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https://www.readbyqxmd.com/read/28544958/impact-of-triblock-copolymers-on-the-biophysical-function-of-naturally-derived-lung-surfactant
#1
Moritz Beck-Broichsitter, Christian A Ruge, Adam Bohr
The current study aimed at investigating the general applicability of triblock copolymers consisting of poly(ethylene glycol) and poly(propylene glycol) (Pluronic(®)) as excipients for lung delivery. After thorough physicochemical characterization of the diverse polymers, their cytotoxicity was evaluated using alveolar epithelial cells. Next, a naturally-derived lung surfactant was challenged with the distinct triblock copolymers with respect to changes in microstructure, adsorption to the air/liquid interface and dynamic surface tension behavior under bubble pulsation...
May 17, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28544434/strain-stiffening-hydrogels-through-self-assembly-and-covalent-fixation-of-semi-flexible-fibers
#2
Rint P Sijbesma, Marcos Fernandez-Castano Romera, Clément Guibert, Ilja K Voets, Cornelis Storm
Biomimetic, strain-stiffening materials are reported, made through self-assembly and covalent fixation of small building blocks to form fibrous hydrogels able to stiffen by an order of magnitude in response to applied stress. The gels consist of semi-flexible rodlike micelles of bisurea bolaamphiphiles with oligo(ethylene oxide) (EO) outer blocks and a polydiacetylene (PDA) backbone. The micelles are fibers composed of 9-10 ribbons. A gelation method based on Cu-catalyzed azide-alkyne cycloaddition (CuAAC) was developed that leads to strain-stiffening hydrogels with unusual yet universal linear and nonlinear stress-strain response...
May 24, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28541676/double-sweeping-highly-effective-sample-preconcentration-using-cationic-and-anionic-micelles-and-its-application-to-a-multiple-enzyme-activity-assay
#3
Ryota Sanuki, Kenji Sueyoshi, Tatsuro Endo, Hideaki Hisamoto
In conventional microfluidic bioassays, short optical pathlength and extremely small quantities of analytes sometimes can significantly reduce detectability. Various sample preconcentration techniques have been reported for improving the detectability of bioassays. In the present study, we developed a novel preconcentration technique, 'double sweeping', utilizing cationic and anionic micelles simultaneously. Microscopic observations demonstrated that double sweeping enabled a sample solution, which initially filled a capillary, to be focused into an extremely narrow band...
May 25, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28541038/conical-ionic-amphiphiles-endowed-with-micellization-ability-but-lacking-air-and-oil-water-interfacial-activity
#4
Hirohisa Nitta, Koji Harano, Mayuko Isomura, Ellen H G Backus, Mischa Bonn, Eiichi Nakamura
Micellization in water and reduction of the surface tension of water interfaces with air and oil are two archetypical properties of surfactants, caused by self-aggregation and Gibbs monolayer formation at the interfaces, respectively. We present here a new type of amphiphiles that possess a conical shape consisting of a hydrophobic apex and five ionic termini at its base of the cone. The conical shape and the high charge density cooperatively impede the monolayer formation at the interfaces, and hence prevent foaming and emulsification...
May 25, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28541037/phase-behavior-of-salt-free-polyelectrolyte-gel-surfactant-systems
#5
Martin Andersson, Per Hansson
Ionic surfactants tend to collapse the outer parts of polyelectrolyte gels, forming shells that can be used to encapsulate other species including protein and peptide drugs. In this paper the aqueous phase behaviour of covalently crosslinked polyacrylate networks containing sodium ions and dodecyltrimethylammonium ions as counterions is investigated by means of swelling isotherms, dye staining, small-angle x-ray scattering and confocal Raman spectroscopy. The equilibrium state is approached by letting the networks absorb pure water...
