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https://www.readbyqxmd.com/read/28185727/quantitative-investigation-of-the-mechanisms-of-microplastics-and-nanoplastics-toward-zebrafish-larvae-locomotor-activity
#1
Qiqing Chen, Michael Gundlach, Shouye Yang, Jing Jiang, Mirna Velki, Daqiang Yin, Henner Hollert
This study investigated the direct and indirect toxic effects of microplastics and nanoplastics toward zebrafish (Danio rerio) larvae locomotor activity. Results showed that microplastics alone exhibited no significant effects except for the upregulated zfrho visual gene expression; whereas nanoplastics inhibited the larval locomotion by 22% during the last darkness period, and significantly reduced larvae body length by 6%, inhibited the acetylcholinesterase activity by 40%, and upregulated gfap, α1-tubulin, zfrho and zfblue gene expression significantly...
February 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28169032/microplastics-in-freshwater-and-terrestrial-environments-evaluating-the-current-understanding-to-identify-the-knowledge-gaps-and-future-research-priorities
#2
REVIEW
Alice A Horton, Alexander Walton, David J Spurgeon, Elma Lahive, Claus Svendsen
Plastic debris is an environmentally persistent and complex contaminant of increasing concern. Understanding the sources, abundance and composition of microplastics present in the environment is a huge challenge due to the fact that hundreds of millions of tonnes of plastic material is manufactured for societal use annually, some of which is released to the environment. The majority of microplastics research to date has focussed on the marine environment. Although freshwater and terrestrial environments are recognised as origins and transport pathways of plastics to the oceans, there is still a comparative lack of knowledge about these environmental compartments...
February 3, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28168560/larvicidal-activity-of-blumea-eriantha-essential-oil-and-its-components-against-six-mosquito-species-including-zika-virus-vectors-the-promising-potential-of-4e-6z-allo-ocimene-carvotanacetone-and-dodecyl-acetate
#3
Giovanni Benelli, Marimuthu Govindarajan, Mohan Rajeswary, Sengamalai Senthilmurugan, Periasamy Vijayan, Naiyf S Alharbi, Shine Kadaikunnan, Jamal M Khaled
The effective and environmentally sustainable control of mosquitoes is a challenge of essential importance. This is due to the fact that some invasive mosquitoes, with special reference to the Aedes genus, are particularly difficult to control, due to their high ecological plasticity. Moreover, the indiscriminate overuse of synthetic insecticides resulted in undesirable effects on human health and non-target organisms, as well as resistance development in targeted vectors. Here, the leaf essential oil (EO) extracted from a scarcely studied plant of ethno-medicinal interest, Blumea eriantha (Asteraceae), was tested on the larvae of six mosquitoes, including Zika virus vectors...
February 6, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28168008/protective-effect-of-antioxidants-on-neuronal-dysfunction-and-plasticity-in-huntington-s-disease
#4
REVIEW
Thirunavukkarasu Velusamy, Archana S Panneerselvam, Meera Purushottam, Muthuswamy Anusuyadevi, Pramod Kumar Pal, Sanjeev Jain, Musthafa Mohamed Essa, Gilles J Guillemin, Mahesh Kandasamy
Huntington's disease (HD) is characterised by movement disorders, cognitive impairments, and psychiatric problems. The abnormal generation of reactive oxygen species and the resulting oxidative stress-induced mitochondrial damage in neurons upon CAG mutations in the HTT gene have been hypothesized as the contributing factors of neurodegeneration in HD. The potential use of antioxidants against free radical toxicity has been an emerging field in the management of ageing and many neurodegenerative disorders. Neural stem cells derived adult neurogenesis represents the regenerative capacity of the adult brain...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28167133/nmda-receptor-adjusted-co-administration-of-ecstasy-and-cannabinoid-receptor-1-agonist-in-the-amygdala-via-stimulation-of-bdnf-trk-b-creb-pathway-in-adult-male-rats
#5
Ghorbangol Ashabi, Mitra-Sadat Sadat-Shirazi, Solmaz Khalifeh, Laleh Elhampour, Mohammad-Reza Zarrindast
Consumption of cannabinoid receptor-1 (CB-1) agonist such as cannabis is widely taken in 3,4- methylenedioxymethamphetamine (MDMA) or ecstasy users; it has been hypothesized that co-consumption of CB-1 agonist might protect neurons against MDMA toxicity. N-methyl-D-aspartate (NMDA) receptors regulate neuronal plasticity and firing rate in the brain through Tyrosine-kinase B (Trk-B) activation. The molecular and electrophysiological association among NMDA and MDMA/Arachidonylcyclopropylamide (ACPA, a selective CB-1 receptor agonist) co-consumption was not well-known...
