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https://www.readbyqxmd.com/read/28746997/removal-of-bisphenol-a-by-electrochemical-carbon-nanotube-filter-influential-factors-and-degradation-pathway
#1
Ahmed Refaat Bakr, Md Saifur Rahaman
Bisphenol A is a chemical with hazardous health effects that is largely used in the manufacture of extensively used products including adhesives, plastics, powder paints, thermal paper and paper coatings, and epoxy resin, and is reported to exist in nature in an accumulative manner. In this study, both pristine and boron-doped multiwalled carbon nanotubes (MWNTs) were employed as filtration and electrochemical filtration materials, resulting in a significant removal of bisphenol A with identical performance for both MWNTs types...
July 17, 2017: Chemosphere
https://www.readbyqxmd.com/read/28745240/nf-%C3%AE%C2%BAb-a-friend-a-foe-or-a-bystander-in-the-neurodegenerative-cascade-and-pathogenesis-of-alzheimer-s-disease
#2
Othman Ghribi
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a ubiquitous transcription factor that was discovered nearly three decades ago. Since its discovery, this protein complex has been implicated in numerous physiological and pathophysiological processes such as inflammation, insulin resistance, synaptic plasticity and memory as well as pathological conditions including cancer, autoimmune diseases, diabetes, and neurodegenerative diseases such as Alzheimer's disease. This review literature is focused on the potential role NF-κB may play in the etipathogenesis of Alzheimer's disease...
July 25, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28743368/chemoreception-drives-plastic-consumption-in-a-hard-coral
#3
Austin S Allen, Alexander C Seymour, Daniel Rittschof
The drivers behind microplastic (up to 5mm in diameter) consumption by animals are uncertain and impacts on foundational species are poorly understood. We investigated consumption of weathered, unfouled, biofouled, pre-production and microbe-free National Institute of Standards plastic by a scleractinian coral that relies on chemosensory cues for feeding. Experiment one found that corals ingested many plastic types while mostly ignoring organic-free sand, suggesting that plastic contains phagostimulents. Experiment two found that corals ingested more plastic that wasn't covered in a microbial biofilm than plastics that were biofilmed...
July 22, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28735028/protein-only-antimicrobial-peptide-containing-recombinant-nanoparticles-with-inherent-built-in-antibacterial-activity
#4
Naroa Serna, Laura Sánchez-García, Alejandro Sánchez-Chardi, Ugutz Unzueta, Mónica Roldán, Ramón Mangues, Esther Vázquez, Antonio Villaverde
The emergence of bacterial antibiotic resistances is a serious concern in human and animal health. In this context, naturally occurring cationic antimicrobial peptides (AMPs) might play a main role in a next generation of drugs against bacterial infections. Taking an innovative approach to design self-organizing functional proteins, we have generated here protein-only nanoparticles with intrinsic AMP microbicide activity. Using a recombinant version of the GWH1 antimicrobial peptide as building block, these materials show a wide antibacterial activity spectrum in absence of detectable toxicity on mammalian cells...
July 19, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28732337/critical-review-of-soil-contamination-by-polybrominated-diphenyl-ethers-pbdes-and-novel-brominated-flame-retardants-nbfrs-concentrations-sources-and-congener-profiles
#5
REVIEW
Thomas J McGrath, Andrew S Ball, Bradley O Clarke
Polybrominated diphenyl ethers (PBDEs) have been used in a broad array of polymeric materials such as plastics, foams, resins and adhesives to inhibit the spread of fires since the 1970s. The widespread environmental contamination and well documented toxic effects of PBDEs have led to bans and voluntary withdrawals in many jurisdictions. Replacement novel brominated flame retardants (NBFRs) have, however, exhibited many of the same toxic characteristics as PBDEs and appear to share similar environmental fate...
July 18, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28728088/phthalate-and-non-phthalate-plasticizers-in-indoor-dust-from-childcare-facilities-salons-and-homes-across-the-usa
#6
Bikram Subedi, Kenneth D Sullivan, Birendra Dhungana
The quality of indoor environment has received considerable attention owing to the declining outdoor human activities and the associated public health issues. The prolonged exposure of children in childcare facilities or the occupational exposure of adults to indoor environmental triggers can be a culprit of the pathophysiology of several commonly observed idiopathic syndromes. In this study, concentrations of potentially toxic plasticizers (phthalates as well as non-phthalates) were investigated in 28 dust samples collected from three different indoor environments across the USA...
