keyword
MENU ▼
Read by QxMD icon Read
search

TNFR2

keyword
https://www.readbyqxmd.com/read/29768622/single-nucleotide-polymorphisms-of-cytokine-related-genes-and-association-with-clinical-outcome-in-a-chagas-disease-case-control-study-from-brazil
#1
Lucia Elena Alvarado-Arnez, Angelica Martins Batista, Silvia Marinho Alves, Gloria Melo, Virgínia Maria Barros de Lorena, Cynthia C Cardoso, Isabela Resende Pereira, Cristina Carrazzone, Antonio G Pacheco, Wilson Oliveira, Milton Ozório Moraes, Joseli Lannes-Vieira
BACKGROUND: The severity of chronic chagasic cardiomyopathy (CCC), the most frequent clinical outcome of Chagas disease (CD), has been associated with cytokine-enriched heart tissue inflammation, and high serum levels of transforming growth factor (TGFβ), interferon-gamma (IFNγ), and tumour necrosis factor (TNF). Conversely, increased interleukin (IL)-10 serum concentrations have been associated with asymptomatic CD. Cytokines and cytokine-related gene polymorphisms may control cytokine expression and have been proposed to contribute to CCC outcomes...
May 14, 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29760711/selective-modulation-of-tnf-tnfrs-signaling-insights-for-multiple-sclerosis-treatment
#2
REVIEW
Valentina Pegoretti, Wia Baron, Jon D Laman, Ulrich L M Eisel
Autoimmunity develops when self-tolerance mechanisms are failing to protect healthy tissue. A sustained reaction to self is generated, which includes the generation of effector cells and molecules that destroy tissues. A way to restore this intrinsic tolerance is through immune modulation that aims at refurbishing this immunologically naïve or unresponsive state, thereby decreasing the aberrant immune reaction taking place. One major cytokine has been shown to play a pivotal role in several autoimmune diseases such as rheumatoid arthritis (RA) and multiple sclerosis (MS): tumor necrosis factor alpha (TNFα) modulates the induction and maintenance of an inflammatory process and it comes in two variants, soluble TNF (solTNF) and transmembrane bound TNF (tmTNF)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29749399/autocrine-tnf-signaling-favors-malignant-cells-in-myelofibrosis-in-a-tnfr2-dependent-fashion
#3
William L Heaton, Anna V Senina, Anthony D Pomicter, Mohamed E Salama, Phillip M Clair, Dongqing Yan, Russell N Bell, Jeremy M Gililland, Josef T Prchal, Thomas O'Hare, Michael W Deininger
Tumor necrosis factor alpha (TNF) is increased in myelofibrosis (MF) and promotes survival of malignant over normal cells. The mechanisms altering TNF responsiveness in MF cells are unknown. We show that the proportion of marrow (BM) cells expressing TNF is increased in MF compared to controls, with the largest differential in primitive cells. Blockade of TNF receptor 2 (TNFR2), but not TNFR1, selectively inhibited colony formation by MF CD34+ and mouse JAK2V617F progenitor cells. Microarray of mouse MPN revealed reduced expression of X-linked inhibitor of apoptosis (Xiap) and mitogen-activated protein kinase 8 (Mapk8) in JAK2V617F relative to JAK2WT cells, which were normalized by TNFR2 but not TNFR1 blockade...
April 18, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29748156/tl1a-mediates-fibroblast-like-synoviocytes-migration-and-indian-hedgehog-signaling-pathway-via-tnfr2-in-patients-with-rheumatoid-arthritis
#4
Mahmoud Al-Azab, Jing Wei, Xunli Ouyang, Abdalkhalig Elkhider, Williams Walana, Xiaotong Sun, Yawei Tang, Bing Wang, Xia Li
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joints inflammation. One of the aggressive characteristics of RA fibroblast-like synoviocytes (FLS) is the tendency for migration in the local environment, which plays a central role in the RA pathogenesis. Tumor Necrosis Factor (TNF)-like cytokine 1A (TL1A) is a member of TNF superfamily, which has a role in autoimmunity and influences the RA-FLS behavior through TNF receptor 2 (TNFR2). We investigated the effect of TNF-like cytokine 1A (TL1A) on RA-FLS migration using patients' samples...
