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Depression and work impairement

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https://www.readbyqxmd.com/read/29788128/sleep-patterns-and-problems-among-army-national-guard-soldiers
#1
Lucas P Hansen, Caroline Kinskey, Erin Koffel, Melissa Polusny, John Ferguson, Sonja Schmer-Galunder, Christopher R Erbes
Introduction: Adequate sleep plays an integral role in the physical and mental health of individuals, while simultaneously influencing their cognitive and work performance. Having recognized this, the U.S. Army has focused efforts on improving soldiers' healthy sleep behaviors. This study examines the extent to which mental health, alcohol use, and certain sleep hygiene behaviors predict sleep problems within an Army National Guard sample (N = 438). Materials and Methods: This manuscript is part of a larger study approved through the Minneapolis Veterans Affairs Medical Center Institutional Review Board...
May 18, 2018: Military Medicine
https://www.readbyqxmd.com/read/29785584/interferon-free-therapy-in-hepatitis-c-virus-hcv-monoinfected-and-hcv-hiv-coinfected-patients-effect-on-cognitive-function-fatigue-and-mental-health
#2
Felix Kleefeld, Sophie Heller, Patrick Ingiliz, Heiko Jessen, Anders Petersen, Ute Kopp, Antje Kraft, Katrin Hahn
The efficacy and safety of interferon-free therapies for hepatitis C virus (HCV) infection have been reported. Considering the accumulating evidence for a direct central nervous system infection by HCV, we aim to evaluate the effect of direct acting antivirals (DAA) therapy on cognitive function in HCV patients. We conducted a longitudinal analysis of the cognitive performance of 22 patients (8 HCV+, 14 HCV+/HIV+) who completed neuropsychological testing at baseline and at week 12 after DAA therapy. In 20 patients, we analyzed specific attention parameters derived from an experimental testing based on the Theory of Visual Attention (TVA)...
May 21, 2018: Journal of Neurovirology
https://www.readbyqxmd.com/read/29778804/emotion-introspection-and-regulation-in-depression
#3
Uwe Herwig, Sarah Opialla, Katja Cattapan, Thomas C Wetter, Lutz Jäncke, Annette B Brühl
Depressed patients suffer from an impairment to voluntarily influence and regulate their unpleasant emotional state. Strengthening the mental ability to interfere with dysfunctional emotion processing may be beneficial in treating depression. According to models of emotion processing this may be done by successful down-regulation of enhanced amygdala activity. We investigated short periods of intentional emotion-introspection compared with cognitive self-reflection as two domains of self-awareness in terms of effects on emotion regulation...
May 9, 2018: Psychiatry research. Neuroimaging
https://www.readbyqxmd.com/read/29777198/aberrant-working-memory-processing-in-major-depression-evidence-from-multivoxel-pattern-classification
#4
Matti Gärtner, M Elisabetta Ghisu, Milan Scheidegger, Luisa Bönke, Yan Fan, Anna Stippl, Ana-Lucia Herrera-Melendez, Sophie Metz, Emilia Winnebeck, Maria Fissler, Anke Henning, Malek Bajbouj, Karsten Borgwardt, Thorsten Barnhofer, Simone Grimm
Major depressive disorder (MDD) is often accompanied by severe impairments in working memory (WM). Neuroimaging studies investigating the mechanisms underlying these impairments have produced conflicting results. It remains unclear whether MDD patients show hyper- or hypoactivity in WM-related brain regions and how potential aberrations in WM processing may contribute to the characteristic dysregulation of cognition-emotion interactions implicated in the maintenance of the disorder. In order to shed light on these questions and to overcome limitations of previous studies, we applied a multivoxel pattern classification approach to investigate brain activity in large samples of MDD patients (N = 57) and matched healthy controls (N = 61) during a WM task that incorporated positive, negative, and neutral stimuli...
May 2, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29771474/neurocog-fx-study-a-multicenter-cohort-study-on-cognitive-dysfunction-in-patients-with-early-breast-cancer
#5
Oliver Rick, Monika Reuß-Borst, Timm Dauelsberg, Holger Hass, Volker König, Reiner Caspari, Gabriele Götz-Keil, Jürgen Pfitzner, Christa Kerschgens, Klaus Fliessbach, Christian Hoppe
OBJECTIVE: Complaints about cognitive dysfunction (CD) reportedly persist in approximately one third of breast cancer patients but the nature of CD and possible risk factors are unknown. METHODS: A cross-sectional, multicenter study was set-up at 9 German oncological rehabilitation centers. Objective cognitive performance was assessed by the NeuroCog FX test, a short computerized screening (duration <30 min) which assesses working memory, alertness, verbal/figural memory and language/executive...
