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https://www.readbyqxmd.com/read/28549217/surface-enhanced-raman-scattering-active-gold-nanoparticles-with-enzyme-mimicking-activities-for-measuring-glucose-and-lactate-in-living-tissues
#1
Yihui Hu, Hanjun Cheng, Xiaozhi Zhao, Jiangjiexing Wu, Faheem Muhammad, Shichao Lin, Jian He, Liqi Zhou, Chengping Zhang, Yu Deng, Peng Wang, Zhengyang Zhou, Shuming Nie, Hui Wei
Gold nanoparticles (AuNPs) with simultaneous plasmonic and biocatalytic properties provide a promising approach to developing versatile bioassays. However, the combination of AuNPs' intrinsic enzyme mimicking properties with their surface-enhanced Ra-man scattering (SERS) activities has yet to be explored. Here we designed a peroxidase mimicking nanozyme by in situ growing AuNPs into a highly porous and thermally stable metal-organic framework (MOF) called MIL-101. The obtained AuNPs@MIL-101 nanozymes acted as the peroxidase mimics to oxidize Raman inactive reporter leucomalachite green (LMG) into the active malachite green (MG) with hydrogen peroxide, and simultaneously as the SERS substrates to enhance the Raman signals of the as-produced MG...
May 26, 2017: ACS Nano
https://www.readbyqxmd.com/read/28547871/sequence-based-analysis-of-protein-degradation-rates-a-computational-study-of-protein-degradation
#2
Miguel Correa Marrero, Aalt D J van Dijk, Dick de Ridder
Protein turnover is a key aspect of cellular homeostasis and proteome dynamics. However, there is little consensus on which properties of a protein determine its lifetime in the cell. In this work, we exploit two reliable datasets of experimental protein degradation rates to learn models and uncover determinants of protein degradation, with particular focus on properties that can be derived from the sequence. Our work shows that simple sequence features suffice to obtain predictive models of which the output correlates reasonably well with the experimentally measured values...
May 25, 2017: Proteins
https://www.readbyqxmd.com/read/28546342/intrinsic-frequency-response-patterns-in-mechano-sensory-neurons-of-the-leech
#3
Linda Fischer, Frank Scherbarth, Boris Chagnaud, Felix Felmy
Animals employ mechano-sensory systems to detect and explore their environment. Mechano-sensation encompasses stimuli like constant pressure, surface movement or vibrations at various intensities that need to be segregated in the central nervous system. Besides different receptor structures sensory filtering via intrinsic response properties could provide a convenient way to solve this problem. In leech, three major mechano-sensory cell types can be distinguished according to their stimulus sensitivity into nociceptive, pressure and touch cells...
May 25, 2017: Biology Open
https://www.readbyqxmd.com/read/28545587/type-2-diabetes-and-obesity-induce-similar-transcriptional-reprogramming-in-human-myocytes
#4
Leif Väremo, Tora Ida Henriksen, Camilla Scheele, Christa Broholm, Maria Pedersen, Mathias Uhlén, Bente Klarlund Pedersen, Jens Nielsen
BACKGROUND: Skeletal muscle is one of the primary tissues involved in the development of type 2 diabetes (T2D). The close association between obesity and T2D makes it difficult to isolate specific effects attributed to the disease alone. Therefore, here we set out to identify and characterize intrinsic properties of myocytes, associated independently with T2D or obesity. METHODS: We generated and analyzed RNA-seq data from primary differentiated myotubes from 24 human subjects, using a factorial design (healthy/T2D and non-obese/obese), to determine the influence of each specific factor on genome-wide transcription...
May 25, 2017: Genome Medicine
https://www.readbyqxmd.com/read/28544830/assessment-of-contributors-of-aortopathy-and-subclinical-left-ventricular-dysfunction-in-normally-functioning-bicuspid-aortic-valves
#5
Kamil Tuluce, Selcen Yakar Tuluce, Ersin Cagri Simsek, Serdar Bayata, Cem Nazli
BACKGROUND: Left ventricular (LV) function and the dimensions of aortic valves from normally functioning bicuspid aortic valve (BAV) patients were compared with those of healthy control patients. A comparison between patients with antero-posterior BAV (BAV-AP) or right-left BAV (BAV-RL) was also performed, and the determinants of aortopathy and LV function were investigated. METHODS: Sixty-eight patients with aortic velocities <2 m/s and trivial or mild aortic regurgitation were included in the study...
