinase α (IKKα), one of two catalytic subunit of IKK complex, has been described to be associated to cancer progression and metastasis in a number of cancers. The molecular mechanism by which IKKα affects cancer progression is not yet completely clarified, anyway an association between IKKα and the expression of Maspin (Mammary Serine Protease Inhibitor or SerpinB5), a tumor suppressor protein, has been described...
December 5, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27931212/pdgf-aa-mediates-mesenchymal-stromal-cell-chemotaxis-to-the-head-and-neck-squamous-cell-carcinoma-tumor-microenvironment
#8
Tammara L Watts, Ruwen Cui, Peter Szaniszlo, Vicente A Resto, Don W Powell, Irina V Pinchuk
BACKGROUND: The robust desmoplasia associated with head and neck squamous cell carcinoma (HNSCC) suggests that the tumor microenvironment may be an important component in the pathophysiology of this cancer. Moreover, the high recurrence rate and poor clinical response to chemotherapy and radiation treatment further underscores that the non-cancerous cells of the microenvironment, such as mesenchymal stromal cells (MSCs), cancer associated fibroblasts (CAFs), and pericytes, may be important in the pathophysiology of HNSCC...
December 8, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27930982/targeted-osteosarcoma-chemotherapy-using-rgd-peptide-installed-doxorubicin-loaded-biodegradable-polymeric-micelle
#9
Zhenhua Fang, Yanpeng Sun, Hong Xiao, Peng Li, Ming Liu, Fan Ding, Wusheng Kan, Runsheng Miao
Osteosarcoma is the most common primary malignant bone tumor in the pediatric age group, and chemotherapy directed by targeted nanoparticulate drug delivery system represents a promising approach for osteosarcoma treatment recently. Here, we designed and developed a novel DOX-loaded targeted polymeric micelle self-assembled from RGD-terminated poly(ethylene glycol)-block-poly (trimethylene carbonate) (RGD-PEG-PTMC) amphiphilic biodegradable block copolymer, for high-efficiency targeted chemotherapy of osteosarcoma...
December 5, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27929439/cell-death-in-chondrocytes-osteoblasts-and-osteocytes
#10
REVIEW
Toshihisa Komori
Cell death in skeletal component cells, including chondrocytes, osteoblasts, and osteocytes, plays roles in skeletal development, maintenance, and repair as well as in the pathogenesis of osteoarthritis and osteoporosis. Chondrocyte proliferation, differentiation, and apoptosis are important steps for endochondral ossification. Although the inactivation of P53 and RB is involved in the pathogenesis of osteosarcomas, the deletion of p53 and inactivation of Rb are insufficient to enhance chondrocyte proliferation, indicating the presence of multiple inhibitory mechanisms against sarcomagenesis in chondrocytes...
December 6, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27929143/effect-of-unplanned-therapy-on-the-prognosis-of-patients-with-extremity-osteosarcoma
#11
Bing Wang, Ming Xu, Kai Zheng, Xiuchun Yu
Unplanned therapy for extremity osteosarcoma can result in erroneous surgical procedures and lack of neoadjuvant chemotherapy before the first operation. Our aim was to compare the prognosis between patients with extremity osteosarcoma who received unplanned therapy and those who received standard treatment. This was a retrospective review of patients with extremity osteosarcoma who received appropriate surgical treatment and neoadjuvant chemotherapy (n = 79) and those who received unplanned therapy (n = 24) between June 2000 and October 2014...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27925440/enhancing-bioactive-properties-of-silk-fibroin-with-diatom-particles-for-bone-tissue-engineering-applications
#12
Thi Duy Hanh Le, Volha Liaudanskaya, Walter Bonani, Claudio Migliaresi, Antonella Motta
Many studies have highlighted the role of silicon in human bone formation and maintenance. Silicon, in fact, is considered to nucleate the precipitation of hydroxyapatite and to reduce the bone resorption. For this reason, we have combined silk fibroin with silicon releasing diatom particles, as potential material for bone tissue engineering applications. Sponges of fibroin loaded with different amounts and sizes of diatom particles were prepared by solvent casting-particulate leaching method, and their morphology, porosity and mechanical properties were evaluated...
December 7, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27923594/synthesis-of-the-cyp24a1-major-metabolite-of-2%C3%AE-2-tetrazol-2-yl-ethyl-1%C3%AE-25-dihydroxyvitamin-d3
#13
REVIEW
Masashi Takano, Kaori Yasuda, Eri Tohyama, Erika Higuchi, Toshiyuki Sakaki, Atsushi Kittaka
Previously, we found that 2α-[2-(tetrazol-2-yl)ethyl]-1α,25-dihydroxyvitamin D3 (AH-1) showed higher osteocalcin promoter transactivation activity in human osteosarcoma (HOS) cells and a greater therapeutic effect on ovariectomized (OVX) rats for enhancing bone mineral density than those of 1α,25(OH)2D3 without hypercalcemic side effects in vivo. Although CYP24A1 catalyzes multi-step oxidations toward the CD-ring side chain of the active vitamin D3 [1α,25(OH)2D3], the CYP24A1-dependent metabolism of AH-1 tended to stop at the first step hydroxylation at the C24-position of AH-1...
