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Vitamine D3

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https://www.readbyqxmd.com/read/28931588/a-25-hydroxycholecalciferol-fortified-dairy-drink-is-more-effective-at-raising-a-marker-of-postprandial-vitamin-d-status-than-cholecalciferol-in-men-with-suboptimal-vitamin-d-status
#1
Jing Guo, Kim G Jackson, Che Suhaili Binti Che Taha, Yue Li, David I Givens, Julie A Lovegrove
Background: One strategy for improving population vitamin D status is consumption of fortified foods. However, the effects of dairy products fortified with different vitamin D isoforms on postprandial vitamin D status and metabolic outcomes have not been addressed.Objective: We investigated whether consumption of dairy drinks fortified with either 25-hydroxycholecalciferol [25(OH)D3] or cholecalciferol (vitamin D3) had differential effects on 24-h circulating plasma 25(OH)D3 concentration (a marker of vitamin D status) and cardiometabolic risk markers...
September 20, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28931466/1-alpha-25-dihydroxyvitamin-d3-up-regulates-the-expression-of-2-types-of-human-intestinal-alkaline-phosphatase-alternative-splicing-variants-in-caco-2-cells-and-may-be-an-important-regulator-of-their-expression-in-gut-homeostasis
#2
Seiko Noda, Asako Yamada, Kanae Nakaoka, Masae Goseki-Sone
Vitamin D insufficiency is associated with a greater risk of osteoporosis and also influences skeletal muscle functions, differentiation, and development. The principal function of vitamin D in calcium homeostasis is to increase the absorption of calcium from the intestine, and the level of alkaline phosphatase (ALP) activity, a differentiation marker for intestinal epithelial cells, is regulated by vitamin D. Intestinal-type ALP is expressed at a high concentration in the brush border membrane of intestinal epithelial cells, and is known to be affected by several kinds of nutrients...
August 4, 2017: Nutrition Research
https://www.readbyqxmd.com/read/28926322/vitamin-d-status-serum-lipid-concentrations-and-vitamin-d-receptor-vdr-gene-polymorphisms-in-familial-mediterranean-fever
#3
Turan Turhan, Halef Okan Doğan, Nihal Boğdaycioğlu, Nilnur Eyerci, Ahmet Omma, İsmail Sari, Ahmet Yeşilyurt, Yaşar Karaaslan
Vitamin D (VitD) is critical for the regulation of inflammatory processes, and VitD deficiency has been linked to several chronic inflammatory disorders. We aimed to investigate the concentrations of serum 25(OH)D3, lipid parameters, and three known VDR polymorphisms (BsmI, FokI, and TaqI) in patients with Familial Mediterranean fever (FMF), an autosomal recessive autoinflammatory disease. The study included 123 FMF patients and 105 controls. A total of 38 patients were in acute attacks at the time of investigation...
September 18, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28926129/evaluation-of-the-new-restandardized-abbott-architect-25-oh-vitamin-d-assay-in-vitamin-d-insufficient-and-vitamin-d-supplemented-individuals
#4
Wijtske Annema, Albina Nowak, Arnold von Eckardstein, Lanja Saleh
BACKGROUND: Recently, Abbott Diagnostics has restandardized the Architect 25(OH)D assay against the NIST SRM 2972. We have evaluated the analytical and clinical performance of the restandardized Architect 25(OH)D assay and compared its performance with a NIST-traceable liquid chromatography-tandem mass spectrometry (LC-MS/MS) method and the Roche total 25(OH)D assay in vitamin D-insufficient individuals before and after vitamin D3 supplementation. METHODS: Frozen serum samples were obtained from 88 healthy subjects with self-perceived fatigue and vitamin D-insufficiency <50 nmol L(-1) who were randomized to receive a single 100 000 IU dose of vitamin D3 (n = 48) or placebo (n = 40)...
September 19, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28924456/cutaneous-malignant-melanoma-incidences-analyzed-worldwide-by-sex-age-and-skin-type-over-personal-ultraviolet-b-dose-shows-no-role-for-sunburn-but-implies-one-for-vitamin-d3
#5
Dianne E Godar, Madhan Subramanian, Stephen J Merrill
Because the incidence of cutaneous malignant melanoma (CMM) was reported to increase with increasing terrestrial UVR (290-400 nm) doses in the US back in 1975 and a recent publication showed no association exists with UVR exposure at all, we set out to fully elucidate the role of UVR in CMM. To achieve this goal, we analyzed the CMM incidences over latitude and estimated the average personal UVR dose in the US and numerous countries (> 50) on 5 continents around the world. Using data from the International Agency for Research on Cancer in 2005, we performed worldwide analysis of CMM over UVR dose by sex, age group (0-14, 15-29, 30-49, 50-69, 70-85+) and Fitzpatrick skin types I-VI...
