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https://www.readbyqxmd.com/read/29040988/unique-characteristics-associated-with-sustained-liver-damage-in-chronic-hepatitis-c-patients-treated-with-direct-acting-antivirals
#1
Masashi Kono, Naoshi Nishida, Satoru Hagiwara, Tomohiro Minami, Hirokazu Chishina, Tadaaki Arizumi, Kosuke Minaga, Ken Kamata, Yoriaki Komeda, Toshiharu Sakurai, Mamoru Takenaka, Masahiro Takita, Norihisa Yada, Hiroshi Ida, Yasunori Minami, Kazuomi Ueshima, Tomohiro Watanabe, Masatoshi Kudo
BACKGROUND AND AIMS: Direct-acting antivirals (DAAs) dramatically improve the sustained virological response (SVR) of chronic hepatitis C (CHC) patients. However, continuous liver damage after SVR may be a risk of hepatocellular carcinoma (HCC). We clarified pretreatment characteristics related to sustained liver damage after SVR. METHODS: A total of 286 CHC patients were treated with an interferon-free DAA regimen. Among them, 250 patients achieved SVR for 12 weeks after the end of treatment (SVR12); these individuals were classified based on α-fetoprotein (AFP) and alanine transaminase (ALT) levels posttreatment...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/29040987/hepatocarcinogenesis-is-associated-with-serum-albumin-levels-after-sustained-virological-responses-with-interferon-based-therapy-in-patients-with-hepatitis-c
#2
Yasuko Umehara, Satoru Hagiwara, Naoshi Nishida, Toshiharu Sakurai, Hiroshi Ida, Yasunori Minami, Masahiro Takita, Tomohiro Minami, Hirokazu Chishina, Kazuomi Ueshima, Yoriaki Komeda, Tadaaki Arizumi, Tomohiro Watanabe, Masatoshi Kudo
OBJECTIVE: It is a generally accepted fact that eradication of hepatitis virus C inhibits the subsequent development of hepatocellular carcinoma (HCC). On the contrary, a significant population of patients developed HCC despite sustained virological responses (SVRs) to interferon (IFN) therapy. METHODS: A total of 415 patients with chronic hepatitis C, who were treated at our hospital between 2004 and 2014, were enrolled for this study. We examined the risk factors for HCC development after IFN therapy...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/29040986/comparison-of-sofosbuvir-plus-ribavirin-treatment-with-pegylated-interferon-plus-ribavirin-treatment-for-chronic-hepatitis-c-genotype-2
#3
Kayo Seo, Soo Ki Kim, Soo Ryang Kim, Aya Ohtani, Mana Kobayashi, Airi Kato, Eri Morimoto, Yuka Saijo, Ke Ih Kim, Susumu Imoto, Chi Wan Kim, Yoshihiko Yano, Masatoshi Kudo, Yoshitake Hayashi
BACKGROUND: Sofosbuvir plus ribavirin (RBV) therapy showed higher sustained virological response at 12 weeks after treatment (SVR12) than pegylated interferon (peg-IFN) plus RBV; however, liver function, fibrosis, and hepatocellular carcinoma markers have not been assessed so far. SUMMARY: Patients (n = 21) receiving Sofosbuvir plus RBV and those (n = 24) receiving peg-IFN plus RBV were enrolled in this study. Changes in alanine aminotransferase (ALT) and α-fetoprotein (AFP) levels, platelet (PLT) counts, FIB-4, and aspartate aminotransferase-to-platelet ratio index (APRI) in both groups were assessed in patients achieving SVR12...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/29040983/diagnosis-of-fibrosis-and-activity-by-a-combined-use-of-strain-and-shear-wave-imaging-in-patients-with-liver-disease
#4
Norihisa Yada, Nobuhura Tamaki, Yohei Koizumi, Masashi Hirooka, Osamu Nakashima, Yoichi Hiasa, Namiki Izumi, Masatoshi Kudo
OBJECTIVE: Performing shear wave imaging is simple, but can be difficult when inflammation, jaundice, and congestion are present. Therefore, the correct diagnosis of liver fibrosis using shear wave imaging alone might be difficult in mild-to-moderate fibrosis cases. Strain imaging can diagnose liver fibrosis without the influence of inflammation. Therefore, the combined use of strain and shear wave imaging (combinational elastography) for cases without jaundice and congestion might be useful for evaluating fibrosis and inflammation...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/29035910/new-predictive-factors-of-poor-response-to-therapy-in-autoimmune-hepatitis-role-of-mean-platelet-volume
#5
Ahmed Abdel-Razik, Nasser Mousa, Sahar Zakaria, Rania Elhelaly, Rasha Elzehery, Khaled Zalata, Mahmoud Awad, Ahmed A Eldeeb, Mostafa Abdelsalam
BACKGROUND AND OBJECTIVES: The response to immunosuppressive therapy in autoimmune hepatitis (AIH) is a matter of debate. The aim of this work is to identify the histological, biochemical, and clinical predictive factors of incomplete response/treatment failure to the standard treatment (prednisone with or without azathioprine) in a well-characterized series of AIH Egyptian patients. PATIENTS AND METHODS: Of 49 AIH patients, only 36 patients completed this retrospective cohort study...
