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https://www.readbyqxmd.com/read/28319184/streptococcus-suis-sortase-a-is-ca2-independent-and-is-inhibited-by-acteoside-isoquercitrin-and-baicalin
#1
Fuguang Chen, Fang Xie, Baoling Yang, Chengcheng Wang, Siguo Liu, Yueling Zhang
Sortase A (SrtA) has long been recognized as an ideal drug target for therapeutic agents against Gram-positive pathogens. However, the SrtA of Streptococcus suis (Ss-SrtA), an important zoonotic agent, has not been studied. In this study, the enzymatic properties of Ss-SrtA were investigated, and inhibition of Ss-SrtA by natural products was evaluated. Ss-SrtA was expressed and purified. The purified recombinant Ss-SrtA had maximal activity at pH 6.0-7.5, 45°C, and showed a Km of 6.7 μM for the hydrolysis of substrate abz-LPATG-dnp...
2017: PloS One
https://www.readbyqxmd.com/read/28317986/experimental-and-theoretical-evidence-for-the-ferromagnetic-edge-in-wse2-nanosheets
#2
Lei Tao, Fanchen Meng, Shudong Zhao, Yongli Song, Jianxin Yu, Xianjie Wang, Zhiguo Liu, Yi Wang, Bingsheng Li, Yang Wang, Yu Sui
Bulk TMDCs are diamagnetic materials; however, two-dimensional TMDCs exhibit spin polarized edge states, which results in a coupling between the unsaturated transition metal and chalcogenide atoms at the edges. The magnetism in two-dimensional TMDCs broadens their applications in spintronic and multi-functional devices. Herein, by combining macro/micro-magnetic experimental measurements and density functional theory (DFT) calculations, we demonstrate that among five possible edge-terminated WSe2 nanosheets only two types have a magnetic ground state, corresponding to the 100% Se edge terminated and 50% Se edge terminated nanosheets, respectively...
March 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28315868/cerebellar-fastigial-nucleus-electrical-stimulation-alleviates-depressive-like-behaviors-in-post-stroke-depression-rat-model-and-potential-mechanisms
#3
Lei Zhang, Mingkui Zhao, Ru-Bo Sui
OBJECTIVE: To identify the molecular mechanism of post-stroke depression (PSD), and observe the therapeutic effects of cerebellar fastigial nucleus electrical stimulation (FNS) on the behaviors and regional cerebral blood flow (rCBF) in a PSD rat model. METHODS: Healthy SD rats were randomly divided into four groups (sham, stroke, post-stroke depress and FNS group). Sham group (n = 6) underwent sham operation. The other three groups (n = 6*3) underwent MCAO. Rats were examined twice a week in open filed test...
March 16, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28315496/remeex-device-external-mechanical-regulator-for-female-stress-urinary-incontinence-a-critical-review-of-a-single-operator-long-term-experience-on-implants-and-readjustments
#4
Franco Mantovani
OBJECTIVE: A single-operator, long-term (15 years) experience on a sling technique that allows a postoperative adjustment of its tension is presented to retrospectively report the objective and subjective outcomes in the treatment of female stress urinary incontinence (SUI). The readjustment option prevents the need of a reoperation in case of relapse with great compliance of the patients. MATERIALS AND METHODS: Indications for surgical tratment of SUI by ReMeEx included patients affected with not only true intrinsic sphyncteric deficency (ISD) and fixed urethra but also mild urethral hypermobility, previous incontinence surgery and relapsing conditions such as diabetes and obesity...
March 18, 2017: Urologia
https://www.readbyqxmd.com/read/28315168/aging-enhances-cognitive-biases-to-friends-but-not-the-self
#5
Jie Sui, Glyn W Humphreys
We measured changes in self and friend biases in perceptual matching in young and older participants. Participants learned associations between neutral geometric shapes and three personal labels (You, Friend, or Stranger), representing themselves, their named best friend, and a stranger not corresponding to anyone they knew. They then responded whether the shapes and labels matched or mismatched. In addition, participants reported the perceived personal distance between themselves, their best friend, and a stranger...
