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https://www.readbyqxmd.com/read/28749467/yet-another-hump-for-caml-support-of-cell-survival-independent-of-tail-anchored-protein-insertion
#1
Jennifer C Shing, Richard J Bram
No abstract text is available yet for this article.
July 27, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28749326/pneumococcal-neuraminidase-activates-tgf-%C3%AE-signalling
#2
Nina Gratz, Lip Nam Loh, Beth Mann, Geli Gao, Robert Carter, Jason Rosch, Elaine I Tuomanen
Neuraminidase A (NanA) is an important virulence factor that is anchored to the pneumococcal cell wall and cleaves sialic acid on host substrates. We noted that a secreted allele of NanA was over-represented in invasive pneumococcal isolates and promoted the development of meningitis when swapped into the genome of non-meningitis isolates replacing cell wall-anchored NanA. Both forms of recombinant NanA directly activated transforming growth factor (TGF)-β, increased SMAD signalling and promoted loss of endothelial tight junction ZO-1...
July 28, 2017: Microbiology
https://www.readbyqxmd.com/read/28748956/thermally-stable-single-atom-pt-m-al2o3-for-selective-hydrogenation-and-co-oxidation
#3
Zailei Zhang, Yihan Zhu, Hiroyuki Asakura, Bin Zhang, Jiaguang Zhang, Maoxiang Zhou, Yu Han, Tsunehiro Tanaka, Aiqin Wang, Tao Zhang, Ning Yan
Single-atom metal catalysts offer a promising way to utilize precious noble metal elements more effectively, provided that they are catalytically active and sufficiently stable. Herein, we report a synthetic strategy for Pt single-atom catalysts with outstanding stability in several reactions under demanding conditions. The Pt atoms are firmly anchored in the internal surface of mesoporous Al2O3, likely stabilized by coordinatively unsaturated pentahedral Al(3+) centres. The catalyst keeps its structural integrity and excellent performance for the selective hydrogenation of 1,3-butadiene after exposure to a reductive atmosphere at 200 °C for 24 h...
July 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/28748758/protozoan-parasites-glycosylphosphatidylinositol-anchors-structures-functions-and-trends-for-drug-discovery
#4
Ana Luísa Malaco Morotti, Maristela Braga Martins-Teixeira, Ivone Carvalho
Glycosylphosphatidylinositol (GPI) anchors are complex molecules that support certain proteins in the outer leaflet of the cell membrane. The GPI anchor scaffold is comprised of a glycan core which contains a phosphoethanolamine linker and a phospholipid chain. GPI-anchored proteins are structurally and functionally diverse and play essential roles in several biological processes, in particular cell-cell interaction. Although all eukaryotes possess GPI anchors in their cell membrane, protozoan parasites use this anchorage much more frequently than higher eukaryotes...
July 27, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28748463/detection-of-in-vivo-mutation-in-the-pig-a-gene-of-mouse-bone-marrow-erythroids
#5
Takafumi Kimoto, Daishiro Miura
Detection of in vivo mutation is important for evaluating the health risks associated with chemicals. The Pig-a in vivo gene mutation assay has been developed over the last decade for this purpose. Most approaches for the assay, however, measure cells with a Pig-a mutant phenotype in erythrocytes from the peripheral blood, with the mutations causing the phenotype being difficult to determine directly. This chapter describes a procedure for detecting mutations in the Pig-a gene of phenotypically mutant mouse bone marrow erythroids, the precursors of peripheral blood erythrocytes...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28748462/in-vivo-rat-t-lymphocyte-pig-a-assay-detection-and-expansion-of-cells-deficient-in-the-gpi-anchored-cd48-surface-marker-for-analysis-of-mutation-in-the-endogenous-pig-a-gene
#6
Vasily N Dobrovolsky, Javier Revollo, Dayton M Petibone, Robert H Heflich
The Pig-a assay is being developed as an in vivo gene mutation assay for regulatory safety assessments. The assay is based on detecting mutation in the endogenous Pig-a gene of treated rats by using flow cytometry to measure changes in cell surface markers of peripheral blood cells. Here we present a methodology for demonstrating that phenotypically mutant rat T-cells identified by flow cytometry contain mutations in the Pig-a gene, an important step for validating the assay. In our approach, the mutant phenotype T-cells are sorted into individual wells of 96-well plates and expanded into clones...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28748291/predictors-of-outcomes-after-arthroscopic-transosseous-equivalent-rotator-cuff-repair-in-155-cases-a-propensity-score-weighted-analysis-of-knotted-and-knotless-self-reinforcing-repair-techniques-at-a-minimum-of-2%C3%A2-years
