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Atherosclerotic stenosis

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https://www.readbyqxmd.com/read/27908353/the-risk-continuum-of-atherosclerosis-and%C3%A2-its-implications-for-defining-chd-by%C3%A2-coronary-angiography
#1
REVIEW
Armin Arbab-Zadeh, Valentin Fuster
Patients undergoing coronary angiography for suspected coronary heart disease who are found to have coronary atherosclerotic disease with <50% diameter stenosis may carry a risk of adverse cardiac events similar to that in patients with single-vessel obstructive disease. Yet clinical practice guidelines offer no direction for managing symptomatic patients with nonobstructive coronary atherosclerosis because current diagnostic criteria for coronary heart disease are not met. Accordingly, secondary preventive measures are not endorsed, and their role is not defined in this setting...
December 6, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27908279/co-existing-intracranial-and-extracranial-carotid-artery-atherosclerotic-plaques-and-recurrent-stroke-risk-a-three-dimensional-multicontrast-cardiovascular-magnetic-resonance-study
#2
Yilan Xu, Chun Yuan, Zechen Zhou, Le He, Donghua Mi, Rui Li, Yuanyuan Cui, Yilong Wang, Yongjun Wang, Gaifen Liu, Zhuozhao Zheng, Xihai Zhao
BACKGROUND: As a systemic disease, atherosclerosis commonly affects intracranial and extracranial carotid arteries simultaneously which is defined as co-existing plaques. Previous studies demonstrated that co-existing atherosclerotic diseases are significantly associated with ischemic cerebrovascular events. The aim of this study was to investigate the characteristics of co-existing intracranial and extracranial carotid atherosclerotic plaques and their relationships with recurrent stroke by using 3D multi-contrast magnetic resonance (MR) vessel wall imaging...
December 2, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27905030/involvement-of-the-coronary-bed-in-patients-with-coronary-heart-disease-against-the-background-of-primarily-coronary-and-generalized-atherosclerosis
#3
M A Bakarev, A A Karpova, V I Pichigin, D B Nikityuk, E L Lushnikova
Significant associations between clinical history factors, lipid metabolism parameters, and type of atherosclerotic process (area of vascular lesions and severity of clinical manifestations) were detected. The predominance of generalized atherosclerosis in chronic coronary heart disease group was associated with patients' age, more incident excessive body weight and type 2 diabetes mellitus, and more severe course of arterial hypertension. Increased lipid spectrum atherogenicity was significantly more often observed in generalized atherosclerosis in the myocardial infarction group...
December 1, 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27904523/the-role-of-near-infrared-spectroscopy-in-the-detection-of-vulnerable-atherosclerotic-plaques
#4
Martin Horvath, Petr Hajek, Cyril Stechovsky, Jakub Honek, Miloslav Spacek, Josef Veselka
Coronary artery disease is the leading cause of mortality worldwide. Most acute coronary syndromes are caused by a rupture of a vulnerable atherosclerotic plaque which can be characterized by a lipid-rich necrotic core with an overlying thin fibrous cap. Many vulnerable plaques can cause angiographically mild stenoses due to positive remodelling, which is why the extent of coronary artery disease may be seriously underestimated. In recent years, we have witnessed a paradigm shift in interventional cardiology...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27899854/association-of-neutrophil-to-lymphocyte-ratio-with-the-severity-and-morphology-of-coronary-atherosclerotic-plaques-detected-by-multidetector-computerized-tomography
#5
Ahmet Hakan Ateş, Kudret Aytemir, Duygu Koçyiğit, Muhammed Ulvi Yalcin, Kadri Murat Gürses, Hikmet Yorgun, Uğur Canpolat, Tuncay Hazırolan, Necla Özer
BACKGROUND: Studies have demonstrated a consistent relationship between white blood cell (WBC) counts and coronary artery disease (CAD). The neutrophil/lymphocyte ratio (NLR) has been considered as a potential marker for identifying individuals under risk of CAD and associated events. In this study, we aimed to evaluate whether NLR was associated with the severity and morphology of coronary atherosclerotic plaques shown by multidetector computed tomography (MDCT). METHODS: Our study population consisted of 684 patients who underwent dual-source 64 slice MDCT for the assessment of CAD...
