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Depression and work impairement

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https://www.readbyqxmd.com/read/28548708/glucocerebrosidase-mutations-and-neuropsychiatric-phenotypes-in-parkinson-s-disease-and-lewy-body-dementias-review-and-meta-analyses
#1
REVIEW
Byron Creese, Emily Bell, Iskandar Johar, Paul Francis, Clive Ballard, Dag Aarsland
Heterozygous mutations in glucocerebrosidase gene (GBA) are a major genetic risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Recently, there has been a considerable focus on the relationship between GBA mutations and emergence of cognitive impairment and neuropsychiatric symptoms in these diseases. Here, we review the literature in this area, with a particular focus, including meta-analysis, on the key neuropsychiatric symptoms of cognitive impairment, psychosis, and depression in Parkinson's disease...
May 26, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28545013/level-of-functioning-perceived-work-ability-and-work-status-among-psychiatric-patients-with-major-mental-disorders
#2
B Karpov, G Joffe, K Aaltonen, J Suvisaari, I Baryshnikov, P Näätänen, M Koivisto, T Melartin, J Oksanen, K Suominen, M Heikkinen, E Isometsä
BACKGROUND: Major mental disorders are highly disabling conditions that result in substantial socioeconomic burden. Subjective and objective measures of functioning or ability to work, their concordance, or risk factors for them may differ between disorders. METHODS: Self-reported level of functioning, perceived work ability, and current work status were evaluated among psychiatric care patients with schizophrenia or schizoaffective disorder (SSA, n=113), bipolar disorder (BD, n=99), or depressive disorder (DD, n=188) within the Helsinki University Psychiatric Consortium Study...
April 7, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28541754/overgeneral-autobiographical-memory-and-depression-in-older-adults-a-systematic-review
#3
F C L Wilson, J D Gregory
OBJECTIVES: Overgeneral autobiographical memory (OGM) is a well-researched phenomenon in working age adults with depression. However, the relevance and importance of OGM in older adult depression is not well established. The aim of this review was to synthesise existing literature on OGM and depressive symptoms in older adults under the framework of the Capture and Rumination, Functional Avoidance and Impaired Executive Control (CaR-FA-X) model. Is there an alternative to this as I thought references in abstracts were permissable under APA? METHOD: Literature searches were conducted using PsychINFO, PubMed and Web of Knowledge...
May 25, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28534643/bicams-in-the-argentine-population-relationship-with-clinical-and-sociodemographic-variables
#4
Sandra Vanotti, A Smerbeck, María B Eizaguirre, Maria L Saladino, Ralph R H Benedict, Fernando J Caceres
The Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) was developed to provide valid assessment of cognitive impairment in multiple sclerosis (MS). The relationship between clinical and social variables and cognitive disorders has been extensively studied, but primarily in developed countries with a focus on other cognitive measures or batteries. The objectives of this study were to analyze the relationship between the BICAMS data and key clinical and sociodemographic variables in the Argentine MS population...
May 23, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28529071/exogenous-fgf2-reverses-depressive-like-behaviors-and-restores-the-suppressed-fgf2-erk1-2-signaling-and-the-impaired-hippocampal-neurogenesis-induced-by-neuroinflammation
#5
Ming-Ming Tang, Wen-Juan Lin, Jun-Tao Zhang, Ya-Wei Zhao, Ying-Cong Li
Our previous work demonstrated that neuroinflammation evoked by triple repeated central LPS challenges inhibited adult hippocampal neurogenesis that were correlated with the depressive-like behavioral symptoms induced by neuroinflammation. These findings suggest that hippocampal neurogenesis might be one of biological mechanisms underlying depression induced by neuroinflammation and targeting neurogenesis might lead to new therapeutic strategies for the treatment of depression. In this study, we manipulated adult hippocampal neurogenesis using fibroblast growth factor 2 (FGF2), one crucial molecule modulating cell proliferation and survival in central nervous system, and investigate the involvement and the potential therapeutic effects of FGF2 on neuroinflammation-induced depression...
