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Depression and occupational impairment

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https://www.readbyqxmd.com/read/29128195/-what-support-of-young-presenting-a-first-psychotic-episode-when-schooling-is-being-challenged
#1
M-N Vacheron, H Veyrat-Masson, E Wehbe
Psychiatric disorders (more specifically mood disorders and psychosis) represent the 1st cause of disability among young people. Unemployment rate between 75 to 95% for the person with schizophrenia. It is correlated to poor social integration and bad economic status, worse symptomatology loss of autonomy as well as global bad functioning. It is responsible of more than half of the overall cost of psychosis. The onset of most of psychiatric disorders occur between the age of 25 and 35 years old, a critical time in young adult life when they should build their professional as well as social future...
November 8, 2017: L'Encéphale
https://www.readbyqxmd.com/read/29121444/neurocognitive-functioning-clinical-course-and-functional-outcome-in-first-treatment-bipolar-i-disorder-patients-with-and-without-clinical-relapse-a-1-year-follow-up-study
#2
Christine Demmo, Trine V Lagerberg, Levi R Kvitland, Sofie R Aminoff, Tone Hellvin, Carmen Simonsen, Beathe Haatveit, Ole A Andreassen, Ingrid Melle, Torill Ueland
OBJECTIVES: Due to limited research on the association between recurrence of mood episodes and the longitudinal course of neurocognitive functioning in early phase bipolar I disorder (BD I), the impact of recurrence on neurocognition remains unclear. Further, a strong correlation between neurocognitive impairment and functional impairment has been demonstrated. The longitudinal relationship between neurocognitive impairment and functional outcome in relation to recurrence is, however, not established...
November 9, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/29109914/revisiting-the-tryptophan-serotonin-deficiency-and-the-inflammatory-hypotheses-of-major-depression-in-a-biopsychosocial-approach
#3
Andreas Baranyi, Omid Amouzadeh-Ghadikolai, Dirk von Lewinski, Robert J Breitenecker, Hans-Bernd Rothenhäusler, Christoph Robier, Maria Baranyi, Simon Theokas, Andreas Meinitzer
Background: The aim of this cross-sectional study was to identify important biopsychosocial correlates of major depression. Biological mechanisms, including the inflammatory and the tryptophan-serotonin deficiency hypotheses of major depression, were investigated alongside health-related quality of life, life satisfaction, and social support. Methods: The concentrations of plasma tryptophan, plasma kynurenine, plasma kynurenic acid, serum quinolinic acid, and the tryptophan breakdown to kynurenine were determined alongside health-related quality of life (Medical Outcome Study Form, SF-36), life satisfaction (Life Satisfaction Questionnaire, FLZ), and social support (Social Support Survey, SSS) in 71 depressive patients at the time of their in-patient admittance and 48 healthy controls...
2017: PeerJ
https://www.readbyqxmd.com/read/29098105/obsessive-compulsive-disorder-with-suicide-obsessions-in-a-first-responder-without-previous-diagnosis-of-ocd-or-history-of-suicide-attempts
#4
Vivekananda Rachamallu, Michael M Song, Haiying Liu, Charles L Giles, Terry McMahon
Obsessive-compulsive disorder (OCD) is a distressing and often debilitating disorder characterized by obsessions, compulsions, or both that are time-consuming and cause impairment in social, occupational, or other areas of functioning. There are many published studies reporting higher risk of suicidality in OCD patients, as well as studies describing increased risk of suicidality in OCD patients with other comorbid psychiatric conditions such as major depressive disorder (MDD) and posttraumatic stress disorder (PTSD)...
2017: Case Reports in Psychiatry
https://www.readbyqxmd.com/read/29077928/complexity-of-work-and-incident-cognitive-impairment-in-puerto-rican-older-adults
#5
Ross Andel, Ana Luisa Dávila-Roman, Catherine Grotz, Brent J Small, Kyriakos S Markides, Michael Crowe, Shevaun Neupert
Objective: We investigated complexity of work in main occupation in relation to incident cognitive impairment in older Puerto Ricans. Method: A population-based sample of 1,673 adults age 60+ for the Puerto Rican Elderly: Health Conditions (PREHCO) study was used. Cognition was measured at baseline and 4 years later using the Mini-Mental Cabán (MMC), with scoring 1.5 SD below the MMC score adjusted for age, education, gender, and reading ability comprising cognitive impairment...
