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https://www.readbyqxmd.com/read/28335082/reporting-of-mitotic-rate-in-cutaneous-melanoma-a-study-using-the-national-cancer-data-base
#1
Patrick D Lorimer, Emily C Benham, Kendall Walsh, Yimei Han, Meghan R Forster, Terry Sarantou, Richard L White, Joshua S Hill
BACKGROUND: The seventh edition of the American Joint Commission on Cancer staging manual (AJCC7, published 2009), updated thin cutaneous melanoma staging protocols with the incorporation of mitotic rate (MR). In these patients, higher MR is associated with decreased survival. This study utilizes the National Cancer Data Base (NCDB) to evaluate MR reporting since AJCC7. METHODS: The NCDB was queried for patients with primary cutaneous melanoma from 1998 to 2013...
March 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28335059/retrospective-evaluation-of-percutaneous-access-for-tevar-and-evar-time-to-make-it-the-standard-approach
#2
Rohit Philip Thomas, Tobias Kowald, Bernhard Schmuck, Osama Eldergash, Andreas Klausen, Valentin Dikov, Jerry Easo, Ajay Chavan
Introduction To evaluate the safety of percutaneous endovascular aortic repair and the relationship of access site characteristics to complications Materials and Methods All patients undergoing percutaneous TEVAR, EVAR and FEVAR procedures from January 2010 to May 2016 were retrospectively analysed for incidence of complications and their relationship to various access site characteristics like access artery size, degree of vessel calcification, skin to artery distance and sheath to artery ratio. Hemostasis occurring within 15 min after suture closure with or without manual compression was defined as primary hemostasis...
April 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28335058/instructions-for-radiological-case-reports
#3
Peter Bannas
Purpose This paper explains the purpose and structure of a radiological case report and provides guidance for radiologists with respect to the writing of a well-structured patient case report. Materials and Methods The current literature and the author's experience as a writer were used to create a manual that describes steps for preparing a radiological case report containing all of the important ingredients for effective communication. Results Case reports are the first line of evidence in documenting clinical observations in the literature...
April 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28335044/semi-automated-de-identification-of-german-content-sensitive-reports-for-big-data-analytics
#4
Hannes Seuss, Peter Dankerl, Matthias Ihle, Andrea Grandjean, Rebecca Hammon, Nicola Kaestle, Peter A Fasching, Christian Maier, Jan Christoph, Martin Sedlmayr, Alexander Cavallaro, Matthias Hammon
Purpose Projects involving collaborations between different institutions require data security via selective de-identification of words or phrases. A semi-automated de-identification tool was developed and evaluated on different types of medical reports natively and after adapting the algorithm to the text structure. Materials and Methods A semi-automated de-identification tool was developed and evaluated for its sensitivity and specificity in detecting sensitive content in written reports. Data from 4671 pathology reports (4105 + 566 in two different formats), 2804 medical reports, 1008 operation reports, and 6223 radiology reports of 1167 patients suffering from breast cancer were de-identified...
March 23, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28334822/posigene-automated-and-easy-to-use-pipeline-for-genome-wide-detection-of-positively-selected-genes
#5
Arne Sahm, Martin Bens, Matthias Platzer, Karol Szafranski
Many comparative genomics studies aim to find the genetic basis of species-specific phenotypic traits. A prevailing strategy is to search genome-wide for genes that evolved under positive selection based on the non-synonymous to synonymous substitution ratio. However, incongruent results largely due to high false positive rates indicate the need for standardization of quality criteria and software tools. Main challenges are the ortholog and isoform assignment, the high sensitivity of the statistical models to alignment errors and the imperative to parallelize large parts of the software...
March 15, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28334773/a-critical-assessment-of-topologically-associating-domain-prediction-tools
#6
Rola Dali, Mathieu Blanchette
Topologically associating domains (TADs) have been proposed to be the basic unit of chromosome folding and have been shown to play key roles in genome organization and gene regulation. Several different tools are available for TAD prediction, but their properties have never been thoroughly assessed. In this manuscript, we compare the output of seven different TAD prediction tools on two published Hi-C data sets. TAD predictions varied greatly between tools in number, size distribution and other biological properties...
March 2, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28334699/robust-cell-tracking-in-epithelial-tissues-through-identification-of-maximum-common-subgraphs
#7
Jochen Kursawe, Rémi Bardenet, Jeremiah J Zartman, Ruth E Baker, Alexander G Fletcher
Tracking of cells in live-imaging microscopy videos of epithelial sheets is a powerful tool for investigating fundamental processes in embryonic development. Characterizing cell growth, proliferation, intercalation and apoptosis in epithelia helps us to understand how morphogenetic processes such as tissue invagination and extension are locally regulated and controlled. Accurate cell tracking requires correctly resolving cells entering or leaving the field of view between frames, cell neighbour exchanges, cell removals and cell divisions...
