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https://www.readbyqxmd.com/read/29141753/serological-evaluation-of-cutaneous-leishmania-tropica-infection-in-northern-israel
#1
Iva Rohoušová, Dalit Talmi-Frank, Michaela Vlková, Tatiana Spitzová, Koranit Rishpon, Charles L Jaffe, Petr Volf, Gad Baneth, Moshe Efrat
Leishmania spp. are medically important unicellular parasites transmitted by phlebotomine sand flies. The World Health Organization recently highlighted the importance of reliable diagnostic tools for leishmaniasis. Our study of human infection was conducted in two endemic foci of Leishmania tropica in the Galilee region, northern Israel. Elevated anti-Leishmania antibodies were present in the majority (78.6%) of L. tropica-PCR positive individuals. Moreover, the enzyme-linked immunosorbent assay showed high sensitivity, specificity, and negative and positive predictive values (ranging between 73% and 79%), thus fulfilling the basic requirement for future development of a serodiagnostic and screening tool...
October 23, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29141436/surface-hopping-dynamics-including-intersystem-crossing-using-the-algebraic-diagrammatic-construction-method
#2
Sebastian Mai, Felix Plasser, Mathias Pabst, Frank Neese, Andreas Köhn, Leticia González
We report an implementation for employing the algebraic diagrammatic construction to second order [ADC(2)] ab initio electronic structure level of theory in nonadiabatic dynamics simulations in the framework of the SHARC (surface hopping including arbitrary couplings) dynamics method. The implementation is intended to enable computationally efficient, reliable, and easy-to-use nonadiabatic dynamics simulations of intersystem crossing in organic molecules. The methodology is evaluated for the 2-thiouracil molecule...
November 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29141146/the-effect-of-pressure-and-temperature-on-mid-infrared-sensing-of-dissolved-hydrocarbons-in-water
#3
Charles Heath, Matthew B Myers, Bobby Pejcic
Attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy using a polymer coated internal reflection element/waveguide is an established sensor platform for the detection of a range of organic and hydrocarbon molecules dissolved in water. The polymer coating serves two purposes: to concentrate hydrocarbons from the aqueous phase and to exclude water along with other interfering molecules from the surface of the internal reflection element. Crucial to reliable quantification and analytical performance is the calibration of the ATR-FTIR sensor which is commonly performed in water under mild ambient conditions (i...
November 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29140593/nursing-perception-of-risk-in-common-nursing-practice-situations
#4
Pamela Trevino, Angela Green, Donna Middaugh, Seonghum Heo, Claudia Beverly, Jayant Deshpande
As health care organizations seek to be highly reliable, systems that include layers of redundancy have been created to protect patients from harm. Many of these layers of protection are dependent on nurses making a decision to follow or adhere to the human aspects of the process. Because these decisions begin with a perception and identification of risk, understanding what nurses perceive to be a risk to patients is an essential part of designing safer health care systems. The purposes of this qualitative study were to (1) describe what nurses perceive as risky to patients in common nursing practice situations, (2) describe the effects of the perceptions of risk on clinical decision making and behavior, and (3) identify what factors nurses perceive as increasing or decreasing risk...
November 15, 2017: Journal of Healthcare Risk Management: the Journal of the American Society for Healthcare Risk Management
https://www.readbyqxmd.com/read/29139286/highly-sensitive-flexible-pressure-sensors-based-on-printed-organic-transistors-with-centro-apically-self-organized-organic-semiconductor-microstructures
#5
So Young Yeo, Sangsik Park, Yeonjin Yi, Do Hwan Kim, Jung Ah Lim
A highly sensitive pressure sensor based on a printed organic transistors with three-dimensionally self-organized organic semiconductor microstructures were demonstrated. A unique organic transistor with semiconductor channels positioned at the highest summit of printed cylindrical microstructures was achieved simply by printing an organic semiconductor and polymer blend on the plastic substrate without the use of additional etching or replication processes. A combination of the printed organic semiconductor microstructure and an elastomeric top-gate dielectric resulted in a highly sensitive OFET pressure sensor with a high pressure sensitivity of 1...
