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https://www.readbyqxmd.com/read/29667726/interventions-for-infantile-haemangiomas-of-the-skin
#1
REVIEW
Monica Novoa, Eulalia Baselga, Sandra Beltran, Lucia Giraldo, Ali Shahbaz, Hector Pardo-Hernandez, Ingrid Arevalo-Rodriguez
BACKGROUND: Infantile haemangiomas (previously known as strawberry birthmarks) are soft, raised swellings of the skin that occur in 3% to 10% of infants. These benign vascular tumours are usually uncomplicated and tend to regress spontaneously. However, when haemangiomas occur in high-risk areas, such as near the eyes, throat, or nose, impairing their function, or when complications develop, intervention may be necessary. This is an update of a Cochrane Review first published in 2011...
April 18, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29667677/theoretical-determination-of-adsorption-and-ionisation-energies-of-polycyclic-aromatic-hydrocarbons-on-water-ice
#2
Eric Michoulier, Nadia Ben Amor, Mathias Rapacioli, Jennifer A Noble, Joëlle Mascetti, Céline Toubin, Aude Simon
In dense interstellar environments, Polycyclic Aromatic Hydrocarbons (PAHs) are likely to condense onto or integrate into water ice mantles covering dust grains. Understanding the role of ice in the photo-induced processes involving adsorbed PAHs is therefore a key issue in astrochemistry. This requires (i) the knowledge of PAH-ice interactions, i.e. PAH-ice adsorption energies and local structures at the PAH-ice interface, as well as (ii) the understanding of the fate of electrons in the PAH-ice system upon excitation...
April 18, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29665669/-effects-of-intermittent-hypoxia-exposure-on-renal-tubular-epithelial-cell-injury-and-autophagy-in-rats
#3
C Wang, J Tan, B Y Chen, Q Zhang
Objective: To investigate the effects of intermittent hypoxia (IH) exposure on renal tubular epithelial cell injury and autophagy in rats. Methods: A total of 12 Sprague Dawley (SD) rats were randomly divided into two groups: normal control (NC) group and IH group, with 6 rats in each group. An IH animal model was established to observe the effects of IH on renal tubular epithelial cell damage and autophagy in rats. Microalbumin (mAlb) was detected by immunoturbidimetry. Neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1(KIM-1)in urine were assessed by enzyme-linked immunosorbent assay (ELISA) test...
March 27, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29664206/pedf-vegf-ratio-plays-a-crucial-role-in-the-spontaneous-regression-of-infant-hemangioma-and-the-therapeutic-effect-of-propranolol
#4
Liuqing Zhu, Jinye Xie, Zhenyin Liu, Zhijian Huang, Mao Huang, Haofan Yin, Weiwei Qi, Zhonghan Yang, Ti Zhou, Guoquan Gao, Jing Zhang, Xia Yang
Infantile hemangioma (IH) is a benign tumor that is formed by aberrant angiogenesis and that undergoes spontaneous regression over time. Propranolol, the first-line therapy for IH, inhibits angiogenesis by downregulating the activation of the VEGF pathway, which is hyperactivated in IH. However, this treatment is reportedly ineffective for 10% of tumors, and 19% of patients relapse after propranolol treatment. Both pro-angiogenic and anti-angiogenic factors regulate angiogenesis, and PEDF is the most effective endogenous anti-angiogenic factor...
April 17, 2018: Cancer Science
https://www.readbyqxmd.com/read/29662857/cryohemolysis-erythrocyte-osmotic-fragility-and-supplementary-hematimetric-indices-in-the-diagnosis-of-hereditary-spherocytosis
#5
Ledesma Achem Miryam Emilse, Haro Cecilia, Terán Magdalena María, Mónaco María Eugenia, Issé Blanca Alicia, Sandra Stella Lazarte
Background: Hereditary spherocytosis (HS) is a chronic hemolytic anemia characterized by microspherocytes in the peripheral blood and increased erythrocyte osmotic fragility (EOF). This study evaluated the cryohemolysis test (CHT); initial hemolysis (IH); immediate and incubated hemolysis percentage in 5.5 g/L NaCl (H5.5); mean corpuscular hemoglobin concentration (MCHC); red blood cell distribution width (RDW); and Hb/MCHC, Hb/RDW, and MCHC/RDW ratios for the diagnosis of HS. Methods: Data from 13 patients with HS were evaluated at the Instituto de Bioquímica Aplicada and compared with data from 14 unaffected individuals and 11 patients with anemia due to another etiology...
