Panpan Wei, Kangli Tian, Haole Liu, Kexin Li, Naqash Alam, Daxin Cheng, Meng Li, Xue He, Jia Guo, Rong Wang, Weirong Wang, Liang Bai, Enqi Liu, Baohui Xu, Yankui Li, Sihai Zhao
Intimal hyperplasia (IH) is a common pathological feature of vascular proliferative diseases, such as atherosclerosis and restenosis after angioplasty. Urotensin II (UII) and its receptor (UTR) are widely expressed in cardiovascular tissues. However, it remains unclear whether the UII/UTR system is involved in IH. Right unilateral common carotid artery ligation was performed and maintained for 21 days to induce IH in UTR knockout (UTR-/- ) and wild-type (WT) mice. Histological analysis revealed that compared with WT mice, UTR-deficient mice exhibited a decreased neointimal area, angiostenosis and intima-media ratio...
April 15, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease