keyword
https://read.qxmd.com/read/38537155/giredestrant-for-estrogen-receptor-positive-her2-negative-previously-treated-advanced-breast-cancer-results-from-the-randomized-phase-ii-acelera-breast-cancer-study
#1
JOURNAL ARTICLE
Miguel Martín, Elgene Lim, Mariana Chavez-MacGregor, Aditya Bardia, Jiong Wu, Qingyuan Zhang, Zbigniew Nowecki, Felipe Melo Cruz, Rustem Safin, Sung-Bae Kim, Christian Schem, Alberto J Montero, Sarah Khan, Reeti Bandyopadhyay, Heather M Moore, Mahesh Shivhare, Monika Patre, Jorge Martinalbo, Laura Roncoroni, Pablo Diego Pérez-Moreno, Joohyuk Sohn
PURPOSE: To compare giredestrant and physician's choice of endocrine monotherapy (PCET) for estrogen receptor-positive, HER2-negative, advanced breast cancer (BC) in the phase II acelERA BC study (ClinicalTrials.gov identifier: NCT04576455). METHODS: Post-/pre-/perimenopausal women, or men, age 18 years or older with measurable disease/evaluable bone lesions, whose disease progressed after 1-2 lines of systemic therapy (≤1 targeted, ≤1 chemotherapy regimen, prior fulvestrant allowed) were randomly assigned 1:1 to giredestrant (30 mg oral once daily) or fulvestrant/aromatase inhibitor per local guidelines (+luteinizing hormone-releasing hormone agonist in pre-/perimenopausal women, and men) until disease progression/unacceptable toxicity...
March 27, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38536615/quantification-of-unencapsulated-drug-in-target-tissues-demonstrates-pharmacological-properties-and-therapeutic-effects-of-liposomal-topotecan-ff-10850
#2
JOURNAL ARTICLE
Toshifumi Kimura, Ken Okada, Yasushi Morohashi, Yukio Kato, Mikinaga Mori, Hiroshi Kato, Takeshi Matsumoto, Susumu Shimoyama
PURPOSE: Quantifying unencapsulated drug concentrations in tissues is crucial for understanding the mechanisms underlying the efficacy and safety of liposomal drugs; however, the methodology for this has not been fully established. Herein, we aimed to investigate the enhanced therapeutic potential of a pegylated liposomal formulation of topotecan (FF-10850) by analyzing the concentrations of the unencapsulated drug in target tissues, to guide the improvement of its dosing regimen. METHODS: We developed a method for measuring unencapsulated topotecan concentrations in tumor and bone marrow interstitial fluid (BM-ISF) and applied this method to pharmacokinetic assessments...
March 27, 2024: Pharmaceutical Research
https://read.qxmd.com/read/38536511/repeatability-of-18-f-fdg-uptake-in-metastatic-bone-lesions-of-breast-cancer-patients-and-implications-for-accrual-to-clinical-trials
#3
JOURNAL ARTICLE
Mark Muzi, Lanell M Peterson, Jennifer M Specht, Daniel S Hippe, Alena Novakova-Jiresova, Jean H Lee, Brenda F Kurland, David A Mankoff, Nancy Obuchowski, Hannah M Linden, Paul E Kinahan
BACKGROUND: Standard measures of response such as Response Evaluation Criteria in Solid Tumors are ineffective for bone lesions, often making breast cancer patients that have bone-dominant metastases ineligible for clinical trials with potentially helpful therapies. In this study we prospectively evaluated the test-retest uptake variability of 2-deoxy-2-[18F]fluoro-D-glucose (18 F-FDG) in a cohort of breast cancer patients with bone-dominant metastases to determine response criteria. The thresholds for 95% specificity of change versus no-change were then applied to a second cohort of breast cancer patients with bone-dominant metastases...