November 2016: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28334676/manual-motor-speed-dysfunction-as-a-neurocognitive-endophenotype-in-euthymic-bipolar-disorder-patients-and-their-healthy-relatives-evidence-from-a-5-year-follow-up-study
#8
P Correa-Ghisays, V Balanzá-Martínez, G Selva-Vera, J Vila-Francés, E Soria-Olivas, J Vivas-Lalinde, C San Martín, A M Borrás, R Ayesa-Arriola, J Sanchez-Moreno, J Sánchez-Ort, B Crespo-Facorro, E Vieta, R Tabarés-Seisdedos
BACKGROUND: Few studies have examined Manual Motor Speed (MMS) in bipolar disorder (BD). The aim of this longitudinal, family study was to explore whether dysfunctional MMS represents a neurocognitive endophenotype of BD. METHODS: A sample of 291 subjects, including 131 BD patients, 77 healthy first-degree relatives (BD-Rel), and 83 genetically-unrelated healthy controls (HC), was assessed with the Finger-Tapping Test (FTT) on three occasions over a 5-year period...
March 16, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28334301/dynamix-dynamic-visualization-by-automatic-selection-of-informative-tracks-from-hundreds-of-genomic-data-sets
#9
Matthias Monfort, Eileen E M Furlong, Charles Girardot
Motivation: Visualization of genomic data is fundamental for gaining insights into genome function. Yet, co-visualization of a large number of data sets remains a challenge in all popular genome browsers and the development of new visualization methods is needed to improve the usability and user experience of genome browsers. Results: We present Dynamix, a JBrowse plugin that enables the parallel inspection of hundreds of genomic data sets. Dynamix takes advantage of a priori knowledge to automatically display data tracks with signal within a genomic region of interest...
March 11, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28334059/abutment-disconnection-reconnection-affects-peri-implant-marginal-bone-levels-a-meta-analysis
#10
Theofilos Koutouzis, Fatemeh Gholami, John Reynolds, Tord Lundgren, Georgios A Kotsakis
PURPOSE: Preclinical and clinical studies have shown that marginal bone loss can be secondary to repeated disconnection and reconnection of abutments that affect the peri-implant mucosal seal. The aim of this systematic review and meta-analysis was to evaluate the impact of abutment disconnections/reconnections on peri-implant marginal bone level changes. MATERIALS AND METHODS: To address this question, two reviewers independently performed an electronic search of three major databases up to October 2015 complemented by manual searches...
March 23, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28334010/automated-assessment-of-bone-changes-in-cross-sectional-micro-ct-studies-of-murine-experimental-osteoarthritis
#11
Patricia Das Neves Borges, Tonia L Vincent, Massimo Marenzana
OBJECTIVE: The degradation of articular cartilage, which characterises osteoarthritis (OA), is usually paired with excessive bone remodelling, including subchondral bone sclerosis, cysts, and osteophyte formation. Experimental models of OA are widely used to investigate pathogenesis, yet few validated methodologies for assessing periarticular bone morphology exist and quantitative measurements are limited by manual segmentation of micro-CT scans. The aim of this work was to chart the temporal changes in periarticular bone in murine OA by novel, automated micro-CT methods...
2017: PloS One
https://www.readbyqxmd.com/read/28334002/improving-hybrid-how-to-best-combine-indirect-and-direct-encoding-in-evolutionary-algorithms
#12
Lucas Helms, Jeff Clune
Many challenging engineering problems are regular, meaning solutions to one part of a problem can be reused to solve other parts. Evolutionary algorithms with indirect encoding perform better on regular problems because they reuse genomic information to create regular phenotypes. However, on problems that are mostly regular, but contain some irregularities, which describes most real-world problems, indirect encodings struggle to handle the irregularities, hurting performance. Direct encodings are better at producing irregular phenotypes, but cannot exploit regularity...
2017: PloS One
https://www.readbyqxmd.com/read/28333782/the-normal-adult-human-internal-auditory-canal-a-volumetric-multidetector-computed-tomography-study
#13
Fahad Essbaiheen, Tarek Hegazi, Lorne Rosenbloom
OBJECTIVE: The purpose of this study was to demonstrate that volumetric analysis of multidetector computed tomography (CT) images can be used to calculate the volume of the adult human internal auditory canal (IAC) reproducibly, and to describe the range of normal IAC volumes in the adult population with subgroup analysis of sex, age, and laterality. BACKGROUND: Previous studies of the IAC have typically used measurements in two dimensions or by using casts of cadavers to measure IAC volumes...
March 22, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28333703/higher-fresh-gas-flow-rates-decrease-tidal-volume-during-pressure-control-ventilation
#14
Shazia Mohammad, Nikolaus Gravenstein, Drew Gonsalves, Terrie Vasilopoulos, Samsun Lampotang
BACKGROUND: We observed that increasing fresh gas flow (FGF) decreased exhaled tidal volume (VT) during pressure control ventilation (PCV). A literature search produced no such description whereby unintended VT changes occur with FGF changes during PCV. METHODS: To model an infant's lungs, 1 lung of a mechanical lung model (Dual Adult TTL 1600; Michigan Instruments, Inc, Grand Rapids, MI) was set at a compliance of 0.0068 L/cm H2O. An Rp50 resistor (27.2 cm H2O/L/s at 15 L/min) simulated normal bronchial resistance...
