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https://www.readbyqxmd.com/read/29340346/effects-of-local-drug-and-chemical-compound-delivery-on-bone-regeneration-around-dental-implants-in-animal-models-a-systematic-review-and-meta-analysis
#1
Ali Alenezi, Bruno Chrcanovic, Ann Wennerberg
PURPOSE: One of the suggested methods for enhancing osseointegration is the local application of drug agents around implant surfaces. The aim of this review was to evaluate the methods most commonly used for local drug and chemical compound delivery to implant sites and assess their influence on osseointegration. MATERIALS AND METHODS: An electronic search was undertaken in three databases (PubMed, Scopus, Embase). The search was limited to animal experiments using endosseous implants combined with local drug delivery systems...
January 2018: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29259343/simple-3-4-dihydroxy-l-phenylalanine-surface-modification-enhances-titanium-implant-osseointegration-in-ovariectomized-rats
#2
Ting Ma, Xi-Yuan Ge, Ke-Yi Hao, Bi-Ru Zhang, Xi Jiang, Ye Lin, Yu Zhang
Osteoporosis presents a challenge to the long-term success of osseointegration of endosseous implants. The bio-inspired 3,4-dihydroxy-L-phenylalanine (Dopa) coating is widely used as a basic layer to bind osteogenetic molecules that may improve osseointegration. To date, little attention has focused on application of Dopa alone or binding inhibitors of bone resorption in osteoporosis. Local use of a bisphosphonate such as zoledronic acid (ZA), an inhibitor of osteoclast-mediated bone resorption, has been proven to improve implant osseointegration...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29250668/osseointegration-of-chemically-modified-sandblasted-and-acid-etched-titanium-implant-surface-in-diabetic-rats-a-histological-and-scanning-electron-microscopy-study
#3
Alexandru NemŢoi, Violeta Trandafir, Aurelian Sorin Paşca, Eusebiu Viorel Şindilar, Eliza Drăgan, Guillaume Anthony Odri, Ana NemŢoi, Danisia Haba, Elena Şapte
INTRODUCTION: The aim of this study is to assess the osseointegration of different dental implants surfaces in diabetic rats. MATERIALS AND METHODS: In this study, were used 56 male Wistar rats, average weight of 300-350 g. Diabetes was induced by a single intraperitoneal injection of Streptozotocin. The glucose levels and weight of rats were periodically evaluated. After the diabetes mellitus is confirmed, the sandblasted, large-grit, acid-etched (SLA) and SLActive endosseous dental implants (TAG dental implants, TAG Medical, Israel), made of titanium alloy, Ti-6Al-4V, 1 mm diameter and 3 mm in length were inserted in the distal metaphysis of the left femur...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29249886/the-use-of-cone-beam-computed-tomography-and-three-dimensional-printing-technology-in-the-restoration-of-a-maxillectomy-patient-using-a-dental-implant-retained-obturator
#4
George Michelinakis
This case report presents an alternative method for fabricating an obturator for patients that develop xerostomia and mild trismus following radiation to the Head and Neck region. Multiple initial impression stages are avoided leading to less irritation to soft tissues and less discomfort to the patient. A 69-year-old male patient was referred to our dental practice by the Maxillofacial Surgery Department of the local General Hospital. The patient had undergone a right maxillectomy for removal of a Squamous Cell Carcinoma 2 weeks prior...
October 2017: Journal of Indian Prosthodontic Society
https://www.readbyqxmd.com/read/29170171/dental-implants-in-a-patient-with-suspected-leucocyte-adhesion-deficiency
#5
Ashraf Abu Karaky, Faleh Sawair, Zaid Tamimi, Yazan Hassona
Aggressive periodontitis and premature tooth loss in leucocyte adhesion deficiency (LAD) have adverse functional and psychological consequences on affected individuals. Dental implant rehabilitation might become necessary to overcome the functional and psychological adverse effects of LAD periodontitis, especially in patients with milder forms who are expected to have a relatively normal life expectancy. Outcome of dental implants in patients with LAD has not been previously reported; we describe the dental rehabilitation of a 24-year-old man with clinical features of LAD using endosseous dental implants...
