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https://www.readbyqxmd.com/read/28327506/efficacy-and-safety-evaluation-of-a-chlorine-dioxide-solution
#1
Jui-Wen Ma, Bin-Syuan Huang, Chu-Wei Hsu, Chun-Wei Peng, Ming-Long Cheng, Jung-Yie Kao, Tzong-Der Way, Hao-Chang Yin, Shan-Shue Wang
In this study, a chlorine dioxide solution (UC-1) composed of chlorine dioxide was produced using an electrolytic method and subsequently purified using a membrane. UC-1 was determined to contain 2000 ppm of gaseous chlorine dioxide in water. The efficacy and safety of UC-1 were evaluated. The antimicrobial activity was more than 98.2% reduction when UC-1 concentrations were 5 and 20 ppm for bacteria and fungi, respectively. The half maximal inhibitory concentrations (IC50) of H1N1, influenza virus B/TW/71718/04, and EV71 were 84...
March 22, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28303920/the-golgi-protein-acbd3-facilitates-enterovirus-71-replication-by-interacting-with-3a
#2
Xiaobo Lei, Xia Xiao, Zhenzhen Zhang, Yijie Ma, Jianli Qi, Chao Wu, Yan Xiao, Zhuo Zhou, Bin He, Jianwei Wang
Enterovirus 71 (EV71) is a human pathogen that causes hand, foot, mouth disease and neurological complications. Although EV71, as well as other enteroviruses, initiates a remodeling of intracellular membrane for genomic replication, the regulatory mechanism remains elusive. By screening human cDNA library, we uncover that the Golgi resident protein acyl-coenzyme A binding domain-containing 3 (ACBD3) serves as a target of the 3A protein of EV71. This interaction occurs in cells expressing 3A or infected with EV71...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28262332/report-from-the-world-health-organization-s-third-product-development-for-vaccines-advisory-committee-pdvac-meeting-geneva-8-10th-june-2016
#3
Birgitte K Giersing, Johan Vekemans, Samantha Nava, David C Kaslow, Vasee Moorthy
The third meeting of WHO's Product Development for Vaccines Advisory Committee (PDVAC) was held in June 2016, with a remit to revisit the pathogen areas for which significant progress has occurred since recommendations from the 2015 meeting, as well as to consider new advances in the development of vaccines against other pathogens. Since the previous meeting, significant progress has been made with regulatory approvals of the first malaria and dengue vaccines, and the first phase III trials of a respiratory syncytial virus (RSV) vaccine candidate has started in the elderly and pregnant women...
March 2, 2017: Vaccine
https://www.readbyqxmd.com/read/28248924/microrna-screening-identifies-mir-134-as-a-regulator-of-poliovirus-and-enterovirus-71-infection
#4
Nichole Lynn Orr-Burks, Byoung-Shik Shim, Weilin Wu, Abhijeet A Bakre, Jon Karpilow, Ralph A Tripp
MicroRNAs (miRNAs) regulate virus replication through multiple mechanisms. Poliovirus causes a highly debilitating disease and though global efforts to eradicate polio have sharply decreased polio incidence, unfortunately three countries (Afghanistan, Nigeria and Pakistan) remain polio-endemic. We hypothesize that understanding the host factors involved in polio replication will identify novel prophylactic and therapeutic targets against polio and related viruses. In this data set, employing genome wide screens of miRNA mimics and inhibitors, we identified miRNAs which significantly suppressed polio replication...
March 1, 2017: Scientific Data
https://www.readbyqxmd.com/read/28236071/recombinant-heat-shock-protein-78-enhances-enterovirus-71-propagation-in-vero-cells-and-is-induced-in-sk-n-sh-cells-during-the-infection
#5
Bing Zhu, Tiantian Xu, Zhengfang Lin, Changbing Wang, Yinghua Li, Mingqi Zhao, Liang Hua, Misi Xiao, Ning Deng
Enterovirus 71 (EV71) is one of the major causative agents of hand, foot and mouth disease (HFMD), which mainly occurs in children. Children with EV71 infection can develop severe neurological diseases. Heat shock protein 78 (HSP78) facilitates proper protein folding during viral propagation and is induced during virus infection. Nevertheless, the role that HSP78 plays during EV71 infection is still unclear. In this study, recombinant HSP78 protein was expressed in a prokaryotic expression system and used for exploring the interaction between HSP78 and EV71 propagation...