January 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28544169/recent-progress-of-first-principles-calculations-in-ch3nh3pbi3-perovskite-solar-cells
#6
Sining Yun, Xiao Zhou, Jacky Even, Anders Hagfeldt
Hybrid halide perovskite solar cells (PSCs) exceeding 22% power conversion efficiencies (PCEs) have attracted considerable global attention due to the intrinsic nature of perovskite. Although we all know about that perovskite plays a significant role in the operation of PSCs, the fundamental theories associated with perovskite have not been resolved by the exponential increase in research effort. This raises questions about whether the first-principles calculations are sufficiently addressing the underlying issues in perovskite...
May 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28542243/covalent-dye-attachment-influences-the-dynamics-and-conformational-properties-of-flexible-peptides
#7
Manuel P Luitz, Anders Barth, Alvaro H Crevenna, Rainer Bomblies, Don C Lamb, Martin Zacharias
Fluorescence spectroscopy techniques like Förster resonance energy transfer (FRET) and fluorescence correlation spectroscopy (FCS) have become important tools for the in vitro and in vivo investigation of conformational dynamics in biomolecules. These methods rely on the distance-dependent quenching of the fluorescence signal of a donor fluorophore either by a fluorescent acceptor fluorophore (FRET) or a non-fluorescent quencher, as used in FCS with photoinduced electron transfer (PET). The attachment of fluorophores to the molecule of interest can potentially alter the molecular properties and may affect the relevant conformational states and dynamics especially of flexible biomolecules like intrinsically disordered proteins (IDP)...
2017: PloS One
https://www.readbyqxmd.com/read/28541892/automatic-detection-of-retinal-lesions-for-screening-of-diabetic-retinopathy
#8
Sudeshna Sil Kar, Santi Maity
OBJECTIVE: Diabetic Retinopathy (DR) is characterized by the progressive deterioration of retina with the appearance of different types of lesions that include microaneurysms, hemorrhages, exudates etc. Detection of these lesions plays significant role for early diagnosis of DR. METHODS: To this aim, this paper proposes a novel and automated lesion detection scheme which consists of the four main steps: vessel extraction and optic disc removal, pre-processing, candidate lesion detection and post-processing...
May 24, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28541694/metal-organic-frameworks-for-heterogeneous-basic-catalysis
#9
Li Zhu, Xiao-Qin Liu, Hai-Long Jiang, Lin-Bing Sun
Great attention has been given to metal-organic frameworks (MOFs)-derived solid bases because of their attractive structure and catalytic performance in various organic reactions. The extraordinary skeleton structure of MOFs provides many possibilities for incorporation of diverse basic functionalities, which is unachievable for conventional solid bases. The past decade has witnessed remarkable advances in this vibrant research area; however, MOFs for heterogeneous basic catalysis have never been reviewed until now...
May 25, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28541270/negative-poisson-s-ratio-in-1t-type-crystalline-two-dimensional-transition-metal-dichalcogenides
#10
Liping Yu, Qimin Yan, Adrienn Ruzsinszky
Materials with a negative Poisson's ratio, also known as auxetic materials, exhibit unusual and counterintuitive mechanical behaviour-becoming fatter in cross-section when stretched. Such behaviour is mostly attributed to some special re-entrant or hinged geometric structures regardless of the chemical composition and electronic structure of a material. Here, using first-principles calculations, we report a class of auxetic single-layer two-dimensional materials, namely, the 1T-type monolayer crystals of groups 6-7 transition-metal dichalcogenides, MX2 (M=Mo, W, Tc, Re; X=S, Se, Te)...
