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Depression and work impairement

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https://www.readbyqxmd.com/read/28735060/individual-roles-of-brain-and-serum-alcohol-dehydrogenase-isoforms-in-regulation-of-alcohol-consumption-in-spf-wistar-rats
#1
Vsevolod V Pavshintsev, Nikita A Mitkin, Olga Y Frolova, Ekaterina A Kushnir, Olga A Averina, Maxim L Lovat
Alcohol dehydrogenases (ADH) are key enzymes of ethanol metabolism that mediate its oxidation to acetaldehyde. ADHs are also able to oxidize some types of neurotransmitters such as dopamine, serotonin and norepinephrine. Increased level of ADHs activity, induced by chronic alcohol consumption, is presumably associated with disturbed neurotransmitters metabolism that leads to stable alcohol craving. As earlier reported, intraperitoneal administration of 4-methilpirasole (non-specific inhibitor of ADHs) has shown to provide a short-term anti-alcoholic effect, but individual roles of ADH isoforms in this process were still unclear...
July 19, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28731445/colivelin-ameliorates-impairments-in%C3%A2-cognitive-behaviors-and-synaptic-plasticity-in-app-ps1-transgenic-mice
#2
Meina Wu, Hui Shi, Yexin He, Li Yuan, Xuesong Qu, Jun Zhang, Zhaojun Wang, Hongyan Cai, Jinshun Qi
Alzheimer's disease (AD) is the most common cause of dementia, and effective therapeutics are lacking. Colivelin (CLN), a novel, strong humanin derivative, is effective in vitro in preventing cell death induced by AD-causative genes and amyloid-β protein (Aβ) even at a low concentration. We recently demonstrated that intrahippocampal injection of CLN prevents Aβ25-35-induced deficits in spatial memory and synaptic plasticity in normal rats. Here, we further observed the effects of chronically intranasally (i...
July 19, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28727115/the-microbiota-gut-brain-axis-as-a-key-regulator-of-neural-function-and-the-stress-response-implications-for-human-and-animal-health
#3
N C Wiley, T G Dinan, R P Ross, C Stanton, G Clarke, J F Cryan
The brain-gut-microbiota axis comprises an extensive communication network between the brain, the gut, and the microbiota residing there. Development of a diverse gut microbiota is vital for multiple features of behavior and physiology, as well as many fundamental aspects of brain structure and function. Appropriate early-life assembly of the gut microbiota is also believed to play a role in subsequent emotional and cognitive development. If the composition, diversity, or assembly of the gut microbiota is impaired, this impairment can have a negative impact on host health and lead to disorders such as obesity, diabetes, inflammatory diseases, and even potentially neuropsychiatric illnesses, including anxiety and depression...
July 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28726513/effects-of-depression-and-past-year-binge-drinking-on-cognitive-control-processes-during-a-flanker-task-in-college-aged-adults
#4
Arin M Connell, Sarah Danzo, Glen Dawson
BACKGROUND: Recent but largely separate literatures have examined neurocognitive alterations related to both depression and binge drinking, suggesting similar patterns of impairments in attention control and decisional processes. However, depression and problematic alcohol use tend to co-occur, and few studies have examined whether cognitive processing effects of depression and binge drinking are independent or interacting. OBJECTIVE: The current study examined joint effects of depressive symptoms and past-year binge drinking on cognitive processing (measured via EEG assessment)...
July 20, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28722100/-tailored-care-for-functional-vertigo-dizziness-an-integrative-group-psychotherapy-approach
#5
Katharina Radziej, Gabriele Schmid-Mühlbauer, Karina Limburg, Claas Lahmann
Functional vertigo and dizziness (VD) symptoms are highly prevalent and usually accompanied by a strong impairment of quality in everyday and working life. The complaints are often associated with various psychiatric disorders, particularly phobic and other anxiety disorders, depressive or somatoform disorders. Despite this clinical relevance of VD symptoms, studies towards psychotherapeutic treatment options for patients with functional VD are still rare. Thus, the present study outlines a manual for outpatient group therapy for patients with functional VD symptoms...