March 2018: Blood Research
https://www.readbyqxmd.com/read/29660902/effect-of-rho-kinase-inhibitor-fasudil-on-the-expression-et-1-and-no-in-rats-with-hypoxic-pulmonary-hypertension
#6
Xing-Zhen Sun, Shu-Yan Li, Xiang-Yang Tian, Ze Hong, Jia-Xin Li
OBJECTIVE: This study aims to study the effect of Rho kinase inhibitor fasudil on the expression endothelin-1 (ET-1) and nitric oxide (NO) in rats with hypoxic pulmonary hypertension (HPH). METHODS: Twenty-four male SD rats were randomly divided into three groups: control group, model group (HPH group) and HPH+fasudil group. The rat HPH model was established by intermittent hypoxia (IH) at atmospheric pressure. Mean pulmonary artery pressure (mPAP), right ventricular hypertrophy index (RVHI), ET-1 and NO levels, and pulmonary vascular structural changes were observed in all groups...
April 12, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29660281/grand-canonical-investigation-of-the-quasi-liquid-layer-of-ice-is-it-liquid
#7
Ignacio Pickering, Martin Paleico, Yamila A Perez Sirkin, Damian A Scherlis, Matias H Factorovich
In this study, the solid-vapor equilibrium and the quasi liquid layer (QLL) of ice Ih exposing the basal and primary prismatic faces were explored by means of grand canonical molecular dynamics simulations with the monoatomic mW potential. For this model, the solid-vapor equilibrium was found to follow the Clausius Clapeyron relation in the range examined, from 250 K to 270 K, with a ΔHsub of 50 kJ/mol in excellent agreement with the experimental value. The analysis of the crystallization dynamics during condensation and evaporation revealed that, for the basal face, both processes are highly activated, and in particular cubic ice is formed during condensation, producing stacking-disordered ice...
April 16, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29659130/microrna-21-drives-the-switch-to-a-synthetic-phenotype-in-human-saphenous-vein-smooth-muscle-cells
#8
Aliah R Alshanwani, Kirsten Riches-Suman, David J O'Regan, Ian C Wood, Neil A Turner, Karen E Porter
Cardiovascular disease is a leading cause of morbidity and mortality. Smooth muscle cells (SMC) comprising the vascular wall can switch phenotypes from contractile to synthetic, which can promote the development of aberrant remodelling and intimal hyperplasia (IH). MicroRNA-21 (miR-21) is a short, non-coding RNA that has been implicated in cardiovascular diseases including proliferative vascular disease and ischaemic heart disease. However, its involvement in the complex development of atherosclerosis has yet to be ascertained...
April 16, 2018: IUBMB Life
https://www.readbyqxmd.com/read/29658495/internal-hernia-following-robotic-assisted-pancreaticoduodenectomy
#9
Kai Qin, Zhichong Wu, Jiabin Jin, Baiyong Shen, Chenghong Peng
BACKGROUND Robotic assisted pancreaticoduodenectomy (RPD) is reported to be safe and feasible. Internal hernia (IH) after RPD is a serious but rarely reported complication. MATERIAL AND METHODS We retrospectively reviewed data of 231 patients who underwent RPD from October 2010 to December 2016. The incidence, symptoms, time of presentation, and outcome were investigated. RESULTS Five patients (2.6%) were diagnosed with IH. Significant correlation (P<0.001) between IH and transverse mesocolon defect was confirmed...
April 16, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29652858/oncosuppressors-and-oncogenes-role-in-haemangioma-genesis-and-potential-for-therapeutic-targeting
#10
REVIEW
Peace Mabeta
Genetic lesions in proto-oncogenes result in the perturbation of angiogenesis, the formation of neovessels from a pre-existing microvasculature. Similarly, the subversion of tumor suppressor genes promotes tumor vascularization. Excessive neovessel formation is associated with various neoplasms such as infantile hemangiomas (IH). Hemangiomas are the most common tumors in pediatric patients and at present have no definitive treatment. The pathogenesis of IH is not well understood; however, both vasculogenesis and angiogenesis are associated with hemangioma genesis...
