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https://www.readbyqxmd.com/read/27933041/production-characterization-and-application-of-bacillus-licheniformis-w16-biosurfactant-in-enhancing-oil-recovery
#1
Sanket J Joshi, Yahya M Al-Wahaibi, Saif N Al-Bahry, Abdulkadir E Elshafie, Ali S Al-Bemani, Asma Al-Bahri, Musallam S Al-Mandhari
The biosurfactant production by Bacillus licheniformis W16 and evaluation of biosurfactant based enhanced oil recovery (EOR) using core-flood under reservoir conditions were investigated. Previously reported nine different production media were screened for biosurfactant production, and two were further optimized with different carbon sources (glucose, sucrose, starch, cane molasses, or date molasses), as well as the strain was screened for biosurfactant production during the growth in different media. The biosurfactant reduced the surface tension and interfacial tension to 24...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27932881/preparation-and-antitumor-evaluation-of-self-assembling-oleanolic-acid-loaded-pluronic-p105-d-%C3%AE-tocopheryl-polyethylene-glycol-succinate-mixed-micelles-for-non-small-cell-lung-cancer-treatment
#2
Hao Wu, Qingxiang Zhong, Rongling Zhong, Houcai Huang, Zhi Xia, Zhongcheng Ke, Zhenhai Zhang, Jie Song, Xiaobin Jia
Oleanolic acid (OA) is a triterpenoid found in various fruits and vegetables and used in traditional Chinese medicine. OA plays a crucial role in the treatment of several cancers, but poor water solubility, low permeability, and significant efflux have limited its widespread clinical use. Vitamin E-d-α-tocopheryl polyethylene glycol succinate (vitamin E-TPGS) and Pluronic P105 were used to improve the solubility and permeability and to decrease the efflux of OA. OA-loaded mixed micelles were prepared by ethanol thin-film hydration...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27932879/study-of-a-new-bone-targeting-titanium-implant-bone-interface
#3
Xiangning Liu, Ye Zhang, Shaobing Li, Yayu Wang, Ting Sun, Zejian Li, Lizhao Cai, Xiaogang Wang, Lei Zhou, Renfa Lai
New strategies involving bone-targeting titanium (Ti) implant-bone interface are required to enhance bone regeneration and osseointegration for orthopedic and dental implants, especially in osteoporotic subjects. In this study, a new dual-controlled, local, bone-targeting delivery system was successfully constructed by loading tetracycline-grafted simvastatin (SV)-loaded polymeric micelles in titania nanotube (TNT) arrays, and a bone-targeting Ti implant-bone interface was also successfully constructed by implanting the delivery system in vivo...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27930982/targeted-osteosarcoma-chemotherapy-using-rgd-peptide-installed-doxorubicin-loaded-biodegradable-polymeric-micelle
#4
Zhenhua Fang, Yanpeng Sun, Hong Xiao, Peng Li, Ming Liu, Fan Ding, Wusheng Kan, Runsheng Miao
Osteosarcoma is the most common primary malignant bone tumor in the pediatric age group, and chemotherapy directed by targeted nanoparticulate drug delivery system represents a promising approach for osteosarcoma treatment recently. Here, we designed and developed a novel DOX-loaded targeted polymeric micelle self-assembled from RGD-terminated poly(ethylene glycol)-block-poly (trimethylene carbonate) (RGD-PEG-PTMC) amphiphilic biodegradable block copolymer, for high-efficiency targeted chemotherapy of osteosarcoma...
December 5, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27930722/dodecylphosphocholine-micelles-induce-amyloid-formation-of-the-prp-110-136-peptide-via-an-%C3%AE-helical-metastable-conformation
#5
Simon Sauvé, Yves Aubin
A peptide encompassing the conserved hydrophobic region and the first β-strand of the prion protein (PrP(110-136)) shown to interact with the surface of dodecylphosphocholine micelles adopts an α-helical conformation that is localized below the head-group layer. This surface-bound peptide has a half-life of one day, and readily initiates the formation of amyloid fibrils. The presence of the latter was confirmed using birefringence microscopy upon Congo red binding and thioflavin T-binding induced fluorescence...
