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https://www.readbyqxmd.com/read/28647595/intermittent-hypoxia-caused-cognitive-dysfunction-relate-to-mirnas-dysregulation-in-hippocampus
#1
Huabin Gao, Zhaoli Han, Shan Huang, Ruojing Bai, Xintong Ge, Fanglian Chen, Ping Lei
Intermittent hypoxia (IH) is a characteristic pathophysiological change of obstructive sleep apnea (OSA), a commonly diagnosed chronic sleep disorder. With the process of OSA, patients will suffer from the nervous system damage and appear to multiple cognitive dysfunction. The mechanism that how IH causes cognitive impairment is still unknown. Both control and experimental rats were placed in conditions absence and presence of intermittent hypoxia (IH) for 8h a day for a week, two weeks and four weeks, and then followed by behavioral assessments with Morris Water Maze (MWM) test...
June 21, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28644490/potentiating-role-of-copper-on-spatial-memory-deficit-induced-by-beta-amyloid-and-evaluation-of-mitochondrial-function-markers-in-the-hippocampus-of-rats
#2
Ladan Behzadfar, Mohammad Abdollahi, Omid Sabzevari, Rohollah Hosseini, Ahmad Salimi, Parvaneh Naserzadeh, Mohammad Sharifzadeh, Jalal Pourahmad
Mounting evidence suggests that copper, a crucial element in normal brain function, plays an important role in the etiology of Alzheimer's disease, which is known as a neurodegenerative mitochondrial disorder. However, the precise mechanisms of its effects on cognitive and mitochondrial functions through the CNS have not been thoroughly recognized yet. In this study, we aimed to investigate the long-term (3-week) effects of copper sulfate (50, 100 and 200 mg kg(-1) day(-1)) exposure on learning and memory as well as on mitochondrial function in the hippocampus of rats in the presence and absence of beta amyloid (1 μg μl(-1) per side) intrahippocampally (IH)...
June 23, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28642292/frequency-and-magnitude-of-intermittent-hypoxia-modulate-endothelial-wound-healing-in-a-cell-culture-model-of-sleep-apnea
#3
Noelia Campillo, Bryan Falcones, Josep M Montserrat, David Gozal, Ana Obeso, Teresa Gallego-Martin, Daniel Navajas, Isaac Almendros, Ramon Farre
Intermittent hypoxia (IH) has been implicated in the cardiovascular consequences of obstructive sleep apnea (OSA). However, the lack of suitable experimental systems has precluded assessment as to whether IH is detrimental, protective or both for the endothelium. The aim of the work was to determine the effects of frequency and amplitude of IH oxygenation swings on aortic endothelial wound healing. Monolayers of human primary endothelial cells were wounded, and subjected to constant oxygenation (1%, 4%, 13% or 20% O2) or IH at different frequencies (0...
June 22, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28636340/three-dimensional-modeling-of-quasicrystal-structures-from-x-ray-diffraction-an-icosahedral-al-cu-fe-alloy
#4
Seung-Tae Hong
Quasicrystals (QCs) are well-ordered but aperiodic crystals with classically forbidden symmetries (such as 5-fold). High-dimensional (HD) crystallography is a standard method to locate atom positions explicitly. However, in practice, it is still challenging because of its complexity. Here, we report a new simple approach to three-dimensional (3D) atomic modeling derived from X-ray diffraction data, and apply it to the icosahedral QC Al0.63Cu0.25Fe0.12. Electron density maps were calculated directly from 3D diffraction data indexed with noninteger (fractional) numbers as measured, with proper phases; each of 2(5) = 32 possible phase assignments for the five strongest reflections was used for Fourier synthesis...
June 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28631087/molar-incisor-hypomineralization-proportion-and-severity-in-primary-public-school-children-in-graz-austria
#5
Barbara Buchgraber, Lumnije Kqiku, Kurt A Ebeleseder
OBJECTIVE: The aim of this study was to determine the proportion and severity of molar incisor hypomineralization (MIH) in primary school children in Graz (southeast of Austria). MATERIALS AND METHODS: In 1111 children aged 6 to 12 years (mean age 9.0 ± 1.2), a wet examination of all teeth was performed by three trained examiners using a dental chair, optimal illumination, a dental mirror, and a dental explorer. All teeth with MIH lesions were registered so that different definitions of MIH were applicable...
