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https://www.readbyqxmd.com/read/28634412/extracellular-vesicles-in-liver-disease-and-potential-as-biomarkers-and-therapeutic-targets
#1
REVIEW
Gyongyi Szabo, Fatemeh Momen-Heravi
Extracellular vesicles (EVs) are membranous vesicles originating from different cells in the liver. The pathophysiological role of EVs is increasingly recognized in liver diseases, including alcoholic liver disease, NAFLD, viral hepatitis and hepatocellular carcinoma. EVs, via their cargo, can provide communication between different cell types in the liver and between organs. EVs are explored as biomarkers of disease and could also represent therapeutic targets and vehicles for treatment delivery. Here, we review advances in understanding the role of EVs in liver diseases and discuss their utility in biomarker discovery and therapeutics...
June 21, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28632074/isopropyl-alcohol-swabs-as-a-preferred-substance-of-abuse
#2
Aditi Sharma, Jonathan D Morrow
The authors describe the treatment of a 36-year-old woman who presented with excessive consumption of antiseptic alcohol swabs. Her behavior was diagnosed as a severe substance use disorder with isopropyl alcohol as the primary drug of choice. Diagnostic and treatment challenges involved in the case are discussed in detail, with particular focus on the differential diagnosis for this unusual presentation, including obsessive compulsive disorder, pica, and intentional self-injurious behavior. A brief review of the literature on non-ethanol ingestion for the purposes of intoxication is included, as well as clinical information about the potential dangers posed by isopropyl alcohol consumption...
February 26, 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/28631875/nursing-assessment-as-an-effective-tool-for-the-identification-of-delirium-risk-in-older-in-patients-a-case-control-study
#3
Elena Solà-Miravete, Carlos López, Estrella Martínez-Segura, Mireia Adell-Lleixà, Maria Eulàlia Juvé-Udina, Mar Lleixà-Fortuño
AIMS: To evaluate the usefulness of comprehensive nursing assessment as a strategy for determining the risk of delirium in older in-patients from a model of care needs based on variables easily measured by nurses. BACKGROUND: There are many scales of assessment and prediction of risk of delirium, but they are little known and infrequently used by professionals. Recognition of delirium by doctors and nurses continues to be limited. DESIGN AND METHODS: A case-control study...
June 20, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28629470/policy-lessons-from-health-taxes-a-systematic-review-of-empirical-studies
#4
Alexandra Wright, Katherine E Smith, Mark Hellowell
BACKGROUND: Taxes on alcohol and tobacco have long been an important means of raising revenues for public spending in many countries but there is increasing interest in using taxes on these, and other unhealthy products, to achieve public health goals. We present a systematic review of the research on health taxes, and aim to generate insights into how such taxes can: (i) reduce consumption of targeted products and related harms; (ii) generate revenues for health objectives and distribute the tax burden across income groups in an efficient and equitable manner; and (iii) be made politically sustainable...
June 19, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28629185/leptadenia-reticulata-retz-wight-arn-jivanti-botanical-agronomical-phytochemical-pharmacological-and-biotechnological-aspects
#5
REVIEW
Sudipta Kumar Mohanty, Mallappa Kumara Swamy, Uma Rani Sinniah, Maniyam Anuradha
Leptadenia reticulata (Retz.) Wight & Arn. (Apocynaceae), is a traditional medicinal plant species widely used to treat various ailments such as tuberculosis, hematopoiesis, emaciation, cough, dyspnea, fever, burning sensation, night blindness, cancer, and dysentery. In Ayurveda, it is known for its revitalizing, rejuvenating, and lactogenic properties. This plant is one of the major ingredients in many commercial herbal formulations, including Speman, Envirocare, Calshakti, Antisept, and Chyawanprash. The therapeutic potential of this herb is because of the presence of diverse bioactive compounds such as α-amyrin, β-amyrin, ferulic acid, luteolin, diosmetin, rutin, β-sitosterol, stigmasterol, hentricontanol, a triterpene alcohol simiarenol, apigenin, reticulin, deniculatin, and leptaculatin...
