keyword
MENU ▼
Read by QxMD icon Read
search

Anchor

keyword
https://www.readbyqxmd.com/read/28646683/fabrication-of-low-fire-hazard-flexible-poly-vinyl-chloride-via-reutilization-of-heavy-metal-biosorbents
#1
Ye-Tang Pan, De-Yi Wang
As a naturally abundant biopolymer, chitosan is considered to be a suitable adsorbent for stannate (SnO3(2-)) in tin plating wastewater. However, mass transfer of the adsorbent and its recycling remain challenging problems. Though flexible poly(vinyl chloride) (PVC) is highly flammable due to the addition of plasticizers, the traditional flame retardant, antimony trioxide (Sb2O3), is potentially harmful. In this study, chitosan was anchored onto the surface of PVC resin to adsorb SnO3(2-) from wastewater. Thereafter, tin-doped chitosan-coated PVC resin was readily recycled and processed into a flexible PVC composite (modified fPVC)...
June 15, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28646452/dosage-effects-of-zp2-and-zp3-heterozygous-mutations-cause-human-infertility
#2
Wenqiang Liu, Kunming Li, Dandan Bai, Jiqing Yin, Yuanyuan Tang, Fengli Chi, Linfeng Zhang, Yu Wang, Jiaping Pan, Shanshan Liang, Yi Guo, Jingling Ruan, Xiaochen Kou, Yanhong Zhao, Hong Wang, Jiayu Chen, Xiaoming Teng, Shaorong Gao
The zona pellucida (ZP) is an extracellular matrix universally surrounding mammalian eggs, which is essential for oogenesis, fertilization, and pre-implantation embryo development. Here, we identified two novel heritable mutations of ZP2 and ZP3, both occurring in an infertile female patient with ZP-abnormal eggs. Mouse models with the same mutations were generated by CRISPR/Cas9 gene editing system, and oocytes obtained from female mice with either single heterozygous mutation showed approximately half of the normal ZP thickness compared to wild-type oocytes...
June 24, 2017: Human Genetics
https://www.readbyqxmd.com/read/28646414/dynamic-meso-scale-anchorage-of-gpi-anchored-receptors-in-the-plasma-membrane-prion-protein-vs-thy1
#3
Yuri L Nemoto, Roger J Morris, Hiroko Hijikata, Taka A Tsunoyama, Akihiro C E Shibata, Rinshi S Kasai, Akihiro Kusumi, Takahiro K Fujiwara
The central mechanism for the transmission of the prion protein misfolding is the structural conversion of the normal cellular prion protein to the pathogenic misfolded prion protein, by the interaction with misfolded prion protein. This process might be enhanced due to the homo-dimerization/oligomerization of normal prion protein. However, the behaviors of normal prion protein in the plasma membrane have remained largely unknown. Here, using single fluorescent-molecule imaging, we found that both prion protein and Thy1, a control glycosylphosphatidylinositol-anchored protein, exhibited very similar intermittent transient immobilizations lasting for a few seconds within an area of 24...
June 24, 2017: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28646126/how-a-helix-imposes-palmitoylation-of-a-membrane-protein-what-one-can-learn-from-ncx
#4
Daniel Khananshvili
Palmitoylation is a critical post-translational modification that anchors proteins to, and regulates transport across, the lipid bilayer. Palmitoylation enzymes have been assumed to select their substrates based on a protein's primary sequence, but a consensus sequence has been slow to emerge. A study of the sodium/calcium exchanger now suggests that secondary structure may hold the key to understanding the determinants of this modification.
June 23, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28645217/microtubule-organizing-centers
#5
Jingchao Wu, Anna Akhmanova
The organization of microtubule networks is crucial for controlling chromosome segregation during cell division, positioning, and transport of different organelles and for cell polarity and morphogenesis. The geometry of microtubule arrays strongly depends on the localization and activity of the sites where microtubules are nucleated and where their minus ends are anchored. Such sites are often clustered into structures known as microtubule-organizing centers, which include the centrosomes in animals and spindle pole bodies in fungi...