May 25, 2017: Nature Communications
https://www.readbyqxmd.com/read/28540583/circadian-rhythm-in-melatonin-release-as-a-mechanism-to-reinforce-the-temporal-organization-of-the-circadian-system-in-crayfish
#11
Leonor Mendoza-Vargas, Armida Báez-Saldaña, Ramón Alvarado, Beatriz Fuentes-Pardo, Edgar Flores-Soto, Héctor Solís-Chagoyán
Melatonin (MEL) is a conserved molecule with respect to its synthesis pathway and functions. In crayfish, MEL content in eyestalks (Ey) increases at night under the photoperiod, and this indoleamine synchronizes the circadian rhythm of electroretinogram amplitude, which is expressed by retinas and controlled by the cerebroid ganglion (CG). The aim of this study was to determine whether MEL content in eyestalks and CG or circulating MEL in hemolymph (He) follows a circadian rhythm under a free-running condition; in addition, it was tested whether MEL might directly influence the spontaneous electrical activity of the CG...
June 2017: Invertebrate Neuroscience: IN
https://www.readbyqxmd.com/read/28539926/gene-specific-substitution-profiles-describe-the-types-and-frequencies-of-amino-acid-changes-during-antibody-somatic-hypermutation
#12
Zizhang Sheng, Chaim A Schramm, Rui Kong, James C Mullikin, John R Mascola, Peter D Kwong, Lawrence Shapiro
Somatic hypermutation (SHM) plays a critical role in the maturation of antibodies, optimizing recognition initiated by recombination of V(D)J genes. Previous studies have shown that the propensity to mutate is modulated by the context of surrounding nucleotides and that SHM machinery generates biased substitutions. To investigate the intrinsic mutation frequency and substitution bias of SHMs at the amino acid level, we analyzed functional human antibody repertoires and developed mGSSP (method for gene-specific substitution profile), a method to construct amino acid substitution profiles from next-generation sequencing-determined B cell transcripts...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28539362/solution-structure-of-domain-1-1-of-the-%C3%AF-a-factor-from-bacillus-subtilis-is-preformed-for-binding-to-the-rna-polymerase-core
#13
Milan Zachrdla, Petr Padrta, Alžbeta Rabatinová, Hana Šanderová, Ivan Barvík, Libor Krásný, Lukáš Žídek
Bacterial RNA polymerase (RNAP) requires σ factors to recognize promoter sequences. Domain 1.1 of primary σ factors (σ1.1) prevents their binding to promoter DNA in the absence of RNAP, and when in complex with RNAP, it occupies RNAP's DNA-binding channel. Currently, two 3D structures of σ1.1 are available: from Escherichia coli in complex with RNAP and from Thermotoga maritima solved free in solution. However, these two structures significantly differ, and it is unclear whether this difference is due to an altered conformation upon RNAP binding or to differences in intrinsic properties between the proteins from these two distantly related species...
May 24, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28537967/nortriptyline-enhances-morphine-conditioned-place-preference-in-neuropathic-rats-role-of-the-central-noradrenergic-system
#14
Wenli Mi, Shuxing Wang, Zerong You, Grewo Lim, Michael F McCabe, Hyangin Kim, Lucy Chen, Jianren Mao
BACKGROUND: Combination drug therapy is commonly used to treat chronic pain conditions such as neuropathic pain, and antidepressant is often used together with opioid analgesics. While rewarding is an intrinsic property of opioid analgesics, it is unknown whether the use of an antidepressant would influence opioid reward, which may contribute to opioid addiction. In this study, we examined whether nortriptyline (a tricyclic antidepressant and a first-line medication for neuropathic pain) would enhance the morphine rewarding property in both naive and chronic constriction sciatic nerve injury (CCI) rats...
May 19, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28537722/a-novel-micro-mea-design-to-precisely-measure-the-in-situ-activity-of-orr-electrocatalysts-for-pemfc
#15
Zhi Long, Yankai Li, Guangrong Deng, Changpeng Liu, Junjie Ge, Shuhua Ma, Wei Xing
An in-situ micro-MEA technique, which could precisely measure the performance of ORR electrocatalyst using Nafion as electrolyte, was designed and compared with regular thin-film rotating-disk electrode (TFRDE) (0.1 M HClO4) and normal in-situ membrane electrode assembly (MEA) tests. Compared to the traditional TFRDE method, the micro-MEA technique makes the acquisition of catalysts' behavior at low potential values easily achieved without being limited by the solubility of O2 in water. At the same time, it successfully mimics the structure of regular MEAs and obtains similar results to a regular MEA, thus providing a new technique to simply measure the electrode activity without being bothered by complicated fabrication of regular MEA...