June 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28629152/the-association-between-pediatric-nafld-and-common-genetic-variants
#6
REVIEW
Giuseppina Rosaria Umano, Mariangela Martino, Nicola Santoro
Non-alcoholic fatty liver disease (NAFLD) is one of the most common complications of obesity. Several studies have shown that genetic predisposition probably plays an important role in its pathogenesis. In fact, in the last few years a large number of genetic studies have provided compelling evidence that some gene variants, especially those in genes encoding proteins regulating lipid metabolism, are associated with intra-hepatic fat accumulation. Here we provide a comprehensive review of the gene variants that have affected the natural history of the disease...
June 18, 2017: Children
https://www.readbyqxmd.com/read/28628497/predicting-short-term-and-long-term-mortality-of-hospitalized-portuguese-patients-with-alcoholic-hepatitis
#7
Samuel R Fernandes, Pedro Marques da Costa, Sofia Vítor, Joana R Carvalho, Patrícia Santos, Carlos M Moura, Helena Cortez-Pinto, Fernando Ramalho, José Velosa
BACKGROUND: Alcohol abuse can result in a spectrum of liver injury that ranges from mild fatty infiltration to alcoholic hepatitis (AH), cirrhosis, and hepatocellular carcinoma. The present study aimed to evaluate current scoring systems in predicting short-term and long-term mortality because of AH. PATIENTS AND METHODS: Records of 170 consecutive patients with AH admitted to a tertiary center between January 2005 and October 2015 were reviewed. Clinical and biochemical parameters were retrieved for the assessment of AH scores for the day of admission (D1) and for the seventh day of hospitalization (D7)...
June 16, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28628397/culturally-informed-interventions-for-substance-abuse-among-indigenous-youth-in-the-united-states-a-review
#8
Jessica Liddell, Catherine E Burnette
PURPOSE: Given the disproportionately high levels of alcohol and other drug abuse among Indigenous youth in the United States, the purpose of this systematic review was to explicate the current state of empirically-based and culturally-informed substance abuse prevention and intervention programs for Indigenous youth (ages 9-18). METHOD: The 14 articles that met inclusion criteria for this review were analyzed both in terms of the cultural intervention itself (primary population, intervention, core tenants, focus of intervention, intervention goals, location, intervention location, and program length) and their evaluation approach...
June 19, 2017: Journal of Evidence-informed Social Work
https://www.readbyqxmd.com/read/28627645/therapeutic-strategies-for-alcoholic-liver-disease-focusing-on-inflammation-and-fibrosis-review
#9
Hideto Kawaratani, Kei Moriya, Tadashi Namisaki, Masakazu Uejima, Mitsuteru Kitade, Kousuke Takeda, Yasushi Okura, Kousuke Kaji, Hiroaki Takaya, Norihisa Nishimura, Shinya Sato, Yasuhiko Sawada, Kenichiro Seki, Takuya Kubo, Akira Mitoro, Junichi Yamao, Hitoshi Yoshiji
Excessive alcohol consumption is the most common cause of liver disease in the world. Chronic alcohol abuse leads to liver damage, liver inflammation, fibrosis and hepatocellular carcinoma. Inflammatory cytokines, such as tumor necrosis factor-α and interferon-γ, induce liver injury, which leads to the develo-pment of alcoholic liver disease (ALD). Hepatoprotective cytokines, such as interleukin (IL)-6 and IL-10, are also associated with ALD. IL-6 improves ALD via the activation of STAT3 and the subsequent induction of a variety of hepatoprotective genes in hepatocytes...
June 9, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28627170/role-of-the-nozaki-hiyama-takai-kishi-reaction-in-the-synthesis-of-natural-products
#10
Alejandro Gil, Fernando Albericio, Mercedes Álvarez
The Nozaki-Hiyama-Takai-Kishi (NHTK) reaction was discovered in the late 1970s and, since then, its main application has been its use in total synthesis. In this comprehensive review, the efficiency of the NHKT reaction in the synthesis of a great number of different scaffolds present in complex natural products is analyzed. The preparation of enol and allylic and propargylic alcohol motifs is discussed, highlighting factors such as yield, chemoselectivity, stereoselectivity, or the importance of protecting groups...