February 3, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28166271/transcriptional-deregulation-of-genetic-biomarkers-in-chironomus-riparius-larvae-exposed-to-ecologically-relevant-concentrations-of-di-2-ethylhexyl-phthalate-dehp
#6
Óscar Herrero, Gloria Morcillo, Rosario Planelló
Di(2-ethylhexyl) phthalate (DEHP) is a ubiquitous environmental pollutant used worldwide as a plasticizer and solvent in many formulations. Based on available toxicological data, it has been classified as toxic for reproduction and as an endocrine disruptor. Despite this, ecotoxicological studies in aquatic wildlife organisms are still scarce. In the present work, the toxic molecular alterations caused by DEHP in aquatic larvae of the midge Chironomus riparius have been studied, by analyzing the transcriptional activity of genes related to some vital cellular pathways, such as the ribosomal machinery (rpL4, rpL13), the cell stress response (hsc70, hsp70, hsp40, hsp27), the ecdysone hormone pathway (EcR), the energy metabolism (GAPDH), and detoxication processes (CYP4G)...
2017: PloS One
https://www.readbyqxmd.com/read/28163246/triphenyl-phosphate-enhances-adipogenic-differentiation-glucose-uptake-and-lipolysis-via-endocrine-and-noradrenergic-mechanisms
#7
German Cano-Sancho, Anna Smith, Michele A La Merrill
The use of triphenyl phosphate (TPhP) as a flame retardant or plasticizer has increased during the last decade, resulting in widespread human exposure without commensurate toxicity assessment. The main objectives of this study were to assess the in vitro effect of TPhP and its metabolite diphenyl phosphate (DPhP) on the adipogenic differentiation of 3T3-L1 cells, as well as glucose uptake and lipolysis in differentiated 3T3-L1 adipocytes. TPhP increased pre-adipocyte proliferation and subsequent adipogenic differentiation of 3T3-L1 cells, coinciding with increased transcription in the CEBP and PPARG pathway...
February 3, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28162048/bioconversion-of-fish-solid-waste-into-phb-using-bacillus-subtilis-based-submerged-fermentation-process
#8
S Mohapatra, B Sarkar, D P Samantaray, A Daware, S Maity, S Pattnaik, S Bhattacharjee
Currently, one of the major problem affecting the world is solid waste management predominantly petroleum based plastic and fish solid waste (FSW). However, it is very difficult to reduce the consumption of plastic as well as fish products, but it is promising to convert FSW to biopolymer to reduce eco-pollution. On account of that, the bioconversion of FSW extract to polyhydroxybutyrate (PHB) was under taken by using B. subtilis (KP172548). Under optimized condition 1.62 g/L of PHB have been produced by the bacterium...
February 6, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28147268/autonomous-camkii-activity-as-a-drug-target-for-histological-and-functional-neuroprotection-after-resuscitation-from-cardiac-arrest
#9
Guiying Deng, James E Orfila, Robert M Dietz, Myriam Moreno-Garcia, Krista M Rodgers, Steve J Coultrap, Nidia Quillinan, Richard J Traystman, K Ulrich Bayer, Paco S Herson
The Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is a major mediator of physiological glutamate signaling, but its role in pathological glutamate signaling (excitotoxicity) remains less clear, with indications for both neuro-toxic and neuro-protective functions. Here, the role of CaMKII in ischemic injury is assessed utilizing our mouse model of cardiac arrest and cardiopulmonary resuscitation (CA/CPR). CaMKII inhibition (with tatCN21 or tatCN19o) at clinically relevant time points (30 min after resuscitation) greatly reduces neuronal injury...
