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https://www.readbyqxmd.com/read/29234938/impact-of-incisional-hernia-development-following-abdominal-operations-on-total-healthcare-cost
#1
Vamsi V Alli, Jianying Zhang, Dana A Telem
BACKGROUND: Introduction of the category III CPT code (0437T) for prophylactic mesh augmentation (PMA) highlights efforts to reduce incisional hernia (IH). PMA's value in the context of value-based care requires understanding both the cost of IH development and the savings from prevention. We hypothesized large healthcare costs with IH development. Appreciating which subsets of patients are at highest risk for IH, and the subsets who have the costliest care is essential in targeting interventions for hernia prevention...
December 12, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29233741/cyclooxygenase-enzyme-activity-does-not-impair-respiratory-motor-plasticity-after-one-night-of-intermittent-hypoxia
#2
Adrianne G Huxtable, Elizabeth Kopp, Brendan J Doughtery, Jyoti J Watters, Gordon S Mitchell
Although inflammation is prevalent in many clinical disorders challenging breathing, we are only beginning to understand the impact of inflammation on neural mechanisms of respiratory control. We recently demonstrated one form of respiratory motor plasticity is extremely sensitive to even mild inflammation induced by a single night (8hours) of intermittent hypoxia (IH-1), mimicking aspects of obstructive sleep apnea. Specifically, phrenic long-term facilitation (pLTF) following moderate acute intermittent hypoxia (AIH) is abolished by IH-1, but restored by high doses of the non-steroidal anti-inflammatory drug, ketoprofen...
December 9, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29230549/a-nationwide-survey-of-incidence-rates-and-risk-factors-of-inguinal-hernia-in-preterm-children
#3
Yu-Wei Fu, Mei-Lien Pan, Yao-Jen Hsu, Tai-Wai Chin
PURPOSE: Clinical observations showed a higher incidence rate of inguinal hernia (IH) in preterm infants. In this study, we calculated the incidence rate of preterm IH from the National Health Insurance Research Database (NHIRD) of Taiwan. METHODS: From NHIRD, 92,308 subjects born in the year of 1997-2005 were randomly selected as the study cohort. The medical claims of these subjects from birth to 6th year of age were analyzed. Preterm births were defined using ICD code 765...
December 11, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/29227657/density-functional-tight-binding-molecular-dynamics-simulations-of-excess-proton-diffusion-in-ice-ih-ice-ic-ice-iii-and-melted-ice-vi-phases
#4
Aditya Wibawa Sakti, Yoshifumi Nishimura, Chien-Pin Chou, Hiromi Nakai
The structural, dynamical, and energetic properties of the excess proton in ice were studied using density-functional tight-binding molecular dynamics simulations. The ice systems investigated herein consisted of low-density hexagonal and cubic crystalline variants (ice Ih and Ic) and high-density structures (ice III and melted ice VI). Analysis of the temperature dependence of radial distribution function and bond order parameters served to characterize the distribution and configuration of hundreds of water molecules in a unit cell...
December 11, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29222565/biomechanics-and-mechanobiology-of-saphenous-vein-grafts
#5
Keith Gooch, Michael Firstenberg, Brittany Shrefler, Benjamin Scandling
Within several weeks of use as coronary artery bypass grafts (CABG), saphenous veins (SV) exhibit significant intimal hyperplasia (IH). The fact that SV do not develop significant IH in their native venous environment coupled with the rapidity with which they develop IH following grafting into the arterial circulation suggests that factors associated with the isolation and preparation of SV and/or differences between the venous and arterial environments contribute to disease progression. There is strong evidence suggesting that mechanical trauma associated with traditional techniques of SV preparation can significantly damage the vessel and might potentially reduce graft patency though modern surgical techniques reduces these injuries...
December 9, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29220729/comparison-of-dynamic-cervical-implant-versus-anterior-cervical-discectomy-and-fusion-for-the-treatment-of-single-level-cervical-degenerative-disc-disease-a-five-year-follow-up
#6
Ce Zhu, Xi Yang, Lei Wang, Bo-Wen Hu, Li-Min Liu, Lin-Nan Wang, Hao Liu, Yue-Ming Song
OBJECTIVE: To compare clinical and radiographic outcomes of dynamic cervical implant(DCI) with anterior cervical discectomy and fusion(ACDF) in the treatment of single-level cervical degenerative disc disease (CDDD) 5 years after surgery. PATIENTS AND METHODS: Forty-three patients with DCI were matched one-to-one with patients with ACDF based on age, gender, and operative segment in this retrospective study. All patients had been followed up for more than 5 years...
December 5, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29217058/management-of-infantile-hemangiomas-of-the-airway
#7
REVIEW
David H Darrow
Infantile hemangiomas (IHs) of the airway are far less common than their cutaneous counterparts, and their symptoms mimic those of viral croup. As a result, by the time these lesions are diagnosed, they are often advanced and causing airway compromise. Fortunately, the evolution of propranolol as an effective and safe pharmacotherapy has simplified management of IH and reduced the likelihood of complications previously seen with steroid therapy and surgery. Nevertheless, the otolaryngologist must be prepared with an alternate plan to manage lesions refractory to pharmacotherapy...
