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https://www.readbyqxmd.com/read/29325952/endovascular-treatment-of-intracranial-aneurysms-concomitant-with-severe-adjacent-atherosclerotic-stenosis
#1
Bu-Lang Gao, Zhao-Shuo Li, Tian-Xiao Li, Jiang-Yu Xue, Guang Feng, Zi-Liang Wang, Wei-Xing Bai, Tong-Yuan Zhao, Xiao-Dong Liang
PURPOSE: To investigate the effect and safety of endovascular treatment of intracranial aneurysms concomitant with severe adjacent atherosclerotic stenosis. MATERIALS AND METHODS: Twenty-six patients with aneurysms and adjacent stenosis were prospectively enrolled. The characteristics of the aneurysm, parent artery, atherosclerotic stenosis and endovascular treatment methods were analyzed. RESULTS: All aneurysms were successfully embolized (100%), with stent-assisted coiling in forteen (53...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29325936/carotid-atherosclerotic-plaque-features-in-patients-with-acute-ischemic-stroke
#2
Runming Sun, Lixia Wang, Cuiling Guan, Wenyuan Cao, Bing Tian
OBJECTIVE: To investigate the carotid atherosclerotic plaque features in patients with acute ischemic stroke (AIS). METHODS: A total of 288 patients meeting the included criteria were enrolled and divided into ulcer plaque group (n = 139) and none ulcer plaque group (n = 149). Patients in ulcer plaque group were further subdivided into < and ≥ 50% stenosis group. Carotid plaque components characteristics including luminal stenosis, carotid plaque volume, hypoechoic plaque volume and hyperechoic plaque volume were analyzed by color Doppler ultrasound measurement...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29322167/use-of-high-risk-coronary-atherosclerotic-plaque-detection-for-risk-stratification-of-patients-with-stable-chest-pain-a-secondary-analysis-of-the-promise-randomized-clinical-trial
#3
Maros Ferencik, Thomas Mayrhofer, Daniel O Bittner, Hamed Emami, Stefan B Puchner, Michael T Lu, Nandini M Meyersohn, Alexander V Ivanov, Elizabeth C Adami, Manesh R Patel, Daniel B Mark, James E Udelson, Kerry L Lee, Pamela S Douglas, Udo Hoffmann
Importance: Coronary computed tomographic angiography (coronary CTA) can characterize coronary artery disease, including high-risk plaque. A noninvasive method of identifying high-risk plaque before major adverse cardiovascular events (MACE) could provide practice-changing optimizations in coronary artery disease care. Objective: To determine whether high-risk plaque detected by coronary CTA was associated with incident MACE independently of significant stenosis (SS) and cardiovascular risk factors...
January 10, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29321037/acute-aortoiliac-occlusive-disease-during-percutaneous-transluminal-angioplasty-in-the-setting-of-st-elevation-myocardial-infarction-a-case-report
#4
Anthony H Kashou, Nabil Braiteh, Ali Zgheib, Hisham E Kashou
BACKGROUND: Aortoiliac occlusive disease, which is also referred to as Leriche syndrome, is a chronic atherosclerotic occlusive disease that occurs at the level of the aortic bifurcation. It is often thought to present with a triad of clinical symptoms: (1) intermittent lower extremity vascular claudication, (2) impotence, and (3) weak/absent femoral pulses. CASE PRESENTATION: We report a case of a 47-year-old Caucasian woman who presented with an acute inferior ST-elevation myocardial infarction...
January 11, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29317141/serum-levels-of-osteopontin-predict-major-adverse-cardiovascular-events-in-patients-with-severe-carotid-artery-stenosis
#5
Federico Carbone, Fabio Rigamonti, Fabienne Burger, Aline Roth, Maria Bertolotto, Giovanni Spinella, Bianca Pane, Domenico Palombo, Aldo Pende, Aldo Bonaventura, Luca Liberale, Alessandra Vecchié, Franco Dallegri, François Mach, Fabrizio Montecucco
BACKGROUND: Inflammatory mediators in the blood stream and within plaques are key determinants in atherogenesis. Here, we investigated serum osteopontin (OPN) as a potential predictor of poor outcome in patients with severe carotid atherosclerosis. METHODS: Carotid plaques and serum were collected from patients asymptomatic (n=185) or symptomatic (n=40) for ischemic stroke. Plaques were stained for lipids, smooth muscle cells, neutrophils, M1 and M2 macrophage subsets and matrix metallopropteinase-9 (MMP-9)...