November 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29135516/international-endocervical-adenocarcinoma-criteria-and-classification-iecc-a-new-pathogenetic-classification-for-invasive-adenocarcinomas-of-the-endocervix
#6
Simona Stolnicu, Iulia Barsan, Lien Hoang, Prusha Patel, Cristina Terinte, Anna Pesci, Sarit Aviel-Ronen, Takako Kiyokawa, Isabel Alvarado-Cabrero, Malcolm C Pike, Esther Oliva, Kay J Park, Robert A Soslow
We sought to classify endocervical adenocarcinomas (ECAs) based on morphologic features linked to etiology (ie, human papillomavirus [HPV] infection), unlike the World Health Organization 2014 classification. The International Endocervical Adenocarcinoma Criteria and Classification (IECC criteria), described herein, distinguishes between human papillomavirus-associated adenocarcinoma (HPVA), recognized by the presence of luminal mitoses and apoptosis seen at scanning magnification, and no or limited HPVA features (nonhuman papillomavirus-associated adenocarcinoma [NHPVA])...
November 9, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29134292/simultaneous-determination-of-brazilin-and-protosappanin-b-in-caesalpinia-sappan-by-ionic-liquid-dispersive-liquid-phase-microextraction-method-combined-with-hplc
#7
Zhaoyang Xia, Dongdong Li, Qing Li, Yan Zhang, Wenyi Kang
The conditions of heating, ionic liquid-based ultrasonic-assisted extraction combined with reverse-phase high performance liquid chromatography were optimized to simultaneously isolate and determinate brazilin and protosappanin B in Caesalpinia sappan. Ionic liquids, including [BMIM]Br, [BMIM]BF4, [BMIM]PF6 and [HMIM]PF6, were selected as extraction solvents while methanol, acetone, acetonitrile, ethanol and water were selected as dispersants. The chromatographic column was Purospher star RP-C18 (250 mm × 4...
November 13, 2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/29133490/auscultation-while-standing-a-basic-and-reliable-method-to-rule-out-a-pathologic-heart-murmur-in-children
#8
Bruno Lefort, Elodie Cheyssac, Nathalie Soulé, Jacques Poinsot, Marie-Catherine Vaillant, Alaeddin Nassimi, Alain Chantepie
PURPOSE: The distinction between physiologic (innocent) and pathologic (organic) heart murmurs is not always easy in routine practice, leading too often to unnecessary cardiology referrals and expensive investigations. We aimed to test the hypothesis that the complete disappearance of murmur on standing can exclude cardiac disease in children. METHODS: From January 2014 to January 2015, we prospectively included 194 consecutive children aged 2 to 18 years who were referred for heart murmur evaluation to pediatric cardiologists at 2 French medical centers...
November 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/29132023/quantification-of-fluorescent-dyes-in-organ-tissue-samples-via-hplc-analysis
#9
S Morsbach, A García-Bardon, J Kamuf, B Müller, N Beghersa, K Mohr, K Landfester
The determination of regional blood flow via the accumulation of fluorescent microspheres is a concept regularly used in medical research. Typically, the microbeads get extracted from the tissue of interest and are then quantified by measuring the absorption or fluorescence of the incorporated dyes without further separation from the medium. However, in that case the absorption spectra of different dyes can overlap when used simultaneously, leading to an overestimation of the concentration. Additionally, background absorption from the medium can be problematic...
November 10, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29131647/on-the-efficient-construction-of-free-energy-profiles-of-breathing-metal-organic-frameworks-using-advanced-molecular-dynamics-simulations
#10
Ruben Demuynck, Sven M J Rogge, Louis Vanduyfhuys, Jelle Wieme, Michel Waroquier, Veronique Van Speybroeck
In order to reliably predict and understand the breathing behavior of highly flexible metal-organic frameworks from thermodynamic considerations, an accurate estimation of the free energy difference between their different metastable states is prerequisite. Herein, a variety of free energy estimation methods are thoroughly tested for their ability to construct the free energy profile as a function of the unit cell volume of MIL-53(Al). The methods comprise free energy perturbation, thermodynamic integration, umbrella sampling, metadynamics, and variationally enhanced sampling...
