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https://www.readbyqxmd.com/read/29667005/the-bmp-2-mutant-l51p-a-bmp-receptor-ia-binding-deficient-inhibitor-of-noggin
#1
REVIEW
Hany Mohamed Khattab, Satoshi Kubota, Masaharu Takigawa, Takuo Kuboki, Walter Sebald
The antagonist-specific regulation in tissue engineering constitutes important attempts to achieve an improved and rapid bone regeneration by controlling the natural biological response of the natural body growth factors. L51P is molecularly engineered bone morphogentic protein-2 (BMP-2) variant with a substitution of the 51st leucine with a proline residue. L51P is deficient in BMP receptor binding, but maintains its structure and affinity for inhibitory proteins such as noggin, chordin, and gremlin. These modifications convert the BMP-2 variant L51P into a receptor-inactive inhibitor of BMP antagonists...
April 17, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29666989/effect-of-nanoheat-stimulation-mediated-by-magnetic-nanocomposite-hydrogel-on-the-osteogenic-differentiation-of-mesenchymal-stem-cells
#2
Zheng Cao, Dan Wang, Yongsan Li, Wensheng Xie, Xing Wang, Lei Tao, Yen Wei, Xiumei Wang, Lingyun Zhao
Hyperthermia has been considered as a promising healing treatment in bone regeneration. We designed a tissue engineering hydrogel based on magnetic nanoparticles to explore the characteristics of hyperthermia for osteogenic regeneration. This nanocomposite hydrogel was successfully fabricated by incorporating magnetic Fe3 O4 nanoparticles into chitosan/polyethylene glycol (PEG) hydrogel, which showed excellent biocompatibility and were able to easily achieve increasing temperatures under an alternative magnetic field (AMF)...
April 3, 2018: Science China. Life Sciences
https://www.readbyqxmd.com/read/29666653/mesenchymal-stem-cells-in-oriented-plga-acecm-composite-scaffolds-enhance-structure-specific-regeneration-of-hyaline-cartilage-in-a-rabbit-model
#3
Weimin Guo, Xifu Zheng, Weiguo Zhang, Mingxue Chen, Zhenyong Wang, Chunxiang Hao, Jingxiang Huang, Zhiguo Yuan, Yu Zhang, Mingjie Wang, Jiang Peng, Aiyuan Wang, Yu Wang, Xiang Sui, Wenjing Xu, Shuyun Liu, Shibi Lu, Quanyi Guo
Articular cartilage lacks a blood supply and nerves. Hence, articular cartilage regeneration remains a major challenge in orthopedics. Decellularized extracellular matrix- (ECM-) based strategies have recently received particular attention. The structure of native cartilage exhibits complex zonal heterogeneity. Specifically, the development of a tissue-engineered scaffold mimicking the aligned structure of native cartilage would be of great utility in terms of cartilage regeneration. Previously, we fabricated oriented PLGA/ACECM (natural, nanofibrous, articular cartilage ECM) composite scaffolds...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29665454/comparison-of-the-mechanobiological-performance-of-bone-tissue-scaffolds-based-on-different-unit-cell-geometries
#4
Óscar L Rodríguez-Montaño, Carlos Julio Cortés-Rodríguez, Antonio E Uva, Michele Fiorentino, Michele Gattullo, Giuseppe Monno, Antonio Boccaccio
Enhancing the performance of scaffolds for bone regeneration requires a multidisciplinary approach involving competences in the fields of Biology, Medicine and Engineering. A number of studies have been conducted to investigate the influence of scaffolds design parameters on their mechanical and biological response. The possibilities offered by the additive manufacturing techniques to fabricate sophisticated and very complex microgeometries that until few years ago were just a geometrical abstraction, led many researchers to design scaffolds made from different unit cell geometries...
April 11, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29665386/enzymatically-crosslinked-and-mechanically-tunable-silk-fibroin-pullulan-hydrogels-for-mesenchymal-stem-cells-delivery
#5
Tao Li, Xiongbo Song, Changmei Weng, Xin Wang, Jiangyi Wu, Li Sun, Xiaoyuan Gong, Wei-Nan Zeng, Liu Yang, Cheng Chen
Hydrogels with good biocompatibility, proper degradation rates, and tissue-matched elasticity are widely used in tissue engineering, regenerative medicine, and drug delivery. In this study, enzymatically crosslinked biocompatible hydrogels were successfully developed using silk fibroin (SF) and pullulan (PL) under physiological conditions in the presence of both horseradish peroxidase (HRP) and hydrogen peroxide (H2 O2 ). A series of properties of the hydrogels including gelation time, equilibrium swelling, enzyme degradation, morphology, rheological property, and compression modulus of SF/PL hydrogels were studied by varying the concentration of PL...