April 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29650696/npy-induces-stress-resilience-via-down-regulation-of-i-h-in-principal-neurons-of-rat-basolateral-amygdala
#11
Heika Silveira Villarroel, Maria Bompolaki, James Mackay, Ana Pamela Miranda Tapia, Sheldon D Michaelson, Randy J Leitermann, Robert A Marr, Janice H Urban, William F Colmers
Neuropeptide Y (NPY) expression is tightly linked with the development of stress resilience in rodents and humans. Local NPY injections targeting the basolateral amygdala (BLA) produce long-term behavioral stress resilience in male rats via an unknown mechanism. Previously, we showed that activation of NPY Y1 receptors hyperpolarizes BLA principal neurons (PNs) through inhibition of the hyperpolarization-activated, depolarizing H-current, Ih The present studies tested whether NPY treatment induces stress resilience by modulating Ih NPY (10 pmol) was delivered daily for 5 days bilaterally into the BLA to induce resilience; thereafter the electrophysiological properties of PNs and the expression of Ih in the BLA were characterized...
April 12, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29648555/thermal-conductivity-of-ice-polymorphs-a-computational-study
#12
Irene Iriarte-Carretero, Miguel A Gonzalez, Fernando Bresme
Thermal transport in ice features an unusual response. In addition to its intrinsic scientific interest, an understanding of the mechanisms determining the thermal conductivity of ice might be relevant in climate modelling and planetary science. Accurate microscopic models can provide important molecular insight into these mechanisms. In this work, we quantify using molecular simulations and state of the art forcefields, the thermal conductivity of ice Ih, VI, VII and a plastic phase that has been proposed very recently at pressures in the GPa range...
April 12, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29648496/the-wisdom-of-thai-indigenous-healers-for-the-spiritual-healing-of-fractures
#13
Siriratana Juntaramano, Janerawee Swangareeruk, Tanida Khunboonchan
AIMS: The aim of this study was to explore the wisdom of Thai indigenous healers (IHs) for physical and spiritual healing and their treatment process for fractures. METHOD: Twelve IHs from four regions of Thailand were selected using cluster and purposive sampling. They were interviewed on their methods for treating fractures. The Colaizzi method was used for analysis, and we returned to the IHs for validity confirmation. FINDINGS: The wisdom of IHs is believed to be inherited from ancestors and from a "sixth sense," their former teacher's spirit...
April 1, 2018: Journal of Holistic Nursing: Official Journal of the American Holistic Nurses' Association
https://www.readbyqxmd.com/read/29642407/load-bearing-capacity-and-retention-of-newly-developed-micro-locking-implant-prosthetic-system-an-in-vitro-pilot-study
#14
Jae-Won Choi, Kyung-Hee Choi, Hee-Jin Chae, Sung-Ki Chae, Eun-Bin Bae, Jin-Ju Lee, So-Hyoun Lee, Chang-Mo Jeong, Jung-Bo Huh
The aim of this study was to introduce the newly developed micro-locking implant prosthetic system and to evaluate the resulting its characteristics. To evaluate load-bearing capacity, 25 implants were divided into five groups: external-hexagon connection (EH), internal-octagon connection (IO), internal-hexagon connection (IH), one-body implant (OB), micro-locking implant system (ML). The maximum compressive load was measured using a universal testing machine (UTM) according to the ISO 14801. Retention was evaluated in two experiments: (1) a tensile test of the structure modifications of the components (attachment and implant) and (2) a tensile test after cyclic loading (total 5,000,000 cycles, 100 N, 2 Hz)...
