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https://www.readbyqxmd.com/read/27864146/microrna-187-regulates-gastric-cancer-progression-by-targeting-the-tumor-suppressor-crmp1
#1
Lian Ren, Fang Li, Maojun Di, Yingfeng Fu, Yuanjian Hui, Gaochun Xiao, Qiang Sun, Yanwei Liu, Dan Ren, Xian Du
Aberrant expression of microRNAs contributes to the initiation and progression of numerous human cancers. The underlying effects and molecular mechanisms of microRNA-187 (miR-187) in gastric cancer (GC) remain unclear. The present study reports that miR-187 was significantly overexpressed in GC tissues compared to that in non-tumor tissues and was associated with malignant clinical factors such as depth of invasion (P = 0.005), tumor size (P = 0.024), lymph node metastasis (P = 0.048), and TNM stage (P = 0...
November 15, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27836492/crmp1-and-crmp4-are-required-for-proper-orientation-of-dendrites-of-cerebral-pyramidal-neurons-in-the-developing-mouse-brain
#2
Ryosuke Takaya, Jun Nagai, Wenfui Piao, Emi Niisato, Takeru Nakabayashi, Yuki Yamazaki, Fumio Nakamura, Naoya Yamashita, Papachan Kolattukudy, Yoshio Goshima, Toshio Ohshima
Neural circuit formation is a critical process in brain development. Axon guidance molecules, their receptors, and intracellular mediators are important to establish neural circuits. Collapsin response mediator proteins (CRMPs) are known intercellular mediators of a number of repulsive guidance molecules. Studies of mutant mice suggest roles of CRMPs in dendrite development. However, molecular mechanisms of CRMP-mediated dendritic development remain to elucidate. In this study, we show abnormal orientation of basal dendrites (extension to deeper side) of layer V pyramidal neurons in the cerebral cortex of CRMP4-/- mice...
November 8, 2016: Brain Research
https://www.readbyqxmd.com/read/27665090/subtelomeric-copy-number-variations-the-importance-of-4p-4q-deletions-in-patients-with-congenital-anomalies-and-developmental-disability
#3
Gil M Novo-Filho, Marília M Montenegro, Évelin A Zanardo, Roberta L Dutra, Alexandre T Dias, Flavia B Piazzon, Taís V M M Costa, Amom M Nascimento, Rachel S Honjo, Chong A Kim, Leslie D Kulikowski
The most prevalent structural variations in the human genome are copy number variations (CNVs), which appear predominantly in the subtelomeric regions. Variable sizes of 4p/4q CNVs have been associated with several different psychiatric findings and developmental disability (DD). We analyzed 105 patients with congenital anomalies (CA) and developmental and/or intellectual disabilities (DD/ID) using MLPA subtelomeric specific kits (P036 /P070) and 4 of them using microarrays. We found abnormal subtelomeric CNVs in 15 patients (14...
September 24, 2016: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/27475326/collapsin-response-mediator-protein-4-isoforms-crmp4a-and-crmp4b-have-opposite-effects-on-cell-proliferation-migration-and-invasion-in-gastric-cancer
#4
Haijian Guo, Bing Xia
BACKGROUND: Collapsin response mediator proteins (CRMPs) were originally identified in the nervous system and are involved in neuronal development. Similar to CRMP1, CRMP4 has a shorter transcript encoding a short isoform known as CRMP4a, and a longer transcript encoding a long isoform known as CRMP4b. Previous studies have shown that CRMP4a and CRMP4b exhibit opposing functions in neurite outgrowth. In the present study, we aimed to determine whether CRMP4a and CRMP4b have divergent effects in gastric cancer...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27456940/underexpression-of-hoxa11-is-associated-with-treatment-resistance-and-poor-prognosis-in-glioblastoma
#5
Young-Bem Se, Seung Hyun Kim, Ji Young Kim, Ja Eun Kim, Yun-Sik Dho, Jin Wook Kim, Yong Hwy Kim, Hyun Goo Woo, Se-Hyuk Kim, Shin-Hyuk Kang, Hak Jae Kim, Tae Min Kim, Soon-Tae Lee, Seung Hong Choi, Sung-Hye Park, Il Han Kim, Dong Gyu Kim, Chul-Kee Park
Purpose: Homeobox (HOX) genes are essential developmental regulators that should normally be in the silenced state in an adult brain. The aberrant expression of HOX genes has been associated with the prognosis of many cancer types, including glioblastoma (GBM). This study examined the identity and role of HOX genes affecting GBM prognosis and treatment resistance. Materials and Methods: The full series of HOX genes of 5 pairs of initial and recurrent human GBM samples were screened by microarray analysis to determine the most plausible candidate responsible for GBM prognosis...
