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Depression and work impairment

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https://www.readbyqxmd.com/read/29923530/a-study-on-prevalence-of-depression-and-associated-risk-factors-among-elderly-in-a-rural-block-of-tamil-nadu
#1
M Buvneshkumar, K R John, M Logaraj
Background: Depression among elderly is an important public health problem responsible for considerable morbidity and disability. Causes of depression are multifactorial and often preventable. As there was dearth of community studies in Tamil Nadu, the present study was undertaken. Objectives: The objective of this study is to estimate the prevalence of depression and to assess the factors which are associated with depression among elderly. Methods: A cross-sectional study was done from July 2014 to July 2015 among elderly in Kattankulathur block with a sample size of 690 by cluster sampling method...
April 2018: Indian Journal of Public Health
https://www.readbyqxmd.com/read/29912316/constitutive-inactivation-of-the-prrt2-gene-alters-short-term-synaptic-plasticity-and-promotes-network-hyperexcitability-in-hippocampal-neurons
#2
Pierluigi Valente, Alessandra Romei, Manuela Fadda, Bruno Sterlini, Davide Lonardoni, Nicola Forte, Floriana Fruscione, Enrico Castroflorio, Caterina Michetti, Giorgia Giansante, Flavia Valtorta, Jin-Wu Tsai, Federico Zara, Thierry Nieus, Anna Corradi, Anna Fassio, Pietro Baldelli, Fabio Benfenati
Mutations in PRoline-Rich Transmembrane protein 2 (PRRT2) underlie a group of paroxysmal disorders including epilepsy, kinesigenic dyskinesia and migraine. Most of the mutations lead to impaired PRRT2 expression and/or function, emphasizing the pathogenic role of the PRRT2 deficiency. In this work, we investigated the phenotype of primary hippocampal neurons obtained from mouse embryos in which the PRRT2 gene was constitutively inactivated. Although PRRT2 is expressed by both excitatory and inhibitory neurons, its deletion decreases the number of excitatory synapses without significantly affecting the number of inhibitory synapses or the nerve terminal ultrastructure...
April 18, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29909810/major-depression-impairs-incentive-processing-evidence-from-the-heart-and-the-face
#3
Jessica Franzen, Kerstin Brinkmann, Guido H E Gendolla, Othman Sentissi
BACKGROUND: The present study tested the hypothesis of a differential pattern of reward and punishment responsiveness in depression measuring effort mobilization during anticipation and facial expressions during consumption. METHODS: Twenty patients with major depressive disorder (MDD) and 20 control participants worked on a memory task under neutral, reward, and punishment instructions. Effort mobilization was operationalized as cardiovascular reactivity, while facial expressions were measured by facial electromyographic reactivity...
June 18, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29908383/cognition-mood-and-quality-of-life-outcomes-among-low-literacy-adults-living-with-epilepsy-in-rural-kenya-a-preliminary-study
#4
Patrick N Mwangala, Symon M Kariuki, Moses K Nyongesa, Paul Mwangi, Esther Chongwo, Charles R Newton, Amina Abubakar
Epilepsy is frequently associated with neurocognitive impairments, mental health, and psychosocial problems but these are rarely documented in low- and middle-income countries. The aim of this study was to examine the neurocognitive outcomes, depressive symptoms, and psychosocial adjustments of people with epilepsy (PWE) in Kilifi, Kenya. We evaluated the impact of these outcomes on health-related quality of life. Self-report, interviewer-administered measures of depression (Major Depression Inventory) and quality of life (RAND SF-36) were administered to 63 PWE and 83 community controls...
June 12, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29904912/duchenne-muscular-dystrophy-and-caregiver-burden-a-systematic-review
#5
REVIEW
Erik Landfeldt, Josefin Edström, Filippo Buccella, Janbernd Kirschner, Hanns Lochmüller
AIM: To conduct a systematic literature review of caregiver burden in Duchenne muscular dystrophy (DMD). METHOD: We searched Embase, Web of Science, and PubMed for full-text articles reporting results from studies of caregiver burden in DMD. RESULTS: We identified 483 unique publications. Of these, 450 were excluded after title and abstract screening, and 12 after full-text review. A total of 21 articles were included for data synthesis. Results encompassing more than 15 aspects of caregiver burden, investigated through surveys and/or interviews across 15 countries, were identified in the literature...
