keyword
MENU ▼
Read by QxMD icon Read
search

micelles

keyword
https://www.readbyqxmd.com/read/29150729/effect-of-microemulsion-structure-on-fluorescence-and-nonlinear-optical-properties-of-rhodamine-6g
#1
M Pourtabrizi, N Shahtahmassebi, A Kompany, S Sharifi
This study is conducted to investigate the effect of nano-droplets concentration and size on linear and nonlinear optical properties of Rhodamine 6G by UV-Vis, spectrofluorometer and Z-Scan techniques. Nano-droplets were prepared by mixture of AOT, n-Decane and Water at three different water to surfactant molar ratios (W = 3, 6.7 and 40) and two dye to water mass ratios (R). At high enough dye concentration, the fluorescence intensity and its red shift depend on the concentration of dye in water nano-droplets (R)...
November 18, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/29150015/the-flotation-and-adsorption-of-mixed-collectors-on-oxide-and-silicate-minerals
#2
REVIEW
Longhua Xu, Jia Tian, Houqin Wu, Zhongyuan Lu, Wei Sun, Yuehua Hu
The analysis of flotation and adsorption of mixed collectors on oxide and silicate minerals is of great importance for both industrial applications and theoretical research. Over the past years, significant progress has been achieved in understanding the adsorption of single collectors in micelles as well as at interfaces. By contrast, the self-assembly of mixed collectors at liquid/air and solid/liquid interfaces remains a developing area as a result of the complexity of the mixed systems involved and the limited availability of suitable analytical techniques...
November 11, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/29148846/preparation-and-evaluation-of-curcumin-loaded-self-assembled-micelles
#3
Lu-Lu Wang, Dan-Dan He, Shu-Xia Wang, Yun-Hao Dai, Jian-Ming Ju, Cheng-Lei Zhao
Objective Curcumin being used to treat various chronic diseases while its poor bioavailability issue limited its wide clinical application as a therapeutic agent. The aim of this work was to prepare curcumin-loaded self-assembled micelles using soluplus and solutol®HS15 (SSCMs) to enhance curcumin's solubility and thus oral bioavailability. Methods Optimum formulation was investigated and the optimized ratio of drugs and excipients was obtained and the SSCMs were prepared via ethanol solvent evaporation method...
November 17, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29148803/hsdhodh-microdomain-membrane-interactions-are-influenced-by-the-lipid-composition
#4
Eduardo Festozo Vicente, Indra Dev Sahu, Edson Crusca, Luis Guilherme Mansor Basso, Claudia Elisabeth Munte, Antonio Jose Costa-Filho, Gary A Lorigan, Eduardo Maffud Maffud Cilli
Human dihydroorotate dehydrogenase (HsDHODH) enzyme has been studied as selective target for inhibitors to block the enzyme activity, intending to prevent proliferative diseases. The N-terminal microdomain seems to play an important role in the enzyme function. However, the molecular mechanism of action and dynamics of this region are not totally understood yet. This study analyzes the interaction and conformation in model membranes of HsDHODH microdomain using peptide analogues containing the paramagnetic amino acid TOAC at strategic positions...
November 17, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29148735/stereoselective-stabilization-of-polymeric-vitamin-e-conjugate-micelles
#5
Min Gao, Jian Deng, Huiying Chu, Yu Tang, Zheng Wang, Yanjun Zhao, Guohui Li
Vitamin E (α-tocopherol) (TPGS) micelle is a robust nanocarrier in delivering hydrophobic active pharmaceutical ingredients, but is suffering from poor stability that is essential in terms of pharmaceutical and biomedical applications. Taking advantage of the chirality of vitamin E, this work reports the stereoselective stabilization of polymer-vitamin E conjugate micelles. Vitamin E was covalently linked to multivalent methoxy poly(ethylene glycol)-co-poly(glutamic acid), generating amphiphilic conjugates that could self-assemble into micelles...