February 24, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28220872/human-enterovirus-71-protein-interaction-network-prompts-antiviral-drug-repositioning
#6
Lu Han, Kang Li, Chaozhi Jin, Jian Wang, Qingjun Li, Qiling Zhang, Qiyue Cheng, Jing Yang, Xiaochen Bo, Shengqi Wang
As a predominant cause of human hand, foot, and mouth disease, enterovirus 71 (EV71) infection may lead to serious diseases and result in severe consequences that threaten public health and cause widespread panic. Although the systematic identification of physical interactions between viral proteins and host proteins provides initial information for the recognition of the cellular mechanism involved in viral infection and the development of new therapies, EV71-host protein interactions have not been explored...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28217559/a-novel-enterovirus-71-ev71-virulence-determinant-the-69th-residue-of-3c-protease-modulates-pathogenicity
#7
Bingqing Li, Yingying Yue, Yajie Zhang, Zenglin Yuan, Peng Li, Nannan Song, Wei Lin, Yan Liu, Lichuan Gu, Hong Meng
Human enterovirus type 71 (EV71), the major causative agent of hand-foot-and-mouth disease, has been known to cause fatal neurological complications. Unfortunately, the reason for neurological complications that have been seen in fatal cases of the disease and the relationship between EV71 virulence and viral genetic sequences remains largely undefined. The 3C protease (3C(pro)) of EV71 plays an irreplaceable role in segmenting the precursor polyprotein during viral replication, and intervening with host life activity during viral infection...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28214745/rapid-detection-and-quantification-of-enterovirus-71-by-a-portable-surface-plasmon-resonance-biosensor
#8
Briliant Adhi Prabowo, Robert Y L Wang, Muhammad Khari Secario, Po-Ting Ou, Azharul Alom, Jia-Jung Liu, Kou-Chen Liu
This study presents the first report on a label-free detection and rapid quantification method for human enterovirus 71 (EV71) using a portable surface plasmon resonance (SPR) system. The SPR sensor instrument was configured to run on low power in a miniaturized platform to improve the device portability for a wider application both in laboratories and in the field. A color tunable organic light emitting diode in red spectrum was attached on a trapezoidal prism for the disposable light source module. The SPR signal processing using integration area under the reflectivity curve is applied for optimum signal to noise ratio (SNR) enhancement...
June 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28198671/transcriptome-analysis-reveals-dynamic-changes-in-coxsackievirus-a16-infected-hek-293t-cells
#9
Jun Jin, Rujiao Li, Chunlai Jiang, Ruosi Zhang, Xiaomeng Ge, Fang Liang, Xin Sheng, Wenwen Dai, Meili Chen, Jiayan Wu, Jingfa Xiao, Weiheng Su
BACKGROUND: Coxsackievirus A16 (CVA16) and enterovirus 71 (EV71) are two of the major causes of hand, foot and mouth disease (HFMD) world-wide. Although many studies have focused on infection and pathogenic mechanisms, the transcriptome profile of the host cell upon CVA16 infection is still largely unknown. RESULTS: In this study, we compared the mRNA and miRNA expression profiles of human embryonic kidney 293T cells infected and non-infected with CVA16. We highlighted that the transcription of SCARB2, a cellular receptor for both CVA16 and EV71, was up-regulated by nearly 10-fold in infected cells compared to non-infected cells...
January 25, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28168168/enterovirus-71-infection-and-vaccines
#10
REVIEW
Eun-Je Yi, Yun-Ju Shin, Jeong-Hwan Kim, Tae-Gyun Kim, Sun-Young Chang
Hand, foot and mouth disease (HFMD) is a highly contagious viral infection affecting young children during the spring to fall seasons. Recently, serious outbreaks of HFMD were reported frequently in the Asia-Pacific region, including China and Korea. The symptoms of HFMD are usually mild, comprising fever, loss of appetite, and a rash with blisters, which do not need specific treatment. However, there are uncommon neurological or cardiac complications such as meningitis and acute flaccid paralysis that can be fatal...
