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Imran Ali, Omar M L Alharbi, Zeid A Alothman, Abdulrahman Alwarthan
Enantio-selective molecular dynamics of (±)-o,p-DDT uptake and degradation in water-sediment system is described. Both uptake and degradation processes of (-)-o,p-DDT were slightly higher than (+)-o,p-DDT enantiomer. The optimized parameters for uptake were 7.0μgL(-1) concentration of o,p-DDT, 60min contact time, 5.0pH, 6.0gL(-1) amount of reverine sediment and 25°C temperature. The maximum degradation of both (-)- and (+)-o,p-DDT was obtained with 16 days, 0.4μgL(-1) concentration of o,p-DDT, pH 7 and 35°C temperature...
October 18, 2017: Environmental Research
Jeng-Yan Su, Chien-Hui Syu, Dar-Yuan Lee
Limited information exists on the effects of emerging contaminants gallium (Ga) and indium (In) on rice plant growth. This study investigated the effects on growth and uptake of Ga and In by rice plants grown in soils with different properties. Pot experiment was conducted and the rice seedlings were grown in two soils of different pH (Pc and Cf) spiked with various Ga and In concentrations. The results showed concentrations of Ga, In, and Al in soil pore water increased with Ga- or In-spiking in acidic Pc soils, significantly decreasing growth indices...
October 12, 2017: Journal of Hazardous Materials
Saeid Zarei, Mahmood Niad, Hossein Raanaei
In this study, we have attempted to extract cellulose from Cystoseria myricaas algae. Nanocellulose, Fe3O4 and Fe3O4-nanocellulose compounds are synthesized by acid hydrolysis and co-precipitation as well as sol-gel methods The synthesized compounds are characterized by x-ray diffraction, transmission electron microscopy, particle size distribution (PSD), scanning electron microscopy (SEM),energy dispersive x-ray spectroscopy, vibrating sample magnetometer and Fourier transform infrared spectroscopy. The Hg (II) uptake on Fe3O4-nanocellulose is investigated by 14 isotherm models, 12 kinetic models, adsorption activation energy as well as thermodynamic of adsorption...
October 12, 2017: Journal of Hazardous Materials
Elsa L Aguirre-Benítez, Mercedes G Porras, Leticia Parra, Jacquelina González-Ríos, Dafne F Garduño-Torres, Damaris Albores-García, Arturo Avendaño, Miguel A Ávila-Rodríguez, Angel I Melo, Ismael Jiménez-Estrada, Ma Eugenia Mendoza-Garrido, César Toriz, Daniel Diaz, Elizabeth Ibarra-Coronado, Karina Mendoza-Ángeles, Jesús Hernández-Falcón
Early adverse life-stress has been associated to behavioral disorders that can manifest as inappropriate or aggressive responses to social challenges. In this study, we analyzed the effects of artificial rearing on the open field and burial behavioral tests and on GFAP, c-Fos immunoreactivity and glucose metabolism measured in anxiety related brain areas. Artificial rearing of male rats was performed by supplying artificial milk through a cheek cannula and tactile stimulation, mimicking the mother's licking to rat pups from the 4(th) postnatal day until weaning...
October 21, 2017: Developmental Neurobiology
Federico Boschi, Francesco De Sanctis, Antonello E Spinelli
(223) Radium ((223) Ra) is widely used in Nuclear medicine to treat patients with osseous metastatic prostate cancer. In clinical practice (223) Ra cannot be imaged directly, however gamma photons produced by its short-lived daughter nuclides can be captured by conventional gamma cameras. In this work we show that (223) Ra and its short-lived daughter nuclides can be detected with optical imaging techniques. The light emission of (223) Ra was investigated in vitro using different setups in order to clarify the mechanism of light production...
October 20, 2017: Journal of Biophotonics
Reyes Rodenas, Manuel Nieves-Cordones, Rosa María Rivero, Vicente Martinez, Francisco Rubio
Potassium (K(+) ) and Cesium (Cs(+) ) are chemically similar but while K(+) is an essential nutrient, Cs(+) can be toxic for living organisms, plants included. Two different situations could lead to problems derived from the presence of Cs(+) in agricultural systems: (1) presence of Cs(+) at high concentrations that could produce toxic effects on plants and (2) presence of micromolar concentrations of radiocesium, which can be accumulated in the plant and affect animal and human health through the food chain...
October 21, 2017: Physiologia Plantarum
Koichi Takahashi, Kunihiro Yoshisue, Masato Chiba, Takeo Nakanishi, Ikumi Tamai
Trifluridine (FTD) exhibits anticancer activities after its oral administration despite its hydrophilic nature. We previously reported that concentrative nucleoside transporter (CNT) 1 mediates the apical uptake of FTD in human small intestinal epithelial cells (HIECs). In the present study, FTD was also identified as a substrate for equilibrative nucleoside transporter (ENT) 1 and ENT2 in transporter gene-transfected cells. An immunocytochemical analysis revealed that ENT1 was expressed at the basolateral and apical membranes of HIECs...