June 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/28720169/characteristics-of-healthy-older-adults-that-influence-self-rated-cognitive-function
#6
Bryce P Mulligan, Colette M Smart, Sidney J Segalowitz, Stuart W S MacDonald
OBJECTIVES: We sought to clarify the nature of self-reported cognitive function among healthy older adults by considering the short-term, within-person association (coupling) of subjective cognitive function with objective cognitive performance. We expected this within-person coupling to differ between persons as a function of self-perceived global cognitive decline and depression, anxiety, or neuroticism. METHODS: This was an intensive measurement (short-term longitudinal) study of 29 older adult volunteers between the ages of 65 and 80 years without an existing diagnosis of dementia or mild cognitive impairment...
July 19, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28718346/effect-of-desvenlafaxine-50-mg-and-100-mg-on-energy-and-lassitude-in-patients-with-major-depressive-disorder-a-pooled-analysis
#7
Raymond W Lam, Dalia B Wajsbrot, Ellen Meier, Elizabeth Pappadopulos, Joan A Mackell, Matthieu Boucher
Nine randomized, double-blind, placebo-controlled studies of major depressive disorder were pooled to evaluate the effects of desvenlafaxine 50- and 100-mg/d on energy and lassitude in adults with major depressive disorder ( n=4279). Changes from baseline to endpoint in 17-item Hamilton Rating Scale for Depression (HAM-D17) Work and Activities, Retardation, and Somatic Symptoms General items, HAM-D17 psychomotor retardation factor, and Montgomery-Åsberg Depression Rating Scale Lassitude item were analyzed with a mixed model for repeated measures analysis of variance...
July 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28710824/a-novel-study-on-association-between-untreated-hearing-loss-and-cognitive-functions-of-older-adults-baseline-non-verbal-cognitive-assessment-results
#8
Dona M P Jayakody, Peter L Friedland, Robert H Eielboom, Ralph N Martins, Hamid R Sohrabi
BACKGROUND: Age-related hearing loss (ARHL) is highly prevalent in older adults and more than two-thirds above age 70 years suffer from ARHL. Recent studies have established a link between ARHL and cognitive impairment, however, most of the studies have used verbally loaded cognitive measures to investigate the association between ARHL and cognition. It is possible that due to hearing impairment, the elderly may experience difficulty in following verbal instructions or completing tasks that heavily rely on hearing during cognitive assessments...
July 15, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28691604/parent-psychopathology-and-neurocognitive-functioning-in-children-with-adhd
#9
Sharifah Shameem Agha, Stanley Zammit, Anita Thapar, Kate Langley
OBJECTIVE: The objective of this study was to examine the association between parent mental health (ADHD and depression) and offspring performance on neurocognitive tasks in children with ADHD. METHOD: The clinical sample consisted of 570 children (85% males, mean age: 10.77 years) with ADHD who completed neurocognitive tasks measuring working memory, attention set-shifting, and motivational deficits. Questionnaire measures were used to assess ADHD and depression symptom presence in parents...
July 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28687311/selective-changes-in-locomotor-activity-in-mice-due-to-low-intensity-microwaves-amplitude-modulated-in-the-eeg-spectral-domain
#10
Vincent Van Eeghem, Anissa El Arfani, Arta Anthoula, Laura Walrave, Ali Pourkazemi, Eduard Bentea, Thomas Demuyser, Ilse Smolders, Johan Stiens
Despite the numerous benefits of microwave applications in our daily life, microwaves were associated with diverse neurological complaints such as headaches and impaired sleep patterns, and changes in the electroencephalogram (EEG). To which extent microwaves influence the brain function remains unclear. This exploratory study assessed the behavior and neurochemistry in mice immediately or 4 weeks after a 6-day exposure to low-intensity 10 GHz microwaves with an amplitude modulation (AM) of 2 or 8 Hz. These modulation frequencies of 2 and 8 Hz are situated within the delta and theta-alpha frequency bands in the EEG spectrum and are associated with sleep and active behavior, respectively...
