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JOURNAL ARTICLE
Paromita Deb, Avisankar Chini, Prarthana Guha, Ashcharya Rishi, Arunoday Bhan, Blake Brady, Linda I Perrotti, Subhrangsu S Mandal
Brain derived neurotrophic factor (BDNF) is a major neurotransmitter that controls growth and maintenance of neurons and its misregulation is linked to neurodegeneration and human diseases. Estradiol (E2) is well-known to regulate the process of differentiation and plasticity of hippocampal neurons. Here we examined the mechanisms of BDNF gene regulation under basal conditions and under stimuli such as E2. Our results demonstrated that BDNF expression is induced by E2 in vitro in HT22 cells (hippocampal neuronal cells) and in vivo (in ovariectomized mouse brain under E2-treatment)...
December 1, 2023: Gene
#22
JOURNAL ARTICLE
Loida M Recopuerto-Medina, Franchesca Chiny U Gutierrez, Jose Antonio S San Diego, Nickhole Andrei E Alviar, Joseff Rayven M Santos, Nikki Heherson A Dagamac
Schistosomiasis is a parasitic infection caused by Schistosoma japonicum. It remains a principal local health issue in the Philippines, demonstrating endemicity in 28 provinces and afflicting thousands of Filipino individuals annually. Despite this, no clear distribution maps for the disease have been comprehensively reported. Therefore, species distribution modeling (SDM) employing the MaxEnt algorithm and GIS application techniques was utilized to denote the potential risk of schistosomiasis in the country...
November 27, 2023: Parasitology International
#23
MULTICENTER STUDY
Anargyros Kapetanakis, Georgios Karakatsoulis, Dimitrios Kyrou, Iliana Ntourou, Nikolaos Vrontaras, Olga Tsachouridou, Maria Meliou, Dimitrios Basoulis, Konstantinos Protopapas, Vasilis Petrakis, Leonidia Leonidou, Ioannis Katsarolis, Simeon Metallidis, Maria Chini, Mina Psichogiou, Anastasia Antoniadou, Periklis Panagopoulos, Charalambos Gogos, Christina Karamanidou
OBJECTIVE: Despite the significant advances in healthcare, people living with HIV still face challenges that affect their quality of life (QoL), both in terms of their physical state as represented by frailty and of their illness perceptions (IP). The aim of this study was to unravel the associations between these constructs (QoL, frailty, IP). METHODS: This multicenter, cross-sectional study included 477 people living with HIV (93% male; median age = 43 years, IQR = 51...
2023: PloS One
#24
JOURNAL ARTICLE
Mohammad Javad Shirshahi, Seyed Farshid Chini, Peyman Taheri, Abraham Mansouri
Cathodic protection as a complementary method is one of the most effective ways to prevent corrosion, along with coating and choosing the suitable material. There are different ways to protect the storage tank bottom. Due to the presence of the geo membrane layer and its effective and pivotal role, the use of mixed metal oxide (MMO) anodes is highly recommended. In the current study, the protection process of the above-ground storage tank bottom is simulated using MMO backfilled wire (concentric rings) and ribbon anodes (mesh grid system)...
November 10, 2023: Scientific Reports
#25
JOURNAL ARTICLE
Tiwana Varrecchia, Alberto Ranavolo, Giorgia Chini, Alessandro Marco De Nunzio, Francesco Draicchio, Eduardo Martinez-Valdes, Deborah Falla, Silvia Conforto
Low back pain (LBP) is a leading cause of disability in the workplace, often caused by manually lifting of heavy loads. Instrumental-based assessment tools are used to quantitatively assess the biomechanical risk of lifting activities. This study aims to verify that, during the execution of fatiguing frequency-dependent lifting, high-density surface electromyography (HDsEMG) allows the discrimination of healthy controls (HC) versus people with LBP and biomechanical risk levels. Fifteen HC and eight people with LBP performed three lifting tasks with a progressively increasing lifting index, each lasting 15 min...
November 4, 2023: Journal of Electromyography and Kinesiology
#26
JOURNAL ARTICLE
Mohamed Irfan Mohamed Refai, Saivimal Sridar, Renee Govaerts, Giorgia Chini, Tiwana Varrecchia, Simona Del Ferraro, Tiziana Falcone, Sander De Bock, Vincenzo Molinaro, Shirley A Elprama, An Jacobs, Alberto Ranavolo, Kevin De Pauw, Herman van der Kooij, Massimo Sartori
Back support soft exosuits are promising solutions to reduce risk of musculoskeletal injuries at workplaces resulting from physically demanding and repetitive lifting tasks. Design of novel active exosuits address the impact on the muscle activity and metabolic costs but do not consider other critical aspects such as comfort and user perception during the intended tasks. Thus, in this study, we describe a novel soft active exosuit in line with its impact on physiological and subjective measures during lifting...
