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https://www.readbyqxmd.com/read/27929397/a-p-glycoprotein-is-linked-to-resistance-to-the-bacillus-thuringiensis-cry3aa-toxin-in-a-leaf-beetle
#1
Yannick Pauchet, Anne Bretschneider, Sylvie Augustin, David G Heckel
Chrysomela tremula is a polyvoltine oligophagous leaf beetle responsible for massive attacks on poplar trees. This beetle is an important model for understanding mechanisms of resistance to Bacillus thuringiensis (Bt) insecticidal toxins, because a resistant C. tremula strain has been found that can survive and reproduce on transgenic poplar trees expressing high levels of the Cry3Aa Bt toxin. Resistance to Cry3Aa in this strain is recessive and is controlled by a single autosomal locus. We used a larval midgut transcriptome for C...
December 5, 2016: Toxins
https://www.readbyqxmd.com/read/27914919/expressing-a-moth-abcc2-gene-in-transgenic-drosophila-causes-susceptibility-to-bt-cry1ac-without-requiring-a-cadherin-like-protein-receptor
#2
Tristan Stevens, Sisi Song, John B Bruning, Amanda Choo, Simon W Baxter
Bt toxins ingested by insect pests can bind to midgut receptors and cause death, although several steps in this process remain unclear. Multiple Bt toxin receptors have been identified in Lepidoptera, including a cadherin-like protein (CaLP), which is central to several models explaining Bt toxins' mode of action. Mutations in the Plutella xylostella ATP-dependent binding cassette transporter C2 (Px-abcc2), rather than CaLP, are genetically linked with Bt Cry1Ac resistance. Here we expressed Px-abcc2 in Drosophila and performed larval bioassays to determine whether this protein acts as an effective Bt receptor...
November 30, 2016: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27896932/mesoionic-insecticides-a-novel-class-of-insecticides-that-modulate-nicotinic-acetylcholine-receptors
#3
Caleb W Holyoke, Daniel Cordova, Wenming Zhang, James D Barry, Robert M Leighty, Robert F Dietrich, James J Rauh, Thomas F Pahutski, George P Lahm, My-Hanh Thi Tong, Eric A Benner, John L Andreassi, Rejane M Smith, Daniel R Vincent, Laurie A Christianson, Luis A Teixeira, Vineet Singh, Kenneth A Hughes
BACKGROUND: As the world population grows toward 9 billion by 2050 it is projected that food production will need to increase by 60%. A critical part of this growth includes the safe and effective use of insecticides to reduce the estimated 20-49% loss of global crop yields due to pests. Development of new insecticides will help sustain this protection and overcome insecticide resistance. RESULTS: A novel class of mesoionic compounds has been discovered with exceptional insecticidal activity on a range of Hemiptera and Lepidoptera...
November 29, 2016: Pest Management Science
https://www.readbyqxmd.com/read/27845250/ryanodine-receptor-point-mutations-confer-diamide-insecticide-resistance-in-tomato-leafminer-tuta-absoluta-lepidoptera-gelechiidae
#4
Emmanouil Roditakis, Denise Steinbach, Gerald Moritz, Emmanouil Vasakis, Marianna Stavrakaki, Aris Ilias, Lidia García-Vidal, María Del Rosario Martínez-Aguirre, Pablo Bielza, Evangelia Morou, Jefferson E Silva, Wellington M Silva, Ηerbert A A Siqueira, Sofia Iqbal, Bartlomiej J Troczka, Martin S Williamson, Chris Bass, Anastasia Tsagkarakou, John Vontas, Ralf Nauen
Insect ryanodine receptors (RyR) are the molecular target-site for the recently introduced diamide insecticides. Diamides are particularly active on Lepidoptera pests, including tomato leafminer, Tuta absoluta (Lepidoptera: Gelechiidae). High levels of diamide resistance were recently described in some European populations of T. absoluta, however, the mechanisms of resistance remained unknown. In this study the molecular basis of diamide resistance was investigated in a diamide resistant strain from Italy (IT-GELA-SD4), and additional resistant field populations collected in Greece, Spain and Brazil...
November 12, 2016: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27777010/mesoionic-pyrido-1-2-a-pyrimidinones-a-novel-class-of-insecticides-inhibiting-nicotinic-acetylcholine-receptors
#5
Wenming Zhang, Caleb W Holyoke, James Barry, Robert M Leighty, Daniel Cordova, Daniel R Vincent, Kenneth A Hughes, My-Hanh T Tong, Stephen F McCann, Ming Xu, Twyla A Briddell, Thomas F Pahutski, George P Lahm
A novel class of mesoionic pyrido[1,2-a]pyrimidinones has been discovered with exceptional insecticidal activity controlling a number of insect species, particularly hemiptera and lepidoptera. Mode-of-action studies showed that they act on nicotinic acetylcholine receptors (nAChRs) primarily as inhibitors. Here we report the discovery, evolution, and preparation of this class of chemistry. Our efforts in structure-activity relationship elucidation and biological activity evaluation are also presented.