November 2016: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/27895035/microrna-210-enhances-fibrous-cap-stability-in-advanced-atherosclerotic-lesions
#6
Suzanne M Eken, Hong Jin, Ekaterina Chernogubova, Yuhuang Li, Nancy Simon, Changyan Sun, Greg Korzunowicz, Albert Busch, Alexandra Bäcklund, Cecilia Österholm, Anton Razuvaev, Thomas Renné, Hans-Henning Eckstein, Jaroslav Pelisek, Per Eriksson, Maria Gonzalez Diez, Ljubica P Matic Perisic, Isabel N Schellinger, Uwe Raaz, Nicholas J Leeper, Göran K Hansson, Gabrielle Paulsson-Berne, Ulf Hedin, Lars Maegdefessel
RATIONALE: In the search for markers and modulators of vascular disease, miRNAs have emerged as potent therapeutic targets. OBJECTIVE: To investigate miRNAs of clinical interest in patients with unstable carotid stenosis at risk of stroke. METHODS AND RESULTS: Utilizing patient material from the Biobank of Karolinska Endarterectomies (BiKE), we profiled miRNA expression in patients with stable vs unstable carotid plaque. A PCR-based miRNA array of plasma, sampled at the carotid lesion site, identified eight deregulated miRNAs (miR-15b, -29c, -30c/d, -150, -191, -210 and -500)...
November 28, 2016: Circulation Research
https://www.readbyqxmd.com/read/27887845/-management-of-atherosclerotic-renal-artery-stenosis-in-2016
#7
Thomas Fournier, Florence Sens, Olivier Rouvière, Antoine Millon, Laurent Juillard
Endovascular revascularization as treatment of atherosclerotic renal-artery stenosis (aRAS) is controversial since 3 large and multicentric randomised trials (CORAL, ASTRAL, STAR) failed to prove the superiority of percutaneous transluminal renal-artery stenting (PTRAS) over medical treatment only (MT). However, considering the multiple bias of these trials, among which questionable inclusion criterias, these results must be extrapolated in clinical practice with caution. New pathophysiological data have been helping to understand why restoring blood flow does not necessarily lead to kidney function improvement...
November 22, 2016: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/27887791/cryptogenic-stroke-and-nonstenosing-intracranial-calcified-atherosclerosis
#8
Hooman Kamel, Gino Gialdini, Hediyeh Baradaran, Ashley E Giambrone, Babak B Navi, Michael P Lerario, James K Min, Costantino Iadecola, Ajay Gupta
OBJECTIVE: Because some cryptogenic strokes may result from large-artery atherosclerosis that goes unrecognized as it causes <50% luminal stenosis, we compared the prevalence of nonstenosing intracranial atherosclerotic plaques ipsilateral to cryptogenic cerebral infarcts versus the unaffected side using imaging biomarkers of calcium burden. METHODS: In a prospective stroke registry, we identified patients with cerebral infarction limited to the territory of one internal carotid artery (ICA)...
November 23, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27881360/an-observational-registry-of-carotid-endarterectomy-and-carotid-artery-stenting-in-brazil-study-protocol
#9
Edwaldo Edner Joviliano, Winston Bonetti Yoshida, Marcone Lima Sobreira, Regina Moura, Ana Terezinha Guillaumon, Selma Regina De Oliveira Raymundo, Daniel Gustavo Miquelin, Ludvig Hafner, Marcelo Jose Almeida
BACKGROUND: Carotid artery stenting (CAS) and carotid endarterectomy (CEA) are alternative strategies for stroke prevention in patients with atherosclerotic carotid disease. CEA has been considered the first-line treatment for carotid stenosis worldwide, and the safety and efficacy of CAS compared to CEA remains in question. OBJECTIVE: The purpose of this study is to compare the practice and outcomes of CAS and CEA in a real-world setting within public university hospitals in Brazil...
November 23, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27873231/atherosclerotic-renal-artery-stenosis
#10
Robert Schoepe, Stephen McQuillan, Debbie Valsan, Geoffrey Teehan
Atherosclerotic Renal Artery Stenosis is a form or peripheral arterial disease that tends to affect older subjects with hyperlipidemia, history of tobacco use, and who have other coexistent forms of vascular insufficiency. An abdominal bruit on physical exam can be a helpful clue. Slowly progressive, it can lead to critical narrowing of the renal arteries which creates a cascade of events such as renin-angiotensin-aldosterone activation (RAAS), hypertension, acute pulmonary edema, and renal fibrosis. The hypertension is considered a secondary form and can even be resistant to multiple antihypertensives...
