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https://www.readbyqxmd.com/read/28918102/the-minimal-clinically-important-difference-for-the-rasch-neuropsychiatric-inventory-irritability-and-aggression-scale-for-traumatic-brain-injury
#1
James F Malec, Flora M Hammond
OBJECTIVE: To determine the Minimal Clinically Important Difference (MCID) for a Rasch measure derived from the Irritability/Lability and Agitation/Aggression subscales of the Neuropsychiatric Inventory (NPI-TBI-IA). DESIGN: Distribution-based statistical methods were applied to retrospective data to determine candidates for the MCID. These candidates were evaluated by anchoring the NPI-TBI-IA to Global Impression of Change (GIC) ratings by participants, significant others, and a supervising physician...
September 13, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28917904/metal-organic-framework-preparation-using-magnetic-graphene-oxide-%C3%AE-cyclodextrin-for-neonicotinoid-pesticide-adsorption-and-removal
#2
Guangyang Liu, Lingyun Li, Donghui Xu, Xiaodong Huang, Xiaomin Xu, Shuning Zheng, Yanguo Zhang, Huan Lin
A novel magnetic copper-based metal-organic framework (M-MOF) was prepared using a Fe4O3-graphene oxide (GO)-β-cyclodextrin (β-CD) nanocomposite as the magnetic core and support, and used for adsorption and removal of neonicotinoid insecticide pollutants from aqueous solution. M-MOF characterization suggested that (1)Fe4O3-GO-β-CD consisted of a thin single layer with anchored Fe3O4. The M-MOF was coated on the Fe4O3-GO-β-CD surface. The M-MOF had a large Brunauer-Emmett-Teller surface area (250.33m(2)g(-1)) and high super-paramagnetism with saturation magnetization of 10...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917396/modified-bean-shaped-ring-segments-for-suture-fixation-of-the-bag-in-the-lens-intraocular-implant
#3
Sorcha Ní Dhubhghaill, Anca Cristina Dogaroiu, Nadia Zakaria, Marie-José Tassignon
We describe a surgical technique for secondary stabilization of a bag-in-the-lens intraocular lens (BIL IOL) using 2 modified bean-shaped ring segments in cases of zonular dehiscence associated with pseudophakodonesis. The first modified bean segment is anchored in the sulcus with a suture to the sclera in the area of maximum zonular dehiscence, and the second segment is implanted in the opposite sulcus area. Both segments are placed in the BIL IOL interhaptic groove. The segments stabilize and center the BIL IOL by creating an artificial zonule that provides the necessary extra support for the IOL...
August 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28916831/the-melanocortin-signaling-camp-axis-accelerates-repair-and-reduces-mutagenesis-of-platinum-induced-dna-damage
#4
Stuart G Jarrett, Katharine M Carter, Brent J Shelton, John A D'Orazio
Using primary melanocytes and HEK293 cells, we found that cAMP signaling accelerates repair of bi- and mono-functional platinum-induced DNA damage. Elevating cAMP signaling either by the agonistic MC1R ligand melanocyte stimulating hormone (MSH) or by pharmacologic cAMP induction by forskolin enhanced clearance of intrastrand cisplatin-adducts in melanocytes or MC1R-transfected HEK293 cells. MC1R antagonists human beta-defensin 3 and agouti signaling protein blocked MSH- but not forskolin-mediated enhancement of platinum-induced DNA damage...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28916764/rapid-and-reversible-epigenome-editing-by-endogenous-chromatin-regulators
#5
Simon M G Braun, Jacob G Kirkland, Emma J Chory, Dylan Husmann, Joseph P Calarco, Gerald R Crabtree
Understanding the causal link between epigenetic marks and gene regulation remains a central question in chromatin biology. To edit the epigenome we developed the FIRE-Cas9 system for rapid and reversible recruitment of endogenous chromatin regulators to specific genomic loci. We enhanced the dCas9-MS2 anchor for genome targeting with Fkbp/Frb dimerizing fusion proteins to allow chemical-induced proximity of a desired chromatin regulator. We find that mSWI/SNF (BAF) complex recruitment is sufficient to oppose Polycomb within minutes, leading to activation of bivalent gene transcription in mouse embryonic stem cells...
