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https://www.readbyqxmd.com/read/27909746/brain-glutamate-in-anorexia-nervosa-a-magnetic-resonance-spectroscopy-case-control-study-at-7-tesla
#1
Beata R Godlewska, Alexandra Pike, Ann L Sharpley, Agnes Ayton, Rebecca J Park, Philip J Cowen, Uzay E Emir
RATIONALE: Anorexia nervosa (AN) is a serious psychiatric disorder with high morbidity and mortality. There are no established pharmacological treatments and the neurobiology of the condition is poorly understood. Previous studies using magnetic resonance spectroscopy (MRS) have shown that AN may be associated with reductions in indices of brain glutamate; however, at conventional field strengths (≤3 T), it is difficult to separate glutamate from its precursor and metabolite, glutamine...
December 1, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27908411/boron-supplementation-improves-bone-health-of-non-obese-diabetic-mice
#2
Renata Dessordi, Adriano Levi Spirlandeli, Ariane Zamarioli, José Batista Volpon, Anderson Marliere Navarro
Diabetes Mellitus is a condition that predisposes a higher risk for the development of osteoporosis. The objective of this study was to investigate the influence of boron supplementation on bone microstructure and strength in control and non-obese diabetic mice for 30days. The animals were supplemented with 40μg/0,5ml of boron solution and controls received 0,5ml of distilled water daily. We evaluated the biochemical parameters: total calcium, phosphorus, magnesium and boron; bone analysis: bone computed microtomography, and biomechanical assay with a three point test on the femur...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27908005/occurrence-and-stability-of-chimera-states-in-coupled-externally-excited-oscillators
#3
Dawid Dudkowski, Yuri Maistrenko, Tomasz Kapitaniak
We studied the phenomenon of chimera states in networks of non-locally coupled externally excited oscillators. Units of the considered networks are bi-stable, having two co-existing attractors of different types (chaotic and periodic). The occurrence of chimeras is discussed, and the influence of coupling radius and coupling strength on their co-existence is analyzed (including typical bifurcation scenarios). We present a statistical analysis and investigate sensitivity of the probability of observing chimeras to the initial conditions and parameter values...
November 2016: Chaos
https://www.readbyqxmd.com/read/27908000/on-synchronization-in-power-grids-modelled-as-networks-of-second-order-kuramoto-oscillators
#4
J M V Grzybowski, E E N Macau, T Yoneyama
This work concerns analytical results on the role of coupling strength in the phenomenon of onset of complete frequency locking in power-grids modelled as a network of second-order Kuramoto oscillators. Those results allow estimation of the coupling strength for the onset of complete frequency locking and to assess the features of network and oscillators that favor synchronization. The analytical results are evaluated using an order parameter defined as the normalized sum of absolute values of phase deviations of the oscillators over time...
November 2016: Chaos
https://www.readbyqxmd.com/read/27907868/purification-of-high-purity-glycyrrhizin-from-licorice-using-hydrophilic-interaction-solid-phase-extraction-coupled-with-preparative-reversed-phase-liquid-chromatography
#5
Wenyi Yu, Hongli Jin, Aijin Shen, Liang Deng, Jianlian Shi, Xingya Xue, Yadong Guo, Yanfang Liu, Xinmiao Liang
Glycyrrhizin (GA), a major bioactive compound in licorice, has been extensively used throughout the world as a medicine to treat chronic viral hepatitis and allergic dermatitis. In this study, a new method based on hydrophilic interaction solid phase extraction (HILIC-SPE) and preparative reversed-phase liquid chromatography (prep-RPLC) was developed to purify GA with high purity from the complex licorice extract. Via evaluation of retention behavior of GA and flavonoids in different commercially available columns, a hydrophilic column--Click XIon was finally chosen for the purification due to its excellent resolution toward GA and flavonoids under HILIC mode...
