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https://www.readbyqxmd.com/read/28209517/inadvertent-hypothermia-and-mortality-in-critically-ill-adults-systematic-review-and-meta-analysis
#1
REVIEW
Panagiotis Kiekkas, Fotini Fligou, Michael Igoumenidis, Nikolaos Stefanopoulos, Evangelos Konstantinou, Vasilios Karamouzos, Diamanto Aretha
OBJECTIVE: Considering that inadvertent hypothermia (IH) is common in Intensive Care Unit (ICU) patients and can be followed by severe complications, this systematic review identified, appraised and synthesized the published literature about the association between IH and mortality in adults admitted to the ICU. DATA SOURCES: By using key terms, literature searches were conducted in Pubmed, CINAHL, Cochrane Library, Web of Science and EMBASE. REVIEW METHODS: According to PRISMA guidelines, articles published between 1980-2016 in English-language, peer-reviewed journals were considered...
February 13, 2017: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/28205037/the-mesenteric-defects-in-laparoscopic-roux-en-y-gastric-bypass-5-years-follow-up-of-non-closure-versus-closure-using-the-stapler-technique
#2
Ebrahim Aghajani, Bent J Nergaard, Bjorn G Leifson, Jan Hedenbro, Hjortur Gislason
BACKGROUND: Internal hernia (IH) is a common complication of laparoscopic Roux-en-Y gastric bypass (LRYGB). Little large-volume data exist on how to handle the mesenteric defects during LRYGB. This study evaluated long-term follow-up (5.5 years) of 2443 patients with primary closure of the mesenteric defects with a stapling device at LRYGB, in comparison with a non-closed group from the same centre. METHODS: All patients (N = 4013) undergoing LRYGB over a 10-year period (2005-2015) at a single institution were evaluated...
February 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28202162/trends-in-open-abdominal-surgery-in-the-united-states-observations-from-9-950-759-discharges-using-the-2009-2013-national-inpatient-sample-nis-datasets
#3
Martin J Carney, Jason M Weissler, Justin P Fox, Michael G Tecce, Jesse Y Hsu, John P Fischer
INTRODUCTION: Incisional hernia (IH) represents a complex and costly surgical complication. We aim to address trends in open surgery to better understand potential drivers of hernia risk. MATERIAL AND METHODS: Using the 2009-2013 NIS, a cross-sectional review of hospital discharges associated with an open abdominal surgery was performed. RESULTS: Between 2009 and 2013, there were nearly 10 million discharges associated with an open abdominal surgery...
January 12, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28201878/au20si12-a-hollow-catalan-pentakis-dodecahedron
#4
J J Guo, H Y Zhao, J Wang, L Y Ai, Y Liu
A stable hollow Au20Si12 cage with Ih symmetry has been predicted using first-principles density functional theory. The stability of the cage-like Au20Si12 structure is verified by vibrational frequency analysis and molecular dynamics simulations. A relatively large highest occupied molecular orbital-lowest unoccupied molecular orbital gap of 1.057 eV is found. Electronic structure analysis shows that clearly p-d hybridizations between Si atoms and Au atoms are of great importance for the stability of Au20Si12 cage...
February 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28195035/pre-s2-mutant-induced-mammalian-target-of-rapamycin-signal-pathways-as-potential-therapeutic-targets-for-hepatitis-b-virus-associated-hepatocellular-carcinoma
#5
Chiao-Fang Teng, Han-Chieh Wu, Woei-Cherng Shyu, Long-Bin Jeng, Ih-Jen Su
Chronic hepatitis B virus (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC). Pre-S2 mutant represents an HBV oncoprotein that is accumulated in the endoplasmic reticulum (ER) and manifests as type II ground glass hepatocytes (GGHs). Pre-S2 mutant can induce ER stress and initiate multiple ER stress-dependent or -independent cellular signal pathways, leading to growth advantage of type II GGH. Importantly, the mammalian target of rapamycin (mTOR) signal pathways are consistently activated throughout the liver tumorigenesis in pre-S2 mutant transgenic mice and in human HCC tissues, leading to hepatocyte proliferation, metabolic disorders, and HCC tumorigenesis...
