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https://www.readbyqxmd.com/read/29445526/intermittent-hypoxia-cardiovascular-disease-and-obstructive-sleep-apnoea
#1
REVIEW
Chris D Turnbull
Obstructive sleep apnoea (OSA) is a common disorder and is associated with cardiovascular disease. Continuous positive airway pressure (CPAP), whilst reducing blood pressure, has not been shown to reduce cardiovascular events when used as a treatment solely for this purpose in patients with previous cardiovascular disease. Developing a better understanding of the mechanisms underlying cardiovascular disease in OSA is important to develop new treatments. Potential causative mechanisms for cardiovascular disease in OSA include arousal induced sympathetic activation, large intrathoracic pressure swings leading to shear stress on the heart and great vessels, and intermittent hypoxia (IH)...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29445096/chronic-intermittent-hypoxia-promotes-myocardial-ischemia-related-ventricular-arrhythmias-and-sudden-cardiac-death
#2
Jessica Morand, Claire Arnaud, Jean-Louis Pepin, Diane Godin-Ribuot
We investigated the effects of intermittent hypoxia (IH), such as that encountered in severe obstructive sleep apnea (OSA) patients, on the development and severity of myocardial ischemia-related ventricular arrhythmias. Rats were exposed to 14 days of IH (30 s at 5%O 2 and 30 s at 21%O 2 , 8 h·day -1 ) or normoxia (N, similar air-air cycles) and submitted to a 30-min coronary ligature. Arterial blood pressure (BP) and ECG were recorded for power spectral analysis, ECG interval measurement and arrhythmia quantification...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29442057/inguinal-hernia-repair-in-day-surgery-the-role-of-mac-monitored-anesthesia-care-with-remifentanil
#3
P Palumbo, S Usai, C Amatucci, B Perotti, L Ruggeri, G Illuminati, G Tellan
BACKGROUND: The extension of indications for procedures in a Day Surgery (DS) setting has led to changes in the anesthetic and surgical treatment of Inguinal Hernias (IH). According to the recommendations of the European Hernia Society, the treatment of IH in DS units should be performed under Monitored Anesthesia Care (MAC). PATIENTS AND METHODS: 960 patients underwent IH repairs over a period of 24 months. The patients were randomly divided into two groups: R (remifentanil) and F (fentanyl); the group F was considered as a control group...
November 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29438820/intraoperative-hippocampal-electrocorticography-frequently-captures-electrographic-seizures-and-correlates-with-hippocampal-pathology
#4
Aashit K Shah, Darren Fuerst, Sandeep Mittal
OBJECTIVE: Relationship between electrographic seizures on hippocampal electrocorticography (IH-ECoG) and presence/type of hippocampal pathology remains unclear. METHODS: IH-ECoG was recorded for 10-20 min from the ventricular surface of the hippocampus following removal of the temporal neocortex in 40 consecutive patients. Correlation between intraoperative hippocampal seizures and preoperative MRI, hippocampal histopathology, and EEG from invasive monitoring was determined...
February 2, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29436607/decreased-hyperpolarization-activated-cyclic-nucleotide-gated-channels-are-involved-in-bladder-dysfunction-associated-with-spinal-cord-injury
#5
Qian Liu, Chao Wu, Shengquan Huang, Qingjian Wu, Tao Zhou, Xiaobing Liu, Xin Liu, Xiaoyan Hu, Longkun Li
Spinal cord injury (SCI) leads to bereft voluntary control of bladder, but the possible role of spontaneous excited system in bladder of SCI patients is poorly understood. Hyper-polarization-activated cyclic nucleotide-gated (HCN) channels are deemed to regulate the spontaneous contraction of bladder, our study explored the functional role of HCN channels in SCI induced neurogenic bladder. Sixty female Sprague-Dawley rats were randomized into control, sham and SCI groups. Rat models subjected to SCI at S2 levels were successfully established and were assessed using hematoxylin and eosin staining and cystometry...