May 24, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28537626/highly-transparent-supercapacitors-based-on-zno-mno2-nanostructures
#16
M A Borysiewicz, M Ekielski, Z Ogorzałek, M Wzorek, J Kaczmarski, T Wojciechowski
The recent rapid development of transparent electronics, notably displays and control circuits, requires the development of highly transparent energy storage devices, such as supercapacitors. The devices reported to date utilize carbon-based electrodes for high performance, however at the cost of their low transparency around 50%, insufficient for real transparent devices. To overcome this obstacle, in this communication highly transparent supercapacitors were fabricated based on ZnO/MnO2 nanostructured electrodes...
May 24, 2017: Nanoscale
https://www.readbyqxmd.com/read/28537606/two-excellent-phase-matchable-infrared-nonlinear-optical-materials-based-on-3d-diamond-like-frameworks-rbgasn2se6-and-rbinsn2se6
#17
Hua Lin, Hong Chen, Yu-Jun Zheng, Ju-Song Yu, Xin-Tao Wu, Li-Ming Wu
Mid- and far-infrared (MFIR) nonlinear optical (NLO) crystals with excellent performances are critical to laser frequency-conversion technology. However, the current commercial MFIR NLO crystals, including AgGaS2 (AGS), AgGaSe2 and ZnGeP2, suffer from certain intrinsic drawbacks and cannot achieve a good balance between large second-harmonic generation (SHG) efficiency and high laser-induced damage thresholds (LIDTs). Herein, we report two new phase-matchable MFIR NLO chalcogenides, specifically RbXSn2Se6 (X = Ga, In), which were successfully synthesized by high-temperature solid-state reactions...
May 24, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28537285/towards-improved-magnetic-fluid-hyperthermia-major-loops-to-diminish-variations-in-local-heating
#18
Cristina Munoz-Menendez, David Serantes, Juan M Ruso, Daniel Baldomir
In the context of using magnetic nanoparticles for heat-mediated applications, the need of an accurate knowledge of the local (at the nanoparticle level) heat generation in addition to the usually studied global counterpart has been recently highlighted. Such a need requires accurate knowledge of the links among the intrinsic particle properties, system characteristics and experimental conditions. In this work we have investigated the role of the particles' anisotropy polydispersity in relation to the amplitude (Hmax) of the AC magnetic field using a Monte Carlo technique...
May 24, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28537193/isolated-potato-virus-a-coat-protein-possesses-unusual-properties-and-forms-different-short-virus-like-particles
#19
Alexander L Ksenofontov, Eugeny N Dobrov, Natalia V Fedorova, Marina V Serebryakova, Andrei N Prusov, Ludmila A Baratova, Viiu Paalme, Lilian Järvekülg, Eleonora V Shtykova
In our previous study, we have observed that the isolated coat proteins (CP) of the Potyvirus Potato Virus A (PVA) virions exhibit an intrinsic tendency of to self-associate into various multimeric forms containing some fractions of cross-β-structure. In this report, we studied the effect of solution conditions on the structure and dissociation of isolated PVA CP using a number of complementary physicochemical methods. Analysis of the structure of PVA CP in solution was performed by limited proteolysis with MALDI-TOF Mass Spectrometry analysis, transmission electron microscopy, intrinsic fluorescence spectroscopy and synchrotron small angle X-ray scattering (SAXS)...
May 24, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28536473/athyrium-multidentatum-doll-ching-extract-induce-apoptosis-via-mitochondrial-dysfunction-and-oxidative-stress-in-hepg2-cells
#20
Guoyuan Qi, Zhigang Liu, Rong Fan, Ziru Yin, Yashi Mi, Bo Ren, Xuebo Liu
Athyrium multidentatum (Doll.) Ching (AMC), a unique and nutritious potherb widely distributed in china, has been extensively used in traditional Chinese medicine. Previous studies indicated that AMC extract exhibited antioxidant and antitumor properties. However, the chemical composition of AMC and molecular mechanism of AMC toxicity to HepG2 cells have not yet been elucidated. Hence, this study aimed to investigate the chemical compositions and the underlying mechanisms of the antiproliferative and apoptotic effects of AMC on HepG2...
May 23, 2017: Scientific Reports
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