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high reliability organization

J R Bowers, K L Parise, E J Kelley, D Lemmer, J M Schupp, E M Driebe, D M Engelthaler, P Keim, B M Barker
Coccidioides immitis and Coccidioides posadasii are soil fungi endemic to desert regions of the southwestern United States, and the causative agents of valley fever, or coccidioidomycosis. Studies have shown that the distribution of Coccidioides in soils is sporadic and cannot be explained by soil characteristics alone, suggesting that biotic and other abiotic factors should be examined. However, tools to reliably and robustly screen the large number of soils needed to investigate these potential associations have not been available...
March 8, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
Hemant Gujar, Jane W Liang, Nicholas C Wong, Khyobeni Mozhui
The Illumina Infinium MethylationEPIC provides an efficient platform for profiling DNA methylation in humans at over 850,000 CpGs. Model organisms such as mice do not currently benefit from an equivalent array. Here we used this array to measure DNA methylation in mice. We defined probes targeting conserved regions and performed differential methylation analysis and compared between the array-based assay and affinity-based DNA sequencing of methyl-CpGs (MBD-seq) and reduced representation bisulfite sequencing...
2018: PloS One
Masanori Ando, Vasudevanpillai Biju, Yasushi Shigeri
Ozone (O3 ) gas is widely used as a strong oxidizing agent for many purposes, such as the decomposition/removal of organic contaminants and photoresist, and the deodorization/disinfection of air and water. However, ozone is highly toxic to the human body when the air concentration exceeds about 1 ppm. Therefore, there is increasing demand for simple, sensitive, reliable, and cost-effective techniques for sensing ozone gas. This article describes the features, advantages, and disadvantages of the available, practical techniques for sensing ozone gas in ambient air...
2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
María Jesús Martínez Bueno, Francisco José Díaz-Galiano, Łukasz Rajski, Víctor Cutillas, Amadeo R Fernández-Alba
In the last decade, the consumption trend of organic food has increased dramatically worldwide. However, the lack of reliable chemical markers to discriminate between organic and conventional products makes this market susceptible to food fraud in products labeled as "organic". Metabolomic fingerprinting approach has been demonstrated as the best option for a full characterization of metabolome occurring in plants, since their pattern may reflect the impact of both endogenous and exogenous factors...
March 3, 2018: Journal of Chromatography. A
Yvonne Stallard
PURPOSE: The purpose of this Evidence-Based Report Card was to examine current best evidence related to when and how to perform cultures on chronic wounds to guide clinicians in determining the appropriate treatment. QUESTION: (1) When should cultures be performed on chronic wounds? and (2) What is the best method or technique to perform a culture on a chronic wound? SEARCH STRATEGY: A search of the literature was performed, resulting in 45 publications relevant to the topic...
March 2018: Journal of Wound, Ostomy, and Continence Nursing
François-Xavier Ferracci, Hugues Duffau
Radical glioma resection improves overall survival, both in low-grade and high-grade glial tumors. However, preservation of the quality of life is also crucial. Areas covered: Due to the diffuse feature of gliomas, which invade the central nervous system, and due to considerable variations of brain organization among patients, an individual cerebral mapping is mandatory to solve the classical dilemma between the oncological and functional issues. Because functional neuroimaging is not reliable enough, intraoperative electrical stimulation, especially in awake patients benefiting from a real-time cognitive monitoring, is the best way to increase the extent of resection while sparing eloquent neural networks...
March 9, 2018: Expert Review of Neurotherapeutics
Jens Leifeld
Nitrous oxide (N2 O) contributes substantially to greenhouse gas (GHG) emissions in the agricultural and land-use sectors. Owing to the high effort needed for measuring N2 O emissions and the resulting lack of sufficient field measurements to apply at country-wide scale, soil-borne N2 O emissions are often estimated by applying published IPCC default emission factors. To examine the data reported in the national GHG inventory, the current study utilizes a large data set of soil C/N ratios to predict N2 O emissions and their distribution from drained organic soils in Switzerland...