October 13, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29035816/docosahexaenoic-acid-attenuates-carbon-tetrachloride-induced-hepatic-fibrosis-in-rats
#6
Jianlin He, Kaikai Bai, Bihong Hong, Feng Zhang, Shizhong Zheng
Fish oil containing docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) has been reported to exert beneficial health effects, including hepatoprotection. However, the effect of DHA alone has not been well studied, and the mechanism is not fully understood. In the present study, we reported the protective effect of DHA on carbon tetrachloride (CCl4) induced hepatic fibrosis. Compared with the control group, the CCl4 group showed hepatic damage as evidenced by histological changes and elevation in serum transaminase activity, fibrosis, inflammation and oxidative stress levels...
October 13, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29035375/upregulation-of-the-actin-cytoskeleton-via-myocardin-leads-to-increased-expression-of-type-1-collagen
#7
Zengdun Shi, Don C Rockey
Liver fibrosis, a model wound healing system, is characterized by excessive deposition of extracellular matrix (ECM) in the liver. Although many fibrogenic cell types may express ECM, the hepatic stellate cell (HSC) is currently considered to be the major effector. HSCs transform into myofibroblast-like cells, also known as hepatic myofibroblasts in a process known as activation; this process is characterized in particular by de novo expression of smooth muscle alpha actin (SM α-actin) and type 1 collagen...
October 16, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29034239/hepatoid-adenocarcinoma-of-the-stomach-a-challenging-diagnostic-and-therapeutic-disease-through-a-case-report-and-review-of-the-literature
#8
Najla Fakhruddin, Hisham F Bahmad, Tarek Aridi, Yara Yammine, Rami Mahfouz, Fouad Boulos, Ahmad Awada, Fadi Farhat
Hepatoid adenocarcinoma of the stomach (HAS) is a rare aggressive tumor with hepatocellular differentiation. HAS often produces alpha fetoprotein (AFP) and metastasizes to the lymph nodes and the liver. Molecular studies revealed Her2 amplification and overexpression, association with p53 mutations, but no association with KRAS mutations. EGFR and BRAF mutations have not yet been evaluated in hepatoid carcinoma of the stomach so far. Hereby, we present a case of a 41-year-old female patient with HAS with high AFP level and liver metastases...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29033906/long-non-coding-rnas-in-hepatitis-c-virus-infected-cells
#9
REVIEW
Marina Barriocanal, Puri Fortes
Hepatitis C virus (HCV) often leads to a chronic infection in the liver that may progress to steatosis, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Several viral and cellular factors are required for a productive infection and for the development of liver disease. Some of these are long non-coding RNAs (lncRNAs) deregulated in infected cells. After HCV infection, the sequence and the structure of the viral RNA genome are sensed to activate interferon (IFN) synthesis and signaling pathways. These antiviral pathways regulate transcription of several cellular lncRNAs...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29033837/dioscin-inhibits-hsc-t6-cell-migration-via-adjusting-sdc-4-expression-insights-from-itraq-based-quantitative-proteomics
#10
Lianhong Yin, Yan Qi, Youwei Xu, Lina Xu, Xu Han, Xufeng Tao, Shasha Song, Jinyong Peng
Hepatic stellate cells (HSCs) migration, an important bioprocess, contributes to the development of liver fibrosis. Our previous studies have found the potent activity of dioscin against liver fibrosis by inhibiting HSCs proliferation, triggering the senescence and inducing apoptosis of activated HSCs, but the molecular mechanisms associated with cell migration were not clarified. In this work, iTRAQ (isobaric tags for relative and absolution quantitation)-based quantitative proteomics study was carried out, and a total of 1566 differentially expressed proteins with fold change ≥2...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29033567/nanoparticles-for-the-treatment-of-liver-fibrosis
#11
REVIEW
Suchithra Poilil Surendran, Reju George Thomas, Myeong Ju Moon, Yong Yeon Jeong