November 17, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29147525/multi-component-hybrid-hydrogels-understanding-the-extent-of-orthogonal-assembly-and-its-impact-on-controlled-release
#6
Vânia M P Vieira, Laura L Hay, David K Smith
This paper reports self-assembled multi-component hybrid hydrogels including a range of nanoscale systems and characterizes the extent to which each component maintains its own unique functionality, demonstrating that multi-functionality can be achieved by simply mixing carefully-chosen constituents. Specifically, the individual components are: (i) pH-activated low-molecular-weight gelator (LMWG) 1,3;2,4-dibenzylidenesorbitol-4',4''-dicarboxylic acid (DBS-COOH), (ii) thermally-activated polymer gelator (PG) agarose, (iii) anionic biopolymer heparin, and (iv) cationic self-assembled multivalent (SAMul) micelles capable of binding heparin...
October 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29145770/camptothecin-prodrug-nanomicelle-based-on-a-boronate-ester-linked-diblock-copolymer-as-the-carrier-of-doxorubicin-with-enhanced-cellular-uptake
#7
Ya Gao, Yi Xiao, Shiyuan Liu, Jiahui Yu
A novel pH-sensitive polymeric prodrug of camptothecin (CPT) by polymerizing γ-camptothecin-glutamate N-carboxyanhydride (Glu (CPT)-NCA) on boronate ester-linked poly (ethyleneglycol) (PEG) directly via the amine-initiated ring open polymerization (ROP) has been developed. The resulting amphiphilic prodrug (mPEG-BC-PGluCPT) could self-assemble into nanoparticles and encapsulate doxorubicin (Dox) simultaneously in aqueous solution for dual-drug delivery. The formation of polymeric prodrug micelles (mPEG-BC@PGluCPT) was confirmed by the measurements of critical aggregation concentration (CAC), particle size, and morphology observations...
November 17, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29145727/directly-observing-micelle-fusion-and-growth-in-solution-by-liquid-cell-transmission-electron-microscopy
#8
Lucas R Parent, Evangelos Bakalis, Abelardo Ramírez-Hernández, Jacquelin K Kammeyer, Chiwoo Park, Juan de Pablo, Francesco Zerbetto, Joseph P Patterson, Nathan C Gianneschi
Amphiphilic small molecules and polymers form commonplace nanoscale macromolecular compartments and bilayers, and as such are truly essential components in all cells and in many cellular processes. The nature of these architectures, including their formation, phase changes, and stimuli-response behaviors, is necessary for the most basic functions of life, and over the past half-century, these natural micellar structures have inspired a vast diversity of industrial products, from biomedicines to detergents, lubricants, and coatings...
November 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29144761/amphiphiles-without-head-and-tail-design-nanostructures-based-on-the-self-assembly-of-anionic-boron-cluster-compounds
#9
Roberto Fernandez-Alvarez, Vladimír Ďorďovič, Mariusz Uchman, Pavel Matejicek
Anionic boron hydride cluster compounds (ABCCs) are intrinsically amphiphilic building blocks suitable for nanochemistry. ABCCs are involved in atypical weak interactions, notably dihydrogen bonding, due to their peculiar polyhedral structure, consisting of negatively charged B-H units. The most striking feature of ABCCs that differentiates them from typical surfactants is the lack of head-and-tail structure. Furthermore, their structure can be described as intrinsically amphiphilic or aquaneutral. Therefore, classical terms established to describe self-assembly of classical amphiphiles are insufficient and need to be reconsidered...
November 16, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29144603/hyaluronic-acid-based-micelles-as-ocular-platform-to-modulate-the-loading-release-and-corneal-permeation-of-corticosteroids
#10
Flavia Bongiovì, Giulia Di Prima, Fabio S Palumbo, Mariano Licciardi, Giovanna Pitarresi, Gaetano Giammona
The aim of this work is to prepare hyaluronic acid-based micelles as a platform to load corticosteroid drugs and to improve their corneal permeation after administration on the ocular surface. Three amphiphilic derivatives of hyaluronic acid (HA) are synthesized using different amounts of hexadecylamine (C16 -NH2 ). HAC16 a, HAC16 b, and HAC16 c derivatives are able to form micelles by the cosolvent evaporation method and to entrap corticosteroids (dexamethasone, triamcinolone, triamcinolone acetonide). HAC16 a and HAC16 b micelles show the best results in terms of drug loading and particle size...
