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https://www.readbyqxmd.com/read/29663447/evolution-of-hbv-s-gene-in-the-backdrop-of-hdv-co-infection
#1
Samina Baig, Syed H Abidi, Zahid Azam, Shahid Majid, Saeed Khan, Muhammad R Khanani, Syed Ali
BACKGROUND: HBV-HDV co-infected people have a higher chance of developing cirrhosis, fulminant hepatitis, and hepatocellular carcinoma (HCC) compared to those infected only with HBV. OBJECTIVE: The present study was conducted to investigate HBV genotypes and phylogeny among HBV mono-infected and HBV-HDV co-infected patients, as well as analyze mutations in the surface gene of HBV in mono-infected and co-infected patients. METHODS: A total of 100 blood samples (50 co-infected with HBV and HDV, and 50 mono-infected with HBV only) were collected for this study...
April 16, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29662321/serum-hepatitis-b-core-antibody-levels-predict-hbeag-seroconversion-in-chronic-hepatitis-b-patients-with-high-viral-load-treated-with-nucleos-t-ide-analogs
#2
Shaohang Cai, Zhandong Li, Tao Yu, Muye Xia, Jie Peng
Background: Patients with chronic hepatitis B virus (HBV) infection who are hepatitis B virus e antigen (HBeAg) positive are increasingly being treated with nucleos(t)ide analogs (NUCs). However, the predictive value of serum hepatitis B virus core antibody (HBcAb) levels for HBeAg seroconversion among patients with high viral load remains unclear. Methods: This study consisted of 74 patients with high viral load (HBV DNA >1 × 107 copies/mL) enrolled in a multicenter, randomized, controlled trial, treated with lamivudine and adefovir (N = 32) or entecavir (N = 42) for up to 96 weeks...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29660216/the-prognostic-significance-of-serum-hbeag-on-the-recurrence-and-long-term-survival-after-hepatectomy-for-hepatocellular-carcinoma-a-propensity-score-matching-analysis
#3
Junyi Shen, Jiaye Liu, Chuan Li, Tianfu Wen, Lvnan Yan, Jiayin Yang
The effects of serum hepatitis B e antigen (HBeAg) on the prognosis of hepatocellular carcinoma (HCC) patients after hepatectomy remain controversial. Our aim was to explore the prognostic significance of serum HBeAg on the prognosis of HCC patients using a propensity matching model. Between January 2009 and March 2015, 953 patients with HCC who underwent hepatectomy in West China Hospital were analyzed. Propensity matching analysis was applied and survival analysis was performed using the Kaplan-Meier method...
April 16, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29660214/precore-g1896a-mutation-is-associated-with-reduced-rates-of-hbsag-seroclearance-in-treated-hiv-hepatitis-b-virus-co-infected-patients-from-western-africa
#4
Anders Boyd, Raoul Moh, Sarah Maylin, Mariama Abdou Chekaraou, Nadia Mahjoub, Delphine Gabillard, Xavier Anglaret, Serge Paul Eholié, Constance Delaugerre, Christine Danel, Fabien Zoulim, Karine Lacombe
The nucleotide substitution G1896A on the precore (pc) region has been implicated in virological and serological responses during treatment in hepatitis B virus (HBV)-infected patients. Whether this mutation affects the therapeutic course of HIV-HBV co-infected patients, especially from Western Africa, is unknown. In this prospective cohort study, 86 antiretroviral (ARV)-naïve HIV-HBV co-infected patients from Côte d'Ivoire, initiating ARV-treatment containing lamivudine (n=53) or tenofovir (n=33), had available baseline pc sequences...
