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https://www.readbyqxmd.com/read/29471517/the-role-of-the-ground-glass-opacity-ratio-in-resected-lung-adenocarcinoma
#1
Tsai-Wang Huang, Kuan-Hsun Lin, Hsu-Kai Huang, Yi-I Chen, Kai-Hsiung Ko, Cheng-Kuang Chang, Hsian-He Hsu, Hung Chang, Shih-Chun Lee
OBJECTIVES: The goal of this study was to investigate the role of the ground-glass opacity (GGO) ratio in lung adenocarcinoma in predicting surgical outcomes. METHODS: Patients who underwent surgical resection for pulmonary adenocarcinoma between January 2004 and December 2013 were reviewed. The clinical data, imaging characteristics of nodules, surgical approaches and outcomes were analysed with a mean follow-up of 87 months. RESULTS: Of 789 enrolled patients, 267 cases were categorized as having a GGO ratio ≥0...
February 19, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29471273/effect-of-simultaneously-induced-environmental-stimuli-on-electrical-signalling-and-gas-exchange-in-maize-plants
#2
Jasmin Vuralhan-Eckert, Silke Lautner, Jörg Fromm
Electrical signalling in response to environmental stimuli is a well-known phenomenon in higher plants. For example, in maize, different stimuli, such as wounding or re-irrigation after drought, incite characteristic electrical signals which have quite particular effects on gas exchange. What is less well understood is how plants (specifically maize) respond when two different environmental stimuli are applied simultaneously. To explore this, a three-stage experiment was designed. In the first stage, drought conditions were simulated by decreasing the soil water content to 30-40 % of field capacity...
February 10, 2018: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29471235/competition-between-heavy-metal-ions-for-binding-sites-in-lichens-implications-for-biomonitoring-studies
#3
Luca Paoli, Andrea Vannini, Fabrizio Monaci, Stefano Loppi
The competitive behavior of divalent heavy metals (Cd, Cr, Pb, Zn) during cation uptake was investigated in the foliose lichen Xanthoria parietina. Lichen thalli were incubated with solutions containing 10 and 100 μM of CdCl2, CuCl2, and ZnCl2 as well as 5 and 50 μM of Pb(NO3 )2 , tested individually and in combination (Cd2+ +Cu2+ +Pb2+ +Zn2+ ). The analysis of molar concentrations suggests that a competition between cations for binding sites in X. parietina does exist. The decrease in net uptake between single and mixed solutions ranged between 14 and 29% at the lowest concentration and between 38 and 68% at the highest concentration...
February 19, 2018: Chemosphere
https://www.readbyqxmd.com/read/29471218/albumin-covered-lipid-nanocapsules-exhibit-enhanced-uptake-performance-by-breast-tumor-cells
#4
F Galisteo-González, J A Molina-Bolívar, S A Navarro, H Boulaiz, A Aguilera-Garrido, A Ramírez, J A Marchal
Liquid lipid nanocapsules (LLN) represent a promising new generation of drug-delivery systems. They can carry hydrophobic drugs in their oily core, but the composition and structure of the surrounding protective shell determine their capacity to survive in the circulatory system and to achieve their goal: penetrate tumor cells. Here, we present a study of LLN covered by the protein human serum albumin (HSA) and loaded with curcumin as a hydrophobic model drug. A cross-linking procedure was performed to further strengthen the protective protein layer...
February 13, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29471214/joint-associations-of-%C3%AE-amyloidosis-and-cortical-thickness-with-cognition
#5
David S Knopman, Emily S Lundt, Terry M Therneau, Prashanthi Vemuri, Val J Lowe, Kejal Kantarci, Jeffrey L Gunter, Matthew L Senjem, Michelle M Mielke, Mary M Machulda, Rosebud O Roberts, Bradley F Boeve, David T Jones, Ronald C Petersen, Clifford R Jack
In 1164 cognitively unimpaired persons, aged 50-95 years, from the population-based Mayo Clinic Study of Aging, we examined the relationships of baseline cognition and cognitive changes across the full range of cortical thickness of an Alzheimer signature region of interest and global β-amyloid levels measured by Pittsburgh compound B positron emission tomography (PIB PET) standardized uptake value ratio (SUVR). In machine-learning models accounting for both biomarkers simultaneously, worsening biomarker values were additive and associated with lower baseline global cognition and greater subsequent decline in global cognition...
