keyword
https://read.qxmd.com/read/38536068/best-overall-response-associated-signature-to-doxorubicin-in-soft-tissue-sarcomas-a-transcriptomic-analysis-from-announce
#1
JOURNAL ARTICLE
Jiangang Liu, David S Moura, Robin L Jones, Amit Aggarwal, Ebert J Philip, Andrew J Wagner, Jennifer Wright, Javier Martín-Broto, William D Tap
PURPOSE: This exploratory analysis evaluated the tumor samples of the patients treated with doxorubicin (with or without olaratumab) in a negative phase-3 ANNOUNCE trial to better understand the complexity of advanced soft tissue sarcomas (STS) and to potentially identify its predictive markers. EXPERIMENTAL DESIGN: RNA sequencing was performed on pretreatment tumor samples (n=273) from the ANNOUNCE trial to evaluate response patterns and identify potential predictive treatment markers for doxorubicin...
March 27, 2024: Clinical Cancer Research
https://read.qxmd.com/read/38534214/anti-cd99-antibody-therapy-triggers-macrophage-dependent-ewing-cell-death-in-vitro-and-myeloid-cell-recruitment-in-vivo
#2
JOURNAL ARTICLE
Allison F O'Neill, Evelyn M Nguyen, Evelyn D Maldonado, Matthew R Chang, Jiusong Sun, Quan Zhu, Wayne A Marasco
BACKGROUND: Ewing sarcoma is a rare tumor of the bone or soft tissues characterized by diffuse membranous staining for CD99. As this tumor remains incurable in the metastatic, relapsed, and refractory settings, we explored the downstream immune implications of targeting CD99. METHODS: We discovered a human anti-CD99 antibody (NOA2) by phagemid panning and investigated NOA2 immune cell-mediated cytotoxicity in vitro and in vivo focusing on the myeloid cell compartment, given that M2 macrophages are present in human tumors and associated with a poor prognosis...
March 18, 2024: Antibodies
https://read.qxmd.com/read/38534077/synovial-sarcoma-of-the-viscera-lung-and-jejunum-a-case-report
#3
JOURNAL ARTICLE
Jixin He, Jiwei Wang, Lina Yang, Kai Wang, Maijian Wang, Jianguo Li
We report the case of a woman nearing 70 years old who was admitted to the hospital with a complaint of "epigastric distension for 1 month". Her main signs and symptoms were progressive abdominal distension and occasional abdominal pain. Computed tomography suggested an abdominal mass. She had a surgical history of synovial sarcoma (SS) of the lungs. After admission, she was diagnosed with jejunal SS following a puncture biopsy and laparoscopic surgery. This disease usually occurs in the soft tissues of the limbs, and it is extremely rare for SS to originate in the jejunum...
March 2024: Journal of International Medical Research
https://read.qxmd.com/read/38533914/recycled-bone-grafts-treated-with-extracorporeal-irradiation-or-liquid-nitrogen-freezing-after-malignant-tumor-resection
#4
JOURNAL ARTICLE
Yuta Takeuchi, Akio Sakamoto, Takashi Noguchi, Junya Toguchida, Shuichi Matsuda
INTRODUCTION: Recycled bone autografts prepared using extracorporeal irradiation (ECIR) or liquid nitrogen freezing (LNF) methods have been used for the reconstruction of skeletal elements after wide resection of sarcomas involving bone tissues. Few reports include long-term follow-up data for histological analyses of recycled autografts, particularly in the case of ECIR autografts. MATERIALS: A total of 34 malignant bone and soft tissue tumors were resected and reconstructed using 11 ECIR- and 23 LNF-recycled autografts; the mean postoperative follow-ups were 14 and 8 years, respectively...
March 27, 2024: Journal of Surgical Oncology
https://read.qxmd.com/read/38533803/mitotic-activity-a-systematic-literature-review-of-the-assessment-methodology-and-prognostic-value-in-feline-tumors
#5
JOURNAL ARTICLE
Christof A Bertram, Taryn A Donovan, Alexander Bartel
Increased proliferation is a driver of tumorigenesis, and quantification of mitotic activity is a standard task for prognostication. This systematic review is an analysis of all available references on mitotic activity in feline tumors to provide an overview of the assessment methods and prognostic value. A systematic literature search in PubMed and Scopus and a nonsystematic search in Google Scholar were conducted. All articles on feline tumors that correlated mitotic activity with patient outcome were identified...
