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https://www.readbyqxmd.com/read/28098864/victor-vinflunine-in-advanced-metastatic-transitional-cell-carcinoma-of-the-urothelium-a-retrospective-analysis-of-the-use-of-vinflunine-in-multi-centre-real-life-setting-as-second-line-chemotherapy-through-free-of-charge-programme-for-patients-in-the-uk-and
#1
Syed A Hussain, Jawaher Ansari, Robert Huddart, Derek G Power, Jeanette Lyons, James Wylie, Maria Vilarino-Varlela, Nils O Elander, Rhona McMenemin, Lisa M Pickering, Guy Faust, Seema Chauhan, Richard J Jackson
There is no standard of care in the UK or Ireland for second-line chemotherapy for patients with advanced transitional cell carcinoma (TCCU). Vinflunine is approved for TCCU patients who have failed a platinum-based regimen, and is standard of care in Europe but is not routinely available in the UK. Data were collected retrospectively on patients who received vinfluine as a second-line treatment. The aims were to document the toxicity and efficacy in a real life setting. Data were collected on 49 patients from 9 sites across the UK and Ireland [median age, 64 (IQR, 57-70) years, 33 males]...
January 13, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28098502/united-kingdom-national-paediatric-bilateral-project-results-of-professional-rating-scales-and-parent-questionnaires
#2
H E Cullington, D Bele, J C Brinton, S Cooper, M Daft, J Harding, N Hatton, J Humphries, M E Lutman, J Maddocks, J Maggs, K Millward, G O'Donoghue, S Patel, K Rajput, V Salmon, T Sear, A Speers, A Wheeler, K Wilson
OBJECTIVES: This fourteen-centre project used professional rating scales and parent questionnaires to assess longitudinal outcomes in a large non-selected population of children receiving simultaneous and sequential bilateral cochlear implants. METHODS: This was an observational non-randomized service evaluation. Data were collected at four time points: before bilateral cochlear implants or before the sequential implant, one year, two years, and three years after...
January 18, 2017: Cochlear Implants International
https://www.readbyqxmd.com/read/28098255/annual-time-series-analysis-of-aqueous-edna-reveals-ecologically-relevant-dynamics-of-lake-ecosystem-biodiversity
#3
Iliana Bista, Gary R Carvalho, Kerry Walsh, Mathew Seymour, Mehrdad Hajibabaei, Delphine Lallias, Martin Christmas, Simon Creer
The use of environmental DNA (eDNA) in biodiversity assessments offers a step-change in sensitivity, throughput and simultaneous measures of ecosystem diversity and function. There remains, however, a need to examine eDNA persistence in the wild through simultaneous temporal measures of eDNA and biota. Here, we use metabarcoding of two markers of different lengths, derived from an annual time series of aqueous lake eDNA to examine temporal shifts in ecosystem biodiversity and in an ecologically important group of macroinvertebrates (Diptera: Chironomidae)...
January 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28098051/chronic-fatigue-syndrome-cognitive-behavioural-and-emotional-processing-vulnerability-factors
#4
Samantha K Brooks, Trudie Chalder, Katharine A Rimes
BACKGROUND: Cognitive-behavioural models of chronic fatigue syndrome (CFS) suggest that personality factors such as perfectionism and high moral standards may contribute to the development of CFS. AIMS: To investigate cognitive, behavioural and emotional processing risk factors for CFS. METHOD: CFS patients (n = 67) at a UK specialist clinic completed questionnaires about psychological characteristics both currently and retrospectively (6 months pre-CFS onset)...
January 18, 2017: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/28098003/cervical-cancer
#5
Lisa Berry
Essential facts In the UK in 2013 there were about 3,200 new cases of cervical cancer. It is the 12th most common cancer in UK women, resulting in 890 deaths in 2014. Deaths in England are more common in women living in the most deprived areas.
January 18, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28098001/charity-enlists-nurses-to-tackle-loneliness-in-older-people
#6
(no author information available yet)
An Age UK pilot programme involving nurses is helping to combat loneliness in older people, early findings show.
January 18, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28097999/after-54-years-in-nhs-nursing-assistant-celebrates-her-80th-birthday-at-work
#7
(no author information available yet)
One of the UK's oldest nursing assistants celebrated her 80th birthday with a party at work.
January 18, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28097998/fast-track-course-halves-three-year-nursing-degree
#8
Stephanie Jones-Berry
A fast-track nursing degree course in north east England, aimed at addressing the UK's nurse shortage, will take on new students in March.
