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JOURNAL ARTICLE
Karen Dennehy, Amy Lynch, Catriona Reddin, Bart Daly, Tim Dukelow, Michelle Canavan, Maria Costello, Robert Murphy
PURPOSE: Comprehensive geriatric assessment (CGA) is the cornerstone of high-quality care for older adults. There is no current gold standard to guide what should be included as the baseline measure for CGAs. We examined what metrics are being captured in CGA baseline assessments completed by community based integrated care teams in Ireland. METHODS: CGA's care pathways in Ireland are usually initiated with a written document that establish patients baseline in various assessment areas...
April 22, 2024: European Geriatric Medicine
#2
JOURNAL ARTICLE
M Joyce, M Kells, D Flynn, S Wall, E Boylan, L Dunne
Sustainability of DBT programmes and the factors which potentially influence this has received little attention from researchers. In this article, we review the literature reporting on sustainability of DBT programmes in outpatient settings. We also seek to advance the limited knowledge on this topic by reporting on the sustainability of DBT programmes delivered by teams that trained via a coordinated implementation approach in Ireland. As part of this perspective piece we conducted a systematic literature search which identified four studies reporting on DBT programme sustainability...
April 22, 2024: Irish Journal of Psychological Medicine
#3
JOURNAL ARTICLE
Rosalba Miceli, Hanna Eriksson, Giuseppe Lo Russo, Salvatore Alfieri, Maria Moksnes Bjaanæs, Filippo Pietrantonio, Loris De Cecco, Arsela Prelaj, Claudia Proto, Johan Franzén, Deirdre McDonnell, José Javier Berenguer Pina, Teresa Beninato, Laura Mazzeo, Patrizia Giannatempo, Elena Verzoni, John Crown, Åslaug Helland, Alexander Eustace
BACKGROUND: Immune checkpoint inhibitors (ICIs) have significantly improved outcomes in various cancers. ICI treatment is associated with the incidence of immune-related adverse events (irAEs) which can affect any organ. Data on irAEs occurrence in relation to sex- differentiation and their association with gender-specific factors are limited. AIMS: The primary objective of the G-DEFINER study is to compare the irAEs incidence in female and male patients who undergo ICI treatment...
April 21, 2024: Acta Oncologica
#4
JOURNAL ARTICLE
Tomás Barry, Alice Kasemiire, Martin Quinn, Conor Deasy, Gerard Bury, Siobhan Masterson, Ricardo Segurado, Andrew W Murphy
AIM: To explore potential predictors of national out-of-hospital cardiac arrest (OHCA) survival, including health system developments and the COVID pandemic in Ireland. METHODS: National level OHCA registry data from 2012 through to 2020, relating to unwitnessed, and bystander witnessed OHCA were interrogated. Logistic regression models were built by including predictors through stepwise variable selection and enhancing the models by adding pairwise interactions that improved fit...
June 2024: Resuscitation plus
#5
Chase M Kayrouz, Kendra A Ireland, Vanessa Ying, Katherine M Davis, Mohammad R Seyedsayamdost
Selenium is an essential micronutrient, but its presence in biology has been limited to protein and nucleic acid biopolymers. The recent identification of the first biosynthetic pathway for selenium-containing small molecules suggests that there is a larger family of selenometabolites that remains to be discovered. Using a bioinformatic search strategy that relies on mapping of composite active site motifs, we identify a recently evolved branch of abundant and uncharacterized metalloenzymes that we predict are involved in selenometabolite biosynthesis...
April 10, 2024: bioRxiv
#6
JOURNAL ARTICLE
(no author information available yet)
BACKGROUND: The highest priority uncertainty for people with symptomatic cerebral cavernous malformation is whether to have medical management and surgery or medical management alone. We conducted a pilot phase randomised controlled trial to assess the feasibility of addressing this uncertainty in a definitive trial. METHODS: The CARE pilot trial was a prospective, randomised, open-label, assessor-blinded, parallel-group trial at neuroscience centres in the UK and Ireland...
April 17, 2024: Lancet Neurology
#7
JOURNAL ARTICLE
Kathleen T Fitzgerald, Ciara Lyons, Andrew England, Mark F McEntee, Annemarie Devine, Theresa O'Donovan, Eleanor O'Sullivan
BACKGROUND AND PURPOSES: To assess osteoradionecrosis (ORN) incidence in a population of Irish Head and Neck cancer (HNC) patients, and assess precipitating factors that may contribute to ORN development to aid prevention. MATERIALS AND METHODS: Review of 1050 HNC patients attending the Dental Oncology Clinic, CUDSH between 2010 and 2021 identified 47 cases of ORN. Medical, dental and radiotherapy records of these forty-seven patients were retrospectively reviewed...