June 14, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29904343/acute-stress-induced-epigenetic-modulations-and-their-potential-protective-role-toward-depression
#6
Francesco Rusconi, Elena Battaglioli
Psychiatric disorders entail maladaptive processes impairing individuals' ability to appropriately interface with environment. Among them, depression is characterized by diverse debilitating symptoms including hopelessness and anhedonia, dramatically impacting the propensity to live a social and active life and seriously affecting working capability. Relevantly, besides genetic predisposition, foremost risk factors are stress-related, such as experiencing chronic psychosocial stress-including bullying, mobbing and abuse-, and undergoing economic crisis or chronic illnesses...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29901032/emotion-recognition-and-its-relation-to-prefrontal-function-and-network-in-heroin-plus-nicotine-dependence-a-pilot-study
#7
Hada Fong-Ha Ieong, Zhen Yuan
Many patients with substance use disorders (SUDs) live in a stressful environment, and comorbidity is not uncommon. Understanding the neural mechanisms underlying heroin and nicotine dependences and their relationships to social cognition could facilitate behavioral therapy efficacy. We aimed to provide a translational approach that leads to identifying potential biomarkers for opioid use disorder (OUD) susceptibility during recovery. We examined the clinical characters and the relationships between theory of mind (ToM) and executive functions in three groups: heroin plus nicotine-dependent (HND) patients who had remained heroin abstinent ( <mml:math xmlns:mml="http://www...
April 2018: Neurophotonics
https://www.readbyqxmd.com/read/29896094/neural-basis-of-the-emotional-conflict-processing-in-major-depression-erps-and-source-localization-analysis-on-the-n450-and-p300-components
#8
Jing Zhu, Jianxiu Li, Xiaowei Li, Juan Rao, Yanrong Hao, Zhijie Ding, Gangping Wang
Objects: Effective psychological function requires that cognition is not affected by task-irrelevant emotional stimuli in emotional conflict. Depression is mainly characterized as an emotional disorder. The object of this study is to reveal the behavioral and electrophysiological signature of emotional conflict processing in major depressive disorder (MDD) using event-related potentials (ERPs) and standardized low-resolution brain electromagnetic tomography (sLORETA) analysis. Method: We used a face-word Stroop task involving emotional faces while recording EEG (electroencephalography) in 20 patients with MDD and 20 healthy controls (HCs)...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29886347/impact-of-group-treatment-for-insomnia-on-daytime-symptomatology-analyses-from-a-randomized-controlled-trial-in-primary-care
#9
Christina Sandlund, Jerker Hetta, Gunnar H Nilsson, Mirjam Ekstedt, Jeanette Westman
BACKGROUND: People typically seek primary health care for daytime symptoms and impairments they experience in association with their insomnia. However, few studies address the question of whether insomnia treatment can improve such symptomatology. OBJECTIVES: To investigate whether a nurse-led group treatment program, based on the techniques of cognitive behavioral therapy for insomnia (CBT-I), improved daytime symptomatology in primary care patients with insomnia...
May 24, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29885664/zumba-induced-takotsubo-cardiomyopathy-a-case-report
#10
Sana Chams, Skye El Sayegh, Mulham Hamdon, Sarwan Kumar, Zain Kulairi
BACKGROUND: Takotsubo cardiomyopathy or stress cardiomyopathy is characterized by transient left ventricular apical ballooning in the absence of coronary occlusion. The underlying pathophysiological mechanism is still unclear but possible causes have been proposed mainly catecholamine cardiotoxicity, followed by metabolic disturbance, coronary microvascular impairment, and multivessel epicardial coronary artery vasospasm. Takotsubo cardiomyopathy accounts for 1-2% of patients presenting with acute coronary syndrome with the majority of patients diagnosed with Takotsubo cardiomyopathy being women > 55 years of age...