July 19, 2016: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/27446404/early-detection-of-tumor-relapse-regrowth-by-consecutive-minimal-residual-disease-monitoring-in-high-risk-neuroblastoma-patients
#6
Satoshi Hirase, Atsuro Saitoh, Tri Budi Hartomo, Aiko Kozaki, Tomoko Yanai, Daiichiro Hasegawa, Keiichiro Kawasaki, Yoshiyuki Kosaka, Masafumi Matsuo, Nobuyuki Yamamoto, Takeshi Mori, Akira Hayakawa, Kazumoto Iijima, Hisahide Nishio, Noriyuki Nishimura
Neuroblastoma is an aggressive pediatric tumor accounting for ~15% of cancer-associated mortalities in children. Despite the current intensive therapy, >50% of high-risk patients experience tumor relapse or regrowth caused by the activation of minimal residual disease (MRD). Although several MRD detection protocols using various reverse transcription-quantitative polymerase chain reaction (RT-qPCR) markers have been reported to evaluate the therapeutic response and disease status of neuroblastoma patients, their clinical significance remains elusive...
August 2016: Oncology Letters
https://www.readbyqxmd.com/read/27321179/collapsin-response-mediator-protein-1-crmp1-acts-as-an-invasion-and-metastasis-suppressor-of-prostate-cancer-via-its-suppression-of-epithelial-mesenchymal-transition-and-remodeling-of-actin-cytoskeleton-organization
#7
G Cai, D Wu, Z Wang, Z Xu, K-B Wong, C-F Ng, F L Chan, S Yu
The cancer cells can acquire migration and invasion capacities during the metastasis process through the developmental regulatory program epithelial-mesenchymal-transition (EMT), and through its reverse process mesenchymal-epithelial transition cancer cells can recolonize at distant metastatic sites. Among the multifaceted effects exerted by this program, reorganization of actin cytoskeleton is the key mechanical drive for the invasive properties gained by cancer cells. Collapsin response mediator protein-1 (CRMP1) is a cytosolic phosphoprotein and originally characterized as the mediator of semaphorin 3A signaling involved in axon differentiation during neural development...
June 20, 2016: Oncogene
https://www.readbyqxmd.com/read/26722317/differential-expression-of-minimal-residual-disease-markers-in-peripheral-blood-and-bone-marrow-samples-from-high-risk-neuroblastoma-patients
#8
Nobuyuki Yamamoto, Aiko Kozaki, Tri Budi Hartomo, Tomoko Yanai, Daiichiro Hasegawa, Keiichiro Kawasaki, Yoshiyuki Kosaka, Masafumi Matsuo, Satoshi Hirase, Takeshi Mori, Akira Hayakawa, Kazumoto Iijima, Hisahide Nishio, Noriyuki Nishimura
Neuroblastoma is an aggressive solid tumor that leads to tumor relapse in more than half of high-risk patients. Minimal residual disease (MRD) is primarily responsible for tumor relapses and may be detected in peripheral blood (PB) and bone marrow (BM) samples. To evaluate the disease status and treatment response, a number of MRD detection protocols based on either common or distinct markers for PB and BM samples have been reported. However, the correlation between the expression of MRD markers in PB and BM samples remains elusive in the clinical samples...