April 6, 2018: Materials
https://www.readbyqxmd.com/read/29628207/inguinal-hernia-in-preterms-in-neonatal-intensive-care-units-optimal-timing-of-herniorrhaphy-and-necessity-of-contralateral-exploration-in-unilateral-presentation
#15
Joong Kee Youn, Hyun-Young Kim, Yeon-Ju Huh, Ji-Won Han, Soo-Hong Kim, Chaeyoun Oh, Ah Hae Jo, Kwi-Won Park, Sung-Eun Jung
BACKGROUND: We sought to determine the optimal timing of IH repair in preterms and the need for routine contralateral exploration. METHODS: Medical records of 3690 pediatric patients who underwent unilateral IH repair between January 1998 and December 2009 were reviewed. We assessed medical record review and telephone interviews. In total, 1990 patients were enrolled in the study. Early, early-delayed, and late repair were defined as herniorrhaphy performed within 7 days of diagnosis, later than 7 days of diagnosis, and after discharge from the NICU, respectively...
February 24, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29622890/incidental-discovery-of-anti-ih-in-a-patient-planned-for-caesarean-section-and-it-s-repercussions
#16
Lin-Nan Shao, Wen-Qian Song, Ni Wang, Wei-Jian Yu, Shi-Hang Zhou
No abstract text is available yet for this article.
April 2018: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29621088/treatment-of-facial-infantile-hemangioma-comparative-study-between-propranolol-and-ethanolamine-oleate
#17
Thais Miguel do Monte Lameiro, Rafael Denadai, João Carlos Pereira-Filho, Cesar Augusto Raposo-Amaral, Cassio Eduardo Raposo-Amaral
BACKGROUND: Infantile hemangiomas (IH) are the most common benign vascular tumors in childhood. Approximately 10% to 15% of these tumors require drug or surgical intervention. There are many options for IH treatment, of which propranolol is currently considered the gold standard. This study aims to compare the therapeutic results of 2 distinct drugs (ethanolamine oleate and propranolol), in order to increase the available therapeutic arsenal for the treatment of IH, thereby benefiting a larger group of patients...
April 4, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29620923/compatibility-of-amino-acids-in-ice-ih-implications-for-the-origin-of-life
#18
Jihua Hao, Elena Giovenco, Ulysse Pedreira-Segade, Gilles Montagnac, Isabelle Daniel
Icy environments may have been common on early Earth due to the faint young sun. Previous studies have proposed that the formation of large icy bodies in the early ocean could concentrate the building blocks of life in eutectic fluids and, therefore, facilitate the polymerization of monomers. This hypothesis is based on the untested assumption that organic molecules are virtually incompatible in ice Ih (hexagonal ice). In this study, we conducted freezing experiments to explore the partitioning behavior of selected amino acids (AAs; glycine, l-alanine, l-proline, and l-phenylalanine) between ice Ih and aqueous solutions analogous to seawater...
April 5, 2018: Astrobiology
https://www.readbyqxmd.com/read/29619755/high-frequency-of-computer-tomography-and-surgery-for-abdominal-pain-after-roux-en-y-gastric-bypass
#19
Jorunn Sandvik, Torstein Hole, Christian A Klöckner, Bård E Kulseng, Arne Wibe
INTRODUCTION: Acute, intermittent, and chronic abdominal pain is a common complaint after Roux-en-Y gastric bypass (RYGB). OBJECTIVES: The aim of the study was to evaluate the use of medical imaging and the need for surgery treating abdominal pain after RYGB in a cohort with long-term follow-up. METHODS: Data from 569 patients who underwent RYGB as the primary bariatric procedure at a public hospital in Norway between April 2004 and June 2011 were prospectively registered in a local quality registry for bariatric surgery...
April 4, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29617792/evaluating-intimal-hyperplasia-under-clinical-conditions
#20
Ioanna Mylonaki, Elisabeth Allain, Francesco Strano, Eric Allémann, Jean-Marc Corpataux, Paolo Meda, Olivier Jordan, Florence Delie, Anne-Laure Rougemont, Jacques-Antoine Haefliger, François Saucy
OBJECTIVES: Open arterial revascularization using venous segments is frequently associated with the development of intimal hyperplasia (IH), leading to severe restenosis and graft failure. The lack of treatment to prevent this pathology is a major problem. Therefore, we generated a new porcine model, which closely mimics the clinical development of human IH, to test the therapeutic potential of candidate drugs. METHODS: A patch of jugular vein was sutured to the right common carotid artery of pigs, to expose the vein to haemodynamic conditions of the arterial bed...
March 30, 2018: Interactive Cardiovascular and Thoracic Surgery
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