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https://www.readbyqxmd.com/read/28654748/preparation-of-poly-styrene-b-poly-acrylic-acid-coupled-carbon-dots-and-their-applications
#1
Moon-Jin Cho, Soo-Young Park
Carbon dots (CDs) are covalently coupled to the polyacrylic acid (PAA) block of polystyrene-b-polyacrylic acid (PS-b-PAA). The produced amphiphilic PS-b-PAA-CD shows excellent solubility and micellar formation in selective solvents. Transmission electron microscopy study shows that the micelle of PS-b-PAA-CD in water (a PAA-selective solvent) has a strawberry-like shape with the CDs as patches on the PAA corona surface although that in toluene (a PS-selective solvent) has a reversed shape with the CDs in the core...
June 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28653961/subtleties-of-catanionic-surfactant-reverse-micelle-assemblies-revealed-by-a-fluorescent-molecular-probe
#2
Cristian C Villa, Juana J Silber, Ruben Dario Falcone, N Mariano Correa
In this work, the absorption and emission behavior of the cationic hemicyanine trans-4-[4-(dimethylamino)styryl]-N-methylpyridinium iodide (HC) in reverse micelles (RMs) formed by the catanionic surfactants: benzyl-n-hexadecyldimethylammonium-1,4-bis-2-ethylhexylsulfosuccinate (AOT-BHD) and cetyltrimethylammonium-1,4-bis-2-ethylhexylsulfosuccinate (AOT-CTA) has been investigated. Our results show that the HC spectroscopic behavior changes when the dye is dissolved in AOT-BHD or in AOT-CTA RMs. While HC undergoes an intramolecular charge-transfer process upon excitation in AOT-CTA RMs, in AOT-BHD RMs this process is inhibited due to a specific interaction between HC and the polar head group of the BHD+ cation...
June 27, 2017: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/28653804/opening-a-can-of-worm-like-micelle-s-the-effect-of-temperature-of-solutions-of-functionalised-dipeptides
#3
Dave John Adams, Emily Draper, Hao Su, Christopher Brasnett, Robert Poole, Sarah Rogers, Honggang Cui, Annela Seddon
A simple heat and cool cycle can be used to significantly affect the properties of a solution of a low molecular weight gelator at high pH. The viscosity and extensional viscosity are increased markedly, leading to materials with very different properties than when the native solution is used.
June 27, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28652732/preparation-characterization-and-evaluation-of-amphotericin-b-loaded-mpeg-pcl-g-pei-micelles-for-local-treatment-of-oral-candida-albicans
#4
Li Zhou, Peipei Zhang, Zhuo Chen, Shaona Cai, Ting Jing, Huihui Fan, Fei Mo, Jiye Zhang, Rong Lin
Fatal Candida albicans infections in the mucosal system can occur in association with immune-compromised diseases and dysbacteriosis. Currently, amphotericin B (AmB) is considered to be the most effective antibiotic in the treatment of C. albicans infections, but its clinical application is limited by side effects and poor bioavailability. In order to use AmB in the local treatment of oral C. albicans infections, AmB/MPEG-PCL-g-PEI (monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-graft-polyethylenimine, MPP) micelles were prepared...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28651240/indirect-spectrophotometric-determination-of-sulfadiazine-based-on-localized-surface-plasmon-resonance-peak-of-silver-nanoparticles-after-cloud-point-extraction
#5
Elahe Kazemi, Shayessteh Dadfarnia, Ali Mohammad Haji Shabani, Mohammad Reza Fattahi, Javad Khodaveisi
A novel, efficient, easy to use, environmentally friendly and cost-effective methodology is developed for the indirect spectrophotometric determination of sulfadiazine in different samples. The method is based on the micelle-mediated extraction of silver sulfadiazine and converting the silver content of the resultant surfactant-rich phase to the silver nanoparticles via generation of [Ag(NH3)2](+) followed by its chemical reduction using ascorbic acid. The changes in the amplitude of localized surface plasmon resonance peak of silver nanoparticles as a function of sulfadiazine concentration in the sample solution was monitored using fiber optic linear array spectrophotometry at 457nm...