April 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29665002/three-dimensional-collagenous-niche-and-azacytidine-selectively-promote-time-dependent-cardiomyogenesis-from-human-bone-marrow-derived-msc-spheroids
#6
Jyotsna Joshi, Gautam Mahajan, Chandrasekhar R Kothapalli
Endogenous adult cardiac regenerative machinery is not capable of replacing the lost cells following myocardial infarction, often leading to permanent alterations in structure-function-mechanical properties. Regenerative therapies based on delivering autologous stem cells within an appropriate 3D milieu could meet such demand, by enabling homing and directed differentiation of the transplanted cells into lost specialized cell populations. Since type I collagen is the predominant cardiac tissue matrix protein, we here optimized the 3D niche which could promote time-dependent evolution of cardiomyogenesis from human bone marrow-derived mesenchymal stem cells (BM-MSC)...
April 17, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29664609/using-an-engineered-galvanic-redox-system-to-generate-positive-surface-potentials-that-promote-osteogenic-functions
#7
Yulong Zhang, Zhong Zheng, Mengliu Yu, Chinyun Hsu, Emily Berthiaume, Hsinchuan Pan, Xinli Zhang, Adam Z Stieg, Benjamin Wu, Huiming Wang, Kang Ting, Chia Soo
Successful osseointegration of orthopaedic and orthodontic implants is dependent on a competition between osteogenesis and bacterial contamination on the implant-tissue interface. Previously, by taking advantage of the highly interactive capabilities of silver nanoparticles (AgNPs), we effectively introduced an antimicrobial effect to metal implant materials using a AgNP/poly(DL-lactic-co-glycolic acid) (PLGA) coating. Although electrical forces have been shown to promote osteogenesis, creating practical materials and devices capable of harnessing these forces to induce bone regeneration remains challenging...
April 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29663925/the-investigation-of-zno-poly-vinylidene-fluoride-nanocomposites-with-improved-mechanical-piezoelectric-and-antimicrobial-properties-for-orthopedic-applications
#8
Yuan Li, Linlin Sun, Thomas J Webster
Studies have shown that piezoelectric materials can be used as bioactively charged surfaces to induce tissue regeneration (like bone reconstruction). β-phase poly(vinylidene fluoride) (PVDF) and zinc oxide (ZnO) are regarded as potential bone tissue engineering materials because of their piezoelectricity and biocompatibility. Additionally, ZnO nanoparticles (NPs) are ideal materials to reduce infection. In this study, PVDF scaffolds doped with ZnO NPs (ZnO/PVDF) were prepared by electrospinning increasing ZnO concentrations and the ratio of the β-phase PVDF resulting in an enhanced the modulus, elongation to failure and load stress...
March 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29663821/lithium-prevents-cell-apoptosis-through-autophagy-induction
#9
H Kazemi, A Noori-Zadeh, S Darabi, F Rajaei
OBJECTIVE: Bone marrow stromal stem cells (BMSCs) are widely used as an available source for cell therapy, tissue engineering, and cellular differentiation-based techniques. Therefore, it is necessary to apply a simple method through which BMSCs can be protected from cell apoptosis under tough conditions of cell differentiation. Lithium treatment is one of the simple methods in this regard. METHODS: The isolated BMSCs were divided into three groups: (a) control, (b) serum deprivation and (c) LiCl...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29663809/distributions-the-importance-of-the-chemist-s-molecular-view-for-biological-materials
#10
Rachel Leah Merzel, Bradford G Orr, Mark M Banaszak Holl
Characterization of materials with biological applications and assessment of physiological effects of therapeutic interventions are critical for translating research to the clinic and preventing adverse reactions. Analytical techniques typically used to characterize targeted nanomaterials and tissues rely on bulk measurement. Therefore, the resulting data represent an average structure of the sample, masking stochastic (randomly generated) distributions that are commonly present. In this Perspective, we examine almost 20 years of work our group has done in different fields to characterize and control distributions...