June 19, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28630334/correction-for-brumberg-et-al-single-crystal-ih-ice-surfaces-unveil-connection-between-macroscopic-and-molecular-structure
#6
(no author information available yet)
No abstract text is available yet for this article.
June 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28629534/heparin-derived-oligosaccharide-inhibits-vascular-intimal-hyperplasia-in-balloon-injured-carotid-artery
#7
Jie-Ru Liu, Jie Wu, Xin-Chao Yu, Xuan Qian, Rui Xiong, Hui-Fang Wang, Dan-Feng Yu, Fei-Fei Liu, Shu-Ying He
The aims of the present study were to determine the effects of heparin-derived oligosaccharides (HDOs) on vascular intimal hyperplasia (IH) in balloon-injured carotid artery and to elucidate the underlying mechanisms of action. An animal model was established by rubbing the endothelia within the common carotid artery (CCA) in male rabbits. The rabbits were fed a high-cholesterol diet. Arterial IH was determined by histopathological changes to the CCA. Serum lipids were detected using an automated biochemical analysis...
June 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28624560/intracranial-hypotension-following-traumatic-brain-injury-a-diagnostic-and-therapeutic-challenge
#8
Jacob Chen Ming Low, Anan Shtaya, Samantha Hettige
BACKGROUND: Intracranial hypotension (IH) is a recognised cause of coma, however, the diagnosis is often challenging, especially in patients with superimposed traumatic brain injury (TBI). CASE REPORT: We report a case of a 67-year-old patient who became comatose following evacuation of bilateral acute subdural haematomas with concurrent respiratory failure. Imaging and intraparenchymal intracranial pressure (ICP) monitoring confirmed secondary IH. She was managed with an epidural blood patch, and a 72 hours period in the trendelenberg position guided by ICP monitoring and clinical assessment...
June 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28624295/molecular-characterization-of-sarcocystis-spp-in-intestine-mucosal-scrapings-and-fecal-samples-of-pampas-fox-lycalopex-gymnocercus
#9
Nathalia Paula Scioscia, María Laura Gos, Guillermo María Denegri, Gastón Moré
Sarcocystis spp. are obligatory intracellular protozoan parasites which can infect humans and animals. Most of Sarcocystis species were identified based on the detection of muscle cysts in different intermediate hosts (IH). Regarding to natural infection in definitive host, there are few reports which have reached to determining species of Sarcocystis. The present work was aimed to studying the occurrence of Sarcocystis spp. (oocysts and sporocysts) in mucosal scrapings of small intestine and fecal samples of one the most abundant wild canids from South America, Lycalopex gymnocercus (Pampas fox), and to identify the Sarcocystis spp...
June 14, 2017: Parasitology International
https://www.readbyqxmd.com/read/28623871/simple-computing-of-the-viscosity-of-water-dioxane-mixtures-according-to-a-fluctuating-spc-e-ih-interstitial-model
#10
Anis Ghazouani, Jalel M'halla
In this contribution, we propose a new simple and fast computing approach to model liquid water and water-1,4 dioxane mixture, which is intermediate between molecular dynamics calculation and lattice fluid H-bonding theory in which water molecules are arranged according to a fluctuating hexagonal Ih network. It generalizes the interstitial mixture models of Samoilov and Pauling by increasing the number of spatial configurations into the space of phases due to the addition of rotations and vibrations of the molecules around their equilibrium positions...
June 17, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28621464/differences-in-excitability-properties-between-mg-ta-and-apb-motor-axons
#11
Cliff S Klein, Chen Ning Zhao, Hui Liu, Ping Zhou
INTRODUCTION: Excitability properties of motor nerves to different muscles are different, but the explanation is uncertain. We characterized motor axon excitability properties to the medial gastrocnemius (MG) in 27 adults, and made comparisons with the peroneal nerve to the tibialis anterior (TA) and median nerve to the abductor pollicis brevis (APB) in 10 subjects. METHODS: Recordings of multiple excitability properties were made using threshold tracking, stimulating the nerves at the wrist or knee...