July 17, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28726228/microwave-irradiation-and-citric-acid-assisted-seed-germination-and-phytoextraction-of-nickel-ni-by-brassica-napus-l-morpho-physiological-and-biochemical-alterations-under-ni-stress
#7
Mujahid Farid, Shafaqat Ali, Muhammad Rizwan, Rashid Saeed, Hafiz Muhammad Tauqeer, Rasham Sallah-Ud-Din, Ahmed Azam, Nighat Raza
The complex bio-geochemistry of soil allows pollutant to persist for a longer period of time which further decreased the fertility and natural composition of land. Nickel, an inorganic pollutant, coming from a wide range of industrial and manufacturing units possesses serious threat to soil degradation and crop productivity around the world. The present study was carried to evaluate the combined role of microwave irradiation (MR) and citric acid (CA) on the phytoextraction potential of Brassica napus L. under Ni stress...
July 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28715401/extraction-of-organochlorine-pesticides-from-plastic-pellets-and-plastic-type-analysis
#8
Marilyne Pflieger, Petra Makorič, Manca Kovač Viršek, Špela Koren
Plastic resin pellets, categorized as microplastics (≤5 mm in diameter), are small granules that can be unintentionally released to the environment during manufacturing and transport. Because of their environmental persistence, they are widely distributed in the oceans and on beaches all over the world. They can act as a vector of potentially toxic organic compounds (e.g., polychlorinated biphenyls) and might consequently negatively affect marine organisms. Their possible impacts along the food chain are not yet well understood...
July 1, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28709981/relative-toxicity-for-indoor-semi-volatile-organic-compounds-based-on-neuronal-death
#9
Kevin Fournier, Emmanuel Baumont, Philippe Glorennec, Nathalie Bonvallot
BACKGROUND: Semi Volatile Organic Compounds (SVOCs) are contaminants commonly found in dwellings as a result of their use as plasticizers, flame retardants, or pesticides in building materials and consumer products. Many SVOCs are suspected of being neurotoxic, based on mammal experimentation (impairment of locomotor activity, spatial learning/memory or behavioral changes), raising the question of cumulative risk assessment. The aim of this work is to estimate the relative toxicity of such SVOCs, based on neuronal death...
July 11, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28698671/morphology-composition-and-mixing-state-of-primary-particles-from-combustion-sources-crop-residue-wood-and-solid-waste
#10
Lei Liu, Shaofei Kong, Yinxiao Zhang, Yuanyuan Wang, Liang Xu, Qin Yan, A P Lingaswamy, Zongbo Shi, Senlin Lv, Hongya Niu, Longyi Shao, Min Hu, Daizhou Zhang, Jianmin Chen, Xiaoye Zhang, Weijun Li
Morphology, composition, and mixing state of individual particles emitted from crop residue, wood, and solid waste combustion in a residential stove were analyzed using transmission electron microscopy (TEM). Our study showed that particles from crop residue and apple wood combustion were mainly organic matter (OM) in smoldering phase, whereas soot-OM internally mixed with K in flaming phase. Wild grass combustion in flaming phase released some Cl-rich-OM/soot particles and cardboard combustion released OM and S-rich particles...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28697425/are-the-tio2-nps-a-trojan-horse-for-personal-care-products-pcps-in-the-clam-ruditapes-philippinarum
#11
M Sendra, M G Pintado-Herrera, G V Aguirre-Martínez, I Moreno-Garrido, L M Martin-Díaz, P A Lara-Martín, Blasco J
In recent years, increasing quantities of personal care products (PCPs) are being released into the environment. However, data about bioaccumulation and toxicity are scarce; and extraction and analytical approaches are not well developed. In this work, the marine clam Ruditapes philippinarum, selected as model organism, has been employed to investigate bioaccumulation, antioxidant enzyme activities and DNA damage due to exposure to TiO2 nanoparticles and bulk TiO2 (inorganic compounds that are frequent components of PCPs, plastics, paints and coatings, foods and disinfectant water treatments)...
July 3, 2017: Chemosphere
https://www.readbyqxmd.com/read/28694178/medicinal-plants-used-in-the-treatment-of-tuberculosis-ethnobotanical-and-ethnopharmacological-approaches
#12
REVIEW
Javad Sharifi-Rad, Bahare Salehi, Zorica Z Stojanović-Radić, Patrick Valere Tsouh Fokou, Marzieh Sharifi-Rad, Gail B Mahady, Majid Sharifi-Rad, Mohammad-Reza Masjedi, Temitope O Lawal, Seyed Abdulmajid Ayatollahi, Javid Masjedi, Razieh Sharifi-Rad, William N Setzer, Mehdi Sharifi-Rad, Farzad Kobarfard, Atta-Ur Rahman, Muhammad Iqbal Choudhary, Athar Ata, Marcello Iriti
Tuberculosis is a highly infectious disease declared a global health emergency by the World Health Organization, with approximately one third of the world's population being latently infected with Mycobacterium tuberculosis. Tuberculosis treatment consists in an intensive phase and a continuation phase. Unfortunately, the appearance of multi drug-resistant tuberculosis, mainly due to low adherence to prescribed therapies or inefficient healthcare structures, requires at least 20months of treatment with second-line, more toxic and less efficient drugs, i...
