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Pediatric oncology

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https://www.readbyqxmd.com/read/29470703/guide-for-health-professionals-addressing-oral-care-for-individuals-in-oncological-treatment-based-on-scientific-evidence
#1
Caroline Gomes Carvalho, João Batista Medeiros-Filho, Meire Coelho Ferreira
OBJECTIVE: Oncological treatment can cause changes in the oral cavity compromising oral functions. The aim of the study was, based on a systematic review, to draft a guide directed at the team of health professionals involved in the oral care of oncological patients. METHODS: A systematic search of the literature was performed for articles published between 2000 and April 2017. Searches were made of electronic databases and hand search. The inclusion criteria were systematic reviews of randomized clinical trials (RCTs) and RCTs published in English, involving pediatric and adult oncological patients and focused on the prevention and treatment of oral complications as well as studies addressing the maintenance of oral health...
February 22, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29468476/current-treatment-of-pediatric-bladder-and-prostate-rhabdomyosarcoma
#2
REVIEW
Amanda F Saltzman, Nicholas G Cost
PURPOSE OF REVIEW: Rhabdomyosarcoma (RMS) is the most common sarcoma diagnosed in the first 20 years of life; bladder/prostate (BP) RMS accounts for 5% of all cases. Through efforts from multiple cooperative study groups, survival has improved significantly. This article aims to review the complex RMS classification system and treatment of BP RMS, with a focus on developing aspects of treatment. RECENT FINDINGS: Recent advancements in technology are responsible for most of the progress in RMS treatment...
February 22, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/29462168/risk-and-surrogate-benefit-for-pediatric-phase-i-trials-in-oncology-a-systematic-review-with-meta-analysis
#3
Marcin Waligora, Malgorzata M Bala, Magdalena Koperny, Mateusz T Wasylewski, Karolina Strzebonska, Rafał R Jaeschke, Agnieszka Wozniak, Jan Piasecki, Agnieszka Sliwka, Jerzy W Mitus, Maciej Polak, Dominika Nowis, Dean Fergusson, Jonathan Kimmelman
BACKGROUND: Pediatric Phase I cancer trials are critical for establishing the safety and dosing of anti-cancer treatments in children. Their implementation, however, must contend with the rarity of many pediatric cancers and limits on allowable risk in minors. The aim of this study is to describe the risk and benefit for pediatric cancer Phase I trials. METHODS AND FINDINGS: Our protocol was prospectively registered in PROSPERO (CRD42015015961). We systematically searched Embase and PubMed for solid and hematological malignancy Phase I pediatric trials published between 1 January 2004 and 1 March 2015...
February 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29461749/-persistant-fevers-of-infectious-origin-in-children
#4
Marie Rohr, Noémie Wagner
Prolonged fevers in children are a regular challenge for the paediatrician or any physician caring for these children (emergency physicians, pediatric infectious diseases specialists). The causes are multiple, classified into three major families : infectious, inflammatory and oncological. Infectious causes are the most common and account for more than 50 % of cases. The objective of this review is to guide physicians in charge of these patients throughout their management by focusing on the quest of infectious causes...
February 14, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29461635/clinical-and-mutational-spectrum-of-highly-differentiated-paired-box-3-forkhead-box-protein-o1-fusion-negative-rhabdomyosarcoma-a-report-from-the-children-s-oncology-group
#5
Lisa A Teot, Michaela Schneider, Aaron R Thorner, Jing Tian, Yueh-Yun Chi, Matthew Ducar, Ling Lin, Marcin Wlodarski, Holcombe E Grier, Christopher D M Fletcher, Paul van Hummelen, Stephen X Skapek, Douglas S Hawkins, Amy J Wagers, Carlos Rodriguez-Galindo, Simone Hettmer
BACKGROUND: Pediatric paired box 3:forkhead box protein O1 fusion-negative (PF-) rhabdomyosarcoma (RMS) represents a diverse spectrum of tumors with marked differences in histology, myogenic differentiation, and clinical behavior. METHODS: This study sought to evaluate the clinical and mutational spectrum of 24 pediatric PF- human RMS tumors with high levels of myogenic differentiation. Tumors were sequenced with OncoPanel v.2, a panel consisting of the coding regions of 504 genes previously linked to human cancer...