December 3, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27922953/total-maxillary-reconstruction-with-a-bi-paddle-double-barrel-osteocutaneous-fibular-flap-and-arteriovenous-saphenous-loop-after-a-globe-sparing-total-maxillectomy-due-to-osteosarcoma
#14
Wan-Ling Tseng, Tzu-Yen Chang, Kuo-Shu Hung, Szu-Han Chen, Jenn-Ren Hsiao, Yao-Chou Lee
BACKGROUND: The titanium mesh or bone graft is usually used for orbital support after a globe-sparing total maxillectomy. However, its use can invite complications, such as infection, exposure, and absorption, especially for patients who require adjuvant radiotherapy. Here, the authors present a patient who received total maxillary reconstruction with an osteocutaneous fibular flap. METHODS: A 53-year-old man with the diagnosis of maxillary osteosarcoma received a globe-sparing total maxillectomy...
December 5, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27922432/mir-21-predicts-poor-prognosis-in-patients-with-osteosarcoma
#15
Xianfeng Ren, Yuqin Shen, Shuyun Zheng, JianYong Liu, Xin Jiang
BACKGROUND AND AIMS: miR-21 has been demonstrated to play an important role in tumour progression. The aim of the present study was to analyse the correlation between miR-21 expression level and clinicopathologic features, as well as to assess the prognostic significance of miR-21 in osteosarcoma. METHODS: Eighty-four pairs of osteosarcoma and corresponding non-cancerous bone tissues were obtained, and miR-21 expression levels were detected using quantitative real-time PCR (qRT-PCR)...
October 2016: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/27920865/recurrent-radiation-induced-osteosarcoma-of-the-sternum-in-a-patient-with-remote-radiation-therapy-for-breast-cancer
#16
Joseph M Limback, Haley P Letter, Kurt F Scherer, Christopher W Wasyliw, Laura W Bancroft
BACKGROUND: Recurrent radiation-induced osteosarcoma of the sternum following remote radiation therapy for breast cancer and sternal reconstruction. CASE: A 51-year-old woman presents with recurrent, radiation-induced sternal osteosarcoma 11 years after receiving both radiation therapy for breast cancer and sternal reconstruction. The case details both her work-up and subsequent course, including reconstructive and curative efforts. DISCUSSION: An uncommon side effect of radiation therapy for breast cancer is development of osteosarcoma of the chest wall...
December 2016: Radiology case reports
https://www.readbyqxmd.com/read/27920692/effects-of-arsenic-trioxide-on-minor-progressive-high-grade-osteosarcoma-of-the-extremities-metastatic-to-the-lung-results-of-39-patients-treated-in-a-single-institution
#17
Lu Xie, Wei Guo, Xiaodong Tang, Yi Yang, Jie Xu
Patients who mildly progressed after first-line chemotherapy were administered arsenic trioxide (ATO) 5-10 mg intravenously daily. Thirty-nine patients were finally enrolled in the study, of whom 19 patients received first-line chemotherapy with ATO infusion while 20 patients did not. Progression-free survival at 4 months was 89.2 and 62.7% (p = 0.043) for the ATO group and the control group, respectively, while the 2-year overall survival was 61 and 16.4% (p = 0.032).
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27920558/monitoring-the-effects-of-doxorubicin-on-3d-spheroid-tumor-cells-in-real-time
#18
NamHuk Baek, Ok Won Seo, MinSung Kim, John Hulme, Seong Soo A An
Recently, increasing numbers of cell culture experiments with 3D spheroids presented better correlating results in vivo than traditional 2D cell culture systems. 3D spheroids could offer a simple and highly reproducible model that would exhibit many characteristics of natural tissue, such as the production of extracellular matrix. In this paper numerous cell lines were screened and selected depending on their ability to form and maintain a spherical shape. The effects of increasing concentrations of doxorubicin (DXR) on the integrity and viability of the selected spheroids were then measured at regular intervals and in real-time...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27919658/quinolizinium-as-a-new-fluorescent-lysosomotropic-probe
#19
Emmanouil Zacharioudakis, Tatiana Cañeque, Raúl Custodio, Sebastian Müller, Ana M Cuadro, Juan J Vaquero, Raphaël Rodriguez
We have synthesized a collection of quinolizinium fluorescent dyes for the purpose of cell imaging. Preliminary biological studies in human U2OS osteosarcoma cancer cells have shown that different functional groups appended to the cationic quinolizinium scaffold efficiently modulate photophysical properties but also cellular distribution. While quinolizinium probes are known nuclear staining reagents, we have identified a particular quinolizinium derivative salt that targets the lysosomal compartment. This finding raises the question of predictability of specific organelle targeting from structural features of small molecules...
November 24, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27919267/targeted-drug-delivery-of-near-ir-fluorescent-doxorubicin-conjugated-poly-ethylene-glycol-bisphosphonate-nanoparticles-for-diagnosis-and-therapy-of-primary-and-metastatic-bone-cancer-in-a-mouse-model
#20
S Rudnick-Glick, E Corem-Salkmon, I Grinberg, S Margel
BACKGROUND: Most primary and metastatic bone tumors demonstrate increased osteoclast activity and bone resorption. Current treatment is based on a combination of surgery, radiotherapy and chemotherapy. Severe side effects are associated with chemotherapy due to use of high dosage and nonspecific uptake. Bisphosphonates have a strong affinity to Ca(2+) ions and are widely used in the treatment of bone disorders. RESULTS: We have engineered a unique biodegradable bisphosphonate nanoparticle (NPs) bearing two functional surface groups: (1) primary amine groups for covalent attachment of a dye/drug (e...
December 5, 2016: Journal of Nanobiotechnology
keyword
keyword
5346
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"