November 23, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27906984/balance-and-muscle-strength-in-elderly-women-who-dance-samba
#6
Marcos Maurício Serra, Angelica Castilho Alonso, Mark Peterson, Luis Mochizuki, Júlia Maria D'Andréa Greve, Luiz Eugênio Garcez-Leme
Considering the growth of the aging population, and the increasing risk for falls and related morbidity, it is vital to seek efficient, comprehensive, and culturally relevant prevention programs for elderly people to reduce risks for falls. The aim of the present study was to evaluate the postural balance and muscle strength among women participating in the "Wing of Baianas" in the carnival parades. One hundred and ten women, with an average age of 67.4±5.9 years, were divided into two groups: Baianas group-elderly participants of the carnival parades in the "Wing of Baianas", and a Control group of women who do not dance samba...
2016: PloS One
https://www.readbyqxmd.com/read/27906473/tensile-comparison-of-polydioxanone-polyglyconate-and-barbed-glycolide-trimethylene-carbonate-suture-in-canine-cadaveric-tensor-fascia-lata
#7
Naomi Shimizu, John Tarlton, Ed Friend, Ivan Doran, Kevin Parsons
OBJECTIVE: To compare the mode of failure, load at yield, ultimate load to failure and stiffness of non-barbed polydioxanone, non-barbed polyglyconate and barbed glycolide-trimethylene carbonate (GTC) suture in canine cadaveric fascia. STUDY DESIGN: Ex vivo biomechanical study. SAMPLE POPULATION: 18 fascia lata specimens from 9 canine cadavers. METHODS: 6 fascia lata specimens were sutured with polydioxanone, 6 with polyglyconate, and 6 with barbed GTC suture...
December 1, 2016: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/27906050/the-sh3-and-cysteine-rich-domain-3-stac3-gene-is-important-to-growth-fiber-composition-and-calcium-release-from-the-sarcoplasmic-reticulum-in-postnatal-skeletal-muscle
#8
Xiaofei Cong, Jonathan Doering, Davi A G Mazala, Eva R Chin, Robert W Grange, Honglin Jiang
BACKGROUND: The SH3 and cysteine-rich domain 3 (Stac3) gene is specifically expressed in the skeletal muscle. Stac3 knockout mice die perinatally. In this study, we determined the potential role of Stac3 in postnatal skeletal muscle growth, fiber composition, and contraction by generating conditional Stac3 knockout mice. METHODS: We disrupted the Stac3 gene in 4-week-old male mice using the Flp-FRT and tamoxifen-inducible Cre-loxP systems. RESULTS: RT-qPCR and western blotting analyses of the limb muscles of target mice indicated that nearly all Stac3 mRNA and more than 70 % of STAC3 protein were deleted 4 weeks after tamoxifen injection...
April 11, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27904965/chitosan-hydrogel-microspheres-an-effective-covalent-matrix-for-crosslinking-of-soluble-dextranase-to-increase-stability-and-recycling-efficiency
#9
Faiza Shahid, Afsheen Aman, Muhammad Asif Nawaz, Asad Karim, Shah Ali Ul Qader
Dextranase is a unique biocatalyst that has high specificity and stereo-selectivity towards a complex biopolymer known as dextran. Dextranase has wide industrial application, but most of the time harsh environmental conditions adversely affect the functionality and stability of the enzyme. To overcome this issue, a covalent cross-linking immobilization method was adapted in the current study utilizing a nontoxic and biocompatible matrix known as chitosan. Chitosan hydrogel microspheres were synthesized using chitosan which exhibited noteworthy physical and mechanical strength...
November 30, 2016: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/27904800/cervical-contribution-to-functional-shoulder-impingement-two-case-reports
#10
Steven Pheasant
BACKGROUND: Subacromial impingement is a common condition among overhead athletes. The cause of subacromial impingement can be multifactorial and often involves impaired rotator cuff function. CASE DESCRIPTION: The following cases outline the presentation, examination and intervention of two overhead athletes, a high school football quarterback and a collegiate swimmer, each presenting with signs and symptoms of subacromial impingement. The unique feature in each case was the manifestation of the cervical spine as the apparent source of rotator cuff weakness, which contributed to functional subacromial impingement although other overt signs of cervical or associated nerve root involvement were absent...