January 2017: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/28150210/an-ultrasensitive-biosensing-platform-employing-acetylcholinesterase-and-gold-nanoparticles
#11
Dingbin Liu, Xiaoyuan Chen
Enzyme-linked immunosorbent assay (ELISA) is a well-known strategy for biomarker detection with a color change, which can be seen by the naked eyes. However, the moderate sensitivity of conventional ELISA limits its applications in many cases where the concentrations of biomarker are very low, such as cancer diagnosis. Here we describe an ultrasensitive colorimetric assay based on acetylcholinesterase (AChE)-catalyzed hydrolysis reaction, whose products trigger the aggregation of gold nanoparticles (AuNPs), causing a distinct color change of the solution from red to purple...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28141506/antiviral-activity-of-acid-beta-glucosidase-1-on-enterovirus-71-a-causative-agent-of-hand-foot-mouth-disease
#12
Keiko Nakata, Satoshi Takeda, Atsushi Tanaka, Jimmy Kwang, Jun Komano
Enterovirus 71 (EV71) is a causative agent of hand-foot-mouth disease (HFMD). EV71 causes fever, rash, diarrhea, and, in some cases, acute encephalopathy/encephalitis, which can be fatal. No specific treatment is currently available for EV71 infection. Here, we conducted a cDNA library screen and identified acid β-glucosidase 1 (GBA1; also known as β-glucocerebrosidase) as an EV71 resistance factor. The anti-EV71 function of GBA1 was verified by gene transduction and knockdown experiments. Cerezyme, a molecular drug used to treat Gaucher's disease having recombinant human GBA1 as the active ingredient, protected against EV71 infection...
January 27, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28137842/enteroviruses-infect-human-enteroids-and-induce-antiviral-signaling-in-a-cell-lineage-specific-manner
#13
Coyne G Drummond, Alexa M Bolock, Congrong Ma, Cliff J Luke, Misty Good, Carolyn B Coyne
Enteroviruses are among the most common viral infectious agents of humans and are primarily transmitted by the fecal-oral route. However, the events associated with enterovirus infections of the human gastrointestinal tract remain largely unknown. Here, we used stem cell-derived enteroids from human small intestines to study enterovirus infections of the intestinal epithelium. We found that enteroids were susceptible to infection by diverse enteroviruses, including echovirus 11 (E11), coxsackievirus B (CVB), and enterovirus 71 (EV71), and that contrary to an immortalized intestinal cell line, enteroids induced antiviral and inflammatory signaling pathways in response to infection in a virus-specific manner...
February 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28108327/structurally-diverse-secondary-metabolites-from-a-deep-sea-derived-fungus-penicillium-chrysogenum-scsio-41001-and-their-biological-evaluation
#14
Shengtian Chen, Junfeng Wang, Zhen Wang, Xiuping Lin, Bingxin Zhao, Kumaravel Kaliaperumal, Xiaojian Liao, Zhengchao Tu, Jianlin Li, Shihai Xu, Yonghong Liu
Five new compounds, including a cytotoxic dimeric isocoumarin, bipenicilisorin (1), a merosesquiterpenoid, yaminterritrem C (2), a citrinin dimer, penicitrinone F (3), a alkaloid, terremide D (4), and a δ-valerolacton, (E)-4-(propen-1-yl)-5,6-dihydro-2H-pyran-2-one (5), along with ten known compounds (6-15) were isolated from a deep-sea-derived fungus Penicillium chrysogenum SCSIO 41001. Their structures and absolute configurations were elucidated by NMR spectra, MS, CD, optical rotation, X-ray crystallography, and compared with literature data...
March 2017: Fitoterapia
https://www.readbyqxmd.com/read/28101327/hsa-let-7c-5p-augments-enterovirus-71-replication-through-viral-subversion-of-cell-signaling-in-rhabdomyosarcoma-cells
#15
Bingfei Zhou, Min Chu, Shanshan Xu, Xiong Chen, Yongjuan Liu, Zhihao Wang, Fengfeng Zhang, Song Han, Jun Yin, Biwen Peng, Xiaohua He, Wanhong Liu
BACKGROUND: Human enterovirus 71 (EV71) causes severe hand, foot and mouse disease, accompanied by neurological complications. During the interaction between EV71 and the host, the virus subverts host cell machinery for its own replication. However, the roles of microRNAs (miRNAs) in this process remain obscure. RESULTS: In this study, we found that the miRNA hsa-let-7c-5p was significantly upregulated in EV71-infected rhabdomyosarcoma cells. The overexpression of hsa-let-7c-5p promoted replication of the virus, and the hsa-let-7c-5p inhibitor suppressed viral replication...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/28100320/-association-of-tlr3-1377c-t-gene-polymorphisms-and-expression-with-susceptibility-to-enterovirus-71-encephalitis-in-children
#16
Ai-Yun Yuan, Hong-Fang He, Fu-Yan Lyu, Pei-Pei Liu, Jing-Fei Hu, Zong-Bo Chen
OBJECTIVE: To investigate the association of gene polymorphisms of Toll-like receptor 3 (TLR3)-1377C/T and expression of TLR3 with the susceptibility to enterovirus 71 (EV71) encephalitis in children. METHODS: A total of 187 children with EV71 infection (59 children in the encephalitis group and 128 in the non-encephalitis group) and 232 children who underwent physical examination were enrolled in the case-control study. Polymerase chain reaction-restriction fragment length polymorphism was used to detect the TLR3-1377C/T gene polymorphisms...