February 14, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28194399/the-role-of-permissive-and-induced-hypotension-in-current-neuroanesthesia-practice
#6
Suren Soghomonyan, Nicoleta Stoicea, Gurneet S Sandhu, Jeffrey J Pasternak, Sergio D Bergese
BACKGROUND: Induced hypotension (IH) had been used for decades in neurosurgery to reduce the risk for intraoperative blood loss and decrease blood replacement. More recently, this method fell out of favor because of concerns for cerebral and other end-organ ischemia and worse treatment outcomes. Other contributing factors to the decline in its popularity include improvements in microsurgical technique, widespread use of endovascular procedures, and advances in blood conservation and transfusion protocols...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28191657/prospective-open-label-rater-blinded-and-self-controlled-pilot-study-of-the-treatment-of-proliferating-superficial-infantile-hemangiomas-with-0-5-topical-timolol-cream-versus-595-nm-pulsed-dye-laser
#7
Hanru Ying, Yun Zou, Wenxin Yu, Yajing Qiu, Gang Ma, Lei Chang, Yifei Gu, Dongze Lyu, Xiaoxi Lin
Topical timolol and 595-nm pulsed dye laser (PDL) are both widely used in the treatment of superficial infantile hemangiomas (IH). However, to date, there is no reliable study comparing the therapeutic outcomes between the two treatment options. We designed the present study to evaluate and compare the efficacy and safety of timolol cream and PDL in the treatment of superficial proliferating IH. Twenty-one patients with superficial IH were included in the study. Each lesion was divided into two regions; one part was treated with 0...
February 13, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28190620/propranolol-treatment-of-infantile-hemangioma-is-not-associated-with-psychological-problems-at-7%C3%A2-years-of-age
#8
Andre Vadimovich Moyakine, Saskia Spillekom-van Koulil, Catharina Joanna Maria van der Vleuten
BACKGROUND: Concern has been raised about the potential long-term effects of propranolol treatment for infantile hemangioma (IH). OBJECTIVES: We sought to assess psychologic (social, emotional, behavioral, and executive) functioning in children treated with propranolol for IH. METHODS: Twenty-seven patients with IH (6.1-7.6 years of age) treated with propranolol for ≥6 months during infancy, and without other developmental risk factors, were recruited...
February 9, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28178574/is-acne-a-sign-of-androgen-excess-disorder-or-not
#9
Gulsum Uysal, Yılmaz Sahin, Kursad Unluhizarci, Ayten Ferahbas, Semih Zeki Uludag, Ercan Aygen, Fahrettin Kelestimur
OBJECTIVE: Acne is not solely a cosmetic problem. The clinical importance of acne in the estimation of androgen excess disorders is controversial. Recently, the Amsterdam ESHRE/ASRM-sponsored third PCOS Consensus Workshop Group suggested that acne is not commonly associated with hyperandrogenemia and therefore should not be regarded as evidence of hyperandrogenemia. Our aim was to investigate whether acne is a sign of androgen excess disorder or not. STUDY DESIGN: This is a cross sectional study that was performed in a university hospital involving 207 women, aged between 18 and 45 years, suffering mainly from acne...
January 23, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28178126/free-and-total-p-cresol-sulfate-levels-and-infectious-hospitalizations-in-hemodialysis-patients-in-choice-and-hemo
#10
Tanushree Banerjee, Timothy W Meyer, Tariq Shafi, Thomas H Hostetter, Michal Melamed, Yunnuo Zhu, Neil R Powe
The uremic syndrome is attributed to progressive retention of compounds that, under normal conditions, are excreted by the healthy kidneys. p-cresol sulfate (PCS), a prototype protein-bound uremic retention solute, has been shown to exert toxic effects in vitro. Recent studies have identified relations between increased levels of PCS and indoxyl sulfate (IS) and adverse clinical outcomes in hemodialysis patients. We explored the relationship between free and total PCS and IS with infection-related hospitalizations (IH) and septicemia in 2 cohorts, Choices for Healthy Outcomes in Caring for end-stage renal disease (ESRD) Study (CHOICE) and Hemodialysis Study (HEMO)...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28177899/mtor-autophagy-pathway-in-the-hippocampus-of-rats-suffering-intermittent-hypoxia-preconditioning-and-global-cerebral-ischemia-reperfusion
#11
Ya-Ning Zhao, Xiang-Fei Guo, Jian-Min Li, Chang-Xiang Chen, Shu-Xing Li, Cheng-Jing Xu
We explored the role of mTOR/autophagy pathway in the aggravation of cerebral ischemia-reperfusion nerve injury caused by intermittent hypoxia. Eighty male wistar rats were divided into four groups by the random number method: sham operation group (SO group, n=20), cerebral ischemia-reperfusion group (I/R group, n=20), intermittent hypoxia and cerebral ischemia-reperfusion group (IH+I/R group, n=20), intermittent hypoxia and cerebral ischemia-reperfusion group plus mTOR inhibitor group (inhibitor group, n=20)...
