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https://www.readbyqxmd.com/read/27913427/intermittent-hypoxia-during-recovery-from-neonatal-hyperoxic-lung-injury-causes-long-term-impairment-of-alveolar-development-a-new-rat-model-of-bpd
#1
Anastasiya Mankouski, Crystal Kantores, Mathew J Wong, Julijana Ivanovska, Amish Jain, Eric J Benner, Stanley N Mason, A Keith Tanswell, Richard L Auten, Robert P Jankov
Bronchopulmonary dysplasia (BPD) is a chronic lung injury characterized by impaired alveologenesis that may persist into adulthood. Rat models of BPD using varying degrees of hyperoxia to produce injury either cause early mortality or spontaneously recover following removal of the inciting stimulus, thus limiting clinical relevance. We sought to refine an established rat model induced by exposure to 60% O2 from birth by following hyperoxia with intermittent hypoxia (IH). Rats exposed from birth to air or 60% O2 until day 14 were recovered in air with or without IH (FiO2 = 0...
December 2, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27911476/nd-yag-and-pulsed-dye-laser-therapy-in-infantile-hemangiomas-a-retrospective-analysis-of-271-treated-hemangiomas-in-149-children
#2
F Hartmann, A Lockmann, L-L Grönemeyer, H A Haenssle, M Zutt, H von Fintel, I Kühnle, M P Schön, K-M Thoms
BACKGROUND: Infantile hemangiomas (IH) are common benign tumors in infancy. Most IH resolve spontaneously, but some require treatment due to ulceration, functional impairment or cosmetic disfiguration. While systemic propranolol is effective in many cases, laser therapy may be a safe topical alternative. OBJECTIVE: To assess the efficacy of combined Nd:YAG/pulsed dye laser (PDL) or PDL alone for therapy of IH. PATIENTS AND METHODS: 271 IH in 149 infants were treated with combined Nd:YAG/PDL or PDL alone...
December 2, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27910891/elevated-cerebral-spinal-fluid-biomarkers-in-children-with-mucopolysaccharidosis-i-h
#3
Gerald V Raymond, Marzia Pasquali, Lynda E Polgreen, Patricia I Dickson, Weston P Miller, Paul J Orchard, Troy C Lund
Mucopolysaccharidosis (MPS) type-IH is a lysosomal storage disease that results from mutations in the IDUA gene causing the accumulation of glycosaminoglycans (GAGs). Historically, children with the severe phenotype, MPS-IH (Hurler syndrome) develop progressive neurodegeneration with death in the first decade due to cardio-pulmonary complications. New data suggest that inflammation may play a role in MPS pathophysiology. To date there is almost no information on the pathophysiologic changes within the cerebral spinal fluid (CSF) of these patients...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27910603/investigation-on-quench-initiation-and-propagation-characteristics-of-gdbco-coil-co-wound-with-a-stainless-steel-tape-as-turn-to-turn-metallic-insulation
#4
Y G Kim, J B Song, Y H Choi, D G Yang, S G Kim, H G Lee
This paper investigates the quench initiation and propagation characteristics of a metallic insulation (MI) coil by conducting thermal quench tests for a GdBCO single-pancake coil co-wound with a stainless steel tape as the turn-to-turn MI. The test results confirmed that the MI coil exhibited superior thermal and electrical stabilities compared to the conventional coils co-wound with organic insulation material because the operating current could flow along the radial direction due to the existence of a turn-to-turn contact when a local hot spot was generated...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27902407/genomic-characterization-of-two-new-enterovirus-types-ev-a114-and-ev-a121
#5
Jagadish M Deshpande, Deepa K Sharma, Vinay K Saxena, Sushmitha A Shetty, Tarique Husain Ih Qureshi, Uma P Nalavade
Enteroviruses cause a variety of illnesses of the gastrointestinal tract, central nervous system as well as cardiovascular system. Phylogenetic analysis of VP1 sequences has identified 106 different human enteroviruses classified into four enterovirus species within genus Enterovirus of the Picornaviridae family. It is likely that not all enterovirus types have been discovered. Between September 2013 and October 2014, stool samples of 6274 apparently healthy children up to 5 years of age residing in Gorakhpur district, Uttar Pradesh, India were screened for enteroviruses...