March 27, 2024: EJNMMI Research
https://read.qxmd.com/read/38535772/musculoskeletal-pitfalls-on-molecular-imaging-studies-of-oncologic-patients-how-to-stay-out-of-trouble
#4
REVIEW
Brooke Sarna, Ty Subhawong, Efrosyni Sfakianaki, Richard Wang, Anna Christodoulou-Vega, Fabiano N Cardoso
An increasing amount of molecular imaging studies are ordered each year for an oncologic population that continues to expand and increase in age. The importance of these studies in dictating further care for oncologic patients underscores the necessity of differentiating benign from malignant findings, particularly for a population in whom incidental findings are common. The aim of this review is to provide pictorial examples of benign musculoskeletal pathologies which may be found on molecular imaging and which may be mistaken for malignant processes...
March 8, 2024: Tomography: a Journal for Imaging Research
https://read.qxmd.com/read/38535766/dual-energy-ct-in-oncologic-imaging
#5
REVIEW
Giovanni Foti, Giorgio Ascenti, Andrea Agostini, Chiara Longo, Fabio Lombardo, Alessandro Inno, Alessandra Modena, Stefania Gori
Dual-energy CT (DECT) is an innovative technology that is increasingly widespread in clinical practice. DECT allows for tissue characterization beyond that of conventional CT as imaging is performed using different energy spectra that can help differentiate tissues based on their specific attenuation properties at different X-ray energies. The most employed post-processing applications of DECT include virtual monoenergetic images (VMIs), iodine density maps, virtual non-contrast images (VNC), and virtual non-calcium (VNCa) for bone marrow edema (BME) detection...
February 23, 2024: Tomography: a Journal for Imaging Research
https://read.qxmd.com/read/38535060/nodal-low-grade-b-cell-lymphoma-co-expressing-cd5-and-cd10-but-not-cd23-irta1-or-cyclin-d1-the-diagnostic-challenge-of-a-splenic-marginal-zone-lymphoma
#6
JOURNAL ARTICLE
Khin-Than Win, Yen-Chuan Hsieh, Hung-Chang Wu, Shih-Sung Chuang
The diagnosis of lymphoma is based on histopathological and immunophenotypical features. CD5 and CD10 are traditionally considered a T-cell antigen and a germinal center B-cell antigen, respectively. It is very unusual for a low-grade B-cell lymphoma (BCL) to co-express CD5 and CD10. Although the biologic basis or clinical significance of such co-expression is unclear, this rare event may pose a significant diagnostic challenge. Here, we report a case of a 63-year-old male presenting with bilateral cervical lymphadenopathy and lymphocytosis...
March 18, 2024: Diagnostics
https://read.qxmd.com/read/38534881/primary-bone-lymphoma-of-the-scapula
#7
Josip Lovaković, Inga Mandac Smoljanović, Andro Matković, Tomislav Smoljanović
Primary bone lymphoma of the scapula is a rare tumor that usually causes local pain. The presented patient suffered for two years from paresthesia, tingling, numbness, and edema of the little and ring fingers. The 45-year-old man underwent several radiological and neurological assessments of the palm, elbow, and neck before radiographs revealed a tumor of the left shoulder. Once diffuse large B-cell lymphoma was confirmed, immunochemotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine, and methylprednisolone (R-CHOP) started...
February 28, 2024: Hematology Reports
https://read.qxmd.com/read/38534360/the-roles-of-fibrinolytic-factors-in-bone-destruction-caused-by-inflammation
#8
REVIEW
Yosuke Kanno
Chronic inflammatory diseases, such as rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, Crohn's disease, periodontitis, and carcinoma metastasis frequently result in bone destruction. Pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, and IL-17 are known to influence bone loss by promoting the differentiation and activation of osteoclasts. Fibrinolytic factors, such as plasminogen (Plg), plasmin, urokinase-type plasminogen activator (uPA), its receptor (uPAR), tissue-type plasminogen activator (tPA), α2-antiplasmin (α2AP), and plasminogen activator inhibitor-1 (PAI-1) are expressed in osteoclasts and osteoblasts and are considered essential in maintaining bone homeostasis by regulating the functions of both osteoclasts and osteoblasts...