September 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28916347/boat-anchoring-pressure-on-coastal-seabed-quantification-and-bias-estimation-using-ais-data
#6
Julie Deter, Xavier Lozupone, Adrien Inacio, Pierre Boissery, Florian Holon
Global shipping is economically important, but has many adverse environmental effects. Anchoring contributes greatly to this adverse impact, as it is responsible for mechanical disturbance of highly sensitive marine habitats. Recovery of these ecosystems is limited by slow regrowth. Anchoring pressure on coastal seabed habitats was estimated using AIS (Automatic Identification System) data along 1800km of Mediterranean coastline between 2010 and 2015. A comparison with field observations showed that these results were most consistent for large boats (>50m)...
September 12, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28916265/glycans-function-as-anchors-for-antibodies-and-help-drive-hiv-broadly-neutralizing-antibody-development
#7
Raiees Andrabi, Ching-Yao Su, Chi-Hui Liang, Sachin S Shivatare, Bryan Briney, James E Voss, Salar Khan Nawazi, Chung-Yi Wu, Chi-Huey Wong, Dennis R Burton
Apex broadly neutralizing HIV antibodies (bnAbs) recognize glycans and protein surface close to the 3-fold axis of the envelope (Env) trimer and are among the most potent and broad Abs described. The evolution of apex bnAbs from one donor (CAP256) has been studied in detail and many Abs at different stages of maturation have been described. Using diverse engineering tools, we investigated the involvement of glycan recognition in the development of the CAP256.VRC26 Ab lineage. We found that sialic acid-bearing glycans were recognized by germline-encoded and somatically mutated residues on the Ab heavy chain...
September 8, 2017: Immunity
https://www.readbyqxmd.com/read/28915925/biomechanical-analysis-of-the-posterior-bony-column-of-the-lumbar-spine
#8
Jiukun Li, Shuai Huang, Yubo Tang, Xi Wang, Tao Pan
BACKGROUND: Each part of the rear bone structure can become an anchor point for an attachment device. The objective of this study was to evaluate the stiffness and strength of different parts of the rear lumbar bone structure by axial compression damage experiments. METHODS: Five adult male lumbar bone structures from L2 to L5 were exposed. The superior and inferior articular processes, upper and lower edges of the lamina, and upper and lower edges of the spinous process were observed and isolated and then divided into six groups (n = 10)...
September 15, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28915793/the-cacao-criollo-genome-v2-0-an-improved-version-of-the-genome-for-genetic-and-functional-genomic-studies
#9
X Argout, G Martin, G Droc, O Fouet, K Labadie, E Rivals, J M Aury, C Lanaud
BACKGROUND: Theobroma cacao L., native to the Amazonian basin of South America, is an economically important fruit tree crop for tropical countries as a source of chocolate. The first draft genome of the species, from a Criollo cultivar, was published in 2011. Although a useful resource, some improvements are possible, including identifying misassemblies, reducing the number of scaffolds and gaps, and anchoring un-anchored sequences to the 10 chromosomes. METHODS: We used a NGS-based approach to significantly improve the assembly of the Belizian Criollo B97-61/B2 genome...