January 31, 2017: Cell Reports
https://www.readbyqxmd.com/read/28135260/water-based-and-biocompatible-2d-crystal-inks-for-all-inkjet-printed-heterostructures
#10
Daryl McManus, Sandra Vranic, Freddie Withers, Veronica Sanchez-Romaguera, Massimo Macucci, Huafeng Yang, Roberto Sorrentino, Khaled Parvez, Seok-Kyun Son, Giuseppe Iannaccone, Kostas Kostarelos, Gianluca Fiori, Cinzia Casiraghi
Exploiting the properties of two-dimensional crystals requires a mass production method able to produce heterostructures of arbitrary complexity on any substrate. Solution processing of graphene allows simple and low-cost techniques such as inkjet printing to be used for device fabrication. However, the available printable formulations are still far from ideal as they are either based on toxic solvents, have low concentration, or require time-consuming and expensive processing. In addition, none is suitable for thin-film heterostructure fabrication due to the re-mixing of different two-dimensional crystals leading to uncontrolled interfaces and poor device performance...
January 30, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28117406/insights-into-the-planktothrix-genus-genomic-and-metabolic-comparison-of-benthic-and-planktic-strains
#11
Claire Pancrace, Marie-Anne Barny, Reiko Ueoka, Alexandra Calteau, Thibault Scalvenzi, Jacques Pédron, Valérie Barbe, Joern Piel, Jean-François Humbert, Muriel Gugger
Planktothrix is a dominant cyanobacterial genus forming toxic blooms in temperate freshwater ecosystems. We sequenced the genome of planktic and non planktic Planktothrix strains to better represent this genus diversity and life style at the genomic level. Benthic and biphasic strains are rooting the Planktothrix phylogenetic tree and widely expand the pangenome of this genus. We further investigated in silico the genetic potential dedicated to gas vesicles production, nitrogen fixation as well as natural product synthesis and conducted complementary experimental tests by cell culture, microscopy and mass spectrometry...
January 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28115068/the-role-of-oxidative-stress-in-dna-damage-in-pancreatic-%C3%AE-cells-induced-by-di-2-ethylhexyl-phthalate
#12
Yan She, Liping Jiang, Liangliang Zheng, Heming Zuo, Min Chen, Xiance Sun, Qiujuan Li, Chengyan Geng, Guang Yang, Lijie Jiang, Xiaofang Liu
Di(2-ethyhexyl) phthalate (DEHP) is commonly used as a plasticizer, which loosely binds to plastic materials and easily leaches out of these products and enters into the environment. Exposure to DEHP can impair pancreatic beta cells (INS-1 cells)function, which is associated with Insulin Resistance (IR) and type 2 diabetes. However, the mechanism of how DEHP leads to Insulin Resistance is unknown. Our results showed that the cell viability of INS-1 cells exposed to DEHP (0-1600 μM) were decreased in a concentration-dependent manner...
January 20, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28101725/sustained-release-delivery-system-of-a-slow-hydrogen-sulfide-donor-gyy-4137-for-potential-application-in-glaucoma
#13
A Patil, S Singh, C Opere, A Dash
Hydrogen sulfide (H2S) targets both underlying factors in glaucoma pathogenesis by reducing elevated intraocular pressure (IOP) and providing retinal neuroprotection, whereas the current clinical approaches targets only reducing IOP. Therefore, H2S could be a potential superior candidate for glaucoma pharmacotherapy. However, H2S could be toxic in a concentration greater than 200 μM and its donors are unstable in water. Therefore, this study investigated the preparation and characterization of a non-aqueous in situ gelling sustained-release delivery system for H2S donors...
January 18, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28099091/acute-toxicity-of-chlorpyrifos-to-embryo-and-larvae-of-banded-gourami-trichogaster-fasciata
#14
Kizar Ahmed Sumon, Sampa Saha, Paul J van den Brink, Edwin T H M Peeters, Roel H Bosma, Harunur Rashid
This study elucidated the acute toxicity of chlorpyrifos on the early life stages of banded gourami (Trichogaster fasciata). To determine the acute effects of chlorpyrifos on their survival and development, we exposedthe embryos and two-day-old larvae to six concentrations (0, 0.01, 0.10, 1.0, 10 and 100 µg L(-1)) of chlorpyrifos in plastic bowls. Log-logistic regression was used to calculate LC10 and LC50 values. Results showed that embryo mortality significantly increased with increasing chlorpyrifos concentrations...
February 2017: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://www.readbyqxmd.com/read/28081197/morphine-withdrawal-modifies-prion-protein-expression-in-rat-hippocampus
#15
Vincenzo Mattei, Stefano Martellucci, Francesca Santilli, Valeria Manganelli, Tina Garofalo, Niccolò Candelise, Alessandra Caruso, Maurizio Sorice, Sergio Scaccianoce, Roberta Misasi
The hippocampus is a vulnerable brain structure susceptible to damage during aging and chronic stress. Repeated exposure to opioids may alter the brain so that it functions normally when the drugs are present, thus, a prolonged withdrawal might lead to homeostatic changes headed for the restoration of the physiological state. Abuse of morphine may lead to Reacting Oxygen Species-induced neurodegeneration and apoptosis. It has been proposed that during morphine withdrawal, stress responses might be responsible, at least in part, for long-term changes of hippocampal plasticity...