March 15, 2024: Cells
https://read.qxmd.com/read/38534214/anti-cd99-antibody-therapy-triggers-macrophage-dependent-ewing-cell-death-in-vitro-and-myeloid-cell-recruitment-in-vivo
#9
JOURNAL ARTICLE
Allison F O'Neill, Evelyn M Nguyen, Evelyn D Maldonado, Matthew R Chang, Jiusong Sun, Quan Zhu, Wayne A Marasco
BACKGROUND: Ewing sarcoma is a rare tumor of the bone or soft tissues characterized by diffuse membranous staining for CD99. As this tumor remains incurable in the metastatic, relapsed, and refractory settings, we explored the downstream immune implications of targeting CD99. METHODS: We discovered a human anti-CD99 antibody (NOA2) by phagemid panning and investigated NOA2 immune cell-mediated cytotoxicity in vitro and in vivo focusing on the myeloid cell compartment, given that M2 macrophages are present in human tumors and associated with a poor prognosis...
March 18, 2024: Antibodies
https://read.qxmd.com/read/38534161/surgical-management-of-complex-skull-base-tumor-using-preoperative-multimodal-image-fusion-technology
#10
JOURNAL ARTICLE
Zhi-Heng Jian, Peng Chen, Yu Li, Chang-Chun Liao, Xin-Feng Yi, Run-Gen Zhan, Gang Chen
OBJECTIVE: To review our single-institution experience in the surgical management of complex skull base tumors using multimodal image fusion technology. METHODS: From October 2019 to January 2022, 7 cases of complex skull base tumors that performed preoperative multimodal image fusion in Zhuhai People's Hospital neurosurgery department were involved in this study. The image data were uploaded to the GE AW workstation. Corresponding image sequences were opened in the workstation to complete registration fusion and 3D reconstruction...
March 27, 2024: Journal of Craniofacial Surgery
https://read.qxmd.com/read/38533914/recycled-bone-grafts-treated-with-extracorporeal-irradiation-or-liquid-nitrogen-freezing-after-malignant-tumor-resection
#11
JOURNAL ARTICLE
Yuta Takeuchi, Akio Sakamoto, Takashi Noguchi, Junya Toguchida, Shuichi Matsuda
INTRODUCTION: Recycled bone autografts prepared using extracorporeal irradiation (ECIR) or liquid nitrogen freezing (LNF) methods have been used for the reconstruction of skeletal elements after wide resection of sarcomas involving bone tissues. Few reports include long-term follow-up data for histological analyses of recycled autografts, particularly in the case of ECIR autografts. MATERIALS: A total of 34 malignant bone and soft tissue tumors were resected and reconstructed using 11 ECIR- and 23 LNF-recycled autografts; the mean postoperative follow-ups were 14 and 8 years, respectively...
