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https://www.readbyqxmd.com/read/28329512/propranolol-for-infantile-hemangiomas-in-developing-countries
#1
Josette McMichael, Leslie P Lawley
BACKGROUND: Propranolol is the treatment of choicefor complicated infantile hemangiomas (IH). However,in some locations, propranolol has not yet becomestandard of care. To our knowledge, until 2014,propranolol had not been used in Afghanistan totreat IH. OBJECTIVES: To raise further awareness thatpropranolol is the treatment of choice for complicatedIH, suggest a propranolol induction, maintenance,and taper protocol, show an example of therapeuticsuccess in a resource-limited country, and discusspotential challenges...
March 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329220/prolonged-exposures-to-intermittent-hypoxia-promote-visceral-white-adipose-tissue-inflammation-in-a-murine-model-of-severe-sleep-apnea-effect-of-normoxic-recovery
#2
Alex Gileles-Hillel, Isaac Almendros, Abdelnaby Khalyfa, Recep Nigdelioglu, Zhuanhong Qiao, Robert B Hamanaka, Gökhan M Mutlu, Mahzad Akbarpour, David Gozal
Study Objectives: Increased visceral white adipose tissue (vWAT) mass results in infiltration of inflammatory macrophages that drive inflammation and insulin resistance. Patients with obstructive sleep apnea (OSA) suffer from increased prevalence of obesity, insulin resistance and metabolic syndrome. Murine models of intermittent hypoxia (IH) mimicking moderate-severe OSA manifest insulin resistance following short-term IH. We examined in mice the effect of long-term IH on the inflammatory cellular changes within vWAT, and the potential effect of normoxic recovery (IH-R)...
December 22, 2016: Sleep
https://www.readbyqxmd.com/read/28327113/low-cell-number-single-tube-amplification-sta-of-total-rna-revealed-transcriptome-changes-from-pluripotency-to-endothelium
#3
Yi-Hsuan Lee, Ya-Wen Hsueh, Yao-Hung Peng, Kung-Chao Chang, Kuen-Jer Tsai, H Sunny Sun, Ih-Jen Su, Po-Min Chiang
BACKGROUND: In addition to messenger RNA (mRNA), noncoding RNAs (ncRNAs) are essential components in cellular machineries for translation and splicing. Besides their housekeeping functions, ncRNAs are involved in cell type-specific regulation of translation, mRNA stability, genome structure, and accessibility. To have a comprehensive understanding of the identities and functions of different cell types, a method to comprehensively quantify both mRNA and ncRNA in a sensitive manner is highly desirable...
March 21, 2017: BMC Biology
https://www.readbyqxmd.com/read/28302122/incidence-and-risk-factors-of-inguinal-hernia-after-robot-assisted-radical-prostatectomy
#4
Yuta Yamada, Tetsuya Fujimura, Hiroshi Fukuhara, Toru Sugihara, Kotaro Takemura, Shigenori Kakutani, Motofumi Suzuki, Tohru Nakagawa, Haruki Kume, Yasuhiko Igawa, Yukio Homma
BACKGROUND: Robot-assisted radical prostatectomy (RARP) has now become a gold standard approach in radical prostatectomy. The aim of this study was to investigate incidence and risk factors of inguinal hernia (IH) after RARP. METHODS: This study included 307 consecutive men who underwent RARP for the treatment of prostate cancer from January 2011 to August 2015. The incidence of IH after RARP was investigated. Clinical and pathological factors were also investigated to assess relationship with development of postoperative IH...
March 16, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28301759/ice-surfaces
#5
Mary Jane Shultz
Ice is a fundamental solid with important environmental, biological, geological, and extraterrestrial impact. The stable form of ice at atmospheric pressure is hexagonal ice, Ih Despite its prevalence, Ih remains an enigmatic solid, in part due to challenges in preparing samples for fundamental studies. Surfaces of ice present even greater challenges. Recently developed methods for preparation of large single-crystal samples make it possible to reproducibly prepare any chosen face to address numerous fundamental questions...
