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Leukodistrophy

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https://www.readbyqxmd.com/read/24962806/changes-of-statistical-structural-fluctuations-unveils-an-early-compacted-degraded-stage-of-pns-myelin
#1
Nicola Poccia, Gaetano Campi, Alessandro Ricci, Alessandra S Caporale, Emanuela Di Cola, Thomas A Hawkins, Antonio Bianconi
Degradation of the myelin sheath is a common pathology underlying demyelinating neurological diseases from Multiple Sclerosis to Leukodistrophies. Although large malformations of myelin ultrastructure in the advanced stages of Wallerian degradation is known, its subtle structural variations at early stages of demyelination remains poorly characterized. This is partly due to the lack of suitable and non-invasive experimental probes possessing sufficient resolution to detect the degradation. Here we report the feasibility of the application of an innovative non-invasive local structure experimental approach for imaging the changes of statistical structural fluctuations in the first stage of myelin degeneration...
2014: Scientific Reports
https://www.readbyqxmd.com/read/23105697/x-linked-adreno-leukodistrophy-profiles-of-very-long-chain-fatty-acids-in-plasma-and-fibroblasts-in-eigth-serbian-patients
#2
Sanja Grkovic, Rajko Nikolic, Maja Djordjevic, Ljubomir Stojanov, Snezana Zivancevic-Simonovic, Gordana Djordjevic-Denic, Bozica Kecman
X-linked adrenoleukodistrophy is a severe neurodegenerative disorder with impaired very long chain fatty acid metabolism. The disease associated ABCD1 gene encodes a peroxisomal membrane protein which belongs to the superfamily of ATP-binding cassette transporters. We investigated eight male X-ALD patients diagnosed among 142 suspected patients referred for investigation. Plasma levels of very long chain fatty acids were measured at our laboratory using capillary gas chromatography. Eight cases of childhood X-ALD were diagnosed...
September 2007: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/12461688/molecular-and-biochemical-characterisation-of-a-novel-sulphatase-gene-arylsulfatase-g-arsg
#3
Paola Ferrante, Silvia Messali, Germana Meroni, Andrea Ballabio
Molecular analysis has provided important insights into the biochemistry and genetics of the sulphatase family of enzymes. Through bioinformatic searches of the EST database, we have identified a novel gene consisting of 11 exons and encoding a 525 aa protein that shares a high degree of sequence similarity with all sulphatases and in particular with arylsulphatases, hence the tentative name Arylsulfatase G (ARSG). The highest homology is shared with Arylsulfatase A, a lysosomal sulphatase which is mutated in metachromatic leukodistrophy, particularly in the amino-terminal region...
December 2002: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/1907757/-hereditary-lysosomal-diseases-in-mexico-iii-laboratory-diagnosis-of-sphingolipidosis
#4
M E Zetina, A González-Noriega
Enzymatic determinations of the levels of lysosomal enzymes in serum or leukocytes samples have been carried out for the diagnosis of 7 sphingolipidosis. This methodology has allowed us to study 49 homozygotes and 33 close relatives at risk for the carrier state of a particular sphingolipidosis. So far we have diagnosed: 21 Gaucher's disease patients, 17 metachromatic leukodistrophy, 4 Niemann-Pick, 4 GM2 gangliosidosis, 2 Fabry and one GM1 gangliosidosis. Limitations in the performance and interpretation of the levels of the defective enzyme in heterozygotes, homozygotes and those variants not detected with the assays described are discussed...
January 1991: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
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