keyword
MENU ▼
Read by QxMD icon Read
search

uterine carcinoma

keyword
https://www.readbyqxmd.com/read/29332133/fumarate-hydratase-fh-deficiency-in-uterine-leiomyomas-recognition-by-histological-features-versus-blind-immunoscreening
#1
Lisa Siegler, Ramona Erber, Stefanie Burghaus, Tobias Brodkorb, David Wachter, Nafisa Wilkinson, James Bolton, Helen Stringfellow, Florian Haller, Matthias W Beckmann, Arndt Hartmann, Abbas Agaimy
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome is a rare autosomal dominant disease caused by germline mutations in the fumarate hydratase (FH) gene. Affected individuals develop cutaneous and uterine leiomyomas and aggressive RCC. To date, only few publications described the frequency and morphology of FH-deficient uterine leiomyomas. We reviewed 22 cases collected over 8 years from routine and consultation files based on distinctive histological features. In addition, we screened 580 consecutive uterine leiomyomas from 484 patients, 23 extra-uterine and 8 uterine leiomyosarcomas, and 6 leiomyomas with bizarre nuclei for FH loss using immunohistochemistry (IHC) on tissue microarrays (TMAs)...
January 13, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29331043/role-of-mir-203-in-estrogen-receptor-mediated-signaling-in-the-rat-uterus-and-endometrial-carcinoma
#2
Oliver Zierau, Janina Helle, Sabina Schadyew, Yanni Morgenroth, Martin Bentler, Alexander Hennig, Sridar Chittur, Martin Tenniswood, Georg Kretzschmar
The role of microRNAs (miRNA) in estrogen receptor (ER) signaling in the uterus and in endometrial cancer is not well understood. We therefore analyzed miRNA expression in uterine samples from a standard three-day uterotrophic assay using young female adult rats to identify E2-regulated miRNAs. Microarray analysis identified 47 E2 down-regulated miRNAs including miR-30a, and 25 E2up-regulated miRNAs including miR-672, miR-203 and miR-146b. The strongly E2-upregulated miR-203 was selected for further analysis...
January 13, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29317075/the-origin-of-endometriosis-associated-ovarian-cancer-from-uterine-neoplastic-lesions
#3
Elisabetta Garavaglia, Cristina Sigismondi, Stefano Ferrari, Massimo Candiani
Endometriosis is a risk factor for type I epithelial ovarian cancer but an issue to be clarified is the site of origin of endometriosis associated ovarian cancer. Here we proposed that the uterus may be the organ of origin of ovarian endometrioid cancer associated with endometriosis. Thus, the first neoplastic transformation would characterize the uterine cells migrating in the pelvis via retrograde menstruation and they would implant secondarily on the ovary. Supporting this hypothesis, an higher incidence of synchronous precancerous and cancerous endometrial pathology in patients affected by ovarian endometrioid cancer associated with endometriosis was showed...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29313317/laparoscopic-excision-of-an-unusual-presentation-of-a-nabothian-cyst-case-report-and-review-of-the-literature
#4
Joseph Nassif, Hasan Nahoul, Ali Mourad, Ryan Yammine, Sally Khoury, Ali Khalil
Nabothian cysts are mucinous retention cysts formed through the accumulation of cervical mucus inside blocked cervical crypts leading to non-neoplastic mucinous cystic lesion in relation to the uterine cervix. The formation of Nabothian cysts is a common gynecological benign condition in women of reproductive age. While the presence of small-sized Nabothian cysts is usually clinically asymptomatic and requires no treatment or intervention, the diagnosis of larger Nabothian cysts can be mistaken with malignant tumors, including mucin producing carcinomas such as Adenoma malignum...
December 22, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29303407/vaginoplasty-with-acellular-dermal-matrix-after-radical-resection-for-carcinoma-of-the-uterine-cervix
#5
Zhi Wang, Jiuzuo Huang, Ang Zeng, Ming Wu, Xiaojun Wang
Various methods are available for vaginoplasty, but many of them have the drawbacks including surgical complexity and postoperative pain at the donor site. We herein evaluated the outcomes of vaginoplasty using tissue-engineered biomaterial graft. This study included 16 early stage cervical cancer patients who received curative surgery in combination with radiotherapy. They underwent vaginoplasty with tissue-engineered biological material, acellular dermal matrix (ADM). After treatment, a vaginal dilator was advised to be used for 6 months to prevent contraction of vagina...