October 20, 2017: Biopharmaceutics & Drug Disposition
Seog-Young Kim, Jin Hwa Jung, Haeng Jung Lee, Hyunsu Soh, Sang Ju Lee, Seung Jun Oh, Sun Young Chae, Jai Hyuen Lee, Seung Jin Lee, Yong Sang Hong, Tae Won Kim, Dae Hyuk Moon
In cancer therapy, enhanced thymidine uptake by the salvage pathway can bypass dTMP depletion, thereby conferring resistance to thymidylate synthase inhibition. We investigated whether sequential combination therapy of capecitabine and trifluridine/tipiracil (TAS-102) could synergistically enhance antitumor efficacy in colon cancer xenograft models. We also examined 3'-deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT) positron emission tomography (PET) as a means to predict therapeutic response to a sequential combination of capecitabine and trifluridine/tipiracil...
October 20, 2017: Cancer Research
Ahmet Krasniqi, Matthias D'Huyvetter, Catarina Xavier, Kevin Van der Jeught, Serge Muyldermans, José Van Der Heyden, Tony Lahoutte, Jan Tavernier, Nick Devoogdt
Anti-CD20 radioimmunotherapy is an effective approach for therapy of relapsed or refractory CD20pos lymphomas, but faces limitations due to poor tumor penetration and undesirable pharmacokinetics of full antibodies. Camelid single-domain Ab fragments (sdAbs) might circumvent some of the limitations of radiolabeled full antibodies. In this study, a set of hCD20-targeting sdAbs was generated and their capacity to bind hCD20 was evaluated in vitro and in vivo. A lead sdAb, sdAb 9079, was selected based on its specific tumor targeting and significant lower kidney accumulation compared to other sdAbs...
October 20, 2017: Molecular Cancer Therapeutics
Henry H Bernstein, Elisabeth R Seyferth
BACKGROUND: While combination vaccines have contributed to improved vaccine uptake rates in children, studies have documented varied immunogenicity to specific vaccine components. We studied whether varying the amount of tetanus toxoid (TT) in a DTaP and Hib combination vaccine would result in immunogenicity comparable with separate, concurrent administration. METHODS: We evaluated the immunogenicity of Massachusetts Biologic Laboratories (MBL) diphtheria, tetanus, and acellular pertussis (mDTaP) vaccine combined with tetanus-conjugated MBL Haemophilus influenzae type b vaccine (mHib) in a single injection (DTaPH)...
October 17, 2017: Vaccine
D Végh, A Somogyi, D Bányai, M Lakatos, M Balogh, M Al-Khrasani, S Fürst, E S Vizi, P Hermann
Since a significant proportion of diabetic patients have clinical or subclinical neuropathy, there may be concerns about the use of local anaesthetics. The present study was designed to determine and compare the effects of articaine, a widely used anaesthetic in dental practice, and lidocaine on the resting and axonal stimulation-evoked release of [(3)H]noradrenaline ([(3)H]NA) in prefrontal cortex slices and the release of [(3)H]NA in spinal cord slices prepared from non-diabetic and streptozocin (STZ)-induced diabetic (glucose level=22...
October 17, 2017: Brain Research Bulletin
Yitao Zhang, Hongyuan Wang, Qiuliang Lei, Jiafa Luo, Stuart Lindsey, Jizong Zhang, Limei Zhai, Shuxia Wu, Jingsuo Zhang, Xiaoxia Liu, Tianzhi Ren, Hongbin Liu
Optimizing the nitrogen (N) application rate can increase crop yield while reducing the environmental risks. However, the optimal N rates vary substantially when different targets such as maximum yield or maximum economic benefit are considered. Taking the wheat-maize rotation cropping system on the North China Plain as a case study, we quantified the variation of N application rates when targeting constraints on yield, economic performance, N uptake and N utilization, by conducting field experiments between 2011 and 2013...
October 17, 2017: Science of the Total Environment
M K Cox, K N Peterson, D Tan, P J Novak, H L Schoenfuss, J L Ward
Environmental pollutants, including estrogens, are widespread in aquatic environments frequently as a result of treated wastewater effluent discharged. Exposure to estrogens has been correlated with disruption of the normal physiological and reproductive function in aquatic organisms, which could impair the sustainability of exposed populations. However, assessing the effects of estrogen exposure on individuals is complicated by the fact that rates of chemical uptake and environmental degradation are temperature dependent...
