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https://www.readbyqxmd.com/read/29656494/oxidized-ldl-phagocytosis-during-foam-cell-formation-in-atherosclerotic-plaques-relies-on-a-pld2-cd36-functional-interdependence
#1
Ramya Ganesan, Karen M Henkels, Lucile E Wrenshall, Yasunori Kanaho, Gilbert Di Paolo, Michael A Frohman, Julian Gomez-Cambronero
The uptake of cholesterol carried by low-density lipoprotein (LDL) is tightly controlled in the body. Macrophages are not well suited to counteract the cellular consequences of excess cholesterol leading to their transformation into "foam cells," an early step in vascular plaque formation. We have uncovered and characterized a novel mechanism involving phospholipase D (PLD) in foam cell formation. Utilizing bone marrow-derived macrophages from genetically PLD deficient mice, we demonstrate that PLD2 (but not PLD1)-null macrophages cannot fully phagocytose aggregated oxidized LDL (Agg-Ox-LDL), which was phenocopied with a PLD2-selective inhibitor...
April 14, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29656415/focusing-on-cancer-patients-intentions-to-use-psycho-oncological-support-a-longitudinal-mixed-methods-study
#2
T Tondorf, A Grossert, S I Rothschild, M T Koller, C Rochlitz, A Kiss, R Schaefert, G Meinlschmidt, S Hunziker, D Zwahlen
OBJECTIVE: Distress screening programs aim to ensure appropriate psycho-oncological support for cancer patients, but many eligible patients do not use these services. To improve distress management, we need to better understand patients' supportive care needs. In this paper, we report the first key finding from a longitudinal study that focused on patients' intentions to use psycho-oncological support, and its association with distress and uptake of the psycho-oncology service. METHODS: We conducted a prospective, observational study in an Oncology Outpatient Clinic and assessed distress, intention to use psycho-oncological support, and uptake of the psycho-oncology service using the Distress Thermometer (DT), a semi-structured interview, and hospital records...
April 15, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29656358/a-comparative-study-on-defluoridation-capabilities-of-biosorbents-isotherm-kinetics-thermodynamics-cost-estimation-and-eco-toxicological-study
#3
Shraboni Mukherjee, Sujata Dutta, Sourjya Ray, Gopinath Halder
The present study aims towards fluoride remediation from synthetic water using steam-activated carbon of Aegle marmelos (bael shell/wood apple) (BAC) and Parthenium hysterophorus (PHAC) according to batch sorption techniques. The impact of different parametric conditions viz. initial fluoride concentration (4-12 mg/L), time (0-5 h), temperature (293.15-333.15 K), adsorbent dosage (4-14 g/L), pH (4-9), and RPM (150-350) were considered for both the adsorbents. Maximum defluoridation of 89% was achieved by BAC at a concentration of 10 mg/L, adsorbent dose 6 g/L, pH 5, temperature 313...
April 14, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29656354/distribution-relationship-and-risk-assessment-of-toxic-heavy-metals-in-walnuts-and-growth-soil
#4
Yongxiang Han, Zhanglin Ni, Shiliang Li, Minghua Qu, Fubin Tang, Runhong Mo, Caifen Ye, Yihua Liu
Walnut is one of the most popular nuts worldwide and contains various mineral nutrients. Little is known, however, about the relationship between toxic heavy metals in walnuts and growth soil. In this study, we investigated the distribution, relationship, and risk assessment of five toxic heavy metals-lead (Pb), arsenic (As), chromium (Cr), cadmium (Cd), and mercury (Hg)-in walnuts and growth soil in the main production areas of China. The results showed that the main heavy metal pollution in walnut and soil was Pb and Cd...
April 14, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29656353/adsorption-of-cu-ii-and-ni-ii-from-aqueous-solutions-by-taro-stalks-chemically-modified-with-diethylenetriamine
#5
Yao Lu, Deliang He, Huibin Lei, Jun Hu, Houqiang Huang, Huiying Ren
Taro stalks (TS) were modified by diethylenetriamine (DETA) to obtain the modified taro stalks adsorbents (recorded as MTSA). This kind of raw material is unprecedented and the method of modification is relatively simple. The physicochemical properties of MTSA were characterized by scanning electron microscope (SEM), FTIR, and zeta potential analyzer. The capacity of MTSA for adsorbing heavy metals under different influencing factors was tested by UV-visible spectrophotometer. The results indicated that the gaps between the microspheres of MTSA are more, which are conducive to adsorption...