June 16, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28611523/surgical-management-of-liver-diseases-invading-the-hepatocaval-confluence-based-on-ih-classification-the-surgical-guideline-in-our-center
#12
Wei Li, Jun Han, Zhao-Ping Wu, Hong Wu
AIM: to investigate the short-term outcomes and risk factors indicating postoperative death of patients with lesions adjacent to the hepatocaval confluence. METHODS: We retrospectively analyzed 54 consecutive patients who underwent hepatectomy combined with inferior vena cava (IVC) and/or hepatic vein reconstruction (HVR) from January 2012 to January 2016 at our liver surgery center. The patients were divided into 5 groups according to the range of IVC and hepatic vein involvement...
May 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28608294/internalized-homophobia-and-drug-use-in-a-national-cohort-of-gay-and-bisexual-men-examining-depression-sexual-anxiety-and-gay-community-attachment-as-mediating-factors
#13
Raymond L Moody, Tyrel J Starks, Christian Grov, Jeffrey T Parsons
The minority stress process of internalized homophobia (IH) has been associated with a range of adverse health outcomes among gay and bisexual men (GBM). However, evidence is mixed regarding the effect of IH on drug use, suggesting the potential role of multiple mediated pathways. Researchers have linked depression, sexual anxiety, and gay community attachment with IH. Depression, sexual anxiety, and gay community attachment have also been linked with drug use and drug-related problems suggesting potential mediating roles...
June 12, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28608115/phase-i-trial-of-antigen-targeted-autologous-dendritic-cell-based-vaccine-with-in-vivo-activation-of-inducible-cd40-for-advanced-prostate-cancer
#14
Guru Sonpavde, John D McMannis, Yu Bai, Mamatha R Seethammagari, Joan M C Bull, Victoria Hawkins, Theresa K Dancsak, Natasha Lapteva, Jonathan M Levitt, Annemarie Moseley, David M Spencer, Kevin M Slawin
This phase I trial reports the safety and activity of BPX101, a second-generation antigen-targeted autologous antigen presenting cell (APC) vaccine in men with metastatic castration-resistant prostate cancer (mCRPC). To manufacture BPX101, APCs collected in a single leukapheresis were transduced with adenoviral vector Ad5f35 encoding inducible human (ih)-CD40, followed by incubation with protein PA001, which contains the extracellular domain of human prostate-specific membrane antigen. The ih-CD40 represents a modified chimeric version of the dendritic cell (DC) co-stimulatory molecule, CD40, which responds to a bioinert membrane-permeable activating dimerizer drug, rimiducid (AP1903), permitting temporally controlled, lymphoid-localized, DC-specific activation...
June 12, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28601470/tissue-and-serum-mrna-profile-of-mmps-2-9-as-a-potential-novel-biomarker-for-the-most-individual-approach-in-infantile-hemangiomas-and-cancer-disease
#15
Katarzyna Taran, Aneta Wnęk, Józef Kobos, Ewa Andrzejewska, Przemysław Przewratil
Propranolol is a widely-known beta-blocker approved for treating infantile hemangiomas (IH). The mechanisms behind the spectacular IH involution after propranolol treatment remain unclear. Recently, there is strong evidence of overexpression of numerous angiogenic factors in IH tissues, and it is reported that propranolol influences their pathways. However, a number of MMPs studies is highly limited. Here, for the first time, we propose a comprehensive approach by analyzing the expression levels of metalloproteinases-2/9 (MMPs-2/9) and tissue metalloproteinase inhibitor-2 (TIMP-2) in vivo on both, molecular and immunohistochemical levels, and in both, IH tissues and in the serum of IH patients, and relates the obtained results to the tumor's biology and systemic propranolol treatment...