January 18, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28097975/uk-may-face-shortfall-of-36-000-nurses-by-2030
#9
Petra Kendall-Raynor
The UK faces a potential shortage of more than 36,000 nurses by 2030, a new study has shown.
January 18, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28097904/estimated-burden-of-cardiovascular-disease-and-value-based-price-range-for-evolocumab-in-a-high-risk-secondary-prevention-population-in-the-us-payer-context
#10
Peter P Toth, Mark Danese, Guillermo Villa, Yi Qian, Anne Beaubrun, Armando Lira, Jeroen P Jansen
AIM: To estimate real-world cardiovascular disease (CVD) burden and value-based price range of evolocumab for a US-context, high-risk, secondary-prevention population. MATERIALS AND METHODS: Burden of CVD was assessed using the UK-based Clinical Practice Research Datalink (CPRD) in order to capture complete CV burden including CV mortality. Patients on standard of care (SOC; high-intensity statins) in CPRD were selected based on eligibility criteria of FOURIER, a phase 3 CV outcomes trial of evolocumab, and categorized into 4 cohorts: high-risk prevalent atherosclerotic CVD (ASCVD) cohort (N = 1448), acute coronary syndrome (ACS) (N = 602), ischemic stroke (IS) (N = 151), and heart failure (HF) (N = 291) incident cohorts...
January 18, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28097760/benefits-of-quitting-smoking-on-work-productivity-and-activity-impairment-in-the-united-states-the-european-union-and-china
#11
Christine L Baker, Natalia M Flores, Kelly H Zou, Marianna Bruno, Vannessa J Harrison
BACKGROUND: Smoking has important health and economic consequences for individuals and society. This study expands the understanding of work-related burden associated with smoking and benefit of smoking cessation across the US, European Union (EU) and China using large-scale, representative survey methodology. METHODS: Data utilised the 2013 National Health and Wellness Survey in United States (US), EU5 (UK, France, Germany, Italy, and Spain) and China. Working-aged respondents 18-64 were used in the analyses (US N=58 500; EU5 N=50 417; China N=17 987) and were categorised into: current smokers, trying to quit, former smokers and never smokers...
January 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28097438/attitudes-towards-fever-amongst-uk-paediatric-intensive-care-staff
#12
Thomas Brick, Rachel S Agbeko, Patrick Davies, Peter J Davis, Akash Deep, Peter-Marc Fortune, David P Inwald, Amy Jones, Richard Levin, Kevin P Morris, John Pappachan, Samiran Ray, Shane M Tibby, Lyvonne N Tume, Mark J Peters
: The role played by fever in the outcome of critical illness in children is unclear. This survey of medical and nursing staff in 35 paediatric intensive care units and transport teams in the United Kingdom and Ireland established attitudes towards the management of children with fever. Four hundred sixty-two medical and nursing staff responded to a web-based survey request. Respondents answered eight questions regarding thresholds for temperature control in usual clinical practice, indications for paracetamol use, and readiness to participate in a clinical trial of permissive temperature control...
January 18, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28097428/goal-formulation-and-tracking-in-child-mental-health-settings-when-is-it-more-likely-and-is-it-associated-with-satisfaction-with-care
#13
Jenna Jacob, Davide De Francesco, Jessica Deighton, Duncan Law, Miranda Wolpert, Julian Edbrooke-Childs
Goal formulation and tracking may support preference-based care. Little is known about the likelihood of goal formulation and tracking and associations with care satisfaction. Logistic and Poisson stepwise regressions were performed on clinical data for N = 3757 children from 32 services in the UK (M age = 11; SDage = 3.75; most common clinician-reported presenting problem was emotional problems = 55.6%). Regarding the likelihood of goal formulation, it was more likely for pre-schoolers, those with learning difficulties or those with both hyperactivity disorder and conduct disorder...
January 18, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28097406/the-uk-experience-of-promoting-dementia-recognition-and-management-in-primary-care
#14
Steve Iliffe, Jane Wilcock
BACKGROUND: The early and timely recognition of dementia syndrome is a policy imperative in many countries. In the UK the achievement of earlier and timelier recognition has been pursued through educational interventions, incentivisation of general practitioners and the promotion of a network of memory clinics. OBJECTIVE: The effectiveness of education, incentivisation and memory clinic activity are unknown. This article analyses data from different sources to evaluate the impact of these interventions on the incidence and prevalence of dementia, and the diagnostic performance of memory clinics...
