Dong-Kun Xie, Jin Yao, Peng-Hui Li, Yan-Wen Zhu, Jia-Nuo Chen, Xiu-Li Cao, Shi-Lin Cheng, Ya-Miao Chen, Yi-Fei Huang, Liang Wang, Zan-Han Wang, Rong Qiao, Jia-Mei Ge, Huan Yue, Li Wei, Zhong-Yuan Liu, Hua Han, Hong-Yan Qin, Jun-Long Zhao
INTRODUCTION: Macrophages are an important component of innate immunity and involved in the immune regulation of multiple diseases. The functional diversity and plasticity make macrophages to exhibit different polarization phenotypes after different stimuli. During tumor progression, the M2-like polarized tumor-associated macrophages (TAMs) promote tumor progression by assisting immune escape, facilitating tumor cell metastasis, and switching tumor angiogenesis. Our previous studies demonstrated that functional remodeling of TAMs through engineered-modifying or gene-editing provides the potential immunotherapy for tumor...
2024: Frontiers in Immunology