2017: PloS One
https://www.readbyqxmd.com/read/28078883/flexible-multistate-data-storage-devices-fabricated-using-natural-lignin-at-room-temperature
#16
Youngjun Park, Jang-Sik Lee
The growing interests for bioinspired and sustainable electronics have induced research for biocompatible and biodegradable materials. However, conventional electronic devices have been restricted due to its non-biodegradable and sometimes harmful and toxic material, which even cause environmental issues. Here, we report resistive switching memory (ReRAM) device based on lignin, which is a biodegradable waste product of the paper industry. The active layer of the device can be easily formed using a simple solution process on a plastic substrate...
January 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28068542/cost-effective-surface-modification-for-galinstan%C3%A2-lyophobicity
#17
Shantanu Shrikant Kadlaskar, Jun Hyeon Yoo, Abhijeet, Jeong Bong Lee, Wonjae Choi
In this paper we investigate the feasibility of using a cost-effective fabrication method based on sandblasting, chemical etching and spray coating processes, to render common surfaces to be non-wettable by Galinstan®. Although Galinstan® is a non-toxic liquid metal alternative to mercury, the viscoelastic and extremely wetting characteristics of Galinstan® have been the major bottleneck limiting the wide applicability of the gallium-based liquid metal. This paper tries to accomplish non-wettability to Galinstan® by combining surface texture and chemistry with the unique property of Galinstan®, that is, its high surface tension and yield strength that prevent the penetration of the liquid metal into surface asperities...
April 15, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28057345/emission-inventory-and-provincial-distribution-of-short-chain-chlorinated-paraffins-in-china
#18
Boya Zhang, Bu Zhao, Chun Xu, Jianbo Zhang
Chlorinated paraffins (CPs) are used as flame retardants, plasticizers, and metalworking fluids, which have varying contents of toxic short-chain chlorinated paraffins (SCCPs). Based on the study of several relevant production and consumption sectors, this paper classifies the consumption of CPs among sectors and provides an emission inventory and the provincial emission distribution of SCCPs in China in 2010-2014 based on the consumption patterns and emission factors of each sector. The total emissions of SCCPs in China in 2014 were 3083...
January 2, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28053038/large-soluble-oligomers-of-amyloid-%C3%AE-protein-from-alzheimer-brain-are-far-less-neuroactive-than-the-smaller-oligomers-to-which-they-dissociate
#19
Ting Yang, Shaomin Li, Huixin Xu, Dominic M Walsh, Dennis J Selkoe
: Soluble oligomers of amyloid β-protein (oAβ) isolated from the brains of Alzheimer's disease (AD) patients have been shown experimentally (in the absence of amyloid plaques) to impair hippocampal synaptic plasticity, decrease synapses, induce tau hyperphosphorylation and neuritic dystrophy, activate microglial inflammation, and impair memory in normal adult rodents. Nevertheless, there has been controversy about what types of oligomers actually confer these AD-like phenotypes. Here, we show that the vast majority of soluble Aβ species obtained from brains of humans who died with confirmed AD elute at high molecular weight (HMW) on nondenaturing size-exclusion chromatography...
January 4, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28051105/evaluation-of-hdpe-and-ldpe-degradation-by-fungus-implemented-by-statistical-optimization
#20
Nupur Ojha, Neha Pradhan, Surjit Singh, Anil Barla, Anamika Shrivastava, Pradip Khatua, Vivek Rai, Sutapa Bose
Plastic in any form is a nuisance to the well-being of the environment. The 'pestilence' caused by it is mainly due to its non-degradable nature. With the industrial boom and the population explosion, the usage of plastic products has increased. A steady increase has been observed in the use of plastic products, and this has accelerated the pollution. Several attempts have been made to curb the problem at large by resorting to both chemical and biological methods. Chemical methods have only resulted in furthering the pollution by releasing toxic gases into the atmosphere; whereas; biological methods have been found to be eco-friendly however they are not cost effective...
January 4, 2017: Scientific Reports
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