March 1, 2018: European Cytokine Network
https://www.readbyqxmd.com/read/29740434/lack-of-evidence-for-a-direct-interaction-of-progranulin-and-tumor-necrosis-factor-receptor-1-and-tumor-necrosis-factor-receptor-2-from-cellular-binding-studies
#5
Isabell Lang, Simone Füllsack, Harald Wajant
Progranulin (PGRN) is a secreted anti-inflammatory protein which can be processed by neutrophil proteases to various granulins. It has been reported that at least a significant portion of the anti-inflammatory effects of PGRN is due to direct high affinity binding to tumor necrosis factor receptor-1 (TNFR1) and TNFR2 and inhibition of tumor necrosis factor (TNF)-induced TNFR1/2 signaling. Two studies failed to reproduce the interaction of TNFR1 and TNFR2 with PGRN, but follow up reports speculated that this was due to varying experimental circumstances and/or the use of PGRN from different sources...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29738072/combined-inflammation-and-metabolism-biomarker-indices-of-robust-and-impaired-physical-function-in-older-adults
#6
Xintong Zuo, Alison Luciano, Carl F Pieper, James R Bain, Virginia B Kraus, William E Kraus, Miriam C Morey, Harvey J Cohen
OBJECTIVES: To determine whether combinations of inflammatory markers are related to physical function. DESIGN AND SUBJECTS: secondary analysis of baseline of three observational studies of community-dwelling older adults MEASUREMENTS: The baseline data from 3 cohorts of older adults with different health and disease status were employed. Twenty markers of inflammation and metabolism were individually assessed for correlation with usual gait speed and were separated into robust and impairment quartiles...
May 8, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29725328/role-of-tnf-tnf-receptor-2-signal-in-regulatory-t-cells-and-its-therapeutic-implications
#7
REVIEW
Sujuan Yang, Julie Wang, David Douglass Brand, Song Guo Zheng
Tumor necrosis factor α (TNFα) is a pleiotropic cytokine which signals through TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2). Emerging evidence has demonstrated that TNFR1 is ubiquitously expressed on almost all cells, while TNFR2 exhibits a limited expression, predominantly on regulatory T cells (Tregs). In addition, the signaling pathway by sTNF via TNFR1 mainly triggers pro-inflammatory pathways, and mTNF binding to TNFR2 usually initiates immune modulation and tissue regeneration. TNFα plays a critical role in upregulation or downregulation of Treg activity...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29719531/characterization-of-chicken-tumor-necrosis-factor-%C3%AE-a-long-missed-cytokine-in-birds
#8
Franziska Rohde, Benjamin Schusser, Tomáš Hron, Helena Farkašová, Jiří Plachý, Sonja Härtle, Jiří Hejnar, Daniel Elleder, Bernd Kaspers
Tumor necrosis factor-α (TNF-α) is a pleiotropic cytokine playing critical roles in host defense and acute and chronic inflammation. It has been described in fish, amphibians, and mammals but was considered to be absent in the avian genomes. Here, we report on the identification and functional characterization of the avian ortholog. The chicken TNF-α (chTNF-α) is encoded by a highly GC-rich gene, whose product shares with its mammalian counterpart 45% homology in the extracellular part displaying the characteristic TNF homology domain...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29690885/blockade-of-sustained-tumor-necrosis-factor-in-a-transgenic-model-of-progressive-autoimmune-encephalomyelitis-limits-oligodendrocyte-apoptosis-and-promotes-oligodendrocyte-maturation
#9
Alice Valentin-Torres, Carine Savarin, Joslyn Barnett, Cornelia C Bergmann
BACKGROUND: Tumor necrosis factor (TNF) is associated with several neurodegenerative disorders including multiple sclerosis (MS). Although TNF-targeted therapies have been largely unsuccessful in MS, recent preclinical data suggests selective soluble TNF inhibition can promote remyelination. This has renewed interest in regulation of TNF signaling in demyelinating disease, especially given the limited treatment options for progressive MS. Using a mouse model of progressive MS, this study evaluates the effects of sustained TNF on oligodendrocyte (OLG) apoptosis and OLG precursor cell (OPC) differentiation...
April 24, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29686027/10-year-associations-between-tumor-necrosis-factor-receptors-1-and-2-and-cardiovascular-events-in-patients-with-stable-coronary-heart-disease-a-claricor-effect-of-clarithromycin-on-mortality-and-morbidity-in-patients-with-ischemic-heart-disease-trial-substudy
#10
Axel C Carlsson, Toralph Ruge, Erik Kjøller, Jørgen Hilden, Hans Jørn Kolmos, Ahmad Sajadieh, Jens Kastrup, Gorm Boje Jensen, Anders Larsson, Christoph Nowak, Janus Christian Jakobsen, Per Winkel, Christian Gluud, Johan Ärnlöv
BACKGROUND: We aimed to assess the associations and predictive powers between the soluble receptors for tumor necrosis factor (TNF)-α (TNFR1 and TNFR2) and cardiovascular outcomes in patients with stable coronary heart disease. METHODS AND RESULTS: CLARICOR (Effect of Clarithromycin on Mortality and Morbidity in Patients With Ischemic Heart Disease) is a randomized clinical trial comparing clarithromycin with placebo in patients with stable coronary heart disease...
