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https://www.readbyqxmd.com/read/28088091/solar-to-chemical-and-solar-to-fuel-production-from-co2-by-metabolically-engineered-microorganisms
#1
REVIEW
Han Min Woo
Recent development of carbon capture utilization (CCU) for reduction of greenhouse gas emission are reviewed. In the case of CO2 utilization, I describe development of solar-to-chemical and solar-to-fuel technology that refers to the use of solar energy to convert CO2 to desired chemicals and fuels. Photoautotrophic cyanobacterial platforms have been extensively developed on this principle, producing a diverse range of alcohols, organic acids, and isoprenoids directly from CO2. Recent breakthroughs in the metabolic engineering of cyanobacteria were reviewed...
January 11, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28087569/exercise-as-treatment-for-alcohol-use-disorders-systematic-review-and-meta-analysis
#2
Mats Hallgren, Davy Vancampfort, Esther S Giesen, Andreas Lundin, Brendon Stubbs
OBJECTIVES: To conduct a systematic review and meta-analysis investigating effects of exercise for people with alcohol use disorders (AUDs) across multiple health outcomes. We also investigated the prevalence and predictors of dropout from exercise studies in AUDs. DESIGN: Systematic review and random effects meta-analysis with meta-regression analyses. DATA SOURCES: 3 major electronic databases were searched from inception until April 2016 for exercise intervention studies in adults with AUDs...
January 13, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28080095/the-proximal-effects-of-acute-alcohol-use-on-female-aggression-a-meta-analytic-review-of-the-experimental-literature
#3
Cory A Crane, MacKenzie L Licata, Robert C Schlauch, Maria Testa, Caroline J Easton
Experimental research on alcohol-related aggression has focused largely upon male participants, providing only a limited understanding of the proximal effects of acute alcohol use on aggression among females extrapolated from the male literature. The current meta-analysis was undertaken to summarize the effects of alcohol, compared to placebo or no alcohol, on female aggression as observed across experimental investigations. A review of the literature yielded 11 articles and 12 effect sizes for further analysis...
January 12, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/28078997/lipoprotein-a-and-cardiovascular-risk-the-show-must-go-on
#4
Niki Katsiki, Khalid Al-Rasadi, Dimitri P Mikhailidis
Lipoprotein (a) [Lp(a)] is an independent but moderate, predictor for coronary heart disease (CHD) prevalence and severity. Several established and emerging cardiovascular (CV) risk factors including age, gender, ethnicity, smoking, dyslipidemia, hypertension, obesity, type 2 diabetes mellitus, alcohol consumption, arterial stiffness and hyperuricemia have been linked to Lp(a) metabolism. Apart from CHD, Lp(a) has been also associated with non-cardiac vascular diseases and diseases associated with increased CV risk such as chronic kidney disease, metabolic syndrome, non-alcoholic fatty liver disease, erectile dysfunction, obstructive sleep apnea syndrome, inflammatory bowel diseases and human immunodeficiency virus infection...
January 12, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28078396/a-genetic-method-to-enhance-the-accumulation-of-s-adenosylmethionine-in-yeast
#5
REVIEW
Muneyoshi Kanai, Masaki Mizunuma, Tsutomu Fujii, Haruyuki Iefuji
S-Adenosylmethionine (SAM) is a key component of sulphur amino acid metabolism in living organisms and is synthesised from methionine and adenosine triphosphate by methionine adenosyltransferase. This molecule serves as the main biological methyl donor due to its active methylthio ether group. Notably, SAM has shown beneficial effects in clinical trials for the treatment of alcoholic liver disease, depression and joint pain. Due to the high potential value of SAM, current research efforts are attempting to develop a more rapid, cost-effective and higher yielding SAM production method than the conventional production system...
