keyword
https://read.qxmd.com/read/38547205/changes-in-the-intestinal-microbiota-of-individuals-with-non-alcoholic-fatty-liver-disease-based-on-sequencing-an-updated-systematic-review-and-meta-analysis
#1
JOURNAL ARTICLE
Wenpin Cai, Ting Qiu, Weitao Hu, Taiyong Fang
BACKGROUND: Alterations in the composition and abundance of the intestinal microbiota occur in non-alcoholic fatty liver disease (NAFLD). However, the results are inconsistent because of differences in the study design, subject area, and sequencing methodology. In this study, we compared the diversity and abundance of the intestinal microbiota of patients with NAFLD and healthy individuals through a systematic review and meta-analysis. METHODS: Three databases (PubMed, EMBASE, and Cochrane Library) were searched from their inception to March 20, 2023...
2024: PloS One
https://read.qxmd.com/read/38546884/an-updated-systematic-review-of-neuroprotective-agents-in-the-treatment-of-spinal-cord-injury
#2
REVIEW
Ibrahim Serag, Mohamed Abouzid, Ahmed Elmoghazy, Khalid Sarhan, Saad Ashraf Alsaad, Rashad G Mohamed
This systematic review aims to summarize the findings from all clinical randomized trials assessing the efficacy of potential neuroprotective agents in influencing the outcomes of acute spinal cord injuries (SCI). Following the PRISMA guidelines, we conducted comprehensive searches in four electronic databases (PubMed, Scopus, Cochrane Library, and Web of Science) up to September 5th, 2023. Our analysis included a total of 30 studies. We examined the effects of 15 substances/drugs: methylprednisolone, tirilazad mesylate, erythropoietin, nimodipine, naloxone, Sygen, Rho protein antagonist, granulocyte colony-stimulating factor, autologous macrophages, autologous bone marrow cells, vitamin D, progesterone, riluzole, minocycline, and blood alcohol concentration...
March 28, 2024: Neurosurgical Review
https://read.qxmd.com/read/38546142/association-of-combined-healthy-lifestyle-with-risk-of-adverse-outcomes-in-patients-with-prediabetes
#3
JOURNAL ARTICLE
Xiaoqin Xu, Jiang Li, Yuefeng Yu, Xiao Tan, Fei Xu, Bin Wang, Ningjian Wang, Yingli Lu
OBJECTIVE: Prediabetes and lifestyle factors have been associated with the risks of multiple adverse outcomes, but the effect of a healthy lifestyle on prediabetes-related complications remains unknown. We aimed to investigate whether the risks of multiple adverse outcomes including incident type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), and chronic kidney disease (CKD) among individuals with prediabetes can be offset by a broad combination of healthy lifestyle factors...
May 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38545970/-advances-in-efficient-biosynthesis-of-erythritol-by-metabolic-engineering-of-yarrowia-lipolytica
#4
JOURNAL ARTICLE
Lianggang Huang, Bowen Xiao, Wenjia Wang, Wen Li, Weihong Zhang, Junping Zhou, Xue Cai, Bo Zhang, Zhiqiang Liu, Yuguo Zheng
Erythritol is a novel 4-carbon sugar alcohol produced by microbes in the presence of hyper-osmotic stress. It has excellent potential to serve as an alternative sugar for people with diabetes and also a platform compound for synthesizing various C4 compounds, such as 1, 3-butadiene, 1, 4-butanediol, 2, 5-dihydrofuran and so on. Compared with other polyols, the fermentative production of erythritol is more challenging. Yarrowia lipolytica is the preferred chassis of erythritol biosynthesis for its high-titer and high-productivity...
March 25, 2024: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://read.qxmd.com/read/38545533/nerve-growth-factor-in-psychiatric-disorders-a-scoping-review
#5
REVIEW
Alankrit Jaiswal, Umesh Shreekantiah, Nishant Goyal
BACKGROUND: Neurotrophins have been implicated in multiple psychiatric disorders. Nerve Growth Factor (NGF) is one of the major neurotrophins that has attracted much research interest. Therefore, we undertook, to the best of our knowledge, the first scoping review encompassing all major psychiatric disorders and their relation to NGF. This review aimed to identify the current position of NGF in psychiatric research and to outline present gaps in knowledge, which can be answered with a more detailed systematic review in the future...
