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Depression and work impairement

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https://www.readbyqxmd.com/read/28078566/an-eye-tracking-controlled-neuropsychological-battery-for-cognitive-assessment-in-neurological-diseases
#1
Barbara Poletti, Laura Carelli, Federica Solca, Annalisa Lafronza, Elisa Pedroli, Andrea Faini, Stefano Zago, Nicola Ticozzi, Andrea Ciammola, Claudia Morelli, Paolo Meriggi, Pietro Cipresso, Dorothée Lulé, Albert C Ludolph, Giuseppe Riva, Vincenzo Silani
Traditional cognitive assessment in neurological conditions involving physical disability is often prevented by the presence of verbal-motor impairment; to date, an extensive motor-verbal-free neuropsychological battery is not available for such purposes. We adapted a set of neuropsychological tests, assessing language, attentional abilities, executive functions and social cognition, for eye-tracking (ET) control, and explored its feasibility in a sample of healthy participants. Thirty healthy subjects performed a neuropsychological assessment, using an ET-based neuropsychological battery, together with standard "paper and pencil" cognitive measures for frontal (Frontal Assessment Battery-FAB) and working memory abilities (Digit Sequencing Task) and for global cognitive efficiency (Montreal Cognitive Assessment-MoCA)...
January 11, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28068553/the-relationship-of-community-activities-with-cognitive-impairment-and-depressive-mood-independent-of-mobility-disorder-in-japanese-older-adults
#2
Mika Okura, Mihoko Ogita, Miki Yamamoto, Toshimi Nakai, Tomoko Numata, Hidenori Arai
AIM: This study aimed to examine the relationship of participating in community activities (CA) with cognitive impairment and depressive mood independent of mobility disorder (MD) among older Japanese people. METHODS: Elderly residents in institutions or those requiring long-term care insurance services were excluded; questionnaires were mailed to 5401 older adults in 2013. The response rate was 94.3% (n=5094). We used multiple imputation to manage missing data...
December 29, 2016: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28065388/a-systematic-review-of-cognitive-function-and-psychosocial-well-being-in-school-age-children-with-narcolepsy
#3
REVIEW
Jane E Blackwell, Hetaf A Alammar, Anna R Weighall, Ian Kellar, Hannah M Nash
In August 2010, concerns were raised about an increase in the incidence rate of narcolepsy diagnosis in children and adolescents. Narcolepsy is a chronic neurological sleep disorder characterised by excessive daytime sleepiness and attacks of muscle weakness which are often precipitated by strong emotions, known as cataplexy. We systematically examined and updated the scientific literature on the consequences of narcolepsy on cognitive function and psychosocial well-being in school-age children. Eight studies published between 2005 and 2015 were eligible for inclusion in this review...
July 18, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/28064113/cognitive-control-dysfunction-in-emotion-dysregulation-and-psychopathology-of-major-depression-md-evidence-from-transcranial-brain-stimulation-of-the-dorsolateral-prefrontal-cortex-dlpfc
#4
Mohammad Ali Salehinejad, Elham Ghanavai, Reza Rostami, Vahid Nejati
BACKGROUND: Previous studies showed that MD is associated with a variety of cognitive deficits and executive dysfunctions which can persist even in remitted states. However, the role of cognitive impairments in MD psychopathology and treatment is not fully understood. This article aims to discuss how executive functions central components (e.g., Working memory and attention) mediate MD psychopathology considering the role of dorsolateral prefrontal cortex (dLPFC) and present findings of a brain stimulation experiment to support this notion...
December 31, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28060527/moderating-effect-of-intrinsic-religiosity-on-the-relationship-between-depression-and-cognitive-function-among-community-dwelling-older-adults
#5
Hui Foh Foong, Tengku Aizan Hamid, Rahimah Ibrahim, Sharifah Azizah Haron
OBJECTIVES: Research has found that depression in later life is associated with cognitive impairment. Thus, the mechanism to reduce the effect of depression on cognitive function is warranted. In this paper, we intend to examine whether intrinsic religiosity mediates the association between depression and cognitive function. METHOD: The study included 2322 nationally representative community-dwelling elderly in Malaysia, randomly selected through a multi-stage proportional cluster random sampling from Peninsular Malaysia...