#7
Peter J Millett, Chris Espinoza, Marilee P Horan, Charles P Ho, Ryan J Warth, Grant J Dornan, J Christoph Katthagen
PURPOSE: To evaluate the outcomes of two commonly used transosseous-equivalent (TOE) arthroscopic rotator cuff repair (RCR) techniques for full-thickness supraspinatus tendon tears (FTST) using a robust multi-predictor model. METHODS: 155 shoulders in 151 patients (109 men, 42 women; mean age 59 ± 10 years) who underwent arthroscopic RCR of FTST, using either a knotted suture bridging (KSB) or a knotless tape bridging (KTB) TOE technique were included. ASES and SF-12 PCS scores assessed at a minimum of 2 years postoperatively were modeled using propensity score weighting in a multiple linear regression model...
July 26, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28747604/methotrexate-associated-lymphoproliferative-disorder
#8
Yuko Kaneko
  Methotrexate-associated lymphproliferative disorder (MTX-LPD) is a rare but critical complication developing in patients treated with methotrexate. Now that methotrexate is an anchor drug in the management of rheumatoid arthritis and become commonly used, MTX-LPD cases have increased. Many things has been unclear such as incidence, demographic characters, and risk factors. However, as the researches increased, several interesting topics has been demonstrated like associations with Epsteiin-Barr virus and with cell-mediated immunity...
2017: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
https://www.readbyqxmd.com/read/28747517/a-soft-robotic-exosuit-improves-walking-in-patients-after-stroke
#9
Louis N Awad, Jaehyun Bae, Kathleen O'Donnell, Stefano M M De Rossi, Kathryn Hendron, Lizeth H Sloot, Pawel Kudzia, Stephen Allen, Kenneth G Holt, Terry D Ellis, Conor J Walsh
Stroke-induced hemiparetic gait is characteristically slow and metabolically expensive. Passive assistive devices such as ankle-foot orthoses are often prescribed to increase function and independence after stroke; however, walking remains highly impaired despite-and perhaps because of-their use. We sought to determine whether a soft wearable robot (exosuit) designed to supplement the paretic limb's residual ability to generate both forward propulsion and ground clearance could facilitate more normal walking after stroke...
July 26, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28747267/a-new-femoral-fixation-device-for-anterior-cruciate-ligament-reconstruction-using-the-outside-in-technique-and-hamstring-tendon-graft-a-comparison-between-two-devices-in-cadaveric-human-knee-models
#10
Suri Chong, Dai-Soon Kwak, Dhanasekaraprabu Balasubramanian, Young Dong Song, Young Gon Na, Tae Kyun Kim
BACKGROUND: A new device (T-anchor) was developed for ACL reconstruction and is implanted via the outside-in technique using hamstring grafts. The purpose of this study was to compare the T-anchor with the EndoButton Direct. METHODS: This study was conducted on 30 cadaveric knees (15 matched pairs). There were two groups of 15 each in the T-anchor and EndoButton Direct groups. After the harvest of grafts, fixation site profile and graft length were measured by loading the grafts onto both devices...
July 23, 2017: Knee
https://www.readbyqxmd.com/read/28746905/a-pm7-dynamic-residue-ligand-interactions-energy-landscape-of-the-bace1-inhibitory-pathway-by-hydroxyethylamine-compounds-part-i-the-flap-closure-process
#11
Carlos Gueto-Tettay, Alejandro Martinez-Consuegra, Joshua Zuchniarz, Luis Roberto Gueto-Tettay, Juan Carlos Drosos-Ramírez
BACE1 is an enzyme of scientific interest because it participates in the progression of Alzheimer's disease. Hydroxyethylamines (HEAs) are a family of compounds which exhibit inhibitory activity toward BACE1 at a nanomolar level, favorable pharmacokinetic properties and oral bioavailability. The first step in the inhibition of BACE1 by HEAs consists of their entrance into the protease active site and the resultant conformational change in the protein, from Apo to closed form. These two conformations differ in the position of an antiparallel loop (called the flap) which covers the entrance to the catalytic site...
