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https://www.readbyqxmd.com/read/29653186/constraint-induced-movement-therapy-improves-efficacy-of-task-specific-training-after-severe-cortical-stroke-depending-on-the-ipsilesional-corticospinal-projections
#1
Naohiko Okabe, Naoyuki Himi, Emi Nakamura-Maruyama, Norito Hayashi, Issei Sakamoto, Kazuhiko Narita, Toru Hasegawa, Osamu Miyamoto
Descending spinal pathways (corticospinal, rubrospinal, and reticulospinal) are believed to contribute to functional recovery resulting from rehabilitative training after stroke. However, the contribution of each pathway remains unclear. In the current study, we investigated rehabilitation-induced functional recovery and remodelling of the descending spinal pathways after severe cortical stroke in rats followed by 3 weeks of various rehabilitation [constraint-induced movement therapy (CIMT), skilled forelimb reaching, rotarod, and treadmill exercise]...
April 10, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29653118/acute-high-intensity-interval-exercise-induces-comparable-levels-of-circulating-cell-free-dna-and-interleukin-6-in-obese-and-normal-weight-individuals
#2
Peter J Ferrandi, Brandon G Fico, Michael Whitehurst, Michael C Zourdos, Fanchen Bao, Katelyn M Dodge, Alexandra A Rodriguez, Gabriel Pena, Chun-Jung Huang
AIMS: Obesity is associated with lipid aggregation in adipocytes and macrophage infiltration, leading to increased oxidative stress and inflammation. Increased cell-free DNA (cfDNA) concentrations have been observed in clinical conditions of systemic inflammation. While the beneficial effects of regular physical activity on the release of circulating cfDNA still remain unknown, acute intense exercise has been shown to increase inflammatory cytokines and cfDNA concentrations in normal-weight individuals...
April 10, 2018: Life Sciences
https://www.readbyqxmd.com/read/29651253/a-lactate-kinetics-method-for-assessing-the-maximal-lactate-steady-state-workload
#3
Gernot O Hering, Ewald M Hennig, Hartmut J Riehle, Jens Stepan
During a continuously increasing exercise workload (WL) a point will be reached at which arterial lactate accumulates rapidly. This so-called lactate threshold (LT) is associated with the maximal lactate steady state workload (MLSSW ), the highest WL, at which arterial lactate concentration [LA] does not change. However, the physiological range in which the LT and the MLSSW occur has not been demonstrated directly. We used minor WL variations in the MLSSW range to assess arterial lactate kinetics in 278 treadmill and 148 bicycle ergometer exercise tests...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29650708/outcomes-in-asymptomatic-severe-aortic-stenosis-with-preserved-ejection-fraction-undergoing-rest-and-treadmill-stress-echocardiography
#4
Chetan P Huded, Ahmad Masri, Kenya Kusunose, Andrew L Goodman, Richard A Grimm, A Marc Gillinov, Douglas R Johnston, L Leonardo Rodriguez, Zoran B Popovic, Lars G Svensson, Brian P Griffin, Milind Y Desai
BACKGROUND: In asymptomatic patients with severe aortic stenosis and preserved left ventricular ejection fraction, we sought to assess the incremental prognostic value of resting valvuloarterial impedence (Zva) and left ventricular global longitudinal strain (LV-GLS) to treadmill stress echocardiography. METHODS AND RESULTS: We studied 504 such patients (66±12 years, 78% men, 32% with coronary artery disease who underwent treadmill stress echocardiography between 2001 and 2012...
April 12, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29649707/specific-smartphone-usage-and-cognitive-performance-affect-gait-characteristics-during-free-living-and-treadmill-walking
#5
Daniel Niederer, Anke Bumann, Yvonne Mühlhauser, Mareike Schmitt, Katja Wess, Tobias Engeroff, Jan Wilke, Lutz Vogt, Winfried Banzer
BACKGROUND: Mobile phone tasks like texting, typing, and dialling during walking are known to impact gait characteristics. Beyond that, the effects of performing smartphone-typical actions like researching and taking self-portraits (selfie) on gait have not been investigated yet. RESEARCH QUESTION: We aimed to investigate the effects of smartphone usage on relevant gait characteristics and to reveal potential association of basic cognitive and walking plus smartphone dual-task abilities...