December 2016: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/27904519/mind-conduct-disorders-in-children-with-poor-oral-hygiene-habits-and-attention-deficit-hyperactivity-disorder-in-children-with-excessive-tooth-decay
#11
Onur Burak Dursun, Fatih Şengül, İbrahim Selçuk Esin, Tevfik Demirci, Nermin Yücel, Mehmet Melih Ömezli
INTRODUCTION: Dental caries and poor oral hygiene are among the major childhood public health problems. Although dental research frequently refers to the link between these conditions and behavioural issues, little attention has been paid to understanding the reason for oral health problems from a psychiatric point of view. The aim of this study was to examine the relationship between poor oral health and hygiene and parental attitudes towards child rearing, parents' and children's oral hygiene behaviours, and childhood psychiatric disorders...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27904030/formulation-optimization-and-in-vitro-characterization-of-orally-disintegrating-films-using-a-factorial-design-and-mathematical-modeling-for-drug-release
#12
Yeongbin Lee, Prakash Thapa, Seong Hoon Jeong, Mi Hee Woo, Du Hyung Choi
Even though experimental designs are becoming popular especially for conventional dosage forms, limited studies have been performed to optimize formulations of orally disintegrating films (ODFs). This study aimed to evaluate sildenafil citrate-loaded ODFs for a controlled release with hydroxypropyl methylcellulose as a film-forming polymer. A factorial design was utilized for optimization with three control factors: ethanol ratio, plasticizer ratio, and the type of plasticizer. Tensile strength, disintegration time, water contact angle, and thickness were chosen as responses...
November 30, 2016: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27903730/network-patterns-associated-with-navigation-behaviors-are-altered-in-aged-nonhuman-primates
#13
James R Engle, Christopher J Machado, Michele R Permenter, Julie A Vogt, Andrew P Maurer, Alicia M Bulleri, Carol A Barnes
: The ability to navigate through space involves complex interactions between multiple brain systems. Although it is clear that spatial navigation is impaired during aging, the networks responsible for these altered behaviors are not well understood. Here, we used a within-subject design and [(18)F]FDG-microPET to capture whole-brain activation patterns in four distinct spatial behaviors from young and aged rhesus macaques: constrained space (CAGE), head-restrained passive locomotion (CHAIR), constrained locomotion in space (TREADMILL), and unconstrained locomotion (WALK)...
November 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27902895/pathogeny-of-fatigued-walking-condition-in-pekin-ducks
#14
M J Da Costa, E O Oviedo-Rondón, M Wineland, D Jeffrey
Fatigued walking condition (FWC) in ducks is an important welfare and processing issue during the loading/unloading to the processing plant that can be related to heart and bone development. An experiment was conducted to evaluate the effects of incubation conditions on duck embryo bone and heart development and their subsequent effects on ducks showing FWC at market age. Four groups of 2500 Pekin duck eggs were subjected to combinations of two incubation temperature profiles (elevated [E] and normal [N]) and two eggshell conductance profiles (G) (reduced [GR] and normal [GN])...
December 2016: Avian Diseases
https://www.readbyqxmd.com/read/27902841/dynamical-effects-of-calcium-sensitive-potassium-currents-on-voltage-and-calcium-alternans
#15
Matthew Kennedy, Donald M Bers, Nipavan Chiamvimonvat, Daisuke Sato
Cardiac alternans is a precursor to life-threatening arrhythmias. Alternans can be caused by instability of the membrane voltage (Vm ), instability of the intracellular Ca (Cai ) cycling, or both. Vm dynamics and Cai dynamics are coupled via Ca-sensitive currents. In cardiac myocytes, there are several Ca-sensitive potassium (K) currents such as the slowly activating delayed rectifier current (IKs ) and the small conductance Ca-activated potassium (SK) current (ISK ). However, the role of these currents in the development of arrhythmias is not well understood...