January 5, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29316212/renal-artery-stenting-for-atherosclerotic-renal-artery-stenosis-identified-in-patients-with-coronary-artery-disease-does-captopril-renal-scintigraphy-predict-outcomes
#6
Spyros Stratigis, Kostas Stylianou, Periklis P Kyriazis, Eleftheria-Kleio Dermitzaki, Dimitra Lygerou, Paraskevi Syngelaki, Stavros Stratakis, Sophia Koukouraki, Fragiskos Parthenakis, Dimitrios Tsetis, Eugene Daphnis
The authors evaluated the effectiveness of percutaneous renal revascularization (PRR) with stenting for the treatment of atherosclerotic renal artery stenosis (ARAS) in patients with coronary artery disease and the usefulness of captopril renal scintigraphy for predicting clinical outcomes after PRR. Sixty-four consecutive patients, referred for evaluation of suspected ARAS, after coronary angiography, underwent baseline captopril renal scintigraphy followed by renal angiography. Forty-four patients (68.7%) were diagnosed with a significant ARAS≥ 60% and were treated with PRR plus medical therapy...
January 6, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29312766/robotic-totally-endoscopic-coronary-artery-bypass-for-isolated-ostial-stenosis-of-the-left-coronary-artery
#7
Chia-Cheng Kuo, Chung-Hsi Hsing, Chun-I Chen, Chen-Hui Lee, Bor-Chih Cheng
Isolated ostial stenosis (IOS) is a rare disease that encroaches on aorto-coronary junction of uncertain etiology. All distal coronary vessels present normally. IOS occurs predominantly in premenopausal young women with few risk factors for atherosclerotic disease. Here, we report a 40-year-old woman who had experienced crescendo angina for 4 months. Surgical revascularization was achieved by robotic totally endoscopic coronary artery bypass (TECAB) with left internal thoracic artery (LITA) graft. She resumed her daily tasks without difficulties 1 week after the operation...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29301628/platelet-derived-mrp-14-induces-monocyte-activation-in-patients-with-symptomatic-peripheral-artery-disease
#8
Rebecca Dann, Tarik Hadi, Emilie Montenont, Ludovic Boytard, Dornaszadat Alebrahim, Jordyn Feinstein, Nicole Allen, Russell Simon, Krista Barone, Kunihiro Uryu, Yu Guo, Caron Rockman, Bhama Ramkhelawon, Jeffrey S Berger
BACKGROUND: Peripheral artery disease (PAD), a diffuse manifestation of atherothrombosis, is a major cardiovascular threat. Although platelets are primary mediators of atherothrombosis, their role in the pathogenesis of PAD remains unclear. OBJECTIVES: The authors sought to investigate the role of platelets in a cohort of symptomatic PAD. METHODS: The authors profiled platelet activity, mRNA, and effector roles in patients with symptomatic PAD and in healthy controls...
January 2, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29289980/magnetic-resonance-elastography-can-monitor-changes-in-medullary-stiffness-in-response-to-treatment-in-the-swine-ischemic-kidney
#9
Xin Zhang, Xiangyang Zhu, Christopher Martyn Ferguson, Kai Jiang, Tyson Burningham, Amir Lerman, Lilach Orly Lerman
OBJECTIVE: Low-energy shockwave (SW) therapy attenuates damage in the stenotic kidney (STK) caused by atherosclerotic renal artery stenosis (ARAS). We hypothesized that magnetic resonance elastography (MRE) would detect attenuation of fibrosis following SW in unilateral ARAS kidneys. MATERIALS AND METHODS: Domestic pigs were randomized to control, unilateral ARAS, and ARAS treated with 6 sessions of SW over 3 consecutive weeks (n = 7 each) starting after 3 weeks of ARAS or sham...
December 30, 2017: Magma
https://www.readbyqxmd.com/read/29286024/-subclavian-carotid-replacement-in-chronic-cerebrovascular-insufficiency-management
#10
A B Stepanenko, E R Charchyan, A P Gens, S V Fedulova, M N Seleznev, P N Shvedov
AIM: To present own experience of subclavian-carotid replacement for chronic cerebrovascular insufficiency management. MATERIAL AND METHODS: For 12 years 7 subclavian-carotid reconstructions were performed that was 1.2% of all carotid repairs during this period. Great saphenous vein was always used as a graft. Carotid endarterectomy from proximal internal carotid artery was additionally performed if it was necessary. Patients had severe advanced lesion of supra-aortic vessels including bilateral carotid lesion and significant stenosis of ipsilateral proximal common carotid artery...