September 2023: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
#27
JOURNAL ARTICLE
Maria Lazzaroni, Giorgia Chini, Francesco Draicchio, Christian Di Natali, Darwin G Caldwell, Jesus Ortiz
Back-support exoskeletons are commonly used in the workplace to reduce low back pain risk for workers performing demanding activities. However, for the assistance of tasks differing from lifting, back-support exoskeletons potential has not been exploited extensively. This work focuses on the use of an active back-support exoskeleton to assist carrying. A control strategy is designed that modulates the exoskeleton torques to comply with the task assistance requirements. In particular, two gait phase detection frameworks are exploited to adapt the exoskeleton assistance according to the legs' motion...
September 2023: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
#28
JOURNAL ARTICLE
Farooq Hassan, Asmat Ullah Khan, Syed Zahoor Ul Hassan Zaidi, Madiha Khan Niazi, Muhammad Amjed Ismail
The aerobic organisms not only need oxygen for survival, but oxygen is also fundamentally malignant to the aerobic organism on the grounds of free radical generation and their affiliation with free oxidative stress. This study was done to evaluate the antioxidant and protective properties of P kurroa , S aromaticum , L inermis , R emodi , and C longa against lipid peroxidation induced by different pro-oxidants. The aqueous extracts of these medicinal plants showed inhibition against thiobarbituric acid reactive species (TBARS) induced by different pro-oxidants (10 mM FeSO4 and 5 mM sodium nitroprusside) in the brain and liver of mice...
2023: Dose-response: a Publication of International Hormesis Society
#29
JOURNAL ARTICLE
Mikel Lavilla-Puerta, Rebecca Latter, Francesca Bellè, Tiziana Cervelli, Alvaro Galli, Pierdomenico Perata, Andrea Chini, Emily Flashman, Beatrice Giuntoli
Hypoxic responses in plants involve Plant Cysteine Oxidases (PCOs). They catalyse the N-terminal cysteine oxidation of Ethylene Response Factors VII (ERF-VII) in an oxygen-dependent manner, leading to their degradation via the cysteine N-degron pathway (Cys-NDP) in normoxia. In hypoxia, PCO activity drops, leading to the stabilization of ERF-VIIs and subsequent hypoxic gene upregulation. Thus far no chemicals have been described to specifically inhibit PCO enzymes. In this work, we devised an in vivo pipeline to discover Cys-NDP effector molecules...
October 18, 2023: Journal of Biological Chemistry
#30
JOURNAL ARTICLE
Lu Yang, Yan Er Ng, Haipeng Sun, Ying Li, Lucas C S Chini, Nathan K LeBrasseur, Jun Chen, Xu Zhang
BACKGROUND: Single-cell RNA-sequencing (scRNA-seq) has become a widely used tool for both basic and translational biomedical research. In scRNA-seq data analysis, cell type annotation is an essential but challenging step. In the past few years, several annotation tools have been developed. These methods require either labeled training/reference datasets, which are not always available, or a list of predefined cell subset markers, which are subject to biases. Thus, a user-friendly and precise annotation tool is still critically needed...
October 20, 2023: BMC Biology
#31
REVIEW
Kamlesh Bisht, Taro Fukao, Marielle Chiron, Paul Richardson, Djordje Atanackovic, Eduardo Chini, Wee Joo Chng, Helgi Van De Velde, Fabio Malavasi
BACKGROUND: CD38 has been established as an important therapeutic target for multiple myeloma (MM), for which two CD38 antibodies are currently approved-daratumumab and isatuximab. CD38 is an ectoenzyme that degrades NAD and its precursors and is involved in the production of adenosine and other metabolites. AIM: Among the various mechanisms by which CD38 antibodies can induce MM cell death is immunomodulation, including multiple pathways for CD38-mediated T-cell activation...
