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https://www.readbyqxmd.com/read/28337194/il-1%C3%AE-il-8-and-matrix-metalloproteinases-1-2-and-10-are-enriched-upon-monocyte-breast-cancer-cell-cocultivation-in-a-matrigel-based-three-dimensional-system
#1
Nancy Adriana Espinoza-Sánchez, Gloria Karina Chimal-Ramírez, Alejandra Mantilla, Ezequiel Moisés Fuentes-Pananá
Breast cancer remains the first cancer-related cause of death in women worldwide, particularly in developing countries in which most cases are diagnosed in late stages. Although most cancer studies are based in the genetic or epigenetic changes of the tumor cells, immune cells within the tumor stroma often cooperate with cancer progression. Particularly, monocytes are attracted to the tumor primary site in which they are differentiated into tumor-associated macrophages that facilitate tumor cell invasion and metastasis...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28333265/improving-oocyte-quality-by-transfer-of-autologous-mitochondria-from-fully-grown-oocytes
#2
Stine Gry Kristensen, Susanne Elisabeth Pors, Claus Yding Andersen
Older women are often the most challenging group of patients in fertility clinics due to a decline in both number and overall quality of oocytes. The quality of oocytes has been linked to mitochondrial dysfunction. In this mini-review, we discuss this hypothesis and suggest alternative treatment options using autologous mitochondria to potentially augment pregnancy potential in ART. Autologous transfer of mitochondria from the patient's own germline cells has attracted much attention as a possible new treatment to revitalize deficient oocytes...
March 2, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28327251/attentional-and-affective-biases-for-attractive-females-emerge-early-in-development
#3
Jennifer Lynn Rennels, Stephanie Ann Verba
Predominant experience with females early in development results in infants developing an attractive, female-like facial representation that guides children's attention toward and affective preferences for attractive females. When combined with increased interest in the other sex at puberty, these early emerging biases might help explain the robust prosocial and financial biases men exhibit toward attractive women during adulthood.
January 2017: Behavioral and Brain Sciences
https://www.readbyqxmd.com/read/28326892/clinical-and-histomorphometric-assessment-of-lateral-alveolar-ridge-augmentation-using-a-corticocancellous-freeze-dried-allograft-bone-block
#4
Roya Shariatmadar Ahmadi, Ferena Sayar, Vahid Rakhshan, Babak Iranpour, Jahanfar Jahanbani, Ahmad Toumaj, Nasrin Akhoondi
Horizontal ridge augmentation with allografts has attracted notable attention because of its proper success rate and the lack of disadvantages of autografts. Corticocancellous block allografts have not been adequately studied on humans. Therefore, this study evaluated clinically and histomorphometrically the increase in ridge with after horizontal ridge augmentation using corticocancellous block allografts, and the implant success after 12 to 18 months post-implantation. In 10 implant patients (3 women, 7 men, 45 years old on average), defective maxillary alveolar ridges were horizontally augmented using freeze-dried bone allograft blocks...
March 22, 2017: Journal of Oral Implantology
https://www.readbyqxmd.com/read/28325109/feasibility-and-effects-of-a-combined-adjuvant-high-intensity-interval-strength-training-in-breast-cancer-patients-a-single-center-pilot-study
#5
Sebastian Viktor Waldemar Schulz, Roman Laszlo, Stephanie Otto, Dmytro Prokopchuk, Uwe Schumann, Florian Ebner, Jens Huober, Jürgen Michael Steinacker
PURPOSE: To evaluate feasibility of an exercise intervention consisting of high-intensity interval endurance and strength training in breast cancer patients. METHODS: Twenty-six women with nonmetastatic breast cancer were consecutively assigned to the exercise intervention- (n= 15, mean age 51.9 ± 9.8 years) and the control group (n = 11, mean age 56.9 ± 7.0 years). Cardiopulmonary exercise testing that included lactate sampling, one-repetition maximum tests and a HADS-D questionnaire were used to monitor patients both before and after a supervised six weeks period of either combined high-intensity interval endurance and strength training (intervention group, twice a week) or leisure training (control group)...
