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https://www.readbyqxmd.com/read/28708788/therapy-modalities-prognostic-factors-and-outcome-of-the-primary-cervical-carcinosarcoma-meta-analysis-of-extremely-rare-tumor-of-cervix
#1
Gunsu Kimyon Comert, Osman Turkmen, Alper Karalok, Derman Basaran, Dilek Bulbul, Taner Turan
OBJECTIVE: The aim of this study was to evaluate the prognostic factors, treatment options, and survival outcomes of primary carcinosarcomas of the uterine cervix. METHODS: An electronic search of the literature was conducted from 1951 to February 2017 to identify articles on primary cervical carcinosarcoma. After comprehensive evaluation of case series and case reports, 81 cases were included in the study. RESULTS: The most common clinical FIGO (International Federation of Gynecology and Obstetrics) stage was IB at 53% of cases...
July 13, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28706158/significant-benefit-of-nivolumab-treating-pd-l1-positive-metastatic-pulmonary-carcinosarcoma-a-case-report-and-literature-review
#2
Zhe Zhang, Yishan Chen, Mingxia Ma, Junli Hao, Rui Ding, Lixin Han, Jiayun Zou, Lina Zhang, Qin Meng, Xiujuan Qu, Yunpeng Liu, Mingfang Zhao
Immunotherapy has recently become a new focus for the treatment of malignant tumors following the surgery, chemotherapy, radiotherapy, and molecular targeted therapy. Nivolumab, a human monoclonal antibody, is the first programmed cell death protein-1 (PD-1) inhibitor, which can prohibit the interaction of its ligand (PD-L1), restoring the immune response of T cells, and enhancing the recognition of tumor cells by the immune system.Pulmonary Carcinosarcoma is an uncommon but highly aggressive tumor type with a poor prognosis...
July 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28704324/fascin-is-associated-with-aggressive-behavior-and-poor-outcome-in-uterine-carcinosarcoma
#3
Abby M Richmond, Erin A Blake, Kathleen Torkko, Elizabeth E Smith, Monique A Spillman, Miriam D Post
OBJECTIVE: The mechanisms underlying the histogenesis and aggressiveness of uterine carcinosarcoma (UCS) are poorly understood; however, previous studies implicate epithelial-mesenchymal transition (EMT). Fascin is a proinvasive, actin-bundling protein and an important component of EMT. It is associated with poor outcomes in human carcinoma, especially in estrogen receptor (ER)-negative tumors arising in organs normally expressing ER. We sought to evaluate fascin expression in UCS and its relationship to ER status, clinicopathologic indicators of tumor aggressiveness, and survival outcomes...
July 12, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28700435/ifitm1-outperforms-cd10-in-differentiating-low-grade-endometrial-stromal-sarcomas-from-smooth-muscle-neoplasms-of-the-uterus
#4
Aurelia Busca, Previn Gulavita, Carlos Parra-Herran, Shahidul Islam
Distinguishing between uterine neoplasms of smooth muscle and endometrial stromal origin is a frequent diagnostic challenge. We investigated the staining pattern of interferon-induced transmembrane protein-1 (IFITM1), a novel endometrial stromal marker, in endometrial and smooth muscle uterine neoplasms and compared it with CD10 in its ability to differentiate between these two groups. Immunohistochemistry for IFITM1 and CD10 was performed in 20 cases of smooth muscle neoplasms (10 cases leiomyoma, 10 cases leiomyosarcoma), 14 cases of endometrial stromal sarcoma (ESS) (12 cases of low grade and 2 cases of high grade) and 12 cases of carcinosarcoma...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28700425/ultrastaging-of-sentinel-lymph-nodes-in-endometrial-carcinoma-according-to-use-of-2-different-methods
#5
Elizabeth Euscher, Dawen Sui, Pamela Soliman, Shannon Westin, Preetha Ramalingam, Roland Bassett, Anais Malpica
Sentinel lymph node (SLN) sampling may provide staging information without exposing patients to risks of lymph node dissection. There is no consensus protocol for optimal pathologic handling of these specimens. This study compares 2 ultrastaging protocols of SLN in endometrial carcinoma (EC). All SLN were serially sectioned perpendicular to the long axis in 2 mm intervals and entirely submitted for routine hematoxylin and eosin (H&E) processing. SLN negative by routine processing had ultrastaging (US) by one of the following: method 1 (M1), 5 H&E levels at 250 μm intervals with 2 unstained slides at each level; pankeratin immunohistochemistry (IHC) performed on level 1 in cases with negative H&E levels or method 2 (M2), 1 H&E level + 2 unstained slides cut 250 μm into the tissue block; pankeratin IHC performed in cases with negative H&E...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28700424/uterine-carcinosarcomas-clinical-histopathologic-and-immunohistochemical-characteristics
