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https://www.readbyqxmd.com/read/29031132/effectiveness-of-policy-changes-to-reduce-harm-from-unrecorded-alcohol-in-russia-between-2005-and-now
#1
Maria Neufeld, Jürgen Rehm
BACKGROUND: Consumption of unrecorded alcohol (alcohol that is not taxed and reflected in official statistics, but consumed as a beverage) has been identified as one of the main contributors to alcohol-attributable premature mortality in Russia. The problem was highlighted by a recent a mass poisoning with surrogate alcohol occurred in the Siberian city of Irkutsk. METHODS: Based on key publications and legislative documents, a narrative review was undertaken about alcohol-related harm reduction policies in Russia for the period between 2005 and 2017, as well as the impact of these policies on the recorded and unrecorded alcohol consumption and alcohol market...
October 11, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29027649/sex-specific-effects-of-combined-exposure-to-chemical-and-non-chemical-stressors-on-neuroendocrine-development-a-review-of-recent-findings-and-putative-mechanisms
#2
REVIEW
Whitney J Cowell, Rosalind J Wright
PURPOSE OF REVIEW: Environmental toxicants and psychosocial stressors share many biological substrates and influence overlapping physiological pathways. Increasing evidence indicates stress-induced changes to the maternal milieu may prime rapidly developing physiological systems for disruption by concurrent or subsequent exposure to environmental chemicals. In this review, we highlight putative mechanisms underlying sex-specific susceptibility of the developing neuroendocrine system to the joint effects of stress or stress correlates and environmental toxicants (bisphenol A, alcohol, phthalates, lead, chlorpyrifos, and traffic-related air pollution)...
October 13, 2017: Current Environmental Health Reports
https://www.readbyqxmd.com/read/29027262/on-the-origins-and-industrial-applications-of-saccharomyces-cerevisiae-x-saccharomyces-kudriavzevii-hybrids
#3
David Peris, Roberto Pérez-Torrado, Chris Todd Hittinger, Eladio Barrio, Amparo Querol
Companies based on alcoholic fermentation products, such as wine, beer, and biofuels, use yeasts to make their products. Each industrial process utilizes different media conditions, which differ in sugar content, the presence of inhibitors, and fermentation temperatures. Saccharomyces cerevisiae has traditionally been the main yeast responsible for most fermentation processes. However, the market is changing due to the consumer demands or external factors, such as climate change. Some processes, such as biofuel production or winemaking, require new yeasts to solve specific challenges, especially those associated with sustainability, novel flavors, and altered alcohol contents...
October 12, 2017: Yeast
https://www.readbyqxmd.com/read/29024552/current-pharmacotherapies-for-obesity-a-practical-perspective
#4
Angela Golden
BACKGROUND AND PURPOSE: To review the currently available pharmacotherapies for obesity management with a particular focus on the United States. METHODS: Narrative review based on literature searches and the latest prescribing information (up to July 2017). CONCLUSIONS: Obesity pharmacotherapies may assist those individuals who have obesity, or overweight with comorbidities, who have failed to maintain weight loss with lifestyle modifications alone (caloric restriction and increased physical activity)...
October 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29021422/non-linear-association-between-alcohol-and-incident-frailty-among-community-dwelling-older-people-a-dose-response-meta-analysis
#5
Gotaro Kojima, Steve Iliffe, Ann Liljas, Kate Walters
A recent systematic review and meta-analysis study suggested that higher alcohol consumption is associated with lower risks for frailty. However the apparent protective effect may not be true because of some limitations. Therefore we further explored potential linear and non-linear associations using a two-stage dose-response meta-analysis. Restricted cubic splines were applied with three fixed knots at percentiles (10%, 50%, and 90%). A two-stage dose-response meta-analysis showed a significant non-linear association (p for non-linearity < 0...
October 11, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/29021249/prescribing-ppis
#6
(no author information available yet)
Proton pump inhibitors (PPIs) are widely prescribed and many people remain on them for years. In some, there may be good justification for long-term use; for example, in those with oesophageal stricture, Barrett's oesophagus or a history of a bleeding gastrointestinal ulcer, or to provide gastroprotection in those at high risk of gastrointestinal complications from taking NSAIDs. However, PPIs are often not used in line with clinical guidelines.(1,2) In addition, there are concerns that many people take them for long periods to manage less serious conditions (e...
October 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/29021117/there-is-an-app-for-that-or-is-there-a-content-analysis-of-publicly-available-smartphone-apps-for-managing-alcohol-use
#7
Bettina B Hoeppner, Melissa R Schick, Lourah M Kelly, Susanne S Hoeppner, Brandon Bergman, John F Kelly
INTRODUCTION: Smartphone apps are emerging as a promising tool to support recovery from and prevention of problematic alcohol use, yet it is unclear what type of apps are currently available in the public domain, and to what degree these apps use interactive tailoring or other dynamic features to meet users' specific needs. METHODS: We conducted a content analysis of Android apps for managing drinking available on Google Play (n=266), downloaded between November 21, 2014 and June 25, 2015...
