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https://www.readbyqxmd.com/read/28213149/high-electrocapacitive-performance-of-bowl-like-monodispersed-porous-carbon-nanoparticles-prepared-with-an-interfacial-self-assembly-process
#1
Shuxia Zhang, Qiang Weng, Fengqi Zhao, Hongxu Gao, Pei Chen, Xinbing Chen, Zhongwei An
Bowl-like monodispersed porous carbon nanoparticles (BMPCNs) have been successfully prepared with a facile and scalable approach, and the as-prepared BMPCNs are examined thoroughly by various physical characterizations. Physical measurements display that BMPCNs have the high surface area (1255m(2)g(-1)), hierarchical porosity, a certain amount of oxygen-containing groups and high graphitization degree. These unique structure features endow BMPCNs with a high capacitance (281Fg(-1) at 0.5Ag(-1)), excellent rate capability (209Fg(-1) at 50Ag(-1)), and outstanding cycling stability (94...
October 27, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28212490/vitamin-e-succinate-grafted-chitosan-oligosaccharide-rgd-conjugated-tpgs-mixed-micelles-loaded-with-paclitaxel-for-u87mg-tumor-therapy
#2
Yanzuo Chen, Shu Feng, Wenchao Liu, Zeting Yuan, Peihao Yin, Feng Gao
The poor therapeutic efficacy of hydrophobic chemotherapeutic drugs is an intrinsic limitation to successful chemotherapy. In the present study, a multi-task delivery system based on arginine-glycine-aspartic acid peptide (RGD) decorated vitamin E succinate (VES)-grafted-chitosan oligosaccharide (CSO)/RGD-conjugated D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS-RGD) mixed micelles (VeC/T-RGD MM) was first prepared for targeted delivery of paclitaxel (PTX), a hydrophobic anticancer drug, to improve the efficacy of U87MG tumor therapy...
February 17, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28212345/efficient-catalytic-oxidation-of-3-arylthio-and-3-cyclohexylthio-lapachone-derivatives-to-new-sulfonyl-derivatives-and-evaluation-of-their-antibacterial-activities
#3
Mariana F do C Cardoso, Ana T P C Gomes, Caroline Dos S Moreira, Mário M Q Simões, Maria G P M S Neves, David R da Rocha, Fernando de C da Silva, Catarina Moreirinha, Adelaide Almeida, Vitor F Ferreira, José A S Cavaleiro
New sulfonyl-lapachones were efficiently obtained through the catalytic oxidation of arylthio- and cyclohexylthio-lapachone derivatives with hydrogen peroxide in the presence of a Mn(III) porphyrin complex. The antibacterial activities of the non-oxidized and oxidized lapachone derivatives against the Gram-negative bacteria Escherichia coli and the Gram-positive bacteria Staphylococcus aureus were evaluated after their incorporation into polyvinylpyrrolidone (PVP) micelles. The obtained results show that the PVP-formulations of the lapachones 4b-g and of the sulfonyl-lapachones 7e and 7g reduced the growth of S...
February 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28211226/supramolecularly-engineered-amphiphilic-macromolecules-molecular-interaction-overrules-packing-parameters
#4
Prithankar Pramanik, Debes Ray, Vinod K Aswal, Suhrit Ghosh
We report molecular interaction-driven self-assembly of supramolecularly engineered amphiphilic macromolecules (SEAM) containing a single supramolecular structure-directing unit (SSDU) consisting of an H-bonding group connected to a naphthalene diimide chromophore. Two such SEAMs, P1-50 and P2-50, having the identical chemical structure and hydrophobic/hydrophilic balance, exhibit distinct self-assembled structures (polymersome and cylindrical micelle, respectively) due to a difference in the H-bonding group (hydrazide or amide, respectively) of the single SSDU...
February 17, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28209540/in-vitro-characterization-of-ph-sensitive-azithromycin-loaded-methoxy-poly-ethylene-glycol-block-poly-aspartic-acid-graft-imidazole-micelles
#5
Fangfang Teng, Peizong Deng, Zhimei Song, Feilong Zhou, Runliang Feng, Na Liu
In order to improve azithromycin's antibacterial activity in acidic medium, monomethoxy poly (ethylene glycol)-block-poly (aspartic acid-graft-imidazole) copolymer was synthesized through allylation, free radical addition, ring-opening polymerization and amidation reactions with methoxy poly (ethylene glycol) as raw material. Drug loading capacity and encapsulation efficiency of azithromycin-loaded micelles prepared via thin film hydration method were 11.58±0.86% and 96.06±1.93%, respectively. The drug-loaded micelles showed pH-dependent property in the respects of particle size, zeta potential at the range of pH 5...