November 23, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29149204/evaluation-of-osseous-integration-of-titanium-orthopedic-screws-with-novel-sla-treatment-in-porcine-model
#6
Tzu-Hsiang Lin, Hsin-Tai Hu, Hsueh-Chun Wang, Meng-Chian Wu, Shu-Wei Wu, Ming-Long Yeh
The success of many endosseous implants in orthopaedic and dental applications depends on the surface characteristics, as they affect osseous integration. Previous investigations indicated that a novel large-grit sand-blasted and acid-etched (SLA) titanium (denoted as SLAffinity-Ti) implant had better bone integration than that of a comparably shaped implant with a plasma-sprayed titanium surface. The purpose of the present investigation was to create a SLAffinity surface on pedicle screws and trauma screws and to compare it with the surfaces of a sand-blasted-only implant and commercial implants in terms of bone integration...
2017: PloS One
https://www.readbyqxmd.com/read/29144982/bone-mesenchymal-stem-cell-secretion-of-srankl-opg-m-csf-in-response-to-macrophage-mediated-inflammatory-response-influences-osteogenesis-on-nanostructured-ti-surfaces
#7
Qian-Li Ma, Liang Fang, Nan Jiang, Liang Zhang, Ying Wang, Yu-Mei Zhang, Li-Hua Chen
Although it has been well established that osteogenic differentiation of bone mesenchymal stem cells (bMSCs) as well as osteoclastic differentiation of macrophages can be manipulated by the nanostructure of biomaterial surfaces, the interactions among the effects of the surface on immune cells and bMSCs remained unknown. Therefore, in this study, the osteogenic behaviors and secretion of osteoclastogenesis-related cytokines of human bMSCs on TiO2 nanotubular (NT) surfaces in conditioned medium (CM) generated by macrophages cultured on the respective NT surfaces (NT-CM) were analyzed...
November 4, 2017: Biomaterials
https://www.readbyqxmd.com/read/29140387/full-mouth-rehabilitation-with-calvarium-bone-grafts-and-dental-implants-for-a-papillon-lef%C3%A3-vre-syndrome-patient-case-report
#8
Bassam M Kinaia, Kristyn Hope, Ahmed Zuhaili, Jean Francois Tulasne
Papillon-Lefèvre syndrome (PLS) is a rare autosomal recessive disorder of keratinization associated with palmoplantar keratoderma and severe periodontitis resulting in complete edentulism in late adolescence. The pathognomonic dental features of PLS are pathologic migration, hypermobility, and exfoliation of the teeth without any signs of root resorption. It has been suggested that an effective way to treat PLS patients presenting early in the disease progression is extraction of the erupted primary dentition or hopeless permanent teeth followed by antibiotic coverage with periodontal therapy for the remaining teeth...
November 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29140386/retrospective-study-of-survival-of-extraoral-endosseous-craniofacial-implants-in-head-and-neck-surgery-patients
#9
Brent J Woods, Arun Chandu
PURPOSE: To determine the survival rate of implants placed in different craniofacial locations and factors affecting survival. MATERIALS AND METHODS: This study retrospectively reviewed a consecutive series of patients treated at the Royal Melbourne Hospital who received craniofacial implants for an array of benign and malignant conditions. Implant survival per site and cumulative survival were determined. Surgical and implant variables were assessed using the Kaplan-Meier and Cox Proportional Hazards Models...
November 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29137166/antimicrobial-and-osseointegration-properties-of-nanostructured-titanium-orthopaedic-implants
#10
REVIEW
Marcus Jäger, Herbert P Jennissen, Florian Dittrich, Alfons Fischer, Hedda Luise Köhling
The surface design of titanium implants influences not only the local biological reactions but also affects at least the clinical result in orthopaedic application. During the last decades, strong efforts have been made to improve osteointegration and prevent bacterial adhesion to these surfaces. Following the rule of "smaller, faster, cheaper", nanotechnology has encountered clinical application. It is evident that the hierarchical implant surface micro- and nanotopography orchestrate the biological cascades of early peri-implant endosseous healing or implant loosening...