May 18, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28522892/enhancing-communication-in-adults-with-dementia-and-age-related-hearing-loss
#6
REVIEW
Sara K Mamo, Esther Oh, Frank R Lin
For many adults with dementia, age-related hearing loss is undiagnosed and/or untreated. Untreated hearing loss can exacerbate common dementia-related behavioral symptoms, such as depression, apathy, agitation. Despite the potential benefits to the individual and the family, pursuing and adopting hearing aids for persons with dementia presents with many challenges. As such, this group of vulnerable older adults is well suited for alternative approaches that adopt an interventional audiology framework. This article reviews alternative hearing care models that we have tested when working with older adults with cognitive impairments...
May 2017: Seminars in Hearing
https://www.readbyqxmd.com/read/28516509/the-incidence-and-predictors-of-depressive-and-anxiety-symptoms-in-older-adults-with-vision-impairment-a-longitudinal-prospective-cohort-study
#7
Thomas J Heesterbeek, Hilde P A van der Aa, Ger H M B van Rens, Johannes W R Twisk, Ruth M A van Nispen
PURPOSE: Depression and anxiety are highly prevalent in older adults with vision impairment. Because symptoms of depression and anxiety appear to fluctuate, it is important to identify patients who are at risk of developing these symptoms for early diagnosis and treatment. Therefore, the aim of this study was to determine the incidence of subthreshold depression and anxiety, and to investigate predictors of developing symptoms of depression and anxiety in older adults with vision impairment who had no subthreshold depression or anxiety at baseline...
May 18, 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/28509343/the-influence-of-vascular-risk-factors-on-cognitive-function-in-early-parkinson-s-disease
#8
Maxime Doiron, Mélanie Langlois, Nicolas Dupré, Martine Simard
OBJECTIVES: Hypertension, dyslipidemia, diabetes, and obesity are well-established risk factors for cognitive impairment and dementia in older adults. In contrast, previous studies that have assessed the impact of vascular risk factors (VRFs) on cognition in Parkinson's disease (PD) have had methodological limitations and reported conflicting findings. We address this question in a large well-characterized cohort of de novo PD patients. METHODS: A total of 367 untreated and non-demented patients aged 50 years and older with early PD (H&Y = 1...
May 16, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28507528/cognitive-impairments-in-occupational-burnout-error-processing-and-its-indices-of-reactive-and-proactive-control
#9
Krystyna Golonka, Justyna Mojsa-Kaja, Magda Gawlowska, Katarzyna Popiel
The presented study refers to cognitive aspects of burnout as the effects of long-term work-related stress. The purpose of the study was to investigate electrophysiological correlates of burnout to explain the mechanisms of the core burnout symptoms: exhaustion and depersonalization/cynicism. The analyzed error-related electrophysiological markers shed light on impaired cognitive mechanisms and the specific changes in information-processing in burnout. In the EEG study design (N = 80), two components of error-related potential (ERP), error-related negativity (ERN), and error positivity (Pe), were analyzed...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28504307/family-based-promotion-of-mental-health-in-children-affected-by-hiv-a-pilot-randomized-controlled-trial
#10
Theresa S Betancourt, Lauren C Ng, Catherine M Kirk, Robert T Brennan, William R Beardslee, Sara Stulac, Christine Mushashi, Estella Nduwimana, Sylvere Mukunzi, Beatha Nyirandagijimana, Godfrey Kalisa, Cyamatare F Rwabukwisi, Vincent Sezibera
BACKGROUND: Children affected by HIV are at risk for poor mental health. We conducted a pilot randomized controlled trial (RCT) of the Family Strengthening Intervention (FSI-HIV), a family home-visiting intervention to promote mental health and improve parent-child relationships in families with caregivers living with HIV, hypothesizing that child and family outcomes would be superior to usual care social work services. METHODS: Eighty two families (N = 170 children, 48...
May 15, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28499084/psychological-assessment-of-emirati-patients-pursuing-bariatric-surgery-for-obesity
#11
Ossama T Osman, Essam Emam, Taoufik Zoubeidi, Fadwa Al-Mugaddam, Abdul-Kader Souid
Background: Obesity is currently a rapidly growing global problem of epidemic proportions and is especially prevalent in economically developed countries such as the United Arab Emirates. Obese individuals are increasingly considering bariatric surgery as their preferred means of choice for the reduction of excess body fat. This study explored the psychological characteristics that may potentially complicate the surgical management of obesity. Methods: This was a cross-sectional study of Emirati patients attending a bariatric clinic at Tawam Hospital, Al Ain, United Arab Emirates, between December 2010 and February 2012...
