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ovarian carcinosarcoma

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https://www.readbyqxmd.com/read/28791266/prognostic-assessment-of-sarcomatous-histologic-subtypes-of-ovarian-carcinosarcoma
#1
Hyun Jin Kim, Hyun-Mi Lee, Mi Kyung Kim, Yoo-Kyung Lee, In-Ho Lee, Ki-Heon Lee, Hyesun Kim
OBJECTIVE: Ovarian carcinosarcoma is a rare subtype of this disease that has not been thoroughly investigated. The aim of this study was to evaluate the prognostic factors and out comes in patients with ovarian carcinosarcoma. METHODS: All patients with histologically confirmed ovarian carcinosarcoma who were treated at Cheil General Hospital and Women's Healthcare Center between January 2000 and December 2015 were identified and analyzed. Data were extracted from medical records, and statistical analyses were performed to determine correlations between clinicopathological parameters and survival outcomes...
July 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28790096/paraneoplastic-cerebellar-degeneration-secondary-to-ovarian-carcinosarcoma-a-cerebellar-conundrum
#2
Julian David Birch, Arup Sen, Katherine Rowland, Tatyana Viner
We present a case of an elderly female patient who presented with a 6-month history of progressive slurred speech, vertigo, unsteadiness and falls. She underwent an extensive battery of neurological and cardiovascular investigations, none of which demonstrated a diagnostic cause for her symptoms. She was referred to the stroke and neurology teams and was started on treatment for presumed anxiety. As her symptoms continued to progress, she was referred to the falls service. Following a multidisciplinary team discussion, she was reviewed by the consultant geriatrician who felt this may be due to a malignancy so the consultant geriatrician arranged blood testsand CT scan of her chest, abdomen and pelvis...
August 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28679774/syd985-a-novel-duocarmycin-based-her2-targeting-antibody-drug-conjugate-shows-antitumor-activity-in-uterine-and-ovarian-carcinosarcoma-with-her2-neu-expression
#3
Gulden Menderes, Elena Bonazzoli, Stefania Bellone, Jonathan D Black, Federica Predolini, Francesca Pettinella, Alice Masserdotti, Luca Zammataro, Gary Altwerger, Natalia Buza, Pei Hui, Serena Wong, Babak Litkouhi, Elena Ratner, Dan-Arin Silasi, Masoud Azodi, Peter E Schwartz, Alessandro D Santin
Purpose: Carcinosarcomas (CS) are highly aggressive gynecologic malignancies containing both carcinomatous and sarcomatous elements with heterogeneous HER2/neu expression. We compared the efficacy of SYD985, (Synthon Biopharmaceuticals BV), a novel HER2-targeting antibody-drug conjugate (ADC), to Trastuzumab emtansine (T-DM1, Genentech-Roche) against primary uterine and ovarian CS. <p>Experimental Design: Eight primary CS cell lines were evaluated for HER2/neu surface expression by IHC and gene amplification by FISH assays...
July 5, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28625283/uterine-and-ovarian-carcinosarcomas-do-they-behave-similarly
#4
Isin Ureyen, Alper Karalok, Derya Akdag Cirik, Tolga Tasci, Zeynep Kestel Gokce, Ipeknur Balin Duzguner, Gokhan Tulunay, Taner Turan
OBJECTIVE: We aimed to compare the clinicopathologic characteristics, recurrence patterns, and survival of patients with ovarian carcinosarcomas (OCs) and uterine carcinosarcomas (UCs). METHODS: Patients who were diagnosed with UCs or OCs on the basis of final pathology reports and who underwent surgery between January 1993 and January 2015 were included in the study. Data of patients were obtained from Gynecological Oncology Clinic electronic database and patient files...
July 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28608929/high-grade-serous-carcinomas-arise-in-the-mouse-oviduct-via-defects-linked-to-the-human-disease
#5
Yali Zhai, Rong Wu, Rork Kuick, Michael S Sessine, Stephanie Schulman, Megan Green, Eric R Fearon, Kathleen R Cho
Recent studies suggest that the most common and lethal type of "ovarian" cancer, high-grade serous carcinoma (HGSC), usually arises from epithelium on the fallopian tube fimbriae, and not from the ovarian surface epithelium (OSE). We have developed Ovgp1-iCreER(T2) mice in which the Ovgp1 promoter controls expression of tamoxifen (TAM)-regulated Cre recombinase in oviductal epithelium - the murine equivalent of human fallopian tube epithelium (FTE). We employed Ovgp1-iCreER(T2) mice to show that FTE-specific inactivation of several different combinations of tumour suppressor genes recurrently mutated in human HGSCs - namely Brca1, Trp53, Rb1, and Nf1 - results in serous tubal intraepithelial carcinomas (STICs) that progress to HGSC or carcinosarcoma, and to widely metastatic disease in a subset of mice...