June 19, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28624588/segmented-regression-analysis-of-interrupted-time-series-data-to-assess-outcomes-of-a-south-american-road-traffic-alcohol-policy-change
#11
Beatriz Nistal-Nuño
BACKGROUND: In Chile, a new law introduced in March 2012 decreased the legal blood alcohol concentration (BAC) limit for driving while impaired from 1 to 0.8 g/l and the legal BAC limit for driving under the influence of alcohol from 0.5 to 0.3 g/l. The goal is to assess the impact of this new law on mortality and morbidity outcomes in Chile. METHODS: A review of national databases in Chile was conducted from January 2003 to December 2014. Segmented regression analysis of interrupted time series was used for analyzing the data...
June 14, 2017: Public Health
https://www.readbyqxmd.com/read/28624587/the-lateral-habenula-and-alcohol-role-of-glutamate-and-m-type-potassium-channels
#12
REVIEW
Avi Shah, Wanhong Zuo, Seungwoo Kang, Jing Li, Rao Fu, Haifeng Zhang, Alex Bekker, Jiang-Hong Ye
Alcohol use disorder (AUD) or alcoholism is a chronic relapsing disorder. Our knowledge of alcoholism hinges on our understanding of its effects on the brain. This review will center on the effects of alcohol in the lateral habenula (LHb), an epithalamic structure that connects the forebrain with the midbrain and encodes aversive signaling. Like many addictive drugs, alcohol has both rewarding and aversive properties. While alcohol's euphoric property is believed to be important for the initiation of drinking, increasing evidence suggests that alcohol's negative affect plays a critical role in excessive drinking and alcohol dependence...
June 14, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28624106/alcohol-use-and-smoking-after-liver-transplantation-complications-and-prevention
#13
REVIEW
José Ursic-Bedoya, Hélène Donnadieu-Rigole, Stéphanie Faure, Georges-Philippe Pageaux
The last thirty years have been very prosperous in the field of liver transplantation (LT), with great advances in organ conservation, surgical techniques, peri-operative management and long-term immunosuppression, resulting in improved patient and graft survival rates as well as quality of life. However, substance addiction after LT, namely alcohol and tobacco, results in short term morbidity together with medium and long-term mortality. The main consequences can be vascular (increased risk of hepatic artery thrombosis in smokers), hepatic (recurrent alcoholic cirrhosis in alcohol relapsers) and oncological (increased risk of malignancy in patients consuming tobacco and/or alcohol after LT)...
April 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/28622887/genetic-etiology-of-oral-cancer
#14
REVIEW
Johar Ali, Bibi Sabiha, Hanif Ullah Jan, Syed Adnan Haider, Abid Ali Khan, Saima S Ali
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. It accounts for 2.5% of all new cancer cases and 1.9% of all cancer deaths annually. More than 90% of oral cancers (occurring in the mouth, lip, and tongue) are oral squamous cell carcinoma. The incidence rate of oral cancer varies widely throughout the world, with an evident prevalence in South Asian countries. This high incidence occurs in correlation with oral cancer-associated behaviors such as alcohol, tobacco use...
July 2017: Oral Oncology
https://www.readbyqxmd.com/read/28622592/second-generation-h1-antihistamines-interaction-with-food-and-alcohol-a-systematic-review
#15
REVIEW
Paweł Paśko, Tomasz Rodacki, Renata Domagała-Rodacka, Krzysztof Palimonka, Monika Marcinkowska, Danuta Owczarek
Histamine is a mediator of many physiological processes. It plays an important role in modulating allergy reactions and immune system responses. H1 receptor is a therapeutic target for drugs applied in allergic diseases such as allergic rhinoconjunctivitis, urticarial, or atopic dermatitis. H1-antihistamines display different chemical structures, pharmacokinetics and a potential for drug-drug and drug-food interactions. Drug-food interactions are known to reduce therapeutic effects of the medicine, as well as to induce a potent adverse drug reactions...