May 25, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28540720/specifically-increased-paclitaxel-release-in-tumor-and-synergetic-therapy-by-a-hyaluronic-acid-tocopherol-nanomicelle
#6
Hanbo Zhang, Wei Li, Xiaomeng Guo, Fenfen Kong, Zuhua Wang, Chunqi Zhu, Lihua Luo, Qingpo Li, Jie Yang, Yongzhong Du, Jian You
Recently, interest in tumor-targeting and site-specific drug release from nanoparticles as a means of drug delivery has increased. In this study, we reported on a smart nanosized micelle formed by hyaluronic acid (HA) conjugated with D-α-Tocopherol Succinate (TOS) using a disulfide bond as the linker (HA-SS-TOS, HSST). HSST micelles can specifically bind to the CD44 receptors that are overexpressed on cancer cells. The high levels of glutathione (GSH) in tumor cells selectively break the disulfide bond linker...
May 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28540381/lipoic-acid-based-core-cross-linked-micelles-for-multivalent-platforms-design-synthesis-and-application-in-bio-imaging-and-drug-delivery
#7
Jingsheng Huang, Fang Wu, Yunlong Yu, Haolong Huang, Shiyong Zhang, Jingsong You
Natural lipoic acid derived small-molecule amphiphiles self-assemble into micelles in water. The presence of numerous disulfides accumulated in the core makes the micelles readily cross-linked to achieve the establishment of core cross-linked micelles (CCMs). Thanks to the inherent biocompatibility, the resulting lipoic acid based CCMs (LA-CCMs) are good multivalent platforms for biomedical applications.
May 25, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28539273/ion-paired-pirenzepine-loaded-micelles-as-an-ophthalmic-delivery-system-for-the-treatment-of-myopia
#8
Yanan Li, Yong Zhang, Pengmei Li, Gujie Mi, Jiasheng Tu, Linlin Sun, Thomas J Webster, Yan Shen
Myopia is one of the most common ocular disorders for which standard treatments, such as refractive surgery, often involve invasive procedures. Pirenzepine (PRZ), a muscarinic receptor antagonist, has been recognized as a promising candidate for the treatment of myopia, but possesses poor ocular bioavailability. The overall objective of this study was to prepare PRZ-sorbic acid complexes suitable to be encapsulated into micelles with high efficiency for optimal ophthalmic delivery. The results demonstrated that sorbic acid, used as the counter ion, had the most significant effects in increasing octanol-water distribution coefficient of PRZ as well as improving its corneal permeability in vitro among various counter ions tested...
May 21, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28539048/thermochromic-ion-exchange-micelles-containing-h-chromoionophores
#9
Xinfeng Du, Changyou Zhu, Xiaojiang Xie
Thermochromic composites constitute a classical subfamily of stimuli responsive materials. We report here the thermochromic effect in Pluronic F-127 (F127) micelles containing hydrophobic ion-exchanger and H(+) chromoionophores. The highly versatile and reversible thermochromism is attributed to the temperature-induced hydration-dehydration of the peripheral layer of the micelles, which in turn controls the ion-exchange process between the core and the periphery of the micelles. The color typically changes abruptly within 3 to 5 degree Celsius and the color transition temperature can be tuned within 5 to 25 degree Celsius upon varying the F127 concentrations...
May 24, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28537736/probing-the-cleaning-of-polymeric-coatings-by-nanostructured-fluids-a-qcm-d-study
#10
Martina Raudino, Nicoletta Giamblanco, Costanza Montis, Debora Berti, Giovanni Marletta, Piero Baglioni
Complex fluids composed of water, an organic solvent and a surfactant have been recently employed as cleaning systems to remove hydrophobic materials, such as polymeric coatings, from solid surfaces. The simultaneous presence of surfactants and an organic solvent with good affinity for the polymer was proven necessary for the polymer's removal, but the comprehension of the cleaning mechanism is poorly understood. In this article we investigated the mechanism of removal, highlighting the specific role of each component in the interaction with the polymer film...
May 24, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28537295/imprinted-micelles-for-chiral-recognition-in-water-shape-depth-and-number-of-recognition-sites
#11
Joseph K Awino, Yan Zhao
Chiral molecular recognition is important to biology, separation, and asymmetric catalysis. Because there is no direct correlation between the chiralities of the host and the guest, it is difficult to design a molecular receptor for a chiral guest in a rational manner. By cross-linking surfactant micelles containing chiral template molecules, we obtained chiral nanoparticle receptors for a number of 4-hydroxyproline derivatives. Molecular imprinting allowed us to transfer the chiral information directly from the guest to host, making the molecular recognition between the two highly predictable...