November 22, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27872233/effects-of-percutaneous-transluminal-renal-angioplasty-on-office-and-home-blood-pressure-and-home-blood-pressure-variability-in-hypertensive-patients-with-renal-artery-stenosis
#11
Yoshio Iwashima, Tetsuya Fukuda, Hiroshi Kusunoki, Shin-Ichiro Hayashi, Masatsugu Kishida, Fumiki Yoshihara, Satoko Nakamura, Kei Kamide, Takeshi Horio, Yuhei Kawano
This study included 126 hypertensive patients with renal artery stenosis (mean age, 63 years; 22.2% fibromuscular dysplasia [FMD]) and investigated the effects of percutaneous transluminal renal angioplasty on office and home blood pressure (BP), and BP variability estimates derived from home BP, both at baseline and up to 12 months after angioplasty. Home BP was measured for 7 consecutive days, and the threshold defining uncontrolled home BP was ≥135/85 mm Hg. In both the FMD and atherosclerotic stenosis (ARAS) groups, office and home BP decreased significantly after angioplasty (all P<0...
November 21, 2016: Hypertension
https://www.readbyqxmd.com/read/27858843/association-of-the-klk1-rs5516-g-allele-and-the-ace-d-allele-with-aortic-aneurysm-and-atherosclerotic-stenosis
#12
Yiming Zhang, Hongliang Huang, Yuliang Ma, Yifeng Sun, Guohua Wang, Liming Tang
OBJECTIVE: Atherosclerosis underlies aortic aneurysm (AA) and atherosclerotic stenosis (AS). Kallikrein-1 (KLK1) and angiotensin-converting enzyme (ACE) are 2 key molecules in kallikrein-kinin systems and renin-angiotensin systems, respectively, which are responsible for maintaining vascular balance and stability, playing important roles in atherosclerosis. We aimed to assess the involvement of single nucleotide polymorphism rs5516 in KLK1 as well as the insertion/deletion rs4646994 polymorphism in ACE in the development of AA and AS...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27843693/treatment-and-imaging-of-intracranial-atherosclerotic-stenosis-current-perspectives-and-future-directions
#13
REVIEW
Ido R van den Wijngaard, Ghislaine Holswilder, Marianne A A van Walderveen, Ale Algra, Marieke J H Wermer, Osama O Zaidat, Jelis Boiten
BACKGROUND AND PURPOSE: Intracranial atherosclerosis is a common cause of stroke worldwide. It results in ischemic stroke due to different mechanisms including artery-to-artery embolism, in situ thrombo-occlusion, occlusion of perforating arteries, and hemodynamic failure. In this review, we present an overview of current treatment and imaging modalities in intracranial atherosclerotic stenosis. METHODS: PubMed was searched for relevant articles in English that evaluated the treatment and imaging of intracranial atherosclerotic stenosis (ICAS)...
November 2016: Brain and Behavior
https://www.readbyqxmd.com/read/27836295/circulating-osteogenic-endothelial-progenitor-cell-counts-new-biomarker-for-the-severity-of-coronary-artery-disease
#14
Shi-Wei Yang, Rebecca R Hennessy, Sundeep Khosla, Ryan Lennon, Darrell Loeffler, Tao Sun, Zhi Liu, Kyoung-Ha Park, Fei-Long Wang, Lilach O Lerman, Amir Lerman
BACKGROUND: There is increasing evidence implying that the early and functionally highly active circulating endothelial progenitor cell (CEPC) phenotype (CD34-/CD133+/KDR+) with osteogenic potential (OCN+) might link between vascular atherosclerotic calcification and mechanisms of bone metabolism. We sought to evaluate the early OCN+ CEPC counts as an independent biomarker for the severity of coronary artery disease (CAD). METHODS: Peripheral blood samples were drawn from 593 patients undergoing clinically indicated coronary angiography...