April 14, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29656256/phosphatase-mediated-bioprecipitation-of-lead-as-pyromorphite-by-achromobacter-xylosoxidans
#6
Jaya Sharma, Kashif Shamim, Santosh Kumar Dubey
Achromobacter xylosoxidans strain SJ11, tolerating up to 4.0 mM lead nitrate, in a defined minimal medium was isolated from the waste of a battery manufacturing industry, Goa, India. Interestingly, it formed white precipitate on exposure to lead nitrate which was also evident from scanning electron micrograph (SEM). Energy dispersive X-ray spectroscopic analysis revealed the presence of lead (48.5% by weight) along with phosphorus and chlorine in the precipitate. Transmission electron microscopy (TEM) of bacterial cells clearly refuted the possibility of intracellular lead uptake confirming extracellular precipitation as a predominant mechanism of lead resistance in this bacterium...
April 12, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29656190/effect-of-titanium-dioxide-nanoparticles-on-the-bioavailability-and-neurotoxicity-of-cypermethrin-in-zebrafish-larvae
#7
Meng Li, Qiong Wu, Qiangwei Wang, Dandan Xiang, Guonian Zhu
In aquatic environment, the presence of nanoparticles (NPs) has been reported to modify the bioavailability and toxicity of the organic toxicants. Nevertheless, the combined toxicity of NPs and the pesticides that were used world-widely still remains unclear. Cypermethrin (CYP), a synthetic pyrethroid insecticide, is commonly used for controlling agricultural and indoor pests. Therefore, the effects of titanium dioxide NPs (nTiO2 ) on CYP bioconcentration and its effects on the neuronal development in zebrafish were investigated in our study...
March 31, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29656143/quantitative-imaging-of-bone-cartilage-interactions-in-acl-injured-patients-with-pet-mri
#8
Feliks Kogan, Audrey P Fan, Uche Monu, Andrei Iagaru, Brian A Hargreaves, Garry E Gold
OBJECTIVE: To investigate changes in bone metabolism by PET, as well as spatial relationships between bone metabolism and MRI quantitative markers of early cartilage degradation, in ACL-reconstructed knees. DESIGN: Both knees of 15 participants with unilateral reconstructed ACL tears and unaffected contralateral knees were scanned using a simultaneous 3.0T PET-MRI system following injection of 18 F-sodium fluoride(18 F-NaF). The maximum pixel standardized uptake value(SUVmax ) in the subchondral bone and the average T2 relaxation time in cartilage were measured in each knee in 8 knee compartments...
April 12, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29656028/rice-transcription-factor-osdof11-modulates-sugar-transport-by-promoting-expression-of-sucrose-transporter-and-sweet-genes
#9
Yunfei Wu, Sang-Kyu Lee, Youngchul Yoo, Jinhuan Wei, Suk-Yoon Kwon, Sang-Won Lee, Jong-Seong Jeon, Gynheung An
Sucrose is produced in mesophyll cells and transferred into phloem cells before it is delivered long-distance to sink tissues. However, little is known about how sucrose transport is regulated in plants. Here, we identified T-DNA insertional mutants in Oryza sativa DNA BINDING WITH ONE FINGER 11 (OsDOF11), which is expressed in the vascular cells of photosynthetic organs and in various sink tissues. The osdof11 mutant plants are semi-dwarf and have fewer tillers and smaller panicles. Although sucrose enhanced root elongation in young wild-type (WT) seedlings, this did not occur in osdof11 seedlings due to reduced sucrose uptake...
April 12, 2018: Molecular Plant
https://www.readbyqxmd.com/read/29655983/catalytic-asymmetric-synthesis-of-%C3%AE-methyl-p-boronophenylalanine
#10
Shingo Harada, Ryota Kajihara, Risa Muramoto, Promsuk Jutabha, Naohiko Anzai, Tetsuhiro Nemoto
p-Boronophenylalanine (l-BPA) is applied in clinical settings as a boron carrier for boron neutron capture therapy (BNCT) to cure malignant melanomas. Structural modification or derivatization of l-BPA, however, to improve its uptake efficiency into tumor cells has scarcely been investigated. We successfully synthesized (S)-2-amino-3-(4-boronophenyl)-2-methylpropanoic acid in enantioenriched form as a novel candidate molecule for BNCT. Key steps to enhance the efficiency of this synthesis were enantioselective alkylation of N-protected alanine tert-butyl ester with a Maruoka catalyst and Miyaura borylation reaction to install the boron functionality...