March 17, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28314100/attenuated-mtor-signaling-and-enhanced-glucose-homeostasis-by-dietary-supplementation-with-lotus-seedpod-oligomeric-procyanidins-in-streptozotocin-stz-induced-diabetic-mice
#6
Xiaopeng Li, Yong Sui, Qian Wu, Bijun Xie, Zhida Sun
This study investigated the protective role of lotus seedpod oligomeric procyanidins (LSOPC) and synbiotics (Bifidobacterium Bb-12 and xylo-oligosaccharide) against high fat and streptozotocin (STZ)-induced diabetes. Administration of LSOPC or synbiotics have no effect on blood glucose in normal mice. Treatments with LSOPC for 12 weeks markedly reduced blood glucose, FFA, endotoxin, GHbA1c and improved glucose homeostasis, lipid metabolism and insulin level. In addition, administration of LSOPC significantly reversed the increase of mTOR and p66Shc in liver, skeletal muscle and white adipose tissue (WAT)...
March 17, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28314074/better-understanding-of-homologous-recombination-through-a-12-week-laboratory-course-for-undergraduates-majoring-in-biotechnology
#7
Ming Li, Xiaodong Shen, Yan Zhao, Xiaomei Hu, Fuquan Hu, Xiancai Rao
Homologous recombination, a central concept in biology, is defined as the exchange of DNA strands between two similar or identical nucleotide sequences. Unfortunately, undergraduate students majoring in biotechnology often experience difficulties in understanding the molecular basis of homologous recombination. In this study, we developed and implemented a 12-week laboratory course for biotechnology undergraduates in which gene targeting in Streptococcus suis was used to facilitate their understanding of the basic concept and process of homologous recombination...
March 17, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28303850/incidence-and-risk-factors-of-de-novo-stress-urinary-incontinence-after-pelvic-floor-reconstruction-a-nested-case-control-study
#8
Shi-Yan Wang, Ting-Ting Cao, Run-Zhi Wang, Xin Yang, Xiu-Li Sun, Jian-Liu Wang
BACKGROUND: Some patients with pelvic organ prolapse may suffer from lower urinary tract symptoms (LUTS), especially stress urinary incontinence (SUI) named de novo SUI after pelvic floor reconstruction. This study aimed to investigate the incidence and risk factors of de novo SUI. METHODS: This is a nested case-control study of 533 patients who underwent pelvic floor reconstruction due to pelvic organ prolapse (POP) at the Department of Gynecology in Peking University People's Hospital from January 2011 to March 2013...
March 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28302221/-distant-metastasis-and-survival-outcomes-after-computed-tomography-guided-needle-biopsy-in-stage-i-ii-non-small-cell-lung-cancer
#9
Jingli Fan, Keke Zhai, Tingting Ren, Xiao Feng, Lin Sui, Jing Hu, Qingwei Meng
BACKGROUND: Computed tomography-guided needle biopsy (CTNB) is a well-established and commonly used technique for diagnosing pulmonary nodules with high accuracy and safety. Needle-tract implantation after CTNB has been reported in various reports. The aim of this study is to evaluate whether preoperative CTNB affected the distant metastasis and overall survival in pathological stage I-II lung cancer patients. METHODS: A total of 1,234 patients with pathological stage I-II non-small cell lung cancer were collected...
March 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28301535/quantitative-assessment-of-pulmonary-alveolar-proteinosis-pap-with-ultra-dose-ct-and-correlation-with-pulmonary-function-tests-pfts
#10
Xin Sui, Qianni Du, Kai-Feng Xu, Xinlun Tian, Lan Song, Xiao Wang, Xiaoli Xu, Zixing Wang, Yuyan Wang, Jun Gu, Wei Song, Zhengyu Jin
BACKGROUND: The purpose of this study was to investigate whether ultra-low-dose chest computed tomography (CT) can be used for visual assessment of CT features in patients with pulmonary alveolar proteinosis (PAP) and to evaluate the relationship between the quantitative analysis of the ultra-low-dose CT scans and the pulmonary function tests (PFTs). METHODS: Thirty-eight patients (mean [SD] age, 44.47 [12.28] years; 29 males, 9 females) with PAP were enrolled and subjected to two scans each with low-dose CT (reference parameters: 120 kV and 50 mAs) and ultra-low-dose CT (reference parameters, 80 kV, 25 mAs)...
2017: PloS One
https://www.readbyqxmd.com/read/28300645/boar-hunting-and-brucellosis-caused-by-brucella-suis
#11
REVIEW
Carlos Franco-Paredes, Daniel Chastain, Peter Taylor, Stephen Stocking, Brenda Sellers
Brucellosis remains as a significant public health concern in many areas where the infection persists in domestic hosts (i.e. goats, cattle, and domestic swine) with subsequent risk of transmission to human populations. Brucellosis caused by B. suis remains an important threat to human populations in many countries exposed to domestic and feral swine. In the U.S., swine brucellosis has been under control for many years. Meanwhile, it is a widespread infection among feral swine, particularly in the Southeastern United States; and exposure to infected animals pose a growing threat to humans...