June 10, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29885468/antidepressant-like-effect-induced-by-cannabidiol-is-dependent-on-brain-serotonin-levels
#11
Amanda J Sales, Carlos C Crestani, Francisco S Guimarães, Sâmia R L Joca
Cannabidiol (CBD) is a compound of Cannabis sativa with relevant therapeutic potential in several neuropsychiatric disorders including depression. CBD treatment has shown significant antidepressant-like effects in different rodent preclinical models. However, the mechanisms involved in CBD-induced antidepressant effects are still poorly understood. Therefore, this work aimed at investigating the participation of serotonin (5-HT) and/or noradrenaline (NA) in CBD-induced antidepressant-like effects in the forced swimming test (FST) by: 1) testing if CBD co-administration with serotonergic (fluoxetine, FLX) or noradrenergic (desipramine, DES) antidepressants would have synergistic effects; and 2) investigating if 5-HT or NA depletion would impair CBD-induced behavioral effects...
June 6, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29879231/the-association-of-fatigue-pain-depression-and-anxiety-with-work-and-activity-impairment-in-immune-mediated-inflammatory-diseases
#12
Murray W Enns, Charles N Bernstein, Kristine Kroeker, Lesley Graff, John R Walker, Lisa M Lix, Carol A Hitchon, Renée El-Gabalawy, John D Fisk, Ruth Ann Marrie
Impairment in work function is a frequent outcome in patients with chronic conditions such as immune-mediated inflammatory diseases (IMID), depression and anxiety disorders. The personal and economic costs of work impairment in these disorders are immense. Symptoms of pain, fatigue, depression and anxiety are potentially remediable forms of distress that may contribute to work impairment in chronic health conditions such as IMID. The present study evaluated the association between pain [Medical Outcomes Study Pain Effects Scale], fatigue [Daily Fatigue Impact Scale], depression and anxiety [Hospital Anxiety and Depression Scale] and work impairment [Work Productivity and Activity Impairment Scale] in four patient populations: multiple sclerosis (n = 255), inflammatory bowel disease (n = 248, rheumatoid arthritis (n = 154) and a depression and anxiety group (n = 307), using quantile regression, controlling for the effects of sociodemographic factors, physical disability, and cognitive deficits...
2018: PloS One
https://www.readbyqxmd.com/read/29875527/neuropsychological-functioning-in-euthymic-phase-of-bipolar-affective-disorder
#13
Priyanka Bhatia, Ajeet Sidana, Subhash Das, Manoj Kumar Bajaj
Background: A substantial proportion of euthymic bipolar disorder patients have neuropsychological impairment which can have a significant impact on the overall functional recovery. Materials and Methods: A total of 60 bipolar disorder patients, currently in euthymic phase for the last 3 months with minimum duration of illness 2 years and current Young Mania Rating Scale <7 and Hamilton Depression Rating Scale <6, currently on medications were administrated various neuropsychological tests...
May 2018: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29872391/negative-affect-influences-electrophysiological-markers-of-visual-working-memory-in-mildly-stressed-older-adults
#14
Tab R Memmott, Daniel Klee, Barry Oken
Negative affect (NA) has been related to lower working memory performance across all ages, including in older adults where it has been suggested as a marker for later cognitive impairments. However, NA-related decreases in working memory performance have not been shown in a full range of working memory paradigms or fully explored in the context of electrophysiological measures of working memory. We examined the impact of NA and related markers on an electroencephalography (EEG) marker of visual working memory (VWM) capacity, referred to as the contralateral delay activity (CDA)...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29867739/investigating-domain-specific-cognitive-impairment-among-patients-with-multiple-sclerosis-using-touchscreen-cognitive-testing-in-routine-clinical-care
#15
Jack Cotter, Nethmi Vithanage, Shuna Colville, Dawn Lyle, Denise Cranley, Francesca Cormack, Jennifer H Barnett, Katy Murray, Suvankar Pal
Cognitive dysfunction is present in up to 70% of patients with multiple sclerosis (MS) and has been reported at all stages and in all subtypes of the disease. These deficits have been reported across a variety of cognitive domains, but are generally under-recognized and incompletely evaluated in routine clinical practice. The aim of this study was to investigate the spectrum of cognitive impairment in patients with MS presenting to a specialist MS clinic using the Cambridge Neuropsychological Test Automated Battery (CANTAB), administered on a touchscreen platform...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29867697/outpatient-psychotherapy-improves-symptoms-and-reduces-health-care-costs-in-regularly-and-prematurely-terminated-therapies
