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Depression and work impairment

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https://www.readbyqxmd.com/read/27918444/mental-health-comorbidities-in-pediatric-chronic-pain-a-narrative-review-of-epidemiology-models-neurobiological-mechanisms-and-treatment
#1
REVIEW
Jillian Vinall, Maria Pavlova, Gordon J G Asmundson, Nivez Rasic, Melanie Noel
Chronic pain during childhood and adolescence can lead to persistent pain problems and mental health disorders into adulthood. Posttraumatic stress disorders and depressive and anxiety disorders are mental health conditions that co-occur at high rates in both adolescent and adult samples, and are linked to heightened impairment and disability. Comorbid chronic pain and psychopathology has been explained by the presence of shared neurobiology and mutually maintaining cognitive-affective and behavioral factors that lead to the development and/or maintenance of both conditions...
December 2, 2016: Children
https://www.readbyqxmd.com/read/27913207/overexpression-of-stim1-in-neurons-in-mouse-brain-improves-contextual-learning-and-impairs-long-term-depression
#2
Łukasz Majewski, Filip Maciąg, Paweł M Boguszewski, Iga Wasilewska, Grzegorz Wiera, Tomasz Wójtowicz, Jerzy Mozrzymas, Jacek Kuznicki
STIM1 is an endoplasmic reticulum calcium sensor that is involved in several processes in neurons, including store-operated calcium entry. STIM1 also inhibits voltage-gated calcium channels, such as Cav1.2 and Cav3.1, and is thus considered a multifunctional protein. The aim of this work was to investigate the ways in which transgenic neuronal overexpression of STIM1 in FVB/NJ mice affects animal behavior and the electrophysiological properties of neurons in acute hippocampal slices. We overexpressed STIM1 from the Thy1...
November 29, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27903327/auditory-vigilance-and-working-memory-in-youth-at-familial-risk-for-schizophrenia-or-affective-psychosis-in-the-harvard-adolescent-family-high-risk-study
#3
Larry J Seidman, Andrea Pousada-Casal, Silvia Scala, Eric C Meyer, William S Stone, Heidi W Thermenos, Elena Molokotos, Jessica Agnew-Blais, Ming T Tsuang, Stephen V Faraone
BACKGROUND: The degree of overlap between schizophrenia (SCZ) and affective psychosis (AFF) has been a recurring question since Kraepelin's subdivision of the major psychoses. Studying nonpsychotic relatives allows a comparison of disorder-associated phenotypes, without potential confounds that can obscure distinctive features of the disorder. Because attention and working memory have been proposed as potential endophenotypes for SCZ and AFF, we compared these cognitive features in individuals at familial high-risk (FHR) for the disorders...
November 2016: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/27901522/the-effect-of-remission-status-on-work-functioning-in-employed-patients-treated-for-major-depressive-disorder
#4
David Sarfati, Kurtis Stewart, Cindy Woo, Sagar V Parikh, Lakshmi N Yatham, Raymond W Lam
BACKGROUND: The ability to function at work is impaired in patients with major depressive disorder (MDD) but few clinical trials include occupational outcome assessments. This study examined whether symptom remission following treatment for MDD is associated with work functioning improvement. METHODS: We conducted a secondary analysis of a 12-week randomized clinical trial comparing escitalopram with or without telephone-administered cognitive therapy in employed patients with MDD (N = 86)...
November 1, 2016: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/27892842/complicated-grief-after-suicide-bereavement-and-other-causes-of-death
#5
Ilanit Tal, Christine Mauro, Charles F Reynolds, M Katherine Shear, Naomi Simon, Barry Lebowitz, Natalia Skritskaya, Yuanjia Wang, Xin Qiu, Alana Iglewicz, Danielle Glorioso, Julie Avanzino, Julie Loebach Wetherell, Jordan F Karp, Don Robinaugh, Sidney Zisook
We compared baseline demographic characteristics, clinical features, and grief-related thoughts, feelings and behaviors of individuals bereaved by suicide, accident/homicide and natural causes participating in a complicated grief (CG) treatment clinical trial. Severity of CG and depression and current depression diagnosis did not vary by loss type. After adjusting for baseline demographic features, time since death and relationship to the deceased, those with CG after suicide had the highest rates of lifetime depression, pre-loss passive suicidal ideation, self-blaming thoughts, and impaired work and social adjustment...