Chronic liver diseases represent a global health problem due to their high prevalence worldwide and the limited available curative treatment options. They can result from various causes, both infectious and noninfectious diseases. The application of nanoparticle (NP) systems has emerged as a rapidly evolving area of interest for the safe delivery of various drugs and nucleic acids for chronic liver diseases. This review presents the pathogenesis, diagnosis and the emerging nanoparticulate systems used in the treatment of chronic liver diseases caused by liver fibrosis...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29031875/soluble-epoxide-hydrolase-inhibition-with-t-tucb-alleviates-liver-fibrosis-and-portal-pressure-in-carbon-tetrachloride-induced-cirrhosis-in-rats
#12
Chi-Hao Zhang, Lei Zheng, Liang Gui, Jia-Yun Lin, Yi-Ming Zhu, Wen-Sheng Deng, Meng Luo
BACKGROUND/AIMS: Fibrosis and increased intrahepatic vascular resistance are the hallmarks of chronic inflammatory disorders of the liver and cirrhosis. Inhibitors of the enzyme soluble epoxide hydrolase reduce fibrosis in several disease models. The present study aimed at investigating the effects of soluble epoxyhydrolase inhibition with t-TUCB in tetrachloride-induced cirrhosis in rats. METHODS: The models were established by CCl4 (2ml/kg) given subcutaneously for 14 weeks...
October 11, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29029891/imaging-findings-within-the-first-12%C3%A2-months-of-hepatocellular-carcinoma-treated-with-stereotactic-body-radiation-therapy
#13
Mishal Mendiratta-Lala, Everett Gu, Dawn Owen, Kyle C Cuneo, Latifa Bazzi, Theodore S Lawrence, Hero K Hussain, Matthew S Davenport
PURPOSE: To correlate the imaging findings of treated hepatocellular carcinoma (HCC) after stereotactic body radiation therapy (SBRT) with explant pathology and alpha-fetoprotein (AFP) response. METHODS AND MATERIALS: From 2007 to 2015, of 146 patients treated with liver SBRT for Barcelona Clinic Liver Cancer stage A hepatocellular carcinoma, 10 were identified with inclusion criteria and had regular interval follow-up magnetic resonance imaging/triple phase computed tomography and explant pathology or declining AFP values for radiology-pathology response correlation...
August 24, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29029395/rasal1-is-a-potent-regulator-of-hepatic-stellate-cell-activity-and-liver-fibrosis
#14
Akemi Takata, Motoyuki Otsuka, Takahiro Kishikawa, Mari Yamagami, Rei Ishibashi, Kazuma Sekiba, Tatsunori Suzuki, Motoko Ohno, Yui Yamashita, Takaya Abe, Ryota Masuzaki, Tsuneo Ikenoue, Kazuhiko Koike
Liver fibrosis, leading to cirrhosis and liver failure, can occur after chronic liver injury. The transition of hepatic stellate cells (HSCs) from quiescent cells into proliferative and fibrogenic cells is a central event in liver fibrosis. Here, we show that RAS protein activator like-1 (RASAL1), a RAS-GTPase-activating protein, which switches off RAS activity, is significantly decreased during HSC activation, and that HSC activation can be antagonized by forced expression of the RASAL1 protein. We demonstrate that RASAL1 suppresses HSC proliferation by regulating the Ras-MAPK pathway, and that RASAL1 suppresses HSC fibrogenic activity by regulating the PKA-LKB1-AMPK-SRF pathway by interacting with angiotensin II receptor, type 1...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29026473/hepatitis-c-genotypes-in-libya-correlation-with-patients-characteristics-level-of-viremia-and-degree-of-liver-fibrosis
#15
Abdel-Naser Elzuoki, Islam Elzouki, Sabah Albarassi, Mohamed Gammo, Abdalla Burwaiss
OBJECTIVES: Our study sought to determine the distribution of hepatitis C virus (HCV)-genotypes among patients attending two tertiary care hospitals in Benghazi and Tripoli, Libya, and correlate this with patient's characteristics, viral load, and degree of fibrosis. METHODS: We conducted a retrospective study of 286 HCV-RNA positive Libyan patients referred from different health care facilities in east and west Libya for specific HCV treatment. HCV genotyping was carried out by gene amplification...