January 17, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28097244/minimising-costs-in-spinal-surgery-is-group-save-testing-justified-in-lumbar-decompression-surgery
#15
William T Wilson, Adam M H Young, Paul Fivey
BACKGROUND: Lumbar microdiscectomy and laminectomy are two of the most common neurosurgical procedures performed worldwide. Current practice still sees pre-operative group and save testing prior to this surgery. The aim of this study was to determine the need for pre-operative group and save and post-operative blood checks. METHODS: Patient archives were reviewed to identify those undergoing primary elective lumbar decompression surgery at the Institute of Neurological Sciences, Queen Elizabeth University Hospital, Glasgow, UK...
December 2016: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/28097118/femur-neck-fracture-in-a-young-marfan-syndrome-patient
#16
Yong-Uk Kwon, Gyu-Min Kong, Jun-Ho Park
Marfan syndrome is an autosomal dominant and could decrease bone mineral density. So patients with Marfan syndrome could vulnerable to trauma in old ages. We present the first report, to the best of our knowledge, of a rare fracture of the femoral neck with a minor traumatic history in a juvenile Marfan syndrome patient whose physis is still open. Although the patient is young, her bone mineral density was low and the geometry of femur is changed like old ages. The femur neck fracture in children is very rare and only caused by high energy trauma, we concluded that the Marfan syndrome makes the bone weaker in young age and preventative medications to avoid fractures in younger Marfan syndrome patients are necessary in early ages...
December 2016: Hip & Pelvis
https://www.readbyqxmd.com/read/28097039/the-concept-of-wind-in-traditional-chinese-medicine
#17
REVIEW
Mehrab Dashtdar, Mohammad Reza Dashtdar, Babak Dashtdar, Karima Kardi, Mohammad Khabaz Shirazi
The use of folk medicine has been widely embraced in many developed countries under the name of traditional, complementary and alternative medicine (TCAM) and is now becoming the mainstream in the UK and the rest of Europe, as well as in North America and Australia. Diversity, easy accessibility, broad continuity, relatively low cost, base levels of technological inputs, fewer side effects, and growing economic importance are some of the positive features of folk medicine. In this framework, a critical need exists to introduce the practice of folk medicine into public healthcare if the goal of reformed access to healthcare facilities is to be achieved...
December 2016: Journal of Pharmacopuncture
https://www.readbyqxmd.com/read/28097016/smoking-treatment-optimisation-in-pharmacies-stop-a-cluster-randomised-pilot-trial-of-a-training-intervention
#18
V W Madurasinghe, Ratna Sohanpal, Wai James, Liz Steed, Sandra Eldridge, Sjc Taylor, C Griffiths, Robert Walton
BACKGROUND: UK government policy aims to strengthen the role of community pharmacies in health promotion. Thus, we conducted feasibility studies for an intervention to enhance delivery of the NHS Smoking Cessation Service. METHODS: The overall aims were to assess acceptability and feasibility of conducting the intervention in community pharmacies and piloting this with a cluster randomised trial. Specific objectives were (1) to estimate likely participation rates of pharmacies and stop smoking advisors, (2) to establish the potential impact of the training intervention on throughput and retention of smokers in smoking services, (3) to establish potential impact on smoking cessation outcomes, (4) to optimise logistics for conducting a cluster randomised trial in the next phase of the research programme and (5) to consider the feasibility of collecting pharmacy and service user data...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28096974/mortality-hospital-days-and-treatment-costs-of-current-and-reduced-sugar-consumption-in-israel
#19
Gary M Ginsberg
BACKGROUND: Consumption of sugar causes tooth decay, overweight and obesity related morbidities. This paper in response to the Minister of Health's request, provides estimates of the mortality, morbidity and health care costs attributable to sugar consumption in Israel along with the effects of reducing sugar consumption. METHODS: Gender specific relative risks of many diseases from overweight (25 < =BMI < 30) and obesity (BMI > =30) were applied to the national gender specific prevalence rates of overweight and obesity in order to calculate the population attributable fraction (PAF) from overweight and obesity...
2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/28096705/situational-judgment-tests-reliably-measure-professional-attributes-important-for-clinical-practice
#20
EDITORIAL
Katie Petty-Saphon, Kim A Walker, Fiona Patterson, Vicki Ashworth, Helena Edwards
Over the course of more than 40 years, international research has consistently shown situational judgment tests (SJTs) to be a reliable and valid selection method for assessing a range of professional attributes. However, SJTs still represent a relatively new selection method within the medical profession, and as such it is to be expected that applicant reactions will vary. In this Expert Opinion piece, we respond to Najim et al's article "The situational judgement test: a student's worst nightmare" by highlighting three key clarifications...
2017: Advances in Medical Education and Practice
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