October 13, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27741298/analysis-of-the-antennal-transcriptome-and-insights-into-olfactory-genes-in-hyphantria-cunea-drury
#6
Long-Wa Zhang, Ke Kang, Shi-Chang Jiang, Ya-Nan Zhang, Tian-Tian Wang, Jing Zhang, Long Sun, Yun-Qiu Yang, Chang-Chun Huang, Li-Ya Jiang, De-Gui Ding
Hyphantria cunea (Drury) (Lepidoptera: Arctiidae) is an invasive insect pest which, in China, causes unprecedented damage and economic losses due to its extreme fecundity and wide host range, including forest and shade trees, and even crops. Compared to the better known lepidopteran species which use Type-I pheromones, little is known at the molecular level about the olfactory mechanisms of host location and mate choice in H. cunea, a species using Type-II lepidopteran pheromones. In the present study, the H...
2016: PloS One
https://www.readbyqxmd.com/read/27698435/sex-pheromone-recognition-and-characterization-of-three-pheromone-binding-proteins-in-the-legume-pod-borer-maruca-vitrata-fabricius-lepidoptera-crambidae
#7
Aping Mao, Jing Zhou, Bin Mao, Ya Zheng, Yufeng Wang, Daiqin Li, Pan Wang, Kaiyu Liu, Xiaoping Wang, Hui Ai
Pheromone-binding proteins (PBPs) are essential for the filtering, binding and transporting of sex pheromones across sensillum lymph to membrane-associated pheromone receptors of moths. In this study, three novel PBP genes were expressed in Escherichia coli to examine their involvement in the sex pheromone perception of Maruca vitrata. Fluorescence binding experiments indicated that MvitPBP1-3 had strong binding affinities with four sex pheromones. Moreover, molecular docking results demonstrated that six amino acid residues of three MvitPBPs were involved in the binding of the sex pheromones...
October 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27638948/trpa5-an-ankyrin-subfamily-insect-trp-channel-is-expressed-in-antennae-of-cydia-pomonella-lepidoptera-tortricidae-in-multiple-splice-variants
#8
Alberto Maria Cattaneo, Jonas Martin Bengtsson, Nicolas Montagné, Emmanuelle Jacquin-Joly, Omar Rota-Stabelli, Umberto Salvagnin, Angela Bassoli, Peter Witzgall, Gianfranco Anfora
Transient receptor potential (TRP) channels are an ancient family of cation channels, working as metabotropic triggers, which respond to physical and chemical environmental cues. Perception of chemical signals mediate reproductive behaviors and is therefore an important target for sustainable management tactics against the codling moth Cydia pomonella L. (Lepidoptera: Tortricidae). However, olfactory behavior strongly depends on diel periodicity and correlation of chemical with physical cues, like temperature, and physical cues thus essentially contribute to the generation of behavioral response...
2016: Journal of Insect Science
https://www.readbyqxmd.com/read/27624654/monitoring-and-mechanisms-of-insecticide-resistance-in-chilo-suppressalis-lepidoptera-crambidae-with-special-reference-to-diamides
#9
Rong Yao, Dan-Dan Zhao, Shuai Zhang, Li-Qi Zhou, Xin Wang, Cong-Fen Gao, Shun-Fan Wu
BACKGROUND: The rice stem borer, Chilo suppressalis Walker (Lepidoptera: Crambidae), is one of the most economically important pests of rice in Asia. Chemical control remains the most efficient primary means for controlling this pest. RESULTS: Significant variations among field populations in their resistance to seven insecticides were observed. The populations exhibited LC50 values that ranged between 0.605 and 108.088 mg AI L(-1) for chlorantraniliprole and between 0...
September 14, 2016: Pest Management Science
https://www.readbyqxmd.com/read/27620558/developmental-expression-of-ecdysone-related-genes-associated-with-metamorphic-changes-during-midgut-remodeling-of-silkworm-bombyx-mori-lepidoptera-bombycidae
#10
Ebru Goncu, Ramazan Uranlı, Gozde Selek, Osman Parlak
Steroid hormone 20-hydroxyecdysone is known as the systemic regulators of insect cells; however, how to impact the fate and function of mature and stem cells is unclear. For the first time, we report ecdysone regulatory cascades in both mature midgut cell and stem cell fractions related to developmental events by using histological, immunohistochemical, biochemical and gene expression analysis methods. Ecdysone receptor-B1 (EcR-B1) and ultraspiracle 1 (USP-1) mRNAs were detected mainly in mature cells during programmed cell death (PCD)...