March 27, 2024: Journal of Surgical Oncology
https://read.qxmd.com/read/38532928/intelligent-structure-prediction-and-visualization-analysis-of-non-coding-rna-in-osteosarcoma-research
#12
Longhao Chen, Liuji He, Baijie Liu, Yinghua Zhou, Lijiang Lv, Zhiguang Wang
BACKGROUND: Osteosarcoma (OS) is the most common bone malignant tumor in children and adolescents. Recent research indicates that non-coding RNAs (ncRNAs) have been associated with OS occurrence and development, with significant progress made in this field. However, there is no intelligent structure prediction and literature visualization analysis in this research field. From the perspective of intelligent knowledge structure construction and bibliometrics, this study will comprehensively review the role of countries, institutions, journals, authors, literature citation relationships and subject keywords in the field of ncRNAs in OS...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38532893/bms-794833-reduces-anlotinib-resistance-in-osteosarcoma-by-targeting-the-vegfr-ras-cdk2-pathway
#13
JOURNAL ARTICLE
Qingtao Meng, Jian Han, Peng Wang, Chenxu Jia, Mingyang Guan, Bolun Zhang, Wenzhi Zhao
BACKGROUND: Osteosarcoma, a tumor that originates from bone cells, has a poor prognosis and a high degree of malignancy. Anlotinib, a small-molecule multi-target tyrosine kinase inhibitor (TKI), is the first-line drug in treating osteosarcoma, especially in late-stage osteosarcoma. However, patients often develop resistance after using anlotinib for a certain period, which poses a challenge to its further clinical application. Recently, several TKIs, for instance regorafenib and cabozantinib, have showed clinical interest in treating osteosarcoma and target both vascular endothelial growth factor receptor (VEGFR) and mesenchymal epithelial transition factor (c-MET)...
April 2024: Journal of Bone Oncology
https://read.qxmd.com/read/38532886/the-rna-binding-proteins-larp4a-and-larp4b-promote-sarcoma-and-carcinoma-growth-and-metastasis
#14
JOURNAL ARTICLE
Jennifer C Coleman, Luke Tattersall, Val Yianni, Laura Knight, Hongqiang Yu, Sadie R Hallett, Philip Johnson, Ana J Caetano, Charlie Cosstick, Anne J Ridley, Alison Gartland, Maria R Conte, Agamemnon E Grigoriadis
RNA-binding proteins (RBPs) are emerging as important regulators of cancer pathogenesis. We reveal that the RBPs LARP4A and LARP4B are differentially overexpressed in osteosarcoma and osteosarcoma lung metastases, as well as in prostate cancer. Depletion of LARP4A and LARP4B reduced tumor growth and metastatic spread in xenografts, as well as inhibiting cell proliferation, motility, and migration. Transcriptomic profiling and high-content multiparametric analyses unveiled a central role for LARP4B, but not LARP4A, in regulating cell cycle progression in osteosarcoma and prostate cancer cells, potentially through modulating key cell cycle proteins such as Cyclins B1 and E2, Aurora B, and E2F1...
April 19, 2024: IScience
https://read.qxmd.com/read/38532872/giant-cell-tumor-of-bone-a-multicenter-epidemiological-study-in-brazil
#15
JOURNAL ARTICLE
Ricardo Gehrke Becker, Carlos Roberto Galia, Julie Francine Cerutti Santos Pestilho, Bruno Pereira Antunes, André Mathias Baptista, Alex Guedes
INTRODUCTION: Giant cell tumor of bone (GCTB) mainly affects young adults' long bone epiphyses, threatening bone strength and joint function. Surgery is the primary treatment, although post-surgery recurrence is significant. This study analyzes patient profiles, treatments, and outcomes for GCTB in Brazil. METHODS: We retrospectively assessed local recurrence, metastasis, and treatment approaches in 643 GCTB patients across 16 Brazilian centers (1989-2021), considering regional differences...
2024: Acta Ortopedica Brasileira
https://read.qxmd.com/read/38532255/ewing-sarcoma-chest-wall-reconstruction-following-resection-of-rare-primary-chest-wall-tumor
#16
JOURNAL ARTICLE
Ilya Sakharuk, Thomas McKinley, Gabrielle Moore, Daniel Miller
Ewing sarcoma (ES) represents the second most common primary osseous malignancy in children and young adults, most often occurring in the diaphysis of the long bones. While rare, ES can present as an osseous tumor of the ribs and/or chest wall. These tumors are known as Askin's tumors and most commonly present with symptoms resembling pneumonia. We report the case of a 26-year-old man who was found to have a right lung mass extending into his anterolateral chest wall after presenting to the hospital for evaluation of unremitting chest pain...