March 5, 2018: Science of the Total Environment
Amer Jamalpoor, Rolf W Sparidans, Carla Pou Casellas, Johannes J M Rood, Mansi Joshi, Rosalinde Masereeuw, Manoe J Janssen
Nephropathic cystinosis is characterized by abnormal intralysosomal accumulation of cystine throughout the body causing irreversible damage to various organs, particularly the kidneys. Cysteamine, the currently available treatment, can reduce lysosomal cystine and postpone disease progression. However, cysteamine poses serious side effects and does not address all symptoms of cystinosis. To screen for new treatment options, a rapid and reliable high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was developed to quantify cystine in conditionally immortalized human proximal tubular epithelial cells (ciPTEC)...
March 8, 2018: Biomedical Chromatography: BMC
Wolfgang Schwack, Elodie Pellissier, Gertrud Morlock
Food authenticity and food safety are of high importance to organizations as well as to the food industry to ensure an accurate labeling of food products. Respective analytical methods should provide a fast screening and a reliable cost-efficient quantitation. HPTLC was pointed out as key analytical technique in this field. A new HPTLC method applying caffeine-impregnated silica gel plates was developed for eight most frequently found fat-soluble azo dyes unauthorizedly added to spices, spice mixtures, pastes, sauces, and palm oils...
March 7, 2018: Analytical and Bioanalytical Chemistry
Yijia Zhang, Hongfei Lin, Zhihao Yang, Jian Wang, Yiwei Liu
BACKGROUND: Recently, researchers have tried to integrate various dynamic information with static protein-protein interaction (PPI) networks to construct dynamic PPI networks. The shift from static PPI networks to dynamic PPI networks is essential to reveal the cellular function and organization. However, it is still impossible to construct an absolutely reliable dynamic PPI networks due to the noise and incompletion of high-throughput experimental data. RESULTS: To deal with uncertain data, some uncertain graph models and theories have been proposed to analyze social networks, electrical networks and biological networks...
October 16, 2017: BMC Genomics
Lavinia P Middleton, Ron Phipps, Mark Routbort, Victor Prieto, L Jeffrey Medeiros, Michael Riben, Alejandro Contreras, James Kelley, Keyur Patel, John Bingham, Elizabeth A Wagar
Many high-reliability organizations in industries outside of health care have sustained high levels of excellence and prevention of harm while managing complex systems and risk. To date, no health care organizations has organized its efforts to achieve highly reliable results despite several decades of improvement science. Laboratorians were early adopters of quality initiatives and process improvements. In the late 1990s, the Division of Pathology and Laboratory Medicine at The University of Texas MD Anderson Cancer Center embarked on a major effort to improve quality and patient safety and to reduce waste...
February 1, 2018: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
Qing Zhao, Weiwei Huang, Zhiqiang Luo, Luojia Liu, Yong Lu, Yixin Li, Lin Li, Jinyan Hu, Hua Ma, Jun Chen
Quinones, which are ubiquitous in nature, can act as sustainable and green electrode materials but face dissolution in organic electrolytes, resulting in fast fading of capacity and short cycle life. We report that quinone electrodes, especially calix[4]quinone (C4Q) in rechargeable metal zinc batteries coupled with a cation-selective membrane using an aqueous electrolyte, exhibit a high capacity of 335 mA h g-1 with an energy efficiency of 93% at 20 mA g-1 and a long life of 1000 cycles with a capacity retention of 87% at 500 mA g-1 ...
March 2018: Science Advances
Hongmin Jia, Shuhe Xia, Huan Feng, Qingtao Meng, Chengchen Duan, Zhiqiang Zhang, Run Zhang
Quantitative detection and visualization of hypochlorous acid (HOCl) in biological samples has emerged as a hot topic in biochemical research because of the important role of this biomolecule in live organisms. In this contribution, a novel 1,8-naphthalimide-based fluorescence probe, DNPH-NA, was designed and synthesized for HOCl detection in aqueous solutions and in biological systems. In the presence of HOCl, significant changes in absorption and fluorescence spectra were observed, which allow for the quantitative detection of HOCl in PBS buffer...