February 2018: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/29206849/cilostazol-attenuates-intimal-hyperplasia-in-a-mouse-model-of-chronic-kidney-disease
#8
Wiwat Chancharoenthana, Asada Leelahavanichkul, Sujittra Taratummarat, Jutamas Wongphom, Khajohn Tiranathanagul, Somchai Eiam-Ong
Intimal hyperplasia (IH) is a common cause of vasculopathy due to direct endothelial damage (such as post-coronary revascularization) or indirect injury (such as chronic kidney disease, or CKD). Although the attenuation of coronary revascularization-induced IH (direct-vascular-injury-induced IH) by cilostazol, a phosphodiesterase III inhibitor, has been demonstrated, our understanding of the effect on CKD-induced IH (indirect-vascular-injury-induced IH) is limited. Herein, we tested if cilostazol attenuated CKD-induced IH in a mouse model of ischemic-reperfusion injury with unilateral nephrectomy (Chr I/R), a normotensive non-proteinuria CKD model...
2017: PloS One
https://www.readbyqxmd.com/read/29195283/multiple-trapping-model-of-dielectric-relaxation-of-the-ice-ih
#9
A A Khamzin, R R Nigmatullin
A microscopic theory of dielectric relaxation of the hexagonal ice (Ih) is proposed based on the multiple-trapping model. The theory explains the distinctive peculiarities of the relaxation time temperature behavior and the peak broadening parameter in a wide temperature range from the unified positions.
November 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29193649/infantile-hemangioma-pathogenesis-and-mechanisms-of-action-of-propranolol
#10
REVIEW
Anita Rotter, Zilda Najjar Prado de Oliveira
Infantile hemangioma (IH) is the most common benign tumor of childhood, with a prevalence of 4 % to 10 %. It is characterized by a proliferative rapid growth phase, which starts after a few weeks of life, followed by a slow regression phase. In IH cases that are potentially disfiguring or life-threatening (10 % to 15 % of all cases), systemic therapy should be promptly initiated. Data source The present study reviews published scientific articles available in reliable electronic databases. Selected were all studies that evaluated the pathogenesis of IH and the mechanisms of action of propranolol...
November 28, 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29193336/very-high-spin-ground-states-in-matryoshka-actinide-nanoclusters-a-computational-study
#11
Hanshi Hu, Nikolas Kaltsoyannis
Inspired by the experimentally synthesized Na12@[(UO2)(O2)1.5]208- ("Na12@U20") cluster, we have explored computationally the substitution of the Na cations by many other metals. 6 other M12@U20 systems are found to be stable (M = K+, Rb+, Cs+, Ag+, Mg2+, Fe2+). For 3 of these (Mg2+, Ag+ and Na+), the cluster can supporta group 16 dianion at its centre, forming a new type of Matryoshka ("Russian Doll") actinide nanocluster E@M12@U20 (E = S2-, Se2-, Te2- and Po2-). These systems have 3 shell, onion like geometries with nearly perfect Ih symmetry...
November 28, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29192323/significant-inhibition-of-infantile-hemangioma-growth-by-sustained-delivery-of-urea-from-liposomes-in-microspheres
#12
Xiaoshuang Zhu, Xiaonan Guo, Dakan Liu, Yubin Gong, Jin Sun, Changxian Dong
Infantile hemangioma (IH) is a benign pediatric tumor, and rapid growth of IH can result in serious morbidity and even mortality. Only one drug Hemangeol™ (propranolol hydrochloride oral solution) has been approved for the treatment of IH, whereas patients suffer from its adverse effects and high frequency of administration. We have used urea, an organic compound and a normal body metabolite, in the treatment of IH for 20 years, and demonstrated that urea is an effective and well-tolerated treatment for IH...
January 2018: Oncology Reports
https://www.readbyqxmd.com/read/29189030/a-weekly-diary-study-of-minority-stress-coping-and-internalizing-symptoms-among-gay-men
#13
Brian A Feinstein, Joanne Davila, Christina Dyar
OBJECTIVE: Research has demonstrated that gay men are at increased risk for internalizing disorders compared with heterosexual men and that minority stressors are risk factors. However, the mechanisms underlying the associations between minority stressors and internalizing symptoms remain unclear. The current study examined coping strategies (active and disengaged coping) as mediators of the associations between minority stressors (internalized homonegativity [IH] and rejection sensitivity [RS]) and internalizing symptoms...
December 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/29188379/inguinal-hernia-repair-by-bianchi-incision-in-boys-a-retrospective-study
#14
Junshan Lin, Dumiao Li, Jinwen Chen, Li Lin, Yali Xu
OBJECTIVE: Open inguinal hernia repair by Bianchi incision is a potential alternative technique for the treatment of IH. This study aims to retrospectively analyze boys with IH, who underwent open IH repair by Bianchi incision. METHODS: A total of 3300 boys (1-144 months) with IH from April 2007 to September 2015 were enrolled into this study. An open high scrotal incision (Bianchi incision) to ligate the processus proximal to the internal inguinal ring was performed in patients for IH repair...