April 23, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29685497/plasma-biomarkers-are-associated-with-renal-outcomes-in-individuals-with-apol1-risk-variants
#11
Girish N Nadkarni, Kinsuk Chauhan, Divya A Verghese, Chirag R Parikh, Ron Do, Carol R Horowitz, Erwin P Bottinger, Steven G Coca
G1/G2 variants in the Apolipoprotein L1 (APOL1) gene are associated with end-stage renal disease (ESRD) in people with African ancestry. Plasma biomarkers may have utility for risk stratification in APOL1 high-risk individuals of African ancestry. To evaluate this, we measured tumor necrosis factor receptor 1/2 (TNFR1/2) and kidney injury molecule-1 (KIM1) in baseline plasma specimens from individuals of African ancestry with high-risk APOL1 genotype. Biomarker association with a composite renal outcome of ESRD or 40% sustained decline in estimated glomerular filtration rate (eGFR) was then determined and then assessed as improvement in area under curve...
April 20, 2018: Kidney International
https://www.readbyqxmd.com/read/29623079/the-significance-of-tumor-necrosis-factor-receptor-type-ii-in-cd8-regulatory-t-cells-and-cd8-effector-t-cells
#12
REVIEW
Lin-Lin Ye, Xiao-Shan Wei, Min Zhang, Yi-Ran Niu, Qiong Zhou
Tumor necrosis factor (TNF) is a pleiotropic cytokine that has both pro-inflammatory and anti-inflammatory functions. The biological functions of TNF are mediated by two receptors, TNF receptor type I (TNFR1) and TNF receptor type II (TNFR2). TNFR1 is expressed universally on almost all cell types and has been extensively studied, whereas TNFR2 is mainly restricted to immune cells and some tumor cells and its role is far from clarified. Studies have shown that TNFR2 mediates the stimulatory activity of TNF on CD4+ Foxp3+ regulatory T cells (Tregs) and CD8+ Foxp3+ Tregs, and is involved in the phenotypic stability, proliferation, activation, and suppressive activity of Tregs...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29619032/an-autocrine-tnf%C3%AE-tumor-necrosis-factor-receptor-2-loop-promotes-epigenetic-effects-inducing-human-treg-stability-in-vitro
#13
Paulo C M Urbano, Hans J P M Koenen, Irma Joosten, Xuehui He
A crucial issue for Treg-based immunotherapy is to maintain a bona fide Treg phenotype as well as suppressive function during and after ex vivo expansion. Several strategies have been applied to harness Treg lineage stability. For instance, CD28 superagonist stimulation in vitro , in the absence of CD3 ligation, is more efficient in promoting Treg proliferation, and prevention of pro-inflammatory cytokine expression, such as IL-17, as compared to CD3/CD28-stimulated Treg. Addition of the mTOR inhibitor rapamycin to Treg cultures enhances FOXP3 expression and Treg stability, but does impair proliferative capacity...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29618659/mesenchymal-tnfr2-promotes-the-development-of-polyarthritis-and-comorbid-heart-valve-stenosis
#14
Maria Sakkou, Panagiotis Chouvardas, Lydia Ntari, Alejandro Prados, Kristin Moreth, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, Maria C Denis, Niki Karagianni, George Kollias
Mesenchymal TNF signaling is etiopathogenic for inflammatory diseases such as rheumatoid arthritis and spondyloarthritis (SpA). The role of Tnfr1 in arthritis has been documented; however, Tnfr2 functions are unknown. Here, we investigate the mesenchymal-specific role of Tnfr2 in the TnfΔARE mouse model of SpA in arthritis and heart valve stenosis comorbidity by cell-specific, Col6a1-cre-driven gene targeting. We find that TNF/Tnfr2 signaling in resident synovial fibroblasts (SFs) and valvular interstitial cells (VICs) is detrimental for both pathologies, pointing to common cellular mechanisms...