February 2, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29471211/exogenous-nanosilica-improves-germination-and-growth-of-cucumber-by-maintaining-k-na-ratio-under-elevated-na-stress
#6
Abdullah Alsaeedi, Hassan El-Ramady, Tarek Alshaal, Mohamed El-Garawani, Nevien Elhawat, Awadh Al-Otaibi
The current work was aimed to elucidate the role of engineered nanosilica (SiNPs) particles to mitigate the damaging impacts of Na+ -derived salinity on cucumber (Cucumis sativus) Beit Alpha variety by conducting in vitro experiments applying various Na+ concentrations i.e. 0, 1000, 2000, 3000, 4000 and 5000 mg L-1 . By treating seeds and seedlings, respectively, of cucumber with SiNPs (0, 100, 200 and 300 ppm) and subsequent determination some germination and vegetative parameters as well as chemical analysis of seedlings, we verified that SiNPs succeeded to alleviate the detrimental effects of high Na+ salinity by increasing germination parameters and vegetative growth of cucumber seedlings...
February 9, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29471169/pegylated-dendritic-polyglycerol-conjugate-targeting-ncam-expressing-neuroblastoma-limitations-and-challenges
#7
Laura Isabel Vossen, Ela Markovsky, Anat Eldar-Boock, Harald Rune Tschiche, Stefanie Wedepohl, Evgeny Pisarevsky, Ronit Satchi-Fainaro, Marcelo Calderón
Neural cell adhesion molecule (NCAM) is found to be a stem-cell marker in several tumor types and its overexpression is known to correlate with increased metastatic capacity. To combine extravasation- and ligand-dependent targeting to NCAM overexpressing-cells in the tumor microenvironment, we developed a PEGylated NCAM-targeted dendritic polyglycerol (PG) conjugate. Here, we describe the synthesis, physico-chemical characterization and biological evaluation of a PG conjugate bearing the mitotic inhibitor paclitaxel (PTX) and an NCAM-targeting peptide (NTP)...
February 19, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29471093/chemical-cross-linked-polyvinyl-alcohol-cellulose-nanocrystal-composite-films-with-high-structural-stability-by-spraying-fenton-reagent-as-initiator
#8
Meili Song, Houyong Yu, Jiping Gu, Shounuan Ye, Yuwei Zhou
Cross-linked polyvinyl alcohol (PVA) composite films with high structural stability were prepared by free radical copolymerization between cellulose nanocrystal (CNC) and maleic anhydride (MAH) modified PVA through spraying Fenton free radical as initiator. The influence of chemical cross-linked and physical network structure on mechanical, thermal and water absorption properties of the composite films were investigated. Compared to PVA and PVA/CNC composite film, significant improvements in the mechanical, thermal and water uptake properties of the cross-linked composite film were found...
February 19, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29471040/biodistribution-activation-and-retention-of-proinsulin-transferrin-fusion-protein-in-the-liver-mechanism-of-liver-targeting-as-an-insulin-prodrug
#9
Yuqian Liu, Hsuan-Yao Wang, Li Zhou, Yang Su, Wei-Chiang Shen
A recombinant proinsulin-transferrin fusion protein (ProINS-Tf) has been previously reported to be a novel long-lasting INS analog, acting specifically on the inhibition of hepatic glucose output. In this study, we investigated the biodistribution, activation and tissue retention of ProINS-Tf to elucidate its liver targeted anti-diabetic mechanism. The biodistribution study revealed that ProINS-Tf exhibited liver specific accumulation after a single intravenous injection, whereas transferrin (Tf) or insulin (INS) showed relatively even distribution among different organs...
February 19, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29470999/mast-cells-regulate-cd4-t-cell-differentiation-in-absence-of-antigen-presentation
#10
Hector Rodriguez Cetina Biefer, Timm Heinbokel, Hirofumi Uehara, Virginia Camacho, Koichiro Minami, Yeqi Nian, Suresh Koduru, Rachid El Fatimy, Ionita Ghiran, Alexander J Trachtenberg, Miguel A de la Fuente, Haruhito Azuma, Omid Akbari, Stefan G Tullius, Anju Vasudevan, Abdallah Elkhal
BACKGROUND: Given their unique capacity for antigen uptake, processing, and presentation, antigen presenting cells (APCs) are critical for initiating and regulating innate and adaptive immune responses. We have previously shown the role of nicotinamide adenine dinucleotide (NAD+ ) in T cell differentiation independently of the cytokine milieu, while the precise mechanisms remained unknown. OBJECTIVE: The objective of this study is to further dissect the mechanism of actions of NAD+ , and to determine the impact of APCs on NAD+ -mediated T cell activation...