January 11, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28078209/cognitive-behavioural-therapy-for-obsessive-compulsive-disorder-co-occurring-with-psychosis-systematic-review-of-evidence
#6
Antonio Tundo, Roberta Necci
AIM: To review available evidence on the use of cognitive behavioural therapy (CBT) for treating obsessive compulsive disorder co-occurring with psychosis. METHODS: In this paper we present a detailed and comprehensive review of the current literature focusing on CBT treatment of obsessive compulsive disorder (OCD) co-occurring with schizophrenia or schizoaffective disorder. We identified relevant literature published between 2001 and May 2016 through MEDLINE/PubMed search using as search string ("obsessive compulsive disorders" or "obsessive compulsive symptoms") and ("schizophrenia" or "schizoaffective disorder" or "psychosis") and ("cognitive behavioural therapy")...
December 22, 2016: World Journal of Psychiatry
https://www.readbyqxmd.com/read/28077863/what-have-human-experimental-overfeeding-studies-taught-us-about-adipose-tissue-expansion-and-susceptibility-to-obesity-and-metabolic-complications
#7
REVIEW
D J Cuthbertson, T Steele, J P Wilding, J C G Halford, J A Harrold, M Hamer, F Karpe
Overfeeding experiments, in which we impose short-term positive energy balance, help unravel the cellular, physiological and behavioural adaptations to nutrient excess. These studies mimic longer-term mismatched energy expenditure and intake. There is considerable inter-individual heterogeneity in the magnitude of weight gain when exposed to similar relative caloric excess reflecting variable activation of compensatory adaptive mechanisms. Significantly, given similar relative weight gain, individuals may be protected from/predisposed to metabolic complications (insulin resistance, dyslipidaemia, hypertension), non-alcoholic fatty liver disease and cardiovascular disease...
January 12, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28077318/alcohol-microbiome-life-style-influence-alcohol-and-non-alcoholic-organ-damage
#8
REVIEW
Manuela G Neuman, Samuel W French, Samir Zakhari, Stefen Malnick, Helmut K Seitz, Lawrence B Cohen, Mikko Salaspuro, Andreea Voinea Griffin, Andrei Barasch, Irina A Kirpich, Paul G Thomes, Laura W Schrum, Terrence M Donohue, Kusum Kharbanda, Marcus Cruz, Mihai Opris
This paper is based upon the "8th Charles Lieber's Satellite Symposium" organized by Manuela G. Neuman at the Research Society on Alcoholism Annual Meeting, onJune 25, 2016 at New Orleans, Louisiana, USA. The integrative symposium investigated different aspects of alcohol-induced liver disease (ALD) as well as non-alcohol-induced liver disease (NAFLD) and possible repair. We revealedthe basic aspects of alcohol metabolism that may be responsible for the development of liver diseaseas well as the factors that determine the amount, frequency and which type of alcohol misuse leads to liver and gastrointestinal diseases...
January 7, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28077126/what-do-we-know-about-the-effects-of-exposure-to-low-alcohol-and-equivalent-product-labelling-on-the-amounts-of-alcohol-food-and-tobacco-people-select-and-consume-a-systematic-review
#9
Ian Shemilt, Vivien Hendry, Theresa M Marteau
BACKGROUND: Explicit labelling of lower strength alcohol products could reduce alcohol consumption by attracting more people to buy and drink such products instead of higher strength ones. Alternatively, it may lead to more consumption due to a 'self-licensing' mechanism. Equivalent labelling of food or tobacco (for example "Low fat" or "Low tar") could influence consumption of those products by similar mechanisms. This systematic review examined the effects of 'Low alcohol' and equivalent labelling of alcohol, food and tobacco products on selection, consumption, and perceptions of products among adults...
January 12, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28076834/risk-factors-for-posttraumatic-epilepsy-a-systematic-review-and-meta-analysis
#10
REVIEW
Tao Xu, Xinyuan Yu, Shu Ou, Xi Liu, Jinxian Yuan, Hao Huang, Juan Yang, Liang He, Yangmei Chen
OBJECTIVE: A systematic review and meta-analysis was performed to identify risk factors for posttraumatic epilepsy (PTE). METHODS: Two electronic databases (Medline and Embase) were searched to identify studies with a cohort, case-control, or cross-sectional design reporting on epidemiologic evidence regarding risk factors for PTE. RESULTS: Men had a higher risk of developing PTE than women [relative ratio (RR), 1.32; 95% confidence interval (CI), 1...