February 13, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29433520/intermittent-hypoxia-promotes-melanoma-lung-metastasis-via-oxidative-stress-and-inflammation-responses-in-a-mouse-model-of-obstructive-sleep-apnea
#6
Lian Li, Fangyuan Ren, Chao Qi, Leiqian Xu, Yinshan Fang, Maoli Liang, Jing Feng, Baoyuan Chen, Wen Ning, Jie Cao
BACKGROUND: Recently, increased tumor incidence and cancer-related mortality have been reported among patients with obstructive sleep apnea (OSA). Intermittent hypoxia (IH), the hallmark feature of OSA, contributes to the metastasis of tumors. However, the molecular mechanisms by which tumor metastasis is accelerated by OSA-like IH remain to be elucidated. METHODS: C57BL/6 J male mice were subjected to intravenous injection of B16F10 melanoma cells before receiving IH treatment...
February 12, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29432418/spike-and-burst-coding-in-thalamocortical-relay-cells
#7
Fleur Zeldenrust, Pascal Chameau, Wytse J Wadman
Mammalian thalamocortical relay (TCR) neurons switch their firing activity between a tonic spiking and a bursting regime. In a combined experimental and computational study, we investigated the features in the input signal that single spikes and bursts in the output spike train represent and how this code is influenced by the membrane voltage state of the neuron. Identical frozen Gaussian noise current traces were injected into TCR neurons in rat brain slices as well as in a validated three-compartment TCR model cell...
February 12, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29430864/blending-non-group-iiib-transition-metal-and-rare-earth-metal-into-a-c80-fullerene-cage-with-d5h-symmetry-which-metal-is-decisive
#8
Shangfeng Yang, Tao Wei, Fei Jin, Runnan Guan, Jing Huang, Muqing Chen, Qunxiang Li
Rare earth metals have been mostly entrapped into fullerene cage to form endohedral clusterfullerenes, whereas the reported non-Group-IIIB transition metals which can form clusterfullerenes are quite limited to titanium (Ti) and vanadium (V), and both are exclusively entrapped within an Ih-C80 cage. Herein, we report the first non-Group-IIIB transition metal-containing endohedral fullerenes based on a C80 cage with D5h symmetry - VxSc3-xN@D5h-C80 (x=1, 2), which exhibit two variable cluster compositions. The molecular structure of VSc2N@D5h-C80 was unambiguously determined by X-ray crystallography...
February 11, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29429652/a-selective-synthesis-of-the-fullerene-fused-dioxane-adduct-via-heterogeneous-reaction-of-c60-with-%C3%AE-diols-and-naoh-under-ultrasonication
#9
Zemfira S Kinzyabaeva, Glus L Sharipov
A novel ultrasonic-mediated approach to the synthesis of 1,9-dihydro[C60-Ih][5,6](1,4-dioxano)fullerene based on the heterogeneous reaction of fullerene with α-diols and NaOH has been developed. It allows producing the fullerene derivatives with high yields and selectivity.
April 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29428038/incisional-hernia-in-the-united-states-trends-in-hospital-encounters-and-corresponding-healthcare-charges
#10
Valeriy Shubinets, Justin P Fox, Michael A Lanni, Michael G Tecce, Eric M Pauli, William W Hope, Stephen J Kovach, John P Fischer
Incisional hernia (IH) is a challenging, potentially morbid condition. This study evaluates recent trends in hospital encounters associated with IH care in the United States. Using Nationwide Inpatient Sample databases from 2007 to 2011, annual estimates of IH-related hospital discharges, charges, and serious adverse events were identified. Significance in observed trends was tested using regression modeling. From 2007 to 2011, there were 583,054 hospital discharges associated with a diagnosis of IH. 81.1 per cent had a concurrent procedure for IH repair...