2016: Journal of Insect Science
https://www.readbyqxmd.com/read/27538507/antennal-transcriptome-analysis-and-expression-profiles-of-odorant-binding-proteins-in-eogystia-hippophaecolus-lepidoptera-cossidae
#11
Ping Hu, Jing Tao, Mingming Cui, Chenglong Gao, Pengfei Lu, Youqing Luo
BACKGROUND: Eogystia hippophaecolus (Hua et al.) (Lepidoptera: Cossidae) is the major threat to seabuckthorn plantations in China. Specific and highly efficient artificial sex pheromone traps was developed and used to control it. However, the molecular basis for the pheromone recognition is not known. So we established the antennal transcriptome of E. hippophaecolus and characterized the expression profiles of odorant binding proteins. These results establish and improve the basis knowledge of the olfactory receptive system, furthermore provide a theoretical basis for the development of new pest control method...
2016: BMC Genomics
https://www.readbyqxmd.com/read/27456115/three-toxins-two-receptors-one-mechanism-mode-of-action-of-cry1a-toxins-from-bacillus-thuringiensis-in-heliothis-virescens
#12
Anne Bretschneider, David G Heckel, Yannick Pauchet
Insecticidal crystal (Cry) proteins from Bacillus thuringiensis (Bt) are highly active against Lepidoptera. However, field-evolved resistance to Bt toxins is on the rise. The 12-cadherin domain protein HevCaLP and the ABC transporter HevABCC2 are both genetically linked to Cry toxin resistance in Heliothis virescens. We investigated their interaction using stably expressing non-lytic clonal Sf9 cell lines expressing either protein or both together. Untransfected Sf9 cells are innately sensitive to Cry1Ca toxin, but not to Cry1A toxins; and quantitative PCR revealed negligible expression of genes involved in Cry1A toxicity such as cadherin, ABCC2, alkaline phosphatase (ALP) and aminopeptidase N (APN)...
September 2016: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27436734/bacillus-thuringiensis-toxin-resistance-mechanisms-among-lepidoptera-progress-on-genomic-approaches-to-uncover-causal-mutations-in-the-european-corn-borer-ostrinia-nubilalis
#13
REVIEW
Brad S Coates
Transgenic plants that express Bacillus thuringiensis (Bt) crystal (Cry) protein toxins (Bt crops) effectively control feeding by the European corn borer, Ostrinia nubilalis, although documented resistance evolution among a number of species in both the laboratory and field has heightened concerns about the durability of this technology. Research has provided major insights into the mutations that alter Bt toxin binding receptor structure and function within the midgut of Lepidoptera that directly impacts the efficacy of Bt toxins, and potentially leads to the evolution of resistance to Bt crops in the field...
June 2016: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/27403935/heritable-genome-editing-with-crispr-cas9-induces-anosmia-in-a-crop-pest-moth
#14
Fotini A Koutroumpa, Christelle Monsempes, Marie-Christine François, Anne de Cian, Corinne Royer, Jean-Paul Concordet, Emmanuelle Jacquin-Joly
Lepidoptera suffer critical lack of genetic tools and heritable genome edition has been achieved only in a few model species. Here we demonstrate that the CRISPR/Cas9 system is highly efficient for genome editing in a non-model crop pest Lepidoptera, the noctuid moth Spodoptera littoralis. We knocked-out the olfactory receptor co-receptor Orco gene to investigate its function in Lepidoptera olfaction. We find that 89.6% of the injected individuals carried Orco mutations, 70% of which transmitted them to the next generation...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27364081/antennal-transcriptome-and-differential-expression-of-olfactory-genes-in-the-yellow-peach-moth-conogethes-punctiferalis-lepidoptera-crambidae
#15
Xiao-Jian Jia, Hai-Xiang Wang, Zeng-Guang Yan, Min-Zhao Zhang, Chun-Hua Wei, Xiao-Chun Qin, Wei-Rong Ji, Patrizia Falabella, Yan-Li Du
The yellow peach moth (YPM), Conogethes punctiferalis (Guenée), is a multivoltine insect pest of crops and fruits. Antennal-expressed receptors are important for insects to detect olfactory cues for host finding, mate attraction and oviposition site selection. However, few olfactory related genes were reported in YPM until now. In the present study, we sequenced and characterized the antennal transcriptomes of male and female YPM. In total, 15 putative odorant binding proteins (OBPs), 46 putative odorant receptors (ORs) and 7 putative ionotropic receptors (IRs) were annotated and identified as olfactory-related genes of C...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27353701/identification-and-expression-profiles-of-neuropeptides-and-their-g-protein-coupled-receptors-in-the-rice-stem-borer-chilo-suppressalis
