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https://www.readbyqxmd.com/read/28930879/repeat-effort-performance-is-reduced-24-h-following-acute-dehydration-in-mixed-martial-arts-athletes
#1
Oliver R Barley, Fiona Iredale, Dale W Chapman, Amanda Hopper, Chris Abbiss
This study sought to determine the influence of acute dehydration on physical performance and physiology in Mixed Martial Arts (MMA). MMA athletes (n=14; age: 23±4 years), completed in a randomised counterbalanced order a dehydration protocol, (DHY: 3 h cycling at 60 W in 40°C to induce 5% dehydration) or thermoneutral control (25°C: CONT) exercise, followed by ad libitum fluid/food intake. Performance testing (a repeat sled push test, medicine ball chest throw and vertical jump) was completed 3 and 24 h following the intervention, while urine and blood samples were collected before, 20 min, 3 and 24 h following the intervention...
September 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28930874/the-effectiveness-of-fish-oil-supplementation-in-attenuating-exercise-induced-muscle-damage-in-females-during-mid-follicular-and-mid-luteal-menstrual-phases
#2
Sarah K McKinley-Barnard, Thomas L Andre, Josh J Gann, Paul S Hwang, Darryn S Willoughby
The purpose of this study was to determine if the differences in estrogen levels during the female menstrual cycle and fish oil supplementation would attenuate eccentric exercise-induced muscle damage (EIMD) and delayed onset muscle soreness (DOMS). In a double-blind fashion, 22 physically-active females (20.9 ± 1.4 years, 63.5 ± 9.0 kg, 165.2 ± 7.5 cm) were randomly assigned to ingest either 6 grams of fish oil (n = 11) or placebo (n = 11) daily for 21 days. Participants underwent an eccentric exercise bout of the knee extensors on two occasions during the mid-follicular (MF) and mid-luteal (ML) phases of the 28-day menstrual cycle...
September 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28930447/ultra-sensitive-quantitation-of-plasma-membrane-proteins-via-isrta
#3
Tao Gao, Bei Wang, Liu Shi, Xiaoli Zhu, Yang Xiang, Jun-Ichi Anzai, Genxi Li
Quantitation of plasma membrane proteins (PMPs) are fundamental and frequently performed in the daily lab-work. However, challenged by inherent/interacted hetero-structures and complex surroundings of the PMPs in lipid membrane, quantitative techniques for PMP often require complex treatments (e.g. labelling, isolation, purification, and determination), and the sensitivity is usually not satisfactory. To address the problem, we have proposed a novel method that enables quantitation of PMPs with extremely high sensitivity, in an easier-to-manipulate and more streamlined way...
September 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28930362/rapid-development-of-specialty-population-registries-and-quality-measures-from-electronic-health-record-data-an-agile-framework
#4
Vaishnavi Kannan, Jason S Fish, Jacqueline M Mutz, Angela R Carrington, Ki Lai, Lisa S Davis, Josh E Youngblood, Mark R Rauschuber, Kathryn A Flores, Evan J Sara, Deepa G Bhat, DuWayne L Willett
BACKGROUND: Creation of a new electronic health record (EHR)-based registry often can be a "one-off" complex endeavor: first developing new EHR data collection and clinical decision support tools, followed by developing registry-specific data extractions from the EHR for analysis. Each development phase typically has its own long development and testing time, leading to a prolonged overall cycle time for delivering one functioning registry with companion reporting into production. The next registry request then starts from scratch...
June 14, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28930339/controlled-electrochemical-doping-of-graphene-based-3d-nanoarchitecture-electrodes-for-supercapacitors-and-capacitive-deionisation
#5
A M Abdelkader, D J Fray
Chemically-doped graphenes are promising electrode materials for energy storage and electrosorption applications. Here, an affordable electrochemical green process is introduced to dope graphene with nitrogen. The process is based on reversing the polarity of two identical graphene oxide (GO) electrodes in molten KCl-LiCl-Li3N. During the cathodic step, the oxygen functional groups on the GO surface are removed through direct electro-deoxidation reactions or a reaction with the deposited lithium. In the anodic step, nitrogen is adsorbed onto the surface of graphene and subsequently reacts to form nitrogen-doped graphene...