February 9, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28208061/dual-drug-release-from-hydrogels-covalently-containing-polymeric-micelles-that-possess-different-drug-release-properties
#6
Mari Murata, Yusuke Uchida, Taku Takami, Tomoki Ito, Ryosuke Anzai, Seiichi Sonotaki, Yoshihiko Murakami
In the present study, we designed hydrogels for dual drug release: the hydrogels that covalently contained the polymeric micelles that possess different drug release properties. The hydrogels that were formed from polymeric micelles possessing a tightly packed (i.e., well-entangled) inner core exhibited a higher storage modulus than the hydrogels that were formed from the polymeric micelles possessing a loosely packed structure. Furthermore, we conducted release experiments and fluorescent observations to evaluate the profiles depicting the release of two compounds, rhodamine B and auramine O, from either polymeric micelles or hydrogels...
February 9, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28207270/intracellular-delivery-colloidally-stable-core-crosslinked-triblock-copolymer-micelles-with-glutathione-responsive-enhanced-drug-release-for-cancer-therapy
#7
Jung Kwon Oh, Depannita Biswas, So Young An, Yijing Li, Xiangtao Wang
Design and development of amphiphilic block copolymer-based nanocarriers exhibiting enhanced colloidal stability upon dilution in the blood and cellular glutathione-responsive rapid drug release is highly desired for tumor-targeting chemotherapy. Herein, we report a novel ABA-type triblock copolymer consisting of a hydrophilic central poly(ethylene glycol) block and two terminal hydrophobic blocks of a polymethacrylate having pendant disulfides (PHMssEt), thus PHMssEt-b-PEG-b-PHMssEt (ssTP). Aqueous self-assembly and following disulfide-exchange reaction of the resulting ssTP allows for formation of core-crosslinked micelles (CCMs) through the formation of new disulfide linkages, retaining enhanced colloidal stability in physiological condition and in the presence of proteins...
February 16, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28207251/cross-linked-micellar-spherical-nucleic-acids-from-thermoresponsive-templates
#8
Resham J Banga, Brian Meckes, Suguna P Narayan, Anthony J Sprangers, SonBinh T Nguyen, Chad A Mirkin
A one-pot synthesis of micellar spherical nucleic acid (SNA) nanostructures using Pluronic F127 as a thermoresponsive template is reported. These novel constructs are synthesized in a chemically straightforward process that involves intercalation of the lipid tails of DNA amphiphiles (CpG motifs for TLR-9 stimulation) into the hydrophobic regions of Pluronic F127 micelles followed by chemical cross-linking and subsequent removal of non-crosslinked structures. The dense nucleic acid shell of the resulting cross-linked micellar SNA enhances their stability in physiological media and facilitates their rapid cellular internalization making them effective TLR-9 immunomodulatory agents...
February 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28205290/development-and-qualification-of-an-lc-ms-ms-method-for-investigating-the-biological-implications-of-micelle-entrapped-paclitaxel-in-cell-culture-and-rats
#9
Amal Kaddoumi, Kanwaldeep K Gill, Khaled Elfakhri, Sami Nazzal
Paclitaxel is a front-line antineoplastic drug used in chemotherapeutic modalities for treatment of various types of malignancies. However, its efficacy is limited by dose related toxicities. In this study, we have explored two important biological aspects of entrapping paclitaxel in PEG2000 -DSPE micelles. First, we evaluated the impact of this micellar delivery system on P-glycoprotein (P-gp)-paclitaxel interaction, and we investigated differences in plasma pharmacokinetics of free and micelle entrapped paclitaxel...
February 15, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28205003/antifungal-efficacy-of-an-intravenous-formulation-containing-monomeric-amphotericin-b-5-fluorocytosine-and-saline-for-sodium-supplementation
#10
Celeste Alvarez, David R Andes, Jeong Yeon Kang, Carmen Krug, Glen S Kwon
PURPOSE: Amphotericin B (AmB) and 5-fluorocytosine (5-FC) exhibit additive to synergistic activity against systemic mycoses. Incompatibility of prescribed formulations precludes concomitant IV administration, a route with distinct advantages. Previously, we used PEG-DSPE micelles to produce a reformulation of Fungizone (AmB-SD), AmB solubilized by sodium deoxycholate, called mAmB-90. Herein, we describe a second reformulation that facilitates co-delivery of mAmB-90 and 5-FC, and evaluate the effect of PEG-DSPE micelles on the combination's activity against Candida albicans...