January 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29428035/the-state-of-prophylactic-mesh-augmentation
#11
Michael A Lanni, Michael G Tecce, Valeriy Shubinets, Michael N Mirzabeigi, John P Fischer
Prophylactic mesh augmentation (PMA) is the implantation of mesh during closure of an index laparotomy to decrease a patient's risk for developing incisional hernia (IH). The current body of evidence lacks refined guidelines for patient selection, mesh placement, and material choice. The purpose of this study is to summarize the literature and identify areas of research needed to foster responsible and appropriate use of PMA as an emerging technique. We conducted a comprehensive review of Scopus, Cochrane, PubMed, and <ext-link ext-link-type="uri" xlink:href="http://clinicaltrials...
January 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29427463/salivary-levels-of-angiopoietin-2-in-infants-with-infantile-hemangiomas-treated-with-and-without-systemic-propranolol
#12
Alexandra Seamens, Elizabeth Nieman, Kristen Losavio, Bridget Bradley, Kate Nelson, Kuang-Ho Chen, Suephy Chen, Jack Arbiser, Leslie P Lawley
BACKGROUND: Infantile hemangiomas (IH) with functional or cosmetic concerns necessitate systemictreatment for which propranolol is the preferred treatment. However, the mechanism ofaction is unknown. Mouse models suggest the angiopoietin-2 (Ang2)/Tie-2 system isimplicated. Ang2 can promote endothelial growth or induce apoptosis depending on thepresence of vascular endothelial growth factor (VEGF). This pilot study investigates thesaliva Ang2 levels in infants with IH treated with and without systemic propranolol...
February 10, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29427087/neuroinflammation-alters-integrative-properties-of-rat-hippocampal-pyramidal-cells
#13
Federica Frigerio, Corey Flynn, Ye Han, Kyle Lyman, Joaquin N Lugo, Teresa Ravizza, Antoine Ghestem, Julika Pitsch, Albert Becker, Anne E Anderson, Annamaria Vezzani, Dane Chetkovich, Christophe Bernard
Neuroinflammation is consistently found in many neurological disorders, but whether or not the inflammatory response independently affects neuronal network properties is poorly understood. Here, we report that intracerebroventricular injection of the prototypical inflammatory molecule lipopolysaccharide (LPS) in rats triggered a strong and long-lasting inflammatory response in hippocampal microglia associated with a concomitant upregulation of Toll-like receptor (TLR4) in pyramidal and hilar neurons. This, in turn, was associated with a significant reduction of the dendritic hyperpolarization-activated cyclic AMP-gated channel type 1 (HCN1) protein level while Kv4...
February 9, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29408835/incidence-and-factors-correlating-with-incisional-hernia-following-open-bowel-resection-in-patients-with-inflammatory-bowel-disease-a-review-of-1000-patients
#14
Tomas M Heimann, Santosh Swaminathan, Adrian J Greenstein, Randolph M Steinhagen
OBJECTIVE: The aim of this study was to identify the incidence and factors associated with the development of incisional hernia (IH) in patients with inflammatory bowel disease (IBD) undergoing open bowel resections. BACKGROUND: Predisposing factors for IH have not been well studied in patients with IBD undergoing open bowel resection. The role of duration of the disease, nutritional factors, anti-inflammatory treatment, previous operative procedures, wound infection, and other complicating factors remains unclear...
March 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29406756/fourier-transform-surface-plasmon-resonance-of-nanodisks-embedded-in-magnetic-nanorods
#15
Insub Jung, Seongkeun Ih, Haneul Yoo, Seunghun Hong, Sungho Park
In this study, we demonstrate the synthesis and application of magnetic plasmonic gyro-nanodisks (GNDs) for Fourier transform surface plasmon resonance-based biodetection. Plasmonically-active and magnetically-responsive gyro-nanodisks were synthesized using electrochemical methods with anodized aluminum templates. Due to the unique properties of GNDs (magnetic responsiveness and surface plasmon bands), periodic extinction signals were generated under an external rotating magnetic field, which is in turn converted into frequency domains using Fourier-transform...