April 16, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29659382/tenofovir-versus-entecavir-for-the-treatment-of-acute-on-chronic-liver-failure-due-to-reactivation-of-chronic-hepatitis-b-with-genotypes-b-and-c
#5
Yue-Meng Wan, Yu-Hua Li, Zhi-Yuan Xu, Hua-Mei Wu, Ying Xu, Xi-Nan Wu, Jin-Hui Yang
BACKGROUND AND AIMS: Acute-on-chronic liver failure (ACLF) can be triggered by reactivation of chronic hepatitis B (CHB). Tenofovir disoproxil fumarate (TDF) and entecavir (ETV) are now the most potent antiviral agents for CHB. This study aimed to compare the short-term safety and efficacy of TDF with ETV in the treatment of ACLF due to reactivation of CHB [hepatitis B virus (HBV)-ACLF]. PATIENTS AND METHODS: In total, 67 consecutive patients with HBV-ACLF were divided into TDF group (n=32) receiving daily TDF (300 mg/d) and ETV group (n=35) receiving daily ETV (0...
April 13, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29656833/a-highly-sensitive-and-robust-method-for-hepatitis-b-virus-covalently-closed-circular-dna-detection-in-single-cells-and-serum
#6
Jing-Tao Huang, Ying Yang, Yi-Min Hu, Xing-Hui Liu, Mei-Yan Liao, Roy Morgan, Er-Feng Yuan, Xia Li, Song-Mei Liu
Despite implications of persistence of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) in the development of hepatocellular carcinoma (HCC), little is known about serum cccDNA in HBV-infected diseases. We developed a cccDNA-selective droplet digital PCR (ddPCR) to assess cccDNA content and dynamics across different stages of HCC development. One hundred forty-seven serum samples and 35 formalin-fixed, paraffin-embedded tumor tissues were derived from patients with HCC or HBV hepatitis/cirrhosis...
April 10, 2018: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/29651701/the-pres-deletion-of-hepatitis-b-virus-hbv-is-associated-with-liver-fibrosis-progression-in-patients-with-chronic-hbv-infection
#7
Fan Li, Xiaodong Li, Tao Yan, Yan Liu, Yongqian Cheng, Zhihui Xu, Qing Shao, Hao Liao, Pengyu Huang, Jin Li, Guo-Feng Chen, Dongping Xu
BACKGROUND AND AIMS: Limited data are available regarding the association of hepatitis B virus (HBV) mutations with liver fibrosis in HBV infection. The study aimed to clarify whether HBV preS deletion mutation is associated with liver fibrosis progression. METHODS: A total of 469 patients were enrolled, including 324 with chronic hepatitis B (CHB), 28 with HBV-related compensated liver cirrhosis (LC), and 117 with HBV-related decompensated LC. All CHB and compensated LC patients received liver biopsy...
April 12, 2018: Hepatology International
https://www.readbyqxmd.com/read/29649127/gene-therapy-for-chronic-hbv-can-we-eliminate-cccdna
#8
REVIEW
Kristie Bloom, Mohube Betty Maepa, Abdullah Ely, Patrick Arbuthnot
Chronic infection with the hepatitis B virus (HBV) is a global health concern and accounts for approximately 1 million deaths annually. Amongst other limitations of current anti-HBV treatment, failure to eliminate the viral covalently closed circular DNA (cccDNA) and emergence of resistance remain the most worrisome. Viral rebound from latent episomal cccDNA reservoirs occurs following cessation of therapy, patient non-compliance, or the development of escape mutants. Simultaneous viral co-infections, such as by HIV-1, further complicate therapeutic interventions...
April 12, 2018: Genes
https://www.readbyqxmd.com/read/29649073/safety-of-targeted-prophylaxis-strategy-in-patients-with-resolved-hepatitis-b-virus-infection-receiving-rituximab-for-immune-mediated-diseases
#9
Michele Spinicci, Giacomo Emmi, Laura Dies, Alessandro Barilaro, Gianfranco Vitiello, Jessica Mencarini, Annalisa Cavallo, Alessandro Bartoloni, Filippo Bartalesi
OBJECTIVES: Rituximab (RTX) is a monoclonal antibody that is widely used in hematologic malignancies and immune-mediated diseases (IMID) and has been associated with the risk of hepatitis B virus reactivation (HBVr). Thus, antiviral prophylaxis is recommended before RTX treatment in all patients with chronic hepatitis B virus (HBV) infection and those with resolved infection affected by onco-hematological conditions. By contrast, the correct management of HBsAg-negative/HbcAb-positive patients candidates for RTX-containing regimens for IMID is still debated, owing to few data currently available in this setting...