November 16, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29141366/-in-vitro-early-detection-of-amyloid-plaques-in-alzheimer-s-disease-by-pittsburgh-compound-b-modified-magnetic-nanoparticles
#11
J Q Zeng, J Q Wu, M H Li, P J Wang
Objective: To construct magnetic nanoparticles targeting β-amyloid (Aβ) plaques, the pathological biomarker of Alzheimer's disease (AD) and to study their binding capability in vitro. Methods: Superparamagnetic nanoparticles Mn(0.6)Zn(0.4)Fe(2)O(4) (MZF) were coated with amphiphilic star-block copolymeric micelles and modified with Aβ-specific probe Pittsburgh compound B (PiB) to construct a novel magnetic nanoparticle MZF-PiB, which specifically targeted amyloid plaques. Transmission electron microscope was used to study the morphological features of MZF-PiB...
November 7, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29139528/assembly-of-small-molecule-surfactants-at-highly-dynamic-air-water-interfaces
#12
Omar T Mansour, Beatrice Cattoz, Manon Beaube, Morganne Montagnon, Richard K Heenan, Ralf Schweins, Marie-Sousai Appavou, Peter C Griffiths
Small-angle neutron scattering has been used to probe the interfacial structure of foams stabilised by small molecule surfactants at concentrations well below their critical micelle concentration. The data for wet foams showed a pronounced Q(-4) dependence at low Q and noticeable inflexions over the mid Q range. These features were found to be dependent on the surfactant structure (mainly the alkyl chain length) with various inflexions across the measured Q range as a function of the chain length but independent of factors such as concentration and foam age/height...
November 15, 2017: Soft Matter
https://www.readbyqxmd.com/read/29138561/a-simple-reduction-sensitive-micelles-co-delivery-of-paclitaxel-and-dasatinib-to-overcome-tumor-multidrug-resistance
#13
Jun Li, Ruitong Xu, Xiao Lu, Jing He, Shidai Jin
Multidrug resistance (MDR) is one of the major obstacles in successful chemotherapy. The combination of chemotherapy drugs and multidrug-resistant reversing agents for treating MDR tumor is a good strategy to overcome MDR. In this work, we prepared the simple redox-responsive micelles based on mPEG-SS-C18 as a co-delivery system to load the paclitaxel (PTX) and dasatinib (DAS) for treatment of MCF-7/ADR cells. The co-loaded micelles had a good dispersity and a spherical shape with a uniform size distribution, and they could quickly disassemble and rapidly release drugs under the reduction environment...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29138104/novel-mixed-vesicles-containing-lactobacilli-biosurfactant-for-vaginal-delivery-of-an-anti-candida-agent
#14
Angela Abruzzo, Barbara Giordani, Carola Parolin, Beatrice Vitali, Michele Protti, Laura Mercolini, Martina Cappelletti, Stefano Fedi, Federica Bigucci, Teresa Cerchiara, Barbara Luppi
The purpose of this work was to prepare and characterize an innovative formulation for vaginal delivery of econazole nitrate, commonly used for the treatment of Candida infections. A novel biosurfactant isolated from a vaginal Lactobacillus strain was used to prepare phosphatidylcholine based mixed vesicles. Biosurfactant was produced by Lactobacillus gasseri BC9, isolated from the vagina of a healthy premenopausal woman, and was chemically characterized by FT-IR and ESI-MS. Mixed vesicles, obtained through film rehydration and extrusion method, were characterized in terms of size, zeta potential, encapsulation efficiency, mucoadhesion properties and econazole release...
November 11, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29137992/ir-spectroscopy-analysis-of-pancreatic-lipase-related-protein-2-interaction-with-phospholipids-3-monitoring-dppc-lipolysis-in-mixed-micelles
#15
Eduardo Mateos-Diaz, Priscila Sutto-Ortiz, Moulay Sahaka, Jorge A Rodriguez, Frédéric Carrière
Usual methods for the continuous assay of lipolytic enzyme activities are mainly based on the titration of free fatty acids, surface pressure monitoring or spectrophotometry using substrates labeled with specific probes. These approaches only give a partial information on the chemistry of the lipolysis reaction and additional end-point analyses are often required to quantify both residual substrate and lipolysis products. We used transmission infrared (IR) spectroscopy to monitor simultaneously the hydrolysis of phospholipids by guinea pig pancreatic lipase-related protein 2 (GPLRP2) and the release of lipolysis products...