October 25, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/29073885/cognitive-impairment-and-hypertension-in-older-adults-living-in-extreme-poverty-a-cross-sectional-study-in-peru
#6
Maria Lazo-Porras, Victor Ortiz-Soriano, Miguel Moscoso-Porras, Fernando M Runzer-Colmenares, German Málaga, J Jaime Miranda
BACKGROUND: Previous studies have shown that hypertension is a risk factor for cognitive impairment, but whether this association is also present in extremely poor populations in Low Middle Income Countries settings remains to be studied. Understanding other drivers of cognitive impairment in this unique population also merits attention. METHODS: We performed a secondary analysis using data from the "Encuesta de Salud y Bienestar del Adulto Mayor", a regional survey conducted in an extremely poor population of people older than 65 years old from 12 Peruvian cities in 2012...
October 26, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29059120/change-in-depression-confidence-and-physical-function-among-older-adults-with-mild-cognitive-impairment
#7
Jennifer L Ellis, Peter Altenburger, Yvonne Lu
BACKGROUND AND PURPOSE: Nearly a quarter of those in the United States older than 71 years experience mild cognitive impairment. Persons with mild cognitive impairment battle depression and progressive disengagement from daily activities, which contribute to participation restriction and activity limitation. Daily engagement in meaningful activity (DEMA) is a tailored intervention designed to benefit persons with mild cognitive impairment and their caregivers through preserved engagement and supported adjustment to cognitive changes...
October 20, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/29057596/the-anaclitic-introjective-depression-assessment-development-and-preliminary-validity-of-an-observer-rated-measure
#8
Felicitas Rost, Patrick Luyten, Peter Fonagy
BACKGROUND: The two-configurations model developed by Blatt and colleagues offers a comprehensive conceptual and empirical framework for understanding depression. This model suggests that depressed patients struggle, at different developmental levels, with issues related to dependency (anaclitic issues) or self-definition (introjective issues), or a combination of both. AIMS: This paper reports three studies on the development and preliminary validation of the Anaclitic-Introjective Depression Assessment, an observer-rated assessment tool of impairments in relatedness and self-definition in clinical depression based on the item pool of the Shedler-Westen Assessment Procedure...
October 23, 2017: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/29033569/associations-among-depression-severity-painful-physical-symptoms-and-social-and-occupational-functioning-impairment-in-patients-with-major-depressive-disorder-a-3-month-prospective-observational-study
#9
Eiji Harada, Yoichi Satoi, Atsushi Kuga, Hirofumi Tokuoka, Toshiaki Kikuchi, Koichiro Watanabe, Levent Alev, Masaru Mimura
PURPOSE: To investigate associations among depression severity, painful physical symptoms (PPS), and social and occupational functioning impairment in patients with major depressive disorder (MDD) who had achieved complete remission (CR) or partial remission (PR) after acute treatment. PATIENTS AND METHODS: This was a 12-week, multicenter, prospective, observational study. Patients with MDD treated with an antidepressant medication for the previous 12 weeks (±3 weeks) who had achieved CR (defined as a 17-item Hamilton Rating Scale for Depression [HAM-D17] score ≤7) or PR (HAM-D17 score ≥8 and ≤18) were enrolled...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28981811/prospective-relationships-between-motivation-and-functioning-in-recovery-after-a-first-episode-of-schizophrenia
#10
Daniel Fulford, Danijela Piskulic, Jean Addington, John M Kane, Nina R Schooler, Kim T Mueser
Diminished motivation is associated with robust impairment in psychosocial functioning in schizophrenia (SZ). Little is known about the reciprocal relationships between motivation and functioning, particularly following a first episode of psychosis. We tested bidirectional associations between motivation and social and occupational functioning in the year following a first episode of SZ spectrum disorder among patients in the Recovery After an Initial Schizophrenia Episode-Early Treatment Program (RAISE-ETP) study...
August 18, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28972891/executive-control-erp-and-pro-inflammatory-activity-in-emotionally-exhausted-middle-aged-employees-comparison-between-subclinical-burnout-and-mild-to-moderate-depression
#11
Patrick D Gajewski, Sylvia Boden, Gabriele Freude, Guy G Potter, Maren Claus, Peter Bröde, Carsten Watzl, Stephan Getzmann, Michael Falkenstein
Burnout is a syndrome occurring mainly in individuals with long-term stressful work. The main complaints are emotional exhaustion and reduced performance. Burnout also largely overlaps with depression. Both are characterized by increased incidence of infections due to dysregulation of the immune system, overexpression of pro-inflammatory cytokines and cognitive deficits, particularly related to executive functions. To distinguish between burnout and depression already at the pre-clinical stage, the present double-blinded study compared immunological and cognitive parameters in seventy-six employees from emotionally demanding occupations who were post-hoc subdivided into two groups scoring low (EE-) and high (EE+) in emotional exhaustion and low (DE-) and high (DE+) in depression...