June 17, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28650666/labile-incorporation-of-cholesterol-terminated-poly-acrylic-acid-for-the-facile-surface-modification-of-lipid-vesicles
#6
Sang-Min Lee
An amphiphilic cholesterol-terminated poly[acrylic acid] (Chol-PAA) that can be self-aggregated into nanoscale micelles in aqueous media has been prepared via nitroxide-mediated radical polymerization for the facile postformation modification of lipid vesicles. By varying the amount of Chol-PAA addition, the incorporation of Chol-PAA on the liposome templates was verified with zeta potential while the dynamic light scattering measurements revealed the polymer length of Chol-PAA dictated the hydrodynamic diameter of the resulting polymer-grafted vesicles (PGVs)...
June 26, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28650154/interrogating-detergent-desolvation-of-nanopore-forming-proteins-by-fluorescence-polarization-spectroscopy
#7
Aaron J Wolfe, Yi-Ching Hsueh, Adam R Blanden, Mohammad M Mohammad, Bach Pham, Avinash Kumar Thakur, Stewart N Loh, Min Chen, Liviu Movileanu
Understanding how membrane proteins interact with detergents is of fundamental and practical significance in structural and chemical biology as well as in nanobiotechnology. Current methods for inspecting protein-detergent complex (PDC) interfaces require high concentrations of protein and are of low throughput. Here, we describe a scalable, spectroscopic approach that uses nanomolar protein concentrations in native solutions. This approach, which is based on steady-state fluorescence polarization (FP) spectroscopy, kinetically resolves the dissociation of detergents from membrane proteins and protein unfolding...
June 26, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28650116/polymeric-drug-delivery-systems-for-intraoral-site-specific-chemoprevention-of-oral-cancer
#8
REVIEW
Kashappa Goud H Desai
Oral cancer is among the most prevalent cancers in the world. Moreover, it is one of the major health problems and causes of death in many regions of the world. The traditional treatment modalities include surgical removal, radiation therapy, systemic chemotherapy, or a combination of these methods. In recent decades, there has been significant interest in intraoral site-specific chemoprevention via local drug delivery using polymeric systems. Because of its easy accessibility and clear visibility, the oral mucosa is amenable for local drug delivery...
June 26, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28649998/uniform-electroactive-fibre-like-micelle-nanowires-for-organic-electronics
#9
Xiaoyu Li, Piotr J Wolanin, Liam R MacFarlane, Robert L Harniman, Jieshu Qian, Oliver E C Gould, Thomas G Dane, John Rudin, Martin J Cryan, Thomas Schmaltz, Holger Frauenrath, Mitchell A Winnik, Charl F J Faul, Ian Manners
Micelles formed by the self-assembly of block copolymers in selective solvents have attracted widespread attention and have uses in a wide variety of fields, whereas applications based on their electronic properties are virtually unexplored. Herein we describe studies of solution-processable, low-dispersity, electroactive fibre-like micelles of controlled length from π-conjugated diblock copolymers containing a crystalline regioregular poly(3-hexylthiophene) core and a solubilizing, amorphous regiosymmetric poly(3-hexylthiophene) or polystyrene corona...
June 26, 2017: Nature Communications
https://www.readbyqxmd.com/read/28648865/self-assembled-amphiphilic-core-shell-nanocarriers-in-line-with-the-modern-strategies-for-brain-delivery
#10
REVIEW
Reham S Elezaby, Heba A Gad, Abdelkader A Metwally, Ahmed S Geneidi, Gehanne A Awad
Disorders of the central nervous system (CNS) represent increasing social and economic problems all over the world which makes the effective transport of drugs to the brain a crucial need. In the last decade, many strategies were introduced to deliver drugs to the brain trying to overcome the challenge of the blood brain barrier (BBB) using both invasive and non-invasive methods. Non-invasive strategy represented in the application of nanocarriers became very common. One of the most hopeful nanoscopic carriers for brain delivery is core-shell nanocarriers or polymeric micelles (PMs)...