June 13, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28593890/extremely-locally-advanced-ovarian-malignant-mixed-mullerian-tumor-in-37-years-old-female
#6
Gjorgji Jota, Radomir Gelevski, Zoran Karadzov, Redzep Selmani, Magdalena Genadieva-Dimitrova, Margarita Peneva, Vesna Jovanovska-Manevska
Ovarian carcinosarcomas, rare variant of ovarian carcinoma, composed of both carcinomatous and mesenchymal components, solid and/or cystic, fleshy and hemorrhagic, frequently spreading beyond the ovary, are treated with surgery and adjuvant chemotherapy according to the treatment principles of ovarian carcinomas due to the small number of reported cases and lack of randomized studies. We report a case of a 37-year-old woman with clinical signs of extremely locally advanced tumor of ovarian origin, infiltrating the lower left quadrant of the abdominal wall with necrosis of the covering skin...
March 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/28593778/-current-figo-staging-classification-for-cancer-of-ovary-fallopian-tube-and-peritoneum
#7
I Šišovská, L Minář, M Felsinger, M Anton, M Bednaříková, J Hausnerová, E Jandáková, V Weinberger
INTRODUCTION: Pelvic high-grade serous carcinomas (HGSCs) include carcinoma of ovary, fallopian tube, and peritoneum. Five-year survival, irrespective of the stage, is between 35-40%. Most patients are diagnosed in advanced stages of the disease. The new revised and expanded dualistic model of ovarian carcinogenesis shows that type II tumors are composed for the most part of high-grade serous ovarian carcinoma, carcinosarcoma, undifferentiated carcinoma and can be further subdivided into morphologic and molecular subtypes...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/28546804/synchronous-uterine-adenocarcinoma-and-leiomyosarcoma-a-case-study
#8
Kamila Dudzik, Agnieszka Krzysteczko, Leon Kolny, Agnieszka Bąk, Ewelina Stawicka-Ociepka, Krzysztof Nowosielski
Synchronous gynecological cancers are rarely described. Those cases account for approximately up to 6% of female genital tract malignancies. The presence of synchronous endometrial adenocarcinoma and gynecological tract neoplasia is rare - the most commonly described is synchronous adenocarcinoma and endometrial ovarian cancer (accounting for 15-20% of ovarian neoplasia and 5% of endometrial cancers). Concomitant uterine carcinosarcoma and ovarian cancer, or endometrial adenocarcinoma are extremely rare. Up till now, only 3 cases of synchronous adenocarcinoma and leiomyosarcoma were described...
March 2017: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/28498249/clinicopathological-characteristics-and-prognostic-factors-of-synchronous-endometrial-and-ovarian-cancers-a-single-institute-review-of-43-cases
#9
Vandana Jain, Rupinder Sekhon, Sunil Pasricha, Shveta Giri, Kanika Batra Modi, Eliza Shrestha, Dharma Ram, Sudhir Rawal
OBJECTIVES: The objectives of our study were to demonstrate the clinicopathological characteristics and determine the prognostic factors for women with synchronous primary cancers of the endometrium and ovary. METHODS: A retrospective analysis of 43 pathologically proven cases of synchronous primary endometrial and ovarian cancers diagnosed between January 2005 and December 2015 was carried out. Patients with uterine sarcomas, carcinosarcomas, borderline tumors, and nonepithelial tumors of the ovary and patients who received neoadjuvant chemotherapy were excluded from the study...
June 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28469317/impact-of-surepath-%C3%A2-liquid-based-preparation-in-cytological-analysis-of-peritoneal-washing-in-practice-of-gynecologic-oncology
#10
Ruchita Tyagi, Nalini Gupta, Priyanka Bhagat, Shalini Gainder, Bhavna Rai, L K Dhaliwal, Arvind Rajwanshi
CONTEXT: Peritoneal washing is performed for staging of gynecologic tumors to detect subclinical intraperitoneal metastases. AIM: The aim of the present study was to assess the impact of SurePath™ liquid-based cytology (LBC) in peritoneal washing in various gynecological malignancies. SETTINGS AND DESIGN: An audit of peritoneal-fluid/washing (January 2012 to July 2013) was performed with corresponding gynecologic specimens. All peritoneal washings were processed using both conventional and LBC technique...