#16
Uwe Altmann, Désirée Thielemann, Anna Zimmermann, Andrés Steffanowski, Ellen Bruckmeier, Irmgard Pfaffinger, Andrea Fembacher, Bernhard Strauß
Background: In view of a shortage of health care costs, monetary aspects of psychotherapy become increasingly relevant. The present study examined the pre-post reduction of impairment and direct health care costs depending on therapy termination (regularly terminated, dropout with an unproblematic reason, and dropout with a quality-relevant reason) and the association of symptom and cost reduction. Methods: In a naturalistic longitudinal study, we examined a disorder heterogeneous sample of N = 584 outpatients who were either treated with cognitive-behavioral, psychodynamic, or psychoanalytic therapy...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29859113/the-capability-set-for-work-correlates-of-sustainable-employability-in-workers-with-multiple-sclerosis
#17
D A M van Gorp, J J L van der Klink, F I Abma, P J Jongen, I van Lieshout, E P J Arnoldus, E A C Beenakker, H M Bos, J J J van Eijk, J Fermont, S T F M Frequin, K de Gans, G J D Hengstman, R M M Hupperts, J P Mostert, P H M Pop, W I M Verhagen, D Zemel, M A P Heerings, M F Reneman, H A M Middelkoop, L H Visser, K van der Hiele
BACKGROUND: The aim of this study was to examine whether work capabilities differ between workers with Multiple Sclerosis (MS) and workers from the general population. The second aim was to investigate whether the capability set was related to work and health outcomes. METHODS: A total of 163 workers with MS from the MS@Work study and 163 workers from the general population were matched for gender, age, educational level and working hours. All participants completed online questionnaires on demographics, health and work functioning...
June 1, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29847006/severe-role-impairment-associated-with-mental-disorders-results-of-the-who-world-mental-health-surveys-international-college-student-project
#18
Jordi Alonso, Philippe Mortier, Randy P Auerbach, Ronny Bruffaerts, Gemma Vilagut, Pim Cuijpers, Koen Demyttenaere, David D Ebert, Edel Ennis, Raul A Gutiérrez-García, Jennifer Greif Green, Penelope Hasking, Christine Lochner, Matthew K Nock, Stephanie Pinder-Amaker, Nancy A Sampson, Alan M Zaslavsky, Ronald C Kessler
BACKGROUND: College entrance is a stressful period with a high prevalence of mental disorders. AIMS: To assess the role impairment associated with 12-month mental disorders among incoming first-year college students within a large cross-national sample. METHODS: Web-based self-report surveys assessing the prevalence of DSM-IV mental disorders and health-related role impairment (Sheehan Disability Scale) were obtained and analyzed from 13,984 incoming first-year college students (Response = 45...
May 30, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29808011/impairment-in-delay-discounting-in-schizophrenia-and-schizoaffective-disorder-but-not-primary-mood-disorders
#19
Hannah E Brown, Kamber L Hart, Leslie A Snapper, Joshua L Roffman, Roy H Perlis
A measure of planning and impulse control, the delay-discounting (DD) task estimates the extent to which an individual decreases the perceived value of a reward as the reward is delayed. We examined cross-disorder performance between healthy controls (n = 88), individuals with bipolar disorder (n = 23), major depressive disorder (n = 43), and primary psychotic disorders (schizophrenia and schizoaffective disorder; n = 51) on the DD task (using a $10 delayed larger reward), as well as the interaction of DD scores with other symptom domains (cognition, psychosis, and affect)...
May 28, 2018: NPJ Schizophrenia
https://www.readbyqxmd.com/read/29805778/dissociative-symptoms-mediate-the-relation-between-ptsd-symptoms-and-functional-impairment-in-a-sample-of-military-members-veterans-and-first-responders-with-ptsd
#20
Jenna E Boyd, Alina Protopopescu, Charlene O'Connor, Richard W J Neufeld, Rakesh Jetly, Heather K Hood, Ruth A Lanius, Margaret C McKinnon
Background : Posttraumatic Stress Disorder (PTSD) is associated with significant functional impairment in important areas, including interpersonal relationships and occupational or educational roles. Preliminary evidence suggests that the dissociative subtype of PTSD (PTSD+DS), characterized by marked symptoms of depersonalization and derealization, is associated with increased functional impairment and disease severity, including among military members and veterans diagnosed with PTSD. Similarly, first responders (e...
2018: European Journal of Psychotraumatology
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