May 24, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28536791/hexafluoroisopropanol-mediated-cloud-point-extraction-of-organic-pollutants-in-water-with-analysis-by-high-performance-liquid-chromatography
#12
Jia Xu, Yunfang Li, Cao Li, Rui Zhang, Yuxiu Xiao
A hexafluoroisopropanol (HFIP)-mediated cloud point extraction (CPE) system was established. A small amount of HFIP (even 1%, v/v) can dramatically reduce the cloud point of Triton X-100 (TX-100) aqueous solution (even to 1 °C) and make liquid-liquid two-phase separation (coacervate phase and aqueous phase) occur at room temperature over a wide range of TX-100 concentration (0.5∼10%, g/mL). HFIP-mediated coacervate phase has smaller volume (volume ratio is 1.8∼8.9% relative to the volume of the total solution with 1∼5% TX-100) and larger micelle aggregates (30∼80 nm in diameter) compared to temperature-induced coacervate phase (volume ratio at 2...
May 24, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28536008/chemosensitization-and-inhibition-of-pancreatic-cancer-stem-cell-proliferation-by-overexpression-of-microrna-205
#13
Amit Kumar Chaudhary, Goutam Mondal, Virender Kumar, Krishna Kattel, Ram I Mahato
Treatment of pancreatic cancer with gemcitabine (GEM) is limited due to its rapid plasma metabolism and development of chemoresistance. MicroRNA (miRNA) regulates cancer stem cell (CSC) maintenance and induces chemoresistance in cancer cells. In this study, we observed differential downregulation of miR-205 (miR-205-5p) in human pancreatic cancer tissues and cells. Compared to GEM-sensitive MIA PaCa-2 cells, miR-205 was highly downregulated in GEM-resistant MIA PaCa-2R cells. Lentivirus-mediated overexpression of miR-205 inhibits MIA PaCa-2R cell proliferation after GEM-treatment...
May 20, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28535067/emulsion-polymerization-with-a-biosurfactant
#14
Aya Kurozuka, Shohei Onishi, Takuto Nagano, Katsumi Yamaguchi, Toyoko Suzuki, Hideto Minami
Emulsion polymerization of styrene was conducted using a biosurfactant (i.e., sodium surfactin, hereinafter called just "surfactin") having very low critical micelle concentration (CMC, 2.9 × 10-3 mmol/L) and biodegradability characteristics. The nucleation mechanism was investigated by comparing with a conventional surfactant (i.e., sodium dodecyl sulfate, SDS) system. Unlike the emulsion polymerization systems using conventional surfactants, nucleation mechanisms changed above CMC in the presence of a biosurfactant...
May 23, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28534622/solute-partitioning-in-micelles-combining-molecular-dynamics-simulations-cosmomic-and-experiments
#15
Denitsa Yordanova, Eric Ritter, Thomas Gerlach, Jan-Hendrik Jensen, Irina Smirnova, Sven Jakobtorweihen
The partition equilibria of solutes between micelles and an aqueous phase is a key factor in many applications. Depending on the task, many micelle-solute combinations are possible. Therefore, theoretical methods to predict the partition behavior in micellar systems are needed. Here, two predictive methods are evaluated and compared. First, it is shown how molecular dynamics simulations (MD) with the umbrella sampling method can be used to calculate free energy profiles in micellar systems. The second applied method is an extension of the COSMO-RS theory to anisotropic systems termed COSMOmic...
May 23, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28533092/thiol-reactive-drug-substrates-of-human-p-glycoprotein-label-the-same-sites-to-activate-atpase-activity-in-membranes-or-dodecyl-maltoside-detergent-micelles
#16
Tip W Loo, David M Clarke
P-glycoprotein (P-gp, ABCB1) is an ABC drug pump that is clinically important because it is involved in multidrug resistance. Many studies have used purified P-gp in detergent (n-dodecyl-β-D-maltoside; DM) micelles to map the locations of the drug-binding sites. A potential problem is that DM could be a substrate and affect binding of drugs to P-gp. To test whether DM was a substrate of P-gp, we used an assay involving drug-rescue of the immature 150 kDa misprocessed P-gp mutant (L1260A) to show that DM is not substrate...