March 21, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28318681/updated-recommendations-on-the-use-of-hydroxychloroquine-in-dermatologic-practice
#6
REVIEW
Anthony P Fernandez
Hydroxychloroquine has unique immunomodulatory properties and an attractive adverse effect profile. Over the past 10 years, research has led to significant updates in clinical recommendations concerning the optimal use of hydroxychloroquine and monitoring of patients taking it. We discuss updated recommendations concerning hydroxychloroquine daily dosing, retinopathy screening, serologic monitoring, use in smokers, use in pregnant women, and adverse effect risk and monitoring. This review can hopefully serve as an aid to dermatologists and help ensure they continue using hydroxychloroquine safely and effectively...
March 16, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28315307/no-compelling-positive-association-between-ovarian-hormones-and-wearing-red-clothing-when-using-multinomial-analyses
#7
Khandis R Blake, Barnaby J W Dixson, Siobhan M O'Dean, Thomas F Denson
Several studies report that wearing red clothing enhances women's attractiveness and signals sexual proceptivity to men. The associated hypothesis that women will choose to wear red clothing when fertility is highest, however, has received mixed support from empirical studies. One possible cause of these mixed findings may be methodological. The current study aimed to replicate recent findings suggesting a positive association between hormonal profiles associated with high fertility (high estradiol to progesterone ratios) and the likelihood of wearing red...
March 20, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28315140/electrophysiological-evidence-of-perceived-sexual-attractiveness-for-human-female-bodies-varying-in-waist-to-hip-ratio
#8
Marzia Del Zotto, Alan J Pegna
The dynamics of brain activation reflecting attractiveness in humans are unclear. Among the different features affecting attractiveness of the female body, the waist-to-hip ratio (WHR) is considered to be crucial. To date, however, no event-related potential (ERP) study has addressed the question of its associated pattern of brain activation. We carried out two different experiments: (a) a behavioural study, to judge the level of attractiveness of female realistic models depicting 4 different WHRs (0.6, 0.7, 0...
March 17, 2017: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/28314835/endocrine-therapy-in-the-current-management-of-postmenopausal-estrogen-receptor-positive-metastatic-breast-cancer
#9
Virginia G Kaklamani, William J Gradishar
Metastatic breast cancer (MBC) results in substantial morbidity and mortality for women afflicted with this disease. A majority of MBCs are hormone-responsive and estrogen receptor-positive, making endocrine therapy (ET) an integral component of systemic therapy. With a primary goal of minimizing the effects of estrogen on hormone-responsive MBC, ETs are among the first targeted treatments that aim to inhibit the influence of estrogen receptor activation on tumor proliferation. Several biochemical mechanisms have been the focus of drug development for treatment, including selective estrogen-receptor modulation, aromatase inhibition, and selective estrogen-receptor degradation...
March 17, 2017: Oncologist
https://www.readbyqxmd.com/read/28306561/diving-into-the-oocyte-pool
#10
Stine G Kristensen, Susanne E Pors, Claus Y Andersen
PURPOSE OF REVIEW: The ovarian reserve comprises an enormous surplus of follicles. Despite this, some women produce insufficient numbers of oocytes by conventional fertility treatments. However, recent technical accomplishments may transform assisted reproductive technology (ART) in such a way that oocytes are not necessarily the limiting factor. In this review, we present possible new strategies for enhancing the quantity of mature oocytes, and current views on autologous oocytes as potential sources of mitochondria to lift performance of compromised oocytes...
March 16, 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28301645/association-of-face-lift-surgery-with-social-perception-age-attractiveness-health-and-success
#11
Jason C Nellis, Masaru Ishii, Ira D Papel, Theda C Kontis, Patrick J Byrne, Kofi D O Boahene, Kristin L Bater, Lisa E Ishii
Importance: Evidence quantifying the influence of face-lift surgery on societal perceptions is lacking. Objective: To measure the association of face-lift surgery with observer-graded perceived age, attractiveness, success, and overall health. Design, Setting, and Participants: In a web-based survey, 526 casual observers naive to the purpose of the study viewed independent images of 13 unique female patient faces before or after face-lift surgery from January 1, 2016, through June 30, 2016...