2017: Khirurgiia
https://www.readbyqxmd.com/read/29284609/dkk3-dickkopf-3-alters-atherosclerotic-plaque-phenotype-involving-vascular-progenitor-and-fibroblast-differentiation-into-smooth-muscle-cells
#11
Eirini Karamariti, Chungang Zhai, Baoqi Yu, Qiao Lei, Zhihong Wang, Claire M F Potter, Mei Mei Wong, Russell M L Simpson, Zhongyi Zhang, Xiaocong Wang, Ivan Del Barco Barrantes, Christof Niehrs, Deling Kong, Qiang Zhao, Yun Zhang, Yanhua Hu, Cheng Zhang, Qingbo Xu
OBJECTIVES: DKK3 (dickkopf 3), a 36-kD secreted glycoprotein, has been shown to be involved in the differentiation of partially reprogrammed cells and embryonic stem cells to smooth muscle cells (SMCs), but little is known about its involvement in vascular disease. This study aims to assess the effects of DKK3 on atherosclerotic plaque composition. APPROACH AND RESULTS: In the present study, we used a murine model of atherosclerosis (ApoE-/-) in conjunction with DKK3-/- and performed tandem stenosis of the carotid artery to evaluate atherosclerotic plaque development...
December 28, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29284341/cerebral-perfusion-monitoring-in-adult-patients-following-cardiac-surgery-an-observational-study
#12
Tammy Slater, Julie Stanik-Hutt, Patricia Davidson
BACKGROUND: Strokes following adult cardiac surgery contribute to burdensome neurocognitive complications, which are often difficult to detect during the perioperative period. Fluctuations in regional cerebral perfusion and co-morbid conditions, such as hypertension, diabetes, prior stroke, symptomatic carotid stenosis, aortic atherosclerotic disease, and peripheral vascular disease are associated with perioperative strokes. Approaches to achieve optimal cerebral perfusion remain elusive and traditional strategies for perioperative monitoring are not always sufficiently sensitive to detect acute changes in cerebral perfusion...
December 28, 2017: Contemporary Nurse
https://www.readbyqxmd.com/read/29279888/prevalence-of-systemic-atherosclerosis-burdens-and-overlapping-stroke-etiologies-and-their-associations-with-long-term-vascular-prognosis-in-stroke-with-intracranial-atherosclerotic-disease
#13
Takao Hoshino, Leila Sissani, Julien Labreuche, Gregory Ducrocq, Philippa C Lavallée, Elena Meseguer, Céline Guidoux, Lucie Cabrejo, Cristina Hobeanu, Fernando Gongora-Rivera, Pierre-Jean Touboul, Philippe Gabriel Steg, Pierre Amarenco
Importance: Patients who have experienced stroke with intracranial atherosclerotic disease (ICAD) may also have concomitant atherosclerosis in different arterial beds and other possible causes for ischemic stroke. However, little is known about the frequency and prognostic effect of such overlapping diseases. Objectives: To describe the prevalence of systemic atherosclerotic burdens and overlapping stroke etiologies and their contributions to long-term prognoses among patients who have experienced stroke with ICAD...
December 26, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29279801/technical-factors-affecting-outcomes-following-endovascular-treatment-of-posterior-circulation-atherosclerotic-lesions
#14
Matthew D Alexander, Jeffrey M Rebhun, Steven W Hetts, Matthew R Amans, Fabio Settecase, Robert J Darflinger, Christopher F Dowd, Van V Halbach, Randall T Higashida, Daniel L Cooke
Background: Atherosclerotic disease of the vertebrobasilar system causes significant morbidity and mortality. All lesions require aggressive medical management, but the role of endovascular interventions remains unsettled. This study examines such endovascular interventions for vertebrobasilar atherosclerosis. Methods: Retrospective review was performed of prospectively maintained procedure logs at three hospitals with comprehensive neurointerventional services...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29275551/-expression-of-probnp-and-nt-probnp-in-sudden-death-of-coronary-heart-disease
#15
Q Zeng, R F Sun, Z Li, L Q Zhai, M Z Liu, X J Guo, C R Gao
OBJECTIVES: To study the expression change of pro-brain natriuretic peptide (proBNP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in sudden death of coronary atherosclerotic heart disease, and to explore its application in forensic diagnosis. METHODS: Myocardial and blood samples were collected from normal control group, sudden death of coronary atherosclerotic heart disease group and single coronary stenosis group (20 cases in each group)...