February 19, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29470983/development-of-a-functional-thyroid-model-based-on-an-organoid-culture-system
#11
Yoshiyuki Saito, Nobuyuki Onishi, Hiroshi Takami, Ryo Seishima, Hiroyoshi Inoue, Yuki Hirata, Kaori Kameyama, Kenji Tsuchihashi, Eiji Sugihara, Shinya Uchino, Koichi Ito, Hirofumi Kawakubo, Hiroya Takeuchi, Yuko Kitagawa, Hideyuki Saya, Osamu Nagano
The low turnover rate of thyroid follicular cells and the lack of a long-term thyroid cell culture system have hampered studies of thyroid carcinogenesis. We have now established a thyroid organoid culture system that supports thyroid cell proliferation in vitro. The established mouse thyroid organoids performed thyroid functions including thyroglobulin synthesis, iodide uptake, and the production and release of thyroid hormone. Furthermore, transplantation of the organoids into recipient mice resulted in the formation of normal thyroid-like tissue capable of iodide uptake and thyroglobulin production in vivo...
February 19, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29470827/in-vitro-characterization-and-evaluation-of-the-cytotoxicity-effects-of-nisin-and-nisin-loaded-pla-peg-pla-nanoparticles-on-gastrointestinal-ags-and-kyse-30-hepatic-hepg2-and-blood-k562-cancer-cell-lines
#12
Fariba Goudarzi, Asadollah Asadi, Maryam Afsharpour, Robab Hassanvand Jamadi
The aim of this study was an in vitro evaluation and comparison of the cytotoxic effects of free nisin and nisin-loaded PLA-PEG-PLA nanoparticles on gastrointestinal (AGS and KYSE-30), hepatic (HepG2), and blood (K562) cancer cell lines. To create this novel anti-cancer drug delivery system, the nanoparticles were synthesized and then loaded with nisin. Subsequently, their biocompatibility, ability to enter cells, and physicochemical properties, including formation, size, and shape, were studied using hemolysis, fluorescein isothiocyanate (FITC), Fourier transform infrared (FTIR) spectroscopy, dynamic light scattering (DLS), and scanning electron microscopy (SEM), respectively...
February 22, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29470802/male-undergraduates-hpv-vaccination-behavior-implications-for-achieving-hpv-associated-cancer-equity
#13
Hee Yun Lee, Katherine Lust, Suzanne Vang, Jay Desai
Despite the availability of the human papillomavirus (HPV) vaccine for males, uptake of the vaccine has been low, particularly among young adult males. This study aimed to investigate the levels of HPV vaccination and predictors of HPV vaccine completion in college men ages 18-26. We analyzed data from the 2015 College Student Health Survey, which was administered at 17 post-secondary institutions in Midwest areas. We included only responses from male participants who were ages 18-26 years old, resulting in a sample size of 2516...
February 22, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/29470774/multi-indication-and-combination-pricing-and-reimbursement-of-pharmaceuticals-opportunities-for-improved-health-care-through-faster-uptake-of-new-innovations
#14
Ulf Persson, J M Norlin
Many pharmaceuticals are effective in multiple indications and the degree of effectiveness may differ. A product-based pricing and reimbursement system with a single price per product is insufficient to reflect the variable values between different indications. The objective of this article is to present examples of actual pricing and reimbursement decisions using current value-based pricing in Sweden and to discuss their implications and possible solutions. The value of several cancer drugs was estimated for various indications based on a willingness-to-pay threshold of 1 million SEK (EUR 104,000) per QALY gained...
February 22, 2018: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/29470615/pre-dosing-with-lilotomab-prior-to-therapy-with-177-lu-lilotomab-satetraxetan-significantly-increases-the-ratio-of-tumor-to-red-marrow-absorbed-dose-in-non-hodgkin-lymphoma-patients
#15
Caroline Stokke, Johan Blakkisrud, Ayca Løndalen, Jostein Dahle, Anne C T Martinsen, Harald Holte, Arne Kolstad
PURPOSE: 177 Lu-lilotomab satetraxetan is a novel anti-CD37 antibody radionuclide conjugate for the treatment of non-Hodgkin lymphoma (NHL). Four arms with different combinations of pre-dosing and pre-treatment have been investigated in a first-in-human phase 1/2a study for relapsed CD37+ indolent NHL. The aim of this work was to determine the tumor and normal tissue absorbed doses for all four arms, and investigate possible variations in the ratios of tumor to organs-at-risk absorbed doses...