January 5, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29302811/gene-expression-analysis-in-peripheral-blood-cells-of-patients-with-hereditary-leiomyomatosis-and-renal-cell-cancer-syndrome-hlrcc-identification-of-nrf2-pathway-activation
#6
Carolina Arenas Valencia, Liliana Lopez Kleine, Andres M Pinzon Velasco, Andrea Y Cardona Barreto, Clara E Arteaga Diaz
Hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC) is a very rare disease that is inherited in an autosomal dominant manner. Affected patients may develop from cutaneous and uterine leiomyomas to type 2 papillary renal cell carcinoma (Schmidt and Linehan, Int J Nephrol Renovasc Dis 7:253-260, 2014). HLRCC is caused by germline mutations in the FH gene, which produces the fumarate hydratase protein that participates in the tricarboxylic acid cycle during the conversion of fumarate to malate. In FH-deficient cells, high concentrations of fumarate lead to a series of intricate events, which seem to be responsible for the malignant transformation (Yang et al...
January 4, 2018: Familial Cancer
https://www.readbyqxmd.com/read/29290193/spectrum-of-gynecological-malignancies-at-jamshoro
#7
Naheed Parveen, Raheel Sikander, Majida, Shaheen
OBJECTIVE: To describe the frequency and spectrum of different types of gynecological malignancies. STUDY DESIGN: An observational study. PLACE AND DURATION OF STUDY: Department of Obstetrics and Gynaecology, Liaquat University of Medical and Health Sciences, Jamshoro, from January 2014 to December 2015. METHODOLOGY: All patients with gynecological malignancies, admitted at the study place, whether previously diagnosed or need to establish the diagnosis on the basis of EUA, biopsy, staging and for surgery during the study period were included...
January 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29285283/diffusion-weighted-mri-derived-adc-values-reflect-collagen-i-content-in-pdx-models-of-uterine-cervical-cancer
#8
Anette Hauge, Catherine S Wegner, Jon-Vidar Gaustad, Trude G Simonsen, Lise Mari K Andersen, Einar K Rofstad
Apparent diffusion coefficient (ADC) values derived from diffusion-weighted magnetic resonance imaging (DW-MRI) are known to reflect the cellular environment of biological tissues. However, emerging evidence accentuates the influence of stromal elements on ADC values. The current study sought to elucidate whether a correlation exists between ADC and the fraction of collagen I-positive tissue across different tumor models of uterine cervical cancer. Early and late generation tumors of four patient-derived xenograft (PDX) models of squamous cell carcinoma (BK-12, ED-15, HL-16, and LA-19) were included...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29283433/congems-condensed-gene-co-expression-module-discovery-through-rule-based-clustering-and-its-application-to-carcinogenesis
#9
Saurav Mallik, Zhongming Zhao
For transcriptomic analysis, there are numerous microarray-based genomic data, especially those generated for cancer research. The typical analysis measures the difference between a cancer sample-group and a matched control group for each transcript or gene. Association rule mining is used to discover interesting item sets through rule-based methodology. Thus, it has advantages to find causal effect relationships between the transcripts. In this work, we introduce two new rule-based similarity measures-weighted rank-based Jaccard and Cosine measures-and then propose a novel computational framework to detect condensed gene co-expression modules ( C o n G E M s) through the association rule-based learning system and the weighted similarity scores...
December 28, 2017: Genes
https://www.readbyqxmd.com/read/29279587/cyclooxygenase-2-cox2-expression-in-adenocarcinoma-surpasses-that-of-squamous-cell-carcinoma-in-the-uterine-cervix
#10
A K Marutha Muthu, P L Cheah, C C Koh, M F Chew, Y F Toh, L M Looi
Over the years, adenocarcinoma (ADC), which has a worse prognosis than squamous cell carcinoma (SCC) of the cervix, has shown an increasing trend. Cyclooxygenase-2 (COX2) expression which has been associated with worse prognosis in several solid cancers was studied for its association with SCC and ADC of the cervix. 35 histologically re-confirmed SCC and 35 ADC were immunohistochemically stained for COX2 using a mouse monoclonal antibody to COX2 (1:100; Dako: Clone CX-294) on a Ventana Benchmark XT. The histoscore was computed as intensity of staining, semi-quantitated on a scale of 0-3 with 0 = negative, 1 = weak, 2 = moderate and 3 = strong staining intensity; multiplied by percentage of immunopositivity on a scale of 0-4 with 0 = <1%, 1 = 1-25%, 2 = 26-50%, 3 = 51-75% and 4 = ≥75% of immunopositive tumour cells...
