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https://www.readbyqxmd.com/read/29331974/what-are-the-physical-and-psychological-health-effects-of-suicide-bereavement-on-family-members-an-observational-and-interview-mixed-methods-study-in-ireland
#1
Ailbhe Spillane, Karen Matvienko-Sikar, Celine Larkin, Paul Corcoran, Ella Arensman
OBJECTIVES: Research focussing on the impact of suicide bereavement on family members' physical and psychological health is scarce. The aim of this study was to examine how family members have been physically and psychologically affected following suicide bereavement. A secondary objective of the study was to describe the needs of family members bereaved by suicide. DESIGN: A mixed-methods study was conducted, using qualitative semistructured interviews and additional quantitative self-report measures of depression, anxiety and stress (DASS-21)...
January 13, 2018: BMJ Open
https://www.readbyqxmd.com/read/29325603/culture-conditions-affect-ca2-release-in-artificially-activated-mouse-and-human-oocytes
#2
Yuechao Lu, Davina Bonte, Minerva Ferrer-Buitrago, Mina Popovic, Jitesh Neupane, Margot Van der Jeught, Luc Leybaert, Petra De Sutter, Björn Heindryckx
Inconsistent fertilisation and pregnancy rates have been reported by different laboratories after application of ionomycin as a clinical method of assisted oocyte activation (AOA) to overcome fertilisation failure. Using both mouse and human oocytes, in the present study we investigated the effects of ionomycin and Ca2+ concentrations on the pattern of Ca2+ release and embryonic developmental potential. In the mouse, application of 5μM ionomycin in potassium simplex optimisation medium (KSOM) or 10µM ionomycin in Ca2+-free KSOM significantly reduced the Ca2+ flux and resulted in failure of blastocyst formation compared with 10μM ionomycin in KSOM...
January 12, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29325578/effects-of-a-peer-led-walking-in-schools-intervention-the-wish-study-on-physical-activity-levels-of-adolescent-girls-a-cluster-randomised-pilot-study
#3
Angela Carlin, Marie H Murphy, Alan Nevill, Alison M Gallagher
BACKGROUND: School-based interventions may be effective at increasing levels of physical activity (PA) among adolescents; however, there is a paucity of evidence on whether walking can be successfully promoted to increase PA in this age group. This pilot study aimed to assess the effects of a 12-week school-based peer-led brisk walking programme on levels of school-time PA post intervention. METHODS: Female participants, aged 11-13 years, were recruited from six post-primary schools in Northern Ireland...
January 11, 2018: Trials
https://www.readbyqxmd.com/read/29324588/both-%C3%AE-1-antitrypsin-z-phenotypes-and-low-caeruloplasmin-levels-are-over-represented-in-alcohol-and-nonalcoholic-fatty-liver-disease-cirrhotic-patients-undergoing-liver-transplant-in-ireland
#4
El-Gaily A El-Rayah, Patrick J Twomey, Eleanor M Wallace, Peter A McCormick
OBJECTIVES: Alcoholic liver disease and nonalcoholic fatty liver disease (NAFLD) are steatotic liver diseases and major causes of cirrhosis. Only a minority of patients with risk factors develop cirrhosis and genetic cofactors may be important in pathogenesis. Mutations in the Wilson's and α-1-antitrypsin genes are not uncommon and we speculated that they may act as cofactors. METHODS: We investigated α-1-antitrypsin phenotyes and caeruloplasmin levels in patients undergoing elective liver transplantation...