February 20, 2018: Cancer
https://www.readbyqxmd.com/read/29459598/abandonment-and-outcome-of-childhood-acute-myeloid-leukemia-in-a-tertiary-level-hospital
#6
M Begum, A Islam, A A Rahman, M Akter, S T Alam, R Tasmeen
Acute leukemias are the most common child hood malignancy, of which acute myeloid leukemia (AML) are 15 to 20%. Abandonment is one of the most important causes of treatment failure in AML in developing countries. Lost to follow-up is also a big problem in low income countries. Many patients stop therapy soon after diagnosis due to cost, distance and ignorance. To determine the abandonment, outcome and treatment related mortality (TRM) and morbidity among children with AML. This prospective observational study was conducted in the Department of Pediatric hematology and Oncology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from February 2013 to January 2014...
January 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29455939/strategies-to-facilitate-shared-decision-making-about-pediatric-oncology-clinical-trial-enrollment-a-systematic-review
#7
REVIEW
Eden G Robertson, Claire E Wakefield, Christina Signorelli, Richard J Cohn, Andrea Patenaude, Claire Foster, Tristan Pettit, Joanna E Fardell
OBJECTIVE: We conducted a systematic review to identify the strategies that have been recommended in the literature to facilitate shared decision-making regarding enrolment in pediatric oncology clinical trials. METHODS: We searched seven databases for peer-reviewed literature, published 1990-2017. Of 924 articles identified, 17 studies were eligible for the review. We assessed study quality using the 'Mixed-Methods Appraisal Tool'. We coded the results and discussions of papers line-by-line using nVivo software...
February 11, 2018: Patient Education and Counseling
https://www.readbyqxmd.com/read/29453505/does-hope-matter-associations-among-self-reported-hope-anxiety-and-health-related-quality-of-life-in-children-and-adolescents-with-cancer
#8
Ana Rita Martins, Carla Crespo, Ágata Salvador, Susana Santos, Carlos Carona, Maria Cristina Canavarro
This study aimed to examine the direct and indirect effects of hope on health-related quality of life (HRQoL) via anxiety of children/adolescents with cancer. We proposed to test if the mediation model was moderated by the child/adolescent's treatment status. The participants were 211 children/adolescents diagnosed with cancer, divided into two clinical groups according to treatment status: 97 patients on-treatment and 114 off-treatment. Self-reported questionnaires measured the youths' hope, anxiety, and HRQoL perceptions...
February 16, 2018: Journal of Clinical Psychology in Medical Settings
https://www.readbyqxmd.com/read/29452875/use-of-expanders-for-bowel-protection-in-pediatric-pelvic-tumor-radiation-therapy-15-years-of-tolerance-results
#9
Fernand Missohou
PURPOSE: Bowel is often the dose-limiting organ in curative pelvic irradiation because of radiation enteritis when dose exceeds 40 to 45 Gy. To limit radiation enteritis, a silicone tissue-expander prothesis (STEP) connected to a subcutaneous self-sealing valve was prospectively used in children undergoing pelvic or abdominal radiation therapy. This study reports the 15-year long-term outcomes of this prospective series. METHODS AND MATERIALS: Between 1987 and 2008, 29 children from 3 Paris institutions received pelvic radiation therapy after surgical placement of a STEP in the pelvis...
December 14, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29451689/barriers-to-accessing-palliative-care-for-pediatric-patients-with-cancer-a-review-of-the-literature
#10
REVIEW
Emily R Haines, A Corey Frost, Heather L Kane, Franziska S Rokoske
Although many of the 16,000 children in the United States diagnosed who are with cancer each year could benefit from pediatric palliative care, these services remain underused. Evidence regarding the barriers impeding access to comprehensive palliative care is dispersed in the literature, and evidence specific to pediatric oncology remains particularly sparse. The purpose of the current review was to synthesize the existing literature regarding these barriers and the strategies offered to address them. The authors completed a literature search using the PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Web of Science databases...