#16
Gang Xu, Gui-Xiang Gu, Zi-Wen Teng, Shun-Fan Wu, Jia Huang, Qi-Sheng Song, Gong-Yin Ye, Qi Fang
In insects, neuropeptides play important roles in the regulation of multiple physiological processes by binding to their corresponding receptors, which are primarily G protein-coupled receptors (GPCRs). The genes encoding neuropeptides and their associated GPCRs in the rice stem borer Chilo suppressalis were identified by a transcriptomic analysis and were used to identify potential targets for the disruption of physiological processes and the protection of crops. Forty-three candidate genes were found to encode the neuropeptide precursors for all known insect neuropeptides except for arginine-vasopressin-like peptide (AVLP), CNMamide, neuropeptide-like precursors 2-4 (NPLP2-4), and proctolin...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27333791/sequencing-de-novo-assembly-and-annotation-of-a-pink-bollworm-larval-midgut-transcriptome
#17
Erica E Tassone, Gina Zastrow-Hayes, John Mathis, Mark E Nelson, Gusui Wu, J Lindsey Flexner, Yves Carrière, Bruce E Tabashnik, Jeffrey A Fabrick
BACKGROUND: The pink bollworm Pectinophora gossypiella (Saunders) (Lepidoptera: Gelechiidae) is one of the world's most important pests of cotton. Insecticide sprays and transgenic cotton producing toxins of the bacterium Bacillus thuringiensis (Bt) are currently used to manage this pest. Bt toxins kill susceptible insects by specifically binding to and destroying midgut cells, but they are not toxic to most other organisms. Pink bollworm is useful as a model for understanding insect responses to Bt toxins, yet advances in understanding at the molecular level have been limited because basic genomic information is lacking for this cosmopolitan pest...
2016: GigaScience
https://www.readbyqxmd.com/read/27279336/identification-and-tissue-expression-profile-of-genes-from-three-chemoreceptor-families-in-an-urban-pest-periplaneta-americana
#18
Yan Chen, Ming He, Zhao-Qun Li, Ya-Nan Zhang, Peng He
Periplaneta americana is a notorious urban pest prevalent in human habitats; very little is known about its chemosensory mechanism. Employing the advanced next-generation sequencing technique, in the present study, we conducted transcriptome sequencing and analysis of the antennae of the adult males and females as well as their mouthparts using an Illumina platform. This resulted in the discovery of a huge number of the members of all major known chemosensory receptor families in P. americana, including 96 odorant receptors (ORs), 53 ionotropic receptors (IRs), and 33 gustatory receptors (GRs)...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27265820/mutation-g275e-of-the-nicotinic-acetylcholine-receptor-%C3%AE-6-subunit-is-associated-with-high-levels-of-resistance-to-spinosyns-in-tuta-absoluta-meyrick-lepidoptera-gelechiidae
#19
Wellington M Silva, Madeleine Berger, Chris Bass, Martin Williamson, Danielle M N Moura, Lílian M S Ribeiro, Herbert A A Siqueira
The tomato leafminer, Tuta absoluta, now a major pest of tomato crops worldwide, is primarily controlled using chemical insecticides. Recently, high levels of resistance to the insecticide spinosad have been described in T. absoluta populations in Brazil. Selection of a resistant field-collected strain led to very high levels of resistance to spinosad and cross-resistance to spinetoram, but not to other insecticides that target the nicotinic acetylcholine receptor (nAChR). In this study the mechanisms underlying resistance to spinosad were investigated using toxicological, biochemical and molecular approaches...
July 2016: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/27228010/gustatory-receptors-in-lepidoptera-chemosensation-and-beyond
#20
REVIEW
A R Agnihotri, A A Roy, R S Joshi
Lepidoptera is one of the most widespread insect orders and includes several agriculturally important insect species. Ecological success of the lepidopteran insects partly depends on their adaptive chemoreception tactics, which play an important role in the selection of hosts, egg-laying sites and mates. Members of the G-protein coupled receptor family, gustatory receptors (GRs), are an integral part of the Lepidoptera chemosensory machinery. They are expressed in chemosensory neurones and are known to detect different environmental stimuli...
October 2016: Insect Molecular Biology
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