March 12, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/28300153/brucella-spp-of-amphibians-comprise-genomically-diverse-motile-strains-competent-for-replication-in-macrophages-and-survival-in-mammalian-hosts
#12
Sascha Al Dahouk, Stephan Köhler, Alessandra Occhialini, María Pilar Jiménez de Bagüés, Jens Andre Hammerl, Tobias Eisenberg, Gilles Vergnaud, Axel Cloeckaert, Michel S Zygmunt, Adrian M Whatmore, Falk Melzer, Kevin P Drees, Jeffrey T Foster, Alice R Wattam, Holger C Scholz
Twenty-one small Gram-negative motile coccobacilli were isolated from 15 systemically diseased African bullfrogs (Pyxicephalus edulis), and were initially identified as Ochrobactrum anthropi by standard microbiological identification systems. Phylogenetic reconstructions using combined molecular analyses and comparative whole genome analysis of the most diverse of the bullfrog strains verified affiliation with the genus Brucella and placed the isolates in a cluster containing B. inopinata and the other non-classical Brucella species but also revealed significant genetic differences within the group...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28299321/jianpi-jiedu-recipe-inhibits-epithelial-to-mesenchymal-transition-in-colorectal-cancer-through-tgf-%C3%AE-smad-mediated-snail-e-cadherin-expression
#13
Xuan Liu, Qing Ji, Wanli Deng, Ni Chai, Yuanyuan Feng, Lihong Zhou, Hua Sui, Chunpu Li, Xiaoting Sun, Qi Li
JPJD was an ideal alternative traditional Chinese medicine compound in the prevention and treatment of CRC, but its underlying mechanisms has not been fully elucidated. In this study, we demonstrated in vitro that TGF-β-induced EMT promoted the invasion and metastasis of CRC cells, reduced the expression of E-cadherin, and elevated the expression of Vimentin. However, JPJD could inhibit the invasive and migratory ability of TGF-β-stimulated CRC cells in a concentration-dependent manner through increasing the expression of E-cadherin and repressing the expression of Vimentin, as well as the inhibition of TGF-β/Smad signaling pathway...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28296306/a-novel-phantom-and-procedure-providing-submillimeter-accuracy-in-daily-qa-tests-of-accelerators-used-for-stereotactic-radiosurgery
#14
Ivan A Brezovich, Richard A Popple, Jun Duan, Sui Shen, Xingen Wu, Sidi Benhabib, Mi Huang, Rex A Cardan
Stereotactic radiosurgery (SRS) places great demands on spatial accuracy. Steel BBs used as markers in quality assurance (QA) phantoms are clearly visible in MV and planar kV images, but artifacts compromise cone-beam CT (CBCT) isocenter localization. The purpose of this work was to develop a QA phantom for measuring with sub-mm accuracy isocenter congruence of planar kV, MV, and CBCT imaging systems and to design a practical QA procedure that includes daily Winston-Lutz (WL) tests and does not require computer aid...
July 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28294459/identifying-dynamic-functional-connectivity-biomarkers-using-gig-ica-application-to-schizophrenia-schizoaffective-disorder-and-psychotic-bipolar-disorder
#15
Yuhui Du, Godfrey D Pearlson, Dongdong Lin, Jing Sui, Jiayu Chen, Mustafa Salman, Carol A Tamminga, Elena I Ivleva, John A Sweeney, Matcheri S Keshavan, Brett A Clementz, Juan Bustillo, Vince D Calhoun
Functional magnetic resonance imaging (fMRI) studies have shown altered brain dynamic functional connectivity (DFC) in mental disorders. Here, we aim to explore DFC across a spectrum of symptomatically-related disorders including bipolar disorder with psychosis (BPP), schizoaffective disorder (SAD), and schizophrenia (SZ). We introduce a group information guided independent component analysis procedure to estimate both group-level and subject-specific connectivity states from DFC. Using resting-state fMRI data of 238 healthy controls (HCs), 140 BPP, 132 SAD, and 113 SZ patients, we identified measures differentiating groups from the whole-brain DFC and traditional static functional connectivity (SFC), separately...