#6
Xiaowei Chen, Rebecca Arend, Diane Hamele-Bena, Ana I Tergas, Melanie Hawver, Guo-Xia Tong, Thomas C Wright, Jason D Wright
Carcinosarcomas (malignant mixed Müllerian tumors or MMMT) are rare malignant tumors in the female genital tract composed of both malignant epithelial and malignant mesenchymal components. They comprise <5% of all neoplasms in the gynecologic tract and have an aggressive clinical course. The purpose of this study is to evaluate the immunophenotype and possible histogenesis of carcinosarcomas of the uterus. Sixty-two cases of uterine carcinosarcomas diagnosed between 1995 and 2011 were retrieved from the gynecologic pathology files at Columbia University Medical Center...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28696169/can-the-apparent-diffusion-coefficient-differentiate-the-grade-of-endometrioid-adenocarcinoma-and-the-histological-subtype-of-endometrial-cancer
#7
Bin Yan, Tingting Zhao, Xiufen Liang, Chen Niu, Caixia Ding
Background Diffusion-weighted imaging (DWI) provides useful information for the identification of benign and malignant uterine lesions. However, the use of the apparent diffusion coefficient (ADC) for histopathological grading of endometrial cancer is controversial. Purpose To explore the use of ADC values in differentiating the preoperative tumor grading of endometrioid adenocarcinomas and investigate the relationship between the ADC values of endometrial cancer and the histological tumor subtype. Material and Methods We retrospectively evaluated 98 patients with endometrial cancers, including both endometrioid adenocarcinomas (n = 80) and non-endometrioid adenocarcinomas (n = 18)...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28684728/a-rare-case-of-sarcomatoid-carcinoma-of-the-lung-with-spine-metastasis-including-a-literature-review
#8
Hafiza Sobia Arshad, Rizwan Ahmed Dudekula, Masooma Niazi, Sandeep Malik, Misbahuddin Khaja
BACKGROUND Sarcomatoid carcinoma is a rare, aggressive, malignant cancer composed of sarcoma and sarcoma-like components, and can occur in different organs such as the thyroid gland, bone, skin, breast, pancreas, liver, urinary tract, and lung. Pulmonary sarcomatoid carcinoma accounts for only a small percentage of lung cancers and has histological variants that include pleomorphic carcinoma, giant cell carcinoma, spindle cell carcinoma, carcinosarcoma, and pulmonary blastoma. CASE REPORT Here, we present a case of sarcomatoid carcinoma in a 63-year-old HIV-positive Hispanic male who presented with back pain, dry cough, and weight loss...
July 7, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28679774/syd985-a-novel-duocarmycin-based-her2-targeting-antibody-drug-conjugate-shows-antitumor-activity-in-uterine-and-ovarian-carcinosarcoma-with-her2-neu-expression
#9
Gulden Menderes, Elena Bonazzoli, Stefania Bellone, Jonathan D Black, Federica Predolini, Francesca Pettinella, Alice Masserdotti, Luca Zammataro, Gary Altwerger, Natalia Buza, Pei Hui, Serena Wong, Babak Litkouhi, Elena Ratner, Dan-Arin Silasi, Masoud Azodi, Peter E Schwartz, Alessandro D Santin
Purpose: Carcinosarcomas (CS) are highly aggressive gynecologic malignancies containing both carcinomatous and sarcomatous elements with heterogeneous HER2/neu expression. We compared the efficacy of SYD985, (Synthon Biopharmaceuticals BV), a novel HER2-targeting antibody-drug conjugate (ADC), to Trastuzumab emtansine (T-DM1, Genentech-Roche) against primary uterine and ovarian CS. <p>Experimental Design: Eight primary CS cell lines were evaluated for HER2/neu surface expression by IHC and gene amplification by FISH assays...
July 5, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28669579/lessons-learnt-from-implementation-of-a-lynch-syndrome-screening-program-for-patients-with-gynaecological-malignancy
#10
Fedaa Najdawi, Ashley Crook, Jayne Maidens, Christopher McEvoy, Andrew Fellowes, Justine Pickett, Musei Ho, David Nevell, Kirsten McIlroy, Amy Sheen, Loretta Sioson, Mahsa Ahadi, John Turchini, Adele Clarkson, Russell Hogg, Sue Valmadre, Greg Gard, Susan J Dooley, Rodney J Scott, Stephen B Fox, Michael Field, Anthony J Gill
Despite a trend towards universal testing, best practice to screen patients presenting with gynaecological malignancy for Lynch syndrome (LS) is uncertain. We report our institutional experience of a co-ordinated gynaecological LS screening program. All patients with endometrial carcinoma or carcinosarcoma, or gynaecological endometrioid or clear cell carcinomas undergo reflex four panel immunohistochemistry (IHC) for MLH1, PMS2, MSH2 and MSH6 followed by cascade somatic hypermethylation analysis of the MLH1 promoter locus for dual MLH1/PMS2 negative tumours...