January 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28077584/2-year-efficacy-immunogenicity-and-safety-of-vigoo-enterovirus-71-vaccine-in-healthy-chinese-children-a-randomized-open-label-study
#17
Mingwei Wei, Fanyue Meng, Shiyuan Wang, Jingxin Li, Yuntao Zhang, Qunying Mao, Yuemei Hu, Pei Liu, Nianmin Shi, Hong Tao, Kai Chu, Yuxiao Wang, Zhenglun Liang, Xiuling Li, Fengcai Zhu
BACKGROUND:  This study evaluated the 2-year efficacy, immunogenicity, and safety of the Vigoo enterovirus 71 (EV71) vaccine. METHOD:  In an initial phase 3 study, we randomly assigned healthy infants and children aged 6-35 months (ratio, 1:1) to receive 2 doses of either EV71 vaccine (5120 participants) or placebo (5125 participants) at days 0 and 28, and followed them for 12 months after vaccination. In this extended follow-up study, we continued to evaluate the efficacy, immunogenicity, and safety of the EV71 vaccine for up to 2 years...
January 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28064293/epidemiological-and-clinical-features-of-enteroviral-acute-lower-respiratory-tract-infections-in-hospitalized-paediatric-patients-in-a-malaysian-tertiary-center
#18
J W Y Tan, R Nuryasmin, Y Apandi, V Nethiya, H Hussin, A L Zuraidah
BACKGROUND: Human enteroviruses (HEVs) have been recognized to cause a significant number of respiratory tract infections in many regions. Previous studies conducted to analyse enteroviral respiratory tract infections focused on outbreaks. Data in the Southeast Asian region is still rather limited to date. OBJECTIVES: We conducted a prospective analysis to understand the epidemiological characteristics of enteroviral lower respiratory tract infections (LRTIs) among paediatric patients admitted to Hospital Ampang, a tertiary hospital in Malaysia...
October 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28063993/inhibition-of-enterovirus-71-replication-by-an-%C3%AE-hydroxy-nitrile-derivative-nk-1-9k
#19
Yaxin Wang, Lin Cao, Yangyang Zhai, Jiaming Ma, Quandeng Nie, Ting Li, Zheng Yin, Yuna Sun, Luqing Shang
Enterovirus 71 (EV71) is one of the major etiological agents of human hand-foot-and-mouth disease (HFMD) worldwide. EV71 infection in young children and people with immunodeficiency causes severe symptoms with a high fatality rates. However, there is still no approved drugs to treat such infections. Based on our previous report of a peptide-aldehyde anti-EV71 protease, we present here a highly specific α-hydroxy-nitrile derivative NK-1.9k, which inhibited the proliferation of multiple EV71 strains and coxsackievirus A16 (CVA16) in various cells with EC50 of 37...
January 5, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28060938/ev71-3d-protein-binds-with-nlrp3-and-enhances-the-assembly-of-inflammasome-complex
#20
Wenbiao Wang, Feng Xiao, Pin Wan, Pan Pan, Yecheng Zhang, Fang Liu, Kailang Wu, Yingle Liu, Jianguo Wu
Activation of NLRP3 inflammasome is important for effective host defense against invading pathogen. Together with apoptosis-associated speck-like protein containing CARD domain (ASC), NLRP3 induces the cleavage of caspase-1 to facilitate the maturation of interleukin-1beta (IL-1β), an important pro-inflammatory cytokine. IL-1β subsequently plays critical roles in inflammatory responses by activating immune cells and inducing many secondary pro-inflammatory cytokines. Although the role of NLRP3 inflammasome in immune response is well defined, the mechanism underlying its assembly modulated by pathogen infection remains largely unknown...
January 2017: PLoS Pathogens
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