March 10, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28292261/genome-wide-analysis-of-a-avirulent-and-reveal-the-strain-induces-pro-tective-immunity-against-challenge-with-virulent-streptococcus-suis-serotype-2
#16
Jing Wang, Youjun Feng, Changjun Wang, Feng Zheng, Bachar Hassan, Liming Zhi, Wenjuan Li, Yi Yao, Elaine He, Shibo Jiang, Jiaqi Tang
BACKGROUND: It was previously reported in China that two recent large-scale outbreaks of Streptococcus suis serotype 2 (S. suis 2) infections in human were caused by two highly virulent S. suis 2 strains, from which a novel genomic island (GEI), associated with disease onset and progression and designated 89 K, was identified. Here, an avirulent strain, 05HAS68, was isolated from a clinically healthy pig. RESULTS: By comparing the genomes of this avirulent strain with virulent strains, it was found that massive genomic rearrangements occurred, resulting in alterations in gene expression that caused enormous single gene gain and loss...
March 14, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28290617/digital-expression-analysis-of-the-genes-associated-with-salinity-resistance-after-overexpression-of-a-stress-responsive-small-gtp-binding-rabg-protein-in-peanut
#17
J M Sui, G Li, G X Chen, M Y Yu, S T Ding, J S Wang, L X Qiao
The Rab protein family is the largest family of the small GTP-binding proteins. Among them, the RabG genes are known to be responsive to abiotic stresses, but the molecular mechanisms of the stress responses mediated by RabG genes in plants is poorly understood. To investigate the molecular mechanism of AhRabG gene in peanut, transgenic plants overexpressing the AhRabG gene (S6) with relatively higher salinity resistance than the non-transgenic plants (S7) were obtained. Digital gene expression (DGE) sequencing was performed with the leaves of S6 and S7 plants before and after salinity-stress treatment...
March 8, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28289954/characterizing-the-impact-of-surfactant-structure-on-interfacial-tension-a-molecular-dynamics-study
#18
Zi-Yu Liu, Ce Wang, He Zhou, Yanlei Wang, Lei Zhang, Lu Zhang, Sui Zhao
The effect of sodium branched-alkylbenzene sulfonates on the NaCl solution/oil interface was studied via classical molecular dynamics simulation. The interfacial properties were found to depend on the surfactant concentration and to change dramatically when the concentration exceeded a critical value, the simulated limit area (A c). When A c is not close to the theoretical saturated adsorption area (A min), the surfactant cannot produce ultralow interfacial tension (IFT). When A c is equal or almost equal to A min, the effect of the structure of the surfactant must be considered to determine if ultralow IFT is possible: if the sizes of the hydrophobic and hydrophilic groups in the surfactant are similar, the surfactant can produce ultralow interfacial tension (and vice versa)...
April 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28286067/future-directions-of-research-and-care-for-urinary-incontinence-in-women-findings-from-the-national-institute-of-diabetes-and-digestive-and-kidney-diseases-niddk-summit-on-urinary-incontinence-clinical-research-in-women
#19
REVIEW
Toby C Chai, Tirsit S Asfaw, Jan E Baker, Becky Clarkson, Pamela Coleman, Susan Hoffstetter, Kimberly Konkel, Missy Lavender, Shailaja Nair, Jenna Norton, Leslee Subak, Anthony Visco, Robert A Star, Tamara Bavendam
PURPOSE: Female urinary incontinence (UI) is prevalent, costly, and morbid. Participants in an NIDDK-sponsored summit reviewed findings from NIH-funded clinical research in UI and discussed the future of UI research. MATERIALS AND METHODS: On March 14 2014, the NIDDK convened a "Summit on Urinary Incontinence Clinical Research in Women." Participants representing a broad range of clinical expertise reviewed completed, NIH-sponsored UI-related studies, including results from community-based, epidemiologic studies such as the Boston Area Community Health (BACH) Survey and from randomized clinical trials such as the Program to Reduce Incontinence by Diet and Exercise (PRIDE) and studies conducted by the Pelvic Floor Disorders Network (PFDN) and the Urinary Incontinence Treatment Network (UITN)...
March 9, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28285911/evaluation-of-anti-diabetic-effect-and-gall-bladder-function-with-2-thio-5-thiomethyl-substituted-imidazoles-as-tgr5-receptor-agonists
#20
Xuqing Zhang, Zhihua Sui, Jack Kauffman, Cuifen Hou, Cailin Chen, Fuyong Du, Thomas Kirchner, Yin Liang, Dana Johnson, William V Murray, Keith Demarest
A novel series of 2-thio-5-thiomethyl substituted imidazoles was discovered to be potent TGR5 agonists that possessed glucose-lowering effects while inhibiting gall bladder emptying in mice.
February 28, 2017: Bioorganic & Medicinal Chemistry Letters
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