November 13, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29128717/in-vivo-bioelectronic-nose-using-transgenic-mice-for-specific-odor-detection
#11
Keqiang Gao, Songmin Li, Liujing Zhuang, Zhen Qin, Bin Zhang, Liquan Huang, Ping Wang
The olfactory system is a natural biosensor since its peripheral olfactory sensory neurons (OSNs) respond to the external stimuli and transmit the signals to the olfactory bulb (OB) where they are integrated and processed. The axonal connections from the OSNs expressing about 1000 different types of odorant receptors are precisely organized and sorted out onto 1800 glomeruli in the OB, from which the olfactory information is delivered to and perceived by the central nervous system. This process is carried out with particularly high sensitivity, specificity and rapidity, which can be used for explosive detection...
October 10, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29128122/resilience-of-carbon-and-nitrogen-removal-due-to-aeration-interruption-in-aerated-treatment-wetlands
#12
Johannes Boog, Jaime Nivala, Thomas Aubron, Sibylle Mothes, Manfred van Afferden, Roland A Müller
Treatment wetlands have long been used for domestic and industrial wastewater treatment. In recent decades, treatment wetland technology has evolved and now includes intensified designs such as aerated treatment wetlands. Aerated treatment wetlands are particularly dependent on aeration, which requires reliable air pumps and, in most cases, electricity. Whether aerated treatment wetlands are resilient to disturbances such as an aeration interruption is currently not well known. In order to investigate this knowledge gap, we carried out a pilot-scale experiment on one aerated horizontal flow wetland and one aerated vertical flow wetland under warm (Twater>17°C) and cold (Twater<10°C) weather conditions...
November 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29127837/usage-proposal-of-a-common-urban-decorative-tree-salix-alba-l-to-monitor-the-dispersion-of-gaseous-mercury-a-case-study-from-turda-romania
#13
J M Esbrí, H Cacovean, P Higueras
Closure of chloralkali plants poses a risk of abandonment of important sources of gaseous mercury. In this work, an assessment has been made of the potential for pollution from one of these plants in the proximity of a densely populated town in central Romania. The work involved a comparison between two major types of monitoring survey: biomonitoring using leaves of a tree common in urban environments; and LUMEX-based gaseous mercury analysis. For biomonitoring, 21 samples from Salix alba L. trees were taken in Turda area...
November 4, 2017: Chemosphere
https://www.readbyqxmd.com/read/29126428/validity-and-reliability-of-the-spanish-version-of-the-organizational-readiness-for-knowledge-translation-or4kt-questionnaire
#14
Gonzalo Grandes, Paola Bully, Catalina Martinez, Marie-Pierre Gagnon
BACKGROUND: Organizational readiness to change healthcare practice is a major determinant of successful implementation of evidence-based interventions. However, we lack of comprehensive, valid, and reliable instruments to measure it. We assessed the validity and reliability of the Spanish version of the Organizational Readiness for Knowledge Translation (OR4KT) questionnaire in the context of the implementation of the Prescribe Vida Saludable III project, which seeks to strengthen health promotion and chronic disease prevention in primary healthcare organizations of the Osakidetza (Basque Health Service, Spain)...
November 10, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/29124391/implementing-a-digital-real-time-hydrocephalus-and-shunt-registry-to-evaluate-contemporary-pattern-of-care-and-surgical-outcome-in-pediatric-hydrocephalus
#15
Hans Christoph Bock, Maximilian Kanzler, Ulrich-Wilhelm Thomale, Hans Christoph Ludwig
OBJECTIVE: Treatment monitoring and outcome evaluation in pediatric hydrocephalus require gapless documentation regarding surgical and clinical follow-up data beginning from day 1 of treatment in order to apply high quality of care. Endoscopic procedures, shunt insertion and revision surgeries, and individual modifications of valve hardware or pressure settings during follow-up as well as established outcome measurements are highly relevant for complete illustration of the patient's hydrocephalus histories...