November 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29020729/diagnosing-and-managing-androgen-deficiency-in-men
#8
Raveen Kaur Sandher, Jonathan Aning
Androgens play a crucial role in bone, muscle and fat metabolism, erythropoiesis and cognitive health. In men aged 40-79 years the incidence of biochemical deficiency and symptomatic hypogonadism is 2.1-5.7%. Decreased libido or reduced frequency and quality of erections, fatigue, irritability, infertility or a diminished feeling of wellbeing may be presenting complaints. However, a significant proportion of men with androgen deficiency will be identified when they present for unrelated concerns. Important factors to elicit from the history in addition to the presenting complaint include: a medical history of obesity, type 2 diabetes, systemic diseases or metabolic syndrome which all impact on testosterone physiology...
April 2017: Practitioner
https://www.readbyqxmd.com/read/29018553/suicide-patterns-on-the-london-underground-railway-system-2000-2010
#9
Susanna Martin, Muffazal Rawala
Aims and Method Suicidal acts on underground railway networks are an area of public health concern. Our aim was to review recent epidemiological patterns of suicidal acts on the London Underground to inform future preventive interventions. Data from 2000 to 2010 were obtained from the British Transport Police via a Freedom of Information request. Results The mean annual rate of suicidal acts from 2000 to 2010 was 5.8 per 100 million passenger journey stages. Of those who died by suicide, 77.3% were of White Northern European ethnicity...
October 2017: BJPsych Bulletin
https://www.readbyqxmd.com/read/29018367/treatment-of-comorbid-alcohol-dependence-and-anxiety-disorder-review-of-the-scientific-evidence-and-recommendations-for-treatment
#10
REVIEW
Carmen Gimeno, Marisa Luisa Dorado, Carlos Roncero, Nestor Szerman, Pablo Vega, Vicent Balanzá-Martínez, F Javier Alvarez
Patients with alcohol-use disorders (AUDs) have a high prevalence of anxiety disorders (AnxDs). "Co-occurring disorders" refers to the coexistence of an AUD and/or drug related disorders with another non-addictive psychiatric disorder. The aim of this study was to assess the effectiveness of psychopharmacological treatments and psychotherapy in patients with AUD and AnxD and to propose recommendations for the treatment of patients with comorbid AnxDs and AUDs. Randomized clinical trials, meta-analyses, and clinical guidelines were retrieved from PubMed, Embase, and Cochrane databases...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29017023/maternal-iron-nutriture-as-a-critical-modulator-of-fasd-risk-in-alcohol-exposed-pregnancies
#11
Kaylee K Helfrich, Nipun Saini, Pamela J Kling, Susan M Smith
Alcohol consumption during pregnancy places the fetus at risk for permanent physical, cognitive, and behavioral impairments, collectively termed fetal alcohol spectrum disorders (FASD). However, prenatal alcohol exposure (PAE) outcomes vary widely, and growing evidence suggests that maternal nutrition is a modifying factor. Certain nutrients, such as iron, may modulate FASD outcomes. Untreated gestational iron deficiency (ID) causes persistent neurodevelopmental deficits in the offspring that affect many of the same domains damaged by PAE...
October 10, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29016249/factors-associated-with-obesity-and-metabolic-syndrome-in-ageing-black-south-african-women
#12
Philippe Jean-Luc Gradidge
BACKGROUND: The incidence of obesity and related metabolic diseases is high and increasing in sub-Saharan African women. Evidence on the determinants of these diseases is limited, particularly in black South African women. OBJECTIVE: This PhD review attempts to understand the determinants of obesity and metabolic syndrome (MetS) in a population of ageing urban-dwelling black South African women. METHODS: Drawing on the longitudinal Birth-to-Twenty-Plus cohort, data were collected in 2002/03 and 2012/13, including information on behavioural factors (smoking, sitting time, physical activity, smokeless tobacco, and alcohol consumption), body-size perception, body composition (measures of adiposity and lean mass), blood pressure, and cardiometabolic biomarkers (lipid profile, fasting insulin, fasting blood glucose, insulin resistance, leptin, and adiponectin)...
2017: Global Health Action
https://www.readbyqxmd.com/read/28994854/alkoholketoacidos-%C3%A3-r-en-v%C3%A3-l-dokumenterad-men-t%C3%A3-mligen-ok%C3%A3-nd-diagnos-m%C3%A3-jlig-orsak-till-d%C3%A3-dsfall-bland-personer-med-alkoholproblem
#13
Jonas Höjer
Alcoholic ketoacidosis - a review A chronic alcoholic with severe metabolic acidosis presents a difficult diagnostic problem in the emergency room. Over and above methanol- and ethylene glycol intoxication, alcoholic ketoacidosis is a common but less recognized etiology. The disorder occurs in alcoholics who have had a recent binge drinking followed by the abrupt cessation of alcohol consumption because of abdominal pain and vomiting, with resulting dehydration, starvation, and then a β-hydroxybutyrate dominated ketoacidosis...