February 16, 2018: Cancer
https://www.readbyqxmd.com/read/29451420/integration-of-clinical-pharmacists-into-an-ambulatory-pediatric-hematology-oncology-transplant-clinic
#11
Kimberly D Defoe, Jennifer Jupp, Tara Leslie
Objectives To describe key activities performed by a newly deployed clinical pharmacist in an outpatient pediatric hematology, oncology, transplant clinic. To demonstrate how utilization of the pharmacist evolved, as indicated by changes in frequency of key activities, during the first four months of integration. Design Clinical pharmacists were made consistently available in an outpatient clinic serving hematology, oncology, transplant patients and their families. A list of key activities, based on provincial clinical pharmacist standards, was created to provide a framework for the role...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29449938/molecular-characteristics-and-successful-management-of-a-respiratory-syncytial-virus-outbreak-among-pediatric-patients-with-hemato-oncological-disease
#12
Claas Baier, Sibylle Haid, Andreas Beilken, Astrid Behnert, Martin Wetzke, Richard J P Brown, Corinna Schmitt, Ella Ebadi, Gesine Hansen, Thomas F Schulz, Thomas Pietschmann, Franz-Christoph Bange
Background: Respiratory syncytial virus (RSV) is responsible for upper and lower respiratory tract infection in adults and children. Especially immunocompromised patients are at high risk for a severe course of infection, and mortality is increased. Moreover RSV can spread in healthcare settings and can cause outbreaks. Herein we demonstrate the successful control and characteristics of a RSV outbreak that included 8 patients in our Department of Pediatric Hematology and Oncology. Methods: We performed an epidemiologic investigation and a molecular analysis of the outbreak strains...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29448858/long-term-results-of-the-aieop-mh-96-childhood-hodgkin-s-lymphoma-trial-and-focus-on-significance-of-response-to-chemotherapy-and-its-implication-in-low-risk-patients-to-avoid-radiotherapy
#13
Roberta Burnelli, Simona Rinieri, Roberto Rondelli, Alessandra Todesco, Maurizio Bianchi, Alberto Garaventa, Marco Zecca, Paolo Indolfi, Valentino Conter, Nicola Santoro, Maurizio Aricò, Simone Cesaro, Salvatore D'amico, Piero Farruggia, Raffaela De Santis, Franco Locatelli, Stefano A Pileri, Giovanni Scarzello, Maurizio Mascarin, Vico Vecchi
Identify a subset of early-stage HL children (GR1) curable with limited chemotherapy+/-radiotherapy; improve outcome of intermediate (GR2) and high-risk (GR3) patients; establish impact of response to chemotherapy evaluated with conventional imaging (CI). One hundred and sixty GR1-patients received 3ABVD + involved-field (IF) low-dose (LD) (20 Gy) irradiation if mediastinal mass or partial response (PR) after chemotherapy. Eighty-five GR2- and 315 GR3-patients received 4 and 6 COPP/ABV + IFRT, respectively...
February 16, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29443850/does-an-algorithmic-approach-to-using-brachytherapy-and-external-beam-radiation-result-in-good-function-local-control-rates-and-low-morbidity-in-patients-with-extremity-soft-tissue-sarcoma
#14
Jason Klein, Alex Ghasem, Samuel Huntley, Nathan Donaldson, Martin Keisch, Sheila Conway
BACKGROUND: High-dose-rate brachytherapy (HDR-BT) and external-beam radiation therapy (EBRT) are two modalities used in the treatment of soft tissue sarcoma. Previous work at our institution showed early complications and outcomes for patients treated with HDR-BT, EBRT, or a combination of both radiation therapy modalities. As the general indications for each of these approaches to radiation therapy differ, it is important to evaluate the use of each in an algorithmic way, reflecting how they are used in contemporary practice at sites that use these treatments...
March 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29442287/recent-developments-in-adolescent-and-young-adult-aya-acute-lymphoblastic-leukemia
#15
REVIEW
Victor M Orellana-Noia, Michael G Douvas
PURPOSE OF REVIEW: Adolescent and Young Adult (AYA) Oncology is a relatively new field encompassing research in the unique pathophysiology, clinical care, and psychosocial issues facing patients between the ages of 15 and 40 with cancer. About 100,000 of the approximately 1.5 million people diagnosed annually with cancer in the USA are in this age range. This chapter will review notable new developments in the care of adolescents and young adults with acute lymphoblastic leukemia (ALL) within the last 3 years...