March 16, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28300484/factors-associated-with-general-and-health-related-quality-of-life-in-menopausal-transition-among-women-from-serbia
#12
Jelena Dotlic, Ilma Kurtagic, Selmina Nurkovic, Nikolina Kovacevic, Sanja Radovanovic, Biljana Rancic, Branislav Milosevic, Milan Terzic, Tatjana Gazibara
This study assessed factors associated with quality of life (QOL) among Serbian peri- and postmenopausal women using two menopause-specific scales. This cross-sectional study included 500 women aged 40-65 years who had a gynecologic check-up in one of two Community Health Centers in Belgrade during February 2014 to January 2015. Women completed: a questionnaire about socio-demographics, habits and health status; a menopause-specific questionnaire, Utian's Quality of Life Scale (UQOL); a Women's Health Questionnaire (WHQ) and Beck's Depression Inventory (BDI)...
March 16, 2017: Women & Health
https://www.readbyqxmd.com/read/28300033/-current-status-of-extracorporeal-shock-wave-lithotripsy-in-urinary-lithiasis
#13
Jose Gregorio Pereira-Arias, Mikel Gamarra-Quintanilla, Luis Felipe Urdaneta-Salegui, Jorge Alberto Mora-Christian, Andrea Sánchez-Vazquez, Ander Astobieta-Odriozola, Gaspar Ibarluzea-González
Over the last decade, urinary lithiasis' prevalence has dramatically increased due to diet and lifestyle changes, growing 10.6% and 7.1% in men and women respectively. Extracorporeal shock wave lithotripsy has lost relevance in current practice due to endoscopic device development and unpredictability of results. Instrument miniaturization is leading to an increase of the percutaneous approach of increasingly smaller stones, while most flexible ureteroscopes durability and digitalization has allowed urologists to address larger stones...
March 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28293621/development-of-the-physical-activity-and-your-nutrition-for-cancer-pync-smartphone-app-for-preventing-breast-cancer-in-women
#14
Steven S Coughlin, Gina M Besenyi, Deborah Bowen, Gianluca De Leo
BACKGROUND: In the U.S., breast cancer accounts for more cancer deaths in women than any site other than lung cancer. Based upon attributable risks, about 30-35% of breast cancers could potentially be prevented by addressing obesity, physical inactivity, increased alcohol consumption, and carcinogenic exposures such as hormone replacement therapy (HRT). We need methods of reducing women's risks of this disease that are attractive and easy to use, widely accessible to diverse women, and able to be easily amended to account for new research...
2017: MHealth
https://www.readbyqxmd.com/read/28285543/feelings-of-unattractiveness-in-peri-and-postmenopausal-women-are-associated-with-depressed-mood-poor-memory-and-unsatisfactory-sexual-relationships
#15
M Terauchi, A Hirose, M Akiyoshi, K Kato, N Miyasaka
OBJECTIVES: This study aimed to investigate the prevalence of, and risk factors associated with, the feeling of unattractiveness in peri- and postmenopausal women. METHODS: The records of 351 women aged 40-76 who enrolled in a health and nutrition education program at a menopause clinic were analyzed in a cross-sectional manner. Perceptions of unattractiveness were estimated according to responses for the item 'feeling less attractive than before' on the Menopausal Health-Related Quality of Life Questionnaire...
March 11, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28284146/how-do-i-look-self-focused-attention-during-a-video-chat-of-women-with-social-anxiety-disorder
#16
Noortje Vriends, Yasemin Meral, Javier A Bargas-Avila, Christina Stadler, Susan M Bögels
We investigated the role of self-focused attention (SFA) in social anxiety (disorder) in an ecologically valid way. In Experiment 1 high (n = 26) versus low (n = 25) socially anxious single women between 18 and 30 years had a video ("Skype") conversation with an attractive male confederate, while seeing themselves and the confederate on-screen. The conversation was divided in four phases: (I) warm-up, (II) positive (confederate was friendly to the participant), (III) critical (confederate was critical to the participant), and (IV) active (participant was instructed to ask questions to the confederate)...