April 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28296680/primitive-neuroectodermal-tumors-of-the-female-genital-tract-a-morphologic-immunohistochemical-and-molecular-study-of-19-cases
#11
Sarah Chiang, Matija Snuderl, Sakiko Kojiro-Sanada, Ariadna Quer Pi-Sunyer, Dean Daya, Tohru Hayashi, Luisanna Bosincu, Fumihiro Ogawa, Andrew E Rosenberg, Lars-Christian Horn, Lu Wang, A John Iafrate, Esther Oliva
Primary primitive neuroectodermal tumor (PNET) of the female genital tract is rare, and its proper classification remains unclear. The clinical, histologic, and immunophenotypic features as well as EWSR1 rearrangement status of 19 gynecologic PNETs, including 10 ovarian, 8 uterine, and 1 vulvar tumors, are herein reported. Patient age ranged from 12 to 68 years, with a median age of 20 and 51 years among those with ovarian and uterine PNETs, respectively. Morphologic features of central nervous system (CNS) tumors were seen in 15 PNETs, including 9 medulloblastomas, 3 ependymomas, 2 medulloepitheliomas, and 1 glioblastoma, consistent with central PNET...
June 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28125702/clinical-significance-of-programmed-death-ligand%C3%A2-1-and-intra-tumoral-cd8-t-lymphocytes-in-ovarian-carcinosarcoma
#12
Jun Zhu, Hao Wen, Xingzhu Ju, Rui Bi, Wenjia Zuo, Xiaohua Wu
Ovarian carcinosarcoma (OCS) accounts for high mortality and lacks effective therapeutic methods. So far, we lack reliable biomarkers capable of predicting the risk of aggressive course of the disease. Programmed death ligand-1 (PD-L1) is expressed in various tumors, and antibodies targeting its receptor programmed cell death 1 (PD-1) are emerging cancer therapeutics. This study was designed to evaluate the expression of PD-L1 and intratumoral CD8+ T lymphocytes by immunohistochemistry from 19 OCS patients who underwent primary surgery at Fudan University Shanghai Cancer Center...
2017: PloS One
https://www.readbyqxmd.com/read/28032649/kras-mutation-coupled-with-p53-loss-is-sufficient-to-induce-ovarian-carcinosarcomas-in-mice
#13
Feng-Hsiang Tang, Tsung-Hua Hsieh, Chia-Yi Hsu, Hsiao-Yun Lin, Cheng-Yu Long, Kuang-Hung Cheng, Eing-Mei Tsai
Ovarian carcinosarcoma cancer is the most lethal form of gynecological malignancy, but the pathogenesis and biological function for this ovarian cancer remain unknown. We establishment the transgenic mouse model of K-ras(G12D) p53(loxP/loxP) and found that K-ras mutation and p53 deletion within the ovarian surface epithelium gave rise to ovarian lesions with a hyperproliferation and endometrioid glandular morphology. Furthermore, double mutant ovaries formed ovarian carcinosarcomas that were high grade and poorly differentiated...
April 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27958685/pazopanib-as-a-second-line-treatment-for-uterine-and-ovarian-carcinosarcoma-a-single-institutional-study
#14
Tadaaki Nishikawa, Kosei Hasegawa, Akira Yabuno, Hiroyuki Yoshida, Masanori Yasuda, Eito Kozawa, Keiichi Fujiwara
No abstract text is available yet for this article.
January 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27921006/survival-and-control-prognosticators-of-recurrent-gynecological-malignancies-of-the-pelvis-and-para-aortic-region-treated-with-stereotactic-body-radiation-therapy
#15
Shaakir Hasan, Anthony Ricco, Kaylette Jenkins, Rachelle Lanciano, Alexandra Hanlon, John Lamond, Jun Yang, Jing Feng, Michael Good, Joel Noumoff, Luther Brady
PURPOSE: To define prognostic factors associated with improved survival and local control (LC) for gynecologic cancer recurrences limited to the pelvis and para-aortic (PA) region using stereotactic body radiation therapy (SBRT). METHODS: Between 2/2008 and 7/2014, 30 women (35 targets) with pelvic or PA recurrence of endometrioid (n = 12), cervical (n = 11), ovarian (n = 3), uterine-serous (n = 2), or carcinosarcoma (n = 2) cancer were treated with SBRT...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27870704/clinical-outcomes-for-stereotactic-ablative-radiotherapy-in-oligometastatic-and-oligoprogressive-gynecological-malignancies
#16
Shane Mesko, Kiri Sandler, Joshua Cohen, Gottfried Konecny, Michael Steinberg, Mitchell Kamrava
OBJECTIVES: We report single-institution clinical outcomes of women treated with stereotactic ablative radiotherapy (SABR) for oligometastatic or progressive gynecological malignancies. MATERIALS AND METHODS: From 2009 to 2015, 47 lesions from 28 patients were treated with SABR and retrospectively analyzed. All patients had oligometastatic (93%) or oligoprogressive (7%) disease. Primary cancer diagnoses were 15 ovarian, 8 endometrial, 2 cervical, 2 vaginal, and 1 uterine carcinosarcoma...