March 27, 2024: Veterinary Pathology
https://read.qxmd.com/read/38531939/ultra-low-dose-computed-tomography-and-chest-x-ray-in-follow-up-of-high-grade-soft-tissue-sarcoma-a-prospective-comparative-study
#6
JOURNAL ARTICLE
Samuli Salminen, Sari Jäämaa, Riikka Nevala, Markus J Sormaala, Mika Koivikko, Erkki Tukiainen, Jussi Repo, Carl Blomqvist, Mika Sampo
Ultra-low-dose computed tomography (ULD-CT) may combine the high sensitivity of conventional computed tomography (CT) in detecting sarcoma pulmonary metastasis, with a radiation dose in the same magnitude as chest X-ray (CXR). Fifty patients with non-metastatic high-grade soft tissue sarcoma treated with curative intention were recruited. Their follow-up involved both CXR and ULD-CT to evaluate their different sensitivity. Suspected findings were confirmed by conventional CT if necessary. Patients with isolated pulmonary metastases were treated with surgery or stereotactic body radiation therapy (SBRT) with curative intent if possible...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531265/a-recurrent-ntrk1-tyrosine-kinase-domain-mutation-pair-is-characteristic-in-a-subset-of-dedifferentiated-liposarcomas
#7
JOURNAL ARTICLE
Zoltán Lippai, Bálint Péterfia, Gergő Papp, Katalin Dezső, Gábor Bedics, Zsuzsanna Pápai, Meindert H Lamers, Rosan Cm Kuin, Károly Szuhai, Zoltán Sápi
INTRODUCTION: Dedifferentiated liposarcoma (DDLPS) is a common form of liposarcoma with challenging treatment modalities. Pan-TRK immunopositivity can be often observed without NTRK gene fusion in soft tissue sarcomas with myogenic differentiation. Expression and the role of NTRK in DDLPS are under-studied. We sought to identify activating mutations of the NTRK genes. MATERIALS AND METHODS: 131 DDLPS patients were selected for pan-TRK immunohistochemistry and positive cases were analyzed by Sanger sequencing for NTRK1, NTRK2 and NTRK3 genes...
March 14, 2024: European Journal of Cancer
https://read.qxmd.com/read/38527792/clinical-activity-in-general-practice-prior-to-sarcoma-diagnosis-australian-cohort-study
#8
JOURNAL ARTICLE
Meena Rafiq, Jasper de Boer, Jasmine Mar, Jayesh Desai, Susie Bae, David E Gyorki, Claudia Di Bella, Georgios Lyratzopoulos, Jeremy Lewin, Jon Emery
Background Increased time-to-diagnosis in sarcoma is associated with poor prognosis and patient outcomes. Research is needed to identify if opportunities to expedite the diagnosis of sarcoma in general practice (GP) exist. Aim To examine pre-diagnostic GP clinical activity prior to sarcoma diagnosis. Design and Setting An Australian retrospective cohort study using hospital registry data (Australian Comprehensive Cancer Outcomes and Research Database) linked to two primary care datasets (Patron and MedicineInsight)...
March 25, 2024: British Journal of General Practice
https://read.qxmd.com/read/38527318/benefits-of-collaboration-between-the-wound-ostomy-and-continence-nurse-and-orthopedic-surgeon-when-treating-skin-defects-after-soft-tissue-sarcoma-resection-a-retrospective-case-control-study
#9
JOURNAL ARTICLE
Hiromi Sasaki, Tomoyo Nishiobino, Hiroyuki Tominaga, Akihiro Tokushige, Naohiro Shinohara, Satoshi Nagano, Noboru Taniguchi
PURPOSE: The purpose of this study was to evaluate the benefits of collaborative management between orthopedic surgery and WOC nurses in patients undergoing resection of subcutaneous sarcomas. DESIGN: Retrospective case-control study. SUBJECTS AND SETTING: The sample comprised 25 patients who underwent wide resection for soft tissue sarcoma, followed by 2-stage split-thickness skin grafting. Data collection occurred between January 2015 and April 2021 in a university hospital based in Kagoshima, Japan...
March 2024: Journal of Wound, Ostomy, and Continence Nursing
https://read.qxmd.com/read/38526767/a-comparison-of-clear-cell-sarcoma-to-jaw-and-salivary-tumors-bearing-ews-fusions
#10
REVIEW
Ornela Xhori, Navkiran Deol, Camron M Rivera, Jason Zavras, Sophia G Weil, Hirad Zafari, Julia C Thierauf, William C Faquin, Edwin Choy, Miguel N Rivera, A John Iafrate, Alexandre Jaquinet, Maria J Troulis
OBJECTIVE: To review tumors identified as "clear cell sarcoma" in order to determine similarities to the rare EWS fusion positive jaw and salivary gland tumors clear cell odontogenic carcinoma (CCOC) and clear cell carcinoma of the salivary gland (CCC). METHODS: PubMed was used to collect all reports of clear cell sarcoma (CCS). Search parameters were "clear cell sarcoma" and "CCS." References in the publications were screened and cross-referenced. Data extracted included demographic characteristics, presenting signs and symptoms, radiographic findings, histological and immunohistochemical features and known molecular/genetic aberrations...