February 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28168756/small-infantile-hemangioma-and-breast-hypoplasia
#12
C Velter, C Gronier, D Lipsker
Large and/or segmental infantile hemangiomas (IH) are sometimes associated with other localized and/or more widespread malformations such as those occurring in the PHACES (1). Breast hypoplasia occurring after IH has been barely reported (2). We report the case of a small IH of the breast, associated with a homolateral breast hypoplasia and we raise the question of a potential link between the 2 findings. This article is protected by copyright. All rights reserved.
February 6, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28168585/variation-of-flow-rate-and-angle-of-injected-venous-needle%C3%A2-on-influencing-intimal-hyperplasia-at-the-venous-anastomosis-of-the-hemodialysis-graft
#13
Linqiang Yang, Aijun Yin, Wanqian Liu
During hemodialysis, arteriovenous (AV) grafts tends to result in intimal hyperplasia (IH) at the venous anastomosis which leads to graft failure. It is well documented that hemodynamic factors have been implicated in IH, as well as pathogenesis of graft stenosis. In this paper, we investigate the flow rate and angle of injection of a venous needle on damaging the hemodialysis graft. Such damage is mainly caused by hemodynamics rather than the actual physical puncture of the needle. By computational fluid dynamic analysis of flow through the AV grafts, we demonstrate that slower flow rate of the needle preserve a larger region of low wall shear stress (WSS)...
February 6, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28165488/restenosis-inhibition-and-re-differentiation-of-tgf%C3%AE-smad3-activated-smooth-muscle-cells-by-resveratrol
#14
Yichen Zhu, Toshio Takayama, Bowen Wang, Alycia Kent, Mengxue Zhang, Bernard Y K Binder, Go Urabe, Yatao Shi, Daniel DiRenzo, Shakti A Goel, Yifan Zhou, Christopher Little, Drew A Roenneburg, Xu Dong Shi, Lingjun Li, William L Murphy, K Craig Kent, Jianjuan Ke, Lian-Wang Guo
To date, there is no periadventitial drug delivery method available in the clinic to prevent restenotic failure of open vascular reconstructions. Resveratrol is a promising anti-restenotic natural drug but subject to low bioavailability when systemically administered. In order to reconcile these two prominent issues, we tested effects of periadventitial delivery of resveratrol on all three major pro-restenotic pathologies including intimal hyperplasia (IH), endothelium impairment, and vessel shrinkage. In a rat carotid injury model, periadventitial delivery of resveratrol either via Pluronic gel (2-week), or polymer sheath (3-month), effectively reduced IH without causing endothelium impairment and vessel shrinkage...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28160111/anatomical-retzius-space-preservation-is-associated-with-lower-incidence-of-postoperative-inguinal-hernia-development-after-robot-assisted-radical-prostatectomy
#15
K D Chang, A Abdel Raheem, G D R Santok, L H C Kim, T G H Lum, S H Lee, W S Ham, Y D Choi, K H Rha
BACKGROUND: Postoperative inguinal hernia (IH) is a non-negligible sequelae with a wide array of rates after robot-assisted laparoscopic radical prostatectomy (RALP). Our aim was to evaluate the incidence and risk factors of postoperative IH development in men undergoing RALP. METHODS: A retrospective analysis of 839 patients "541 of conventional-RALP (C-RALP), and 298 of Retzius sparing-RALP (RS-RALP)" received treatment of prostate cancer between 2005 and 2016 and met with our inclusion criteria was performed...