February 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27833321/rare-case-of-an-ovarian-vein-tumor-thrombosis-identified-on-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#17
Piyush Chandra, Archi Agrawal, Nilendu Purandare, Sneha Shah, Venkatesh Rangarajan
Fludeoxyglucose positron emission tomography/computed tomography is valuable in the identification of tumor thrombus and differentiating it from bland thrombus which has implications in initiating anticoagulation. We present a rare case of tumor thrombosis in ovarian vein, in a recurrent case of uterine carcinosarcoma.
October 2016: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/27819640/mature-teratoma-associated-with-bilateral-ovarian-carcinosarcoma-accidental-association-or-etiopathogenetic-determinism-case-report
#18
Rodica Birla, Elena-Roxana Catanescu, Andrei Caragui, Silviu Constantinoiu
Carcinosarcoma is a rare form of ovarian cancer with mixed origin, and its association with mature teratoma is extremely rare. We present the case of patient T. M. aged 67, admitted into our clinic on the 15/05/2016, F.O. 4877 for the increase of the abdominal volume. On admission, the patient was afebrile, conscious, cooperative, cardio-respiratory balanced, having the abdomen distended in volume, sharp dullness in the flanks, positive wave sign bioumoral within normal limits except: uric acid = 6.64 mg / dL, serum glucose = 113...
2016: Chirurgia
https://www.readbyqxmd.com/read/27807494/ovarian-carcinosarcoma-and-its-association-with-mature-cystic-teratoma-and-primary-tubal-carcinoma
#19
Sunida Rewsuwan, Nopporn Satabongkoch, Prapaporn Suprasert, Surapan Khunamornpong
Introduction. Carcinosarcoma is an uncommon form of ovarian cancers, classified as being part of the group of mixed epithelial and mesenchymal tumors. The occurrence of carcinosarcoma in association with a mature cystic teratoma and synchronous tubal carcinoma is very rare. Case Report. A 69-year-old woman presented with a pelvic mass. An abdominal computerized tomographic scan detected a 15 cm right pelvic mass which was suggestive of malignant transformation of a dermoid cyst. Intraoperative, bilateral ovarian masses (left 10 cm and right 12 cm) with diffuse peritoneal metastatic nodules were identified...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27791010/mutational-landscape-of-uterine-and-ovarian-carcinosarcomas-implicates-histone-genes-in-epithelial-mesenchymal-transition
#20
Siming Zhao, Stefania Bellone, Salvatore Lopez, Durga Thakral, Carlton Schwab, Diana P English, Jonathan Black, Emiliano Cocco, Jungmin Choi, Luca Zammataro, Federica Predolini, Elena Bonazzoli, Mark Bi, Natalia Buza, Pei Hui, Serena Wong, Maysa Abu-Khalaf, Antonella Ravaggi, Eliana Bignotti, Elisabetta Bandiera, Chiara Romani, Paola Todeschini, Renata Tassi, Laura Zanotti, Franco Odicino, Sergio Pecorelli, Carla Donzelli, Laura Ardighieri, Fabio Facchetti, Marcella Falchetti, Dan-Arin Silasi, Elena Ratner, Masoud Azodi, Peter E Schwartz, Shrikant Mane, Roberto Angioli, Corrado Terranova, Charles Matthew Quick, Babak Edraki, Kaya Bilgüvar, Moses Lee, Murim Choi, Amy L Stiegler, Titus J Boggon, Joseph Schlessinger, Richard P Lifton, Alessandro D Santin
Carcinosarcomas (CSs) of the uterus and ovary are highly aggressive neoplasms containing both carcinomatous and sarcomatous elements. We analyzed the mutational landscape of 68 uterine and ovarian CSs by whole-exome sequencing. We also performed multiregion whole-exome sequencing comprising two carcinoma and sarcoma samples from six tumors to resolve their evolutionary histories. The results demonstrated that carcinomatous and sarcomatous elements derive from a common precursor having mutations typical of carcinomas...
October 25, 2016: Proceedings of the National Academy of Sciences of the United States of America
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