January 6, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28059839/the-symptom-experience-of-patients-with-advanced-pancreatic-cancer-an-integrative-review
#6
Chia-Chun Tang, Diane Von Ah, Janet S Fulton
BACKGROUND: Pancreatic cancer is a devastating disease with limited treatment options. More than 80% of pancreatic cancers are diagnosed in advanced stages and often have debilitating symptoms, making symptom management paramount, yet the symptom experience of patients with advanced pancreatic cancer (APC) is not well understood. OBJECTIVE: The purpose of this integrative review is to synthesize the current evidence regarding the symptom experience of patients with APC...
January 4, 2017: Cancer Nursing
https://www.readbyqxmd.com/read/28057878/pseudoautosomal-abnormalities-in-terminal-azfb-c-deletions-are-associated-with-isochromosomes-yp-and-may-lead-to-abnormal-growth-and-neuropsychiatric-function
#7
A Castro, F Rodríguez, M Flórez, P López, B Curotto, D Martínez, A Maturana, M C Lardone, C Palma, V Mericq, M Ebensperger, F Cassorla
STUDY QUESTION: Are copy number variations (CNVs) in the pseudoautosomal regions (PARs) frequent in subjects with Y-chromosome microdeletions and can they lead to abnormal stature and/or neuropsychiatric disorders? SUMMARY ANSWER: Only subjects diagnosed with azoospermia factor (AZF)b+c deletions spanning to the end of the Y chromosome (i.e. terminal deletions) harbor Y isochromosomes and/or cells 45,X that lead to pseudoautosomal gene CNVs, which were associated with abnormal stature and/or neuropsychiatric disorders...
January 5, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28057695/cancer-and-cognitive-function-the-path-through-life-project
#8
Sarang Kim, Nicolas Cherbuin, Kaarin J Anstey
BACKGROUND: A limited number of studies have shown that cancer diagnosis plays a protective role in Alzheimer's disease. However, the effect of the cancer diagnosis on general cognitive function/cognitive decline has not been previously examined. The aim of this study was to investigate the relationship between cancer diagnosis and cognitive function and mild cognitive impairment/disorders (MCI/MCD), adjusting for cancer treatments. METHODS: These data were drawn from the Personality and Total Health (PATH) Through Life Study, a population-based Australian cohort study...
January 4, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28052513/improving-late-life-depression-and-cognitive-control-through-the-use-of-therapeutic-video-game-technology-a-proof-of-concept-randomized-trial
#9
Joaquin A Anguera, Faith M Gunning, Patricia A Areán
BACKGROUND: Existing treatments for depression are known to have only modest effects, are insufficiently targeted, and are inconsistently utilized, particularly in older adults. Indeed, older adults with impaired cognitive control networks tend to demonstrate poor response to a majority of existing depression interventions. Cognitive control interventions delivered using entertainment software have the potential to not only target the underlying cerebral dysfunction associated with depression, but to do so in a manner that is engaging and engenders adherence to treatment protocol...
January 3, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28033564/neighborhood-age-structure-and-cognitive-function-in-a-nationally-representative-sample-of-older-adults-in-the-u-s
#10
Esther M Friedman, Regina A Shih, Mary E Slaughter, Margaret M Weden, Kathleen A Cagney
Recent evidence suggests that living in a neighborhood with a greater percentage of older adults is associated with better individual health, including lower depression, better self-rated health, and a decreased risk of overall mortality. However, much of the work to date suffers from four limitations. First, none of the U.S.-based studies examine the association at the national level. Second, no studies have examined three important hypothesized mechanisms - neighborhood socioeconomic status and neighborhood social and physical characteristics - which are significantly correlated with both neighborhood age structure and health...