March 25, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38525823/primary-ntrk-rearranged-spindle-cell-neoplasm-of-the-gastrointestinal-tract-a-clinicopathological-and-molecular-analysis-of-8-cases
#11
JOURNAL ARTICLE
Xiaojiao Gao, Song Xu, Peipei Zhu, I Weng Lao, Lin Yu, Jian Wang
NTRK-rearranged spindle cell neoplasm occurs predominantly in the superficial or deep soft tissues of extremities or trunk. Occurrence in the visceral organs is extremely rare. Herein, we describe 8 cases of NTRK-rearranged spindle cell neoplasm that arose primarily in the gastrointestinal tract. Patients included 5 males and 3 females with age at presentation ranging from 6 to 63 years (median: 29.5 years). Tumors occurred in the colon (n=3), small intestine (n=2), rectum (n=2), and stomach (n=1). Tumor size ranged from 3...
March 25, 2024: American Journal of Surgical Pathology
https://read.qxmd.com/read/38524524/misdiagnosis-of-synovial-sarcoma-cellular-myofibroma-with-srf-rela-gene-fusion-a-case-report
#12
Ying Zhou, Yi-Wen Sun, Xiao-Yang Liu, Dan-Hua Shen
BACKGROUND: Cellular myofibroma is a rare subtype of myofibroma that was first described in 2017. Its diagnosis is often challenging because of its relative rarity, lack of known genetic abnormalities, and expression of muscle markers that can be confused with sarcomas that have myogenic differentiation. Currently, scholars have limited knowledge of this disease, and published cases are few. Further accumulation of diagnostic and treatment experiences is required. CASE SUMMARY: A 16-year-old girl experienced left upper limb swelling for 3 years...
March 6, 2024: World Journal of Clinical Cases
https://read.qxmd.com/read/38523942/a-rare-case-of-spindle-cell-sarcoma-with-rare-asymptomatic-cerebellar-metastasis
#13
Candace Miyaki, Kathie Wu, David Nye, Nadia Ramdin
Sarcomas are one of the rarest cancers, occurring in less than 1% of all adult malignancies. Spindle cell sarcomas are one subset of soft tissue sarcomas that are even less commonly reported in the literature due to the scarcity of cases, especially with the presence of brain metastases. We present a case of an adult male who presented with non-specific exertional dyspnea and chest pain, which was found to have spindle cell sarcoma with cerebellar metastasis.
February 2024: Curēus
https://read.qxmd.com/read/38523425/managing-suspected-myasthenia-gravis-and-myositis-induced-by-pembrolizumab-in-a-jehovah-s-witness-sarcoma-patient
#14
JOURNAL ARTICLE
Alexander Hutchinson, Danielle Eskens, Abigail Chan, Anika Bhargava, Ryan Bycroft
INTRODUCTION: Immune checkpoint inhibitors (ICIs) can cause a spectrum of adverse events known as immune-related adverse events (irAEs) that resemble autoimmune responses. Immune-mediated myasthenia gravis (MG) is a rare and serious neurologic adverse event that has been associated with ICIs requiring prompt treatment. In the Jehovah's Witness population, typical management of these adverse events may not be options, and alternative treatment choices would be needed. CASE REPORT: 73-year-old Jehovah's Witness patient with high-grade undifferentiated pleiomorphic sarcoma who developed immune-mediated MG approximately 4 weeks after initiation of pembrolizumab...
March 24, 2024: Journal of Oncology Pharmacy Practice
https://read.qxmd.com/read/38523398/anaplastic-large-cell-lymphoma-with-alk-atic-fusion-mimicking-a-histiocytic-sarcoma-debuting-as-an-anterior-thoracic-soft-tissue-tumor-with-exceptional-clinicopathological-morphological-and-molecular-features
#15
José Antonio García-Muñiz, Natalia Vilches-Cisneros, Juan Pablo Flores-Gutiérrez, Oralia Barboza-Quintana
A 56-year-old woman debuted with a palpable painless mass in the anterior thorax wall at the level of the second and third right parasternal intercostal space, which progressively increased in size over 5 months accompanied by localized skin rash, mild dyspnea and chest pain when changing position. Imaging studies showed a soft tissue mass measuring 75 × 62 mm and a density of 34 Hounsfield Units that had caused the lysis of the costal arches and grew expansively towards the anterior mediastinum, without identifying mediastinal adenopathies only by this imaging method...