June 22, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28648579/release-mechanism-of-doxazosin-from-carrageenan-matrix-tablets-effect-of-ionic-strength-and-addition-of-sodium-dodecyl-sulphate
#11
Petra Kos, Matej Pavli, Saša Baumgartner, Ksenija Kogej
The polyelectrolyte matrix tablets loaded with an oppositely charged drug exhibit complex drug-release mechanisms. In this study, the release mechanism of a cationic drug doxazosin mesylate (DM) from matrix tablets based on an anionic polyelectrolyte λ-carrageenan (λ-CARR) is investigated. The drug release rates from λ-CARR matrices are correlated with binding results based on potentiometric measurements using the DM ion-sensitive membrane electrode and with molecular characteristics of the DM-λ-CARR-complex particles through hydrodynamic size measurements...
June 22, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28648521/ratiometric-co-delivery-of-multiple-chemodrugs-in-a-single-nanocarrier
#12
Chao Chen, Ran Tao, Dan Ding, Deling Kong, Aiping Fan, Zheng Wang, Yanjun Zhao
Co-delivery of multiple anti-cancer drugs in a single nanoplatform has shown great promise in enhancing therapeutic efficacy and reducing adverse effects. However, the ratiometric dose control is pivotal, but often challenging in combinational nanomedicine. Here, we report the employment of cyclodextrin-bearing amphiphilic polymer conjugate micelles for ratiometric, non-covalent loading of three hydrophobic model drugs, curcumin (CUR), camptothecin (CPT), and doxorubicin (DOX) in one single nanocarrier. Each drug was physically encapsulated in the cyclodextrin-bearing polymer conjugate via guest-host complexation...
June 22, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28647330/effect-of-high-hydrostatic-pressure-treated-skim-milk-on-permeate-flux-and-fouling-during-ultrafiltration
#13
Mathilde Leu, Alice Marciniak, Julien Chamberland, Yves Pouliot, Laurent Bazinet, Alain Doyen
Ultrafiltration (UF) is largely used in the dairy industry to generate milk and whey protein concentrate for standardization of milk or production of dairy ingredients. Recently, it was demonstrated that high hydrostatic pressure (HHP) extended the shelf life of milk and improved rennet coagulation and cheese yield. Pressurization also modified casein micelle size distribution and promoted aggregation of whey proteins. These changes are likely to affect UF performance. Consequently, this study will determine the effect of skim milk pressurization (300 and 600 MPa, 5 min) on UF performance in terms of permeate flux decline and fouling...
June 21, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28647329/structural-changes-induced-by-high-pressure-processing-in-micellar-casein-and-milk-protein-concentrates
#14
Lee Cadesky, Markus Walkling-Ribeiro, Kyle T Kriner, Mukund V Karwe, Carmen I Moraru
Reconstituted micellar casein concentrates and milk protein concentrates of 2.5 and 10% (wt/vol) protein concentration were subjected to high-pressure processing at pressures from 150 to 450 MPa, for 15 min, at ambient temperature. The structural changes induced in milk proteins by high-pressure processing were investigated using a range of physical, physicochemical, and chemical methods, including dynamic light scattering, rheology, mid-infrared spectroscopy, scanning electron microscopy, proteomics, and soluble mineral analyses...
June 21, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28643367/facile-one-pot-synthesis-of-functional-giant-polymeric-vesicles-controlled-by-oscillatory-chemistry
#15
Bishnu Bastakoti, Juan Perez-Mercader
We introduce a novel application of an oscillatory chemical reaction to the synthesis of block copolymers. The Belousov-Zhabotinsky (B-Z) reaction is coupled with the polymerization of an amphiphilic block copolymer. Radicals generated in the B-Z reaction initiate the polymerization between a polyethylene glycol (PEG) macro reversible addition-fragmentation chain transfer agent and butyl acrylate monomers. The growth of the hydrophobic block on PEG undergoes self-assembly to form spherical micelles. The nanoscale micelles transform into submicron vesicles and grow to giant vesicles as a consequence of the oscillatory behavior of the B-Z reaction...