October 28, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27902263/terrimonas-rhizosphaerae-sp-nov-isolated-from-ginseng-rhizosphere-soil
#6
Song-Ih Han, Ye-Rim Lee, Ju-Ok Kim, Kyung-Sook Whang
The novel isolate belonging to the genus Terrimonas, designated CR94T, was isolated from rhizosphere soil of ginseng field in Geumsan in Korea. Cells of Strain CR94T were strictly aerobic, Gram staining negative, non-motile, non-filamentous single rods. Growth was observed at 10-37℃ (optimum 28℃) and at pH4.0-10.0 (optimum pH6.0). Phylogenetic analyses based on 16S rRNA gene sequences indicated that strain CR94T belonged to the genus Terrimonas, showing the highest sequence similarity to Terrimonas lutea DYT (97...
November 2, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27902258/marinobacter-halotolerans-sp-nov-a-halophilic-bacterium-isolated-from-crystallizing-pond-of-saltern
#7
Ju-Ok Kim, Hyo-Jin Lee, Song-Ih Han, Kyung-Sook Whang
A Gram-staining-negative, moderately halophilic, motile bacterium, designated strain CP12T, was isolated from crystallizing pond of saltern of the Yellow Sea in Korea. Cells of strain CP12T were observed non-spore-forming rods and produce whitish yellow-coloured colonies. Growth was observed at 10-37 °C (optimum 37 °C), at pH 6.0-9.0 (optimum 7.0), and in the presence of 0.5-20 % (w/v) NaCl (optimum 3 %). Phylogenetic analysis based on the 16S rRNA gene sequence revealed that strain CP12T was closely related to Marinobacter flavimaris SW-145T (98...
November 9, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27901270/adipose-tissue-inflammation-by-intermittent-hypoxia-mechanistic-link-between-obstructive-sleep-apnoea-and-metabolic-dysfunction
#8
Silke Ryan
Obstructive sleep apnoea (OSA) is a highly prevalent condition and recognized as a major public health burden conveying a significant risk of cardiometabolic diseases and mortality. Type 2 diabetes (T2D), insulin resistance (IR) and glucose tolerance are common in subjects with OSA and this association is at least in part independent of the effects of obesity. Continuous positive airway pressure (CPAP) is the treatment of choice for the majority of patients with OSA but the benefit of CPAP on glycaemic health is uncertain...
November 29, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27895509/effects-of-fentanyl-on-pain-and-motor-behaviors-following-a-collagenase-induced-intracerebral-hemorrhage-in-rats
#9
Laurence Saine, Pierre Hélie, Pascal Vachon
PURPOSE: Intracerebral hemorrhage (IH) and cephalalgia are common consequences of traumatic brain injury. One of the primary obstacles for patient recovery is the paucity of treatments to support an appropriate analgesic protocol. The present study aimed to assess pain and motor behaviors following different doses of fentanyl on a rat model of IH. METHODS: Twenty-one male Sprague Dawley rats underwent a stereotaxic surgery to produce a collagenase-induced IH in the right caudoputamen nucleus...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27873347/infantile-hemangioma-with-minimal-or-arrested-growth-further-observations-on-clinical-and-histopathologic-findings-of-this-unique-but-underrecognized-entity
#10
Ellen Hui Ma, Susan J Robertson, Chung W Chow, Philip S Bekhor
BACKGROUND: Infantile hemangioma (IH) with minimal or arrested growth (IH-MAG) is becoming increasingly recognized in the literature. It is important to be aware of their existence, because the correct diagnosis is essential for prognostication and treatment and, in the case of facial segmental lesions, the direction of further investigations if PHACE (posterior fossa abnormalities and other structural brain abnormalities; hemangioma(s) of the cervical facial region; arterial cerebrovascular anomalies; cardiac defects, aortic coarctation, and other aortic abnormalities; eye anomalies) syndrome or Sturge-Weber syndrome is suspected...
