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T Y Wang, Z J Li, G An, S H Deng, W W Sui, L G Qiu
No abstract text is available yet for this article.
March 14, 2018: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
Yuanqin Yin, Jingjing Cai, Fandong Meng, Chengguang Sui, Youhong Jiang
OBJECTIVE: The study aimed to investigate the molecular mechanism of miR-144 and CEP55 as well as the influence of their interaction on the cell proliferation, migration, invasion, cell cycle and cell apoptosis in breast cancer. METHODS: In this study, The Cancer Genome Atlas (TCGA, ) database was used for microarray analysis. The expressions of miR-144 and CEP55 in 40 adjacent tissues and 36 tumor tissues were examined by western blot, qRT-PCR and immunohistochemistry...
March 21, 2018: Cancer Biology & Therapy
Ting Xin, Xintao Gao, Hongjun Yang, Pingjun Li, Qianqian Liang, Shaohua Hou, Xiukun Sui, Xiaoyu Guo, Weifeng Yuan, Hongfei Zhu, Jiabo Ding, Hong Jia
Bovine tuberculosis (bTB) is primarily caused by infection with Mycobacterium bovis , which belongs to the Mycobacterium tuberculosis complex. The airborne route is considered the most common for transmission of M. bovis , and more than 15% of cattle with bTB shed the Mycobacterium , which can be detect by nested PCR to amplify mycobacterial mpb 70 from a nasal swab from a cow. To screen for cytokines fostering early and accurate detection of bTB, peripheral blood mononuclear cells were isolated from naturally M...
2018: Frontiers in Veterinary Science
Shu-Mei Chen, Yi-Jen Peng, Chih-Chien Wang, Sui-Lung Su, Donald M Salter, Herng-Sheng Lee
Glucocorticoid therapy, especially at higher doses, is associated with significant adverse side effects including osteoporosis. Leptin, secreted from adipose tissue, has diverse effects on bone tissue regulation. As glucocorticoids stimulate leptin synthesis and secretion directly in adipose tissue we hypothesised that dexamethasone (DEX) induced osteoporosis may, in part, be mediated by an osteoblast dependent leptin-leptin receptor pathway. Human bone cells expressed leptin and leptin receptors (Ob-Ra and Ob-Rb)...
2018: International Journal of Medical Sciences
Tianhong Su, Junbin Liao, Zihao Dai, Lixia Xu, Shuling Chen, Yifei Wang, Zhenwei Peng, Qiuyang Zhang, Sui Peng, Ming Kuang
Recent studies indicated that insufficient radiofrequency ablation (RFA) could endow hepatocellular carcinoma (HCC) with higher aggressive potential. Stress-induced phosphoprotein 1 (STIP1), which was found highly expressed in HCC, is a chaperone molecule mediating cell homeostasis under thermal stress. We aimed to explore the role of STIP1 on the metastasis of residual HCC after RFA. Mice model with orthotopic HCC implants or caudal vein injection were employed to assess potential of lung metastasis and/or intrahepatic metastasis (IHM) of HCC cells...
March 21, 2018: Oncogene
Sui-Ling Liao, Shih-Yun Hsu, Shen-Hao Lai, Shih-Hsiang Chen, Man-Chin Hua, Tsung-Chieh Yao, Li-Chen Chen, Ming-Han Tsai, Jing-Long Huang
Anemia is a major public health problem in young children. Reports on the role of anemia on infectious diseases remained controversial. We aim to investigate the effect of anemia on innate immunity, nasopharyngeal bacterial colonization, and subsequent infectious outcome. Blood tests were examined at the age of 12 months. TLR-induced cytokine production was assessed by ELISA. Bacteria from nasopharyngeal specimens were identified with traditional culture. Clinical infectious diseases were followed yearly until 3 years of age...
March 20, 2018: Scientific Reports
Jiaqing Luo, Hongchao Sun, Xianfeng Zhao, Suhua Wang, Xunhui Zhuo, Yi Yang, Xueqiu Chen, Chaoqun Yao, Aifang Du
The immunochromatographic test (ICT) is a convenient and low-cost method that can rapidly obtain results (10 min) under normal conditions. In this study, we established an ICT assay with two monoclonal antibodies: TgSAG3-3A7 and TgSAG3-4D5 based on the conserved protein of TgSAG3 that can be expressed in all the infective stages of T. gondii. 20 nm gold particles were prepared and conjugated with TgSAG3-3A7 MAb at the concentration of 12.5 μg/mL. TgSAG3-4D5 MAb were used as the capture antibody because of its higher affinity tested by ELISA...