2016: PloS One
https://www.readbyqxmd.com/read/27929164/the-role-of-the-binding-salt-sodium-salicylate-in-semidilute-ionic-cetylpyridinium-chloride-micellar-solutions-a-rheological-and-scattering-study
#6
D Gaudino, R Pasquino, J Stellbrink, N Szekely, M Krutyeva, A Radulescu, W Pyckhout-Hintzen, N Grizzuti
The micellar system based on cetylpyridinium chloride (CPyCl) and sodium salicylate (NaSal) in brine solution is investigated on both macro- and micro-length scales through rheology and scattering measurements. The linear viscoelasticity of the system and its structural parameters are explored by systematically changing the amount of NaSal over an extremely wide range of concentrations, thus producing salt-to-surfactant molar ratios from zero to about 8.5. As a result, the well-known non-monotonic behaviour of the zero-shear rate viscosity as a function of salinity can be connected to micellar morphological changes, whose driving force is represented by the simultaneous binding and screening actions of NaSal...
December 8, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27929153/local-environment-inside-a-novel-aromatic-micelle-investigated-by-steady-state-and-femtosecond-fluorescence-spectroscopy-of-an-encapsulated-solvatochromic-probe
#7
Matthew M Sartin, Kei Kondo, Michito Yoshizawa, Satoshi Takeuchi, Tahei Tahara
The local environment within a recently developed anthracene-shelled micelle (ASM), which is a micelle-like nanocapsule composed of anthracene-embedded amphiphiles, was investigated by steady-state and time-resolved spectroscopy of an encapsulated solvatochromic fluorescent probe molecule, coumarin 153 (C153). The absorption maximum of encapsulated C153 (452 nm) is more red-shifted than that of free C153 in water, indicating a highly polar environment inside the micelle. Despite this, the fluorescence Stokes shift of encapsulated C153 (∼3700 cm(-1)) is substantially smaller than that of free C153 in water...
December 8, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27928121/resistant-maltodextrin-decreases-micellar-solubility-of-lipids-and-diffusion-of-bile-salt-micelles-and-suppresses-incorporation-of-micellar-fatty-acids-into-caco-2-cells
#8
Ikuo Ikeda, Kyouhei Tamakuni, Tomomi Sakuma, Ran Ozawa, Nao Inoue, Yuka Kishimoto
Several studies have suggested that resistant maltodextrin (RMD) suppresses intestinal lipid absorption in experimental animals and humans. However, possible mechanisms underlying this effect are not known. In this study, effects of RMD on processes of the absorption of various lipids were investigated in vitro. RMD dose-dependently suppressed the solubility of various lipid components, including 1-mono-oleoylglycerol, oleic acid, and phosphatidylcholine in bile salt micelles in vitro. When the diffusion rate of bile salt micelles through a filter membrane was investigated in vitro, bile salt micelles containing RMD diffused more slowly than those without RMD...
2016: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/27928119/hypolipidemic-effect-of-the-autoclaved-extract-prepared-from-pea-pisum-sativum-l-pods-in-vivo-and-in-vitro
#9
Kae Inagaki, Yuuki Nishimura, Emiko Iwata, Sachinobu Manabe, Masahiro Goto, Yoshio Ogura, Hisako Hotta
By autoclaving, we obtained a polyphenol and dietary fiber from pea (Pisum sativum L.) pods in parallel without acid or alkali treatment or organic solvent extraction. Rats fed a high-sucrose (HS) diet containing 3% autoclaved extract (AE) for 4 wk exhibited significantly lower serum triglyceride and total cholesterol levels than rats fed a HS diet. AE and soluble dietary fiber (SDF) from AE exhibited pancreatic lipase inhibitory activity at 13.3 mg/mL in vitro. AE and insoluble dietary fiber (IDF) from AE adsorbed cholesterol...
2016: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/27926514/novel-amphiphilic-folic-acid-cholesterol-chitosan-micelles-for-paclitaxel-delivery
#10
Li-Chun Cheng, Yan Jiang, Yu Xie, Lu-Lu Qiu, Qing Yang, Hui-Yi Lu
In order to decrease the toxicity of paclitaxel (PTX) and increase the efficiency, we developed an amphiphilic PTX injection system using a biodegradable and biocompatible polymer synthesized by folic acid, cholesterol, and chitosan (FACC). This FACC-based polymer had a low critical concentration (64.13μg/ml) and could self-assemble in aqueous condition to form nanoscale micelles. The particle sizes of FACC-PTX micelles were 253.2±0.56 nm, the encapsulation efficiency and loading capacity of these FACC-PTX micelles were 65...