July 4, 2017: Neuroscience
https://www.readbyqxmd.com/read/28686082/providing-dementia-consultations-to-veterans-using-clinical-video-telehealth-results-from-a-clinical-demonstration-project
#11
Stuti Dang, Carlos A Gomez-Orozco, Maria H van Zuilen, Silvina Levis
PURPOSE: Veterans with dementia and their caregivers in remote areas may not have access to specialists to provide diagnosis, treatment, and education. The purpose of this clinical demonstration project was to examine the feasibility, acceptability, and impact of a video consultations clinic for veterans with dementia or memory complaints and their caregivers. METHODS: The dementia clinical video telehealth (CVT) consultation clinic was established to identify, diagnose, and treat dementia in veterans at sites distant from the main medical center...
July 7, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28681715/motor-cortex-trns-improves-pain-affective-and-cognitive-impairment-in-patients-with-fibromyalgia-preliminary-results-of-a-randomised-sham-controlled-trial
#12
Massimiliano Curatolo, Giuseppe La Bianca, Giuseppe Cosentino, Roberta Baschi, Giuseppe Salemi, Rossella Talotta, Marcello Romano, Giovanni Triolo, Marina De Tommaso, Brigida Fierro, Filippo Brighina
OBJECTIVES: Fibromyalgia (FM) is a clinical syndrome characterised by widespread musculoskeletal pain, chronic fatigue, cognitive deficits, and sleep and mood disorders. The effectiveness of most pharmacological treatments is limited, and there is a need for new, effective and well-tolerated therapies. It has recently been shown that transcranial direct-current stimulation (tDCS) of the motor cortex reduces pain, and that tDCS of the dorso-lateral prefrontal cortex (DLPFC) improves anxiety, depression and cognitive impairment in FM patients...
May 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28681505/the-work-and-social-adjustment-scale-psychometric-properties-and-validity-among-males-and-females-and-outpatients-with-and-without-personality-disorders
#13
G Pedersen, E H Kvarstein, T Wilberg
The Work and Social Adjustment Scale (WSAS) is an outcome measure assessing degree of functional impairment. Its psychometric properties, validity and sensitivity to change have been supported in several studies. However, no explicit psychometric or validity study of WSAS has been performed on data from a large sample of psychiatric outpatients, with and without personality disorders. The aim of this study was therefore to provide additional knowledge of the properties of WSAS in such a sample. The material comprised data from 1371 patients, from 15 different units participating in the Norwegian Network of Personality-Focused Treatment Programs...
July 5, 2017: Personality and Mental Health
https://www.readbyqxmd.com/read/28680036/behavioral-abnormalities-with-disruption-of-brain-structure-in-mice-overexpressing-vgf
#14
Takahiro Mizoguchi, Hiroko Minakuchi, Mitsue Ishisaka, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hideaki Hara
VGF nerve growth factor inducible (VGF) is a neuropeptide induced by nerve growth factor and brain-derived neurotrophic factor. This peptide is involved in synaptic plasticity, neurogenesis, and neurite growth in the brain. Patients with depression and bipolar disorder have lower-than-normal levels of VGF, whereas patients with schizophrenia and other cohorts of patients with depression have higher-than-normal levels. VGF knockout mice display behavioral abnormalities such as higher depressive behavior and memory dysfunction...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28668539/a-diet-low-in-fermentable-oligo-di-and-mono-saccharides-and-polyols-improves-quality-of-life-and-reduces-activity-impairment-in-patients-with-irritable-bowel-syndrome-and-diarrhea
#15
Shanti Eswaran, William D Chey, Kenya Jackson, Sivaram Pillai, Samuel W Chey, Theresa Han-Markey
BACKGROUND & AIMS: We investigated the effects of a diet low in fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) vs traditional dietary recommendations, on health-related quality of life (QOL), anxiety and depression, work productivity, and sleep quality in patients with IBS and diarrhea (IBS-D). METHODS: We conducted a prospective, single-center, single-blind trial of 92 adult patients with IBS-D (65 women; median age, 42.6 years) randomly assigned to groups placed on a diet low in FODMAPs or a modified diet recommended by the National Institute for Health and Care Excellence (mNICE) for 4 weeks...