November 2015: Oncology Letters
https://www.readbyqxmd.com/read/26009886/crmp1-inhibits-proliferation-of-medulloblastoma-and-is-regulated-by-hmga1
#9
Kay Ka-Wai Li, Yan Qi, Tian Xia, Yu Yao, Liangfu Zhou, Kin-Mang Lau, Ho-Keung Ng
Many facets of the tumor biology of medulloblastoma (MB) have not been fully elucidated. Collapsin response mediator protein 1 (CRMP1) is a member of cytoplasmic family of proteins that regulate the development of central nervous system. Recent studies demonstrated that CRMP1 could function as an invasion suppressor. We reported previously that high mobility group AT-hook 1 (HMGA1) contributed to development of MB and regulated its growth and migration/invasion. Transcriptional profiling and quantitative RT-PCR revealed increased expression of CRMP1 in HMGA1-depleted cells, suggesting that CRMP1 may be a downstream target of HMGA1 in MB...
2015: PloS One
https://www.readbyqxmd.com/read/25908449/systematic-interaction-network-filtering-identifies-crmp1-as-a-novel-suppressor-of-huntingtin-misfolding-and-neurotoxicity
#10
Martin Stroedicke, Yacine Bounab, Nadine Strempel, Konrad Klockmeier, Sargon Yigit, Ralf P Friedrich, Gautam Chaurasia, Shuang Li, Franziska Hesse, Sean-Patrick Riechers, Jenny Russ, Cecilia Nicoletti, Annett Boeddrich, Thomas Wiglenda, Christian Haenig, Sigrid Schnoegl, David Fournier, Rona K Graham, Michael R Hayden, Stephan Sigrist, Gillian P Bates, Josef Priller, Miguel A Andrade-Navarro, Matthias E Futschik, Erich E Wanker
Assemblies of huntingtin (HTT) fragments with expanded polyglutamine (polyQ) tracts are a pathological hallmark of Huntington's disease (HD). The molecular mechanisms by which these structures are formed and cause neuronal dysfunction and toxicity are poorly understood. Here, we utilized available gene expression data sets of selected brain regions of HD patients and controls for systematic interaction network filtering in order to predict disease-relevant, brain region-specific HTT interaction partners. Starting from a large protein-protein interaction (PPI) data set, a step-by-step computational filtering strategy facilitated the generation of a focused PPI network that directly or indirectly connects 13 proteins potentially dysregulated in HD with the disease protein HTT...
May 2015: Genome Research
https://www.readbyqxmd.com/read/25865307/proteomic-analysis-of-the-palmitoyl-protein-thioesterase-1-interactome-in-sh-sy5y-human-neuroblastoma-cells
#11
Enzo Scifo, Agnieszka Szwajda, Rabah Soliymani, Francesco Pezzini, Marzia Bianchi, Arvydas Dapkunas, Janusz Dębski, Kristiina Uusi-Rauva, Michał Dadlez, Anne-Claude Gingras, Jaana Tyynelä, Alessandro Simonati, Anu Jalanko, Marc H Baumann, Maciej Lalowski
UNLABELLED: Neuronal ceroid lipofuscinoses (NCL) are a group of inherited progressive childhood disorders, characterized by early accumulation of autofluorescent storage material in lysosomes of neurons or other cells. Clinical symptoms of NCL include: progressive loss of vision, mental and motor deterioration, epileptic seizures and premature death. CLN1 disease (MIM#256730) is caused by mutations in the CLN1 gene, which encodes palmitoyl protein thioesterase 1 (PPT1). In this study, we utilised single step affinity purification coupled to mass spectrometry (AP-MS) to unravel the in vivo substrates of human PPT1 in the brain neuronal cells...
June 18, 2015: Journal of Proteomics
https://www.readbyqxmd.com/read/25599124/immunohistochemistry-based-prognostic-biomarkers-in-nsclc-novel-findings-on-the-road-to-clinical-use
#12
REVIEW
Cecilia Lindskog, Karolina Edlund, Johanna Sofia Margareta Mattsson, Patrick Micke
Prognostication of non-small cell lung cancer is principally based on stage, age and performance status. This review provides an overview of 342 potential prognostic biomarkers in non-small cell lung cancer described between January 2008 and June 2013, evaluating the association between immunohistochemical protein expression and survival endpoint. Numerous studies proposed prognostic biomarkers, but many were only evaluated in a single patient cohort, and a large number of biomarkers revealed inconclusive findings when analyzed in more than one study...