November 30, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27902168/biomechanical-comparison-of-pullout-strengths-of-five-cortical-screw-types-an-innovative-measurement-method
#16
Ahmet Karakaşlı, Nihat Acar, Mehmet Hilal Özcanhan, Fatih Ertem
OBJECTIVES: This study aims to assess five different cortical screw types using artificial femurs, under equated testing conditions. MATERIALS AND METHODS: We investigated the maximum force needed to cause deformation at screw-bone interface using fourth generation composite femurs by conducting separate pullout tests for each screw type. We normalized obtained results with traditional methods and cross-comparison. To conduct pullout tests dependent on screw dimensions, we eliminated the effect of bicortical bone thickness by equalizing the conditions of screw insertion...
December 2016: Eklem Hastalıkları Ve Cerrahisi, Joint Diseases & related Surgery
https://www.readbyqxmd.com/read/27901359/buprenorphine-transdermal-system-utilization
#17
Laura Wallace, Aditi Kadakia
OBJECTIVES: To evaluate utilization patterns in patients initiating buprenorphine transdermal system (BTDS), CIII, and estimate the proportion decreasing their total opioid dose over time. METHODS: This retrospective cohort study used data from the Truven Health Analytics MarketScan® Commercial Claims and Encounters Database from January 1, 2011 through December 31, 2015. Eligible individuals were adults aged 18-64 years newly dispensed BTDS (index prescription) who had at least six months of insurance coverage prior to (baseline period) and following (study period) the index prescription...
November 30, 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27900312/posterior-tibial-tendon-displacement-behind-the-tibia-and-its-interposition-in-an-irreducible-isolated-ankle-dislocation-a-case-report-and-literature-review
#18
Alessandro Ortolani, Roberto Bevoni, Alessandro Russo, Maurilio Marcacci, Mauro Girolami
Isolated posteromedial ankle dislocation is a rare condition thanks to the highly congruent anatomical configuration of the ankle mortise, in which the medial and lateral malleoli greatly reduce the rotational movement of the talus, and the strength of the ligaments higher than the malleoli affords protection against fractures. However, other factors, like medial malleolus hypoplasia, laxity of the ligaments, peroneal muscle weakness and previous ankle sprains, could predispose to pure dislocation. In the absence of such factors, only a complex high-energy trauma, with a rotational component, can lead to this event...
July 2016: Joints
https://www.readbyqxmd.com/read/27899894/moderate-load-eccentric-exercise-a-distinct-novel-training-modality
#19
REVIEW
Hans Hoppeler
Over the last 20 years a number of studies have been published using progressive eccentric exercise protocols on motorized ergometers or similar devices that allow for controlled application of eccentric loads. Exercise protocols ramp eccentric loads over an initial 3 weeks period in order to prevent muscle damage and delayed onset muscle soreness. Final training loads reach 400-500 W in rehabilitative settings and over 1200 W in elite athletes. Training is typically carried out three times per week for durations of 20-30 min...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27898384/passivity-and-output-synchronization-of-complex-dynamical-networks-with-fixed-and-adaptive-coupling-strength
#20
Jin-Liang Wang, Huai-Ning Wu, Tingwen Huang, Shun-Yan Ren, Jigang Wu
This paper considers a complex dynamical network model, in which the input and output vectors have different dimensions. We, respectively, investigate the passivity and the relationship between output strict passivity and output synchronization of the complex dynamical network with fixed and adaptive coupling strength. First, two new passivity definitions are proposed, which generalize some existing concepts of passivity. By constructing appropriate Lyapunov functional, some sufficient conditions ensuring the passivity, input strict passivity and output strict passivity are derived for the complex dynamical network with fixed coupling strength...
November 24, 2016: IEEE Transactions on Neural Networks and Learning Systems
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