November 2023: Indian Journal of Psychological Medicine
https://read.qxmd.com/read/38544909/targeting-nuclear-receptors-for-nash-mash-from-bench-to-bedside
#6
JOURNAL ARTICLE
Rohit A Sinha
The onset of metabolic dysfunction-associated steatohepatitis (MASH) or non-alcoholic steatohepatitis (NASH) represents a tipping point leading to liver injury and subsequent hepatic complications in the natural progression of what is now termed metabolic dysfunction-associated steatotic liver diseases (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD). With no pharmacological treatment currently available for MASH/NASH, the race is on to develop drugs targeting multiple facets of hepatic metabolism, inflammation, and pro-fibrotic events, which are major drivers of MASH...
March 2024: Liver Research
https://read.qxmd.com/read/38544766/etiological-spectrum-of-cirrhosis-in-india-a%C3%A2-systematic-review-and-meta-analysis
#7
JOURNAL ARTICLE
Shekhar Swaroop, Manas Vaishnav, Umang Arora, Sagnik Biswas, Arnav Aggarwal, Soumya Sarkar, Puneet Khanna, Anshuman Elhence, Ramesh Kumar, Amit Goel, Shalimar
BACKGROUND: Cirrhosis is a significant cause of morbidity and mortality globally and in India. This systematic review and meta-analysis aimed to ascertain the etiological spectrum and changing trends of cirrhosis in India. METHODS: We searched electronic databases, including Pubmed/Medline, Scopus, and Embase. We included original studies that reported the etiology of cirrhosis in the Indian population. RESULTS: We included 158 studies (adults: 147, children: 11)...
2024: Journal of Clinical and Experimental Hepatology
https://read.qxmd.com/read/38543617/vancomycin-resistant-streptococcus-thoraltensis-a-case-report-of-bacterial-endocarditis-and-review-of-literature-on-infections-caused-by-this-pathogen
#8
REVIEW
Roxana Mihaela Chiorescu, Sandor Botond Buksa, Alexandru Botan, Mihaela Mocan, Carmen Costache, Dan Alexandru Toc
Streptococcus thoraltensis is a rare species, part of the viridans streptococcus group, found initially in rabbits and pigs, which can be vancomycin-resistant. We present the case of a 65-year-old patient, a smoker and chronic alcohol consumer with chronic obstructive pulmonary disease (COPD) and multiple dental foci who had been diagnosed with bacterial endocarditis caused by Streptococcus thoraltensis . The particular elements of the case consisted of an atypical clinical presentation with diarrheal stools, abdominal pain, concomitant damage to the aortic and tricuspid valves, the presence of large vegetations (>2 cm), and a vancomycin-resistant strain of Streptococcus thoraltensis ...
March 12, 2024: Microorganisms
https://read.qxmd.com/read/38542712/healthy-lifestyle-and-cancer-risk-modifiable-risk-factors-to-prevent-cancer
#9
REVIEW
Pasquale Marino, Mariangela Mininni, Giovanni Deiana, Graziella Marino, Rosa Divella, Ilaria Bochicchio, Alda Giuliano, Stefania Lapadula, Alessandro Rocco Lettini, Francesca Sanseverino
Cancer has become a serious problem worldwide, as it represents the main cause of death, and its incidence has increased over the years. A potential strategy to counter the growing spread of various forms of cancer is the adoption of prevention strategies, in particular, the use of healthy lifestyles, such as maintaining a healthy weight, following a healthy diet; being physically active; avoiding smoking, alcohol consumption, and sun exposure; and vitamin D supplementation. These modifiable risk factors are associated with this disease, contributing to its development, progression, and severity...
March 11, 2024: Nutrients
https://read.qxmd.com/read/38542255/environmental-pollution-and-risk-of-childhood-cancer-a-scoping-review-of-evidence-from-the-last-decade
#10
REVIEW
María Del Pilar Navarrete-Meneses, Consuelo Salas-Labadía, Fernando Gómez-Chávez, Patricia Pérez-Vera
The long-term effects of environmental pollution have been of concern as several pollutants are carcinogenic, potentially inducing a variety of cancers, including childhood cancer, which is a leading cause of death around the world and, thus, is a public health issue. The present scoping review aimed to update and summarize the available literature to detect specific environmental pollutants and their association with certain types of childhood cancer. Studies published from 2013 to 2023 regarding environmental pollution and childhood cancer were retrieved from the PubMed database...