November 29, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/29187553/ih-interacts-with-somato-dendritic-structure-to-determine-frequency-response-to-weak-alternating-electric-field-stimulation
#15
Enrique H S Toloza, Ehsan Negahbani, Flavio Frohlich
Transcranial current stimulation (tCS) modulates brain dynamics using weak electric fields. Given the pathological changes in brain network oscillations in neurological and psychiatric illnesses, using alternating electric field waveforms that engage rhythmic activity has been proposed as a targeted, network-level treatment approach. Previous studies have investigated the effects of electric fields at the neuronal level. However, the biophysical basis of the cellular response to electric fields has remained limited...
November 29, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29187386/high-incidence-of-atrial-fibrillation-after-embolic-stroke-of-undetermined-source-in-posterior-cerebral-artery-territory
#16
Hisaki Makimoto, Muhammed Kurt, Michael Gliem, John-Ih Lee, Jan Schmidt, Patrick Müller, Lukas Clasen, Christoph Brinkmeyer, Dong-In Shin, Sebastian Jander, Malte Kelm, Alexander Fürnkranz
BACKGROUND: Subclinical atrial fibrillation is one possible cause of embolic stroke of undetermined source (ESUS). It remains to be elucidated if a specific infarction site has a predictive value for detecting subclinical atrial fibrillation. We aimed to investigate the predictive value of infarction site in patients with ESUS for the detection of atrial tachyarrhythmia (AT) using an insertable cardiac monitor. METHODS AND RESULTS: Consecutive 146 patients (84 men; aged 62±12 years) underwent insertable cardiac monitor implantation after diagnosis of ESUS...
November 29, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29174411/gestational-intermittent-hypoxia-increases-susceptibility-to-neuroinflammation-and-alters-respiratory-motor-control-in-neonatal-rats
#17
REVIEW
Stephen M Johnson, Karanbir S Randhawa, Jenna J Epstein, Ellen Gustafson, Austin D Hocker, Adrianne G Huxtable, Tracy L Baker, Jyoti J Watters
Sleep disordered breathing (SDB) and obstructive sleep apnea (OSA) during pregnancy are growing health concerns because these conditions are associated with adverse outcomes for newborn infants. SDB/OSA during pregnancy exposes the mother and the fetus to intermittent hypoxia. Direct exposure of adults and neonates to IH causes neuroinflammation and neuronal apoptosis, and exposure to IH during gestation (GIH) causes long-term deficits in offspring respiratory function. However, the role of neuroinflammation in CNS respiratory control centers of GIH offspring has not been investigated...
November 22, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29171922/less-means-more-the-magnitude-of-synaptic-plasticity-along-the-hippocampal-dorso-ventral-axis-is-inversely-related-to-the-expression-levels-of-plasticity-related-neurotransmitter-receptors
#18
Valentyna Dubovyk, Denise Manahan-Vaughan
The dorsoventral axis of the hippocampus exhibits functional differentiations with regard to (spatial Vs emotional learning) and information retention (rapid encoding Vs long-term storage), as well as its sensitivity to neuromodulation and information received from extrahippocampal structures. The mechanisms that underlie these differentiations remain unclear. Here, we explored neurotransmitter receptor expression along the dorsoventral hippocampal axis and compared hippocampal synaptic plasticity in the CA1 region of the dorsal (DH), intermediate (IH) and ventral hippocampi (VH)...
November 24, 2017: Hippocampus
https://www.readbyqxmd.com/read/29171483/-intermittent-hypoxia-due-to-sleep-apnea-syndrome-in-patients-with-type-2-diabetes-mellitus
#19
D I Burchakov, A Yu Mayorov
OBJECTIVES: To evaluate the possible association between intermittent hypoxia (IH) and HbA1c in patients with insufficient control type of 2 diabetes mellitus (T2DM). MATERIAL AND METHODS: In this cross-sectional study 183 patients with HbAc1≥7% underwent three-channel overnight monitoring (ApneaLink) and completed Berlin Questionnaire, Epworth Sleepiness Scale and Pittsburgh Sleep Quality Index. Patients were divided in two groups, based on the cut-off value of oxygen desaturation index≥15...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29170470/switchable-photovoltaic-windows-enabled-by-reversible-photothermal-complex-dissociation-from-methylammonium-lead-iodide
#20
Lance M Wheeler, David T Moore, Rachelle Ihly, Noah J Stanton, Elisa M Miller, Robert C Tenent, Jeffrey L Blackburn, Nathan R Neale
Materials with switchable absorption properties have been widely used for smart window applications to reduce energy consumption and enhance occupant comfort in buildings. In this work, we combine the benefits of smart windows with energy conversion by producing a photovoltaic device with a switchable absorber layer that dynamically responds to sunlight. Upon illumination, photothermal heating switches the absorber layer-composed of a metal halide perovskite-methylamine complex-from a transparent state (68% visible transmittance) to an absorbing, photovoltaic colored state (less than 3% visible transmittance) due to dissociation of methylamine...
November 23, 2017: Nature Communications
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