June 23, 2017: Annual Review of Cell and Developmental Biology
https://www.readbyqxmd.com/read/28644867/host-derived-apolipoproteins-play-comparable-roles-with-viral-secretory-proteins-erns-and-ns1-in-the-infectious-particle-formation-of-flaviviridae
#6
Takasuke Fukuhara, Tomokazu Tamura, Chikako Ono, Mai Shiokawa, Hiroyuki Mori, Kentaro Uemura, Satomi Yamamoto, Takeshi Kurihara, Toru Okamoto, Ryosuke Suzuki, Kentaro Yoshii, Takeshi Kurosu, Manabu Igarashi, Hiroshi Aoki, Yoshihiro Sakoda, Yoshiharu Matsuura
Amphipathic α-helices of exchangeable apolipoproteins have shown to play crucial roles in the formation of infectious hepatitis C virus (HCV) particles through the interaction with viral particles. Among the Flaviviridae members, pestivirus and flavivirus possess a viral structural protein Erns or a non-structural protein 1 (NS1) as secretory glycoproteins, respectively, while Hepacivirus including HCV has no secretory glycoprotein. In case of pestivirus replication, the C-terminal long amphipathic α-helices of Erns are important for anchoring to viral membrane...
June 23, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28644821/zirconium-oxocluster-polymer-hybrid-nanoparticles-prepared-by-photoactivated-miniemulsion-copolymerization
#7
Cesare Benedetti, Paraskevi Flouda, Alice Antonello, Christine Rosenauer, Francisco F Perez-Pla, Katharina Landfester, Silvia Gross, Rafael Munoz-Espi
Photoactivated free radical miniemulsion copolymerization of methyl methacrylate (MMA) and the zirconium oxocluster Zr4O2(methacrylate)12 is used as an effective and fast preparation method of polymer/inorganic hybrid nanoparticles. The oxoclusters, covalently anchored to the polymer network, act as metal-organic cross-linkers, thus improving the thermomechanical properties of the resulting hybrid nanoparticles. Benzoin carbonyl organic compounds were used as photoinitiators. The obtained materials are compared in terms of cross-linking, effectiveness of cluster incorporation, and size distribution with the analogous nanoparticles produced by using conventional thermally-induced free radical miniemulsion copolymerization...
June 23, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28644555/a-self-assembled-trigonal-prismatic-molecular-vessel-for-catalytic-dehydration-reactions-in-water
#8
Partha Sarathi Mukherjee, Paramita Das, Atul Kumar, Prodip Howlader
A water-soluble Pd6 trigonal prism (A) was synthesized by two-component coordination-driven self-assembly of a Pd(II) 90° acceptor with a tetraimidazole donor. As the walls of the prism are constructed by three conjugated aromatic building blocks, the confined pocket of the prism is hydrophobic. In addition to the hydrophobic cavity, large product egress windows make A an ideal molecular vessel to catalyze otherwise challenging pseudo multicomponent dehydration reactions in its confined nanospace in aqueous medium...
June 23, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28644485/probing-the-early-stages-of-photoreception-in-photoactive-yellow-protein-with-ultrafast-time-domain-raman-spectroscopy
#9
Hikaru Kuramochi, Satoshi Takeuchi, Kento Yonezawa, Hironari Kamikubo, Mikio Kataoka, Tahei Tahara
Unveiling the nuclear motions of photoreceptor proteins in action is a crucial goal in protein science in order to understand their elaborate mechanisms and how they achieve optimal selectivity and efficiency. Previous studies have provided detailed information on the structures of intermediates that appear during the later stages (>ns) of such photoreception cycles, yet the initial events immediately after photoabsorption remain unclear because of experimental challenges in monitoring nuclear rearrangements on ultrafast timescales, including protein-specific low-frequency motions...