February 14, 2018: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/29434493/comparative-study-of-complications-in-cv-catheter-insertion-for-pediatric-patients-real-time-ultrasound-guided-versus-venography-guided-approach
#16
Shuichi Takano, Norio Shimizu, Naruo Tokuyasu, Teruhisa Sakamoto, Soichiro Honjo, Keigo Ashida, Hiroaki Saito, Yoshiyuki Fujiwara
Background: Tunneled central venous catheters (CVC), called Broviac/Hickman catheter, are widely used in the long-term treatment of pediatric patients. Recently, the percutaneous approach for CVC insertion has become dominant as a less invasive intervention. In this study, we reviewed the mechanical and delayed complications according to different procedures of CVC insertion and assessed the risk factors for complications in CVC insertions for pediatric patients. Methods: A total of 159 pediatric patients (85 males and 74 females) were included in this study...
December 2017: Yonago Acta Medica
https://www.readbyqxmd.com/read/29431566/levocarnitine-for-asparaginase-induced-hepatic-injury-a-multi-institutional-case-series-and-review-of-the-literature
#17
Rachael R Schulte, Manasi V Madiwale, Allyson Flower, Jessica Hochberg, Michael J Burke, Jennifer L McNeer, Adam DuVall, Archie Bleyer
Asparaginase, an important treatment component for acute lymphoblastic leukemia (ALL), causes severe hepatotoxicity in some patients. Levocarnitine is a mitochondrial co-factor that can potentially ameliorate the mitochondrial toxicity of asparaginase. In this retrospective case series, we describe the clinical presentation and management of six pediatric and young adult patients (mean age 12.7, range 9-24 years) with ALL who developed Grade 3-4 hyperbilirubinemia following administration of asparaginase as part of induction/re-induction therapy...
February 12, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29431252/factors-associated-with-abandonment-of-therapy-by-children-diagnosed-with-solid-tumors-in-peru
#18
Liliana Vasquez, Rosdali Diaz, Sharon Chavez, Fanny Tarrillo, Ivan Maza, Eddy Hernandez, Monica Oscanoa, Juan García, Jenny Geronimo, Nuria Rossell
BACKGROUND: Abandonment of treatment is a major cause of treatment failure and poor survival in children with cancer in low- and middle-income countries. The incidence of treatment abandonment in Peru has not been reported. The aim of this study was to examine the prevalence of and factors associated with treatment abandonment by pediatric patients with solid tumors in Peru. METHODS: We retrospectively reviewed the sociodemographic and clinical data of children referred between January 2012 and December 2014 to the two main tertiary centers for childhood cancer in Peru...
February 12, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29427028/2017-pretext-radiologic-staging-system-for-primary-hepatic-malignancies-of-childhood-revised-for-the-paediatric-hepatic-international-tumour-trial-phitt
#19
REVIEW
Alexander J Towbin, Rebecka L Meyers, Helen Woodley, Osamu Miyazaki, Christopher B Weldon, Bruce Morland, Eiso Hiyama, Piotr Czauderna, Derek J Roebuck, Greg M Tiao
Imaging is crucial in the assessment of children with a primary hepatic malignancy. Since its inception in 1992, the PRETEXT (PRE-Treatment EXTent of tumor) system has become the primary method of risk stratification for hepatoblastoma and pediatric hepatocellular carcinoma in numerous cooperative group trials across the world. The PRETEXT system is made of two components: the PRETEXT group and the annotation factors. The PRETEXT group describes the extent of tumor within the liver while the annotation factors help to describe associated features such as vascular involvement (either portal vein or hepatic vein/inferior vena cava), extrahepatic disease, multifocality, tumor rupture and metastatic disease (to both the lungs and lymph nodes)...
February 9, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29425881/pediatric-oncology-provider-perceptions-of-a-pediatric-palliative-care-service-the-influence-of-emotional-esteem-and-emotional-labor
#20
Julia E Szymczak, Theodore Schall, Douglas L Hill, Jennifer K Walter, Shefali Parikh, Concetta DiDomenico, Chris Feudtner
CONTEXT: Pediatric palliative care consults for children with cancer often occur late in the course of disease and close to death, when earlier involvement would reduce suffering. The perceptions that pediatric oncology providers hold about the pediatric palliative care service (PPCS) may shape referral patterns. OBJECTIVE: To explore how pediatric oncology providers at one institution perceived the hospital's PPCS and the way these perceptions may influence the timing of consultation...
February 6, 2018: Journal of Pain and Symptom Management
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