2017: Dermato-endocrinology
https://www.readbyqxmd.com/read/28922414/a-nonrandomized-trial-of-vitamin-d-supplementation-for-barrett-s-esophagus
#6
Linda C Cummings, Prashanthi N Thota, Joseph E Willis, Yanwen Chen, Gregory S Cooper, Nancy Furey, Beth Bednarchik, Bronia M Alashkar, John Dumot, Ashley L Faulx, Stephen P Fink, Adam M Kresak, Basel Abusneineh, Jill Barnholtz-Sloan, Patrick Leahy, Martina L Veigl, Amitabh Chak, Sanford D Markowitz
BACKGROUND: Vitamin D deficiency may increase esophageal cancer risk. Vitamin D affects genes regulating proliferation, apoptosis, and differentiation and induces the tumor suppressor 15-hydroxyprostaglandin dehydrogenase (PGDH) in other cancers. This nonrandomized interventional study assessed effects of vitamin D supplementation in Barrett's esophagus (BE). We hypothesized that vitamin D supplementation may have beneficial effects on gene expression including 15-PGDH in BE. METHODS: BE subjects with low grade or no dysplasia received vitamin D3 (cholecalciferol) 50,000 international units weekly plus a proton pump inhibitor for 12 weeks...
2017: PloS One
https://www.readbyqxmd.com/read/28921338/the-effect-of-high-dose-vitamin-d3-supplementation-on-bone-mineral-density-in-subjects-with-prediabetes
#7
A U Larsen, G Grimnes, R Jorde
The rationale of this study was to determine the effect of high-dose vitamin D3 supplementation on bone mineral density (BMD). Prediabetic males given vitamin D had significantly less reduction in BMD at the femoral neck compared to the controls. The clinical implications of our findings require further investigation. INTRODUCTION: Type 2 diabetes mellitus is associated with increased fracture risk, and recent studies show crosstalk between bone and glucose metabolism. Few studies have investigated the effect of vitamin D supplementation on the bone without additional calcium...
September 18, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28920809/evaluation-of-bone-mineralization-by-computed-tomography-in-wild-and-captive-european-common-spadefoots-pelobates-fuscus-in-relation-to-exposure-to-ultraviolet-b-radiation-and-dietary-supplements
#8
Martine van Zijll Langhout, Richard P J H Struijk, Tessa Könning, Dick van Zuilen, Katalin Horvath, Hester van Bolhuis, Roelof Maarschalkerweerd, Frank Verstappen
Captive rearing programs have been initiated to save the European common spadefoot (Pelobates fuscus), a toad species in the family of Pelobatidae, from extinction in The Netherlands. Evaluating whether this species needs ultraviolet B (UVB) radiation and/or dietary supplementation for healthy bone development is crucial for its captive management and related conservation efforts. The bone mineralization in the femurs and the thickest part of the parietal bone of the skulls of European common spadefoots (n = 51) was measured in Hounsfield units (HUs) by computed tomography...
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28920802/summer-and-winter-vitamin-d3-levels-in-seven-platyrrhine-species-housed-at-a-british-zoo-with-reference-to-natural-uvb-levels
#9
Rowena Killick, Richard Saunders, Sharon P Redrobe
Serum samples were collected from 24 platyrrhines of seven diurnal species housed with outdoor access at Bristol Zoo Gardens (United Kingdom) to test 25-hydroxyvitamin D3 (25OHD3) levels as part of the veterinary department's preventative health care program. Samples were collected in August 2008 (summer) and January 2009 (winter) to examine the effect of season on 25OHD3 levels. Dietary levels of vitamin D3 remained the same throughout the study period and fell within the range of 2000-4000 IU/kg dry matter, in accordance with current primate guidelines...