July 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28644059/carbonic-anhydrase-i-ii-iv-and-ix-inhibition-with-a-series-of-7-amino-3-4-dihydroquinolin-2-1h-one-derivatives
#10
Murat Bozdag, Silvia Bua, Sameh M Osman, Zeid AlOthman, Claudiu T Supuran
A series of new derivatives was prepared by derivatisation of the 7-amino moiety present in 7-amino-3,4-dihydroquinolin-2(1H)-one, a compound investigated earlier as CAI. The derivatisation was achieved by: i) reaction with arylsulfonyl isocyanates/aryl isocyanates; (ii) reaction with fluorescein isothiocyanate; (iii) condensation with substituted benzoic acids in the presence of carbodiimides; (iv) reaction with 2,4,6-trimethyl-pyrylium tetrafluoroborate; (v) reaction with methylsulfonyl chloride and (vi) reaction with maleic anhydride...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28644005/from-electrochemistry-to-electroluminescence-development-and-application-in-ratiometric-aptasensor-for-aflatoxin-b1
#11
Long Wu, Fan Ding, Wenmin Yin, Jing Ma, Biru Wang, Axiu Nie, Heyou Han
Aflatoxin B1 (AFB1), one of the most toxic chemical carcinogens, has been widely studied. It remains challenging to develop simple, accurate and sensitive analytical methods for the detection of AFB1 in food matrices. In this work, based on dual-signaling strategy, a ratiometric aptasensor was designed and verified for the accurate and sensitive detection of AFB1. The electrochemical method was first used as a model to verify the specific interaction between AFB1 and the aptamer, in which ferrocene (Fc) and methylene blue (MB) anchored DNA sequences were acted as dual signals...
June 23, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28643105/differential-role-of-gabaa-receptors-and-neuroligin-2-for-perisomatic-gabaergic-synapse-formation-in-the-hippocampus
#12
Patrizia Panzanelli, Simon Früh, Jean-Marc Fritschy
Perisomatic GABAergic synapses onto hippocampal pyramidal cells arise from two populations of basket cells with different neurochemical and functional properties. The presence of the dystrophin-glycoprotein complex in their postsynaptic density (PSD) distinguishes perisomatic synapses from GABAergic synapses on dendrites and the axon-initial segment. Targeted deletion of neuroligin 2 (NL2), a transmembrane protein interacting with presynaptic neurexin, has been reported to disrupt postsynaptic clustering of GABAA receptors (GABAAR) and their anchoring protein, gephyrin, at perisomatic synapses...
June 22, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28642584/molecular-switching-system-using-glycosylphosphatidylinositol-to-select-cells-highly-expressing-recombinant-proteins
#13
Emmanuel Matabaro, Zeng'an He, Yi-Shi Liu, Hui-Jie Zhang, Xiao-Dong Gao, Morihisa Fujita
Although many pharmaceutical proteins are produced in mammalian cells, there remains a challenge to select cell lines that express recombinant proteins with high productivity. Since most biopharmaceutical proteins are secreted by cells into the medium, it is difficult to select cell lines that produce large amounts of the target protein. To address this issue, a new protein expression system using the glycosylphosphatidylinositol (GPI)-anchor was developed. PGAP2 is involved in processing GPI-anchored proteins (GPI-APs) during transport...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28642438/local-protein-kinase-a-action-proceeds-through-intact-holoenzymes
#14
F Donelson Smith, Jessica L Esseltine, Patrick J Nygren, David Veesler, Dominic P Byrne, Matthias Vonderach, Ilya Strashnov, Claire E Eyers, Patrick A Eyers, Lorene K Langeberg, John D Scott
Hormones can transmit signals through adenosine 3',5'-monophosphate (cAMP) to precise intracellular locations. The fidelity of these responses relies on the activation of localized protein kinase A (PKA) holoenzymes. Association of PKA regulatory type II (RII) subunits with A-kinase-anchoring proteins (AKAPs) confers location, and catalytic (C) subunits phosphorylate substrates. Single-particle electron microscopy demonstrated that AKAP79 constrains RII-C subassemblies within 150 to 250 angstroms of its targets...
June 23, 2017: Science
https://www.readbyqxmd.com/read/28641482/insights-into-eukaryotic-evolution-from-transmembrane-domain-lengths
#15
Aditya Mittal, Snigdha Singh
Biological membranes, comprised of proteins anchored by their trans-membrane domains (TMDs) creating a semi-permeable phase with lipid constituents, serve as "checkposts" for not only intracellular trafficking in eukaryotic cells but also for material transactions of all living cells with external environments. Hydropathy (or hydrophobicity) plots of "bitopic" proteins (i.e. having single alpha-helical TMDs) are routinely utilized in biochemistry texts for predicting their TMDs. The number of amino acids (i...