January 8, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28074225/recent-advances-in-biotechnological-applications-of-alcohol-dehydrogenases
#11
REVIEW
Yu-Guo Zheng, Huan-Huan Yin, Dao-Fu Yu, Xiang Chen, Xiao-Ling Tang, Xiao-Jian Zhang, Ya-Ping Xue, Ya-Jun Wang, Zhi-Qiang Liu
Alcohol dehydrogenases (ADHs), which belong to the oxidoreductase superfamily, catalyze the interconversion between alcohols and aldehydes or ketones with high stereoselectivity under mild conditions. ADHs are widely employed as biocatalysts for the dynamic kinetic resolution of racemic substrates and for the preparation of enantiomerically pure chemicals. This review provides an overview of biotechnological applications for ADHs in the production of chiral pharmaceuticals and fine chemicals.
January 10, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28073872/gambling-disorder-a-side-effect-of-an-off-label-prescription-of-baclofen-literature-review
#12
Morgane Guillou-Landreat, Caroline Victorri Vigneau, Marie Gerardin
The use of high-dose baclofen emerged in 2008 in the treatment of alcohol-use disorders. Its prescription is still off-label in France, but recent trials have suggested the interest of using high doses for alcohol dependence, so we have to deal with an increase in its use. However, we still have few data about the adverse effects of a high-dose baclofen prescription, especially in complex addictive disorders. We present a case of a 32-year-old man who sought treatment for gambling disorders (GDs). He had complex addictive disorders, including alcohol-use disorders and GDs...
January 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28073428/formation-of-charge-carriers-in-liquids
#13
Dennis C Prieve, Benjamin A Yezer, Aditya S Khair, Paul J Sides, James W Schneider
After presenting a brief historical overview of the classic contributions of Faraday, Arrhenius, Kohlrausch, Bjerrum, Debye, Hückel and Onsager to understanding the conductivity of true electrolytes in aqueous solutions, we present an in-depth review of the 1933 work of Fuoss & Kraus who explored the effect of the solvent on electrolyte dissociation equilibria in either polar or nonpolar media. Their theory predicts that the equilibrium constant for dissociation decays exponentially with the ratio of the Bjerrum length λB to the ion-pair size a...
November 19, 2016: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28073422/-research-advances-in-the-association-between-deacetylase-sirtuin3-and-liver-diseases
#14
J Yu, C Chen, W X Wang
The deacetylase Sirtuin 3 (SIRT3) is a member of the Sirtuins mainly located in the mitochondrial matrix, and as a nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase, it can regulate cellular energy metabolism and oxidative stress-related pathways. The liver is the largest solid organ in the human body and plays a very important role in substance metabolism. Based on the features of SIRT3, it is closely associated with the development and progression of certain liver diseases. This article reviews the research advances in the role of SIRT3 in non-alcoholic fatty liver disease, liver cancer, and hepatic ischemia-reperfusion injury...
December 20, 2016: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/28073139/-influence-of-comorbidities-on-revision-rate-within-the-first-year-after-primary-total-hip-arthroplasty
#15
Roman Nesslage, Kerstin Radtke, Lisa Hohloch, Thilo Flörkemeier, Henning Windhagen, Gabriela von Lewinski
: Background Total hip arthroplasty (THA) is very frequently performed. Despite low complication rates, revisions play an important clinical and economical role. The aim of this study was to identify comorbid diseases of patients undergoing primary THA and their potential influence on the survival of hip replacements. Patients/Material and Methods A total of 867 patients were included in this retrospective study. All revisions were reviewed that took place at our hospital within one year of primary implantation of THA...