April 11, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29644712/evolution-of-hbv-s-gene-in-the-backdrop-of-hdv-co-infection
#10
Samina Baig, Syed H Abidi, Zahid Azam, Shahid Majid, Saeed Khan, Muhammad R Khanani, Syed Ali
BACKGROUND: HBV-HDV co-infected people have a higher chance of developing cirrhosis, fulminant hepatitis, and hepatocellular carcinoma (HCC) compared to those infected only with HBV. OBJECTIVE: The present study was conducted to investigate HBV genotypes and phylogeny among HBV mono-infected and HBV-HDV co-infected patients, as well as analyze mutations in the surface gene of HBV in mono-infected and co-infected patients. METHODS: A total of 100 blood samples (50 co-infected with HBV and HDV, and 50 mono-infected with HBV only) were collected for this study...
April 12, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29644524/discontinuation-of-antiviral-prophylaxis-increased-the-risk-of-hepatitis-b-virus-reactivation-in-glomerulonephritis-patients-under-immunotherapy-a-real-life-observation
#11
Jing Fang, Wenge Li, Min Tan, Wen Chen, Cong Zhang, Wenbo Wang, Qianqian Xu, Xinzhen Guo
PURPOSE: Antiviral prophylaxis is proved to be effective in reducing the risk of hepatitis B virus (HBV) reactivation in hepatitis B surface antigen (HBsAg)-positive patients under immunotherapy. But outcomes referring to discontinuation of antiviral prophylaxis in these patients are lacking. METHODS: We performed a retrospective study of 105 HBsAg-positive patients under immunotherapy for glomerulonephritis and evaluated the incidence and risk factors for HBV reactivation...
April 11, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29643189/elevated-hepatic-cd1d-levels-coincide-with-invariant-nkt-cell-defects-in-chronic-hepatitis-b-virus-infection
#12
Xiaosheng Tan, Yajie Ding, Peng Zhu, Rui Dou, Zhihui Liang, Daofeng Yang, Zhiyong Huang, Wei Wang, Xiongwen Wu, Xiufang Weng
Activation of invariant NKT (iNKT) cells manifests antiviral immune responses in vivo. However, clinical trials have failed to show consistent hepatitis B virus (HBV) DNA reduction postadministration of iNKT cell-specific agonist α-galactosylceramide (α-GalCer). In this study, we aimed to investigate HBV infection-related iNKT cell defects and explore iNKT cell-based therapeutic potential for chronic hepatitis B (CHB). Liver specimens from 30 HBV-infected hepatocellular carcinoma patients were collected for CD1d/hepatitis B surface Ag (HBsAg) staining and/or intrahepatic iNKT cell assay...
April 11, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29629677/blood-and-virus-detection-on-barber-clippers
#13
Z Spengane, S Korsman, K Mkentane, L M Davids, W Zemanay, M Africa, S Mbhele, M Nicol, F Gumedze, D Ngwanya, N P Khumalo
BACKGROUND: Bleeding from the popular clean-shave 'chiskop' haircut was recently reported as prevalent in South Africa (SA), a country with 6.9 million HIV-infected people. OBJECTIVES: To investigate the prevalence of barber hair clipper contamination with blood and HIV and hepatitis B viruses. METHODS: Fifty barbers from three townships in Cape Town, SA, were invited to participate. One clipper from each barber was collected immediately after it had been used for a clean-shave haircut...