December 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28961463/impact-of-personality-pathology-on-psychosocial-functioning
#12
REVIEW
Andrew E Skodol
Personality disorders impair social, occupational, leisure, and global functioning more than a significant disorder such as major depressive disorder. Impairment is found in clinical and community populations. Impairment is independent of co-occurring other mental disorders. Impairment is more stable over time than are the diagnoses themselves. Personality traits are also impairing and may be more predictive of outcomes over time, but a hybrid of personality disorder features and normal range personality traits may be the most predictive model...
September 14, 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28959195/prenatal-exposure-to-paint-thinner-alters-postnatal-development-and-behavior-in-mice
#13
Hanaa Malloul, Ferdaousse M Mahdani, Mohammed Bennis, Saadia Ba-M'hamed
Occupational exposure and sniffing of volatile organic solvents continue to be a worldwide health problem, raising the risk for teratogenic sequelae of maternal inhalant abuse. Real life exposures usually involve simultaneous exposures to multiple solvents, and almost all the abused solvents contain a mixture of two or more different volatile compounds. However, several studies examined the teratogenicity due to industrial exposure to a single volatile solvent but investigating the teratogenic potential of complex chemical mixture such as thinner remains unexplored...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28954811/preclinical-characterization-of-r-3-3s-4s-3-fluoro-4-4-hydroxyphenyl-piperidin-1-yl-1-4-methylbenzyl-pyrrolidin-2-one-bms-986169-a-novel-intravenous-glutamate-n-methyl-d-aspartate-2b-glun2b-receptor-negative-allosteric-modulator-with-potential-in-major-depressive
#14
Linda J Bristow, Jyoti Gulia, Michael R Weed, Bettadapura N Srikumar, Yu-Wen Li, John D Graef, Pattipati S Naidu, Charulatha Sanmathi, Jayant Aher, Tanmaya Bastia, Mahesh Paschapur, Narasimharaju Kalidindi, Kuchibholta Vijaya Kumar, Thaddeus Molski, Rick Pieschl, Alda Fernandes, Jeffrey M Brown, Digavalli V Sivarao, Kimberly Newberry, Mark Bookbinder, Joseph Polino, Deborah Keavy, Amy Newton, Eric Shields, Jean Simmermacher, James Kempson, Jianqing Li, Huiping Zhang, Arvind Mathur, Raja Reddy Kallem, Meenakshee Sinha, Manjunath Ramarao, Reeba K Vikramadithyan, Srinivasan Thangathirupathy, Jayakumar Warrier, Joanne J Bronson, Richard E Olson, John E Macor, Charlie F Albright, Dalton King, Lorin A Thompson, Lawrence R Marcin, Michael Sinz
(R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), and the phosphate prodrug (BMS-986163), were identified from a drug discovery effort focused on the development of novel, intravenous, glutamate N-methyl-D-aspartate 2B receptor (GluN2B) negative allosteric modulators for treatment resistant depression (TRD). BMS-986169 showed high binding affinity for the GluN2B subunit allosteric modulatory site (Ki = 4.03-6.3 nM) and selectively inhibited GluN2B receptor function in Xenopus oocytes expressing human N-methyl-D-aspartate receptor subtypes (IC50 = 24...
September 27, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28924412/adding-access-to-a-video-magnifier-to-standard-vision-rehabilitation-initial-results-on-reading-performance-and-well-being-from-a-prospective-randomized-study
#15
Mary Lou Jackson, Kimberly A Schoessow, Alexandra Selivanova, Jennifer Wallis
PURPOSE: Both optical and electronic magnification are available to patients with low vision. Electronic video magnifiers are more expensive than optical magnifiers, but they offer additional benefits, including variable magnification and contrast. This study aimed to evaluate the effect of access to a video magnifier (VM) added to standard comprehensive vision rehabilitation (VR). METHODS: In this prospective study, 37 subjects with central field loss were randomized to receive standard VR (VR group, 18 subjects) or standard VR plus VM (VM group, 19 subjects)...