January 10, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28072668/genital-and-extragenital-gonorrhea-and-chlamydia-in-children-and-adolescents-evaluated-for-sexual-abuse
#16
Nancy D Kellogg, John D Melville, James L Lukefahr, Shalon M Nienow, Edward L Russell
OBJECTIVE: The aim of this study was to describe the use of a nucleic acid amplification test in detecting genital and extragenital Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) in children and adolescents assessed for sexual abuse/assault. METHODS: The charts of children aged 0 to 17 years, consecutively evaluated for sexual victimization, in emergency department and outpatient settings were reviewed. Data extracted included age, sex, type of sexual contact, anogenital findings, previous sexual contact, toxicology results, and sites tested for NG and CT...
January 9, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28071621/assessment-of-the-sociodemographic-characteristics-and-efficacy-of-screening-for-oral-head-and-neck-potential-malignant-lesions-in-apparently-healthy-adults-in-jos-nigeria
#17
A A Adoga, O A Silas, J P Yaro, E T Okwori, A A Iduh, C J Mgbachi
BACKGROUND: The efficacy of screening for oral, head and neck cancers (HNCs) in adequately identifying high-risk groups is controversial. OBJECTIVES: This study aims to review our experience with a free oral, HNC-screening program to determine the sociodemographic characteristics of the participants and the effectiveness of this program to improve future programs. MATERIALS AND METHODS: A prospective cross-sectional survey of participants in a free oral, HNC screening exercise was performed in the years 2009, 2012, and 2013...
April 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28068977/alcohol-management-plans-in-aboriginal-and-torres-strait-islander-indigenous-australian-communities-in-queensland-community-residents-have-experienced-favourable-impacts-but-also-suffered-unfavourable-ones
#18
Alan R Clough, Stephen A Margolis, Adrian Miller, Anthony Shakeshaft, Christopher M Doran, Robyn McDermott, Robert Sanson-Fisher, Valmae Ypinazar, David Martin, Jan A Robertson, Michelle S Fitts, Katrina Bird, Bronwyn Honorato, Simon Towle, Caryn West
BACKGROUND: In Australia, 'Alcohol Management Plans' (AMPs) provide the policy infrastructure for State and Commonwealth Governments to address problematic alcohol use among Aboriginal and Torres Strait Islanders. We report community residents' experiences of AMPs in 10 of Queensland's 15 remote Indigenous communities. METHODS: This cross-sectional study used a two-stage sampling strategy: N = 1211; 588 (48%) males, 623 (52%) females aged ≥18 years in 10 communities...
January 10, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28065744/efficacy-and-safety-of-glucagon-like-peptide-1-receptor-agonists-in-non-alcoholic-fatty-liver-disease-a-systematic-review-and-meta-analysis
#19
Yajie Dong, Qingguo Lv, Sheyu Li, Yuan Wu, Ling Li, Juan Li, Fang Zhang, Xin Sun, Nanwei Tong
BACKGROUND AND OBJECTIVE: New drugs are urgently needed for the treatment of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). The aim of this meta-analysis was to evaluate the efficacy and safety of glucagon-like peptide-1 receptor agonists (GLP-1RAs) in NAFLD/NASH. METHODS: We searched the MEDLINE, Embase, and Cochrane Library Central to identify randomized controlled trials (RCTs) and observational studies that compared GLP-1RAs with a control treatment or baseline values with respect to efficacy and safety in patients with NAFLD/NASH...
January 5, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28064151/supervised-disulfiram-s-superior-effectiveness-in-alcoholism-treatment-ethical-methodological-and-psychological-aspects
#20
REVIEW
Colin Brewer, Emmanuel Streel, Marilyn Skinner
Disulfiram (DSF) causes the ALDH-mediated deterrence of alcohol consumption. We review recent meta-analyses showing the superior effectiveness of supervised disulfiram (SD) in alcoholism treatment compared with oral naltrexone or acamprosate (ACP). The success of SD is also consistent with the almost complete absence of alcoholism in Japanese homozygotes for 'inefficient' ALDH. However, SD is an underused treatment and some clinicians have ethical objections to DSF. We examine these objections and argue that they are based on a misunderstanding of how DSF works...
January 7, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
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