December 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27924929/fast-interfacial-charge-transfer-in-%C3%AE-fe2o3-%C3%AE-c%C3%AE-fevo4-x-%C3%AE-cx-%C3%AE-c-bulk-heterojunctions-with-controllable-phase-content
#11
Chengcheng Zhao, Guoqiang Tan, Wei Yang, Chi Xu, Ting Liu, Yuning Su, Huijun Ren, Ao Xia
The novelties in this paper are embodied in the fast interfacial charge transfer in α-Fe2O3-δCδ/FeVO4-x+δCx-δ@C bulk heterojunctions with controllable phase compositions. The carbon source-glucose plays an important role as the connecting bridge between the micelles in the solution, forming interfacial C-O, C-O-Fe and O-Fe-C bonds through dehydration and polymerization reactions. Then the extra VO3(-) around the FeVO4 colloidal particles can react with unstable Fe(OH)3, resulting the phase transformation from α-Fe2O3 (47...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27924310/tunable-oleo-furan-surfactants-by-acylation-of-renewable-furans
#12
Dae Sung Park, Kristeen E Joseph, Maura Koehle, Christoph Krumm, Limin Ren, Jonathan N Damen, Meera H Shete, Han Seung Lee, Xiaobing Zuo, Byeongdu Lee, Wei Fan, Dionisios G Vlachos, Raul F Lobo, Michael Tsapatsis, Paul J Dauenhauer
An important advance in fluid surface control was the amphiphilic surfactant composed of coupled molecular structures (i.e., hydrophilic and hydrophobic) to reduce surface tension between two distinct fluid phases. However, implementation of simple surfactants has been hindered by the broad range of applications in water containing alkaline earth metals (i.e., hard water), which disrupt surfactant function and require extensive use of undesirable and expensive chelating additives. Here we show that sugar-derived furans can be linked with triglyceride-derived fatty acid chains via Friedel-Crafts acylation within single layer (SPP) zeolite catalysts...
November 23, 2016: ACS Central Science
https://www.readbyqxmd.com/read/27924155/versatile-ph-response-micelles-with-high-cell-penetrating-helical-diblock-copolymers-for-photoacoustic-imaging-guided-synergistic-chemo-photothermal-therapy
#13
Shengyu Shi, Yajing Liu, Yu Chen, Zhihuang Zhang, Yunsheng Ding, Zongquan Wu, Jun Yin, Liming Nie
With high optical absorption efficiency, near infrared (NIR) dyes have been proposed as theranostic agents for fluorescence imaging, photoacoustic imaging (PAI), and photothermal therapy (PTT). However, inherent hydrophobicity and short circulation time of small molecule hinder the further biomedical application. Herein smart amphiphilic copolymer was synthesized containing IR780/camptothecin@poly(ε-caprolactone) (IR780/CPT@PCL) as core, helical poly(phenyl isocyanide) (PPI) blocks as shell with the pH-responsive rhodamine B (RhB) moieties in the core-shell interface...
2016: Theranostics
https://www.readbyqxmd.com/read/27923139/plga-peg-plga-triblock-copolymeric-micelles-as-oral-drug-delivery-system-in-vitro-drug-release-and-in-vivo-pharmacokinetics-assessment
#14
Xiufen Chen, Jianzhong Chen, Bowen Li, Xiang Yang, Rongjie Zeng, Yajun Liu, Tao Li, Rodney J Y Ho, Jingwei Shao
Poly (d,l-lactide-co-glycolide)-poly (ethylene glycol)-poly (d,l-lactide-co-glycolide) triblock copolymers (PLGA-PEG-PLGA) has been proven to be desirable for anti-cancer drug delivery by intravenous administration. But till now there is no report of developing this micelle as a sustained oral formulation for cancer therapy. 3β-acetoxy-urs-12-en-28-oic acid hexamethylenediamine (US597), a derivative of natural product ursolic acid has been developed as a novel cancer metastasis chemopreventive agent by us...
November 26, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27921280/ph-responsive-triblock-copolymeric-micelles-decorated-with-a-cell-penetrating-peptide-provide-efficient-doxorubicin-delivery
#15
Khen Eng Ng, Mohd Cairul Iqbal Mohd Amin, Haliza Katas, Muhammad Wahab Amjad, Adeel Masood Butt, Prashant Kesharwani, Arun K Iyer
This study developed novel triblock pH-responsive polymeric micelles (PMs) using cholic acid-polyethyleneimine-poly-L-arginine (CA-PEI-pArg) copolymers. PEI provided pH sensitivity, while the hydrophilic cell-penetrating pArg peptide promoted cellular PM internalization. The copolymers self-assembled into PMs in aqueous solution at above the critical micelle concentration (2.98 × 10(-7) M) and encapsulated doxorubicin in the core region, with a 34.2% (w/w) entrapment efficiency. PMs showed pH-dependent swelling, increasing in size by almost sevenfold from pH 7...