January 10, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29324318/a-feasibility-study-of-a-multidimensional-breastfeeding-support-intervention-in-ireland
#5
Goiuri Alberdi, Elizabeth J O'Sullivan, Helena Scully, Niamh Kelly, Regina Kincaid, Rosie Murtagh, Stephanie Murray, Denise McGuinness, Ashamole Clive, Mary Brosnan, Lucille Sheehy, Elizabeth Dunn, Fionnuala M McAuliffe
BACKGROUND: Breastfeeding is the optimum mode of infant feeding. Despite this, most global populations do not achieve the World Health Organisation's recommendation of exclusive breast milk for the first 6 months of life. Irish breastfeeding rates are among the lowest in Europe, necessitating a well-designed breastfeeding-support intervention. AIM: To evaluate the feasibility and acceptability of a multidimensional breastfeeding intervention in a rural and an urban maternity setting in Ireland...
December 24, 2017: Midwifery
https://www.readbyqxmd.com/read/29322295/correction-to-epidemiology-of-chronic-hepatitis-b-virus-in-ireland-using-routinely-collected-surveillance-and-administrative-data-2004-2014
#6
Caroline E van Gemert, Niamh Murphy, Tara A Mitchell, Margaret E Hellard, Lelia Thornton
The original version contained a mistake. The published version of this article incorrectly lists Lelia Thornton as Thornton Thornton. The correct author name is presented above.
January 10, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29320900/societal-costs-of-multiple-sclerosis-in-ireland
#7
Peter Carney, Derek O'Boyle, Aidan Larkin, Chris McGuigan, Killian O'Rourke
AIMS: This paper evaluates the impact of multiple sclerosis (MS) in Ireland and estimates the associated direct, indirect, and intangible costs to society based on a large nationally representative sample. MATERIALS AND METHODS: A questionnaire was developed to capture the demographics, disease characteristics, healthcare use, informal care, employment, and wellbeing. Referencing international studies, standardised survey instruments were included (e.g., CSRI, MFIS-5, EQ-5D) or adapted (EDSS) for inclusion in an online survey platform...
January 10, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29317213/influence-of-strain-origin-on-osmoregulatory-and-endocrine-parameters-of-two-non-native-strains-of-atlantic-salmon-salmo-salar-l
#8
Benoît Bernard, Kevin Chantung Sobandi, Veerle Darras, Xavier Rollin, Syaghalirwa N M Mandiki, Patrick Kestemont
Non-native strains of Atlantic salmon are used in reinstatement trials where populations are extinct. Environmental cues like photoperiod and temperature are known to influence the smolting process and there is evidence of strain-, stock- or population-specific differences associated with seaward migration or smoltification. The objective of this study was to compare morphological, osmoregulatory and endorcrine features between two strains, one originating from a cold and short river in Ireland (Cong) and another from a long and warm river in France (Loire-Allier), reared under Belgian conditions in order to highlight major differences in restocking adaptability...
January 6, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29315354/implications-of-guidelines-for-osteoporosis-and-its-treatment
#9
Stephen Tuck, Elizabeth A Little, Terry J Aspray
The development of clinical guidelines is now a more uniform process, with formalised methods to ensure that recommendations are based on current best available evidence from randomised controlled trials and systematic reviews. Over the past 20 years we have seen a growth in guidelines including those relating to osteoporosis, with recommendations varying between and within countries. Some guidelines are concerned with case finding and primary or secondary prevention, such as those produced by the National Institute for Health and Care Excellence (NICE CG146, TA-160, -161, -464), while others focus on specific conditions or risk factors associated with osteoporosis, such as the menopause, coeliac disease and eating disorder...
January 5, 2018: Age and Ageing
https://www.readbyqxmd.com/read/29315005/what-we-do-the-hynes-pharyngoplasty-deep-prevertebrae-stitch
#10
Thessa R Friebel, Paul Morris, Guy Thorburn
The Hynes pharyngoplasty is the second most often performed procedure for velopharyngeal insufficiency in the United Kingdom and Ireland. A crucial step of the procedure is reliable fixation of the flaps onto the posterior pharynx wall. We prefer to fix the flaps to the prevertebral fascia. By using a manually straightened needle and a skin hook, in our hands, placement of this stitch can be made easier and faster.