June 3, 2017: Immunobiology
https://www.readbyqxmd.com/read/28598269/cancer-mortality-in-yukon-1999-2013-elevated-mortality-rates-and-a-unique-cancer-profile
#16
Jonathan Simkin, Ryan Woods, Catherine Elliott
BACKGROUND: Although cancer is the leading cause of death in Canada, cancer in the North has been incompletely described. OBJECTIVE: To determine cancer mortality rates in the Yukon Territory, compare them with Canadian rates, and identify major causes of cancer mortality. DESIGN: The Yukon Vital Statistics Registry provided all cancer deaths for Yukon residents between 1999-2013. Age-standardised mortality rates (ASMRs) were calculated using direct standardisation and compared with Canadian rates...
2017: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/28596044/incidence-recurrence-and-risk-factors-of-hernias-following-stoma-reversal
#17
Brad S Oriel, Qi Chen, Kamal M F Itani
BACKGROUND: To determine the incidence and risk factors for stoma site (SSH) and incisional (IH) hernias following stoma reversal as well as their recurrence following repair. METHODS: A cohort of VA Surgical Quality Improvement Program patients undergoing stoma reversal from 2002 to 2014 were evaluated at a single institution. Variables were selected a priori and evaluated by univariate analyses. RESULTS: Of 114 stoma reversals, 63 utilized a midline approach...
June 3, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28594929/intermittent-hypoxia-increases-kidney-tumor-vascularization-in-a-murine-model-of-sleep-apnea
#18
Antoni Vilaseca, Noelia Campillo, Marta Torres, Mireia Musquera, David Gozal, Josep M Montserrat, Antonio Alcaraz, Karim A Touijer, Ramon Farré, Isaac Almendros
We investigate the effects of intermittent hypoxia (IH), a characteristic feature of obstructive sleep apnea (OSA), on renal cancer progression in an animal and cell model. An in vivo mouse model (Balb/c, n = 50) of kidney cancer was used to assess the effect of IH on tumor growth, metastatic capacity, angiogenesis and tumor immune response. An in vitro model tested the effect of IH on RENCA cells, macrophages and endothelial cells. Tumor growth, metastatic capacity, circulating vascular endothelial growth factor (VEGF) and content of endothelial cells, tumor associated macrophages and their phenotype were assessed in the tumor...
2017: PloS One
https://www.readbyqxmd.com/read/28594573/activation-of-integrated-stress-response-and-metabolic-dysfunction-in-a-murine-model-of-sleep-apnea
#19
Abdelnaby Khalyfa, Zhuanhong Qiao, Alex Gileles-Hillel, Ahamed A Khalyfa, Mahzad Akbarpour, Brian Popko, David Gozal
BACKGROUND: Intermittent hypoxia (IH) induces activation of the integrated stress response (ISR), but its role in IH-induced visceral white adipose tissue (vWAT) insulin resistance in unknown. CHOP is activated by chronic ISR, while GADD34 dephosphorylates the subunit of translation initiation factor 2 (eIF2α), leading to termination of ISR. We hypothesized that CHOP/Gadd34 null mice would not manifest evidence of insulin resistance following IH exposures. METHODS: 8-week-old CHOP/GADD34-/- (DM) and wild type (WT) littermates were randomly assigned to IH or RA exposures for 6 weeks...
June 8, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28592413/recruitment-of-endosomal-signaling-mediates-the-forskolin-modulation-of-guinea-pig-cardiac-neuron-excitability
#20
Jean C Hardwick, Todd A Clason, John D Tompkins, Beatrice M Girard, Caitlin N Baran, Laura A Merriam, Victor May, Rodney L Parsons
Forskolin, a selective activator of adenylyl cyclase (AC), commonly is used to establish actions of G protein coupled receptors (GPCRs) that are initiated primarily through activation of AC/cAMP signaling pathways. In the present study, forskolin was used to evaluate the potential role of AC/cAMP, which is a major signaling mechanism for the pituitary adenylate cyclase-activating polypeptide (PACAP)-selective PAC1 receptor, in the regulation of guinea pig cardiac neuronal excitability. Forskolin (5-10 µM) increases excitability in ~60 % of the cardiac neurons...
June 7, 2017: American Journal of Physiology. Cell Physiology
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