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Pediatric oncology

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https://www.readbyqxmd.com/read/29032616/a-survey-on-hematology-oncology-pediatric-aieop-centres-the-challenge-of-posterior-reversible-encephalopathy-syndrome
#1
Daniele Zama, Pietro Gasperini, Massimo Berger, Mariagrazia Petris, Maria D De Pasquale, Simone Cesaro, Maria E Guerzoni, Elena Mastrodicasa, Francesca Savina, Ottavio Ziino, Valentina Kiren, Paola Muggeo, Rosa M Mura, Fraia Melchionda, Giulio A Zanazzo
Posterior reversible encephalopathy syndrome (PRES) is one of the most common neurological complications in hematology-oncology pediatric patients. Despite an increasingly recognized occurrence, no clear consensus exists regarding how best to manage the syndrome, because most cases of PRES have reported in single case reports or small series. Aim of this paper is to identify incidence, clinical features, management and outcome of PRES in a large series of hematology-oncology pediatric patients METHODS: The cases of PRES occurred in twelve centres of the Italian Association of Pediatric Haematology and Oncology were reported RESULTS: 124 cases of PRES in 112 pediatric patients were recorded with an incidence of 2...
October 15, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/29031040/-treatment-refusal-in-pediatric-oncology
#2
A Špótová, K Husáková, A Hrašková, M Mikesková, J Puškáčová, S Hederová, M Jamárik, E Rabenseifertová, Z Jalovecká, A Kolenová, Z Šubová
BACKGROUND: Pediatric oncologists are often faced with situations in which parents or guardians refuse recommended treatment for curable childhood cancer. Deciding how to proceed in such situations is an ethical dilemma. The aim of this article is to consider optimal approaches when parents are strongly against oncological treatment, potentially compromising their childrens rights for health care and to the chance for cure. CASES: In this paper, we report two cases of treatment refusal from our department and the impact of such decisions on the children themselves...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29028221/quality-of-life-and-patient-reported-outcomes-following-proton-radiation-therapy-a-systematic-review
#3
REVIEW
Vivek Verma, Charles B Simone, Mark V Mishra
Background: As costs of cancer care rise, the importance of documenting value in oncology increases. Proton beam radiotherapy (PBT) has the potential to reduce toxicities in cancer patients, but is relatively expensive and unproven. Evaluating quality of life (QOL) and patient-reported outcomes (PROs) is essential to establishing PBT's "value" in oncologic therapy. The goal of this systematic review was to assess QOL and PROs in patients treated with PBT. Methods: Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-guided systematic searches were conducted...
April 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29026997/a-systematic-review-of-integrative-clinical-trials-for-supportive-care-in-pediatric-oncology-a-report-from-the-international-society-of-pediatric-oncology-t-cm-collaborative
#4
REVIEW
Andrea L Radossi, Katherine Taromina, Stacey Marjerrison, Caroline J Diorio, Raquel Similio, Festus Njuguna, Glenn M Afungchwi, Elena J Ladas
PURPOSE: Traditional and complementary medicine (T&CM) use in children with cancer is well established among high-income, upper middle-income, low-middle-income, and low-income countries (HIC, UMIC, LMIC, LIC, respectively). In HIC, a developing body of evidence exists for several T&CM therapies; however, evidence in other income settings is less well described despite a significantly higher use when compared to reports from HIC. The aim of this systematic review was to evaluate the evidence for T&CM for a variety of supportive care indications among children with cancer...
October 13, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29025266/the-abcs-of-immunotherapy-for-adult-patients-with-b-cell-acute-lymphoblastic-leukemia
#5
Troy Z Horvat, Amanda N Seddon, Adebayo Ogunniyi, Amber C King, Larry W Buie, Ryan J Daley
OBJECTIVE: To review the pharmacology, efficacy, and safety of Food and Drug Administration approved and promising immunotherapy agents used in the treatment of acute lymphoblastic leukemia (ALL). DATA SOURCES: A literature search was performed of PubMed and MEDLINE databases (1950 to July 2017) and of abstracts from the American Society of Hematology and the American Society of Clinical Oncology. Searches were performed utilizing the following key terms: rituximab, blinatumomab, inotuzumab, ofatumumab, obinutuzumab, Blincyto, Rituxan, Gazyva, Arzerra, CAR T-cell, and chimeric antigen receptor (CAR)...