November 9, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29123545/identification-and-characterization-of-micrornas-in-the-goat-capra-hircus-rumen-during-embryonic-development
#16
Tao Zhong, Jiangtao Hu, Ping Xiao, Siyuan Zhan, Linjie Wang, Jiazhong Guo, Li Li, Hongping Zhang, Lili Niu
The rumen is an important digestive organ in ruminants. Numerous regulatory factors including microRNAs (miRNAs) are involved in embryonic organ development. In the present study, miRNAs expressed in the rumens of goats (Capra hircus) and their potential roles in the pathways involved in rumen development were identified using high-throughput sequencing. Histological morphology revealed a distinct difference in each layer of rumen during the period from embryonic day 60 (E60) to embryonic day 135 (E135). We determined the expression profiles of miRNAs in the goat rumen, and identified 423 known miRNAs and 559 potentially novel miRNAs in the E60 and E135 embryonic rumen, respectively...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29122672/influence-of-high-carbon-basal-fertiliser-on-the-structure-and-composition-of-a-soil-microbial-community-under-tobacco-cultivation
#17
Song-Tao Zhang, Xiao-Ning Song, Ning Li, Ke Zhang, Guo-Shun Liu, Xue-Dong Li, Zhi-Zhong Wang, Xiao-Bing He, Guo-Feng Wang, Hui-Fang Shao
Soil microorganisms play a crucial role in cycling soil nutrients and providing organic nutrients for plant growth and development. Fertilisation balances soil fertility and quality, and affects soil microbial communities. Fertilisation is a frontier subject in agricultural and environmental sciences. Here we showed that the application of high-carbon basal fertiliser treatment could improve the tobacco yield and quality when compared to chemical fertiliser, high-carbon basal fertiliser and mixed high-carbon chemical fertiliser...
November 7, 2017: Research in Microbiology
https://www.readbyqxmd.com/read/29122489/reliability-and-reproducibility-of-the-american-association-for-the-surgery-of-trauma-scaling-for-renal-injury-and-impact-on-radiologic-follow-up
#18
Q-B Phan, E Mourey, L Estivalet, B Delattre, F Bardet, O Chevallier, D Louis, L S Aho, R Loffroy, L Cormier
INTRODUCTION: The American Association for the Surgery of Trauma (AAST) Organ Injury Scale (OIS) is the most used classification for renal trauma. It determines the radiologic monitoring, only recommended for high-grade injuries. The aim of this study was to assess the subjectivity of AAST scaling and its impact on short-term follow-up. METHODS: We retrospectively reviewed all patients with blunt renal injuries admitted at a university hospital between 2010 and 2015...
November 6, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/29119352/using-physics-based-pose-predictions-and-free-energy-perturbation-calculations-to-predict-binding-poses-and-relative-binding-affinities-for-fxr-ligands-in-the-d3r-grand-challenge-2
#19
Christina Athanasiou, Sofia Vasilakaki, Dimitris Dellis, Zoe Cournia
Computer-aided drug design has become an integral part of drug discovery and development in the pharmaceutical and biotechnology industry, and is nowadays extensively used in the lead identification and lead optimization phases. The drug design data resource (D3R) organizes challenges against blinded experimental data to prospectively test computational methodologies as an opportunity for improved methods and algorithms to emerge. We participated in Grand Challenge 2 to predict the crystallographic poses of 36 Farnesoid X Receptor (FXR)-bound ligands and the relative binding affinities for two designated subsets of 18 and 15 FXR-bound ligands...
November 8, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/29117710/psychometric-properties-of-the-frost-multidimensional-perfectionism-scale-in-spanish-children-and-adolescents
#20
Aurora Gavino, Raquel Nogueira, Lucía Pérez-Costillas, Antonio Godoy
The Frost Multidimensional Perfectionism Scale (FMPS) is one of the most used instruments to assess perfectionism. The FMPS assesses six dimensions: Concern over Mistakes (CM), Parental Expectations (EP), Parental Criticism (PC), Doubts about Actions (DA), Organization (OR), and Personal Standards (PS). CM, PE, PC, and DA are facets of a more general dimension considered Maladaptive Perfectionism. PS is frequently considered Adaptive Perfectionism. FMPS psychometric properties have been studied in adults but scarcely in children...
November 1, 2017: Assessment
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