December 5, 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/28018166/motor-dysfunctions-and-neuropathology-in-mouse-models-of-spinocerebellar-ataxia-type-2-a-comprehensive-review
#11
REVIEW
João M Da Conceição Alves-Cruzeiro, Liliana Mendonça, Luís Pereira de Almeida, Clévio Nóbrega
Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant ataxia caused by an expansion of CAG repeats in the exon 1 of the gene ATXN2, conferring a gain of toxic function that triggers the appearance of the disease phenotype. SCA2 is characterized by several symptoms including progressive gait ataxia and dysarthria, slow saccadic eye movements, sleep disturbances, cognitive impairments, and psychological dysfunctions such as insomnia and depression, among others. The available treatments rely on palliative care, which mitigate some of the major symptoms but ultimately fail to block the disease progression...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28012505/reversible-cognitive-frailty-dementia-and-all-cause-mortality-the-italian-longitudinal-study-on-aging
#12
Vincenzo Solfrizzi, Emanuele Scafato, Davide Seripa, Madia Lozupone, Bruno P Imbimbo, Angela D'Amato, Rosanna Tortelli, Andrea Schilardi, Lucia Galluzzo, Claudia Gandin, Marzia Baldereschi, Antonio Di Carlo, Domenico Inzitari, Antonio Daniele, Carlo Sabbà, Giancarlo Logroscino, Francesco Panza
OBJECTIVES: Cognitive frailty, a condition describing the simultaneous presence of physical frailty and mild cognitive impairment, has been recently defined by an international consensus group. We estimated the predictive role of a "reversible" cognitive frailty model on incident dementia, its subtypes, and all-cause mortality in nondemented older individuals. We verified if vascular risk factors or depressive symptoms could modify this predictive role. DESIGN: Longitudinal population-based study with 3...
January 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/27998026/determinants-of-patient-physician-discordance-in-global-assessment-in-psoriatic-arthritis-a-multicenter-european-study
#13
Carole Desthieux, Benjamin Granger, Andra Rodica Balanescu, Peter Balint, Jürgen Braun, Juan Canete, Turid Heiberg, Philip S Helliwell, Umut Kalyoncu, Tore K Kvien, Uta Kiltz, Dora Niedermayer, Kati Otsa, Rossana Scrivo, Josef Smolen, Tanja A Stamm, Douglas J Veale, Kurt de Vlam, Maarten de Wit, Laure Gossec
OBJECTIVE: Patient-physician discordance in global assessment of disease activity concerned one third of patients but what does it reflect? We aimed to assess patient-physician discordance in psoriatic arthritis (PsA) and patient-reported domains of health (physical and psychological) associated to discordance. METHODS: The PsAID (Psoriatic Arthritis Impact of Disease) cross-sectional multicenter European study of patients with PsA according to expert opinion was analysed...
December 20, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27996635/disengagement-from-tasks-as-a-function-of-cognitive-load-and-depressive-symptom-severity
#14
Christopher R Bowie, Melissa Milanovic, Tanya Tran, Sarah Cassidy
INTRODUCTION: Depression is associated with impairment in cognition and everyday functioning. Mechanisms of cognitive dysfunction in depression and the factors that influence strategic deployment of cognitive abilities in complex environments remain elusive. In this study we investigated whether depression symptom severity is associated with disengagement from a working memory task (Paced Auditory Serial Addition Task; PASAT) with parametric adjustment of task difficulty. METHODS: 235 participants completed the Beck Depression Inventory, low and high cognitive load conditions of the PASAT, and quality of life...
December 20, 2016: Cognitive Neuropsychiatry
https://www.readbyqxmd.com/read/27995842/maternal-depression-and-trajectories-of-child-internalizing-and-externalizing-problems-the-roles-of-child-decision-making-and-working-memory
#15
E Flouri, A Ruddy, E Midouhas
BACKGROUND: Maternal depression may affect the emotional/behavioural outcomes of children with normal neurocognitive functioning less severely than it does those without. To guide prevention and intervention efforts, research must specify which aspects of a child's cognitive functioning both moderate the effect of maternal depression and are amenable to change. Working memory and decision making may be amenable to change and are so far unexplored as moderators of this effect. METHOD: Our sample was 17 160 Millennium Cohort Study children...