March 28, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29655884/lignin-based-hydrogels-with-super-swelling-capacities-for-dye-removal
#11
Juan Domínguez-Robles, María Soledad Peresin, Tarja Tamminen, Alejandro Rodríguez, Eneko Larrañeta, Anna-Stiina Jääskeläinen
Lignin is a complex natural polymer and it is one of the main constituent of the lignocellulosic biomass. Moreover, it is a bio-renewable material and it is available in large amounts as by-product of residues from the wood and paper industries. Lignin-based hydrogels with high swelling capabilities were prepared by crosslinking poly (methyl vinyl ether co‑maleic acid) and different technical lignins in ammonium and sodium hydroxide solutions. The produced hydrogels showed a wide range of water absorption capacities varying from 13 to 130 g of water per 1 g of sample...
April 12, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29655866/activation-of-gsk3%C3%AE-%C3%AE-trcp-axis-via-phlpp1-exacerbates-nrf2-degradation-leading-to-impairment-in-cell-survival-pathway-during-diabetic-nephropathy
#12
Alpana Mathur, Vivek Kumar Pandey, Poonam Kakkar
NF-E2 p45-related factor 2 (Nrf2), is a major redox sensitive transcription factor that plays an essential role in regulating glucose metabolism. Inactivation of Nrf2 has been associated with diabetic complications however, mechanisms warranting Nrf2 suppression are incompletely understood. We hypothesized that PHLPP1 activates GSK3β to induce β-TrCP mediated Nrf2 phosphorylation and degradation. In vivo study was carried out in STZ-NA induced type 2 diabetic male Wistar rats. GSK3β mediated Nrf2 ubiquitination was confirmed by administration of GSK3β inhibitor (LiCl; 60mg/kg bwt...
April 12, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29655795/enhanced-oral-absorption-of-sorafenib-via-the-layer-by-layer-deposition-of-a-ph-sensitive-polymer-and-glycol-chitosan-on-the-liposome
#13
Mengjia Zhao, Sang Hoon Lee, Jae Geun Song, Hyeon Young Kim, Hyo-Kyung Han
This study aimed to design the effective formulation of sorafenib (SF) to enhance the oral drug absorption. Three liposomal formulations of SF were prepared including uncoated liposome (SF-Lip), glycol chitosan-coated liposome (GC-SF-Lip), and Eudragit S100-glycol-chitosan coated liposome (SGC-SF-Lip). All formulations showed a narrow size distribution with a high encapsulation efficiency. Both GC-SF-Lip and SGC-SF-Lip exhibited good stability at acidic and neutral pHs without any significant drug leakage, while SF-Lip appeared to be unstable at pH 1...
April 12, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29655757/fucoxanthin-bioavailability-from-fucoxanthin-fortified-milk-in-vivo-and-in-vitro-study
#14
Il-Kyoon Mok, Jae Kwon Lee, Jeong Hwa Kim, Cheol-Ho Pan, Sang Min Kim
Our previous study reported the improved stability of fucoxanthin (FX) fortified in whole milk (WM) and skimmed milk (SM). In this study, in vivo and in vitro FX bioavailability were investigated using FX-fortified milk (FX-SM and FX-WM) and microalga Phaeodactylum tricornutum biomass (Pt-powder). Organ tissue accumulation of FX and its metabolites (FXOH: fucoxanthinol, AXA: amarouciaxanthin A) after repeated oral administration was in the following order: FX-SM > FX-WM > Pt-powder. In vivo pharmacokinetic study with a single oral administration also demonstrated that the absorption of FXOH and AXA was the highest for FX-SM...
August 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29655677/an-in-vitro-and-in-vivo-study-of-a-4-herb-formula-on-the-management-of-diet-induced-metabolic-syndrome
#15
Elaine Wat, Yanping Wang, Ken Chan, Hon Wai Law, Chi Man Koon, Kit Man Lau, Ping Chung Leung, Choly Yan, Clara Bik San Lau
BACKGROUND: Metabolic syndrome is the cluster of risk factors that leads to increased episodes of cardiovascular disease (CVD). These risk factors include but are not limited to obesity, non-alcoholic fatty liver (NAFLD), dyslipidemia, and type 2 diabetes. Since the pathogenesis of metabolic syndrome has multiple metabolic origins, there is no single treatment for it. Pharmacological approaches consist of separate drugs which target at individual risk factors which pose various side effects...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29655628/trends-in-diarrhea-hospitalizations-among-infants-at-three-hospitals-in-tanzania-before-and-after-rotavirus-vaccine-introduction
#16
Faraja Lyamuya, Fausta Michael, Bhavin Jani, Yohana Fungo, Alfred Chambo, Inviolatha Chami, Regina Bulali, Amina Mpamba, Happy Cholobi, Dotto Kallovya, Christopher Kamugisha, Jason M Mwenda, Margaret M Cortese
BACKGROUND: The Tanzania Ministry of Health introduced monovalent human rotavirus vaccine in January 2013, to be administered at ages 6 and 10 weeks. Data suggest there was high vaccine uptake. We used hospital ward registers from 3 hospitals to examine trends in diarrhea hospitalizations among infants before and after vaccine introduction. METHODS: Ward registers from Dodoma Regional Referral Hospital (Central Tanzania), and two hospitals in Mbeya (Southwest area), Mbeya Zonal Referral Hospital and Mbalizi Hospital, were used to tally admissions for diarrhea among children by age group, month and year...