October 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29022226/parents-and-physicians-perceptions-of-children-s-participation-in-decision-making-in-paediatric-oncology-a-quantitative-study
#6
Michael Rost, Tenzin Wangmo, Felix Niggli, Karin Hartmann, Heinz Hengartner, Marc Ansari, Pierluigi Brazzola, Johannes Rischewski, Maja Beck-Popovic, Thomas Kühne, Bernice S Elger
The goal is to present how shared decision-making in paediatric oncology occurs from the viewpoints of parents and physicians. Eight Swiss Pediatric Oncology Group centres participated in this prospective study. The sample comprised a parent and physician of the minor patient (<18 years). Surveys were statistically analysed by comparing physicians' and parents' perspectives and by evaluating factors associated with children's actual involvement. Perspectives of ninety-one parents and twenty physicians were obtained for 151 children...
October 11, 2017: Journal of Bioethical Inquiry
https://www.readbyqxmd.com/read/28992567/conditional-survival-of-pediatric-adolescent-and-young-adult-soft-tissue-sarcoma-and-bone-tumor-patients
#7
Judy Y Ou, Holly Spraker-Perlman, Andrew C Dietz, Rochelle R Smits-Seemann, Sapna Kaul, Anne C Kirchhoff
BACKGROUND: Survival estimates for soft tissue sarcomas (STS) and malignant bone tumors (BT) diagnosed in pediatric, adolescent, and young adult patients are not easily available. We present survival estimates based on a patient having survived a defined period of time (conditional survival). Conditional survival estimates for the short-term were calculated for patients from diagnosis to the first five years after diagnosis and for patients surviving in the long-term (up to 20 years after diagnosis)...
October 6, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28991126/successful-treatment-of-invasive-conidiobolus-infection-during-therapy-for-acute-lymphoblastic-leukemia
#8
Craig Erker, Anna R Huppler, Thomas J Walsh, Michael E McCormick, Mariko Suchi, Neel S Bhatt, Susan C Kehl, Jessica Southwood, Paul Harker-Murray
Invasive fungal infections are a serious cause of morbidity and mortality in patients with hematologic malignancies. Conidiobolus species are molds within the order Entomophthorales and may disseminate to become rapidly fatal in immunocompromised individuals. This species of fungal infections are often multidrug resistant (MDR) and present unique therapeutic challenges. Reports of Conidiobolus infections are rare in pediatric oncology. We report the successful treatment of an adolescent male with B-cell lymphoblastic leukemia and MDR invasive sinopulmonary Conidiobolus infection with emphasis on early and aggressive neutrophil support with surgical debridement...
October 5, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28990685/national-trends-in-otolaryngology-intern-curricula-following-accreditation-council-for-graduate-medical-education-changes
#9
Kevin J Kovatch, Rebecca S Harvey, Mark E P Prince, Marc C Thorne
OBJECTIVES/HYPOTHESIS: In 2016, Accreditation Council for Graduate Medical Education (ACGME) requirements for curriculum and resident experiences were modified to require entering postgraduate year (PGY)-1 residents to spend 6 months of structured education on otolaryngology-head and neck surgery (ORL-HNS) rotations. We aimed to determine how ORL-HNS training programs have adapted curricula in response to 2016 ACGME curriculum requirement changes. STUDY DESIGN: Survey study...
October 9, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28984677/advances-in-the-understanding-and-management-of-mucositis-during-stem-cell-transplantation
#10
Joanne M Bowen, Hannah R Wardill
PURPOSE OF REVIEW: Mucositis is a severe and common side effect of anticancer treatments, with an incidence of between 40 and 80% depending on the cytotoxic regimen used. The most profound mucositis burden is experienced during conditioning regimens for hematopoietic stem cell transplant (HSCT), where the use of highly mucotoxic agents with or without total body irradiation leads to serious damage throughout the alimentary tract. Currently, the assessment and management of both oral and gastrointestinal mucositis lack authoritative guideline, with recommendations only achieved in narrow clinical scenarios...