March 24, 2024: Thoracic Cancer
https://read.qxmd.com/read/38522331/enhanced-accuracy-and-reduced-delay-in-diagnosing-bone-tumors-within-an-expert-sarcoma-network-a-nationwide-study
#16
JOURNAL ARTICLE
Vincent Crenn, François Lataste, Louise Galmiche, Louis-Romée Le Nail, Mickaël Ropars, Jean-Yves Blay, Gonzague de Pinieux, Francois Gouin
INTRODUCTION: Primary bone tumors encompass a range of rare and diverse lesions. Pathological diagnosis poses significant challenges, with histological discrepancies extensively studied in soft tissue sarcomas but lacking specific investigation in bone lesions. This study aimed to determine the rate of major diagnostic discrepancies in primary bone tumors, assessing whether initial histological analysis within an expert referral center network reduces this rate and final diagnostic delay...
March 18, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38521902/surgical-management-of-urethral-obstruction-secondary-to-perineal-liposarcoma-in-a-dog-a-case-report
#17
JOURNAL ARTICLE
Natália Korytárová, Beate Bosch, Luise Grace Klass, Pavel Slunsky
BACKGROUND: Swelling of the perineal region in male dogs is most commonly caused by a perineal hernia. Clinical signs associated with perineal hernia are constipation, tenesmus or stranguria. This case report documents a rare cause of perineal swelling created by the growth of a malignant tumour leading to urethral obstruction and subsequent stranguria. CASE PRESENTATION: An 11-year-old neutered male German Shepherd was presented for swelling in the perineal region and stranguria for three days...
March 23, 2024: BMC Veterinary Research
https://read.qxmd.com/read/38521760/sequential-multimodal-treatments-with-chemotherapy-and-surgery-for-advanced-soft-tissue-sarcoma-may-be-associated-with-better-survival-than-chemotherapy
#18
JOURNAL ARTICLE
Ching-Tso Chen, Hsing-Wu Chen, Wei-Hsin Lin, Pei-Ming Huang, Mong-Wei Lin, Ching-Yao Yang, Che-Yu Hsu, Chia-Chun Wang, Jen-Chieh Lee, Koping Chang, Kuo-Hao Huang, Ho-Min Chen, Tom Wei-Wu Chen, Rong-Sen Yang, Ruey-Long Hong
BACKGROUND: In patients with advanced soft tissue sarcoma (STS), surgery had been reported to be associated with superior overall survival (OS). Chemotherapy details for such patients were less reported, and whether multimodal treatment with surgery and chemotherapy provides extra survival benefit remains unclear. METHODS: We retrospectively reviewed patients with newly diagnosed advanced STS treated at National Taiwan University Hospital from January 1, 2011, to December 31, 2017...
March 23, 2024: Journal of the Formosan Medical Association
https://read.qxmd.com/read/38521373/back-to-the-future-selected-bone-and-soft-tissue-neoplasms-with-shared-genetic-alterations-but-differing-morphological-and-immunohistochemical-phenotypes
#19
REVIEW
Nooshin K Dashti, Casey P Schukow, Scott E Kilpatrick
Bone and soft tissue tumors (BST) are a highly heterogeneous group largely classified by their line of differentiation, based on their resemblance to their normal counterpart in adult tissue. Yet, rendering a specific diagnosis can be challenging, primarily due to their rarity and overlapping histopathologic features or clinical presentations. Over the past few decades, seemingly histogenetic-specific gene fusions/translocations and amplifications have been discovered, aiding in a more nuanced classification, leading to well-established objective diagnostic criteria and the development of specific surrogate ancillary tests targeting these genetic aberrations (e...
March 21, 2024: Human Pathology
https://read.qxmd.com/read/38521165/neutrophil-to-lymphocyte-ratio-for-the-prediction-of-soft-tissue-sarcomas-response-to-pre-operative-radiation-therapy
#20
JOURNAL ARTICLE
Constanza Martinez, Rie Asso, Neelabh Rastogi, Carolyn Freeman, Fabio Cury
PURPOSE/OBJECTIVE: This study aims to assess the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) in soft tissue sarcomas (STS) treated with pre-operative hypofractionated radiotherapy (HFRT). MATERIALS/METHODS: This retrospective analysis included patients treated with pre-operative HFRT of 30 Gy in 5 fractions between 2016 and 2023. Clinical, demographic, and complete blood count (CBC) data were collected. NLR was calculated by dividing the absolute neutrophil count by the absolute lymphocyte count...
March 21, 2024: Radiotherapy and Oncology
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