April 11, 2018: Vaccine
https://www.readbyqxmd.com/read/29655611/development-of-a-ga-68-labeled-pet-tracer-with-short-linker-for-prostate-specific-membrane-antigen-psma-targeting
#17
Sung-Hyun Moon, Mee Kyung Hong, Young Ju Kim, Yun-Sang Lee, Dong Soo Lee, June-Key Chung, Jae Min Jeong
Glu-Urea-Lys (GUL) derivatives have been reported as prostate-specific membrane antigen (PSMA) agent. We developed derivatives of GUL conjugated with NOTA or DOTA via a thiourea linker and tested their feasibility as PSMA imaging agents after labeling with 68 Ga. NOTA-GUL and DOTA-GUL were synthesized and labeled with 68 Ga using generator-eluted 68 GaCl3 in 0.1 M HCl in the presence of 1 M NaOAc at pH 5.5. The stabilities of 68 Ga-labeled compounds in human serum were tested at 37.5 °C. A competitive binding assay was performed using the PSMA-positive prostate cancer cell line 22Rv1 and [125 I]MIP-1072 (PSMA-specific binding agent) as a tracer...
April 5, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29655459/adiponectin-and-its-isoforms-in-pathophysiology
#18
Merel van Andel, Annemieke C Heijboer, Madeleine L Drent
Adiponectin circulates in blood in multiple isoforms. High molecular weight (HMW) adiponectin is thought to be most biologically active and promotes glucose uptake, insulin sensitivity, and fatty acid oxidation. In obesity, adiponectin isoform formation is disrupted, leading to an inverse association between metabolic disease and HMW and total adiponectin. Adiponectin isoforms also function as acute-phase reactants influencing inflammation in acute and chronic disease. Interestingly, adiponectin and mortality have a U-shaped association...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29653435/functional-characterization-of-the-gene-promoter-for-an-elaeis-guineensis-phosphate-starvation-inducible-high-affinity-phosphate-transporter-in-both-homologous-and-heterologous-model-systems
#19
Farzaneh Ahmadi, Siti Nor Akmar Abdullah, Saeid Kadkhodaei, Siti Mariyam Ijab, Luqman Hamzah, Maheran Abdul Aziz, Zaharah A Rahman, Sharifah Shahrul Rabiah Syed Alwee
Oil palm is grown in tropical soils with low bioavailability of Pi. A cDNA clone specifically expressed under phosphate-starvation condition in oil palm roots was identified as a high-affinity phosphate transporter (EgPHT1). The deduced amino acid sequence has 6 transmembrane domains each at the N- and C-termini separated by a hydrophilic linker. Comparison of promoter motifs within 1500 bp upstream of ATG of 10 promoters from high- and low-affinity phosphate transporter from both dicots and monocots including EgPHT1 was performed...
April 9, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29653373/combined-effect-of-salt-and-drought-on-boron-toxicity-in-puccinellia-tenuiflora
#20
Chunguang Liu, Zheng Dai, Jingye Xia, Can Chang, Hongwen Sun
Boron toxicity is a worldwide problem, usually accompanied by salt (NaCl) and drought. The combined stresses may induce complex toxicity to the plant. The aim of the present study was to investigate how the combined stresses of salt and drought affect B toxicity in plants. Puccinellia tenuiflora seedlings were planted in vermiculite. A three (B) × three (salt) × three (drought) factorial experiment (for a total of 27 treatments) was conducted. After a 30-day cultivation, plants were harvested to determine dry weight and the concentrations of B, Na+ , K+ , Ca2+ , and Mg2+ ...
April 10, 2018: Ecotoxicology and Environmental Safety
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