April 6, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29649706/quantitative-assessment-for-flexed-elbow-deformity-during-gait-following-botulinum-toxin-a-treatment
#6
Hiroki Tanikawa, Hitoshi Kagaya, Keisuke Inagaki, Yusuke Kotsuji, Keita Suzuki, Kenta Fujimura, Masahiko Mukaino, Satoshi Hirano, Eiichi Saitoh, Yoshikiyo Kanada
BACKGROUND: The effect of botulinum toxin A (BoNTA) injection on flexed-elbow deformity is usually evaluated using the Modified Ashworth Scale (MAS), but only with the muscle tone at rest. Some patients show the flexed-elbow deformity during gait despite low muscle tone at rest. OBJECTIVE: This study aimed to evaluate the effect of BoNTA injection on flexed-elbow deformity during gait using a three-dimensional motion analysis system. METHODS: Twenty stroke patients with spastic flexed-elbow deformity during gait received BoNTA injections into the upper limb muscles...
April 6, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29644961/high-intensity-exercise-induced-intestinal-damage-is-protected-by-fermented-milk-supplemented-with-whey-protein-probiotic-and-pomegranate-punica-granatum-l
#7
Fernanda M Chaves, Igor L Baptista, Fernando M Simabuco, Paula G F Quaresma, Fabiola L Pena, Rosangela M N Bezerra, Jose R Pauli, Diogo T da Cunha, Patricia L Campos-Ferraz, Adriane E C Antunes
Here we evaluated the effect of fermented milk supplemented with whey protein (approximately 80 % protein), probiotic (Bifidobacterium animalis subsp. lactis BB12) and pomegranate juice (Punica granatum L.) on the physical performance, intestinal motility and villi structure, inflammatory markers and intestinal microbiota of rats under high-intensity acute exercise. In all, twenty-four Wistar rats were separated into groups: control (Ctrl), supplemented (Supp), exercised (Exe) and exercised and supplemented (Exe+Supp)...
April 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29644889/comparing-exercise-responses-to-aerobic-plus-resistance-training-between-postmenopausal-breast-cancer-survivors-undergoing-aromatase-inhibitor-therapy-and-healthy-women
#8
Thais R S de Paulo, Kerri M Winters-Stone, Juliana Viezel, Fabricio E Rossi, Bruna L Aro, Ana Carolina A C Trindade, Jamile S Codogno, Ismael F Freitas Junior
BACKGROUND: The aim of this study was to explore whether postmenopausal breast cancer survivors undergoing aromatase inhibitor therapy differ from healthy postmenopausal women in their response to the same aerobic + resistance training. METHODS: The participants were separated into two groups: postmenopausal breast cancer survivors undergoing aromatase inhibitor therapy for an average of 20 months (18 women) and healthy postmenopausal women (24 women). We assessed aerobic capacity (predicted maximum oxygen uptake (VO2 max) and maximum running velocity test (Vmax)) through a walking test, upper and lower body muscle strength using an estimated one-repetition maximum test, and body composition by dual-energy X-ray absorptiometry at baseline and at three, six, and nine months, respectively...
April 12, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29643701/higher-ventricular-premature-complex-burden-is-associated-with-lower-systolic-blood-pressure-response
#9
Jing-Wei Kang, Wei-Hsiang Yang, Jia-En Chi, Wei-Ta Chen
Background: Ventricular premature complexes (VPCs) with a burden higher than 10% to 20% of total daily heart beats can cause VPC-induced cardiomyopathy. The systolic blood pressure response (SBPR) is the difference between the SBP during maximal exercise and rest. A low SBPR was recently identified to be a marker of cardiomyopathy. The aim of this manuscript was to clarify the association between VPC burden and SBPR. Methods: From January to December 2015, all patients with a VPC burden larger than 240 beats/day on Holter recordings and treadmill exercise tests were enrolled...
March 2018: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29642921/feasibility-of-robot-based-perturbed-balance-training-during-treadmill-walking-in-a-high-functioning-chronic-stroke-subject-a-case-control-study
#10
Zlatko Matjačić, Matjaž Zadravec, Andrej Olenšek
BACKGROUND: For stroke survivors, balance deficits that persist after the completion of the rehabilitation process lead to a significant risk of falls. We have recently developed a balance-assessment robot (BAR-TM) that enables assessment of balancing abilities during walking. The purpose of this study was to test feasibility of using the BAR-TM in an experimental perturbed-balance training program with a selected high-functioning stroke survivor. METHODS: A control and an individual with right-side chronic hemiparesis post-stroke were studied...