October 27, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27827286/-hypertension-due-to-fibromuscular-dysplasia-look-for-additional-disease-sites
#15
M L Maas, J M Kroese, S J H Bredie, C T Postma, F E de Leeuw, L J Schultze Kool, N P Riksen
Fibromuscular dysplasia (FMD) is a non-inflammatory, non-atherosclerotic vasculopathy that can lead to arterial stenosis, occlusion, aneurysms, and dissection. FMD of the renal arteries can lead to renovascular hypertension. Percutaneous angioplasty of the renal arteries (PTRA) can lead to normalization of blood pressure in 45% of patients with renal artery stenosis caused by FMD, particularly in younger patients and patients with a short history of hypertension. A considerable number of the patients with renovascular FMD also have cervical FMD, which can lead to ischaemic or haemorrhagic stroke...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27824664/is-carotid-plaque-contrast-enhancement-on-mri-predictive-for-cerebral-or-cardiovascular-events-a-prospective-cohort-study
#16
Giacomo Davide Edoardo Papini, Giovanni Di Leo, Michele Bandirali, Biagio Cotticelli, Nicola Flor, Pietro Restivo, Giovanni Nano, Francesco Sardanelli
OBJECTIVE: The aim of this study was to correlate carotid plaque contrast enhancement (CPCE) to onset of cerebral/cardiovascular events (CCVE) in patients with atherosclerotic carotid disease. METHODS: The ethics committee approved this prospective study. Patients with carotid artery stenosis underwent magnetic resonance angiography before/after injection of 0.1 mmol/kg of gadobenate dimeglumine. Carotid plaque contrast enhancement was graded as follows: 0, no CPCE; 1, 1 single enhancement focus; 2, 2 or more foci...
November 7, 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27816341/stroke-prevention
#17
Clothilde Isabel, David Calvet, Jean-Louis Mas
Patients who have had a stroke are at high risk for recurrent stroke, myocardial infarction, and vascular death. Prevention of these events should be initiated promptly after stroke, because many recurrent events occur early, and should be tailored to the precise cause of stroke, which may require specific treatment. Lifestyle advice including abstinence from smoking, regular exercise, Mediterranean-style diet, and reduction of salt intake and alcohol consumption are recommended for all patients with stroke...
November 3, 2016: La Presse Médicale
https://www.readbyqxmd.com/read/27806835/determinants-of-carotid-atherosclerotic-plaque-burden-in-a-stroke-free-population
#18
Mariana Selwaness, Reinhard Hameeteman, Ronald Van 't Klooster, Quirijn Van den Bouwhuijsen, Albert Hofman, Oscar H Franco, Wiro J Niessen, Stefan Klein, Meike W Vernooij, Aad Van der Lugt, Jolanda J Wentzel
BACKGROUND AND AIMS: In a large stroke-free population, we sought to identify cardiovascular risk factors and carotid plaque components associated with carotid plaque burden, lumen volume and stenosis. METHODS: The carotid arteries of 1562 stroke-free participants from The Rotterdam Study were imaged on a 1.5-Tesla MRI scanner. Inner and outer wall of the carotid arteries were automatically segmented and lumen volume (mm(3)), wall volume (outer wall-inner wall) and plaque burden (wall volume/outer wall volume) (%) were quantified...
October 14, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27801305/spontaneous-coronary-artery-dissection-after-minimally-invasive-mitral-valve-repair
#19
Mirko Muretti, Mario Manca, Francesco Massi, Michele Portoghese
Spontaneous coronary artery dissection is a rare condition usually encountered in young women without risk factors for atherosclerotic disease but with tortuous coronary artery or contemporary presence of fibromuscular dysplasia. Sometimes spontaneous coronary dissection occurs in patients with atherosclerotic disease, although without significant epicardial coronary artery stenosis. We report a case of a patient who underwent minimally invasive mitral valve repair, whose initially uneventful postoperative course was complicated by spontaneous coronary artery dissection of the left main causing a life threatening condition...
October 31, 2016: Heart Surgery Forum
https://www.readbyqxmd.com/read/27797894/monocyte-chemoattractant-protein-1-levels-and-postangioplasty-restenosis-of-arteriovenous-fistulas
#20
Chih-Cheng Wu, Tsung-Yan Chen, Mu-Yang Hsieh, Lin Lin, Chung-Wei Yang, Shao-Yuan Chuang, Der-Cheng Tarng
BACKGROUND AND OBJECTIVES: Inflammation is relevant in restenosis of atherosclerotic vascular diseases, but its role in dialysis arteriovenous fistula remains unknown. In animal studies, upregulation of monocyte chemoattractant protein-1 has been shown in venous segments of arteriovenous fistula. We, therefore, aimed to investigate serial changes in circulating monocyte chemoattractant protein-1 after percutaneous transluminal angioplasty of dialysis arteriovenous fistulas and its relation to restenosis...
October 26, 2016: Clinical Journal of the American Society of Nephrology: CJASN
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