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29314600/the-febs-journal-in-2018-putting-a-bit-of-color-in-your-life-and-your-figures
#11
EDITORIAL
Seamus J Martin
Seamus Martin holds the Smurfit Chair of Medical Genetics at the Smurfit Institute of Genetics, Trinity College Dublin, Ireland. He works on all aspects of cell death control and is especially interested in the links between cell death, cell stress and inflammation. He received the GlaxoSmithKline Award of The Biochemical Society (2006) and The RDS-Irish Times Boyle Medal (2015) for his work on the role of caspases in apoptosis and was elected to the Royal Irish Academy in 2006 and EMBO in 2009. He is the Editor-in-Chief of The FEBS Journal since 2014...
January 2018: FEBS Journal
https://www.readbyqxmd.com/read/29313156/frequency-of-self-reported-concussion-amongst-professional-and-semi-professional-footballers-in-ireland-during-the-2014-season-a-cross-sectional-study
#12
Nicola Coffey, Martin Lawless, Seamus Kelly, Conor Buggy
BACKGROUND: This paper examines the occupational risk of concussion amongst professional and semi-professional footballers in Ireland during the 2014 League of Ireland season. As part of a broader nationally representative study examining occupational safety and health (OSH) awareness amongst professional footballers, this empirical quantitative study, utilising a convenience sample is the first and largest investigation of the frequency of, and attitudes towards, concussion and concussion reporting amongst Irish senior professional and semi-professional footballers...
January 8, 2018: Sports Medicine—Open
https://www.readbyqxmd.com/read/29311001/up-to-date-and-projected-estimates-of-survival-for-people-with-cystic-fibrosis-using-baseline-characteristics-a-longitudinal-study-using-uk-patient-registry-data
#13
Ruth H Keogh, Rhonda Szczesniak, David Taylor-Robinson, Diana Bilton
BACKGROUND: Cystic fibrosis (CF) is the most common inherited disease in Caucasians, affecting around 10,000 individuals in the UK today. Prognosis has improved considerably over recent decades with ongoing improvements in treatment and care. Providing up-to-date survival predictions is important for patients, clinicians and health services planning. METHODS: Flexible parametric survival modelling of UK CF Registry data from 2011 to 2015, capturing 602 deaths in 10,428 individuals...
January 5, 2018: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29310679/enhancing-recruitment-using-teleconference-and-commitment-contract-erutecc-study-protocol-for-a-randomised-stepped-wedge-cluster-trial-within-the-effects-trial
#14
Erik Lundström, Eva Isaksson, Per Wester, Ann-Charlotte Laska, Per Näsman
BACKGROUND: Many randomised controlled trials (RCTs) fail to meet their recruitment goals in time. Trialists are advised to include study recruitment strategies within their trials. EFFECTS is a Swedish, academic-led RCT of fluoxetine for stroke recovery. The trial's primary objective is to investigate whether 20 mg fluoxetine daily compared with placebo for 6 months after an acute stroke improves the patient's functional outcome. The first patient was included on 20 October 2014 and, as of 31 August 2017, EFFECTS has included 810 of planned 1500 individuals...
January 8, 2018: Trials
https://www.readbyqxmd.com/read/29310521/survey-of-surgeons-regarding-prophylactic-antibiotic-use-in-inguinal-hernia-repair
#15
A P MacCormick, J A Akoh
PURPOSE: The use of prophylactic antibiotics in the mesh repair of inguinal hernias remains controversial. The aim of this study was to determine the perception of surgeons about surgical site infection and how this affects their clinical practice. METHODS: A SurveyMonkey of general surgeons and senior surgical trainees was conducted via the local trust network and the questionnaire was displayed on the website of the Association of Surgeons of Great Britain and Ireland and Association of Surgeons in Training...