November 22, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27866331/photoreceptor-degeneration-by-intravitreal-injection-of-n-methyl-n-nitrosourea-mnu-in-rabbits-a-pilot-study
#11
Sarah Rösch, Claudia Werner, Frank Müller, Peter Walter
BACKGROUND: Pilot study on the attempt to induce selective photoreceptor degeneration in the rabbit eye by intravitreal injection of MNU, facing the difficulties of the evaluation of retinal degeneration by different in-vivo and in-vitro methods in such a large eye animal model. METHODS: Eight pigmented Chinchilla Bastard rabbits were injected intravitreally with MNU (1 × 1mg/kg body weight (BW), 1 × 2mg/kg BW, 3 × 3mg/kg BW, 1 × 4mg/kg BW, 1 × 6mg/kg BW, and 1 × DMSO + PBS as control)...
November 19, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27865546/french-consensus-management-of-patients-with-hypersomnia-which-strategy
#12
R Lopez, I Arnulf, X Drouot, M Lecendreux, Y Dauvilliers
Central hypersomnias principally involves type 1 narcolepsy (NT1), type 2 narcolepsy (NT2) and idiopathic hypersomnia (IH). Despite great progress made in understanding the physiopathology of NT1 with low cerebrospinal fluid hypocretin-1 levels, current treatment remains symptomatic. The same applies to NT2 and IH, for which the physiopathology is still largely unknown. Controlling excessive daytime sleepiness (EDS), cataplexy, hypnagogic hallucinations, sleep paralysis and disturbed night-time sleep are key therapeutic targets in NT1...
November 16, 2016: Revue Neurologique
https://www.readbyqxmd.com/read/27864522/comorbidity-between-central-disorders-of-hypersomnolence-and-immune-based-disorders
#13
Lucie Barateau, Régis Lopez, Isabelle Arnulf, Michel Lecendreux, Patricia Franco, Xavier Drouot, Smaranda Leu-Semenescu, Isabelle Jaussent, Yves Dauvilliers
OBJECTIVE: To assess and compare the frequencies of personal and family history of autoimmune diseases (AID), autoinflammatory disorders (ID), and allergies in a population of patients, adults and children, with narcolepsy type 1 (NT1), narcolepsy type 2 (NT2), and idiopathic hypersomnia (IH), 3 central hypersomnia disorders, and healthy controls. METHODS: Personal and family history of AID, ID, and allergies were assessed by questionnaire and medical interview in a large cohort of 450 consecutive adult patients (206 NT1, 106 NT2, 138 IH) and 95 pediatric patients (80 NT1) diagnosed according to the third International Classification of Sleep Disorders criteria in national reference centers for narcolepsy in France and 751 controls (700 adults, 51 children) from the general population...
November 18, 2016: Neurology
https://www.readbyqxmd.com/read/27859976/fatigue-failure-of-narrow-implants-with-different-implant-abutment-connection-designs
#14
Dimorvan Bordin, Lukasz Witek, Vinícius P Fardin, Estevam A Bonfante, Paulo G Coelho
PURPOSE: To evaluate the reliability of narrow diameter dental implants (NDIs) with similar macrogeometry and 3 implant-abutment connection designs. MATERIALS AND METHODS: Eighty-four NDIs (3.5 × 10 mm) were selected and divided into 4 groups (n = 21/group) according to implant-abutment connection design, as follows: EH - external hexagon, IH - internal hexagon, IC - internal conical, and IC-M - internal conical connected to a monolithic titanium abutment. Identical abutments were torqued to the implants, and standardized maxillary incisor crowns were cemented and subjected to step-stress accelerated life testing (SSALT) in water...
November 18, 2016: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/27859912/sweating-responses-to-isometric-handgrip-exercise-and-forearm-muscle-metaboreflex-in-prepubertal-children-and-elderly
#15
Tatsuro Amano, Seiko Kai, Michi Nakajima, Tomoko Ichinose-Kuwahara, Nicola Gerrett, Narihiko Kondo, Yoshimitsu Inoue
The purpose of the present study is to investigate sweating responses to isometric handgrip (IH) exercise and muscle metaboreflex in prepubertal children and the elderly. In hot condition (ambient temperature, 35°C; relative humidity, 45%), 13 healthy young adults, 10 prepubertal children, and 10 elderly (age: 20.4±1.2, 11.4±0.5, and 63.5±3.1 years, respectively) repeated three handgrip-exercise protocol that consisted of 1 min IH exercise at 15, 30, or 45% of maximum voluntary contractions (MVC) followed by 2 min post-exercise forearm occlusion...