February 15, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28203228/encapsulation-of-antifungals-in-micelles-protects-candida-albicans-during-gall-bladder-infection
#11
Shih-Hung Hsieh, Sascha Brunke, Matthias Brock
Candida albicans is a dimorphic fungus that colonizes human mucosal surfaces with the potential to cause life-threatening invasive candidiasis. Studies on systemic candidiasis in a murine infection model using in vivo real-time bioluminescence imaging revealed persistence of C. albicans in the gall bladder under antifungal therapy. Preliminary analyses showed that bile conferred resistance against a wide variety of antifungals enabling survival in this cryptic host niche. Here, bile and its components were studied for their ability to reduce antifungal efficacy in order to elucidate the underlying mechanism of protection...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28202545/the-basis-for-acyl-specificity-in-the-tafazzin-reaction
#12
Michael Schlame, Yang Xu, Mindong Ren
Tafazzin is a mitochondrial enzyme that transfers fatty acids from phospholipids to lysophospholipids. Mutations in tafazzin cause abnormal molecular species of cardiolipin and the clinical phenotype of Barth syndrome. However, the mechanism by which tafazzin creates acyl specificity has been controversial. We have shown that the lipid phase state can produce acyl specificity in the tafazzin reaction but others have reported that tafazzin itself carries enzymatic specificity. To resolve this issue, we replicated and expanded the controversial experiments, i...
February 15, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28199856/predicting-solubilisation-features-of-ternary-phase-diagrams-of-fully-dilutable-lecithin-linker-microemulsions
#13
Mehdi Nouraei, Edgar J Acosta
Fully dilutable microemulsions (μEs), used to design self-microemulsifying delivery system (SMEDS), are formulated as concentrate solutions containing oil and surfactants, without water. As water is added to dilute these systems, various μEs are produced (water-swollen reverse micelles, bicontinuous systems, and oil-swollen micelles), without the onset of phase separation. Currently, the formulation dilutable μEs follows a trial and error approach that has had a limited success. The objective of this work is to introduce the use of the hydrophilic-lipophilic-difference (HLD) and net-average-curvature (NAC) frameworks to predict the solubilisation features of ternary phase diagrams of lecithin-linker μEs and the use of these predictions to guide the formulation of dilutable μEs...
February 1, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28199114/curcumin-loaded-blood-stable-polymeric-micelles-for-enhancing-therapeutic-effect-on-erythroleukemia
#14
Feirong Gong, Dan Chen, Xin Teng, Junhua Ge, Xianfeng Ning, Ya-Ling Shen, Jian Li, Shanfeng Wang
Curcumin has high potential in suppressing many types of cancer and overcoming multi-drug resistance in a multi-faceted manner by targeting diverse molecular targets. However, the rather low systemic bioavailability resulted from its extremely low aqueous solubility and rapid metabolism and excretion in vivo has hampered its application in cancer therapy. With the primary aim to increase the aqueous solubility of curcumin while retaining its stability in the blood circulation before it accesses the tumor site, here we report preparation of curcumin-loaded N-(tert-butoxycarbonyl)-L-phenylalanine end-capped methoxy-poly(ethylene glycol)-block-poly(ε-caprolactone) (mPEG-PCL-Phe(Boc)) micelles with high stability both in vitro and in vivo and anti-tumor efficacy...
February 15, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28199066/crosslinked-redox-responsive-micelles-based-on-lipoic-acid-derived-amphiphiles-for-enhanced-sirna-delivery
#15
Ariane Tschiche, Bala N S Thota, Falko Neumann, Andreas Schäfer, Nan Ma, Rainer Haag
No abstract text is available yet for this article.
February 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28198632/engineering-oral-and-parenteral-amorphous-amphotericin-b-formulations-against-experimental-trypanosoma-cruzi-infections
#16
Miriam Rolón, Dolores R Serrano, Aikaterini Lalatsa, Esther de Pablo, Juan Jose Torrado, Maria Paloma Ballesteros, Anne Marie Healy, Celeste Vega, Cathia Coronel, Francisco Bolas-Fernández, Maria Auxiliadora Dea-Ayuela
Chagas disease (CD) is a parasitic zoonosis endemic in most mainland countries of Central and South America affecting nearly 10 million people, with 100 million people at high risk of contracting the disease. Treatment is only effective if received at the early stages of the disease. Only two drugs (benznidazole and nifurtimox) have so far been marketed and both share various limitations such as variable efficacy, many side effects and long duration of treatment, thus reducing compliance. The in vitro and in vivo efficacy of poly-aggregated amphotericin B (AmB), encapsulated poly-aggregated AmB in albumin microspheres (AmB-AME) and dimeric AmB - sodium deoxycholate micelles (AmB-NaDC) was evaluated...