September 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28930152/proteomic-analysis-of-the-chlorophyta-dunaliella-new-strain-al-1-revealed-global-changes-of-metabolism-during-high-carotenoid-production
#6
Faten Ben Amor, Fatma Elleuch, Hajer Ben Hlima, Matthieu Garnier, Bruno Saint-Jean, Mohamed Barkallah, Chantal Pichon, Slim Abdelkafi, Imen Fendri
The green microalgae Dunaliella genus is known for the production of high added value molecules. In this study, strain AL-1 was isolated from the Sebkha of Sidi El Hani (Sousse, Tunisia). This isolate was identified both morphologically and genetically via 18S rRNA gene sequence as a member of the genus Dunaliella. Strain AL-1 was found to be closely related to Dunaliella salina, Dunaliella quartolecta and Dunaliella polymorpha with more than 97% similarity. Response surface methodology was used to maximize carotenoid production by strain AL-1 by optimizing its growth conditions...
September 20, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28929961/-national-antimicrobial-resistance-surveillance-system-namrss-external-quality-assessment-studies-2011-2016
#7
Serap Süzük Yıldız, Hüsniye Şimşek, Nilay Çöplü, Zeynep Gülay
Establishment of sustainable and evidence-based surveillance systems are recommended for prevention of microbial resistance by the World Health Organization (WHO). As a necessity of these surveillance systems, participants are recommended to implement an external quality assessment (EQA) program. In this scope, National Antimicrobial Resistance Surveillance System (NARSS) has been established within the Public Health Institute of Turkey (PHIT) in our country since 2011. In the scope of this surveillance, NARSS EQA program has been implemented in a cycle per year and four isolates were sent to participants per cycle every year since 2011...
July 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28929732/highly-durable-self-standing-solid-state-supercapacitor-based-on-an-ionic-liquid-rich-ionogel-and-porous-carbon-nanofiber-electrodes
#8
Silas K Simotwo, Parameswara Rao Chinnam, Stephanie L Wunder, Vibha Kalra
A high-performance, self-standing solid-state supercapacitor is prepared by incorporating an ionic liquid (IL)-rich ionogel made with 95 wt % IL (1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide) and 5 wt % methyl cellulose, a polymer matrix, into highly interconnected 3-D activated carbon nanofiber (CNF) electrodes. The ionogel exhibits strong mechanical properties with a storage modulus of 5 MPa and a high ionic conductivity of 5.7 mS cm(-1) at 25 °C. The high-surface-area CNF-based electrode (2282 m(2) g(-1)), obtained via an electrospinning technique, exhibits hierarchical porosity generated both in situ during pyrolysis and ex situ via KOH activation...
September 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28929599/rutile-tio2-mesocrystals-as-a-novel-sulfur-host-for-high-performance-lithium-sulfur-batteries
#9
Qingqing Sun, Kaixiang Chen, Yubin Liu, Yafeng Li, Mingdeng Wei
Although Lithium-sulfur (Li-S) batteries are one of the most promising rechargeable batteries in energy storage devices, the poor cycling performance of Li-S batteries restricts their potential application. The polar materials can improve the cycling stability due to their inherent strong chemical interaction with polysulfides. Herein, a novel rutile TiO2 mesocrystals (RTMs) was employed as the host of sulfur in Li-S, displaying a stable cycling performance with a capacity retention of 64% and a small average capacity decay rate of 0...
September 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28929363/all-in-one-low-intensity-pulsed-ultrasound-stimulation-system-using-piezoelectric-micromachined-ultrasonic-transducer-pmut-arrays-for-targeted-cell-stimulation
#10
Wonjun Lee, Seungjun Yoo, Joontaek Jung, Woojin Kang, Wei Wang, Cheil Moon, Hongsoo Choi
A novel cell-stimulation system was fabricated using 10 × 29 piezoelectric micromachined ultrasonic transducer (pMUT) arrays for targeted ultrasonic cell stimulation. Both the diameter of a single pMUT element and the edge-to-edge gap were 120 μm, and the size of a pMUT array was 2.27 × 6.84 mm, to be placed at the bottom of a Transwell. The measured resonance frequency of a single pMUT element was 1.48 ± 0.13 MHz and the measured acoustic intensity of the pMUT array was 0.15 ± 0.03 MPa at 1 mm away from the transducer...