November 13, 2017: Materials
https://www.readbyqxmd.com/read/29130804/is-metal-particle-release-associated-with-peri-implant-bone-destruction-an-emerging-concept
#11
T Fretwurst, K Nelson, D P Tarnow, H-L Wang, W V Giannobile
Peri-implant diseases affecting the surrounding structures of endosseous dental implants include peri-implant mucositis and peri-implantitis. The prevalence of peri-implantitis ranges between 15% and 20% after 10 y, highlighting the major challenge in clinical practice in the rehabilitation of dental implant patients. The widespread nature of peri-implant bone loss poses difficulties in the management of biological complications affecting the long-term success of osseointegrated implant reconstructions. Metal and titanium particles have been detected in peri-implant supporting tissues...
November 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29029850/surface-characteristics-of-dental-implants-a-review
#12
REVIEW
F Rupp, L Liang, J Geis-Gerstorfer, L Scheideler, F Hüttig
OBJECTIVES: During the last decades, several changes of paradigm have modified our view on how biomaterials' surface characteristics influence the bioresponse. After becoming aware of the role of a certain microroughness for improved cellular contact and osseointegration of dental titanium implants, the likewise important role of surface energy and wettability was increasingly strengthened. Very recently, synergistic effects of nanoscaled topographical features and hydrophilicity at the implant/bone interface have been reported...
January 2018: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28962664/a-new-concept-for-implant-borne-dental-rehabilitation-how-to-overcome-the-biological-weak-spot-of-conventional-dental-implants
#13
Nils-Claudius Gellrich, Björn Rahlf, Rüdiger Zimmerer, Philipp-Cornelius Pott, Majeed Rana
BACKGROUND: Every endosseous dental implant is dependent on an adequate amount and quality of peri-implant hard and soft tissues and their fully functional interaction. The dental implant could fail in cases of insufficient bone and soft tissues or due to a violation of the soft to hard tissues to implant shoulder interface with arising of a secondary bone loss. METHOD: To overcome this biological weak-spot, we designed a new implant that allows for multi vector endosseous anchorage around the individual underlying bone, which has to be scanned by computed tomography (CT) or Cone beam CT (CBCT) technique to allow for planning the implant...
September 29, 2017: Head & Face Medicine
https://www.readbyqxmd.com/read/28952290/study-of-gsk3b-inhibitors-sb415286-and-sb216763-to-improve-osteoblastic-differentiation-on-microstructured-titanium
#14
S Lumetti, E Calciolari, L Parisi, A Toffoli, S Mazzotta, S Ferrillo, G Ierardo, G M Macaluso, C Galli, E Manfredi
Rough titanium surfaces enhance cell response to activation of Wnt canonical signalling, a pathway required for osteoblast differentiation. The present study investigated the effects of GSK3β-inhibitors SB216763 and SB415286 on osteoblastic differentiation on titanium surfaces with different topography and wettability. Osteoblastic MC3T3 cells were plated on smooth (Pickled), sand-blasted/acid-etched (SLA) or hyper hydrophilic SLA (modSLA) titanium discs and transfected with a reporter vector sys-tem for Wnt canonical signalling...
July 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28945670/irregular-implant-design-decreases-periimplant-stress-and-strain-under-oblique-loading
#15
Ling He, Jiwu Zhang, Xiucheng Li, Hongcheng Hu, Songhe Lu, Zhihui Tang
OBJECTIVES: To investigate whether a different implant geometry with the same potential contact surface area (PCSA) affects the principal stress and strains in bone. MATERIAL AND METHODS: Three-dimensional finite-element models were created with a single endosseous implant embedded in bone. The irregular (IR) dental root-analog implant and regular (R) cylindrical implant with the same PCSA 350 mm were modeled, keeping the size of the thinnest implant wall 0.8 mm, and the thinnest bone wall 1 mm...