December 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29277809/long-term-outcomes-of-carbon-ion-radiotherapy-for-locally-advanced-squamous-cell-carcinoma-of-the-uterine-cervix
#11
Noriyuki Okonogi, Masaru Wakatsuki, Shingo Kato, Shintaro Shiba, Daijiro Kobayashi, Hiroki Kiyohara, Kumiko Karasawa, Tatsuya Ohno, Takashi Nakano, Tadashi Kamada, Makio Shozu
BACKGROUND/AIM: To evaluate the long-term outcomes of carbon-ion radiotherapy (C-ion RT) for locally advanced cervical squamous cell carcinoma (LAC-SqCC) in 2 prospective phase I/II studies. PATIENTS AND METHODS: In the first study, 14 patients were treated with 68.8-72.8 Gy (RBE)/24 fractions. In a subsequent study, 22 patients were treated with 64.0-72.0 Gy (RBE)/20 fractions while limiting the dose to the gastro-intestinal (GI) <60 Gy (RBE). RESULTS: The 10-year local control rates were 92% and 61% for the patients administered a total dose of 72...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29259654/a-case-of-large-cell-neuroendocrine-carcinoma-of-the-uterine-cervix-misdiagnosed-as-adenocarcinoma-in-thinprep-cytology-test
#12
Jong-Hee Nam, Jongin Na, Nah-Ihm Kim, Ga-Eon Kim, Chang-Soo Park, Yoo-Duk Choi
Large cell neuroendocrine carcinoma (LCNEC) of uterine cervix is a rare malignancy with aggressive behavior and poor clinical outcome even in its early stage. Few cytopathologic features of cervical LCNEC have been reported previously. A 57-year-old postmenopausal African American female, presented to the local health department with a chief complaint of heavy vaginal bleeding. A 45-year-old female presented with 20 months of vaginal pruritus and foul odor. Cervical malignancy was suspected by pelvis magnetic resonance imaging...
2017: CytoJournal
https://www.readbyqxmd.com/read/29251612/-interstitial-collagenase-and-their-endogenous-regulators-in-squamous-cell-cervical-carcinoma
#13
O S Timoshenko, T A Gureeva, E V Kugaevskaya, L E Zavalishina, N I Solovyeva
Interstitial collagenase (MMP-1) belongs to the family of matrix metalloproteinases (MMP), which play a key role in generalization processes of invasion and metastasis, which determine the degree of tumor malignancy. MMP-1 refers to secreted, inducible MMP, the expression of which in normal tissues is not defined. Induction of expression of MMP in CSS in the tumor occurs under the action of oncogenes of HPV, and in areas adjacent to the tumor normal tissue under the action of the inductor expression of MMP - EMMPRIN (CD147), which expressively on the surface of tumor cells...
November 2017: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/29248197/significance-of-venous-thromboembolism-in-women-with-uterine-carcinosarcoma
#14
Koji Matsuo, Malcolm S Ross, Dwight D Im, Merieme M Klobocista, Stephen H Bush, Marian S Johnson, Tadao Takano, Erin A Blake, Yuji Ikeda, Masato Nishimura, Yutaka Ueda, Masako Shida, Kosei Hasegawa, Tsukasa Baba, Sosuke Adachi, Takuhei Yokoyama, Shinya Satoh, Hiroko Machida, Shiori Yanai, Keita Iwasaki, Takahito M Miyake, Satoshi Takeuchi, Munetaka Takekuma, Tadayoshi Nagano, Mayu Yunokawa, Tanja Pejovic, Kohei Omatsu, Mian M K Shahzad, Joseph L Kelley, Frederick R Ueland, Lynda D Roman
OBJECTIVE: To identify risk factors for venous thromboembolism (VTE) and to examine the association of VTE and survival in women with uterine carcinosarcoma. METHODS: This multicenter retrospective study examined 906 women who underwent primary surgical treatment for stage I-IV uterine carcinosarcoma. Time-dependent analyses were performed for cumulative incidence of VTE after surgery on multivariate models. RESULTS: There were 72 (7.9%) women who developed VTE after surgery with 1-, 2-, and 5-year cumulative incidences being 5...