February 15, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28198606/sustained-release-of-brimonidine-from-a-new-composite-drug-delivery-system-for-treatment-of-glaucoma
#17
Jianguo Sun, Yuan Lei, Zhaoxing Dai, Xi Liu, Taomin Huang, Jihong Wu, Zhi Ping Xu, Xinghuai Sun
A novel layered double hydroxide (LDH) nanoparticle/thermogel composite drug delivery system (DDS) for sustained release of brimonidine (Bri) has been designed, prepared and characterized in this study for treatment of severe glaucoma. Brimonidine is first loaded onto LDH (Bri@LDH) nanoparticles, which are then dispersed in the thermogel consisting of plenty of micelles based on poly-(DL-lactic acid co-glycolic acid)-polyethylene glycol-poly-(DL-lactic acid co-glycolic acid) (PLGA-PEG-PLGA) copolymer. The Bri@LDH/Thermogel DDS containing 125...
February 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28198489/negative-effects-of-divalent-mineral-cations-on-the-bioaccessibility-of-carotenoids-from-plant-food-matrices-and-related-physical-properties-of-gastro-intestinal-fluids
#18
Joana Corte-Real, Marie Bertucci, Christos Soukoulis, Charles Desmarchelier, Patrick Borel, Elke Richling, Lucien Hoffmann, Torsten Bohn
Carotenoid intake and tissue levels have been frequently associated with reduced risk of chronic diseases. However, their bioavailability is low and influenced by many dietary related parameters. Divalent mineral cations have been suggested to interfere with carotenoid digestion and to hamper micellarization, a prerequisite for their uptake, via complexation of bile salts and precipitation of fatty acids. In the present investigation, we have evaluated the effects of increasing concentrations of magnesium (0-300 mg L(-1)), calcium (0-1500 mg L(-1)), zinc (0-200 mg L(-1)), and sodium (0-1500 mg L(-1); control monovalent cation), on carotenoid bioaccessibility from frequently consumed food items rich in carotenoids (tomato juice, carrot juice, apricot nectar, spinach and field salad), following simulated gastro-intestinal digestion...
February 15, 2017: Food & Function
https://www.readbyqxmd.com/read/28197613/unusual-nanosized-associates-of-carboxy-calix-4-resorcinarene-and-cetylpyridinium-chloride-the-macrocycle-as-a-glue-for-surfactant-micelles
#19
Ju E Morozova, V V Syakaev, Ya V Shalaeva, A M Ermakova, I R Nizameev, M K Kadirov, A D Voloshina, V V Zobov, I S Antipin, A I Konovalov
The association of cetylpyridinium chloride (CPC) micelles in the presence of octaacetated tetraphenyleneoxymethylcalix[4]resorcinarene (CR) leads to the formation of unusual spherical supramolecular nanoparticles (SNPs). Within the range of CR/CPC molar ratios from 10/1 to 1/10 (except for 1/8), CR, acting as a counterion, decreases the critical micelle concentration of CPC by one order of magnitude and leads to the formation of SNPs with an average hydrodynamic radius of 164 nm and an average zeta potential of -60 mV...
February 15, 2017: Soft Matter
https://www.readbyqxmd.com/read/28197581/effect-of-crystallite-size-on-the-performance-and-phase-transformation-of-co3o4-al2o3-catalysts-during-co-prox-an-in-situ-study
#20
Thulani M Nyathi, Nico Fischer, Andy P E York, Michael Claeys
The preferential oxidation of carbon monoxide has been identified as an effective route to remove trace amounts of CO (approx. 0.5-1.0 vol%) in the H2-rich reformate gas stream after the low-temperature water-gas shift. Instead of noble metal-based catalysts, Co3O4-based catalysts were investigated in this study as cheaper and more readily available alternatives. This study aimed at investigating the effect of crystallite size on the mass- and surface area-specific CO oxidation activity as well as on the reduction behaviour of Co3O4...
February 15, 2017: Faraday Discussions
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