March 15, 2017: Annual Review of Physical Chemistry
https://www.readbyqxmd.com/read/28300223/role-of-cyclooxygenase-2-on-intermittent-hypoxia-induced-lung-tumor-malignancy-in-a-mouse-model-of-sleep-apnea
#6
Noelia Campillo, Marta Torres, Antoni Vilaseca, Paula Naomi Nonaka, David Gozal, Jordi Roca-Ferrer, César Picado, Josep Maria Montserrat, Ramon Farré, Daniel Navajas, Isaac Almendros
An adverse role for obstructive sleep apnea (OSA) in cancer epidemiology and outcomes has recently emerged from clinical and animal studies. In animals, intermittent hypoxia (IH) mimicking OSA promotes tumor malignancy both directly and via host immune alterations. We hypothesized that IH could potentiate cancer aggressiveness through activation of the cyclooxygenase-2 (COX-2) pathway and the concomitant increases in prostaglandin E2 (PGE2). The contribution of the COX-2 in IH-induced enhanced tumor malignancy was assessed using celecoxib as a COX-2 specific inhibitor in a murine model of OSA bearing Lewis lung carcinoma (LLC1) tumors...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28286469/the-ih-channel-gene-promotes-synaptic-transmission-and-coordinated-movement-in-drosophila-melanogaster
#7
Andrew P Hegle, C Andrew Frank, Anthony Berndt, Markus Klose, Douglas W Allan, Eric A Accili
Hyperpolarization-activated cyclic nucleotide-gated "HCN" channels, which underlie the hyperpolarization-activated current (Ih), have been proposed to play diverse roles in neurons. The presynaptic HCN channel is thought to both promote and inhibit neurotransmitter release from synapses, depending upon its interactions with other presynaptic ion channels. In larvae of Drosophila melanogaster, inhibition of the presynaptic HCN channel by the drug ZD7288 reduces the enhancement of neurotransmitter release at motor terminals by serotonin but this drug has no effect on basal neurotransmitter release, implying that the channel does not contribute to firing under basal conditions...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28284842/ageing-and-chronic-intermittent-hypoxia-mimicking-sleep-apnea-do-not-modify-local-brain-tissue-stiffness-in-healthy-mice
#8
Ignasi Jorba, Maria José Menal, Marta Torres, David Gozal, Gerard Piñol-Ripoll, Anna Colell, Josep M Montserrat, Daniel Navajas, Ramon Farré, Isaac Almendros
Recent evidence suggests that obstructive sleep apnea (OSA) may increase the risk of Alzheimer´s disease (AD), with the latter promoting alterations in brain tissue stiffness, a feature of ageing. Here, we assessed the effects of age and intermittent hypoxia (IH) on brain tissue stiffness in a mouse model of OSA. Two-month-old and 18-month-old mice (N=10 each) were subjected to IH (20% O2 40s - 6% O2 20s) for 8 weeks (6h/day). Corresponding control groups for each age were kept under normoxic conditions in room air (RA)...
March 6, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28284823/activation-of-the-nmda-receptor-neuronal-nitric-oxide-synthase-pathway-within-the-ventral-bed-nucleus-of-the-stria-terminalis-mediates-the-negative-affective-component-of-pain
#9
Satoshi Deyama, Yaya Sugano, Sakura Mori, Taiju Amano, Mitsuhiro Yoshioka, Katsuyuki Kaneda, Masabumi Minami
Pain consists of sensory and affective components. Although the neuronal mechanisms underlying the sensory component of pain have been studied extensively, those underlying its affective component are only beginning to be elucidated. Previously, we showed the pivotal role of the ventral part of the bed nucleus of the stria terminalis (vBNST) in the negative affective component of pain. Here, we examined the role of glutamate-nitric oxide (NO) signaling in the affective component of pain in rats using a conditioned place aversion (CPA) test...
March 9, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28283083/a-novel-model-to-assess-lamellar-signaling-relevant-to-preferential-weight-bearing-in-the-horse
#10
A K Gardner, A W van Eps, M R Watts, T A Burns, J K Belknap
Supporting limb laminitis (SLL) is a devastating sequela to severe unilateral lameness in equine patients. The manifestation of SLL, which usually only affects one limb, is unpredictable and the etiology is unknown. A novel, non-painful preferential weight bearing model designed to mimic the effects of severe unilateral forelimb lameness was developed to assess lamellar signaling events in the supporting limb (SL). A custom v-shaped insert was attached to the shoe of one forelimb to prevent normal weight bearing and redistribute weight onto the SL...