May 11, 2017: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/28496354/factors-associated-with-prescription-opioid-misuse-in-a-cross-sectional-cohort-of-patients-with-chronic-non-cancer-pain
#12
Jennifer M Hah, John A Sturgeon, Jennifer Zocca, Yasamin Sharifzadeh, Sean C Mackey
OBJECTIVE: To examine demographic features, psychosocial characteristics, pain-specific behavioral factors, substance abuse history, sleep, and indicators of overall physical function as predictors of opioid misuse in patients presenting for new patient evaluation at a tertiary pain clinic. METHODS: Overall, 625 patients with chronic non-cancer pain prospectively completed the Collaborative Health Outcomes Information Registry, assessing pain catastrophizing, National Institutes of Health Patient-Reported Outcomes Measurement Information System standardized measures (pain intensity, pain behavior, pain interference, physical function, sleep disturbance, sleep-related impairment, anger, depression, anxiety, and fatigue), and substance use history...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28493898/apathy-but-not-depression-is-associated-with-executive-dysfunction-in-cerebral-small-vessel-disease
#13
Valerie Lohner, Rebecca L Brookes, Matthew J Hollocks, Robin G Morris, Hugh S Markus
OBJECTIVE: To determine the prevalence of apathy and depression in cerebral small vessel disease (SVD), and the relationships between both apathy and depression with cognition. To examine whether apathy is specifically related to impairment in executive functioning and processing speed. METHODS: 196 patients with a clinical lacunar stroke and an anatomically corresponding lacunar infarct on MRI were compared to 300 stroke-free controls. Apathy and depression were measured using the Geriatric Depression Scale, and cognitive functioning was assessed using an SVD cognitive screening tool, the Brief Memory and Executive Test, which measures executive functioning/processing speed and memory/orientation...
2017: PloS One
https://www.readbyqxmd.com/read/28493605/adverse-effects-of-obesity-on-cognitive-functions-in-individuals-at-ultra-high-risk-for-bipolar-disorder-results-from-the-global-mood-and-brain-science-initiative
#14
Roger S McIntyre, Rodrigo B Mansur, Yena Lee, Letícia Japiassú, Kun Chen, Rui Lu, Weicong Lu, Xiaodong Chen, Ting Li, Guiyun Xu, Kangguang Lin
BACKGROUND: The burden of illness associated with bipolar disorder (BD) warrants early pre-emption/prevention. Prediction models limited to psychiatric phenomenology have insufficient predictive power. Herein, we aimed to evaluate whether the presence of overweight/obesity is associated with greater cognitive decline in individuals at high risk (HR) or ultra high risk (UHR) for BD. METHODS: We conducted a retrospective analysis to investigate the moderational role of body mass index (BMI) on measures of cognitive function...
March 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28492772/life-and-health-conditions-among-elderly-results-of-the-epifloripa-idoso-cohort-study
#15
Susana Cararo Confortin, Ione Jayce Ceola Schneider, Danielle Ledur Antes, Francieli Cembranel, Lariane Mortean Ono, Larissa Pruner Marques, Lucélia Justino Borges, Rodrigo de Rosso Krug, Eleonora d'Orsi
OBJECTIVE: to identify sociodemographic, behavioral and health changes in a follow-up of participants in the health survey EpiFloripa Idoso. METHODS: this is a population-based longitudinal study with elderly individuals in Florianópolis-SC, Brazil. RESULTS: 1,702 elderly individuals were interviewed in 2009-2010 and 1,197 in 2013-2014 (response rate: 89.1% and 70.2%, respectively); among followed-up individuals, most of them remained with a partner (53...