December 20, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27995617/prevalence-of-alexithymia-in-patients-with-psoriasis-and-its-association-with-disease-burden-a-multicentre-observational-study
#16
F Sampogna, L Puig, P Spuls, G Girolomoni, M A Radtke, B Kirby, M Brunori, P Bergmans, P Smirnov, J Rundle, F Lavie, C Paul
BACKGROUND: Single-centre studies show that alexithymia, defined as difficulty in recognizing and describing emotions, is more prevalent among psoriasis patients than in the general population. However, its prevalence and the consequences of the association between alexithymia and psoriasis are unclear. OBJECTIVES: The primary objective of this study was to determine the prevalence of alexithymia, as defined by a score ≥61 in the 20-item Toronto Alexithymia Scale (TAS-20), in a large sample of patients who had plaque psoriasis for ≤10 years and were eligible for phototherapy or systemic treatment...
December 20, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27989970/neurocognitive-function-surrounding-the-resection-of-frontal-who-grade-i-meningiomas-a-prospective-matched-control-study
#17
Philipp Hendrix, Elisa Hans, Christoph J Griessenauer, Andreas Simgen, Joachim Oertel, Julia Karbach
OBJECTIVE: Patients suffering from intracranial meningiomas may suffer from neurocognitive dysfunctions in specific cognitive domains depending on tumor location and size. The literature on the cognitive function surrounding the resection of frontal meningiomas is sparse. METHODS: We performed a prospective matched-control study to investigate the cognitive performance of frontal meningioma patients undergoing resection. The neurocognitive status one week and two months post resection was compared to the preoperative status and to matched-controls...
October 27, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27977620/changes-of-quality-of-life-and-cognitive-function-in-individuals-with-internet-gaming-disorder-a-6-month-follow-up
#18
Jae-A Lim, Jun-Young Lee, Hee Yeon Jung, Bo Kyung Sohn, Sam-Wook Choi, Yeon Jin Kim, Dai-Jin Kim, Jung-Seok Choi
Internet gaming disorder (IGD) contributes to poor quality of life (QOL) and cognitive dysfunction and is increasingly recognized as a social problem in various countries. However, no evidence exists to determine whether QOL and cognitive dysfunction stabilize after appropriate management. The present study addressed improvement in QOL and cognitive functioning associated with changes in addiction symptoms following outpatient management for IGD. A total of 84 young males (IGD group: N = 44, mean age: 19...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27965671/neuron-microglia-interactions-in-mental-health-disorders-for-better-and-for-worse
#19
REVIEW
Eric S Wohleb
Persistent cognitive and behavioral symptoms that characterize many mental health disorders arise from impaired neuroplasticity in several key corticolimbic brain regions. Recent evidence suggests that reciprocal neuron-microglia interactions shape neuroplasticity during physiological conditions, implicating microglia in the neurobiology of mental health disorders. Neuron-microglia interactions are modulated by several molecular and cellular pathways, and dysregulation of these pathways often have neurobiological consequences, including aberrant neuronal responses and microglia activation...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27928386/current-perspectives-of-bioptic-driving-in-low-vision
#20
REVIEW
Robert Chun, Maria Cucuras, Walter M Jay
In this review, the authors discuss the current perspectives of spectacle-mounted telescopes (bioptics) used for driving among patients with vision impairments. The history, design, driving laws surrounding bioptic use, and developing programs in The Netherlands and Canada are discussed. Patients who have certain visual requirements and stable disease status may be eligible candidates to consider using a bioptic aid for driving. Given the high prevalence of depression among visually impaired patients, low vision specialists can work with neuro-ophthalmologists to maximise the independence and visual function of patients who have permanent vision impairments but capable of maintaining driving privileges...
April 2016: Neuro-ophthalmology
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