October 15, 2023: Cancer Medicine
#32
JOURNAL ARTICLE
Andrea Cherubini, Benjamin Navarro, Robin Passama, Sonny Tarbouriech, Shirley A Elprama, An Jacobs, Susanne Niehaus, Sascha Wischniewski, Freek J Tönis, Pim L Siahaya, Giorgia Chini, Tiwana Varrecchia, Alberto Ranavolo
Collaborative Robots-CoBots-are emerging as a promising technological aid for workers. To date, most CoBots merely share their workspace or collaborate without contact, with their human partners. We claim that robots would be much more beneficial if they physically collaborated with the worker, on high payload tasks. To move high payloads, while remaining safe, the robot should use two or more lightweight arms. In this work, we address the following question: to what extent can robots help workers in physical human-robot collaboration tasks? To find an answer, we have gathered an interdisciplinary group, spanning from an industrial end user to cognitive ergonomists, and including biomechanicians and roboticists...
2023: PloS One
#33
JOURNAL ARTICLE
Davide Nardi, Diego Fontaneto, Matteo Girardi, Isaac Chini, Daniela Bertoldi, Roberto Larcher, Cristiano Vernesi
Windstorms and salvage logging lead to huge soil disturbance in alpine spruce forests, potentially affecting soil-living arthropods. However, the impacts of forest loss and possible interactions with underlying ecological gradients on soil microarthropod communities remain little known, especially across different environmental conditions. Here we used DNA metabarcoding approach to study wind-induced disturbances on forest communities of springtails and soil mites. In particular, we aimed to test the effect of forest soil disturbance on the abundance, richness, species composition, and functional guilds of microarthropods...
2023: PeerJ
#34
REVIEW
Ashita Jain, Diego Casanova, Alejandra Valdivia Padilla, Angelica Paniagua Bojorges, Sivareddy Kotla, Kyung Ae Ko, Venkata S K Samanthapudi, Khanh Chau, Minh T H Nguyen, Jake Wen, Selina L Hernandez Gonzalez, Shaefali P Rodgers, Elizabeth A Olmsted-Davis, Dale J Hamilton, Cielito Reyes-Gibby, Sai-Ching J Yeung, John P Cooke, Joerg Herrmann, Eduardo N Chini, Xiaolei Xu, Syed Wamique Yusuf, Momoko Yoshimoto, Philip L Lorenzi, Brain Hobbs, Sunil Krishnan, Efstratios Koutroumpakis, Nicolas L Palaskas, Guangyu Wang, Anita Deswal, Steven H Lin, Jun-Ichi Abe, Nhat-Tu Le
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality, especially among the aging population. The "response-to-injury" model proposed by Dr. Russell Ross in 1999 emphasizes inflammation as a critical factor in atherosclerosis development, with atherosclerotic plaques forming due to endothelial cell (EC) injury, followed by myeloid cell adhesion and invasion into the blood vessel walls. Recent evidence indicates that cancer and its treatments can lead to long-term complications, including CVD...
2023: Frontiers in Cardiovascular Medicine
#35
REVIEW
Jiří Masojídek, Richard Lhotský, Karolína Štěrbová, Graziella Chini Zittelli, Giuseppe Torzillo
Microalgae are excellent sources of biomass containing several important compounds for human and animal nutrition-proteins, lipids, polysaccharides, pigments and antioxidants as well as bioactive secondary metabolites. In addition, they have a great biotechnological potential for nutraceuticals, and pharmaceuticals as well as for CO2 sequestration, wastewater treatment, and potentially also biofuel and biopolymer production. In this review, the industrial production of the most frequently used microalgae genera-Arthrospira, Chlorella, Dunaliella, Haematococcus, Nannochloropsis, Phaeodactylum, Porphyridium and several other species is discussed as concerns the applicability of the most widely used large-scale systems, solar bioreactors (SBRs)-open ponds, raceways, cascades, sleeves, columns, flat panels, tubular systems and others...
September 19, 2023: Applied Microbiology and Biotechnology
#36
JOURNAL ARTICLE
Simona De Vita, Sara Meninno, Lucia Capasso, Ester Colarusso, Maria Giovanna Chini, Gianluigi Lauro, Romolo Rinaldi, Annalisa De Cicco, Veronica Sian, Stefania Terracciano, Angela Nebbioso, Alessandra Lattanzi, Giuseppe Bifulco
Herein, we report the development of a new series of histone deacetylase inhibitors (HDACi) containing a 2-substituted 1,5-benzothiazepine scaffold. First, a virtual combinatorial library (∼1.6 × 103 items) was built according to a convenient synthetic route, and then it was submitted to molecular docking experiments on seven HDACs isoforms belonging to classes I and II. Integrated computational filters were used to select the most promising ones that were synthesized through an optimized approach, also amenable to generating both racemic and enantioenriched benzothiazepine-based derivatives...