2017: Digital Journal of Ophthalmology: DJO
https://www.readbyqxmd.com/read/28922588/persistent-negative-symptoms-in-first-episode-psychosis-early-cognitive-and-social-functioning-correlates-and-differences-between-early-and-adult-onset
#16
Olga Puig, Immaculada Baeza, Elena de la Serna, Bibiana Cabrera, Gisela Mezquida, Miquel Bioque, Antonio Lobo, Ana González-Pinto, Mara Parellada, Iluminada Corripio, Eduard Vieta, Julio Bobes, Judith Usall, Fernando Contreras, Manuel J Cuesta, Miquel Bernardo, Josefina Castro-Fornieles, The PEPs Group
OBJECTIVE: To characterize the early cognitive and social functioning characteristics of a sample of first-episode psychosis patients with and without persistent negative symptoms (PNS) and to examine the prevalence and cognitive and functional correlates of PNS in patients with early-onset versus adult-onset first-episode psychosis. METHODS: Participants were 235 patients with first-episode psychosis (51 early-onset, 184 adult-onset) and 240 healthy controls from a multicenter longitudinal study (recruited between 2009 and 2011)...
September 12, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28915338/neurocognitive-psychosocial-and-quality-of-life-outcomes-in-adult-survivors-of-childhood-non-hodgkin-lymphoma
#17
Matthew J Ehrhardt, Daniel A Mulrooney, Chenghong Li, Malek J Baassiri, Kari Bjornard, John T Sandlund, Tara M Brinkman, I-Chan Huang, Deo Kumar Srivastava, Kirsten K Ness, Leslie L Robison, Melissa M Hudson, Kevin R Krull
BACKGROUND: Children with non-Hodgkin lymphoma (NHL) undergo treatment with central nervous system-directed therapy, the potentially neurotoxic effects of which have not been reported in NHL survivors. METHODS: NHL survivors (n = 187) participating in the St. Jude Lifetime Cohort who were 10 or more years from their diagnosis and were 18 years old or older underwent neurocognitive, emotional distress (Brief Symptom Inventory 18), and health-related quality of life (HRQOL) assessments (36-Item Short Form Health Survey)...
September 15, 2017: Cancer
https://www.readbyqxmd.com/read/28901547/cognitive-functioning-following-one-year-natalizumab-treatment-a-non-randomized-clinical-trial
#18
I Rorsman, C Petersen, P C Nilsson
OBJECTIVES: Cognitive impairment is common in multiple sclerosis (MS) and can have serious impact on social and occupational functioning. Natalizumab reduces relapse rates, magnetic resonance imaging (MRI) lesions, and progression of disability. Previous studies on cognitive functioning have not based inclusion on cognitive performance criteria. The aim of the present study was to determine any potential natalizumab-related cognitive effects on MS patients performing below normal limits on neuropsychological testing...
September 13, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28844451/risk-factors-for-new-onset-depression-after-first-time-traumatic-brain-injury
#19
Durga Roy, Vassilis Koliatsos, Sandeep Vaishnavi, Dingfen Han, Vani Rao
BACKGROUND: Major depression after traumatic brain injury (TBI) has devastating consequences as it increases the risk of suicide, impairs overall quality of life, and affects interpersonal, occupational, and social functioning. Although the literature has reported factors associated with depression after TBI, very few studies have examined the prevalence and correlates focused on the development of new-onset depression (NOD) after first-time TBI. Our study aimed to identify TBI- and non-TBI-related factors associated with the development of NOD in the first year after TBI...
July 20, 2017: Psychosomatics
https://www.readbyqxmd.com/read/28837932/quality-of-life-in-individuals-with-attenuated-psychotic-symptoms-possible-role-of-anxiety-depressive-symptoms-and-socio-cognitive-impairments
#20
Tsutomu Takahashi, Yuko Higuchi, Yuko Komori, Shimako Nishiyama, Mihoko Nakamura, Daiki Sasabayashi, Yumiko Nishikawa, Tomiki Sumiyoshi, Michio Suzuki
Individuals with Clinical High-Risk state for Psychosis (CHR-P) are reported to exhibit impaired quality of life (QOL) similar to that observed in schizophrenia, but its determinants remain unclear. We investigated the QOL of 33 subjects with CHR-P, 45 patients with schizophrenia, and 63 healthy subjects using the Quality of Life Scale (QLS). The CHR-P and schizophrenia groups were administered the Brief Assessment of Cognition in Schizophrenia (BACS), the Schizophrenia Cognition Rating Scale (SCoRS), and the Social and Occupational Functioning Assessment Scale (SOFAS) for socio-cognitive functions; and the Positive and Negative Syndrome Scale (PANSS) and the State-Trait Anxiety Inventory for clinical symptoms...
August 16, 2017: Psychiatry Research
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