October 3, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28993373/wine-and-cardiovascular-health-a-comprehensive-review
#14
REVIEW
Sohaib Haseeb, Bryce Alexander, Adrian Baranchuk
Alcoholic beverages have been consumed for thousands of years, attracting great human interest for social, personal, and religious occasions. In addition, they have long been debated to confer cardioprotective benefits. The French Paradox is an observation of a low prevalence of ischemic heart disease, with high intakes of saturated fat, a phenomenon accredited to the consumption of red wine. Although many epidemiological investigations have supported this view, others have attributed it to beer or spirits, with many suggesting that the drink type is not important...
October 10, 2017: Circulation
https://www.readbyqxmd.com/read/28990516/gut-microbiota-as-a-therapeutic-target-for-metabolic-disorders
#15
Hirofumi Okubo, Yusuke Nakatsu, Akifumi Kushiyama, Takeshi Yamamotoya, Yasuka Matsunaga, Masa-Ki Inoue, Midori Fujishiro, Hideaki Sakoda, Haruya Ohno, Masayasu Yoneda, Hiraku Ono, Tomoichiro Asano
The prevalence of metabolic disorders has been rising worldwide, making the identification of factors affecting metabolic control more important than ever. Gut microbiota play a vital role not only in the digestion and absorption of nutrients, but also in homeostatic maintenance of host immunity, metabolism and the gut barrier. It was recently suggested that gut microbiota alterations contribute to the pathogenesis of metabolic disorders such as obesity, diabetes mellitus and non-alcoholic fatty liver disease...
October 9, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28989978/the-therapeutic-potential-of-resveratrol-a-review-of-clinical-trials
#16
Adi Y Berman, Rachel A Motechin, Maia Y Wiesenfeld, Marina K Holz
Resveratrol is a nutraceutical with several therapeutic effects. It has been shown to mimic effects of caloric restriction, exert anti-inflammatory and anti-oxidative effects, and affect the initiation and progression of many diseases through several mechanisms. While there is a wealth of in vitro and in vivo evidence that resveratrol could be a promising therapeutic agent, clinical trials must confirm its potential. In this work, we reviewed the current clinical data available regarding the pharmacological action of resveratrol...
2017: NPJ Precis Oncol
https://www.readbyqxmd.com/read/28989700/toxicological-implications-of-mitochondrial-localization-of-cyp2e1
#17
Jessica H Hartman, Grover P Miller, Joel N Meyer
Cytochrome P450 2E1 (CYP2E1) metabolizes an extensive array of pollutants, drugs, and other small molecules, often resulting in bioactivation to reactive metabolites. Therefore, it is unsurprising that it has been the subject of decades of research publications and reviews. However, while CYP2E1 has historically been studied in the endoplasmic reticulum (erCYP2E1), active CYP2E1 is also present in mitochondria (mtCYP2E1). Relatively few studies have specifically focused on mtCYP2E1, but there is growing interest in this form of the enzyme as a driver in toxicological mechanisms given its activity and location...
2017: Toxicology Research
https://www.readbyqxmd.com/read/28989564/diffusion-weighted-magnetic-resonance-imaging-of-liver-principles-clinical-applications-and-recent-updates
#18
REVIEW
Anuradha Shenoy-Bhangle, Vinit Baliyan, Hamed Kordbacheh, Alexander R Guimaraes, Avinash Kambadakone
Diffusion-weighted imaging (DWI), a functional imaging technique exploiting the Brownian motion of water molecules, is increasingly shown to have value in various oncological and non-oncological applications. Factors such as the ease of acquisition and ability to obtain functional information in the absence of intravenous contrast, especially in patients with abnormal renal function, have contributed to the growing interest in exploring clinical applications of DWI. In the liver, DWI demonstrates a gamut of clinical applications ranging from detecting focal liver lesions to monitoring response in patients undergoing serial follow-up after loco-regional and systemic therapies...
September 18, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28988969/fetal-alcohol-spectrum-disorders-zebrafish-in-the-analysis-of-the-milder-and-more-prevalent-form-of-the-disease
#19
REVIEW
Diane Seguin, Robert Gerlai
Fetal Alcohol Spectrum Disorders (FASD) represent a large unmet medical need. Exposure of the developing human embryo to alcohol can lead to life-long suffering. Despite the well documented deleterious effects of alcohol on the developing fetus, pregnant women continue to drink alcohol, and FASD remains the leading cause of preventable mental retardation and other behavioral abnormalities. Particularly prevalent are the milder forms of the disease cluster, representing children who do not show obvious physical signs and who may be undiagnosed or misdiagnosed...
October 5, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28988575/alcohol-s-effects-on-the-cardiovascular-system
#20
Mariann R Piano
Alcohol use has complex effects on cardiovascular (CV) health. The associations between drinking and CV diseases such as hypertension, coronary heart disease, stroke, peripheral arterial disease, and cardiomyopathy have been studied extensively and are outlined in this review. Although many behavioral, genetic, and biologic variants influence the interconnection between alcohol use and CV disease, dose and pattern of alcohol consumption seem to modulate this most. Low-to-moderate alcohol use may mitigate certain mechanisms such as risk and hemostatic factors affecting atherosclerosis and inflammation, pathophysiologic processes integral to most CV disease...
2017: Alcohol Research: Current Reviews
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