August 12, 2023: Bioorganic & Medicinal Chemistry
#37
REVIEW
Vasiliki Nikovia, Evangelos Chinis, Areti Gkantaifi, Maria Marketou, Michalis Mazonakis, Nikolaos Charalampakis, Dimitrios Mavroudis, Kornilia Vasiliki Orfanidou, Antonios Varveris, Chrysostomos Antoniadis, Maria Tolia
BACKGROUND: Breast cancer (BC) is the most common malignancy in females, accounting for the majority of cancer-related deaths worldwide. There is well-established understanding about the effective role of radiotherapy (RT) in BC therapeutic strategies, offering a better local-regional control, prolonged survival, and improved quality of life for patients. However, it has been proven that conventional RT modalities, especially in left-sided BC cases, are unable to avoid the administration of high RT doses to the heart, thus resulting in cardiotoxicity and promoting long-term cardiovascular diseases (CVD)...
June 24, 2023: Journal of Personalized Medicine
#38
REVIEW
Angela Rizzi, Mario Di Gioacchino, Luca Gammeri, Riccardo Inchingolo, Raffaella Chini, Francesca Santilli, Eleonora Nucera, Sebastiano Gangemi
Celiac disease (CD) is an intestinal disease that develops in genetically predisposed individuals and is triggered by the ingestion of gluten. CD was considered a Th1-disease. Today, the role of Th17, IL-21, and IL-17A lymphocytes is well known. Inflammation is regulated by the activity of gluten-specific CD4+ T lymphocytes that produce pro-inflammatory cytokines, including IFN-γ, TNF-α, and IL-21, perpetuating the Th1 response. These cytokines determine an inflammatory state of the small intestine, with consequent epithelial infiltration of lymphocytes and an alteration of the architecture of the duodenal mucosa...
July 21, 2023: Cells
#39
Carlos Escande, Karina Cal, Alejandro Leyva, Jorge Rodriguez-Duarte, Santiago Ruiz, Leonardo Santos, Lucía Colella, Mariana Ingold, Cecilia Vilaseca, German Galliussi, Lucía Ziegler, Thais Peclat, Mariana Bresque, Rachel Handy, Rachel King, Larisa Menezes Dos Reis, Camila Espasandin, Peter Breining, Rosina Dapueto, Andres Lopez, Katie Thompson, Guillermo Agorrody, Evan DeVallance, Ethan Meadows, Sara Lewis, Gabriele Santana Barbosa, Leonardo Osbourne Lai de Souza, Marina Santos Chichierchio, Valeria Valez, Adrian Aicardo, Paola Contreras, Mikkel Vendelbo, Steen Jakobsen, Andres Kamaid, Williams Porcal, Aldo Calliari, Jose Verdes, Jianhai Du, Yekai Wang, John Hollander, Thomas White, Rafael Radi, Guillermo Moyna, Celia Quijano, Robert O'Doherty, Pedro Manoel Moraes-Vieira, Graham Holloway, Roberta Leonardi, Marcelo Mori, Juliana Camacho-Pereira, Eric Kelley, Rosario Duran, Gloria Lopez, Carlos Batthyany, Eduardo Chini
Obesity-related type II diabetes (diabesity) has increased global morbidity and mortality dramatically. Previously, the ancient drug salicylate demonstrated promise for the treatment of type II diabetes, but its clinical use was precluded due to high dose requirements. In this study, we present a nitroalkene derivative of salicylate, 5-(2-nitroethenyl)salicylic acid (SANA), a molecule with unprecedented beneficial effects in diet-induced obesity (DIO). SANA reduces DIO, liver steatosis and insulin resistance at doses up to 40 times lower than salicylate...
July 12, 2023: Research Square
#40
JOURNAL ARTICLE
Valentina Parisi, Giuliana Donadio, Maria Laura Bellone, Soumia Belaabed, Ammar Bader, Angela Bisio, Valeria Iobbi, Erica Gazzillo, Maria Giovanna Chini, Giuseppe Bifulco, Immacolata Faraone, Antonio Vassallo
Premna , a genus consisting of approximately 200 species, predominantly thrives in tropical and subtropical areas. Many of these species have been utilized in ethnopharmacology for diverse medicinal applications. In Saudi Arabia, Premna resinosa (Hochst.) Schauer (Lamiaceae) grows wildly, and its slightly viscid leaves are attributed to the production of leaf accession. In this study, we aimed to extract the surface accession from fresh leaves using dichloromethane to evaluate the anticancer potential. The plant exudate yielded two previously unknown labdane diterpenes, Premnaresone A and B, in addition to three already described congeners and four known flavonoids...
June 22, 2023: Plants (Basel, Switzerland)
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