May 19, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28532250/design-and-evaluation-of-mpeg-pla-micelles-functionalized-with-drug-interactive-domains-as-improved-drug-carriers-for-docetaxel-delivery
#17
Dingqing Qi, Feirong Gong, Xin Teng, Mingming Ma, Huijing Wen, Weihao Yuan, Yi Cheng, Chong Lu
Polymeric micelles are very attractive drug delivery systems for hydrophobic agents, owing to their readily tailorable chemical structure and ease for scale-up preparation. However, the intrinsic poor stability of drug-loaded micelles presents one of the major challenges for most micellar systems in the translation to clinical applications. In this study, a simple, well-defined, and easy-to-scale up 9-Fluorenylmethoxycarbonyl (Fmoc) and tert-butoxycarbonyl (Boc) containing lysine dendronized mPEG-PLA (mPEG-PLA-Lys(FB)2) micellar formulation was designed and prepared for docetaxel (DTX) delivery, in an effort to improve the stability of the micelles, and its physicochemical properties, pharmacokinetics, and anti-tumor efficacy against SKOV-3 ovarian cancer were evaluated...
May 22, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28532223/preliminary-study-on-fabrication-characterization-and-synergistic-anti-lung-cancer-effects-of-self-assembled-micelles-of-covalently-conjugated-celastrol-polyethylene-glycol-ginsenoside-rh2
#18
Peng Li, XiaoYue Zhou, Ding Qu, Mengfei Guo, Chenyi Fan, Tong Zhou, Yang Ling
The aim of this study was to develop an amphipathic polyethylene glycol (PEG) derivative that was bi-terminally modified with celastrol and ginsenoside Rh2 (Celastrol-PEG-G Rh2). Such derivative was capable of forming novel, celastrol-loaded polymeric micelles (CG-M) for endo/lysosomal delivery and thereby synergistic treatment of lung cancer. Celastrol-PEG-G Rh2 with a yield of 55.6% was first synthesized and characterized. Its critical micellar concentration was 1 × 10(-5 )M, determined by pyrene entrapment method...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28532112/preparations-and-doxorubicin-controlled-release-of-amino-acid-based-redox-ph-dual-responsive-nanomicelles
#19
Yuanyuan Ding, Liping Zhang, Gang Shi, Xinxin Sang, Caihua Ni
Terpolymers of poly (Lysine-co-N, N-Bis (acryloyl) cystamine-co-β-Phenethylamine) (PLBP) were synthesized in one-pot by Michael addition terpolymerization. The terpolymers self-assembled into nano-sized spherical micelles (84-123nm) with narrow distributions. The surface charge of the nanomicelles (NMs) was depended on solution's pH and showed negative values under physiological conditions (pH7.4), which was beneficial for long circulation without non-specific protein adsorption. Doxorubicin (DOX) was effectively loaded into the NMs for controlled release...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532038/dynamic-covalent-linked-triblock-copolymer-micelles-for-glutathione-mediated-intracellular-drug-delivery
#20
Xueli Wang, Changyu He, Qinglai Yang, Lianjiang Tan, Bingya Liu, Zhenggang Zhu, Bing Gong, Yu-Mei Shen
Redox-responsive linkages dispersed in the backbones of the synthetic polymers, while young in the current spectrum of the biomedical application, are rapidly extending into their niche. In the present work, triblock copolymer PEG-PLA-PEG synthesized and characterized by (1)H -NMR and SEC can self-assemble into redox-responsive micelles in aqueous media with nanosized 33nm and 47nm. And the copolymers PEG2000-PLA3000-PEG2000 and PEG2000-PLA5000-PEG2000 present lower CMC with 0.034 and 0.022mg/mL, and higher DLC of 4...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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