November 11, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27859607/a-new-method-for-evaluation-of-the-autonomic-nervous-system-in-patients-with-idiopathic-hyperhidrosis-systolic-blood-pressure-and-heart-rate-recovery-after-graded-exercise
#16
Y I Alihanoglu, B S Yildiz, I D Kilic, A Saricopur, M Oncu, I Buber, L Tasli, H Evrengul
BACKGROUND: Idiopathic hyperhidrosis (IH) is characterized by excessive and uncontrolled production of sweat, mainly localized to the soles, palms, axillae and craniofacial area. Although IH is a disease concerning the autonomic nervous system, it is not clear yet whether this dysfunction is local or systemic. OBJECTIVE: To evaluate the autonomic control of cardiovascular system by measuring values of heart rate recovery (HRR) and systolic blood pressure recovery (SBPR) obtained at various time intervals after maximal graded exercise treadmill testing in patients with IH compared with controls...
December 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27857076/3d-visualization-of-additive-occlusion-and-tunable-full-spectrum-fluorescence-in-calcite
#17
David C Green, Johannes Ihli, Paul D Thornton, Mark A Holden, Bartosz Marzec, Yi-Yeoun Kim, Alex N Kulak, Mark A Levenstein, Chiu Tang, Christophe Lynch, Stephen E D Webb, Christopher J Tynan, Fiona C Meldrum
From biomineralization to synthesis, organic additives provide an effective means of controlling crystallization processes. There is growing evidence that these additives are often occluded within the crystal lattice. This promises an elegant means of creating nanocomposites and tuning physical properties. Here we use the incorporation of sulfonated fluorescent dyes to gain new understanding of additive occlusion in calcite (CaCO3), and to link morphological changes to occlusion mechanisms. We demonstrate that these additives are incorporated within specific zones, as defined by the growth conditions, and show how occlusion can govern changes in crystal shape...
November 18, 2016: Nature Communications
https://www.readbyqxmd.com/read/27854553/mortality-among-hospitalized-patients-with-hypoglycemia-insulin-related-and-non-insulin-related
#18
A Akirov, A Grossman, T Shochat, I Shimon
CONTEXT: Hypoglycemia is common among hospitalized patients with and without diabetes mellitus (DM) but the prognostic implications may differ with spontaneous versus insulin-related hypoglycemia. OBJECTIVE: Investigate the association between spontaneous or insulin-related hypoglycemia and mortality in hospitalized patients. DESIGN: Hypoglycemia was defined as blood glucose <70mg/dl (3.9 mmol/l), including moderate hypoglycemia (40-70mg/dl, 2...
November 17, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27853461/snp-based-linkage-mapping-for-validation-of-qtls-for-resistance-to-ascochyta-blight-in-lentil
#19
Shimna Sudheesh, Matthew S Rodda, Jenny Davidson, Muhammad Javid, Amber Stephens, Anthony T Slater, Noel O I Cogan, John W Forster, Sukhjiwan Kaur
Lentil (Lens culinaris Medik.) is a self-pollinating, diploid, annual, cool-season, food legume crop that is cultivated throughout the world. Ascochyta blight (AB), caused by Ascochyta lentis Vassilievsky, is an economically important and widespread disease of lentil. Development of cultivars with high levels of durable resistance provides an environmentally acceptable and economically feasible method for AB control. A detailed understanding of the genetic basis of AB resistance is hence highly desirable, in order to obtain insight into the number and influence of resistance genes...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27844056/hyperpolarization-activated-currents-and-subthreshold-resonance-in-granule-cells-of-the-olfactory-bulb
#20
Ruilong Hu, Katie A Ferguson, Christina B Whiteus, Dimphna H Meijer, Ricardo C Araneda
An important contribution to neural circuit oscillatory dynamics is the ongoing activation and inactivation of hyperpolarization-activated currents (Ih). Network synchrony dynamics play an important role in the initial processing of odor signals by the main olfactory bulb (MOB) and accessory olfactory bulb (AOB). In the mouse olfactory bulb, we show that Ih is present in granule cells (GCs), the most prominent inhibitory neuron in the olfactory bulb, and that Ih underlies subthreshold resonance in GCs. In accord with the properties of Ih, the currents exhibited sensitivity to changes in extracellular K(+) concentration and ZD7288 (4-ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidin chloride), a blocker of Ih...
September 2016: ENeuro
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