October 3, 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28984250/pediatric-rhabdomyosarcoma-in-india-a-single-center-experience
#11
Deepak Bansal, Anirban Das, Amita Trehan, Rakesh Kapoor, Naresh K Panda, Radhika Srinivasan, Naresh K Panda, Radhika Srinivasan, Nandita Kakkar, Kushaljit S Sodhi, Akshay K Saxena, Katragadda Lakshmi Narasimha Rao
OBJECTIVE: Analyze the profile and outcome of children with rhabdomyosarcoma from a pediatric-oncology unit. DESIGN: Retrospective analysis of case records over 23 years (1990-2012). Setting: Government-run, tertiary-care, university hospital in Northern India. PARTICIPANTS: 159 children (<12-years) with a diagnosis of rhabdomyosarcoma were enrolled. The median age was 4 years; 13% were infants. MAIN OUTCOME MEASURE: Five-year event free survival...
September 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28982637/pediatric-chronic-patients-at-outpatient-clinics-a-study-in-a-latin-american-university-hospital
#12
Renata A Alveno, Caroline V Miranda, Caroline G Passone, Aurora R Waetge, Elza S Hojo, Sylvia C L Farhat, Vicente Odone-Filho, Uenis Tannuri, Werther B Carvalho, Magda Carneiro-Sampaio, Clovis A Silva
OBJECTIVE: To describe the characteristics of children and adolescentes with chronic diseases of outpatient clinics at a tertiary university hospital. METHODS: A cross-sectional study was performed with 16,237 patients with chronic diseases followed-up in one year. The data were collected through the electronic system, according to the number of physician appointments in 23 pediatric specialties. Patients were divided in two groups: children (0-9 years) and adolescents (10-19 years)...
October 2, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28976795/prevalence-and-predictors-of-sperm-banking-in-adolescents-newly-diagnosed-with-cancer-examination-of-adolescent-parent-and-provider-factors-influencing-fertility-preservation-outcomes
#13
James L Klosky, Fang Wang, Kathryn M Russell, Hui Zhang, Jessica S Flynn, Lu Huang, Karen Wasilewski-Masker, Wendy Landier, Marcia Leonard, Karen H Albritton, Abha A Gupta, Jacqueline Casillas, Paul Colte, William H Kutteh, Leslie R Schover
Purpose To estimate the prevalence of sperm banking among adolescent males newly diagnosed with cancer and to identify factors associated with banking outcomes. Patients and Methods A prospective, single-group, observational study design was used to test the contribution of sociodemographic, medical, psychological/health belief, communication, and developmental factors to fertility preservation outcomes. At-risk adolescent males (N = 146; age 13.00 to 21.99 years; Tanner stage ≥ 3), their parents, and medical providers from eight leading pediatric oncology centers across the United States and Canada completed self-report questionnaires within 1 week of treatment initiation...
October 4, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28971174/investigation-of-celiac-disease-followed-by-immune-thrombocytopenic-purpura-diagnosis-in-patients-and-comparison-with-literature
#14
Hakan Sarbay, Halil Kocamaz, Mehmet Akin, Bayram Ozhan
OBJECTIVE: Celiac disease (CD) and Immune thrombocytopenic purpura (ITP) may occur together as a result of similar autoimmune mechanisms. The aim of this study was to assess the frequency of CD in a group of ITP patients and in the literature. METHODS: A total of 29 patients in Pamukkale University Faculty of Medicine Hospital Pediatric Hematology and Oncology Department with ITP were included in the study. Test was performed for the antibodies related to CD. Positive result for celiac antibodies was confirmed with biopsy...
2017: Northern Clinics of Istanbul
https://www.readbyqxmd.com/read/28969889/return-and-disclosure-of-research-results-parental-attitudes-and-needs-over-time-in-pediatric-oncology
#15
Imme Petersen, Peter Kaatsch, Claudia Spix, Regine Kollek
OBJECTIVES: To explore parental attitudes regarding the return and disclosure of research findings in pediatric cancer trials over time. STUDY DESIGN: Two surveys were set up to evaluate the stability of parental attitudes. One survey was carried out among 581 parents whose child was diagnosed recently (response rate, 53.5%). A second, population-based survey was set up with a time interval of 4 years between first cancer diagnosis and survey in which 1465 parents were included (response rate, 55...