September 19, 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28929286/e-waste-management-and-sustainability-a-case-study-in-brazil
#11
Luís Peres Azevedo, Fernando Gabriel da Silva Araújo, Carlos Alberto Ferreira Lagarinhos, Jorge Alberto Soares Tenório, Denise Crocce Romano Espinosa
The advancement of technology and development of new electronic and electrical equipment with a reduced life cycle has increased the need for the disposal of them (called Waste of Electric and Electronic Equipment or simply e-waste) due to defects presented during use, replacement of obsolete equipment, and ease of acquisition of new equipment. There is a lack of consumer awareness regarding the use, handling storage, and disposal of this equipment. In Brazil, the disposal of post-consumer waste is regulated by the National Solid Waste Policy, established by Law No...
September 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28928862/discovering-the-mir-26a-5p-targetome-in-prostate-cancer-cells
#12
Milena Rizzo, Gabriele Berti, Francesco Russo, Sofia Fazio, Monica Evangelista, Romina D'Aurizio, Marco Pellegrini, Giuseppe Rainaldi
Purpose. miR-26a-5p is a tumor suppressor (TS) miRNA often downregulated in several tumor tissues and tumor cell lines. In this work, we performed the re-expression of the miR-26a-5p in DU-145 prostate cancer cells to collect genes interacting with miR-26a-5p and analyzed their integration in the tumorigenesis related pathways. Methods. The transfection of DU-145 prostate cancer cells with miR-26a-5p was done using nucleofection. The biological effects induced by miR-26a-5p re-expression were detected with routine assays for cell proliferation, cell cycle, survival, apoptosis and cell migration...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28928841/lung-cancer-requires-multidisciplinary-treatment-to-improve-patient-survival-a-case-report
#13
Aldo Pezzuto, Fabrizio Terzo, Maria Laura Graziani, Alberto Ricci, Pierdonato Bruno, Salvatore Mariotta
The present study reports two cases of lung cancer with the involvement of the pleura. The diagnosis of adenocarcinoma with epidermal growth factor receptor (EGFR) mutation was made following repeated thoracentesis with cytology of pleural fluid and thoracoscopy with pleural biopsies. Talc pleurodesis was successfully performed in both cases subsequent to diagnosis. Following talc pleurodesis, the first patient (62 years old; male; non-smoker) underwent 3 cycles of cisplatin/vinorelbine chemotherapy, with a poor response...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28928794/mechanistic-model-for-cancer-growth-and-response-to-chemotherapy
#14
Eman Simbawa
Cancer treatment has developed over the years; however not all patients respond to this treatment, and therefore further research is needed. In this paper, we employ mathematical modeling to understand the behavior of cancer and its interaction with therapy. We study a drug delivery and drug-cell interaction model along with cell proliferation. Due to the fact that cancer cells grow when there are enough nutrients and oxygen, proliferation can be a barrier against a response to therapy. To understand the effect of this factor, we perform numerical simulations of the model for different values of the parameters with a continuous delivery of the drug...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28928782/comparison-of-microleakage-of-scotchbond%C3%A2-universal-adhesive-with-methacrylate-resin-in-class-v-restorations-by-two-methods-swept-source-optical-coherence-tomography-and-dye-penetration
#15
Hamid Kermanshah, Hossein Khorsandian
BACKGROUND: One of the most important factors in restoration failure is microleakage at the restoration interface. Furthermore, a new generation of bonding, Scotchbond Universal (multi-mode adhesive), has been introduced to facilitate the bonding steps. The aim of this study was to compare the microleakage of Class V cavities restored using Scotchbond™ Universal with Scotchbond Multi-Purpose in two procedures. MATERIALS AND METHODS: Eighteen freshly extracted human molars were used in this study...