April 11, 2018: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29627967/supervised-exercise-therapy-versus-home-based-exercise-therapy-versus-walking-advice-for-intermittent-claudication
#11
REVIEW
David Hageman, Hugo Jp Fokkenrood, Lindy Nm Gommans, Marijn Ml van den Houten, Joep Aw Teijink
BACKGROUND: Although supervised exercise therapy (SET) provides significant symptomatic benefit for patients with intermittent claudication (IC), it remains an underutilized tool. Widespread implementation of SET is restricted by lack of facilities and funding. Structured home-based exercise therapy (HBET) with an observation component (e.g., exercise logbooks, pedometers) and just walking advice (WA) are alternatives to SET. This is the second update of a review first published in 2006...
April 6, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29627740/fatigability-and-functional-performance-among-older-adults-with-low-normal-ankle-brachial-index-cross-sectional-findings-from-the-baltimore-longitudinal-study-of-aging
#12
Pablo Martinez-Amezcua, Kunihiro Matsushita, Eleanor M Simonsick, Luigi Ferrucci, Jennifer A Schrack
BACKGROUND AND AIMS: Peripheral artery disease (PAD) is associated with poor mobility and fatigue, but the relationship between preclinical ankle-brachial index (ABI) and early markers of fatigue and functional decline has not been defined. METHODS: 570 adults, 50 and older, from the Baltimore Longitudinal Study of Aging (N = 570), with normal values of ABI (1-1.39), were classified into ABI tertiles. Perceived fatigability was assessed after a 5-min, treadmill walk (1...
March 22, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29627608/effect-of-wheelchair-stroke-pattern-on-upper-extremity-muscle-fatigue
#13
Brittany Bickelhaupt, Sakiko Oyama, Jonathan Benfield, Keith Burau, Shuko Lee, Michelle Trbovich
BACKGROUND: Shoulder dysfunction is common in persons with spinal cord injury (SCI) with an incidence of up to 63%1 . Dysfunction is a result of muscle imbalances, specifically denervated rotator cuff muscles that are repetitively used during manual wheelchair propulsion. OBJECTIVE: To determine which arm stroke technique, pump (P) or semicircular (SC), is most energy efficient for long periods of propulsion. DESIGN: A small randomized study with repeated-measures observations...
April 5, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29627499/pelvic-excursion-during-walking-post-stroke-a-novel-classification-system
#14
Virginia L Little, Theresa E McGuirk, Lindsay A Perry, Carolynn Patten
BACKGROUND: Researchers and clinicians often use gait speed to classify hemiparetic gait dysfunction because it offers clinical predictive capacity. However, gait speed fails to distinguish unique biomechanical characteristics that differentiate aspects of gait dysfunction. RESEARCH QUESTION: Here we describe a novel classification of hemiparetic gait dysfunction based on biomechanical traits of pelvic excursion. We hypothesize that individuals with greater deviation of pelvic excursion, relative to controls, demonstrate greater impairment in key gait characteristics...
March 31, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29627420/exercise-training-causes-a-partial-improvement-through-increasing-testosterone-and-enos-for-erectile-function-in-middle-aged-rats
#15
Dae Yun Seo, Sung Ryul Lee, Hyo Bum Kwak, Hyuntea Park, Kyo Won Seo, Yeon Hee Noh, Kang-Moon Song, Ji-Kan Ryu, Kyung Soo Ko, Byoung Doo Rhee, Jin Han
PURPOSE: Aging changes the balance of sex hormones and causes endothelial dysfunction in the penis, both of which are important determinants of erectile dysfunction (ED). The purpose of this study was to evaluate whether exercise training could protect against erectile dysfunction by increasing serum testosterone and penile eNOS levels in aging rats. METHODS: A total of 14 young (2-month-old) and 14 middle-aged (18-month-old) Sprague Dawley rats were randomly assigned to either untrained control (young control, [YC], middle-aged control, [MC]) or endurance exercise-trained (young exercise, [YE], middle-aged exercise, [ME]) groups with seven rats per group...