June 28, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28667888/cognitive-impairment-as-measured-by-the-thinc-integrated-tool-thinc-it-association-with-psychosocial-function-in-major-depressive-disorder
#16
Danielle S Cha, Nicole E Carmona, Mehala Subramaniapillai, Rodrigo B Mansur, Yena Lee, Jae Hon Lee, JungGoo Lee, Joshua D Rosenblat, Margarita Shekotikhina, Caroline Park, Carola Rong, Tracy L Greer, Raymond Lam, Bernhard T Baune, John Harrison, Roger S McIntyre
BACKGROUND: Psychosocial impairment represents an important treatment target in major depressive disorder (MDD). The majority of patients with MDD do not regain premorbid levels of psychosocial functioning despite the resolution of core depressive symptoms. This study aimed to investigate the respective effects of cognitive function and depression severity on impaired psychosocial function in MDD. METHODS: Adults aged 18-65 with moderate-to-severe MDD (n = 100) and age-, sex-, and education-matched healthy controls participated in a cross-sectional study validating the THINC-integrated tool (THINC-it), a cognitive screening tool comprised of objective and subjective measures of cognitive function...
November 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28666826/affective-symptoms-in-schizophrenia-are-strongly-associated-with-neurocognitive-deficits-indicating-disorders-in-executive-functions-visual-memory-attention-and-social-cognition
#17
Buranee Kanchanatawan, Supaksorn Thika, George Anderson, Piotr Galecki, Michael Maes
The aim of this study was to assess the neurocognitive correlates of affective symptoms in schizophrenia. Towards this end, 40 healthy controls and 80 schizophrenia patients were investigated with six tests of the Cambridge Neuropsychological Test Automated Battery (CANTAB), assessing spatial working memory, paired-association learning, one touch stocking, rapid visual information (RVP), emotional recognition test and intra/extradimensional set shifting. The Hamilton Depression (HDRS) and Anxiety (HAMA) Rating Scales and the Calgary Depression Scale for Schizophrenia (CDSS) as well as the Positive and Negative Syndrome Scale (PANSS) were also used...
June 27, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28662478/disassociation-of-cognitive-and-affective-aspects-of-theory-of-mind-in-obsessive-compulsive-disorder
#18
Wanting Liu, Jie Fan, Jun Gan, Hui Lei, Chaoyang Niu, Raymond C K Chan, Xiongzhao Zhu
Impairment in social functioning has been widely described in obsessive-compulsive disorder (OCD). However, several aspects of social cognition, such as theory of mind (ToM), have not been substantially investigated in this context. This study examined cognitive and affective ToM in 40 OCD patients and 38 age-, sex-, and education-matched healthy controls (HCs) with the computerized Yoni task and a battery of neurocognitive tests. OCD symptom severity was assessed with the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS)...
June 20, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28658973/the-relation-between-physical-activity-and-cognitive-change-in-older-latinos
#19
Shannon Halloway, JoEllen Wilbur, Michael E Schoeny, Lisa L Barnes
Cognitive impairment in older Latinos is of concern due to the rapid growth of this population and their increased risk for dementia due to chronic disease. Evidence, primarily from studies of non-Latino Whites, suggests that physical activity (PA) may reduce cognitive decline. Few longitudinal studies have included older Latinos, objective measures of PA, or neurocognitive tests that assess domains of cognition. The purpose of this longitudinal study was to explore the relationship between changes in PA and cognitive decline in older Latinos over an average of 5 years...
January 1, 2017: Biological Research for Nursing
https://www.readbyqxmd.com/read/28656885/social-cognition-abilities-in-patients-with-different-multiple-sclerosis-subtypes
#20
Audrey Henry, Ayman Tourbah, Marie-Pierre Chaunu, Serge Bakchine, Michèle Montreuil
OBJECTIVES: Multiple sclerosis (MS) can be associated with impaired social cognition. However, social cognition skills have never been explored in the different subtypes of MS. The first aim of this study was to examine whether MS subtypes differ on the course of social cognition. The second aim was to explore the relationship between social cognition performances and executive abilities and mood variables. METHODS: Sixty-two patients with MS and 33 healthy matched controls performed experimental tasks assessing facial emotion recognition, theory of mind (ToM), and cognitive functioning, in particular executive functions...
June 28, 2017: Journal of the International Neuropsychological Society: JINS
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