August 2017: Pathology
https://www.readbyqxmd.com/read/28669452/metaplastic-breast-carcinoma-analysis-of-31-cases-from-a-single-institute
#11
Salah Fayaz, Gerges Attia Demian, Heba El-Sayed Eissa, Henney Amanguno, Sadeq Abuzalouf
PURPOSE: Metaplastic carcinoma of the breast (MBC) accounts for less than 1% of all mammary tumors. This study aimed at revision of the clinico-pathological features, treatment strategy and outcome for MBC patients presented to the Kuwait Cancer Control Center to define the clinical behavior and prognostic factors of these neoplasms in our population. PATIENT AND METHODS: Thirty-one patients were retrieved from our surgical pathology registry between January 2005 and December 2014...
June 29, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28667246/genetic-profile-and-biological-implication-of-pin2-trf1-interacting-telomerase-inhibitor-1-pinx1-in-human-cancers-an-analysis-using-the-cancer-genome-atlas
#12
Wei-Juan Huang, Mei Li, Xiao-Han Jin, Xiao-Jia Huang, Wei Zhao, Xiao-Peng Tian
Pin2/TRF1-interacting telomere inhibitor 1 (PinX1) was originally identified as a telomerase inhibitor, involved in maintaining telomerase activity, telomere length, and chromosomal stability. However, research has shown that PinX1 can have opposing molecular status in its expression patterns in several other tumor types. We thus investigated the genetic profile and biological implication of PinX1 in several human cancers using the cBioportal database. Our results showed that PinX1 deletion accounted for the most alterations, with the frequency of its deletion regularly occurring in pathological types of carcinosarcoma and adenocarcinoma...
June 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28657223/unenhanced-region-on-magnetic-resonance-imaging-represents-tumor-progression-in-uterine-carcinosarcoma
#13
Ayami Inoue, Ken Yamaguchi, Yasuhisa Kurata, Ryusuke Murakami, Kaoru Abiko, Junzo Hamanishi, Eiji Kondoh, Tsukasa Baba, Aki Kido, Ikuo Konishi, Noriomi Matsumura
OBJECTIVE: Carcinosarcoma of the uterine corpus has a poor prognosis. Although pathological necrosis is a prognostic factor of endometrial cancer, the clinicopathological influences of an unenhanced region observed on magnetic resonance imaging (MRI) are inconclusive. The aim of our study was to determine the clinicobiological impact of the presence of an unenhanced region on MRI, which can represent necrosis, in uterine carcinosarcoma. METHODS: The clinicopathological factors of 29 patients diagnosed with uterine carcinosarcoma were assessed retrospectively...
June 1, 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28656498/biphasic-malignant-tumours-of-the-abdominal-cavity
#14
REVIEW
L Max Almond, Adrian T Warfield, Anant Desai, David Gourevitch, Samuel J Ford
Carcinosarcomas (CS) are uncommon, highly aggressive, biphasic tumours consisting of both sarcomatous and carcinomatous elements. They appear to originate from a common cell of origin, either via transformation from a single premature precursor or conversion of a mature epithelial cell through an epithelial-mesenchymal transition. CS should be considered a unique cancer subtype with cells typically displaying diffuse mitotic activity and widespread atypical mitoses predisposing to early metastasis and a tendency to local recurrence following resection...
June 27, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28654573/patterns-of-adjuvant-therapy-utilization-in-uterine-carcinosarcoma-stages-i-to-iii-a-national-cancer-database-analysis
#15
William A Stokes, Tyler P Robin, Matthew W Jackson, Arya Amini, Tracey E Schefter, Carolyn C Lefkowits, Christine M Fisher
OBJECTIVE: The objective of this study is to characterize patterns of utilization of adjuvant chemotherapy (CT) and radiotherapy (RT) in the posthysterectomy management of uterine carcinosarcoma (UCS) in the United States. MATERIALS AND METHODS: We queried the National Cancer Database for women diagnosed with UCS between 2004 and 2012 and undergoing hysterectomy. Logistic regression was performed to identify sociodemographic, facility-specific, and treatment-related predictors of receiving multiagent chemotherapy, external beam radiotherapy (EBRT), or brachytherapy (BT)...