April 5, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29627383/lpaat%C3%AE-agpat4-deficiency-impairs-maximal-force-contractility-in-soleus-and-alters-fibre-type-in-extensor-digitorum-longus-muscle
#16
Ryan M Bradley, Darin Bloemberg, Juan J Aristizabal Henao, Ashkan Hashemi, Andrew S Mitchell, Val A Fajardo, Catherine Bellissimo, Emily B Mardian, Eric Bombardier, Marie-France Paré, Katherine A Moes, Ken D Stark, A Russell Tupling, Joe Quadrilatero, Robin E Duncan
Lysophosphatidic acid acyltransferase (LPAAT) δ/acylglycerophosphate acyltransferase 4 is a mitochondrial enzyme and one of five homologues that catalyze the acyl-CoA-dependent synthesis of phosphatidic acid (PA) from lysophosphatidic acid. We studied skeletal muscle LPAATδ and found highest levels in soleus, a red oxidative fibre-type that is rich in mitochondria, and lower levels in extensor digitorum longus (EDL) (white glycolytic) and gastrocnemius (mixed fibre-type). Using Lpaatδ-deficient mice, we found no change in soleus or EDL mass, or in treadmill time-to-exhaustion compared to wildtype littermates...
April 5, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29626840/treadmill-walking-reduces-pre-frontal-activation-in-patients-with-parkinson-s-disease
#17
Pablo Cornejo Thumm, Inbal Maidan, Marina Brozgol, Shiran Shustak, Eran Gazit, Shirley Shema Shiratzki, Hagar Bernad-Elazari, Yoav Beck, Nir Giladi, Jeffrey M Hausdorff, Anat Mirelman
BACKGROUND: Among patients with Parkinson's disease (PD), gait is typically disturbed and less automatic. These gait changes are associated with impaired rhythmicity and increased prefrontal activation, presumably in an attempt to compensate for reduced automaticity. RESEARCH QUESTION: We investigated whether during treadmill walking, when the pace is determined and fixed, prefrontal activation in patients with PD is lower, as compared to over-ground walking. METHODS: Twenty patients with PD (age: 69...
March 28, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29626513/effects-of-exercise-training-on-adipose-tissue-apelin-expression-in-streptozotocin-nicotinamide-induced-diabetic-rats
#18
Fahimeh Kazemi, Saleh Zahediasl
Apelin is an adipocyte-derived peptide that plays an important role in regulation of energy homoeostasis and decrease of insulin resistance. We investigated the effects of exercise training on adipose tissue apelin expression in streptozotocin-nicotinamide induced diabetic rats. In this experimental study, 38 male Wistar rats were assigned to 4 groups: sedentary diabetic, trained diabetic, sedentary non-diabetic and trained non-diabetic. Type 2 diabetes mellitus (T2DM) was induced by intraperitoneal injection of streptozotocin and nicotinamide in adult rats...
April 4, 2018: Gene
https://www.readbyqxmd.com/read/29626373/sex-dimorphism-of-substrate-utilization-differences-in-skeletal-muscle-mitochondrial-volume-density-and-function
#19
David Montero, Klavs Madsen, Anne-Kristine Meinild-Lundby, Fredrik Edin, Carsten Lundby
Fat oxidation during exercise is higher in females than males. We sought to determine whether sex differences in substrate metabolism are paralleled by distinct skeletal muscle mitochondrial volume density and oxidative capacity. Whole-body substrate (fat, carbohydrate (CHO)) utilization during submaximal treadmill running was assessed and skeletal muscle biopsies were taken to determine mitochondrial volume density (MitoVD ) and function in healthy young females (n = 12) and males (n = 12) matched by aerobic exercise capacity (VO2max ) and exercise performance...
April 6, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29625576/skeletal-cardiac-and-respiratory-muscle-function-and-histopathology-in-the-p448lneo-mouse-model-of-fkrp-deficient-muscular-dystrophy
#20
Qing Yu, Melissa Morales, Ning Li, Alexander G Fritz, Ren Ruobing, Anthony Blaeser, Ershia Francois, Qi-Long Lu, Kanneboyina Nagaraju, Christopher F Spurney
BACKGROUND: Fukutin-related protein (FKRP) mutations are the most common cause of dystroglycanopathies known to cause both limb girdle and congenital muscular dystrophy. The P448Lneo- mouse model has a knock-in mutation in the FKRP gene and develops skeletal, respiratory, and cardiac muscle disease. METHODS: We studied the natural history of the P448Lneo- mouse model over 9 months and the effects of twice weekly treadmill running. Forelimb and hindlimb grip strength (Columbus Instruments) and overall activity (Omnitech Electronics) assessed skeletal muscle function...
April 6, 2018: Skeletal Muscle
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