March 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28281035/acoustic-context-alters-vowel-categorization-in-perception-of-noise-vocoded-speech
#11
Christian E Stilp
Normal-hearing listeners' speech perception is widely influenced by spectral contrast effects (SCEs), where perception of a given sound is biased away from stable spectral properties of preceding sounds. Despite this influence, it is not clear how these contrast effects affect speech perception for cochlear implant (CI) users whose spectral resolution is notoriously poor. This knowledge is important for understanding how CIs might better encode key spectral properties of the listening environment. Here, SCEs were measured in normal-hearing listeners using noise-vocoded speech to simulate poor spectral resolution...
March 9, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28280694/effectiveness-and-versatility-of-biological-prosthesis-in-transplanted-patients
#12
Giovanni Vennarecci, Gianluca Mascianà, Edoardo De Werra, Giovanni Battista Levi Sandri, Daniele Ferraro, Mirco Burocchi, Giovanni Tortorelli, Nicola Guglielmo, Giuseppe Maria Ettorre
AIM: To emphasize the effectiveness and versatility of prosthesis, and good tolerance by patients with incisional hernia (IH). METHODS: From December 2001 to February 2016, 270 liver transplantations were performed at San Camillo Hospital. IH occurred in 78 patients (28.8%). IH usually appeared early within the first year post-orthotopic liver transplantation. In the first era, fascial defect was repaired by primary closure for defects smaller than 2.5 cm or with synthetic mesh for greater defects...
February 24, 2017: World Journal of Transplantation
https://www.readbyqxmd.com/read/28279700/molecular-and-immunohistochemical-expression-of-apoptotic-proteins-bax-bcl-2-and-caspase-3-in-infantile-hemangioma-tissues-as-an-effect-of-propranolol-treatment
#13
Aneta Wnęk, Ewa Andrzejewska, Józef Kobos, Katarzyna Taran, Przemysław Przewratil
BACKGROUND: Infantile hemangiomas (IHs) are the most common benign tumors of childhood. They are characterized by a unique clinical course with two phases, proliferation and involution, which are followed by regression. The therapy of infantile hemangiomas was revolutionized in 2008 by the introduction of propranolol, however, the mechanism of its influence on hemangiomas remains unclear. METHODS: The study included 71 patients with IHs, 27 of whom were treated with propranolol while the remaining 44 were used as a comparative group...
March 6, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28275803/-chinese-expert-consensus-on-the-use-of-topical-timolol-maleate-treatment-of-infantile-hemangiomas
#14
Jia-Wei Zheng, Xu-Kai Wang, Cheng-Hong Jiang, Zhong-Ping Qin, Xin-Dong Fan, Yao-Wu Yang, Ran Huo, Shao-Hua Liu, Ji-Hong Zhao, Xiao-Yong Wang, De-Kai Zhou, Shao-Rong Lei
Non-selective β-blocker propranolol has been proved by FDA as the first-line agent for infantile hemangioma (IH) with dramatic response. To reduce the side effects caused by systemic administration of propranolol, timolol maleate treatment has been increasingly used as an alternative to systemic β-blockers and watchful waiting for many IH patients in recent years. However, the appropriate indications, drug dosage, dosing regimen, time for initiation, optimal duration, monitoring for side effects still remains controversial...
December 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/28271713/evidence-of-oxygen-activation-in-the-reaction-between-an-n-heterocyclic-carbene-and-m3n-ih-7-c80-an-unexpected-method-of-steric-hindrance-release
#15
Muqing Chen, Wangqiang Shen, Ping Peng, Lipiao Bao, Shasha Zhao, Yunpeng Xie, Peng Jin, Hongyun Fang, Fang-Fang Li, Xing Lu
We herein demonstrate for the first time the unexpected oxygen-involving reaction between M3N@Ih(7)-C80 (M = Sc, Lu) and 1,3-bis(diisopropylphenyl)imidazol-2-ylene (1). By introducing a tiny amount of oxygen into the reaction, unprecedented products (2a for Sc3N@C80 and 3a for Lu3N@C80) with the normal carbene center C2 singly bonded to a triple hexagonal junction (THJ) cage carbon together with an oxygen atom bridging the same THJ carbon atom and a neighboring carbon atom forming an epoxy structure are obtained...