November 28, 2016: Death Studies
https://www.readbyqxmd.com/read/27869250/preliminary-analyses-of-psychometric-characteristics-of-the-polish-version-of-the-obsessive-compulsive-inventory-revised-oci-r-in-a-non-clinical-sample
#6
Justyna Mojsa-Kaja, Krystyna Golonka, Magda Gawłowska
OBJECTIVES: Obsessive-compulsive disorder (OCD) is an anxiety-spectrum disorder that affects 1-2% of the adult population. People with OCD are more likely to report impaired social and occupational functioning. Although effective treatments of the OCD exist, many sufferers from this disorder are continuously misdiagnosed. Therefore, improving the assessment of the OCD remains an important area of scientific research. The main goal of the study is the initial verification of psychometric properties in the Polish version of the Obsessive-Compulsive Inventory-Revised (OCI-R) in a college student sample...
November 18, 2016: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/27868437/can-we-address-depression-in-vision-rehabilitation-settings-professionals-perspectives-on-the-barriers-to-integrating-problem-solving-treatment
#7
Edith Holloway, Bonnie Sturrock, Ecosse Lamoureux, Jill Keeffe, Mark Hegel, Robin Casten, David Mellor, Gwyneth Rees
PURPOSE: Low vision rehabilitation (LVR) is a pertinent context for integrating early, evidence-based psychological interventions given the high prevalence of untreated depression in adults with vision impairment. This study aims to identify the perceived barriers and facilitators to staff-delivered telephone-based problem-solving treatment for primary care (PST-PC) offered as an integrated component of LVR. METHODS: Qualitative semi-structured interviews, developed using the theoretical domains framework (TDF) and Consolidated Framework for Implementation Research (CFIR), were conducted with 21 LVR professionals and a clinical psychologist involved in the delivery of PST-PC...
November 20, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27862658/a-double-blind-randomized-crossover-study-of-intravenous-infusion-of-magnesium-sulfate-versus-5-dextrose-on-depressive-symptoms-in-adults-with-treatment-resistant-depression
#8
Syed A Mehdi, Steven E Atlas, Sidra Qadir, Dominique Musselman, Sharon Goldberg, Judi M Woolger, Raul Corredor, Muhammad Hasnain Abbas, Leopoldo Arosemena, Simone Caccamo, Carmen Campbell, Ashar Farooqi, Jinrun Gao, Janet Konefal, Lucas C Lages, Laura Lantigua, Johanna Lopez, Vanessa Padilla, Ammar Rasul, Anna M Ray, Herbert Simões, Eduard Tiozzo, John E Lewis
AIM: Treatment-resistant depression patients are more likely to suffer from comorbid physical and mental disorders, experience marked and protracted functional impairment, and incur higher healthcare costs than non-affected individuals. Magnesium sulfate is a treatment option that may offer great potential for patients with treatment-resistant depression based on prior work in animals and humans. METHODS: Twelve subjects with mild or moderate treatment-resistant depression were randomized into a double-blind crossover trial to receive an infusion of 4 gram of magnesium sulfate in 5% dextrose or placebo infusion of 5% dextrose with a 5-day washout in between the 8-day intervention period...
November 10, 2016: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27861191/effects-of-levomilnacipran-extended-release-on-major-depressive-disorder-patients-with-cognitive-impairments-post-hoc-analysis-of-a-phase-iii-study
#9
Keith A Wesnes, Carl Gommoll, Changzheng Chen, Angelo Sambunaris, Roger S McIntyre, Philip D Harvey
Performance-based cognitive data were collected using the Cognitive Drug Research System in a study of levomilnacipran extended-release (ER) 40-120 mg/day (NCT01034462) in adults with major depressive disorder. These data were analyzed post-hoc to explore the relationship between cognitive measures, depression symptoms (Montgomery-Åsberg Depression Rating Scale, MADRS), and self-reported psychosocial functioning (Sheehan Disability Scale; SDS). Changes from baseline were analyzed in the intent-to-treat population and subgroups with impaired attention, as indicated by baseline Cognitive Drug Research System scores for Power of Attention and Continuity of Attention...