September 15, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28915673/prognositic-value-of-cd73-adenosinergic-pathway-in-solid-tumor-a-meta-analysis-and-systematic-review
#10
Rong Wang, Yingying Zhang, Xia Lin, Yalin Gao, Ying Zhu
CD73 is a glycosylphosphatidylinositol (GPI) anchored cell surface protein that is encoded by NT5E gene, plays multiple roles in tumor processes. Previous studies have presented a potential value of CD73 served as a detectable biomarker for prognosis of several solid tumors, but the results were more controversially. A comprehensive meta-analysis was conducted to precisely evaluate the prognostic role of CD73 in solid tumors. The included studies were searched in PubMed, Web of Science and EBSCO from Jan 1990 to Jan 2016...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915498/tantalum-coated-pedicle-screws-enhance-implant-integration
#11
Liang-Yu Shi, An Wang, Fa-Zhi Zang, Jian-Xi Wang, Xian-Wei Pan, Hua-Jiang Chen
Because titanium alloy (Ti) has the natural advantage of a low elastic modulus, it has become the most commonly used material for the manufacturing of pedicle screws. However, its poor shear strength and osteogenic ability are undesirable properties. The superior osteoinductivity demonstrated by tantalum (Ta) in oral and maxillofacial surgery and joint surgery leads us to assume that the tantalum-coated pedicle screws may have better osteogenic properties and bone anchoring strength. To verify this hypothesis, MC3T3-E1 cells and human mesenchymal stem cells (hBMSCs) were seeded on the surface of Ta and Ti disks to compare the effects of two different metals on cell adhesion, proliferation, and differentiation...
September 7, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28915252/expression-and-regulation-of-the-neutral-amino-acid-transporter-b0at1-in-rat-small-intestine
#12
Julia Jando, Simone M R Camargo, Brigitte Herzog, François Verrey
Absorption of neutral amino acids across the luminal membrane of intestinal enterocytes is mediated by the broad neutral amino acid transporter B0AT1 (SLC6A19). Its intestinal expression depends on co-expression of the membrane-anchored peptidase angiotensin converting enzyme 2 (ACE2) and is additionally enhanced by aminopeptidase N (CD13). We investigated in this study the expression of B0AT1 and its auxiliary peptidases as well as its transport function along the rat small intestine. Additionally, we tested its possible short- and long-term regulation by dietary proteins and amino acids...
2017: PloS One
https://www.readbyqxmd.com/read/28914990/simulating-the-multi-disciplinary-care-team-approach-enhancing-student-understanding-of-anatomy-through-an-ultrasound-anchored-interprofessional-session
#13
Marianne T Luetmer, Beth A Cloud, James W Youdas, Wojciech Pawlina, Nirusha Lachman
Quality of healthcare delivery is dependent on collaboration between professional disciplines. Integrating opportunities for interprofessional learning in health science education programs prepares future clinicians to function as effective members of a multi-disciplinary care team. This study aimed to create a modified team-based learning (TBL) environment utilizing ultrasound technology during an interprofessional learning activity to enhance musculoskeletal anatomy knowledge of first year medical (MD) and physical therapy (PT) students...
September 15, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/28914738/age-related-resting-state-functional-connectivity-in-the-olfactory-and-trigeminal-networks
#14
Prasanna Karunanayaka, Michael J Tobia, Qing X Yang
Brain networks for intranasal chemosensation have been shown to be intrinsically organized in humans . However, little is known about how changes in the intrinsic functional connectivity (FC) in chemosensory networks are related to aging. We, therefore, investigated the impact of age on resting-state FC in the olfactory and trigeminal networks (ON and TN) by combining two freely available resting-state fMRI data sets (obtained from the NITRC.org; Atlanta and New York) with data collected in our lab to generate a large sample size (N=103; 51 women) spanning the age range of 20-61 years...
October 18, 2017: Neuroreport
https://www.readbyqxmd.com/read/28914463/burrowing-with-a-kinetic-snout-in-a-snake-elapidae-aspidelaps-scutatus
#15
Alexandra Deufel
Of the few elongate, fossorial vertebrates that have been examined for their burrowing mechanics, all were found to use an akinetic, reinforced skull to push into the soil, powered mostly by trunk muscles. Reinforced skulls were considered essential for head-first burrowing. In contrast, I found that the skull of the fossorial shield-nosed cobra (Aspidelaps scutatus) is not reinforced and retains the kinetic potential typical of many non-fossorial snakes. Aspidelaps scutatus burrows using a greatly enlarged rostral scale that is attached to a kinetic snout that is independently mobile with respect to the rest of the skull...