March 6, 2018: Organic & Biomolecular Chemistry
Peter J Pronovost, C Michael Armstrong, Renee Demski, Ronald R Peterson, Paul B Rothman
Purpose The purpose of this paper is to offer six principles that health system leaders can apply to establish a governance and management system for the quality of care and patient safety. Design/methodology/approach Leaders of a large academic health system set a goal of high reliability and formed a quality board committee in 2011 to oversee quality and patient safety everywhere care was delivered. Leaders of the health system and every entity, including inpatient hospitals, home care companies, and ambulatory services staff the committee...
March 19, 2018: Journal of Health Organization and Management
Ana Barros, Luís Moreira, Helena Santos, Nuno Ribeiro, Filipe Santos-Silva
Cancer literacy is currently one of the most important dimensions of cancer continuum. Objective assessment of cancer knowledge in populations remains a challenging field to public health entities. Different evaluation tools are currently available; still, some groups remain disregarded due to the absence of validated instruments. Cancer literacy in adolescents and young adults has been clearly overlooked being a subject that requires new tools to be properly studied. To address this topic, we developed a new instrument and field tested it in a classroom environment for internal reliability, construct, and face validity...
March 5, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
Derya Dokur, Seda Keskin
Metal-organic frameworks (MOFs) have been considered as highly promising materials for adsorption-based CO2 separations. The number of synthesized MOFs has been increasing very rapidly. High-throughput molecular simulations are very useful to screen large numbers of MOFs in order to identify the most promising adsorbents prior to extensive experimental studies. Results of molecular simulations depend on the force field used to define the interactions between gas molecules and MOFs. Choosing the appropriate force field for MOFs is essential to make reliable predictions about the materials' performance...
February 14, 2018: Industrial & Engineering Chemistry Research
Krista Freimann, Piret Arukuusk, Kaido Kurrikoff, Ly Pärnaste, Raivo Raid, Andres Piirsoo, Margus Pooga, Ülo Langel
Although advances in genomics and experimental gene therapy have opened new possibilities for treating otherwise incurable diseases, the transduction of nucleic acids into the cells and delivery in vivo remain challenging. The high molecular weight and anionic nature of nucleic acids require their packing into nanoparticles for the delivery. The efficacy of nanoparticle drugs necessitates the high bioactivity of constituents, but their distribution in organisms is mostly governed by the physical properties of nanoparticles, and therefore, generation of stable particles with strictly defined characteristics is highly essential...
March 2, 2018: Molecular Therapy. Nucleic Acids
Heidi L McNeely, Karen K Thomason, Suhong Tong
PURPOSE: Compare two pediatric fall risk assessment tools (I'M SAFE and Humpty Dumpty) used at the same organization to determine if one is better able to predict which patients fall. DESIGN AND METHODS: Retrospective data was obtained from patients admitted in 2014. Each patient who experienced a fall during hospitalization was matched with two non-fallers based on age and diagnosis. Logistic regression was performed to identify which tool more accurately determines fall risk and reliability testing was completed for the I'M SAFE tool...
February 27, 2018: Journal of Pediatric Nursing
Saravanan Esakki, Joy C MacDermid, Joshua I Vincent, Tara L Packham, David Walton, Ruby Grewal
Background: The Patient-Rated Wrist Evaluation (PRWE) was developed as a wrist joint specific measure of pain and disability and evidence of sound validity has been accumulated through classical psychometric methods. Rasch analysis (RA) has been endorsed as a newer method for analyzing the clinical measurement properties of self-report outcome measures. The purpose of this study was to evaluate the PRWE using Rasch modeling. Methods: We employed the Rasch model to assess overall fit, response scaling, individual item fit, differential item functioning (DIF), local dependency, unidimensionality and person separation index (PSI)...
2018: Archives of Physiotherapy
Pras Pathmanathan, Richard A Gray
Computational models of cardiac electrophysiology have a long history in basic science applications and device design and evaluation, but have significant potential for clinical applications in all areas of cardiovascular medicine, including functional imaging and mapping, drug safety evaluation, disease diagnosis, patient selection, and therapy optimisation or personalisation. For all stakeholders to be confident in model-based clinical decisions, cardiac electrophysiological (CEP) models must be demonstrated to be trustworthy and reliable...
2018: Frontiers in Physiology
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