November 11, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/29137748/a-novel-synthesis-of-a-new-thorium-iv-metal-organic-framework-nanostructure-with-well-controllable-procedure-through-ultrasound-assisted-reverse-micelle-method
#16
Ghasem Sargazi, Daryoush Afzali, Ali Mostafavi
Reverse micelle (RM) and ultrasound assisted reverse micelle (UARM) were applied to the synthesis of novel thorium nanostructures as metal organic frameworks (MOFs). Characterization with different techniques showed that the Th-MOF sample synthesized by UARM method had higher thermal stability (354°C), smaller mean particle size (27nm), and larger surface area (2.02×10(3)m(2)/g). Besides, in this novel approach, the nucleation of crystals was found to carry out in a shorter time. The synthesis parameters of UARM method were designed by 2(k-1) factorial and the process control was systematically studied using analysis of variance (ANOVA) and response surface methodology (RSM)...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29136371/designing-dendron-polymer-conjugate-based-targeted-drug-delivery-platforms-with-a-mix-and-match-modularity
#17
Burcu Sumer Bolu, Bianka Golba, Nazli Boke, Amitav Sanyal, Rana Sanyal
Polymeric micellar systems are emerging as a very important class of nano-pharmaceuticals due to their ability to improve pharmacokinetics and bio-distribution of chemotherapy drugs, as well as to reduce related systemic toxicities. While these nano sized delivery systems inherently benefit from passive targeting through the enhanced permeation and retention effect leading to increased accumulation in the tumor, additional active targeting can be achieved through surface modification of micelles with targeting groups specific for over-expressed receptors of tumor cells...
November 14, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29136298/tuning-the-f%C3%A3-rster-resonance-energy-transfer-through-self-assembly-approach-for-efficient-white-light-emission-in-aqueous-medium
#18
Pragyan Pallavi, Bahadur Sk, Palak Ahir, Abhijit Patra
A simple and cost-effective methodology employing environmentally benign substances for the fabrication of white-light emitting materials is important for practical applications in the field of lighting and display devices. Designing of purely organic-based white-light emitting system with high quantum efficiency in the aqueous medium is an unmet challenge. With this objective, a new class of pyridoindole based hydrophobic fluorophore 6,7,8,9-tetrapropylpyrido[1,2-a]indole-10-carbaldehye (TPIC) was introduced...
November 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29135251/micellar-thrombin-binding-aptamers-reversible-nanoscale-anticoagulants
#19
Alexander Roloff, Andrea S Carlini, Cassandra E Callmann, Nathan C Gianneschi
Aptamers are nucleic acid-based ligands that exhibit promising features including specific and reversible target binding and inhibition. Aptamers can function as anticoagulants if they are directed against enzymes of the coagulation cascade. However, they typically suffer from nucleolytic digestion and fast clearance from the bloodstream. We present thrombin-binding aptamer amphiphiles that self-assemble into nanoscale polymeric micelles with a densely functionalized aptamer-displaying corona. We show that these micellar aptamers retain their native secondary structure in a crowded environment and are stabilized against degradation by nucleases in human serum...
November 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29135217/vitamin-c-conjugated-nanoparticle-protects-cells-from-oxidative-stress-at-low-dose-but-induces-oxidative-stress-and-cell-death-at-high-dose
#20
Atanu Chakraborty, Nikhil R Jana
Although antioxidant property of vitamin C is well known for protecting cells from oxidative stress, recent study shows that it can also generate oxidative stress under high intra-cellular concentration and induce cell death. However, poor chemical stability and low biological concentration (micromolar) of vitamin C restrict their function primarily as antioxidant. Here we report two different nanoparticle forms of vitamin C with its intact chemical stability, glucose responsive release from nanoparticle and efficient cell delivery in micro to millimolar concentration...
November 14, 2017: ACS Applied Materials & Interfaces
keyword
keyword
53400
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"