October 17, 2017: Science of the Total Environment
Shaoyou Lu, Yuling Yu, Lu Ren, Xiaolan Zhang, Guihua Liu, Yingxin Yu
Increasing concern has been raised in respect of exposure to bisphenols and triclosan (TCS) due to their widespread use. However, little is known about their occurrence in personal care products (PCPs) or, particularly, their dermal uptake following daily application. It is therefore necessary to evaluate the human health risk of bisphenols and TCS via dermal absorption. In this study, 150 PCPs, covering 11 different categories, were collected in China. The concentrations of seven bisphenol analogues and TCS were measured, and the associated human health risks by dermal contact were estimated...
October 17, 2017: Science of the Total Environment
Charlotte Marchand, Michel Mench, Yahya Jani, Fabio Kaczala, Peter Notini, Mohamed Hijri, William Hogland
A pilot scale experiment was conducted to investigate the aided-phytoextraction of metals and the aided-phytodegradation of petroleum hydrocarbons (PHC) in a co-contaminated soil. First, this soil was amended with compost (10% w/w) and assembled into piles (Unp-10%C). Then, a phyto-cap of Medicago sativa L. either in monoculture (MS-10%C) or co-cropped with Helianthus annuus L. as companion planting (MSHA-10%C) was sown on the topsoil. Physico-chemical parameters and contaminants in the soil and its leachates were measured at the beginning and the end of the first growth season (after five months)...
October 17, 2017: Science of the Total Environment
Lei Gao, Weili Zhou, Suqing Wu, Shengbing He, Jungchen Huang, Xu Zhang
This study investigated the potential of thiosulfate-driven autotrophic enhanced floating treatment wetland (AEFTW) in removing nitrogen from the secondary effluent at the relatively short hydraulic retention times and low S/N ratios. Simultaneous autotrophic and heterotrophic denitrification was observed in AEFTW. The peak TN removal rate (15.3gm(-2)d(-1)) exceeded most of the reported floating treatment wetlands. Based on the kinetic model results, low mean temperature coefficient and high k20 verified that the excellent performance in AEFTW diminished the microbial dependence on temperature...
October 17, 2017: Science of the Total Environment
Adriana Seixas, María Fernanda Alzugaray, Lucas Tirloni, Luis Fernando Parizi, Antonio Frederico Michel Pinto, Naftaly Wang'ombe Githaka, Satoru Konnai, Kazuhiko Ohashi, John R Yates Iii, Carlos Termignoni, Itabajara da Silva Vaz
The vitellogenin receptor (VgR), which belongs to the low-density lipoprotein receptors (LDLR) family, regulates the absorption of yolk protein accumulated in developing oocytes during oogenesis. In the present study, the full sequence of Rhipicephalus microplus VgR (RmVgR) and the partial sequence of Rhipicephalus appendiculatus VgR (RaVgR) ORF were determined and cloned. The RmVgR amino acid sequence contains the five highly conserved structural motifs characteristic of LDLR superfamily members, the same overall structure as observed in other species...
October 16, 2017: Ticks and Tick-borne Diseases
Kerui Wu, Fei Xing, Shih-Ying Wu, Kounosuke Watabe
Extracellular vesicles (EVs) have emerged as important players of cancer initiation and progression through cell-cell communication. They have been recognized as critical mediators of extracellular communications, which promote transformation, growth invasion, and drug-resistance of cancer cells. Interestingly, the secretion and uptake of EVs are regulated in a more controlled manner than previously anticipated. EVs are classified into three groups, (i) exosomes, (ii) microvesicles (MVs), and (iii) apoptotic bodies (ABs), based on their sizes and origins, and novel technologies to isolate and distinguish these EVs are evolving...
October 17, 2017: Biochimica et Biophysica Acta
Hiroyuki Kurata, Yurie Sugimoto
Many kinetic models of Escherichiacoli central metabolism have been built, but few models accurately reproduced the dynamic behaviors of wild type and multiple genetic mutants. In 2016 our latest kinetic model improved problems of existing models to reproduce the cell growth and glucose uptake of wild type, ΔpykA:pykF and Δpgi in a batch culture, while it overestimated the glucose uptake and cell growth rates of Δppc and hardly captured the typical characteristics of the glyoxylate and TCA cycle fluxes for Δpgi and Δppc...
October 18, 2017: Journal of Bioscience and Bioengineering
Kari A Duck, Ian A Simpson, James R Connor
Many critical metabolic functions in the brain require adequate and timely delivery of iron. However, most studies when considering brain iron uptake have ignored the iron requirements of the endothelial cells that form the blood-brain barrier (BBB). Moreover, current models of BBB iron transport do not address regional regulation of brain iron uptake or how neurons, when adapting to metabolic demands, can acquire more iron. In this study, we demonstrate that both iron-poor transferrin (apo-Tf) and the iron chelator, deferoxamine, stimulate release of iron from iron-loaded endothelial cells in an in vitro BBB model...
October 17, 2017: Biochemical and Biophysical Research Communications
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