April 2015: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/25526860/crmp1-interacted-with-spy1-during-the-collapse-of-growth-cones-induced-by-sema3a-and-acted-on-regeneration-after-sciatic-nerve-crush
#13
Li Yao, Yong-hua Liu, Xiaohong Li, Yu-hong Ji, Xiao-jing Yang, Xian-ting Hang, Zong-mei Ding, Fang Liu, You-hua Wang, Ai-guo Shen
CRMP1, a member of the collapsin response mediator protein family (CRMPs), was reported to regulate axon outgrowth in Sema3A signaling pathways via interactions with its co-receptor protein neuropilin-1 and plexin-As through the Fyn-cyclin-dependent kinase 5 (CDK5) cascade and the sequential phosphorylation of CRMP1 by lycogen synthase kinase-3β (GSK-3β). Using yeast two-hybrid, we identified a new molecule, Speedy A1 (Spy1), a member of the Speedy/RINGO family, with an interaction with CRMP1. Besides, for the first time, we observed the association of CRMP1 with actin...
March 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/25358863/amino-and-carboxyl-terminal-domains-of-filamin-a-interact-with-crmp1-to-mediate-sema3a-signalling
#14
Fumio Nakamura, Kosuke Kumeta, Tomonobu Hida, Toshinari Isono, Yuichi Nakayama, Emiko Kuramata-Matsuoka, Naoya Yamashita, Yutaka Uchida, Ken-ichi Ogura, Keiko Gengyo-Ando, Shohei Mitani, Toshio Ogino, Yoshio Goshima
Reorganization of the actin cytoskeleton is an early cellular response to various extracellular signals. Sema3A, a repulsive axon guidance molecule, induces the reorganization of actin cytoskeleton in the growth cones. Collapsin response mediator protein 1 (CRMP1) mediates the intracellular Sema3A signalling through its Ser522 phosphorylation. Here we show that UNC-33, CRMP1 C. elegans homologue, interacts with FLN-1, an actin-binding Filamin-A orthologue. In nematodes, this interaction participates in the projection of DD/VD motor neurons...
2014: Nature Communications
https://www.readbyqxmd.com/read/25333879/aggregation-of-the-protein-triobp-1-and-its-potential-relevance-to-schizophrenia
#15
Nicholas J Bradshaw, Verian Bader, Ingrid Prikulis, Angelika Lueking, Stefan Müllner, Carsten Korth
We have previously proposed that specific proteins may form insoluble aggregates as a response to an illness-specific proteostatic dysbalance in a subset of brains from individuals with mental illness, as is the case for other chronic brain conditions. So far, established risk factors DISC1 and dysbindin were seen to specifically aggregate in a subset of such patients, as was a novel schizophrenia-related protein, CRMP1, identified through a condition-specific epitope discovery approach. In this process, antibodies are raised against the pooled insoluble protein fractions (aggregomes) of post mortem brain samples from schizophrenia patients, followed by epitope identification and confirmation using additional techniques...
2014: PloS One
https://www.readbyqxmd.com/read/24765134/collapsin-response-mediator-proteins-potential-diagnostic-and-prognostic-biomarkers-in-cancers-review
#16
Fei Tan, Carol J Thiele, Zhijie Li
The collapsin response mediator proteins (CRMPs) were originally identified as mediators of semaphorin 3A signaling and neuronal differentiation. The CRMP family consists of five homologous cytosolic proteins, CRMP1-5. Altered expression levels of CRMPs have been observed in several malignant tumors, including lung, breast, colorectal, prostate, pancreatic and neuroendocrine lung cancer. The aim of the current study was to review the recent progress achieved in understanding the association between the different levels of CRMP expression in tumors and their involvement in pathological functions, such as tumor metastasis, disease progression, subtype differentiation and clinical outcome, to address the potential value of CRMPs as biomarkers for the diagnosis and prognosis of cancer patients...