April 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/28482757/n-3-polyunsaturated-fatty-acid-supplementation-restored-impaired-memory-and-gabaergic-synaptic-efficacy-in-the-hippocampus-of-stressed-rats
#16
Miguel Ángel Pérez, Valentín Peñaloza-Sancho, Juan Ahumada, Marco Fuenzalida, Alexies Dagnino-Subiabre
While chronic stress induces dendritic atrophy in the hippocampus and impairs learning and memory, supplementation with n-3 polyunsaturated fatty acids (n-3 PUFA) is known to improve learning and memory of control rats. Whether n-3 PUFA supplementation improves dendritic morphology, synaptic transmission, and memory of chronically stressed rats remains unknown. In this work, we randomly assigned male Sprague-Dawley rats in four experimental groups: two unsupplemented groups, control and stress, and two supplemented groups with n-3 PUFA (DHA and EPA mix), control + n-3 PUFA and stress + n-3 PUFA...
May 8, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28482212/the-frequency-and-influence-of-dementia-risk-factors-in-prodromal-alzheimer-s-disease
#17
Isabelle Bos, Stephanie J Vos, Lutz Frölich, Johannes Kornhuber, Jens Wiltfang, Wolfgang Maier, Oliver Peters, Eckhart Rüther, Sebastiaan Engelborghs, Ellis Niemantsverdriet, Ellen Elisa De Roeck, Magda Tsolaki, Yvonne Freund-Levi, Peter Johannsen, Rik Vandenberghe, Alberto Lleó, Daniel Alcolea, Giovanni B Frisoni, Samantha Galluzzi, Flavio Nobili, Silvia Morbelli, Alexander Drzezga, Mira Didic, Bart N van Berckel, Eric Salmon, Christine Bastin, Solene Dauby, Isabel Santana, Inês Baldeiras, Alexandre de Mendonça, Dina Silva, Anders Wallin, Arto Nordlund, Preciosa M Coloma, Angelika Wientzek, Myriam Alexander, Gerald P Novak, Mark Forrest Gordon, Åsa K Wallin, Harald Hampel, Hilkka Soininen, Sanna-Kaisa Herukka, Philip Scheltens, Frans R Verhey, Pieter Jelle Visser
We investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive impairment from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of 10 risk factors between the subgroups, and used Cox-regression to examine the effect of risk factors on cognitive decline...
April 8, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28476208/transcriptome-alterations-in-prefrontal-pyramidal-cells-distinguish-schizophrenia-from-bipolar-and-major-depressive-disorders
#18
Dominique Arion, Zhiguang Huo, John F Enwright, John P Corradi, George Tseng, David A Lewis
BACKGROUND: Impairments in certain cognitive processes (e.g., working memory) are typically most pronounced in schizophrenia (SZ), intermediate in bipolar disorder, and least in major depressive disorder. Given that working memory depends, in part, on neural circuitry that includes pyramidal cells in layer 3 (L3) and layer 5 (L5) of the dorsolateral prefrontal cortex (DLPFC), we sought to determine if transcriptome alterations in these neurons were shared or distinctive for each diagnosis...
April 4, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28471926/a-literature-review-of-psychosocial-comorbidities-related-to-working-capacity-after-aneurysmal-subarachnoid-hemorrhage
#19
Eleanor Turi, Yvette Conley, Ansley Grimes Stanfill
OBJECTIVE: The aim of this study was to describe literature regarding the impact of psychosocial comorbidities on working capacity after aneurysmal subarachnoid hemorrhage (aSAH). DESIGN/METHODS: This study is a review of the literature using PubMed, CINAHL, PyschINFO, and Google Scholar. RESULTS: Patients with aSAH affected by depression, anxiety, cognitive impairment, or posttraumatic stress disorder are less likely to return to work, although there are mixed results...
June 2017: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/28471243/utility-of-providing-a-concussion-definition-in-the-assessment-of-concussion-history-in-former-nfl-players
#20
Michael L Alosco, Johnny Jarnagin, Yorghos Tripodis, Brett Martin, Christine Chaisson, Christine M Baugh, Alcy Torres, Christopher J Nowinski, Robert C Cantu, Robert A Stern
OBJECTIVE: Former National Football League (NFL) players' working knowledge of concussion has not yet been evaluated, despite this population being a major clinical research target due to the association between repetitive head impacts (RHI) and long-term clinical impairments. This study examined former NFL players' understanding of the current concussion definition, and the association between number of concussions with clinical function. METHODS: 95 former NFL players (mean age = 55...
May 4, 2017: Brain Injury: [BI]
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