March 15, 2018: Veterinary Parasitology
Xueyu Dou, Qing Zhou, Xiaohong Chen, Yeqiang Tan, Xin He, Ping Lu, Kunyan Sui, Ben Zhong Tang, Yongming Zhang, Wang Zhang Yuan
Nonconventional biomacromolecular luminogens have attracted extensive interests due to their fundamental importance and potential applications in diverse areas. To explore novel luminogens and moreover to gain deeper insights into their emission mechanism, we study the emission behaviors of sodium alginate (SA), a natural anionic polysaccharide composed of mannuronic (M) and guluronic acids (G). We find that the luminescence from aqueous SA solutions exhibits distinct concentration enhanced emission and aggregation-induced emission (AIE) characteristics...
March 20, 2018: Biomacromolecules
Francesco Plotti, Roberto Montera, Corrado Terranova, Daniela Luvero, Francesca Marrocco, Andrea Miranda, Alessandra Gatti, Carlo De Cicco Nardone, Roberto Angioli, Giuseppe Scaletta
OBJECTIVE: Implantation of bulking agents represents a noninvasive procedure for the treatment of stress urinary incontinence (SUI) in all patients where a more invasive procedure may increase perioperative risks. The primary aim of this retrospective study was to evaluate the efficacy over time of bulking agent implantation. As secondary aims, we evaluated long-term (patients' subjective) satisfaction rate, rate of de novo urinary symptoms, and the impact of urinary incontinence on the quality of life...
March 19, 2018: Menopause: the Journal of the North American Menopause Society
YanLi Xu, Yongxia Zhao, YaNan Sui, XiaoJun Lei
The present study was aimed to investigate the protective effect of Pterocarpus marsupium bark extracts against cataract in streptozotocin-induced diabetic male albino rats. Aldose reductase is a key enzyme in the intracellular polyol pathway, which plays a major role in the development of diabetic cataract. Rats were divided into five groups as normal control, diabetic control, and diabetic control treated with different concentrations of Pterocarpus marsupium bark extracts. Presence of major constituents in Pterocarpus marsupium bark extract was performed by qualitative analysis...
April 2018: 3 Biotech
Sándor Hornok, László Sugár, Isabel G Fernández de Mera, José de la Fuente, Gábor Horváth, Tibor Kovács, Attila Micsutka, Enikő Gönczi, Barbara Flaisz, Nóra Takács, Róbert Farkas, Marina L Meli, Regina Hofmann-Lehmann
BACKGROUND: Hunting constitutes an important industry in Europe. However, data on the prevalence of vector-borne bacteria in large game animal species are lacking from several countries. Blood or spleen samples (239 and 270, respectively) were taken from red, fallow and roe deer, as well as from water buffaloes, mouflons and wild boars in Hungary, followed by DNA extraction and molecular analyses for Anaplasma phagocytophilum, haemoplasmas and rickettsiae. RESULTS: Based on blood samples, the prevalence rate of A...
March 20, 2018: BMC Veterinary Research
Hsin-Yun Sun, Sui-Yuan Chang, Chien-Ching Hung
PURPOSE OF REVIEW: With prolonged life expectancy in HIV-positive patients on combination antiretroviral therapy, the quest for reducing lifelong drug exposure and minimizing or avoiding the toxicities of combination antiretroviral therapy while maintaining viral suppression has emerged when coformulations of antiretroviral agents with improved convenience, and better tolerability and efficacy became available. This review aims to update the current experience with the novel two-drug combination of dolutegravir (DTG) and rilpivirine (RPV) and elucidate the possible applications and limitations of coformulated DTG-RPV in the future...
March 16, 2018: Current Opinion in HIV and AIDS
Piran R Kidambi, Dhanushkodi D Mariappan, Nicholas T Dee, Andrey Vyatskikh, Sui Zhang, Rohit Karnik, A John Hart
Scalable, cost-effective synthesis and integration of graphene is imperative to realize large-area applications such as nanoporous atomically thin membranes (NATMs). Here, we report a scalable route to the production of NATMs via high-speed, continuous synthesis of large-area graphene by roll-to-roll chemical vapor deposition (CVD), combined with casting of a hierarchically porous polymer support. To begin, we designed and built a two zone roll-to-roll graphene CVD reactor, which sequentially exposes the moving foil substrate to annealing and growth atmospheres, with a sharp, isothermal transition between the zones...
March 19, 2018: ACS Applied Materials & Interfaces
Xiangyu Zhang, He Sui, Deyuan Zhang, Xinggang Jiang
High-speed ultrasonic vibration cutting (HUVC) has been proven to be significantly effective when turning Ti-6Al-4V alloy in recent researches. Despite of breaking through the cutting speed restriction of the ultrasonic vibration cutting (UVC) method, HUVC can also achieve the reduction of cutting force and the improvements in surface quality and cutting efficiency in the high-speed machining field. These benefits all result from the separation effect that occurs during the HUVC process. Despite the fact that the influences of vibration and cutting parameters have been discussed in previous researches, the separation analysis of HUVC should be conducted in detail in real cutting situations, and the tool geometry parameters should also be considered...