September 29, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28968170/broadening-eligibility-criteria-to-make-clinical-trials-more-representative-american-society-of-clinical-oncology-and-friends-of-cancer-research-joint-research-statement
#16
Edward S Kim, Suanna S Bruinooge, Samantha Roberts, Gwynn Ison, Nancy U Lin, Lia Gore, Thomas S Uldrick, Stuart M Lichtman, Nancy Roach, Julia A Beaver, Rajeshwari Sridhara, Paul J Hesketh, Andrea M Denicoff, Elizabeth Garrett-Mayer, Eric Rubin, Pratik Multani, Tatiana M Prowell, Caroline Schenkel, Marina Kozak, Jeff Allen, Ellen Sigal, Richard L Schilsky
Purpose The primary purposes of eligibility criteria are to protect the safety of trial participants and define the trial population. Excessive or overly restrictive eligibility criteria can slow trial accrual, jeopardize the generalizability of results, and limit understanding of the intervention's benefit-risk profile. Methods ASCO, Friends of Cancer Research, and the US Food and Drug Administration examined specific eligibility criteria (ie, brain metastases, minimum age, HIV infection, and organ dysfunction and prior and concurrent malignancies) to determine whether to modify definitions to extend trials to a broader population...
October 2, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28968169/modernizing-clinical-trial-eligibility-recommendations-of-the-american-society-of-clinical-oncology-friends-of-cancer-research-minimum-age-working-group
#17
Lia Gore, S Percy Ivy, Frank M Balis, Eric Rubin, Katherine Thornton, Martha Donoghue, Samantha Roberts, Suanna Bruinooge, Jennifer Ersek, Nancy Goodman, Caroline Schenkel, Gregory Reaman
Purpose Children have historically been excluded from first-in-human studies of promising new cancer drugs and later phase adult clinical trials. Delays in evaluation may result in off-label use without dosing information as the only access to new drugs. A multistakeholder workshop was convened in May 2016 by ASCO and Friends of Cancer Research to identify opportunities for when it would be scientifically appropriate to expand trial eligibility to include children younger than age 18 years in first-in-human and other adult cancer clinical trials...
October 2, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28963046/introducing-a-simple-method-of-maxillary-sinus-volume-assessment-based-on-linear-dimensions
#18
Agnieszka Przystańska, Tomasz Kulczyk, Artur Rewekant, Alicja Sroka, Katarzyna Jończyk-Potoczna, Dorota Lorkiewicz-Muszyńska, Krzysztof Gawriołek, Agata Czajka-Jakubowska
Measuring sinus volume in a general practice clinic is a complex and time-consuming procedure, requiring experience in the use of radiological methods In the presented research, the automatically estimated maxillary sinus volume was compared with maxillary sinus volume assessed with mathematical formulas used to calculate the volume of spheres and pyramids. The starting point for the statistical analysis were specific measurements of the sinuses. We wanted to discover which geometric shape has the volume that is nearest to the automatically estimated volume...
September 28, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28960796/microbiological-profile-and-nutritional-quality-of-a-regular-diet-compared-to-a-neutropenic-diet-in-a-pediatric-oncology-unit
#19
Juliana Elert Maia, Luciane Beitler da Cruz, Lauro José Gregianin
It has been hypothesized that a neutropenic diet has lower microbe content. Here, the microbiological and nutritional contents of regular and neutropenic diets offered to pediatric patients were analyzed. Microbiological contamination was detected in five of 36 of the food samples analyzed, yet there was no statistical differences between the diets (P = 1.00) or in their odds ratio (0.62) (95% CI = 0.05-6.35; P = 0.63). The strict neutropenic diet did have less fiber (P = 0.05) and vitamin C (P = 0...
September 27, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28960700/predictors-of-treatment-abandonment-for-patients-with-pediatric-cancer-at-indus-children-cancer-hospital-karachi-pakistan
#20
Durr-E-Fatima Siddiqui, Muhammad Shamvil Ashraf, Sundus Iftikhar, Asim F Belgaumi
BACKGROUND: Abandonment of treatment is one of the toughest challenges to deal with in pediatric oncology. It leads to unnecessary mortality and morbidity in patients from low- and middle-income countries. PROCEDURE: The objective of our retrospective study was to determine the prevalence and predictors for abandonment among children with cancer at our hospital in Karachi, Pakistan. We analyzed data on patients younger than 18 years, diagnosed with any malignancy between November 2014 and May 2016...
September 27, 2017: Pediatric Blood & Cancer
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