November 16, 2016: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27858347/serum-concentrations-of-mood-stabilizers-are-associated-with-memory-but-not-other-cognitive-domains-in-psychosis-spectrum-disorders-explorative-analyses-in-a-naturalistic-setting
#10
Nils Eiel Steen, Monica Aas, Carmen Simonsen, Ingrid Dieset, Martin Tesli, Mari Nerhus, Erlend Gardsjord, Ragni Mørch, Ingrid Agartz, Ingrid Melle, Anja Vaskinn, Olav Spigset, Ole A Andreassen
BACKGROUND: Mood stabilizers like lithium and anticonvulsants are used in bipolar and related psychotic disorders. There is a lack of knowledge of the relationship of these medications and cognition in the psychosis spectrum. We studied the association between serum concentration of mood stabilizers and cognitive performance in a well-characterized sample of bipolar and schizophrenia spectrum disorders. METHODS: Serum concentrations of valproate, lamotrigine, and lithium were analyzed for associations to performance on neuropsychological tests in six cognitive domains in individuals with bipolar disorder (n = 167) and in a combined sample of individuals with bipolar or schizophrenia spectrum disorders (n = 217)...
December 2016: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/27854287/caregiving-and-its-resulting-effects-the-care-study-to-evaluate-the-effects-of-caregiving-on-caregivers-of-patients-with-advanced-cancer-in-singapore
#11
Cheryl Kai Ting Chua, Jun Tian Wu, Yin Yee Wong, Limin Qu, Yung Ying Tan, Patricia Soek Hui Neo, Grace Suyin Pang
Informal caregivers (IC) are key to enabling home deaths, where preferred, at the end-of-life. Significant morbidity from advanced cancer can make caregiving burdensome. However, knowledge about the nature of the caregiving burden for caregivers in Singapore is limited. Hence, the key objective in this study was to examine the impact of the caregiving burden on quality of life (QOL), mental health and work capacity among local ICs. Eligible English-speaking ICs of hospitalized advanced cancer patients were recruited through non-random sampling...
November 15, 2016: Cancers
https://www.readbyqxmd.com/read/27837572/clinical-and-cognitive-factors-affecting-psychosocial-functioning-in-remitted-patients-with-bipolar-disorder
#12
G Konstantakopoulos, N Ioannidi, M Typaldou, D Sakkas, P Oulis
Impaired interpersonal, social, and occupational functioning is very often observed in patients with bipolar disorder, not only at the acute stages of the illness but in remission as well. This finding raises the question of multiple factors that might affect psychosocial functioning in bipolar patients, such as residual subsyndromal symptoms and neuropsychological deficits. Social cognition impairment, especially impaired Theory of Mind (ToM), might also play an important role in bipolar patients' every-day functioning, similarly to what was found in patients with schizophrenia...
July 2016: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/27827406/heterogeneity-of-executive-functions-among-comorbid-neurodevelopmental-disorders
#13
Dina R Dajani, Maria M Llabre, Mary Beth Nebel, Stewart H Mostofsky, Lucina Q Uddin
Executive functions (EFs) are used to set goals, plan for the future, inhibit maladaptive responses, and change behavior flexibly. Although some studies point to specific EF profiles in autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) - prevalent and often highly comorbid neurodevelopmental disorders - others have not differentiated them. The objective of the current study was to identify distinct profiles of EF across typically developing (TD) children and children with ASD and ADHD...
November 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27823734/predictors-of-sleep-disturbance-in-menopausal-transition
#14
Laura Lampio, Tarja Saaresranta, Janne Engblom, Olli Polo, Päivi Polo-Kantola
OBJECTIVE: This follow-up study aimed to evaluate risk factors for menopausal sleep disturbances already identifiable before menopause. METHODS: At baseline, all 81 women were premenopausal. At year-five follow-up, 27 of the women were premenopausal, 40 postmenopausal, and 14 postmenopausal and using hormone therapy. We used the Basic Nordic Sleep Questionnaire to study sleep; additional questionnaires evaluated risk factors for sleep impairment. RESULTS: Sleep quality differed only marginally between the groups...
December 2016: Maturitas
https://www.readbyqxmd.com/read/27820765/anxiety-and-depression-mediate-the-relationship-between-perceived-workplace-health-support-and-presenteeism-a-cross-sectional-analysis
#15
Sharon S Laing, Salene M W Jones
OBJECTIVE: This study investigates the mediation effect of anxiety and depression on the relationship between perceived health-promoting workplace culture and presenteeism. METHODS: Paper surveys were distributed to 4703 state employees. Variables included symptoms of depression (Patient Health Questionnaire-2 [PHQ-2]); anxiety (General Health Questionnaire-12 [GHQ-12]); perceived workplace support for healthy living and physical activity; and presenteeism (Work Productivity and Activity Impairment Questionnaire)...