March 14, 2018: Ultrasonics
Ozan Dogan, Aski Ellibes Kaya, Cigdem Pulatoglu, Alper Basbug, Murat Yassa
INTRODUCTION AND HYPOTHESIS: There is a shortage of reliable data on the efficiency of the under-investigated mini-slings to treat stress urinary incontinence (SUI). We aimed to compare the effectiveness of the single-incision needleless mini-sling (SIMS) with the transobturator inside-out mid-urethral sling (TOT). MATERIALS AND METHODS: Two hundred one women with clinically proven SUI were included in this single-center prospective randomized trial. The patients were randomly allocated to the groups...
March 16, 2018: International Urogynecology Journal
Qi Sui, Peng Li, Ning-Ning Yang, Teng Gong, Ran Bu, En-Qing Gao
Since amines have high toxicity and exist widely, the development of selective sensing materials for amine detection has received considerable attentions. In this article, we demonstrate for the first time that a degree of discriminative detection of alkylamines can be achieved by a metal-organic coordination material. The material is derived from CdII and 4,4'-bipyridinium-1,1'-bis(phenylene-3-carboxylate), shows 1D channels lined with electron-deficient viologen chromophores, and exhibits different colors upon contact with amine vapors of different molecular sizes and types (primary, secondary and tertiary)...
March 16, 2018: ACS Applied Materials & Interfaces
Jiayu Chen, Barnaly Rashid, Qingbao Yu, Jingyu Liu, Dongdong Lin, Yuhui Du, Jing Sui, Vince D Calhoun
Imaging genetics posits a valuable strategy for elucidating genetic influences on brain abnormalities in psychiatric disorders. However, association analysis between 2D genetic data (subject × genetic variable) and 3D first-level functional magnetic resonance imaging (fMRI) data (subject × voxel × time) has been challenging given the asymmetry in data dimension. A summary feature needs to be derived for the imaging modality to compute inter-modality association at subject level. In this work, we propose to use variability in resting state networks (RSNs) and functional network connectivity (FNC) as potential features for purpose of association analysis...
2018: Frontiers in Neuroscience
Weiyang Chen, Longfa Fang, Xiahe Huang, Haitao Ge, Jinlong Wang, Xiaorong Wang, Yuanya Zhang, Na Sui, Wu Xu, Yingchun Wang
Differential expression of cold-responsive proteins is necessary for cyanobacteria to acclimate to cold stress frequently occurring in their natural habitats. Accumulating evidence indicates that cold-induced expression of certain proteins is dependent on light illumination, but a systematic identification of light-dependent and/or light-independent cold-responsive proteins in cyanobacteria is still lacking. Herein, we comprehensively identified cold-responsive proteins in a model cyanobacterium Synechocystis sp...
March 12, 2018: Journal of Proteomics
Tao Yu, Yonglian Zhang, Angela D Kerekes, Jayaram R Tagat, Ronald J Doll, Yushi Xiao, Sara Esposite, Alan Hruza, David B Belanger, Matthew Voss, Matthew P Rainka, Andrea Basso, Ming Liu, Lianzhu Liang, Ning Sui, Daniel Prelusky, Diane Rindgen, Likang Zhang
Imidazo-[1, 2-a]pyrazine 1 is a potent inhibitor of Aurora A and B kinase in vitro and is effective in in vivo tumor models, but has poor oral bioavailbility and is unsuitable for oral dosing. We describe herein our effort to improve oral exposure in this class, resulting ultimately in the identification of a potent Aurora inhibitor 16, which exhibited good drug exposure levels across species upon oral dosing, and showed excellent in vivo efficacy in a mouse xenograft tumor model when dosed orally.
February 23, 2018: Bioorganic & Medicinal Chemistry Letters
Hongjia Zhang, Tan Sui, Enrico Salvati, Dominik Daisenberger, Alexander J G Lunt, Kai Soon Fong, Xu Song, Alexander M Korsunsky
High energy 2D X-ray powder diffraction experiments are widely used for lattice strain measurement. The 2D to 1D conversion of diffraction patterns is a necessary step used to prepare the data for full pattern refinement, but is inefficient when only peak centre position information is required for lattice strain evaluation. The multi-step conversion process is likely to lead to increased errors associated with the 'caking' (radial binning) or fitting procedures. A new method is proposed here that relies on direct Digital Image Correlation analysis of 2D X-ray powder diffraction patterns (XRD-DIC, for short)...
March 15, 2018: Materials
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