June 26, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28652731/enhanced-antitumor-activity-of-surface-modified-iron-oxide-nanoparticles-and-an-%C3%AE-tocopherol-derivative-in-a-rat-model-of-mammary-gland-carcinosarcoma
#16
Daniel Horák, Vitaliy Igorovych Pustovyy, Andrii Valeriyovich Babinskyi, Olga Mikhailovna Palyvoda, Vasyl Fedorovich Chekhun, Igor Nikolaevich Todor, Oleksandr Ivanovich Kuzmenko
Maghemite (γ-Fe2O3) nanoparticles were obtained by coprecipitation of ferrous and ferric salts in an alkaline medium followed by oxidation; the nanoparticles were coated with poly(N,N-dimethylacrylamide) (PDMA) and characterized by transmission electron microscopy, attenuated total reflection (ATR) Fourier transform infrared (FTIR) spectroscopy, dynamic light scattering, thermogravimetric and elemental analyses, and magnetic measurements in terms of particle morphology, size, polydispersity, amount of coating, and magnetization, respectively...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28637513/sinonasal-teratocarcinosarcoma-a-case-report
#17
Yi Chao Foong, Vince Murdolo, Nusa Naiman, Laura Hepner, Raef Awad
BACKGROUND: Sinonasal teratocarcinosarcoma is a rare and aggressive malignancy with histological features of both carcinosarcoma and teratoma. The optimal management of this malignancy is unclear, with most patients being managed by a combination of surgery and radiotherapy. CASE PRESENTATION: We describe an 83-year-old white woman with sinonasal teratocarcinosarcoma of her left nasal cavity treated with surgical debulking initially with radiological evidence of residual disease which was treated with radiotherapy (60 Gy in 30 fractions)...
June 22, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28630682/overexpressed-prame-is-a-potential-immunotherapy-target-in-sarcoma-subtypes
#18
Jason Roszik, Wei-Lien Wang, John A Livingston, Christina L Roland, Vinod Ravi, Cassian Yee, Patrick Hwu, Andrew Futreal, Alexander J Lazar, Shreyaskumar R Patel, Anthony P Conley
BACKGROUND: PRAME (preferentially expressed antigen in melanoma), a member of the cancer-testis antigen family, has been shown to have increased expression in solid tumors, including sarcoma, and PRAME-specific therapies are currently in development for other cancers such as melanoma. METHODS: To map the landscape of PRAME expression in sarcoma, we used publicly available data from The Cancer Genome Atlas (TCGA) and the Cancer Cell Line Encyclopedia (CCLE) projects and determined which sarcoma subtypes and subsets are associated with increased PRAME expression...
2017: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/28629835/ruthenium-complex-exerts-antineoplastic-effects-that-are-mediated-by-oxidative-stress-without-inducing-toxicity-in-walker-256-tumor-bearing-rats
#19
Carlos Eduardo Alves de Souza, Helen de Morais Alves de Souza, Maria Carolina Stipp, Claudia Rita Corso, Claudia Martins Galindo, Carolina Riverin Cardoso, Rosangela Locatelli Dittrich, Edneia Amancio de Souza Ramos, Giseli Klassen, Rose Maria Carlos, Sílvia Maria Suter Correia Cadena, Alexandra Acco
The present study evaluated the in vivo antitumor effects and toxicity of a new Ru(II) compound, cis-(Ru[phen]2[ImH]2)(2+) (also called RuphenImH [RuC]), against Walker-256 carcinosarcoma in rats. After subcutaneous inoculation of Walker-256 cells in the right pelvic limb, male Wistar rats received 5 or 10mgkg(-1) RuC orally or intraperitoneally (i.p.) every 3 days for 13 days. A positive control group (2mgkg(-1) cisplatin) and negative control group (vehicle) were also used. Tumor progression was checked daily...
June 17, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28626581/carcinosarcoma-of-the-maxillary-sinus-a-rare-case-report
#20
Jawad Hasnaoui, Said Anajar, Mohammed Tatari, Reda Abada, Sami Rouadi, Mohammed Roubal, Mohammed Mahtar
INTRODUCTION: Carcinosarcoma is a highly malignant tumor characterized by dual malignant histologic differentiation of epithelial and mesenchymal components. The tumor is extremely rare in the sinonasal tract, with only 13 cases reported since 1957 in the literature. PRESENTATION OF CASE: We report a case of a 55-year-old man with right-sided face pain revealed a mass in the right maxillary sinus and nasal cavity. A large incisional biopsy from the nasal cavity concluded the diagnosis of carcinosarcoma...
July 2017: Annals of Medicine and Surgery
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