May 17, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29768955/results-of-a-real-world-study-on-vortioxetine-in-patients-with-major-depressive-disorder-in-south-east-asia-revida
#6
Cheuk Ngen Chin, Azhar Zain, Solaphat Hemrungrojn, Eng Khean Ung, Patanon Kwansanit, Koon Choong Au Yong, Marvin Swee Woon Chong, Chalowat Inpa, Teck Hoe Yen, Boon Beng David Yeoh, Liam Kai Tay, Carmina Bernardo, Lionel Chee-Chong Lim, Chin Hong Yap, Calvin Fones, Ashwini Nayak, Lars Nelleman
OBJECTIVE: The REVIDA study aimed to assess the evolution of major depression symptoms in South East Asian (SEA) patients treated with vortioxetine for major depression in real-world clinical practice. METHODS: This non-interventional study was conducted from Aug 2016 to Apr 2017. A total of 138 patients (aged 18-65 years) with an active episode of major depression were recruited from Malaysia, Philippines, Singapore, and Thailand. Vortioxetine was initiated on the first visit and patients were followed for 3 months...
May 17, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29767395/behavioral-therapy-approaches-for-the-management-of-low-back-pain-an-up-to-date-systematic-review
#7
REVIEW
Kristallia Vitoula, Annalena Venneri, Giustino Varrassi, Antonella Paladini, Panagiota Sykioti, Joy Adewusi, Panagiotis Zis
Low back pain is one of the most common causes for seeking medical treatment and it is estimated that one in two people will experience low back pain at some point during their lifetimes. Management of low back pain includes pharmacological and non-pharmacological approaches. Non-pharmaceutical treatments include interventions such as acupuncture, spinal manipulation, and psychotherapy. The latter is especially important as patients who suffer from low back pain often have impaired quality of life and also suffer from depression...
May 16, 2018: Pain and Therapy
https://www.readbyqxmd.com/read/29762677/anti-dementia-drugs-for-psychopathology-and-cognitive-impairment-in-schizophrenia-a-systematic-review-and-meta-analysis
#8
Taro Kishi, Toshikazu Ikuta, Kazuto Oya, Shinji Matsunaga, Yuki Matsuda, Nakao Iwata
Background: We conducted a systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials of anti-dementia drugs plus antipsychotics (ADD+AP) for schizophrenia. Methods: Primary outcomes of efficacy and safety included improving overall symptoms (Positive and Negative Syndrome Scale and Brief Psychiatric Rating Scale scores) and all-cause discontinuation, respectively. Other outcomes included psychopathology subscales (positive, negative, general, and anxiety/depressive symptoms), cognitive function (attention/vigilance, reasoning/problem solving, social cognition, speed of processing, verbal learning, visual learning, working memory, and cognitive control/executive function), Mini-Mental State Examination (MMSE) scores, treatment discontinuation due to adverse events and inefficacy, and individual adverse events...
May 14, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29759090/perceived-discrimination-and-emotional-reactions-in-people-with-different-types-of-disabilities-a-qualitative-approach
#9
Daniel Pérez-Garín, Patricia Recio, Alejandro Magallares, Fernando Molero, Cristina García-Ael
The purpose of this study is to assess the discourse of people with disabilities regarding their perception of discrimination and stigma. Semi-structured interviews were conducted with ten adults with physical disabilities, ten with hearing impairments and seven with visual impairments. The agreement between the coders showed an excellent reliability for all three groups, with kappa coefficients between .82 and .96. Differences were assessed between the three groups regarding the types of discrimination they experienced and their most frequent emotional responses...
May 15, 2018: Spanish Journal of Psychology
https://www.readbyqxmd.com/read/29747716/effects-of-antiparkinson-medication-on-cognition-in-parkinson-s-disease-a-systematic-review
#10
Marc-André Roy, Maxime Doiron, Jessica Talon-Croteau, Nicolas Dupré, Martine Simard
OBJECTIVE: This study aimed to systematically review the effects of currently prescribed antiparkinson medication on cognition in patients with mild-to-moderate Parkinson's disease (PD) who were either cognitively intact or mildly impaired. METHODS: English- and French-language studies published between 1969 and 2017 were accessed via MedLine, PsychNET, EMBASE and EBSCO databases. Methodological quality (MQ) was evaluated with the quality assessment instrument of the Cochrane Collaboration Depression, Anxiety and Neurosis Review (scores from 0% to 44% indicate very low quality; scores from 45% to 64% indicate low quality; scores from 65% to 84% indicate medium quality; and scores from 85% to 100% indicate high quality)...