March 14, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542249/inflammatory-bowel-diseases-and-non-alcoholic-fatty-liver-disease-piecing-a-complex-puzzle-together
#11
REVIEW
Rossella Maresca, Irene Mignini, Simone Varca, Valentin Calvez, Fabrizio Termite, Giorgio Esposto, Lucrezia Laterza, Franco Scaldaferri, Maria Elena Ainora, Antonio Gasbarrini, Maria Assunta Zocco
Inflammatory bowel diseases (IBD), comprising Crohn's disease and ulcerative colitis, are systemic and multifaceted disorders which affect other organs in addition to the gastrointestinal tract in up to 50% of cases. Extraintestinal manifestations may present before or after IBD diagnosis and negatively impact the intestinal disease course and patients' quality of life, often requiring additional diagnostic evaluations or specific treatments. Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide...
March 14, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541637/influence-of-alcohol-on-intracerebral-hemorrhage-from-oxidative-stress-to-glial-cell-activation
#12
REVIEW
Shaik Ismail Mohammed Thangameeran, Po-Kai Wang, Hock-Kean Liew, Cheng-Yoong Pang
The intricate relationship between alcohol consumption and intracerebral hemorrhage (ICH) presents a nuanced field of study, especially concerning the dose-dependent impact on secondary brain injury (SBI). Recognizing the established risks associated with heavy drinking, this review delves deeper into the less understood territories of low to moderate alcohol consumption. By systematically analyzing recent studies, we uncover critical insights into how varying alcohol intake levels modulate ICH risk through mechanisms such as microglial activation, oxidative stress, and the protective potential of polyphenols...
February 27, 2024: Life
https://read.qxmd.com/read/38541344/preconception-health-of-indigenous-peoples-in-australia-canada-new-zealand-and-the-united-states-a-scoping-review
#13
REVIEW
Clara Walker, Tahmina Begum, Jacqueline A Boyle, James Ward, Federica Barzi
BACKGROUND: There is increasing recognition of the importance of the preconception period for addressing reproductive and intergenerational health inequities and supporting improved maternal and child health outcomes. This study aimed to understand the extent and type of evidence that exists in relation to preconception health for Indigenous peoples living in high-income countries with similar experiences of colonisation, namely, Australia, New Zealand, Canada, and the United States. METHODS: This review was conducted as per the JBI methodology and PRISMA Extension for Scoping Reviews...
March 14, 2024: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/38541229/updated-perspectives-on-lifestyle-interventions-as-secondary-stroke-prevention-measures-a-narrative-review
#14
REVIEW
Valbona Govori, Hrvoje Budinčević, Sandra Morović, Filip Đerke, Vida Demarin
Despite being highly preventable, stroke is the second-most common cause of death and disability in the world. Secondary prevention is critical as the stroke recurrence risk is 6- to 15-fold higher than the risk of stroke in the general population. Stroke recurrence is associated with higher mortality rates and increased disability levels. Lifestyle modifications should address not single but multiple cardiovascular risk factors to effectively reduce the risk of stroke. Lifestyle modifications on a personal level should include adequate physical activity, a healthy diet, the cessation of smoking and alcohol consumption, and stress reduction...
March 19, 2024: Medicina
https://read.qxmd.com/read/38541138/evolution-of-liver-transplantation-indications-expanding-horizons
#15
REVIEW
Sara Battistella, Marco Grasso, Elisa Catanzaro, Francesca D'Arcangelo, Giorgia Corrà, Giacomo Germani, Marco Senzolo, Alberto Zanetto, Alberto Ferrarese, Martina Gambato, Patrizia Burra, Francesco Paolo Russo
Liver transplantation (LT) has significantly transformed the prognosis of patients with end-stage liver disease and hepatocellular carcinoma (HCC). The traditional epidemiology of liver diseases has undergone a remarkable shift in indications for LT, marked by a decline in viral hepatitis and an increase in metabolic dysfunction-associated steatotic liver disease (MASLD), along with expanded indications for HCC. Recent advancements in surgical techniques, organ preservation and post-transplant patients' management have opened new possibilities for LT...