April 17, 2024: Radiotherapy and Oncology
#8
JOURNAL ARTICLE
Carl H Coleman
In response to the increasing number of mentally ill people experiencing homelessness, some policy-makers have called for the expanded use of involuntary commitment, even for individuals who are not engaging in behaviors that are immediately life-threatening. Yet there is no evidence that involuntary commitment offers long-term benefits, and significant reasons to believe that expanding the practice will cause harm. In addition, these proposals ignore research showing that most people with mental illness have the capacity to make medical decisions for themselves...
March 2024: Hastings Center Report
#9
JOURNAL ARTICLE
Michele Massimo Gulizia, Fabio Maria Turazza, Pietro Ameri, Marco Alings, Ronan Collins, Leonardo De Luca, Marcello Di Nisio, Donata Lucci, Domenico Gabrielli, Stefan Janssens, Iris Parrini, Fausto J Pinto, Jose Luis Zamorano, Furio Colivicchi
BACKGROUND: Cancer is an important condition associated with the development of atrial fibrillation (AF). The objectives of the BLITZ-AF Cancer study were to collect real-life information on the clinical profile and use of antithrombotic drugs in patients with AF and cancer to improve clinical management, as well as the evaluation of the association between different antithrombotic treatments (or their absence) and the main clinical events. METHODS: European multinational, multicenter, prospective, non-interventional study conducted in patients with AF (electrocardiographically confirmed) and cancer occurring within 3 years...
May 2024: Giornale Italiano di Cardiologia
#10
JOURNAL ARTICLE
Gabriel Gonzalez, Michael Carr, Tomás M Kelleher, Emer O'Byrne, Weronika Banka, Brian Keogan, Charlene Bennett, Geraldine Franzoni, Patrice Keane, Cliona Kenna, Luke W Meredith, Nicola Fletcher, Jose Maria Urtasun-Elizari, Jonathan Dean, Ciaran Browne, Fiona Lyons, Brendan Crowley, Derval Igoe, Eve Robinson, Greg Martin, Jeff Connell, Cillian F De Gascun, Daniel Hare
BackgroundMpox, caused by monkeypox virus (MPXV), was considered a rare zoonotic disease before May 2022, when a global epidemic of cases in non-endemic countries led to the declaration of a Public Health Emergency of International Concern. Cases of mpox in Ireland, a country without previous mpox reports, could reflect extended local transmission or multiple epidemiological introductions.AimTo elucidate the origins and molecular characteristics of MPXV circulating in Ireland between May 2022 and October 2023...
April 2024: Euro Surveillance
#11
JOURNAL ARTICLE
Chryso Th Pallari, Souzana Achilleos, Annalisa Quattrocchi, John Gabel, Elena Critselis, Maria Athanasiadou, Mohammad Reza Rahmanian Haghighi, Stefania Papatheodorou, Tianyu Liu, Andreas Artemiou, Jose M Rodriguez-Llanes, Catherine M Bennett, Claudia Zimmermann, Eva Schernhammer, Natalia Bustos Sierra, Reindert Ekelson, Jackeline Lobato, Laylla Macedo, Laust Hvas Mortensen, Julia Critchley, Lucy Goldsmith, Gleb Denissov, Nolwenn Le Meur, Levan Kandelaki, Kostas Athanasakis, Binyamin Binyaminy, Tamar Maor, Fabrizio Stracci, Giuseppe Ambrosio, Kairat Davletov, Nataliya Glushkova, Cyndy Martial, Marie Chan Sun, Terje P Hagen, Mario Chong, Manuel Barron, Błażej Łyszczarz, Ivan Erzen, Pedro Arcos Gonzalez, Bo Burström, Nataliia Pidmurniak, Olesia Verstiuk, Qian Huang, Antonis Polemitis, Andreas Charalambous, Christiana A Demetriou
INTRODUCTION: To examine the impact of the COVID-19 pandemic on mortality, we estimated excess all-cause mortality in 24 countries for 2020 and 2021, overall and stratified by sex and age. METHODS: Total, age-specific and sex-specific weekly all-cause mortality was collected for 2015-2021 and excess mortality for 2020 and 2021 was calculated by comparing weekly 2020 and 2021 age-standardised mortality rates against expected mortality, estimated based on historical data (2015-2019), accounting for seasonality, and long-term and short-term trends...
April 18, 2024: BMJ Global Health
#12
JOURNAL ARTICLE
Jacqui Wise
No abstract text is available yet for this article.
April 18, 2024: BMJ: British Medical Journal
#13
JOURNAL ARTICLE
A Martinez, G Iglesias
The complementarity of offshore wind and solar resources can enhance the energy output of a hybrid farm and reduce its variability relative to a stand-alone, conventional offshore wind farm. In this work offshore wind and solar resources are characterised and mapped in a large study area covering the European Atlantic, the North and Baltic Seas, and the Canary Islands. The intra-annual and overall variabilities of wind power density and solar irradiance are investigated, and their complementarity is evaluated on the basis of their correlation...