November 2016: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27816701/viral-mediated-zif268-expression-in-the-prefrontal-cortex-protects-against-gonadectomy-induced-working-memory-long-term-memory-and-social-interaction-deficits-in-male-rats
#16
Amanda M Dossat, Hussam Jourdi, Katherine N Wright, Caroline E Strong, Ambalika Sarkar, Mohamed Kabbaj
In humans, some males experience reductions in testosterone levels, as a natural consequence of aging or in the clinical condition termed hypogonadism, which are associated with impaired cognitive performance and mood disorder(s). Some of these behavioral deficits can be reversed by testosterone treatment. Our previous work in rats reported that sex differences in the expression of the transcription factor Zif268, a downstream target of testosterone, within the medial prefrontal cortex (mPFC) mediates sex differences in social interaction...
November 2, 2016: Neuroscience
https://www.readbyqxmd.com/read/27810788/anthriscus-nemorosa-essential-oil-inhalation-prevents-memory-impairment-anxiety-and-depression-in-scopolamine-treated-rats
#17
Eyup Bagci, Emel Aydin, Eugen Ungureanu, Lucian Hritcu
Anthriscus nemorosa (Bieb.) Sprengel is used for medicinal purposes in traditional medicine around the world, including Turkey. Ethnobotanical studies suggest that Anthriscus essential oil could improve memory in Alzheimer's disease. The current study was hypothesized to investigate the beneficial effects of inhaled Anthriscus nemorosa essential oil on memory, anxiety and depression in scopolamine-treated rats. Anthriscus nemorosa essential oil was administered by inhalation in the doses of 1% and 3% for 21 continuous days and scopolamine (0...
October 29, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27810272/neurocognitive-performance-psychopathology-and-social-functioning-in-individuals-at-high-risk-for-schizophrenia-or-psychotic-bipolar-disorder
#18
Evgenia Gkintoni, Eleftherios G Pallis, Panos Bitsios, Stella G Giakoumaki
INTRODUCTION: Although cognitive deficits are consistent endophenotypes of schizophrenia and bipolar disorder, findings in psychotic bipolar disorder (BDP) are inconsistent. In this study we compared adult unaffected first-degree relatives of schizophrenia and BDP patients on cognition, psychopathology, social functioning and quality of life. METHODS: Sixty-six unaffected first-degree relatives of schizophrenia patients (SUnR), 36 unaffected first-degree relatives of BDP patients (BDPUnR) and 102 controls participated in the study...
October 24, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27808661/examining-pretreatment-differences-between-veterans-in-residential-versus-outpatient-treatment-for-alcohol-use-disorder-and-comorbid-combat-related-ptsd
#19
Moira Haller, Peter J Colvonen, Brittany C Davis, Ryan S Trim, Rebecca Bogner, John Sevcik, Sonya B Norman
OBJECTIVE: Veterans with alcohol use disorder (AUD) and co-occurring posttraumatic stress disorder (PTSD) have access to various residential and outpatient treatment programs through the VA Healthcare System. There is a need to better understand the characteristics and needs of veterans who engage in residential versus outpatient treatment in order to help inform veteran care and decisions about treatment services. METHODS: The present study examined whether veterans with both AUD and combat-related PTSD who were enrolled in residential (n = 103) or outpatient treatment programs (n = 76) differed on pretreatment psychiatric symptoms, substance use and associated problems/behaviors, or demographics...
July 2016: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/27808060/prevalence-and-determinants-of-depression-among-elderly-persons-in-a-rural-community-from-northern-india
#20
Priyamadhaba Behera, Pratap Sharan, Ashwani Kumar Mishra, Baridalyne Nongkynrih, Shashi Kant, Sanjeev Kumar Gupta
BACKGROUND: Globally, more than 350 million people of all ages suffer from depression. Elderly persons are more vulnerable to depression. We conducted this study to estimate the prevalence of depression, and to study the association of depression with sociodemographic and clinical variables among elderly persons in a rural community. METHODS: We conducted a community-based cross-sectional study among 395 randomly selected elderly persons aged 60 years and above in a rural area of Ballabgarh, Haryana, India...
May 2016: National Medical Journal of India
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