July 14, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28746744/enzyme-responsive-lipocest-agents-assessment-of-mmp-2-activity-by-measuring-the-intra-liposomal-water-1h-nmr-resonance-shift
#12
Giuseppe Ferrauto, Enza Di Gregorio, Marta Ruzza, Valeria Catanzaro, Sergio Padovan, Silvio Aime
Mobile proton containing solutes can be detected by MRI via Chemical Exchange Saturation Transfer(CEST)method. The CEST sensitivity is dramatically enhanced by using, as exchanging protons, the water molecules confined inside liposomes, properly shifted by a paramagnetic Shift Reagent. The chemical shift of the intraliposomal water resonance(δIL) is affected by the overall shape of the supramolecular system. Herein, it is shown that δIL of a spherical LipoCEST acts as a sensitive reporter of the distribution of Streptavidin proteins anchored at the Liposomes'surface by biotinylated phospholipids...
July 26, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28746500/domestic-violence-against-children-and-adolescents-social-support-network-perspectives
#13
Diene Monique Carlos, Elisabete Matallo Marchesini De Pádua, Maria Isabel Domingues Fernandes, Maria Neto da Cruz Leitão, Maria das Graças Carvalho Ferriani
Objective: To identify and analyze the social support network of families involved in violence against children and adolescents, from the perspective of health professionals and families in a municipality of the state of São Paulo, Brazil. Methods: This was a qualitative strategic social study, anchored in the paradigm of complexity. Data were collected from 41 health professionals and 15 families using institutional or personal network maps, and semi-structured interviews...
July 20, 2017: Revista Gaúcha de Enfermagem
https://www.readbyqxmd.com/read/28746493/miniscrew-assisted-rapid-palatal-expansion-for-managing-arch-perimeter-in-an-adult-patient
#14
Amanda Carneiro da Cunha, Hisun Lee, Lincoln Issamu Nojima, Matilde da Cunha Gonçalves Nojima, Kee-Joon Lee
Introduction: Etiology of dental crowding may be related to arch constriction in diverse dimensions, and an appropriate manipulation of arch perimeter by intervening in basal bone discrepancies cases, may be a key for crowding relief, especially when incisors movement is limited due to underlying pathology, periodontal issues or restrictions related to soft tissue profile. Objectives: This case report illustrates a 24-year old woman, with maxillary transverse deficiency, upper and lower arches crowding, Class II, division 1, subdivision right relationship, previous upper incisors traumatic episode and straight profile...
May 2017: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/28746399/coordination-of-matrix-attachment-and-atp-dependent-chromatin-remodeling-regulate-auxin-biosynthesis-and-arabidopsis-hypocotyl-elongation
#15
Kyounghee Lee, Pil Joon Seo
Hypocotyl elongation is extensively controlled by hormone signaling networks. In particular, auxin metabolism and signaling play key roles in light-dependent hypocotyl growth. The nuclear matrix facilitates organization of DNA within the nucleus, and dynamic interactions between nuclear matrix and DNA are related to gene regulation. Conserved scaffold/matrix attachment regions (S/MARs) are anchored to the nuclear matrix by the AT-HOOK MOTIF CONTAINING NUCLEAR LOCALIZED (AHL) proteins in Arabidopsis. Here, we found that ESCAROLA (ESC)/AHL27 and SUPPRESSOR OF PHYTOCHROME B-4 #3 (SOB3)/AHL29 redundantly regulate auxin biosynthesis in the control of hypocotyl elongation...