April 5, 2018: JCI Insight
https://www.readbyqxmd.com/read/29593717/tumor-necrosis-factor-%C3%AE-and-regulatory-t-cells-in-oncoimmunology
#15
REVIEW
Benoît L Salomon, Mathieu Leclerc, Jimena Tosello, Emilie Ronin, Eliane Piaggio, José L Cohen
Tumor necrosis factor α (TNF) is a potent pro-inflammatory cytokine that has deleterious effect in some autoimmune diseases, which led to the use of anti-TNF drugs in some of these diseases. However, some rare patients treated with these drugs paradoxically develop an aggravation of their disease or new onset autoimmunity, revealing an immunosuppressive facet of TNF. A possible mechanism of this observation is the direct and positive effect of TNF on regulatory T cells (Tregs) through its binding to the TNF receptor type 2 (TNFR2)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29576600/tumor-necrosis-factor-alpha-improves-glucose-homeostasis-in-diabetic-mice-independent-with-tumor-necrosis-factor-receptor-1-and-tumor-necrosis-factor-receptor-2
#16
Shanshan Wu, Kai Dong, Jiajia Wang, Yaxin Bi
Type 2 diabetes is a serious threat to human health all over the world. It is particularly important to look for the pathogenesis of type 2 diabetes. Researchers have found that obesity was associated with a broad chronic inflammatory response and type 2 diabetes. And tumor necrosis factor alpha (TNF-α) is one of the most important cytokines related with obesity. To explore the functional role of TNF-α in the regulation of glucose homeostasis, TNF-α receptor 1 and TNF-α receptor 2 double knockout (TNFR1/R2 DKO) mouse model were used in our study...
March 23, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29575795/synthesis-and-effect-of-a-new-terbium-gibberellic-complex-on-the-histopathological-alteration-induced-by-gibberellic-acid-on-liver-and-kidney-of-mice-mus-musculus
#17
Amin A Seleem, Belal H M Hussein
The objective of this study was to synthesize Gibberellic lanthanide complex and evaluate its biological activity to reduce the Gibberellic acid toxicity on liver and kidney. The new bis (Gibberellic)-nitro-terbium(III) complex was characterized by different analytical methods: elemental analyses, Uv-vis, molar ratio, fluorescence, FT-IR, and TGA-DTA measurements. Thirty newborns were classified into three groups control, Gibberellic acid, and Terbium gibberellic acid complex. Livers and kidneys of studied groups proceed for general histology and immunohistochemical staining of Cyr61, cytochrome C, and TNFR2...
March 25, 2018: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29575262/structural-basis-for-tumor-necrosis-factor-blockade-with-the-therapeutic-antibody-golimumab
#18
Masatsugu Ono, Shoichiro Horita, Yumi Sato, Yayoi Nomura, So Iwata, Norimichi Nomura
Tumor necrosis factor α (TNFα) is a proinflammatory cytokine, and elevated levels of TNFα in serum are associated with various autoimmune diseases, including rheumatoid arthritis (RA), ankylosing spondylitis (AS), Crohn's disease (CD), psoriasis and systemic lupus erythaematosus. TNFα performs its pleiotropic functions by binding to two structurally distinct transmembrane receptors, TNF receptor (TNFR) 1 and TNFR2. Antibody-based therapeutic strategies that block excessive TNFα signaling have been shown to be effective in suppressing such harmful inflammatory conditions...
March 25, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29559979/association-of-tnfrsf1b-promoter-polymorphisms-with-human-disease-further-studies-examining-t-regulatory-cells-are-required
#19
Hongchuan Li, Stephen K Anderson
The TNFR2 receptor is expressed by highly active regulatory T cells, and thus constitutes an important therapeutic target for the treatment of autoimmune disease and cancer. Disease susceptibility as well as the potential response to therapies directed at TNFR2 could be significantly impacted by genetic variation in the promoter of the TNFRSF1B gene that codes for the TNFR2 protein. To date, only a few studies have examined the association of TNFRSF1B promoter variation with disease, and the potential impact on T-regulatory cell (Treg) number and function has not been examined...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29547707/levels-of-soluble-tumor-necrosis-factor-receptor-1-and-2-gender-and-risk-of-myocardial-infarction-in-northern-sweden
#20
Axel C Carlsson, Jan-Håkan Jansson, Stefan Söderberg, Toralph Ruge, Anders Larsson, Johan Ärnlöv
BACKGROUND AND AIMS: Soluble receptors for tumor necrosis factor alpha (sTNFR1 and sTNFR2) have been associated with cardiovascular diseases, and some evidence points towards a difference in associated risk between men and women. We aimed to study the association between sTNFR1 and sTNFR2 and incident myocardial infarctions (MI) and to explore the influence of established cardiovascular risk factors in men and women. METHODS: We conducted a nested case control study in three large Swedish cohorts, including 533 myocardial infarction cases, and 1003 age-, sex- and cohort-matched controls...
May 2018: Atherosclerosis
keyword
keyword
53446
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"