February 6, 2018: Nano Letters
https://www.readbyqxmd.com/read/29403429/alzheimer-s-disease-mutant-mice-exhibit-reduced-brain-tissue-stiffness-compared-to-wild-type-mice-in-both-normoxia-and-following-intermittent-hypoxia-mimicking-sleep-apnea
#16
Maria José Menal, Ignasi Jorba, Marta Torres, Josep M Montserrat, David Gozal, Anna Colell, Gerard Piñol-Ripoll, Daniel Navajas, Isaac Almendros, Ramon Farré
Background: Evidence from patients and animal models suggests that obstructive sleep apnea (OSA) may increase the risk of Alzheimer's disease (AD) and that AD is associated with reduced brain tissue stiffness. Aim: To investigate whether intermittent hypoxia (IH) alters brain cortex tissue stiffness in AD mutant mice exposed to IH mimicking OSA. Methods: Six-eight month old (B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J) AD mutant mice and wild-type (WT) littermates were subjected to IH (21% O2 40 s to 5% O2 20 s; 6 h/day) or normoxia for 8 weeks...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29398507/anti-h-antibody-of-unusually-high-titer-showing-variable-reactivities-against-group-a-red-cells-and-broad-thermal-amplitude-in-a-patient-with-lymphoma
#17
Seung Jun Choi, Hoon Seok Kim, Jaewoong Lee, Young-Sun Song, Jihyang Lim
We report a case of a patient with high titer anti-H antibody showing broad thermal amplitude and variable reactivities against group A red cells. A 62-year-old Korean female was diagnosed with diffuse large B cell lymphoma involving multiple organs. Her ABO/RhD type was A+ and her genotype was ABO*A.01.01/ABO*O.01.02. Antibody screening test (AST) and antibody identification test (IDT) were strongly positive for all reagent cells. Anti-human globulin (AHG) test revealed an antibody titer of 1:256 for 37 °C phase and trace positivity for poly- and mono-specific C3d...
January 3, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29397372/conducting-an-integrative-health-interview
#18
Maureen George, Melissa Avila, Thomas Speranger, Heidi K Bailey, William S Silvers
Complementary medicine incorporates the use of non-evidence-based complementary modalities into conventional (Western) medicine. Alternative medicines are approaches that are used in place of conventional medicine. Integrative medicine is the synthesis of conventional medical treatments with "evidence-based" complementary medical practices. When complementary approaches are incorporated into mainstream health care, it is called integrative health (IH). Among children and adults, IH is common despite not all therapies being safe and/or effective...
January 31, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29389945/intermittent-hypoxia-causes-histological-kidney-damage-and-increases-growth-factor-expression-in-a-mouse-model-of-obstructive-sleep-apnea
#19
Bisher Abuyassin, Mohammad Badran, Najib T Ayas, Ismail Laher
Epidemiological studies demonstrate an association between obstructive sleep apnea (OSA) and accelerated loss of kidney function. It is unclear whether the decline in function is due to OSA per se or to other confounding factors such as obesity. In addition, the structural kidney abnormalities associated with OSA are unclear. The objective of this study was to determine whether intermittent hypoxia (IH), a key pathological feature of OSA, induces renal histopathological damage using a mouse model. Ten 8-week old wild-type male CB57BL/6 mice were randomly assigned to receive either IH or intermittent air (IA) for 60 days...
2018: PloS One
https://www.readbyqxmd.com/read/29383203/over-expression-of-ppar-%C3%AE-2-gene-enhances-the-adipogenic-differentiation-of-hemangioma-derived-mesenchymal-stem-cells-in-vitro-and-in-vivo
#20
Si-Ming Yuan, Yao Guo, Qian Wang, Yuan Xu, Min Wang, Hai-Ni Chen, Wei-Min Shen
Background: Most of infantile hemangiomas involute into fibrofatty tissue in childhood, which indicates adipogenesis during this period. Mesenchymal stem cells (MSCs) contribute to the adipogenesis in IH. In this study, we investigated the effects of overexpression of PPAR-γ2 gene on the adipogenic differentiation of Hemangioma-derived MSCs (Hem-MSCs), and discussed the possibility of targeted therapy via PPAR-γ pathway. Methods: MSCs were isolated from proliferating hemangioma by their selective adhesion to plastic culture dishes...
December 29, 2017: Oncotarget
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