March 3, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28276934/do-women-s-orgasms-function-as-a-masculinity-achievement-for-men
#17
Sara B Chadwick, Sari M van Anders
Orgasms have been promoted as symbols of sexual fulfillment for women, and have perhaps become the symbol of a woman's healthy sex life. However, some research has suggested that this focus on women's orgasms, though ostensibly for women, may actually serve men; but the mechanisms of this are unclear. In the present experiment, we hypothesized that women's orgasms specifically function as a masculinity achievement for men. To test this, we randomly assigned 810 men (M age = 25.44, SD = 8.31) to read a vignette where they imagined that an attractive woman either did or did not orgasm during a sexual encounter with them...
February 23, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/28275673/insulin-secretagogue-use-and-circulating-inflammatory-c-c-chemokine-levels-in-breast-cancer-patients
#18
Zachary A P Wintrob, Jeffrey P Hammel, George K Nimako, Zahra S Fayazi, Dan P Gaile, Alan Forrest, Alice C Ceacareanu
Monocytes' infiltration into the tumor tissue and their activation to tumor-associated macrophages is an essential step in tumor development, also playing a critical role in an eventual metastasis. Stimulation of endogenous insulin production by oral insulin secretagogue treatment has the potential to interfere with the production and release of C-C chemokines, a group of potent inflammatory cytokines acting as monocyte chemo-attractants and influencing their behavior in the tumor microenvironment. Studied plasma samples were collected under a previously reported study design involving a population of women diagnosed with breast cancer presenting with or without type 2 diabetes mellitus at the time of breast cancer diagnosis (Wintrob et al...
April 2017: Data in Brief
https://www.readbyqxmd.com/read/28272905/g-protein-coupled-receptor-55-gpr55-expresses-differently-in-patients-with-crohn-s-disease-and-ulcerative-colitis
#19
Marcin Włodarczyk, Aleksandra Sobolewska-Włodarczyk, Adam I Cygankiewicz, Damian Jacenik, Wanda M Krajewska, Krystyna Stec-Michalska, Aleksandra Piechota-Polańczyk, Maria Wiśniewska-Jarosińska, Jakub Fichna
AIM: To investigate the levels of G protein-coupled receptor 55 (GPR55) expression in colonic tissue of inflammatory bowel disease (IBD) patients and healthy controls, and its potential implication in IBD treatment. METHODS: Fifty patients were enrolled in our prospective study: n = 21 with Crohn's disease (CD) and n = 16 with ulcerative colitis (UC); 19 women and 18 men. Control consisted of 13 non-IBD patients. In each subject, two biopsies were taken from different colonic locations...
March 8, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28267467/anemia-is-associated-with-bleeding-and-mortality-but-not-stroke-in-patients-with-atrial-fibrillation-insights-from-the-apixaban-for-reduction-in-stroke-and-other-thromboembolic-events-in-atrial-fibrillation-aristotle-trial
#20
B Daan Westenbrink, Marco Alings, Christopher B Granger, John H Alexander, Renato D Lopes, Elaine M Hylek, Laine Thomas, Daniel M Wojdyla, Michael Hanna, Matyas Keltai, P Gabriel Steg, Raffaele De Caterina, Lars Wallentin, Wiek H van Gilst
BACKGROUND: Patients with atrial fibrillation (AF) are prone to cardiovascular events and anticoagulation-related bleeding complications. We hypothesized that patients with anemia are at increased risk for these outcomes. METHODS: We performed a post hoc analysis of the ARISTOTLE trial, which included >18,000 patients with AF randomized to warfarin (target international normalized ratio, 2.0-3.0) or apixaban 5 mg twice daily. Multivariable Cox regression analysis was used to determine if anemia (defined as hemoglobin <13...
March 2017: American Heart Journal
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