February 28, 2024: Medicina
https://read.qxmd.com/read/38540294/macroscopic-and-microscopic-cerebral-findings-in-drug-and-alcohol-abusers-the-point-of-view-of-the-forensic-pathologist
#16
REVIEW
Angelo Montana, Letizia Alfieri, Margherita Neri, Denise Piano, Eva Renier, Matteo Marti, Marco Palpacelli, Giuseppe Basile, Giovanni Tossetta, Francesco Paolo Busardò
Drug abuse still represents a significant challenge for forensic pathologists; it must always be considered during the autopsy examination when the brain morphological alterations observed are not characteristic of any known disease of the central nervous system (CNS). Nonetheless, no specific brain lesions had been found to characterize the precise drug that caused the poisoning. In fact, a broad spectrum of changes affecting the CNS are seen in drug abusers. Thus, forensic pathology plays a key role in identifying the encephalic morphological alterations underlying the death...
March 19, 2024: Biomedicines
https://read.qxmd.com/read/38540277/unraveling-the-role-of-endothelial-dysfunction-in-osteonecrosis-of-the-femoral-head-a-pathway-to-new-therapies
#17
REVIEW
Wenkai Shao, Ping Wang, Xiao Lv, Bo Wang, Song Gong, Yong Feng
Osteonecrosis of the femoral head (ONFH) is a disabling disease characterized by the disruption of the blood supply to the femoral head, leading to the apoptosis and necrosis of bone cells and subsequent joint collapse. Total hip arthroplasty is not optimal since most patients are young. Multiple risk factors contribute to osteonecrosis, including glucocorticoid (GC) usage, excessive alcohol intake, hypercholesterolemia, and smoking. Continuous stimulation by many variables causes a chronic inflammatory milieu, with clinical repercussions including endothelial dysfunction, leading to thrombosis, coagulopathy, and poor angiogenesis...
March 15, 2024: Biomedicines
https://read.qxmd.com/read/38540163/double-trouble-how-microbiome-dysbiosis-and-mitochondrial-dysfunction-drive-non-alcoholic-fatty-liver-disease-and-non-alcoholic-steatohepatitis
#18
REVIEW
Wesam Bahitham, Siraj Alghamdi, Ibrahim Omer, Ali Alsudais, Ilana Hakeem, Arwa Alghamdi, Reema Abualnaja, Faisal M Sanai, Alexandre S Rosado, Consolato M Sergi
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are closely related liver conditions that have become more prevalent globally. This review examines the intricate interplay between microbiome dysbiosis and mitochondrial dysfunction in the development of NAFLD and NASH. The combination of these two factors creates a synergistic situation referred to as "double trouble", which promotes the accumulation of lipids in the liver and the subsequent progression from simple steatosis (NAFLD) to inflammation (NASH)...
February 29, 2024: Biomedicines
https://read.qxmd.com/read/38540128/updated-insights-into-probiotics-and-hepatobiliary-diseases
#19
REVIEW
Xiaoyu Xu, Cheng Zhang, Guoyi Tang, Ning Wang, Yibin Feng
Hepatobiliary diseases have a high prevalence worldwide, with a wide range of diseases involved in the liver and biliary system. Modifications in gut microbiota have been proven to have an association with unbalanced intestinal homeostasis and the dysfunction of host metabolism and the immune system, which can be the risk factors for many hepatobiliary diseases, such as nonalcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), nonalcoholic fatty steatohepatitis (NASH), hepatitis, cirrhosis, hepatocellular carcinoma (HCC) and cholestasis, as well as infection due to liver transplantation...
February 25, 2024: Biomedicines
https://read.qxmd.com/read/38540110/novel-interventions-on-comorbidities-in-patients-with-fetal-alcohol-spectrum-disorder-fasd-an-integrative-review
#20
REVIEW
Vicente Andreu-Fernández, Nunzia La Maida, Maribel Marquina, Afrouz Mirahi, Oscar García-Algar, Simona Pichini, Adele Minutillo
Prenatal exposure to alcohol can cause Fetal Alcohol Spectrum Disorders (FASDs) after birth, encompassing a spectrum of physical, cognitive, and behavioral abnormalities. FASD represents a severe non-genetic disability avoidable through alcohol abstinence during pregnancy and when planning it. Clinical severity depends on alcohol impact, symptomatology, and resulting disabilities. FASD is a permanent disability with no recognized specific medical care. Conversely, secondary FASD-related disabilities can be symptomatically treated...
February 22, 2024: Biomedicines
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