October 2017: Implant Dentistry
https://www.readbyqxmd.com/read/28944359/crestal-sinus-lift-using-an-implant-with-an-internal-l-shaped-channel-1-year-after-loading-results-from-a-prospective-cohort-study
#16
Marco Tallarico, David L Cochran, Erta Xhanari, Claudia Dellavia, Elena Canciani, Eitan Mijiritsky, Silvio Mario Meloni
PURPOSE: To evaluate the clinical and radiographic outcomes of a one-stage crestal sinus elevation procedure using a self-tapping endosseous implant system (iRaise, Maxillent, Herzliya, Israel) developed for sinus augmentation, 1 year after loading. MATERIALS AND METHODS: Patients needing restoration in the posterior maxilla with a residual alveolar crest of 3 to 8 mm in height and 5 mm in width distal to the canine as measured on CBCT scan were treated using the iRaise sinus lift system...
2017: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/28927926/short-dental-implants-a-scoping-review-of-the-literature-for-patients-with-head-and-neck-cancer
#17
REVIEW
Faraj Edher, Caroline T Nguyen
STATEMENT OF PROBLEM: Dental implants can be essential in the rehabilitation of various cancer defects, but their ideal placement can be complicated by the limited dimensions of the available host bone. Surgical interventions developed to increase the amount of bone are not all predictable or successful and can sometimes be contraindicated. Short dental implants have been suggested as an alternative option in sites where longer implants are not possible. Whether they provide a successful treatment option is unclear...
September 16, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28803739/two-stage-reconstruction-of-the-severely-deficient-alveolar-ridge-bone-graft-followed-by-alveolar-distraction-osteogenesis
#18
A Rachmiel, O Emodi, D Aizenbud, D Rachmiel, D Shilo
Distraction osteogenesis for the augmentation of severe alveolar bone deficiency has gained popularity during the past two decades. In cases where the vertical bone height is not sufficient to create a stable transport segment, performing alveolar distraction osteogenesis (ADO) is not possible. In these severe cases, a two-stage treatment protocol is suggested: onlay bone grafting followed by ADO. An iliac crest onlay bone graft followed by ADO was performed in 13 patients: seven in the mandible and six in the maxilla...
January 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28793839/roughness-and-hydrophilicity-as-osteogenic-biomimetic-surface-properties
#19
Barbara Boyan, Ethan Major Lotz, Zvi Schwartz
Successful dental and orthopaedic implant outcomes are determined by the degree of osseointegration. Over the last 60 years, endosseous implants have evolved to stimulate osteogenesis without the need for exogenous biologics like bone morphogenetic proteins. An understanding of the interaction between cells and how cells interact with the physical features characteristics of their environments have has led to the development ofse bioactive implants. Implant surfaces that mimic the inherent chemistry, topography, and hydrophilicity wettability of native bone have been shown to provide cells in the osteoblast lineage cells with the structural cues to promote tissue regeneration and net new bone formation...
August 10, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28772697/calcium-phosphate-bioceramics-a-review-of-their-history-structure-properties-coating-technologies-and-biomedical-applications
#20
REVIEW
Noam Eliaz, Noah Metoki
Calcium phosphate (CaP) bioceramics are widely used in the field of bone regeneration, both in orthopedics and in dentistry, due to their good biocompatibility, osseointegration and osteoconduction. The aim of this article is to review the history, structure, properties and clinical applications of these materials, whether they are in the form of bone cements, paste, scaffolds, or coatings. Major analytical techniques for characterization of CaPs, in vitro and in vivo tests, and the requirements of the US Food and Drug Administration (FDA) and international standards from CaP coatings on orthopedic and dental endosseous implants, are also summarized, along with the possible effect of sterilization on these materials...
March 24, 2017: Materials
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