December 13, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29245959/low-concentration-of-formononetin-promotes-proliferation-of-estrogen-receptor-positive-cells-through-an-er%C3%AE-mir-375-pten-erk1-2-bcl-2-pathway
#15
Yan-Hong Guo, Feng-Yan Tang, Yong Wang, Wen-Jun Huang, Jing Tian, Hui-Ling Lu, Min Xin, Jian Chen
A low dose of formononetin accelerates the proliferation of nasopharyngeal carcinoma cells in vitro; however, the underlying mechanism remains unknown. Here, we investigated the molecular mechanism of formononetin in CNE2 cell proliferation. CNE2 cells were treated with 0 to 1 μM formononetin. To inhibit mitogen activated protein kinase / extracellular regulate kinase (MAPK/ERK) kinase (MEK) and microRNA (miR)-375, cells were pretreated with either PD98059 or a miR-375 inhibitor, respectively, followed by co-treatment with formononetin (0...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29245355/endometriosis-associated-malignant-transformation-in-abdominal-surgical-scar-a-prisma-compliant-systematic-review
#16
Anca Mihailovici, Misgav Rottenstreich, Svetlana Kovel, Ilan Wassermann, Noam Smorgick, Zvi Vaknin
BACKGROUND: Endometriosis-associated malignant transformation in abdominal surgical scar (EAMTAS) is a very rare and aggressive phenomenon. Our current article aims to provide a clinical overview, focusing on risk factors affecting survival. METHODS: We performed a Preferred Reporting Items for Systematic Reviews and Meta-Analyses-compliant systematic review based on prior reviews and case reports regarding the phenomenon published as abstracts in English, from January 1980 to November 2016...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29245257/endometrial-stromal-sarcoma-in-combination-with-mixed-type-endometrial-carcinomas-a-case-report-and-literature-review
#17
REVIEW
Xiao-Xin Xiu, Hua-Li Wang, Lv Yun-Yi, Kong Fan-Dou, Hou Jin-Ping
RATIONALE: Endometrial stromal sarcoma (ESS) is rare, representing only approximately 0.2% of all uterine malignancies. Mixed type endometrial carcinomas (MT-ECs) are rare tumors with both type I and II features, and are difficult to diagnose. Cases of ESS and MT-ECs coexisting in the same patient are extremely rare. This study aimed to describe a case of ESS in combination with MT-ECs in a 47-year-old premenopausal woman. PATIENT CONCERNS: A woman presented to the hospital complaining of occasional abdominal pain and had high tumor markers: cancer antigen (CA) 19-9 (263...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29243125/minichromosome-maintenance-complex-component-6-mcm6-expression-correlates-with-histological-grade-and-survival-in-endometrioid-endometrial-adenocarcinoma
#18
Judicaël Hotton, Mikaël Agopiantz, Agnès Leroux, Claire Charra-Brunaud, Béatrice Marie, Hélène Busby-Venner, Olivier Morel, Jean-Louis Guéant, Jean-Michel Vignaud, Shyue-Fang Battaglia-Hsu, Guillaume Gauchotte
Minichromosome maintenance complex component 6 (MCM6) is involved in initiating DNA replication and is upregulated during licensed G0 phase of the cell cycle. This early expression permits its labeling of more proliferating cells than those by Ki-67. Here using a cohort of 89 endometrioid adenocarcinoma, we report findings made on the prognostic value of MCM6 based on immunohistochemical labeling index (LI) of the protein in comparison with that of Ki67 as no such information is currently available. Additionally, we examined the prognostic values of these markers based on their mRNA expression using a cohort of uterine corpus endometrial carcinoma (UCEC, n = 307) taken from The Cancer Genome Atlas (TCGA) database...
December 14, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29239064/case-of-rapidly-progressing-condylomatous-squamous-cell-carcinoma-of-the-uterine-cervix-associated-with-low-risk-human-papillomavirus-type-6
#19
Miho Masuda, Kaoru Abiko, Sachiko Minamiguchi, Ryusuke Murakami, Tsukasa Baba, Ikuo Konishi
Condylomatous, or warty squamous cell carcinoma (SCC) of the uterine cervix, is a rare variant of invasive SCC. Here, we describe a case of aggressive condylomatous SCC of the uterine cervix. A 43-year-old woman was monitored for 3 years for suspected low-grade squamous intraepithelial lesion. A whitish papillary mass occupied the cervix, and the colposcopic diagnosis was condyloma acuminatum. A cervical biopsy revealed papillary proliferating thick squamous epithelium, which consisted of koilocytes and atypical cells with enlarged nuclei...
December 14, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29234950/the-evolution-of-endometrial-carcinoma-classification-through-application-of-immunohistochemistry-and-molecular-diagnostics-past-present-and-future
#20
REVIEW
Emily A Goebel, August Vidal, Xavier Matias-Guiu, C Blake Gilks
Uterine cancer was first subclassified based on anatomic site, separating those tumours arising from the endometrium from cervical cancers. There was then further subclassification of endometrial cancers based on cell type, and this correlated with the Type I and Type II categories identified through the epidemiological studies of Bokhman, with endometrioid carcinoma corresponding (approximately) to Type I and serous carcinoma to Type II. These histotypes are not clearly separable in practice, however, with considerable interobserver variability in histotype diagnosis, especially for high-grade tumours...
December 12, 2017: Virchows Archiv: An International Journal of Pathology
keyword
keyword
53385
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"