March 22, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28333647/automatic-choroidal-layer-segmentation-using-markov-random-field-and-level-set-method
#15
Chuang Wang, Yongmin Li, Ya Xing Wang
The choroid is an important vascular layer that supplies oxygen and nourishment to the retina. The changes in thickness of the choroid have been hypothesised to relate to a number of retinal diseases in the pathophysiology. In this work, an automatic method is proposed for segmenting the choroidal layer from macular images by using the level set framework. The 3D nonlinear anisotropic diffusion filter is used to remove all the OCT imaging artifacts including the speckle noise and to enhance the contrast. The distance regularisation and edge constraint terms are embedded into the level set method to avoid the irregular and small regions and keep information about the boundary between the choroid and sclera...
March 20, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28333536/mom-net-evaluation-of-an-internet-facilitated-cognitive-behavioral-intervention-for-low-income-depressed-mothers
#16
Lisa B Sheeber, Edward G Feil, John R Seeley, Craig Leve, Jeff M Gau, Betsy Davis, Erik Sorensen, Steve Allan
OBJECTIVE: Evaluate an Internet-facilitated cognitive-behavioral treatment intervention for depression, tailored to economically disadvantaged mothers of young children. METHOD: Economically disadvantaged mothers (N = 266) of preschool aged children, who reported elevated levels of depressive symptoms, were randomized to either the 8-session, Internet-facilitated intervention (Mom-Net) or to Motivational Interviewing and Referral to Services (MIRS). Outcomes were measured using the Patient Health Questionnaire 9 (PHQ-9; Spitzer et al...
April 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/28333479/are-lexical-factors-immune-to-response-modality-in-backward-recall-the-effects-of-imageability-and-word-frequency
#17
Olivia Beaudry, Jean Saint-Aubin, Katherine Guérard, Myriam Pâquet
In immediate serial recall, it is well established that performance is influenced by lexical factors such as imageability and word frequency. However, when participants are asked to recall the to-be-remembered items in their reverse order, known as backward recall, lexical factors produced contradictory findings. In 4 experiments, we tested the role of response modality in modulating the effects of imageability and word frequency in backward recall. The magnitude of the 2 tested lexical factors was only slightly reduced in backward compared with forward recall when participants responded manually...
March 23, 2017: Canadian Journal of Experimental Psychology, Revue Canadienne de Psychologie Expérimentale
https://www.readbyqxmd.com/read/28333407/the-use-of-cellavision%C3%A2-dm96-in-the-verification-of-the-presence-of-blasts-in-samples-flagged-by-the-sysmex-xe-5000
#18
H Eilertsen, C E Henriksson, T-A Hagve
INTRODUCTION: The CellaVision™DM96 is a digital pattern recognition system that classifies white blood cells. The aim of this study was to evaluate whether the CellaVision preclassification feature, without a subsequent re-classification, was a sufficient approach to follow up flags reported by Sysmex XE-5000. METHODS: Pairs of blood smears from 400 samples reported with suspect flags were examined using conventional microscopy and the CellaVision features. The effect of pre- vs...
March 23, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28333189/fully-automated-disc-diffusion-for-rapid-antibiotic-susceptibility-test-results-a-proof-of-principle-study
#19
Michael Hombach, Marion Jetter, Nicolas Blöchliger, Natalia Kolesnik-Goldmann, Erik C Böttger
Background: Antibiotic resistance poses a significant threat to patients suffering from infectious diseases. Early readings of antibiotic susceptibility test (AST) results could be of critical importance to ensure adequate treatment. Disc diffusion is a well-standardized, established and cost-efficient AST procedure; however, its use in the clinical laboratory is hampered by the many manual steps involved, and an incubation time of 16-18 h, which is required to achieve reliable test results...
February 17, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28333030/semen-quality-before-cryopreservation-and-after-thawing-in-543-patients-with-testicular-cancer
#20
Antonio MacKenna, Javier Crosby, Cristián Huidobro, Eduardo Correa, Gonzalo Duque
OBJECTIVE: The main objective of this study was to assess semen characteristics of patients with testicular cancer before cryopreservation and after thawing, to evaluate the consequences of this technique on sperm quality in patients with testicular cancer. METHODS: Five hundred eighty-nine samples from 543 patients with testicular cancer were cryopreserved between 1995 and 2015, one aliquot per patient was used for a thawing test to assess the impact of cryopreservation on sperm motility; semen analysis was performed before cryo preservation and after thawing, the result interpretation was carried out using the 2010 World Health Organization (WHO) Laboratory Manual, and consent forms were signed by the patients for freezing and when sperm was used for reproductive purposes...
February 1, 2017: JBRA Assisted Reproduction
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