April 17, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29662652/guided-bone-regeneration-using-a-bone-tissue-engineering-complex-consisting-of-a-poly-dl-lactide-membrane-and-bone-mesenchymal-stem-cells
#11
Dahui Wang, Yifeng Lin, Lian Chen, Yueqiang Mo, Peng Huang, Ruixue Ma
Developmental dysplasia of the hip (DDH) is one of the most common diseases encountered in pediatric orthopedic departments. Current treatment strategies seek to improve acetabular coverage, the principal defect of acetabular dysplasia, but are not very successful. We developed a guided bone regeneration (GBR) strategy to improve acetabular coverage via bone tissue engineering (BTE). Poly- dl -lactide (PDLLA) membranes were seeded with bone marrow mesenchymal stem cells (BMSCs) to form a BTE complex, which was then implanted into the superior margin of the acetabulum in a rabbit DDH model...
March 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29661978/control-of-cell-behaviour-through-nanovibrational-stimulation-nanokicking
#12
REVIEW
Shaun N Robertson, Paul Campsie, Peter G Childs, Fiona Madsen, Hannah Donnelly, Fiona L Henriquez, William G Mackay, Manuel Salmerón-Sánchez, Monica P Tsimbouri, Craig Williams, Matthew J Dalby, Stuart Reid
Mechanical signals are ubiquitous in our everyday life and the process of converting these mechanical signals into a biological signalling response is known as mechanotransduction. Our understanding of mechanotransduction, and its contribution to vital cellular responses, is a rapidly expanding field of research involving complex processes that are still not clearly understood. The use of mechanical vibration as a stimulus of mechanotransduction, including variation of frequency and amplitude, allows an alternative method to control specific cell behaviour without chemical stimulation (e...
May 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29661307/effect-of-ph-and-precursor-salts-on-in-situ-formation-of-calcium-phosphate-nanoparticles-in-methylcellulose-hydrogel
#13
Min Hee Kim, Hanna Park, Won Ho Park
Thermo-reversible hydrogels have been widely studied in biomedical research fields, because of their potential performance in drug delivery and tissue engineering. In this study, a novel thermo-sensitive methylcellulose (MC) hydrogel based on calcium phosphate nanoparticles (CaP NPs) was prepared by in situ formation process in which precursor salts induced a salt-out effect in the MC solution. Based on the Hofmeister series, CaCl2 , Na2 HPO4 , and NaH2 PO4 precursor salts with a good salt-out effect were used as the precursor salts for CaP NPs...
July 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29661034/the-use-of-chitosan-pla-nano-fibers-by-emulsion-eletrospinning-for-periodontal-tissue-engineering
#14
Renze Shen, Weihong Xu, Yanxiang Xue, Luyuan Chen, Haicheng Ye, Enyi Zhong, Zhanchao Ye, Jie Gao, Yurong Yan
OBJECTIVE: In this study, nanofibrous scaffolds base on pure polylactic acid (PLA) and chitosan/PLA blends were fabricated by emulsion eletrospinning. By modulating their mechanical and biological properties, cell-compatible and biodegradable scaffolds were developed for periodontal bone regeneration. METHODS: Pure PLA and different weight ratios of chitosan nano-particle/PLA nano-fibers were fabricated by emulsion eletrospinning. Scanning electron microscope (SEM) was performed to observe the morphology of nano-fibers...
April 16, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29660790/development-of-a-tissue-engineered-artificial-ligament-reconstruction-of-injured-rabbit-medial-collateral-ligament-with-elastin-collagen-and-ligament-cell-composite-artificial-ligament
#15
Masaki Hirukawa, Shingo Katayama, Tatsuya Sato, Kota Inoue, Kosuke Niwa, Naoya Ito, Tetsuya Hattori, Takashi Hosoi, Hironori Unno, Yoshiaki Suzuki, Masahiro Hasegawa, Keiichi Miyamoto, Takashi Horiuchi
Ligament reconstruction using a tissue-engineered artificial ligament (TEAL) requires regeneration of the ligament-bone junction such that fixation devices such as screws and end buttons do not have to be used. The objective of this study was to develop a TEAL consisting of elastin-coated polydioxanone (PDS) sutures covered with elastin and collagen fibers preseeded with ligament cells. In a pilot study, a ring-type PDS suture with a 2.5 mm (width) bone insertion was constructed with/without elastin coating (Ela-coat and Non-coat) and implanted into two bone tunnels, diameter 2...