May 11, 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29747665/comprehensive-behavioral-analysis-of-mice-deficient-in-rapgef2-and-rapgef6-a-subfamily-of-guanine-nucleotide-exchange-factors-for-rap-small-gtpases-possessing-the-ras-rap-associating-domain
#11
Kazuhiro Maeta, Satoko Hattori, Junji Ikutomo, Hironori Edamatsu, Shymaa E Bilasy, Tsuyoshi Miyakawa, Tohru Kataoka
Rapgef2 and Rapgef6 define a subfamily of guanine nucleotide exchange factors for Rap small GTPases, characterized by the possession of the Ras/Rap-associating domain. Previous genomic analyses suggested their possible involvement in the etiology of schizophrenia. We recently demonstrated the development of an ectopic cortical mass (ECM), which resembles the human subcortical band heterotopia, in the dorsal telencephalon-specific Rapgef2 conditional knockout (Rapgef2-cKO) brains. Additional knockout of Rapgef6 in Rapgef2-cKO mice resulted in gross enlargement of the ECM whereas knockout of Rapgef6 alone (Rapgef6-KO) had no discernible effect on the brain morphology...
May 10, 2018: Molecular Brain
https://www.readbyqxmd.com/read/29744872/profound-consequences-of-hidradenitis-suppurativa-a-review
#12
REVIEW
Ł Matusiak
Hidradenitis suppurativa (HS) influences patients' lives in many ways. The most troublesome symptom of HS is chronic pain, of mild-to-moderate intensity, which is reported by almost all patients. With reference to psychosocial evaluation, HS appears to be a highly debilitating disease. The major factors influencing patients' well-being are disease severity, the number of flares or affected skin areas, and the lesion location. The mean Dermatology Life Quality Index scores of 8·3-12·7 points obtained among patients with HS are typical for severe dermatoses, which have a large impact on patients' quality of life (QoL)...
May 9, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29732526/neuroprotective-evidence-of-alpha-lipoic-acid-and-desvenlafaxine-on-memory-deficit-in-a-neuroendocrine-model-of-depression
#13
Caren Nádia Soares de Sousa, Lucas Nascimento Meneses, Germana Silva Vasconcelos, Ingridy da Silva Medeiros, Márcia Calheiros Chaves Silva, Fayçal Mouaffak, Oussama Kebir, Cláudio Manuel Gonçalves da Silva Leite, Manoel Cláudio Azevedo Patrocinio, Danielle Macedo, Silvânia Maria Mendes Vasconcelos
Cognitive impairment is present in patients with depression. We hypothesized that alpha-lipoic acid (ALA) can reduce cognitive impairment, especially when combined to antidepressants. Female mice received vehicle or corticosterone (CORT) 20 mg/kg, s.c. for 14 days. From the 15th to 21st day, the animals were divided in groups: vehicle, CORT, CORT+desvenlafaxine (DVS) 10 or 20 mg/kg, ALA 100 or 200 mg/kg, DVS10+ALA100, DVS20+ALA100, DVS10+ALA200, or DVS20+ALA200. Tail suspension (TST), social interaction (SIT), novel object recognition (NOR), and Y-maze tests were conducted...
May 7, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29726004/factors-associated-with-poor-functional-outcome-in-bipolar-disorder-sociodemographic-clinical-and-neurocognitive-variables
#14
J Sanchez-Moreno, C M Bonnin, A González-Pinto, B L Amann, B Solé, V Balanzá-Martinez, C Arango, E Jiménez, R Tabarés-Seisdedos, M P Garcia-Portilla, A Ibáñez, J M Crespo, J L Ayuso-Mateos, A Martinez-Aran, C Torrent, E Vieta
OBJECTIVE: The current investigation aimed at studying the sociodemographic, clinical, and neuropsychological variables related to functional outcome in a sample of euthymic patients with bipolar disorder(BD) presenting moderate-severe levels of functional impairment. METHODS: Two-hundred and thirty-nine participants with BD disorders and with Functioning Assessment Short Test(FAST) scores equal or above 18 were administered a clinical and diagnostic interview, and the administration of mood measure scales and a comprehensive neuropsychological battery...
May 3, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29719722/an-aggravated-return-to-work-case-of-organic-solvent-induced-chronic-toxic-encephalopathy
#15
Sangyun Seo, Jungwon Kim
Background: Organic solvent-induced chronic toxic encephalopathy (CTE) is known as a non-progressive disorder that does not progress after diagnosis. The authors present a case those symptoms worsened after continued exposure to organic solvent after returning to work. Because such a case has not been reported in South Korea to the best of our knowledge, we intend to report this case along with literature review. Case presentation: A 59-year-old man, who performed painting job at a large shipyard for 20 years, was receiving hospital treatment mainly for depression...