June 22, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28641112/molecular-mechanism-of-mdga1-regulation-of-neuroligin-2-neurexin-trans-synaptic-bridges
#16
Shanti Pal Gangwar, Xiaoying Zhong, Suchithra Seshadrinathan, Hui Chen, Mischa Machius, Gabby Rudenko
Neuroligins and neurexins promote synapse development and validation by forming trans-synaptic bridges spanning the synaptic cleft. Select pairs promote excitatory and inhibitory synapses, with neuroligin 2 (NLGN2) limited to inhibitory synapses and neuroligin 1 (NLGN1) dominating at excitatory synapses. The cell-surface molecules, MAM domain-containing glycosylphosphatidylinositol anchor 1 (MDGA1) and 2 (MDGA2), regulate trans-synaptic adhesion between neurexins and neuroligins, impacting NLGN2 and NLGN1, respectively...
June 21, 2017: Neuron
https://www.readbyqxmd.com/read/28641111/structural-insights-into-modulation-of-neurexin-neuroligin-trans-synaptic-adhesion-by-mdga1-neuroligin-2-complex
#17
Jung A Kim, Doyoun Kim, Seoung Youn Won, Kyung Ah Han, Dongseok Park, Eunju Cho, Nayoung Yun, Hyun Joo An, Ji Won Um, Eunjoon Kim, Jie-Oh Lee, Jaewon Ko, Ho Min Kim
Membrane-associated mucin domain-containing glycosylphosphatidylinositol anchor proteins (MDGAs) bind directly to neuroligin-1 (NL1) and neuroligin-2 (NL2), thereby respectively regulating excitatory and inhibitory synapse development. However, the mechanisms by which MDGAs modulate NL activity to specify development of the two synapse types remain unclear. Here, we determined the crystal structures of human NL2/MDGA1 Ig1-3 complex, revealing their stable 2:2 arrangement with three interaction interfaces. Cell-based assays using structure-guided, site-directed MDGA1 mutants showed that all three contact patches were required for the MDGA's negative regulation of NL2-mediated synaptogenic activity...
June 21, 2017: Neuron
https://www.readbyqxmd.com/read/28640665/mrna-localization-in-metazoans-a-structural-perspective
#18
Daniela Lazzaretti, Fulvia Bono
Asymmetric localization of mRNAs is a widespread gene regulatory mechanism that is crucial for many cellular processes. The localization of a transcript involves multiple steps and requires several protein factors to mediate transport, anchoring and translational repression of the mRNA. Specific recognition of the localizing transcript is a key step that depends on linear or structured localization signals, which are bound by RNA-binding proteins. Genetic studies have identified many components involved in mRNA localization...
June 22, 2017: RNA Biology
https://www.readbyqxmd.com/read/28640315/formation-and-field-driven-dynamics-of-nematic-spheroids
#19
Fred Fu, Nasser Mohieddin Abukhdeir
Unlike the canonical application of liquid crystals (LCs), LC displays, emerging technologies based on LC materials are increasingly leveraging the presence of nanoscale defects. The inherent nanoscale characteristics of LC defects present both significant opportunities as well as barriers for the application of this fascinating class of materials. Simulation-based approaches to the study of the effects of confinement and interface anchoring conditions on LC domains has resulted in significant progress over the past decade, where simulations are now able to access experimentally-relevant length scales while simultaneously capturing nanoscale defect structures...
June 22, 2017: Soft Matter
https://www.readbyqxmd.com/read/28640299/anchoring-groups-for-photocatalytic-water-oxidation-on-metal-oxide-surfaces
#20
Kelly L Materna, Robert H Crabtree, Gary W Brudvig
Surface anchoring groups are needed to attach molecular units to photoanodes for photocatalytic water oxidation. The anchoring group must be hydrolytically stable and oxidation resistant under a variety of pH conditions. They must sometimes be electrically conducting for efficient light-induced electron injection from a photosensitizer to a metal oxide, but other times not conducting for accumulation of oxidizing equivalents on a water-oxidation catalyst. Commonly used anchors such as carboxylic acids and phosphonic acids have limited stability in aqueous environments, leading to surface hydrolysis and loss of catalytic function...
June 22, 2017: Chemical Society Reviews
keyword
keyword
53417
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"