April 16, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29659011/immune-system-augmentation-via-humanization-using-stem-progenitor-cells-and-bioengineering-in-a-breast-cancer-model-study
#16
Abbas Shafiee, Jacqui A McGovern, Christoph A Lahr, Christoph Meinert, Davide Moi, Ferdinand Wagner, Marietta Landgraf, Elena De-Juan-Pardo, Roberta Mazzieri, Dietmar W Hutmacher
Despite significant advances, most current in vivo models fail to fully recapitulate the biological processes that occur in humans. Here we aimed to develop an advanced humanized model with features of an organ bone by providing different bone tissue cellular compartments including pre-osteoblasts, mesenchymal stem/stromal (MSCs), endothelial and hematopoietic cells in an engineered microenvironment. The bone compartment was generated by culturing the human MSCs, umbilical vein endothelial cells with gelatin methacryloyl hydrogels in the centre of a melt-electrospun polycaprolactone tubular scaffolds which were seeded with human pre-osteoblasts...
April 16, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29658563/preclinical-evaluation-of-a-novel-engineered-recombinant-human-anti-cd44v6-antibody-for-potential-use-in-radio-immunotherapy
#17
Anja C Mortensen, Diana Spiegelberg, Anna-Karin Haylock, Hans Lundqvist, Marika Nestor
CD44v6 is overexpressed in a variety of cancers, rendering it a promising target for radio-immunotherapy (RIT). In this study, we have characterized a novel engineered recombinant monoclonal anti-CD44v6 antibody, AbN44v6, and assessed its potential for use in RIT using either 177Lu or 131I as therapeutic radionuclides. In vitro affinity and specificity assays characterized the binding of the antibody labeled with 177Lu, 125I or 131I. The therapeutic effects of 177Lu-AbN44v6 and 131I-AbN44v6 were investigated using two in vitro 3D tumor models with different CD44v6 expression...
April 11, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29658516/optimization-of-differentiation-time-of-mesenchymal-stem-cell-to-tenocyte-under-a-cyclic-stretching-with-a-microgrooved-culture-membrane-and-selected-measurement-cells
#18
Yasuyuki Morita, Takahiro Yamashita, Toku Toku, Yang Ju
PURPOSE: There is a need for efficient stem cell-to-tenocyte differentiation techniques for tendon tissue engineering. More than 1 week is required for tenogenic differentiation with chemical stimuli, including co-culturing. Research has begun to examine the utility of mechanical stimuli, which reduces the differentiation time to several days. However, the precise length of time required to differentiate human bone marrow-derived mesenchymal stem cells (hBMSCs) into tenocytes has not been clarified...
2018: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/29656699/hybrid-polycaprolactone-polyethylene-oxide-scaffolds-with-tunable-fiber-surface-morphology-improved-hydrophilicity-and-biodegradability-for-bone-tissue-engineering-applications
#19
Remya K R, Sunitha Chandran, Susan Mani, Annie John, P Ramesh
In the present study, we attempt to modify Polycaprolactone (PCL) by blending it with a water soluble polymer Polyethyleneoxide (PEO) having two different molecular weights (Mv ~1,00,000 and 6,00,000) using electrospinning technique. The effect of PEO molecular weight and blend ratio on fiber morphology, porosity, surface wettability, static and dynamic mechanical properties of PCL was investigated. In vitro degradation studies in phosphate buffer saline (PBS) at 37°C demonstrated formation of pores on fiber surface especially in blend scaffolds with 50:50 ratios...
April 16, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29656542/evaluation-of-permeability-and-fluid-wicking-in-woven-fiber-bone-scaffolds
#20
Jordon Gilmore, Freda Yin, Karen J L Burg
Research characterizing transport of nutrients and waste in tissue engineering scaffolds has led to the study of scaffold properties that contribute to permeability and porosity of the scaffold. Both permeability and porosity contribute to the transport properties of the scaffold; however, permeability relates to the degree to which pores are interconnected within the scaffold. This work evaluated permeability for woven polymer fiber scaffolds by modulating the following scaffold parameters: material combination, weave configuration, and fiber geometry...
April 15, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
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