September 15, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28913963/reporting-to-improve-reproducibility-and-facilitate-validity-assessment-for-healthcare-database-studies-v1-0
#16
Shirley V Wang, Sebastian Schneeweiss, Marc L Berger, Jeffrey Brown, Frank de Vries, Ian Douglas, Joshua J Gagne, Rosa Gini, Olaf Klungel, C Daniel Mullins, Michael D Nguyen, Jeremy A Rassen, Liam Smeeth, Miriam Sturkenboom
PURPOSE: Defining a study population and creating an analytic dataset from longitudinal healthcare databases involves many decisions. Our objective was to catalogue scientific decisions underpinning study execution that should be reported to facilitate replication and enable assessment of validity of studies conducted in large healthcare databases. METHODS: We reviewed key investigator decisions required to operate a sample of macros and software tools designed to create and analyze analytic cohorts from longitudinal streams of healthcare data...
September 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28913877/minimal-important-difference-of-target-lobar-volume-reduction-after-endobronchial-valve-treatment-for-emphysema
#17
Jorrit B A Welling, Jorine E Hartman, Eva M van Rikxoort, Nick H T Ten Hacken, Huib A M Kerstjens, Karin Klooster, Dirk-Jan Slebos
BACKGROUND AND OBJECTIVE: Target lobar volume reduction (TLVR) is an important efficacy outcome measure for bronchoscopic lung volume reduction (BLVR) treatment using one-way endobronchial valves (EBV) in patients with severe emphysema. The commonly used cut-off value for TLVR that expresses a perceivable clinical benefit is -350 mL. However, a scientifically determined minimal important difference (MID) for TLVR never has been published. The objective of the present study was to determine the MID for TLVR on HRCT in patients who were treated with EBV...
September 15, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28913137/intra-cesarean-insertion-and-fixation-of-frameless-intrauterine-devices
#18
REVIEW
Ateş Karateke, Abdulkadir Turgut, Özkan Özdamar, Dirk Wildemeersch
Various contraceptive methods are available to postpartum women including hormonal and nonhormonal barriers, as well as injectable forms. Of all the available birth control methods, intrauterine devices (IUD) are felt by many to be the near-ideal form of contraception, and are recommended by advocacy groups, physicians, and gynecological organizations worldwide. Immediate postpartum IUD insertion deserves greater attention because it can provide immediate contraception, prevents repeat unintended pregnancies, and may serve to reduce the incidence or need for secondary cesarean delivery; however, insertion of conventional T-shape IUDs immediately post placenta delivery is limited by their high expulsion and displacement rates...
March 2017: Turk J Obstet Gynecol
https://www.readbyqxmd.com/read/28912832/unique-organization-and-unprecedented-diversity-of-the-bacteroides-pseudobacteroides-cellulosolvens-cellulosome-system
#19
Olga Zhivin, Bareket Dassa, Sarah Moraïs, Sagar M Utturkar, Steven D Brown, Bernard Henrissat, Raphael Lamed, Edward A Bayer
BACKGROUND: (Pseudo) Bacteroides cellulosolvens is an anaerobic, mesophilic, cellulolytic, cellulosome-producing clostridial bacterium capable of utilizing cellulose and cellobiose as carbon sources. Recently, we sequenced the B. cellulosolvens genome, and subsequent comprehensive bioinformatic analysis, herein reported, revealed an unprecedented number of cellulosome-related components, including 78 cohesin modules scattered among 31 scaffoldins and more than 200 dockerin-bearing ORFs...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28912638/chronic-pain-assessments-in-children-and-adolescents-a-systematic-literature-review-of-the-selection-administration-interpretation-and-reporting-of-unidimensional-pain-intensity-scales
#20
REVIEW
Rebecca Rachael Lee, Amir Rashid, Daniela Ghio, Wendy Thomson, Lis Cordingley
BACKGROUND: Advances in pain assessment approaches now indicate which measures should be used to capture chronic pain experiences in children and adolescents. However, there is little guidance on how these tools should best be administered and reported, such as which time frames to use or how pain scores are categorised as mild, moderate, or severe. OBJECTIVE: To synthesise current evidence on unidimensional, single-item pain intensity scale selection, administration, interpretation, and reporting...
2017: Pain Research & Management: the Journal of the Canadian Pain Society
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