September 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29026311/artesunate-prevents-rats-from-the-clozapine-induced-hepatic-steatosis-and-elevation-in-plasma-triglycerides
#16
Yanmei Li, Ruibing Su, Shuqin Xu, Qingjun Huang, Haiyun Xu
Clozapine is an atypical antipsychotic with therapeutic efficacy in treatment-resistant schizophrenia patients and low incidence of extrapyramidal side effects. However, the use of clozapine has been limited by its adverse effects on metabolism. Artesunate is a semisynthetic derivative of artemisinin and was shown to decrease the plasma cholesterol and triglyceride in rabbits and rats in recent studies. The aim of this study was to examine possible effects of artesunate on the clozapine-induced metabolic alterations in rats given saline, clozapine, artesunate, or clozapine plus artesunate for 6 weeks...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29025246/vaspin-mrna-levels-in-the-liver-of-morbidly-obese-women-with-nonalcoholic-fatty-liver-disease
#17
Marek Waluga, Michał Kukla, Michał Żorniak, Marta Grabiec, Maciej Kajor, Michał Dyaczyński, Grzegorz Kowalski, Dominika Żądło, Agnieszka Berdowska, Rafał Kotulski, Rafał J Bułdak, Tomasz Sawczyn, Ewa Waluga, Paweł Olczyk, Marek Hartleb
The aim of this study was to evaluate hepatic vaspin mRNA in morbidly obese women with nonalcoholic fatty liver disease (NAFLD) and to look for its relationships with metabolic and histopathological features. The study included 56 severely obese women who underwent intraoperative wedge liver biopsy during bariatric surgery. Hepatic vaspin mRNA was assessed by quantitative real-time PCR. Vaspin mRNA found in all included patients was markedly higher in patients with body mass index (BMI) ≥ 40 kg/m2 (4.59 ±3...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29025245/hepatic-chemerin-mrna-in-morbidly-obese-patients-with-nonalcoholic-fatty-liver-disease
#18
Maciej Kajor, Michał Kukla, Marek Waluga, Łukasz Liszka, Michał Dyaczyński, Grzegorz Kowalski, Dominika Żądło, Agnieszka Berdowska, Mateusz Chapuła, Anna Kostrząb-Zdebel, Rafał J Bułdak, Tomasz Sawczyn, Marek Hartleb
The aim of this study was to investigate hepatic chemerin mRNA, serum chemerin concentration, and immunohistochemical staining for chemerin and and chemokine receptor-like 1 (CMKLR1) in hepatic tissue in 56 morbidly obese women with nonalcoholic fatty liver disease (NAFLD) and to search for a relationship with metabolic and histopathological features. Chemerin mRNA was assessed by quantitative real-time PCR, chemerin, and CMKLR1 immunohistochemical expression with specific antibodies, while serum chemerin concentration was assessed with commercially available enzyme-linked immunosorbent assays...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29024407/ghrelin-deletion-protects-against-age-associated-hepatic-steatosis-by-downregulating-the-c-ebp%C3%AE-p300-dgat1-pathway
#19
Bobby Guillory, Nicole Jawanmardi, Polina Iakova, Barbara Anderson, Pu Zang, Nikolai A Timchenko, Jose M Garcia
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. NAFLD usually begins as low-grade hepatic steatosis which further progresses in an age-dependent manner to nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma in some patients. Ghrelin is a hormone known to promote adiposity in rodents and humans, but its potential role in hepatic steatosis is unknown. We hypothesized that genetic ghrelin deletion will protect against the development of age-related hepatic steatosis...
October 12, 2017: Aging Cell
https://www.readbyqxmd.com/read/29023927/hepatitis-b-virus-dual-infection-disrupts-platelet-count-recovery-in-chronic-hepatitis-c-patients-with-curative-antiviral-therapy
#20
Chung-Feng Huang, Ming-Lun Yeh, Ching-I Huang, Zu-Yau Lin, Shinn-Cherng Chen, Chia-Yen Dai, Jee-Fu Huang, Wan-Long Chuang, Ming-Lung Yu
BACKGROUND/AIMS: Hepatitis C virus (HCV) infection is associated with thrombocytopenia. Thrombocytopenia recovers after viral eradication. The current study explored the rate and factors associated with platelet (PLT) recovery, which may represent the degree of liver fibrosis regression. METHODS: A total of 466 patients who achieved a sustained virological response (SVR) were enrolled to compare the PLT change after a mean follow-up period of 85.5months (range 12-163 months)...
October 11, 2017: Journal of Gastroenterology and Hepatology
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