March 28, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29629109/engineered-janus-probes-modulate-nucleic-acid-amplification-to-expand-the-dynamic-range-for-direct-detection-of-viral-genomes-in-one-microliter-crude-serum-samples
#14
Yue Zhao, Feng Chen, Jing Qin, Jing Wei, Wenhua Wu, Yongxi Zhao
The viral genome load in diverse clinical samples varies over several orders of magnitude ( e.g. 1-104 copies per μL), thus a dynamic range-extended and sensitive analysis method is highly desired. However, existing well-developed nucleic acid amplification systems always suffer from either a limited dynamic range or modest sensitivity for analysis of these samples. Herein, we propose a general engineered Janus probe to modulate the thermodynamics and kinetic properties of the amplification reaction. Through rational regulation, the Janus system improves the performance by both reducing the background and enhancing the signal, expanding the operative dynamic range by 2 orders of magnitude...
January 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29628773/the-mutation-of-hepatitis-b-virus-and-the-prognosis-of-hepatocellular-carcinoma-after-surgery-a-pilot-study
#15
Yaojun Zhang, Junting Huang, Jinbin Chen, Keli Yang, Jiancong Chen, Li Xu, Zhongguo Zhou, Minshan Chen
Background: Although hepatitis B virus (HBV) is still one of the most common etiological factors for hepatocellular carcinoma (HCC), the association between the HBV mutations and the clinical characteristics and prognosis of HBV-related HCC patients (HBV-HCC) after surgical resection remains largely unknown. Materials and methods: A cohort of 131 consecutive patients who received hepatectomy for HBV-HCC were retrospectively enrolled. The HBV genotype and 14 genomic mutations, which have been reported to relate to HCC in liver samples, were sequenced...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29627260/design-synthesis-and-biological-evaluation-of-seco-a-pentacyclic-triterpenoids-3-4-lactone-as-potent-non-nucleoside-hbv-inhibitors
#16
Zhijian Li, Qingxi Min, Haoji Huang, Ruixuan Liu, Yongyan Zhu, Quanhong Zhu
A series of seco-A-pentacyclic triterpenoids-3,4-lactone were synthesized and the anti-HBV activities were evaluated in vitro. Several compounds inhibited the secretion of HBV antigen and the replication of HBV DNA in micromolar level. Compounds D7 and D10, seco-A-oleanane-3,4-lactone, suppressed the HBeAg secretion with IC50 values of 0.14 μM and 0.86 μM respectively, and the inhibitory activities were also confirmed by detecting the fluorescence intensity of FITC-labeled monoclonal mouse HBeAg antibody via flow cytometry...
March 29, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29625557/case-report-lactic-acidosis-and-rhabdomyolysis-during-telbivudine-and-tenofovir-treatment-for-chronic-hepatitis-b
#17
Yue Ying, Yue-Kai Hu, Jia-Lin Jin, Ji-Ming Zhang, Wen-Hong Zhang, Yu-Xian Huang
BACKGROUND: Current treatment options for chronic hepatitis B (CHB) are pegylated interferon alpha and nucleoside analogues (NAs). NAs have relatively fewer side effects than interferon alpha, and generally well tolerated. Previously 12.9% of patients on telbivudine treatment were reported to develop severe elevation of serum creatine phosphokinase (CPK) levels, but related clinical disease, like lactic acidosis (LA) and rhabdomyolysis (RM) were rare. The pathophysiology may be mitochondrial toxicity, for the NAs inhibit not only hepatitis B virus (HBV) polymerase, but also the host mitochondrial DNA polymerase γ...
April 6, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29624818/incidence-of-hbv-infection-in-young-chinese-blood-donors-born-after-mandatory-implementation-of-neonatal-hepatitis-b-vaccination-nationwide
#18
Xi Tang, Jean-Pierre Allain, Hao Wang, Xia Rong, Jinyan Chen, Ke Huang, Ru Xu, Min Wang, Jieting Huang, Qiao Liao, Zhengang Shan, Shengxue Luo, Tingting Li, Chengyao Li, Yongshui Fu
This study was carried out to determine the incidence of HBV infection in the young generation born after mandatory implementation of hepatitis B vaccination since 1992. Repeat blood donors born between 1992 and 1997 were enrolled, who gave blood at least twice during the past three years. Donors were tested for HBV infection markers of HBsAg, anti-HBc, anti-HBs and viral DNA by immunoassays (EIAs) and nucleic acid tests (NAT). A total of 14937 pre-donation screening qualified young repeat donors aged 18-23 were tested with 9 (0...