June 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28619078/psychological-interventions-for-the-treatment-of-depression-anxiety-alcohol-misuse-or-anger-in-armed-forces-veterans-and-their-families-systematic-review-and-meta-analysis-protocol
#16
Luke O'Shea, Ed Watkins, Paul Farrand
BACKGROUND: Evidence highlights a high prevalence of common mental health disorders in armed forces veterans and their families, with depression, anxiety, alcohol misuse and anger being more common than PTSD. This paper presents a protocol for a systematic review and meta-analysis to identify existing randomised controlled trial (RCT) research testing the effectiveness of psychological interventions for these difficulties in armed forces veterans and their family members. METHODS: Electronic databases (CENTRAL, PsycInfo, MEDLINE, CINAHL, The Cochrane Register of Clinical Trials, EMBASE and ASSIA) will be searched to identify suitable studies for inclusion in the review supplemented by forward and backward reference checking, grey literature searches and contact with subject authors...
June 15, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28619031/healthy-people-and-healthy-profits-elaborating-a-conceptual-framework-for-governing-the-commercial-determinants-of-non-communicable-diseases-and-identifying-options-for-reducing-risk-exposure
#17
REVIEW
Kent Buse, Sonja Tanaka, Sarah Hawkes
BACKGROUND: Non-communicable diseases (NCDs) represent a significant threat to human health and well-being, and carry significant implications for economic development and health care and other costs for governments and business, families and individuals. Risks for many of the major NCDs are associated with the production, marketing and consumption of commercially produced food and drink, particularly those containing sugar, salt and transfats (in ultra-processed products), alcohol and tobacco...
June 15, 2017: Globalization and Health
https://www.readbyqxmd.com/read/28618018/executive-functions-memory-and-social-cognitive-deficits-and-recovery-in-chronic-alcoholism-a-critical-review-to-inform-future-research
#18
Anne-Pascale Le Berre, Rosemary Fama, Edith V Sullivan
Alcoholism is a complex and dynamic disease, punctuated by periods of abstinence and relapse, and influenced by a multitude of vulnerability factors. Chronic excessive alcohol consumption is associated with cognitive deficits, ranging from mild to severe, in executive functions, memory, and metacognitive abilities, with associated impairment in emotional processes and social cognition. These deficits can compromise efforts in initiating and sustaining abstinence by hampering efficacy of clinical treatment and can obstruct efforts in enabling good decision-making, success in interpersonal/social interactions, and awareness of cognitive and behavioral dysfunctions...
June 15, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28616440/cardiomyopathy-related-to-a-weight-loss-supplement-a-case-report-and-review-of-literature
#19
Ghulam Murtaza, Sujeen Adhikari, Irfan Siddiqui, Hannah Lu, Aneesh Kuruvilla
There are various etiologies of dilated cardiomyopathy. However, in young patients without a strong family history of cardiovascular disease, alcohol or drug abuse, viral infections, and absence of endocrine and metabolic abnormalities, ischemia is an unlikely cause. We present an interesting case of a young female without traditional risk factors who developed dilated cardiomyopathy following administration of a weight loss supplement xenadrine and had resolution of symptoms after discontinuation of the supplement...
April 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28615983/legionnaires-disease-clinicoradiological-comparison-of-sporadic-versus-outbreak-cases
#20
Hafiz Rizwan Talib Hashmi, Lakshmi Saladi, Frances Petersen, Misbahuddin Khaja, Gilda Diaz-Fuentes
BACKGROUND: In 2015, New York City experienced the worst outbreak of Legionnaires' disease in the history of the city. We compare patients seen during the 2015 outbreak with sporadic cases of Legionella during the past 5 years. METHODS: We conducted a retrospective chart review of 90 patients with Legionnaires' disease, including sporadic cases of Legionella infection admitted from 2010 to 2015 (n = 55) and cases admitted during the 2015 outbreak (n = 35). RESULTS: We saw no significant differences between the 2 groups regarding demographics, smoking habits, alcohol intake, underlying medical disease, or residence type...
2017: Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine
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