March 26, 2024: American Surgeon
https://read.qxmd.com/read/38531846/usp3-promotes-osteosarcoma-progression-via-deubiquitinating-epha2-and-activating-the-pi3k-akt-signaling-pathway
#17
JOURNAL ARTICLE
Anan Li, Shijiang Wang, Jiangbo Nie, Shining Xiao, Xinsheng Xie, Yu Zhang, Weilai Tong, Geliang Yao, Ning Liu, Fan Dan, Zhiguo Shu, Jiaming Liu, Zhili Liu, Feng Yang
Ubiquitin-specific protease 3 (USP3) plays an important role in the progression of various tumors. However, the role of USP3 in osteosarcoma (OS) remains poorly understood. The aim of this study was to explore the biological function of USP3 in OS and the underlying molecular mechanism. We found that OS had higher USP3 expression compared with that of normal bone tissue, and high expression of USP3 was associated with poor prognosis in patients with OS. Overexpression of USP3 significantly increased OS cell proliferation, migration, and invasion...
March 26, 2024: Cell Death & Disease
https://read.qxmd.com/read/38530974/conductive-and-enhanced-mechanical-strength-of-mo-2-ti-2-c-3-mxene-based-hydrogel-promotes-neurogenesis-and-bone-regeneration-in-bone-defect-repair
#18
JOURNAL ARTICLE
Hongyu Wang, Yu-Ching Hsu, Chune Wang, Xiao Xiao, Zhengbin Yuan, Yong Zhu, Dazhi Yang
Bone defects are common with increasing high-energy fractures, tumor bone invasion, and implantation revision surgery. Bone is an electroactive tissue that has electromechanical interaction with collogen, osteoblasts, and osteoclasts. Hydrogel provides morphological plasticity and extracellular matrix (ECM) 3D structures for cell survival, and is widely used as a bone engineering material. However, the hydrogels have poor mechanical intensity and lack of cell adhesion, slow gelation time, and limited conductivity...
March 26, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38530432/chemotherapy-initiated-cysteine-rich-protein-61-decreases-acute-b-lymphoblastic-leukemia-chemosensitivity
#19
JOURNAL ARTICLE
Pengchong Shi, Zhen Lin, Yanfang Song, Zhaozhong Li, Menglu Zeng, Li Luo, Yingping Cao, Xianjin Zhu
PURPOSE: Chemoresistance is a major challenge for acute lymphoblastic leukemia (ALL) treatment. Cysteine-rich protein 61 (Cyr61) plays an important role in drug resistance modulation of tumor cells, and Cyr61 levels are increased in the bone marrow of patients with ALL and contribute to ALL cell survival. However, the effect of Cyr61 on B cell acute lymphoblastic leukemia (B-ALL) cell chemosensitivity and the regulatory mechanisms underlying Cyr61 production in bone marrow remain unknown...
March 26, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38529460/vitamin-d-deficiency-in-pediatric-oncology-patients-a-single-center-experience-in-saudi-arabia
#20
JOURNAL ARTICLE
Dania A Monagel, Amal O Albaity, Fatimah M Asiri, Lama N Alghamdi, Raghad A Alsufyani, Reem B Alqarni, Shaden K Bahatheq, Omaima Ahmed, Naglla Elimam, Alaa Althubaiti
Background There is a lack of local studies on vitamin D deficiency in children with cancer. This study aims to estimate the prevalence of vitamin D deficiency in the pediatric oncology population at King Abdul-Aziz Medical City (KAMC) in Jeddah, addressing knowledge gaps for improved clinical practice and future research. Methods This retrospective observational study was conducted from 2016 to 2021 at the pediatric oncology clinic in National Guard Hospital, Jeddah. The study focused on children aged 14 or younger at cancer diagnosis, data encompassed patient demographics, cancer details, and treatment information, including serum measurements of vitamin D (25(OH)D, calcium, phosphate, alkaline phosphatase)...
February 2024: Curēus
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