July 8, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28689280/analysis-of-toxicity-effects-of-di-2-ethylhexyl-phthalate-exposure-on-human-bronchial-epithelial-16hbe-cells
#13
Yue Ma, Yinsheng Guo, Shuang Wu, Ziquan Lv, Qian Zhang, Xing Xie, Yuebin Ke
Recent studies have indicated that Di-(2-ethylhexyl) phthalate (DEHP), the most commonly used plasticizer in daily-life products, could be dispersed in indoor air and induce human exposure via inhalation. DEHP has been reported to have effects on the respiratory system in both animal and human researches. The toxicity effects of DEHP exposure on cell proliferation, cell cycle progression, apoptosis, global DNA methylation and the expression levels of DNA methyltransferases (DNMTs) were investigated in this study, using human epithelial cell line 16HBE as an in vitro model...
July 8, 2017: Cytotechnology
https://www.readbyqxmd.com/read/28689058/protective-effect-of-crocin-on-bpa-induced-liver-toxicity-in-rats-through-inhibition-of-oxidative-stress-and-downregulation-of-mapk-and-mapkap-signaling-pathway-and-mirna-122-expression
#14
Faezeh Vahdati Hassani, Soghra Mehri, Khalil Abnous, Ruth Birner-Gruenberger, Hossein Hosseinzadeh
Bisphenol A (BPA) is an artificial environmental endocrine disrupting chemical and commonly used as a monomer of polycarbonate plastics and epoxy resins. The aim of the present study is to investigate the hepatoprotective effects of crocin, a constituent of saffron, against BPA-induced liver toxicity. We showed that treatment of male Wistar rats with 0.5 mg/kg BPA for 30 days increased the level of 8-isoprostane, decreased the level of reduced glutathione, elevated serum levels of aspartate aminotransferase, lactate dehydrogenase, triglyceride, and glucose, and induced periportal inflammation...
July 6, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28688845/assessing-the-phytoremediation-potential-of-crop-and-grass-plants-for-atrazine-spiked-soils
#15
Virtudes Sánchez, Francisco Javier López-Bellido, Pablo Cañizares, Luis Rodríguez
Pollution of soil and groundwater by atrazine has become an increasing environmental concern in the last decade. A phytoremediation test using plastic pots was conducted in order to assess the ability of several crops and grasses to remove atrazine from a soil of low permeability spiked with this herbicide. Four plant species were assessed for their ability to degrade or accumulate atrazine from soils: two grasses, i.e., ryegrass (Lolium perenne) and tall fescue (Festuca arundinacea), and two crops, i.e., barley (Hordeum vulgare) and maize (Zea mays)...
July 4, 2017: Chemosphere
https://www.readbyqxmd.com/read/28688339/brain-derived-neurotrophic-factor-signaling-plays-a-role-in-resilience-to-stress-promoted-by-isoquinoline-in-defeated-mice
#16
Ana Paula Pesarico, Suzan G Rosa, Franciele Martini, Tales A Goulart, Gilson Zeni, Cristina Wayne Nogueira
Certain stressful life events have been associated with the onset of depression. This study aims to investigate if 7-fluoro-1,3-diphenylisoquinoline-1-amine (FDPI) is effective against social avoidance induced by social defeat stress model in mice. Furthermore, it was investigated the effects of FDPI in the mouse prefrontal cortical plasticity-related proteins and some parameters of toxicity. Adult Swiss mice were subjected to social defeat stress for 10 days. Two protocols with FDPI were carried out: 1- FDPI (25 mg/kg, intragastric) was administered to mice 24 h after the last social defeat stress episode; 2- FDPI (1-25 mg/kg, intragastric) was administered to mice once a day for 10 days concomitant with the social defeat stress...