July 2017: Dental Research Journal
https://www.readbyqxmd.com/read/28928434/the-effect-of-frozen-thawed-embryo-transfer-performed-concurrently-with-hysteroscopy-on-the-reproductive-outcomes-during-assisted-reproductive-treatments
#16
Xiuxian Zhu, Hongjuan Ye, Yonglun Fu
The uterine environment is vital to the successful conception; recently, hysteroscopy was used to remove uterine anomalies in patients undergoing assisted reproductive treatments in combination with a "freeze-all" strategy. However, the rapid recurrence of uterine anomalies impose a negative impact on pregnancy. A possible way to avoid this issue is to implement frozen-thawed embryo transfer (FET) as soon as possible. Thus, we sought to investigate the impact of performing FET concurrently with hysteroscopy in the same mense on the pregnancy outcome...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28928401/metabolic-shift-in-sugars-and-amino-acids-regulates-sprouting-in-saffron-corm
#17
Jayram Bagri, Anupama Yadav, Khalid Anwar, Jeremy Dkhar, Sneh Lata Singla-Pareek, Ashwani Pareek
Saffron is one of the most expensive spices of the world. Since this spice is triploid and meiosis is unusual, it cannot reproduce sexually like other plants; rather, it is propagated vegetatively via an underground corm, which can withstand a long dry dormant period before sprouting. Thus, corms are indispensable to saffron propagation. To identify and analyse signature metabolites associated with the 'dormancy-sprouting' process, non-targeted GC-MS was performed at different stages of corm development. Comparative metabolite profiling reflected dissimilar profiles among the stages as portrayed by differential cluster patterns of metabolites in the PCA and PLS-DA analysis...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28928162/therapeutic-drug-monitoring-of-carboplatin-in-high-dose-protocol-ti-ce-for-advanced-germ-cell-tumors-pharmacokinetic-results-of-a-phase-2-multicenter-study
#18
Sotheara Moeung, Christine Chevreau, Sophie Broutin, Jérôme Guitton, Bénédicte Lelièvre, Joseph Ciccolini, Christophe Massard, Aude Fléchon, Rémy Delva, Gwenaëlle Gravis, Jean-Pierre Lotz, Jacques-Olivier Bay, Marine Gross-Goupil, Angelo Paci, Sabrina Marsili, Laurence Malard, Etienne Chatelut, Fabienne Thomas
PURPOSE: We aimed to evaluate the performance of therapeutic drug monitoring (TDM) approach in controlling inter-patient variability of carboplatin exposure (AUC) in patients treated with TI-CE high-dose chemotherapy for advanced germ cell tumors and to assess the possibility of using a formula-based dosing method as a possible alternative. EXPERIMENTAL DESIGN: Eighty nine patients receiving carboplatin for 3 consecutive days during 3 cycles were evaluable for pharmacokinetic study...
September 19, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28928040/p-3f-a-microtubule-polymerization-inhibitor-enhances-p53-stability-through-the-change-in-localization-of-rps27a
#19
Huai Wang, Jiang Feng, Tong Zhou, Lijun Wei, Jianming Zhou
Previously, we demonstrated that P-3F, a podophyllum derivative, exhibits a 297-fold enhancement in antitumor activity than VP-16, used as anticancer agent in clinical. The purpose of our present study was to investigate the precise antitumor mechanism action of P-3F. It showed that P-3F inhibited microtubule polymerization in a concentration-dependent manner. The results were in overall agreement with modeling and docking studies performed on P-3F and tubulin. In addition, P-3F increased the levels of P53, this in turn prolonged P53 half-life...
September 16, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28927810/biogenic-arsenic-volatilisation-from-an-acidic-fen
#20
Jen-How Huang, Liyan Tian, Gunter Ilgen
To quantify arsenic (As) volatilisation by peatlands and to elucidate the environmental factors governing As volatilisation, a series of anoxic incubations with acidic fen soil collected in northeast Bavaria in Germany were performed at 15°C for 4months. Arsenic volatilisation summed to 2.32ng As in the control, which was 1.6% and ~0.01% of the porewater As and the total As storage in the fen soil, respectively. Treatment with 10mM NaN3 resulted in only 0.03ng As volatilisation. In comparison, addition of 10mM NaOAc stimulated microbial activity in fen soil and As volatilisation rose to 8...
September 16, 2017: Science of the Total Environment
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