2018: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29716660/a-blended-psychosocial-support-program-for-partners-of-patients-with-amyotrophic-lateral-sclerosis-and-progressive-muscular-atrophy-protocol-of-a-randomized-controlled-trial
#16
Jessica de Wit, Anita Beelen, Constance H C Drossaert, Ruud Kolijn, Leonard H van den Berg, Johanna M A Visser-Meily, Carin D Schröder
BACKGROUND: Informal caregivers of patients with Amyotrophic Lateral Sclerosis (ALS) or Progressive Muscular Atrophy (PMA) face stressful demands due to severe impairments and prospect of early death of the patients they care for. Caregivers often experience feelings of psychological distress and caregiver burden, but supportive interventions are lacking. The objective of this study is to investigate the effectiveness of a psychosocial support program aimed at enhancing feelings of control over caregiving tasks and reducing psychological distress...
May 2, 2018: BMC Psychology
https://www.readbyqxmd.com/read/29713135/longitudinal-evaluation-of-the-role-of-academic-and-social-impairment-and-parent-adolescent-conflict-in-the-development-of-depression-in-adolescents-with-adhd
#17
Hana-May Eadeh, Elizaveta Bourchtein, Joshua M Langberg, Laura D Eddy, Lauren Oddo, Stephen J Molitor, Steven W Evans
Older adolescents with attention-deficit/hyperactivity disorder (ADHD) have a significantly increased likelihood of developing comorbid depression. It is important to evaluate factors during the early adolescent period that may contribute to this risk. A predominant theory is that impairment and failure experiences lead to the development of low-self efficacy and depression, and that parent and family factors also play a role. In a sample of 326 young adolescents with ADHD ( Mage = 12), the present study evaluated whether parent-adolescent conflict mediated the association between social and academic impairment and the development of depression...
September 2017: Journal of Child and Family Studies
https://www.readbyqxmd.com/read/29697881/the-dsm-5-nonsuicidal-self-injury-disorder-among-incoming-college-students-prevalence-and-associations-with-12-month-mental-disorders-and-suicidal-thoughts-and-behaviors
#18
Glenn Kiekens, Penelope Hasking, Laurence Claes, Philippe Mortier, Randy P Auerbach, Mark Boyes, Pim Cuijpers, Koen Demyttenaere, Jennifer G Green, Ronald C Kessler, Matthew K Nock, Ronny Bruffaerts
BACKGROUND: Approximately one in five college students report a history of nonsuicidal self-injury. However, it is unclear how many students meet criteria for the recently proposed DSM-5 nonsuicidal self-injury disorder (NSSI-D). In this study, we used full NSSI-D criteria to identify those students most in need of clinical care. METHODS: Using data from the Leuven College Surveys (n = 4,565), we examined the 12-month prevalence of DSM-5 NSSI-D in a large and representative sample of incoming college students...
April 26, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29693483/rehabilitation-for-improved-cognition-in-patients-with-stress-related-exhaustion-disorder-reco-a-randomized-clinical-trial
#19
Hanna Malmberg Gavelin, Therese Eskilsson, Carl-Johan Boraxbekk, Maria Josefsson, Anna Stigsdotter Neely, Lisbeth Slunga Järvholm
Stress-related exhaustion has been associated with selective and enduring cognitive impairments. However, little is known about how to address cognitive deficits in stress rehabilitation and how this influences stress recovery over time. The aim of this open-label, parallel randomized controlled trial (ClinicalTrials.gov: NCT03073772) was to investigate the long-term effects of 12 weeks cognitive or aerobic training on cognitive function, psychological health, and work ability for patients diagnosed with exhaustion disorder (ED)...
April 25, 2018: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/29692285/metacognitive-reflection-and-insight-therapy-merit-for-patients-with-schizophrenia
#20
S de Jong, R J M van Donkersgoed, M E Timmerman, M Aan Het Rot, L Wunderink, J Arends, M van Der Gaag, A Aleman, P H Lysaker, G H M Pijnenborg
BACKGROUND: Impaired metacognition is associated with difficulties in the daily functioning of people with psychosis. Metacognition can be divided into four domains: Self-Reflection, Understanding the Other's Mind, Decentration, and Mastery. This study investigated whether Metacognitive Reflection and Insight Therapy (MERIT) can be used to improve metacognition. METHODS: This study is a randomized controlled trial. Patients in the active condition (n = 35) received forty MERIT sessions, the control group (n = 35) received treatment as usual...
April 25, 2018: Psychological Medicine
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