December 2016: Nanoscale Research Letters
https://www.readbyqxmd.com/read/27921107/hollow-carbon-nanospheres-using-an-asymmetric-triblock-copolymer-structure-directing-agent
#16
Yunqi Li, Haibo Tan, Rahul R Salunkhe, Jing Tang, Lok Kumar Shrestha, Bishnu Prasad Bastakoti, Hongpan Rong, Toshiaki Takei, Joel Henzie, Yusuke Yamauchi, Katsuhiko Ariga
We introduce a simple method to prepare hollow carbon nanospheres (HCNs) by using triblock copolymer poly(styrene-b-2-vinylpyridine-b-ethylene oxide) (PS-b-P2VP-b-PEO) micelles as a new class of soft-templates. Simply by changing the solvent we can prepare ultra-small sized micelles of the triblock copolymer PS-b-P2VP-b-PEO soft template to obtain HCNs with ultra-small diameters (43 nm) and hollow cores (19 nm). Furthermore, we use these HCNs to make electric double-layer capacitors (EDLCs) that exhibit superior performance...
December 6, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27919818/plga-soya-lecithin-based-micelles-for-enhanced-delivery-of-methotrexate-cellular-uptake-cytotoxic-and-pharmacokinetic-evidences
#17
Anupama Singh, Nagarani Thotakura, Rajendra Kumar, Bhupinder Singh, Gajanand Sharma, Om Prakash Katare, Kaisar Raza
Biocompatible and biodegradable polymers like PLGA have revolutionized the drug delivery approaches. However, poor drug loading and substantially high lipophilicity, pave a path for further tailing of this promising agent. In this regard, PLGA was feathered with biocompatible phospholipid and polymeric micelles were developed for delivery of Methotrexate (MTX) to cancer cells. The nanocarriers (114.6nm±5.5nm) enhanced the cytotoxicity of MTX by 2.13 folds on MDA-MB-231 cells. Confocal laser scanning microscopy confirmed the increased intracellular delivery...
December 2, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27918989/ph-responsive-polymeric-micelles-based-on-poly-ethyleneglycol-b-poly-2-diisopropylamino-ethyl-methacrylate-block-copolymer-for-enhanced-intracellular-release-of-anticancer-drugs
#18
Zhigang Xu, Peng Xue, Yong-E Gao, Shiying Liu, Xiaoxiao Shi, Meili Hou, Yuejun Kang
We present a pH-responsive poly(ethyleneglycol)-b-poly(2-(diisopropylamino) ethyl methacrylate) block copolymer (MPEG-PPDA) that can self-assemble into micelles at very low critical micelle concentration. The formed micelles exhibit superior stability in physiological environment and pH-triggered transforming capability between self-assembly and disassembly. Moreover, the resulting micelles can load hydrophobic anticancer drug molecules such as doxorubicin in the core of micelles. The pH-triggered drug release kinetics matches the classical hydrazone bond model...
November 27, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27918967/nanoencapsulation-an-efficient-and-promising-approach-to-maximize-wound-healing-efficacy-of-curcumin-a-review-of-new-trends-and-state-of-the-art
#19
REVIEW
Zahid Hussain, Hnin Ei Thu, Shiow-Fern Ng, Shahzeb Khan, Haliza Katas
Wound healing is a multifarious and vibrant process of replacing devitalized and damaged cellular structures, leading to restoration of the skin's barrier function, re-establishment of tissue integrity, and maintenance of the internal homeostasis. Curcumin (CUR) and its analogs have gained widespread recognition due to their remarkable anti-inflammatory, anti-infective, anticancer, immunomodulatory, antioxidant, and wound healing activities. However, their pharmaceutical significance is limited due to inherent hydrophobic nature, poor water solubility, low bioavailability, chemical instability, rapid metabolism and short half-life...
November 30, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27918445/docetaxel-loaded-self-assembly-stearic-acid-modified-bletilla-striata-polysaccharide-micelles-and-their-anticancer-effect-preparation-characterization-cellular-uptake-and-in-vitro-evaluation
#20
Qingxiang Guan, Dandan Sun, Guangyuan Zhang, Cheng Sun, Miao Wang, Danyang Ji, Wei Yang
Poorly soluble drugs have low bioavailability after oral administration, thereby hindering effective drug delivery. A novel drug-delivery system of docetaxel (DTX)-based stearic acid (SA)-modified Bletilla striata polysaccharides (BSPs) copolymers was successfully developed. Particle size, zeta potential, encapsulation efficiency (EE), and loading capacity (LC) were determined. The DTX release percentage in vitro was determined using high performance liquid chromatography (HPLC). The hemolysis and in vitro anticancer activity were studied...
December 2, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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