February 22, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29470434/pharmacokinetics-and-scintigraphic-imaging-of-the-hypoxia-imaging-agent-123-i-iaza-in-healthy-adults-following-exercise-based-cardiac-stress-%C3%A2
#16
Daria Stypinski, Stephen A McQuarrie, Alexander J B McEwan, Leonard I Wiebe
The objective of this work is to evaluate the potential effect of cardiac stress exercise on the accumulation of [123 I]IAZA, a radiopharmaceutical used to image focal tissue hypoxia, in otherwise normal myocardium in healthy volunteers, and to determine the impact of exercise on [123 I]IAZA pharmacokinetics. The underlying goal is to establish a rational basis and a baseline for studies of focal myocardial hypoxia in cardiac patients using [123 I]IAZA. Three healthy male volunteers ran the 'Bruce' treadmill protocol, a clinically-accepted protocol designed to expose myocardial ischemia in patients...
February 22, 2018: Pharmaceutics
https://www.readbyqxmd.com/read/29470420/enhanced-antitumor-effects-of-epidermal-growth-factor-receptor-targetable-cetuximab-conjugated-polymeric-micelles-for-photodynamic-therapy
#17
Ming-Hsiang Chang, Chin-Ling Pai, Ying-Chen Chen, Hsiu-Ping Yu, Chia-Yen Hsu, Ping-Shan Lai
Nanocarrier-based delivery systems are promising strategies for enhanced therapeutic efficacy and safety of toxic drugs. Photodynamic therapy (PDT)-a light-triggered chemical reaction that generates localized tissue damage for disease treatments-usually has side effects, and thus patients receiving photosensitizers should be kept away from direct light to avoid skin phototoxicity. In this study, a clinically therapeutic antibody cetuximab (C225) was conjugated to the surface of methoxy poly(ethylene glycol)- b -poly(lactide) (mPEG- b -PLA) micelles via thiol-maleimide coupling to allow tumor-targetable chlorin e6 (Ce6) delivery...
February 22, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29470144/the-effect-of-mono-and-diglycerides-on-the-digestion-and-aborption-of-lutein-in-lymph-fistula-rats
#18
Patrick Tso, Mustafa Vurma, Chih-Wei Ko, Dana M Lee, Stephen DeMichele
Breastmilk lutein is better absorbed by infants than lutein delivered in infant formula. Therefore, we wish to better understand the possible absorption differences of lutein in breast milk versus infant formula by determining its bioavailability after gastric administration and whether the intestinal absorption of lutein can be improved by using new delivery vehicles. STUDY ONE compared the intestinal uptake, and the lymphatic and portal transport of lutein in conscious lymph fistula rats. Four groups of lymph and portal vein cannulated rats (n = 8-10/group) were randomized to receive via the gastric tube increasing doses (10,20,40,or 80mg/kg) of 20% lutein in safflower oil (SO) suspension to assess whether there was a saturable level of lutein that can be absorbed and transported in lymph...
February 22, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29470122/a-qualitative-comparative-analysis-of-combined-state-health-policies-related-to-human-papillomavirus-vaccine-uptake-in-the-united-states
#19
Megan C Roberts, Taylor Murphy, Jennifer L Moss, Christopher W Wheldon, Wayne Psek
OBJECTIVES: To examine how combinations of state policies, rather than single policies, are related to uptake of human papillomavirus (HPV) vaccine. METHODS: Using publicly available records and the literature, we characterized policies for each US state and Washington, DC, in 2015 (n = 51), including (1) Medicaid expansion, (2) policies permitting HPV vaccination in pharmacies, (3) school-entry requirements, (4) classroom sex education mandates, and (5) parental education mandates...
February 22, 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29470118/the-inverse-equity-hypothesis-analyses-of-institutional-deliveries-in-286-national-surveys
#20
Cesar Gomes Victora, Gary Joseph, Inacio C M Silva, Fatima S Maia, J Patrick Vaughan, Fernando C Barros, Aluisio J D Barros
OBJECTIVES: To test the inverse equity hypothesis, which postulates that new health interventions are initially adopted by the wealthy and thus increase inequalities-as population coverage increases, only the poorest will lag behind all other groups. METHODS: We analyzed the proportion of births occurring in a health facility by wealth quintile in 286 surveys from 89 low- and middle-income countries (1993-2015) and developed an inequality pattern index. Positive values indicate that inequality is driven by early adoption by the wealthy (top inequality), whereas negative values signal bottom inequality...
February 22, 2018: American Journal of Public Health
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