April 16, 2024: Science of the Total Environment
#14
JOURNAL ARTICLE
Gavin David Brown, Caroline McMullan, Ann Largey, David Leon
Nurses' household preparedness is critical if they are to avoid role conflict and report for duty during an emergency. To date, the alignment between nurses' perceived and actual household preparedness remains under examined. Investigating one of these variables in isolation fails to consider that perceived and actual household preparedness must be high and aligned. If misaligned, vulnerabilities could surface during emergencies, like concerns about family safety, potentially impacting a nurse's commitment to duty during a crisis, or nurses may lack the actual preparedness to continue working long hours during an emergency...
2024: PloS One
#15
JOURNAL ARTICLE
Lieke Brouwer, Robert Cunney, Richard J Drew
Early recognition of bloodstream infection (BSI) in infants can be difficult, as symptoms may be non-specific, and culture can take up to 48 h. As a result, many infants receive unneeded antibiotic treatment while awaiting the culture results. In this study, we aimed to develop a model that can reliably identify infants who do not have positive blood cultures (and, by extension, BSI) based on the full blood count (FBC) and C-reactive protein (CRP) values. Several models (i.e. multivariable logistic regression, linear discriminant analysis, K nearest neighbors, support vector machine, random forest model and decision tree) were trained using FBC and CRP values of 2693 infants aged 7 to 60 days with suspected BSI between 2005 and 2022 in a tertiary paediatric hospital in Dublin, Ireland...
April 18, 2024: European Journal of Pediatrics
#16
JOURNAL ARTICLE
Dbt Robinson, R Zakeri, L R Brown, R W Laing, C Choh, A Askari, M Abouelazayem, A Bradley, A C Currie, M Elmasry, Rpt Evans, Tmh Gall, E Jerome, N B Raftery, M Samuel, Hvm Spiers, Bky Chan
INTRODUCTION: Surgical training programmes in the United Kingdom and Ireland (UK&I) are in a state of flux. This study aims to report the contemporary opinions of trainee and consultant surgeons on the current upper gastrointestinal (UGI) training model in the UK&I. METHODS: A questionnaire was developed and distributed via national UGI societies. Questions pertained to demographics, current training evaluation, perceived requirements and availability. RESULTS: A total of 241 responses were received with representation from all UK&I postgraduate training regions...
April 18, 2024: Annals of the Royal College of Surgeons of England
#17
JOURNAL ARTICLE
Salima Meghani, Fiona Timmins
BACKGROUND: Delirium is an acute and fluctuating disturbance of cognition and is a common occurrence in critically ill patients. It is a manifestation of an acute brain dysfunction often attributed to higher survival rates and a subsequently aging population. Intensive Care Unit (ICU) treatment and survival often contributes towards development of delirium, and lack of or inappropriate management can translate into the development of long-term psychological effects that last even after discharge...
April 18, 2024: Nursing in Critical Care
#18
JOURNAL ARTICLE
Shona J Pryde, Owen Williams, Margaret P O'Hare, Carolyn Murdock, Katy Pedlow
PURPOSE: Community neurorehabilitation enables people with progressive neurological conditions (PNCs) to manage their symptoms to live an active, fulfilling life; however, it is not accessible to all. This study explored the factors influencing access to community neurorehabilitation in Northern Ireland from the perspective of people with PNCs and their carers. METHODS: Eleven people living with a PNC and three carers took part in virtual focus groups. Data was thematically analysed using the framework method...
April 18, 2024: Disability and Rehabilitation
#19
REVIEW
John Tayu Lee, Ian Crettenden, My Tran, Daniel Miller, Mark Cormack, Megan Cahill, Jinhu Li, Tomoko Sugiura, Fan Xiang
BACKGROUND: Health workforce projection models are integral components of a robust healthcare system. This research aims to review recent advancements in methodology and approaches for health workforce projection models and proposes a set of good practice reporting guidelines. METHODS: We conducted a systematic review by searching medical and social science databases, including PubMed, EMBASE, Scopus, and EconLit, covering the period from 2010 to 2023. The inclusion criteria encompassed studies projecting the demand for and supply of the health workforce...
April 17, 2024: Human Resources for Health
#20
JOURNAL ARTICLE
Kathryn Fu, James Walmsley, Mohamed Abdelrahman, David S Y Chan
BACKGROUND: As waiting lists for elective surgery grow, there seems to be a disconnect between the public's expectations on the amount of time surgeons spend operating compared with reality. On average, a surgeon in the NHS spends one day a week performing elective surgery. We aimed to investigate the public's perception on the amount of time surgeons spend performing elective surgery and what they would desire. METHODS: Members of the public in the UK were approached randomly either on-line or in-person to complete an anonymised 6-question survey...
April 16, 2024: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
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