June 30, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28688303/effect-of-styrene-exposure-on-plasma-parameters-molecular-mechanisms-and-gene-expression-in-rat-model-islet-cells
#17
Kamal Niaz, Fatima Ismail Hassan, Faheem Mabqool, Fazlullah Khan, Saeideh Momtaz, Maryam Baeeri, Mona Navaei-Nigjeh, Mahban Rahimifard, Mohammad Abdollahi
Styrene is an aromatic hydrocarbon compound present in the environment and have primary exposure through plastic industry. The current study was designed to evaluate styrene-induced toxicity parameters in rat plasma fasting blood glucose (FBG) level, oral glucose tolerance, insulin secretion, oxidative stress, and inflammatory cytokines in cellular and molecular levels. Styrene was dissolved in corn oil and administered at different doses (250, 500, 1000, 1500, 2000mg/kg/day and control) to each rat, for 42days...
June 23, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28687316/levodopa-l-dopa-attenuates-endoplasmic-reticulum-stress-response-and-cell-death-signaling-through-drd2-in-sh-sy5y-neuronal-cells-under-%C3%AE-synuclein-induced-toxicity
#18
Juhyun Song, Byeong C Kim, Dai-Trang T Nguyen, Manikandan Samidurai, Seong-Min Choi
Parkinson's disease (PD) is characterized by the formation of Lewy bodies (LBs) in dopaminergic neurons. α-Synuclein (α-syn), a major protein component of LBs, is known to regulate synaptic plasticity, with a crucial role in memory and motor function in the central nervous system. Levodopa (L-3,4-dihydroxyphenylalanine; also known as L-DOPA) is considered the most effective medication for controlling the symptoms of PD. However, it is unclear whether L-DOPA improves the neuropathology of PD. In the present study, we investigated the effect of L-DOPA on SH-SY5Y neuronal cells under α-syn-induced toxicity...
July 4, 2017: Neuroscience
https://www.readbyqxmd.com/read/28683776/trpa1-channels-promote-astrocytic-ca-2-hyperactivity-and-synaptic-dysfunction-mediated-by-oligomeric-forms-of-amyloid-%C3%AE-peptide
#19
Anthony Bosson, Adrien Paumier, Sylvie Boisseau, Muriel Jacquier-Sarlin, Alain Buisson, Mireille Albrieux
BACKGROUND: Excessive synaptic loss is thought to be one of the earliest events in Alzheimer's disease (AD). However, the key mechanisms that maintain plasticity of synapses during adulthood or initiate synapse dysfunction in AD remain unknown. Recent studies suggest that astrocytes contribute to functional changes observed during synaptic plasticity and play a major role in synaptic dysfunction but astrocytes behavior and involvement in early phases of AD remained largely undefined. METHODS: We measure astrocytic calcium activity in mouse CA1 hippocampus stratum radiatum in both the global astrocytic population and at a single cell level, focusing in the highly compartmentalized astrocytic arbor...
July 6, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/28678785/dependency-of-a-therapy-resistant-state-of-cancer-cells-on-a-lipid-peroxidase-pathway
#20
Vasanthi S Viswanathan, Matthew J Ryan, Harshil D Dhruv, Shubhroz Gill, Ossia M Eichhoff, Brinton Seashore-Ludlow, Samuel D Kaffenberger, John K Eaton, Kenichi Shimada, Andrew J Aguirre, Srinivas R Viswanathan, Shrikanta Chattopadhyay, Pablo Tamayo, Wan Seok Yang, Matthew G Rees, Sixun Chen, Zarko V Boskovic, Sarah Javaid, Cherrie Huang, Xiaoyun Wu, Yuen-Yi Tseng, Elisabeth M Roider, Dong Gao, James M Cleary, Brian M Wolpin, Jill P Mesirov, Daniel A Haber, Jeffrey A Engelman, Jesse S Boehm, Joanne D Kotz, Cindy S Hon, Yu Chen, William C Hahn, Mitchell P Levesque, John G Doench, Michael E Berens, Alykhan F Shamji, Paul A Clemons, Brent R Stockwell, Stuart L Schreiber
Plasticity of the cell state has been proposed to drive resistance to multiple classes of cancer therapies, thereby limiting their effectiveness. A high-mesenchymal cell state observed in human tumours and cancer cell lines has been associated with resistance to multiple treatment modalities across diverse cancer lineages, but the mechanistic underpinning for this state has remained incompletely understood. Here we molecularly characterize this therapy-resistant high-mesenchymal cell state in human cancer cell lines and organoids and show that it depends on a druggable lipid-peroxidase pathway that protects against ferroptosis, a non-apoptotic form of cell death induced by the build-up of toxic lipid peroxides...
July 27, 2017: Nature
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