January 1, 2018: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/29309369/incidence-and-outcomes-for-patients-with-cirrhosis-admitted-to-the-united-kingdom-critical-care-units
#16
Mark J W McPhail, Francesca Parrott, Julia A Wendon, David A Harrison, Kathy A Rowan, William Bernal
OBJECTIVE: To assess the epidemiology and outcome of patients with cirrhosis following critical care unit admission. DESIGN: Retrospective cohort study. SETTING: Critical care units in England, Wales, and Northern Ireland participating in the U.K. Intensive Care National Audit and Research Centre Case Mix Programme. PATIENTS: Thirty-one thousand three hundred sixty-three patients with cirrhosis identified of 1,168,650 total critical care unit admissions (2...
January 5, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29306739/impact-of-enquiry-based-learning-ebl-on-student-midwife-praxis
#17
Anita Byrne, Jennifer McNeill, Katherine Rogers, Sam Porter
Midwifery training in Ireland moved to Higher Education in 2006. This shift established a physical and educational separation of theory and practice. The adoption of Enquiry Based Learning (EBL) by one Irish midwifery education institution attempted to address this division. Enquiry Based Learning (EBL) has the potential to develop student reflexivity and evidence assimilation across the career-span and may therefore enhance student praxis. EBL has been championed as an example of an educational model that supports praxis, helping to create competent practitioners through the use of authentic learning scenarios that address the theory practice divide...
December 28, 2017: Midwifery
https://www.readbyqxmd.com/read/29305406/early-population-based-outcomes-of-infants-born-with-congenital-diaphragmatic-hernia
#18
Anna-May Long, Kathryn J Bunch, Marian Knight, Jennifer J Kurinczuk, Paul D Losty
PURPOSE: This study aims to describe short-term outcomes of live-born infants with congenital diaphragmatic hernia (CDH) and to identify prognostic factors associated with early mortality. DESIGN: A prospective population cohort study was undertaken between April 2009 and September 2010, collecting data on live-born infants with CDH from all 28 paediatric surgical centres in the UK and Ireland using an established surgical surveillance system. Management and outcomes are described...
January 4, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29304837/process-evaluation-for-optibirth-a-randomised-controlled-trial-of-a-complex-intervention-designed-to-increase-rates-of-vaginal-birth-after-caesarean-section
#19
Patricia Healy, Valerie Smith, Gerard Savage, Mike Clarke, Declan Devane, Mechthild M Gross, Sandra Morano, Deirdre Daly, Susanne Grylka-Baeschlin, Jane Nicoletti, Marlene Sinclair, Rebekah Maguire, Margaret Carroll, Cecily Begley
BACKGROUND: Complex interventions encompassing several interconnecting and interacting components can be challenging to evaluate. Examining the underlying trial processes while an intervention is being tested can assist in explaining why an intervention was effective (or not). This paper describes a process evaluation of a pan-European cluster randomised controlled trial, OptiBIRTH (undertaken in Ireland, Italy and Germany), that successfully used both quantitative and qualitative methods to enhance understanding of the underlying trial mechanisms and their effect on the trial outcome...
January 5, 2018: Trials
https://www.readbyqxmd.com/read/29304782/prevalence-of-bovine-viral-diarrhoea-virus-bvdv-bovine-herpes-virus-1-bhv-1-leptospirosis-and-neosporosis-and-associated-risk-factors-in-161-irish-beef-herds
#20
Damien Barrett, Mervyn Parr, John Fagan, Alan Johnson, Jamie Tratalos, Francis Lively, Michael Diskin, David Kenny
BACKGROUND: There are limited data available, in Ireland or elsewhere, to determine the extent of exposure to various endemic diseases among beef cows and factors associated with exposure to causative pathogens. The objectives of this study were to determine the herd and within herd prevalence of Bovine Viral Diarrhoea Virus (BVDV), Bovine Herpes Virus 1 (BHV-1), Leptospirosis and Neosporosis in a large scale study of commercial beef herds on the island of Ireland, and to examine herd level factors associated with exposure to these pathogens in these herds...
January 6, 2018: BMC Veterinary Research
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