October 2017: Fa Yi Xue za Zhi
https://www.readbyqxmd.com/read/29258887/substantial-atherosclerotic-celiac-axis-stenosis-is-a-new-risk-factor-for-biliary-fistula-after-pancreaticoduodenectomy
#16
Yiran Zhou, Wei Wang, Yusheng Shi, Xiongxiong Lu, Qian Zhan, Hao Chen, Xiaxing Deng, Chenghong Peng, Baiyong Shen
BACKGROUND: Biliary fistula (BF) is a major surgical complication that can develop after pancreaticoduodenectomy (PD) whose risk factors remain unclear. Substantial atherosclerotic celiac axis stenosis (SACAS) has not been reported to be one of them. METHODS: Data from 507 patients undergoing PD between Jan 1, 2013 and Dec 31, 2015 were retrospectively collected. Clinical data from patients with SACAS were studied, and the independent risk factors for BF underwent multivariate logistic regression analysis, including SACAS...
December 16, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29233158/etiology-of-isolated-pontine-infarctions-a-study-based-on-high-resolution-mri-and-brain-small-vessel-disease-scores
#17
Cheng Xia, Hui-Sheng Chen, Shi-Wen Wu, Wei-Hai Xu
BACKGROUND: In this retrospective study, we investigated the main pathogenesis of the two types of isolated pontine infarction: paramedian pontine infarcts (PPIs) and small deep pontine infarcts (SDPIs). METHODS: Acute ischemic stroke patients, comprising 117 PPI patients and 40 SDPI patients, were enrolled. High-resolution magnetic resonance imaging (HR-MRI) and routine MRI sequences were performed for each patient, and clinical data were collected. The following brain small vessel disease (SVD) features of the MRI scans were each rated (0 or 1) separately: asymptomatic lacunar infarcts, white matter lesions (WMLs), deep and infratentorial cerebral microbleeds (CMBs), and enlarged perivascular spaces in the basal ganglia...
December 12, 2017: BMC Neurology
https://www.readbyqxmd.com/read/29231013/-diagnostic-value-of-postmortem-ct-angiography-in-coronary-atherosclerosis
#18
H Qian, Y Shao, Z D Li, D H Zou, Z Q Qin, L Wan, Y J Chen
OBJECTIVES: To explore the application value of postmortem computed tomography (CT) angiography on diagnosis of coronary atherosclerotic stenosis degree. METHODS: Based on the previous experimental results, the postmortem CT angiography device of human isolated heart was improved. Different coronary atherosclerotic stenosis degree of sudden death cases was selected. Before the cardiac anatomy, hearts were removed out completely and CT angiography was performed immediately...
April 2017: Fa Yi Xue za Zhi
https://www.readbyqxmd.com/read/29224743/clinical-study-of-intracranial-and-extracranial-atherosclerotic-stenosis-in-spontaneous-intracerebral-hemorrhage-patients
#19
Chun-Yang Zhang, Shi-Ren Huang, Si-Yang Wang, Lei Shen, Ben-Qiang Deng
BACKGROUND AND PURPOSE: Nowadays, researchers had begun to focus on the use of antiplatelet and statins in patients with spontaneous intracerebral hemorrhage (sICH), but atherosclerosis treatment remains uncertain in these patients. We aimed to investigate the incidence and characteristics of intracranial and extracranial atherosclerotic stenosis in these patients and analyze its related risk factors. METHODS: Intracranial and extracranial arteries of consecutive patients with sICH were studied retrospectively with computed tomography angiography of head and neck...
December 8, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29217492/the-potential-role-of-ideal-mri-for-identification-of-lipids-and-hemorrhage-in-carotid-artery-plaques
#20
Faisal Khosa, Rachel E Clough, Xiaoen Wang, Ananth J Madhuranthakam, Robert L Greenman
Hemorrhage and lipid deposits contribute to instability in atherosclerotic plaques. Unstable carotid artery plaques can lead to cerebral ischemic events. While MRI studies have shown the ability to identify plaque components, the identification of hemorrhage and lipids has proven to be problematic. The purpose of this study was to quantitatively evaluate the potential of the MRI fat/water separation method known as iterative decomposition of water and fat with echo asymmetry and least squares estimation (IDEAL) to complement and improve existing methods for the identification of hemorrhage and lipids in carotid artery plaques...
December 4, 2017: Magnetic Resonance Imaging
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