2017: PloS One
https://www.readbyqxmd.com/read/28746398/tomosyn-associates-with-secretory-vesicles-in-neurons-through-its-n-and-c-terminal-domains
#16
Cornelia J Geerts, Roberta Mancini, Ning Chen, Frank T W Koopmans, Ka Wan Li, August B Smit, Jan R T van Weering, Matthijs Verhage, Alexander J A Groffen
The secretory pathway in neurons requires efficient targeting of cargos and regulatory proteins to their release sites. Tomosyn contributes to synapse function by regulating synaptic vesicle (SV) and dense-core vesicle (DCV) secretion. While there is large support for the presynaptic accumulation of tomosyn in fixed preparations, alternative subcellular locations have been suggested. Here we studied the dynamic distribution of tomosyn-1 (Stxbp5) and tomosyn-2 (Stxbp5l) in mouse hippocampal neurons and observed a mixed diffuse and punctate localization pattern of both isoforms...
2017: PloS One
https://www.readbyqxmd.com/read/28745494/surface-anchored-thiol-reactive-soft-interfaces-engineering-effective-platforms-for-biomolecular-immobilization-and-sensing
#17
Tugce Nihal Gevrek, Irem Kosif, Amitav Sanyal
Fabrication of anti-biofouling, yet specifically reactive polymeric coatings which undergo facile functionalization with thiol-bearing small molecules and ligands yield effective platforms for biomolecular immobilization and sensing. Poly(ethylene glycol) (PEG) based copolymers containing alkoxysilyl groups to enable surface-anchoring and furan-protected maleimide groups as latent thiol-reactive moieties as side-chains were synthesized. Reactive interfaces were obtained by coating these copolymers onto Si/SiO2 or glass surfaces and activating the maleimide groups to their thiol-reactive forms via thermal treatment...
July 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28745343/a-comparative-study-of-the-influence-of-n-n-dialkyl-vs-n-n-diaryl-based-electron-donor-ancillary-ligands-on-photocurrent-and-photovoltage-in-dye-sensitized-solar-cells-dsscs
#18
Saba Ashraf, Erol Yildirim, Javeed Akhtar, Humaira M Siddiqi, Ahmed El-Shafei
In this study, we report the synthesis of a novel heteroleptic Ru(ii)-sensitizer, (Ru(2,2'-bipyridine-4,4'-dicarboxylic acid)-4,4'-bis(4-piperidin-1-yl)phenyl ethenyl)-(2,2'-bipyridine) (NCS)2, denoted as SD-1; moreover, its photophysical, electrochemical, and photovoltaic performances were compared with those of N719 and K77-7 (N,N'-diaryl Ru-sensitizer, namely Ru(2,2'-bipyridine-4,4'-dicarboxylic-acid)-4,4'-bis(2-(4-N,N'-diphenylaminophenyl)ethenyl)-2,2'-bipyridine (NCS)2). The photovoltaic performance of SD-1 outperformed those of N-719 and K77-7, particularly in the red region, and the overall efficiency of SD-1 was 8...
July 26, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28743923/transformation-induced-changes-in-the-dna-nuclear-matrix-interface-revealed-by-high-throughput-analysis-of-dna-halos
#19
Rosemary H C Wilson, Dawn Coverley
In higher eukaryotic nuclei, DNA is periodically anchored to an extraction-resistant protein structure, via matrix attachment regions. We describe a refined and accessible method to non-subjectively, rapidly and reproducibly measure both size and stability of the intervening chromatin loops, and use it to demonstrate that malignant transformation compromises the DNA-nuclear matrix interface.
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28743912/structural-basis-for-dolichylphosphate-mannose-biosynthesis
#20
Rosaria Gandini, Tom Reichenbach, Tien-Chye Tan, Christina Divne
Protein glycosylation is a critical protein modification. In biogenic membranes of eukaryotes and archaea, these reactions require activated mannose in the form of the lipid conjugate dolichylphosphate mannose (Dol-P-Man). The membrane protein dolichylphosphate mannose synthase (DPMS) catalyzes the reaction whereby mannose is transferred from GDP-mannose to the dolichol carrier Dol-P, to yield Dol-P-Man. Failure to produce or utilize Dol-P-Man compromises organism viability, and in humans, several mutations in the human dpm1 gene lead to congenital disorders of glycosylation (CDG)...
July 25, 2017: Nature Communications
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