March 13, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28267689/an-educational-intervention-decreases-opioid-prescribing-after-general-surgical-operations
#16
Maureen V Hill, Ryland S Stucke, Michelle L McMahon, Julia L Beeman, Richard J Barth
OBJECTIVE: The aim of this study was to determine whether an educational intervention was sufficient to decrease opioid prescribing after general surgical operations. SUMMARY OF BACKGROUND DATA: We recently analyzed opioid prescription and use for 5 common outpatient operations at our institution: partial mastectomy (PM), PM with sentinel lymph node biopsy (PM SLNB), laparoscopic cholecystectomy (LC), laparoscopic inguinal hernia repair (LIH), and open inguinal hernia repair (IH)...
March 6, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28267198/serotonergic-transmission-at-merkel-discs-modulation-by-exogenously-applied-chemical-messengers-and-involvement-of-ih-currents
#17
Weipang Chang, Hirosato Kanda, Ryo Ikeda, Jennifer Ling, Jianguo G Gu
The Merkel disc is a main type of tactile end organ consisting of Merkel cells and Aβ-afferent endings that responds to tactile stimulation with slowly adapting type 1 (SA1) afferent impulses. Our recent study has shown that Merkel discs in whisker hair follicles are serotonergic synapses using endogenous serotonin to transmit tactile signals from Merkel cells to Aβ-afferent endings. In the present study, we hypothesize that tactile sensitivity of Merkel discs can be modulated by chemical messengers. We tested this hypothesis by determining whether and how SA1 responses of mouse whisker hair follicles may be affected by exogenously applied chemical messengers...
March 7, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28266177/tnf-%C3%AE-promotes-survival-and-migration-of-mscs-under-oxidative-stress-via-nf-%C3%AE%C2%BAb-pathway-to-attenuate-intimal-hyperplasia-in-vein-grafts
#18
Xiao Bai, Jie Xi, Yanwen Bi, Xin Zhao, Weidong Bing, Xiangbin Meng, Yimin Liu, Zhonglai Zhu, Guangmin Song
The oxidative stress caused by endothelial injury is involved in intimal hyperplasia (IH) in vein grafts. Mesenchymal stem cells (MSCs) can home to injured intima and promote endothelial repair. However, MSC apoptosis is increased accompanied by decreased functional activity under oxidative stress. Thus, we investigate whether tumour necrosis factor-α (TNF-α) can promote the survival and activity of MSCs under oxidative stress to reduce IH more effectively, and establish what role the NF-κB pathway plays in this...
March 7, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28258481/diarylheptanoids-suppress-proliferation-of-pancreatic-cancer-panc-1-cells-through-modulating-shh-gli-foxm1-pathway
#19
Guang-Zhi Dong, Ji Hye Jeong, Yu-Ih Lee, So Yoon Lee, Hui-Yuan Zhao, Raok Jeon, Hwa Jin Lee, Jae-Ha Ryu
Pancreatic cancer is one of the leading causes of cancer, and it has the lowest 5-year survival rates. It is necessary to develop more potent anti-pancreatic cancer drugs to overcome the fast metastasis and resistance to surgery, radiotherapy, chemotherapy, and combinations of these. We have identified several diarylheptanoids as anti-pancreatic cancer agents from Alpinia officinarum (lesser galangal) and Alnus japonica. These diarylheptanoids suppressed cell proliferation and induced the cell cycle arrest of pancreatic cancer cells (PANC-1)...
March 3, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28255159/high-intensity-aerobic-exercise-training-improves-chronic-intermittent-hypoxia-induced-insulin-resistance-without-basal-autophagy-modulation
#20
Marion Pauly, Allan Assense, Aurélie Rondon, Amandine Thomas, Hervé Dubouchaud, Damien Freyssenet, Henri Benoit, Josiane Castells, Patrice Flore
Chronic intermittent hypoxia (IH) associated with obstructive sleep apnea (OSA) is a major risk factor for cardiovascular and metabolic diseases (insulin resistance: IR). Autophagy is involved in the pathophysiology of IR and high intensity training (HIT) has recently emerged as a potential therapy. We aimed to confirm IH-induced IR in a tissue-dependent way and to explore the preventive effect of HIT on IR-induced by IH. Thirty Swiss 129 male mice were randomly assigned to Normoxia (N), Intermittent Hypoxia (IH: 21-5% FiO2, 30 s cycle, 8 h/day) or IH associated with high intensity training (IH HIT)...
March 3, 2017: Scientific Reports
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