February 3, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28155101/intermittent-hypoxia-revisited-a-promising-non-pharmaceutical-strategy-to-reduce-cardio-metabolic-risk-factors
#16
Guillaume Costalat, Frederic Lemaitre, Barbara Tobin, Gillian Renshaw
PURPOSE: The study aims to investigate the effects of moderate intermittent hypoxia (IH) on key cardio-metabolic risk factors in overweight and obese subjects. METHODS: Six subjects were exposed to 10 sessions of moderate IH over 2 weeks (based on [Formula: see text]; ~70 min per session). Measures were made of blood glucose (GLU) and lactate (La(-)); high (HDLc) and low-density lipoproteins (LDLc); triglycerides (TRG), systolic (SBP), and diastolic blood pressure (DBP); and cardiac autonomic indices [root mean square of successive R-R interval differences (RMSSD) and short-term fractal scaling exponent (DFAα1)]...
February 2, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28153167/intermittent-hypoxia-causes-mandibular-growth-retardation-and-macroglossia-in-growing-rats
#17
Jun Hosomichi, Yo-Ichiro Kuma, Shuji Oishi, Hisashi Nagai, Hideyuki Maeda, Risa Usumi-Fujita, Yasuhiro Shimizu, Sawa Kaneko, Chisa Shitano, Jun-Ichi Suzuki, Ken-Ichi Yoshida, Takashi Ono
INTRODUCTION: In this study, we aimed to examine the role of intermittent hypoxia (IH) in dentofacial morphologic changes in growing rats. METHODS: Seven-week-old male rats were exposed to IH at 20 cycles per hour (nadir of 4% oxygen to peak of 21% oxygen) for 8 hours per day for 6 weeks. Control rats were exposed to normoxia (N). Maxillofacial growth was compared between the 2 groups by linear measurements on cephalometric radiographs. To examine the dental arch morphology, study models and microcomputed tomography images of the jaws were taken...
February 2017: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/28152134/the-tissue-expander-effect-in-early-surgical-management-of-select-focal-infantile-hemangiomas
#18
Tara E Brennan, Milton Waner, Teresa M O
Importance: The current standard of treatment for infantile hemangiomas (IHs) involves initial observation for regression throughout infancy and childhood, with or without medical management with β-blocker medications. Approximately 50% of the lesions respond almost completely to this regimen. However, the remaining 50% of the lesions, especially established focal IHs of the lip, nose, eyelids, forehead, cheek, and scalp, do not regress completely with this regimen or do so leaving a deformity; among these lesions, early surgical management may result in a superior aesthetic and functional outcome...
February 2, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28149510/breed-and-adaptive-response-modulate-bovine-peripheral-blood-cells-transcriptome
#19
Nataliya Pošćić, Tommaso Montanari, Mariasilvia D'Andrea, Danilo Licastro, Fabio Pilla, Paolo Ajmone-Marsan, Andrea Minuti, Sandy Sgorlon
BACKGROUND: Adaptive response includes a variety of physiological modifications to face changes in external or internal conditions and adapt to a new situation. The acute phase proteins (APPs) are reactants synthesized against environmental stimuli like stress, infection, inflammation. METHODS: To delineate the differences in molecular constituents of adaptive response to the environment we performed the whole-blood transcriptome analysis in Italian Holstein (IH) and Italian Simmental (IS) breeds...
2017: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/28145046/adamantylidene-addition-to-m3n-ih-c80-m-sc-lu-and-sc3n-d5h-c80-synthesis-and-crystallographic-characterization-of-the-5-6-open-and-6-6-open-adducts
#20
Michio Yamada, Tsuneyuki Abe, Chiharu Saito, Toshiki Yamazaki, Satoru Sato, Naomi Mizorogi, Zdenek Slanina, Filip Uhlik, Mitsuaki Suzuki, Yutaka Maeda, Yongfu Lian, Xing Lu, Marilyn M Olmstead, Alan L Balch, Shigeru Nagase, Takeshi Akasaka
Adamantylidene (Ad) additions to M3N@Ih-C80 (M = Sc, Lu) and Sc3N@D5h-C80 were conducted comprehensively by photochemical reactions with 2-adamantane-2,3'-[3H]-diazirine (1). In M3N@Ih-C80, the addition caused the rupture of the [6,6]- or [5,6]-bonds of the Ih-C80 cage, forming [6,6]-open fulleroids as a major isomer and [5,6]-open fulleroids as a minor isomer. In Sc3N@D5h-C80, the addition also proceeded regioselectively to yield three major isomers of Ad mono-adducts, despite the fact that nine types of C-C bonds exist in the D5h-C80 cage...
February 1, 2017: Chemistry: a European Journal
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