April 6, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29624802/serum-hepatitis-b-surface-antigen-correlates-with-fibrosis-and-necroinflammation-a-multicentre-perspective-in-china
#19
Zhang Peng, Du Hong-Bo, Tong Guang-Dong, Li Xiao-Ke, Sun Xue-Hua, Chi Xiao-Ling, Xing Yu-Feng, Zhou Zhen-Hua, Li Qin, Chen Bin, Wang Hui, Wang Li, Jin Hua, Mao De-Wen, Wang Xian-Bo, Wu Qi-Kai, Li Fen-Ping, Hu Xiao-Yu, Lu Bing-Jiu, Yang Zhi-Yun, Zhang Ming-Xiang, Shi Wei-Bing, He Qing, Li Yong, Jiang Kai-Ping, Xue Jing-Dong, Li Xiao-Dong, Jiang Jun-Min, Lu Wei, Tian Guang-Jun, Hu Zhen-Bin, Guo Jian-Chun, Li Cheng-Zhong, Deng Xin, Luo Xin-la, Li Feng-Yi, Zhang Xin-Wei, Zheng Ying-Jun, Zhao Gang, Wang Li-Chun, Wu Jian-Hua, Guo Hui, Mi Yu-Qiang, Gong Zuo-Jiong, Wang Cheng-Bao, Jiang Feng, Guo Peng, Yang Xian-Zhao, Shi Wei-Qun, Yang Hong-Zhi, Zhou Yong, Sun Ning-Ning, Jiao Yun-Tao, Gao Yue-Qiu, Zhou Da-Qiao, Ye Yong-An
The kinetics of serum hepatitis B surface antigen (HBsAg) during the natural history of hepatitis B virus (HBV) infection has been studied, but the factors affecting them remain unclear. AIMS: We aimed to investigate the factors affecting HBsAg titers, using data from multi-center, large-sized clinical trials in China. The baseline data of 1,795 patients in three multi-center trials were studied, and the patients were classified into three groups: hepatitis B early antigen (HBeAg)-positive chronic HBV infection (n=588), HBeAg-positive chronic hepatitis B (n=596), and HBeAg-negative chronic hepatitis B (n=611)...
April 6, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29624717/sirt3-restricts-hbv-transcription-and-replication-via-epigenetic-regulation-of-cccdna-involving-suv39h1-and-setd1a-histone-methyltransferases
#20
Ji-Hua Ren, Jie-Li Hu, Sheng-Tao Cheng, Hai-Bo Yu, Vincent Kam Wai Wong, Betty Yuen Kwan Law, Yong-Feng Yang, Ying Huang, Yi Liu, Wei-Xian Chen, Xue-Fei Cai, Hua Tang, Yuan Hu, Wen-Lu Zhang, Xiang Liu, Quan-Xin Long, Li Zhou, Na-Na Tao, Hong-Zhong Zhou, Qiu-Xia Yang, Fang Ren, Lin He, Rui Gong, Ai-Long Huang, Juan Chen
Hepatitis B virus (HBV) infection remains a major health problem worldwide. Maintenance of the covalently closed circular DNA (cccDNA) which serves as a template for HBV RNA transcription is responsible for the failure of eradicating chronic HBV during current antiviral therapy. cccDNA is assembled with cellular histone proteins into chromatin, but little is known about the regulation of HBV chromatin by histone posttranslational modifications. In this study, we identified SIRT3 as a host factor restricting HBV transcription and replication by screening seven members of Sirtuin family which is the class III histone deacetylase...
April 6, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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