June 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28643192/on-the-kinetics-of-body-versus-end-evaporation-and-addition-of-supramolecular-polymers
#16
Nitin S Tiwari, Paul van der Schoot
The kinetics of the self-assembly of supramolecular polymers is dictated by how monomers, dimers, trimers etc., attach to and detach from each other. It is for this reasons that researchers have proposed a plethora of pathways to explain the kinetics of various self-assembling supramolecules, including sulfur, linear micelles, living polymers and protein fibrils. Recent observations hint at the importance of a hitherto ignored molecular aggregation pathway that we refer to as "body evaporation and addition"...
June 2017: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/28643001/prediction-of-self-assemblies-of-sodium-dodecyl-sulfate-and-fragrance-additives-using-coarse-grained-force-fields
#17
Chunwei Yang, Zhe Shen, Liang Wu, Haiqiu Tang, Lifeng Zhao, FengLei Cao, Huai Sun
Coarse-grained force field (CGFF) methods were applied to study the self-assembly of sodium dodecyl sulfate with fragrance additives. The CGFF parameters were parameterized and validated using experimental and all-atom simulation data. Direct molecular dynamics simulations were carried out to characterize the initial aggregation, partitioning of fragrances, and chemical potentials of the surfactant and fragrance molecules in aggregates of different sizes. The equilibrium critical micelle concentrations (CMCs) and micelle size distributions, which could not be obtained by direct simulation, were predicted using the calculated chemical potentials in combination with a thermodynamic model...
July 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28643000/interaction-of-the-interleukin-8-protein-with-a-sodium-dodecyl-sulfate-micelle-a-computer-simulation-study
#18
Hector Dominguez
Molecular simulations were carried out to study the sodium dodecyl sulfate (SDS) surfactant with the interleukin 8 (IL8) protein as a model to investigate the influence of amphiphilic molecules on proteins. Simulations for an SDS micelle with an IL8 protein show that both aggregates, which were initially separated, eventually approach each other to form a single complex. The results showed that the protein was attached to the SDS micelle by the charged positive amino acids whereas less contacts were observed for the negatively charged amino acids...
July 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28641543/zein-based-nanocarriers-as-potential-natural-alternatives-for-drug-and-gene-delivery-focus-on-cancer-therapy
#19
Ahmed Elzoghby, May Freag, Hadeer Mamdouh, Kadria Elkhodairy
Protein nanocarriers possess unique merits including minimal cytotoxicity, numerous renewable sources, and high drug-binding capability. In opposition to delivery carriers utilizing hydrophilic animal proteins, hydrophobic plant proteins (e.g, zein) have great tendency in fabricating controlled-release particulate carriers without additional chemical modification to stiffen them, which in turn evades the use of toxic chemical crosslinkers. Moreover, zein is related to a class of alcohol-soluble prolamins and generally recognized as safe (GRAS) carrier for drug delivery...
June 22, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28640613/molecular-recognition-under-interfacial-conditions-calix-4-pyrrole-based-cross-linkable-micelles-for-ion-pair-extraction
#20
Xiaodong Chi, Gretchen Marie Peters, Forrest Hammel, Chandler Brockman, Jonathan L Sessler
An anthracene-functionalized, long-tailed calix[4]pyrrole 1, containing both an anion-recognition site and cation-recognition functionality, has been synthesized and fully characterized. Upon ion-pair complexation with FeF2, receptor 1 self-assembles into multi-micelles in aqueous media. This aggregation process is ascribed to a change in polarity from non-polar to amphiphilic induced upon concurrent anion and cation complexation and permits molecular recognition-based control over chemical morphology under interfacial conditions...
June 22, 2017: Journal of the American Chemical Society
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