May 2014: Oncology Letters
https://www.readbyqxmd.com/read/24652381/mmp-2-mediates-purkinje-cell-morphogenesis-and-spine-development-in-the-mouse-cerebellum
#17
Mieke Verslegers, Inge Van Hove, Eline Dekeyster, Ilse Gantois, Tjing-Tjing Hu, Rudi D'Hooge, Lutgarde Arckens, Lieve Moons
Matrix metalloproteinase-2 (MMP-2) is a highly studied proteolytic enzyme, involved in many detrimental and beneficial functions throughout the body, and also active in the central nervous system (CNS). MMP-2 is profoundly expressed in the developing cerebellum and was recently reported to modulate granule cell proliferation by affecting cell cycle kinetics in cerebella of postnatal day 3 mouse pups. In this report, a two-dimensional difference gel electrophoresis proteomics study was implemented at this postnatal stage and revealed 16 differentially expressed proteins between MMP-2-deficient (MMP-2(-/-)) and wild-type cerebella...
2015: Brain Structure & Function
https://www.readbyqxmd.com/read/24409129/mice-lacking-collapsin-response-mediator-protein-1-manifest-hyperactivity-impaired-learning-and-memory-and-impaired-prepulse-inhibition
#18
Naoya Yamashita, Aoi Takahashi, Keizo Takao, Toshifumi Yamamoto, Pappachan Kolattukudy, Tsuyoshi Miyakawa, Yoshio Goshima
Collapsin response mediator protein 1 (CRMP1) is one of the CRMP family members that are involved in various aspects of neuronal development such as axonal guidance and neuronal migration. Here we provide evidence that crmp1 (-/-) mice exhibited behavioral abnormalities related to schizophrenia. The crmp1 (-/-) mice exhibited hyperactivity and/or impaired emotional behavioral phenotype. These mice also exhibited impaired context-dependent memory and long-term memory retention. Furthermore, crmp1 (-/-) mice exhibited decreased prepulse inhibition, and this phenotype was rescued by administration of chlorpromazine, a typical antipsychotic drug...
2013: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/23838888/autism-specific-maternal-autoantibodies-recognize-critical-proteins-in-developing-brain
#19
D Braunschweig, P Krakowiak, P Duncanson, R Boyce, R L Hansen, P Ashwood, I Hertz-Picciotto, I N Pessah, J Van de Water
Autism spectrum disorders (ASDs) are neurodevelopmental in origin, affecting an estimated 1 in 88 children in the United States. We previously described ASD-specific maternal autoantibodies that recognize fetal brain antigens. Herein, we demonstrate that lactate dehydrogenase A and B (LDH), cypin, stress-induced phosphoprotein 1 (STIP1), collapsin response mediator proteins 1 and 2 (CRMP1, CRMP2) and Y-box-binding protein to comprise the seven primary antigens of maternal autoantibody-related (MAR) autism. Exclusive reactivity to specific antigen combinations was noted in 23% of mothers of ASD children and only 1% of controls...
2013: Translational Psychiatry
https://www.readbyqxmd.com/read/23752245/rare-autosomal-copy-number-variations-in-early-onset-familial-alzheimer-s-disease
#20
B V Hooli, Z M Kovacs-Vajna, K Mullin, M A Blumenthal, M Mattheisen, C Zhang, C Lange, G Mohapatra, L Bertram, R E Tanzi
Over 200 rare and fully penetrant pathogenic mutations in amyloid precursor protein (APP), presenilin 1 and 2 (PSEN1 and PSEN2) cause a subset of early-onset familial Alzheimer's disease (EO-FAD). Of these, 21 cases of EO-FAD families carrying unique APP locus duplications remain the only pathogenic copy number variations (CNVs) identified to date in Alzheimer's disease (AD). Using high-density DNA microarrays, we performed a comprehensive genome-wide analysis for the presence of rare CNVs in 261 EO-FAD and early/mixed-onset pedigrees...
June 2014: Molecular Psychiatry
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