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28918929/vitamin-d-receptor-targeted-treatment-to-prevent-pathological-dedifferentiation-of-pancreatic-%C3%AE-cells-under-hyperglycaemic-stress
#10
A Neelankal John, Z Iqbal, S Colley, G Morahan, M Makishima, F-X Jiang
Dedifferentiation has been identified as one of the causes of β-cell failure resulting in type 2 diabetes (T2D). This study tested whether increasing vitamin D receptor (VDR) expression prevents dedifferentiation of β cells in a high-glucose state in vitro. Culturing a mouse insulinoma cell line (MIN6) in a high-glucose environment decreased VDR expression. However, increased VDR following vitamin D3 (VD3) treatment improved insulin release of early-passage MIN6 and insulin index of db/- (heterozygous) islets to levels seen in normal functional islets...
September 11, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28917261/development-of-standard-reference-material-srm-2973-vitamin-d-metabolites-in-frozen-human-serum-high-level
#11
Susan S-C Tai, Michael A Nelson, Mary Bedner, Brian E Lang, Karen W Phinney, Lane C Sander, James H Yen, Joseph M Betz, Christopher T Sempos, Stephen A Wise
The National Institute of Standards and Technology (NIST), in collaboration with the National Institutes of Health Office of Dietary Supplements and the Vitamin D Standardization Program, has recently issued a new serum-matrix Standard Reference Material (SRM): 2973 Vitamin D Metabolites in Frozen Human Serum (High Level). SRM 2973 was designed to provide a serum material with a total 25-hydroxyvitamin D [25(OH)D] concentration near 100 nmol/L to complement the existing serum-based SRMs with values assigned for total 25(OH)D between 20 and 80 nmol/L...
September 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28916992/longevity-of-daily-oral-vitamin-d3-supplementation-differences-in-25ohd-and-24-25-oh-2d-observed-2%C3%A2-years-after-cessation-of-a-1-year-randomised-controlled-trial-victory-recall
#12
H M Macdonald, A Gryka, J C Y Tang, L S Aucott, W D Fraser, A D Wood
To determine how long vitamin D lasts after supplementation ceases, the marker of status was measured 2 and 3 years after a 1-year trial. Compared to placebo, the proportion of vitamin D-deficient women was still lower, if they had taken daily vitamin D3, after 2 years, indicating its longevity. INTRODUCTION: The purpose of this study was to determine longevity of vitamin D status following cessation of vitamin D3 supplementation, 2 and 3 years after a 1-year randomised, double-blind placebo controlled trial and to investigate possible predictive factors...
September 15, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28915830/biological-effects-of-combined-resveratrol-and-vitamin-d3-on-ovarian-tissue
#13
Francesca Uberti, Vera Morsanuto, Silvio Aprile, Sabrina Ghirlanda, Ian Stoppa, Andrea Cochis, Giorgio Grosa, Lia Rimondini, Claudio Molinari
BACKGROUND: Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a natural antioxidant polyphenol able to exert a wide range of biological effect on several tissues. Despite its important beneficial properties, it has a low water solubility, which limits its therapeutic applications in humans. Resveratrol also acts as a phytoestrogen that modulates estrogen receptor (ER)-mediated transcription. In addition, it has been shown that ovarian tissues benefit greatly from vitamin D3, which exerts its beneficial effects through VDR receptors...
September 15, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28913556/high-dose-vitamin-d3-supplementation-decreases-the-number-of-colonic-cd103-dendritic-cells-in-healthy-subjects
#14
Nina Friis Bak, M Bendix, S Hald, L Reinert, M K Magnusson, J Agnholt
PURPOSE: Vitamin D may induce tolerance in the intestinal immune system and has been shown to regulate the phenotype of tolerogenic intestinal dendritic cells (DCs) in vitro. It is unknown whether vitamin D supplementation affects human intestinal DCs in vivo, and we aimed to investigate the tolerability and effect on intestinal CD103(+)DCs of high-dose vitamin D3 treatment in healthy subjects. METHODS: Ten healthy subjects received a total of 480,000 IU oral vitamin D3 over 15 days and colonic biopsies were obtained before and after intervention by endoscopy...
September 14, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28913006/uhplc-pda-assay-for-simultaneous-determination-of-vitamin-d3-and-menaquinone-7-in-pharmaceutical-solid-dosage-formulation
#15
Muhammad Jehangir, Mahmood Ahmed, Muhammad Imtiaz Shafiq, Abdul Samad, Iftikhar-Ul-Haq
A newly developed method based on ultrahigh performance liquid chromatography (UHPLC) was optimized for the simultaneous determination of vitamin D3 and menaquinone-7 (MK-7) in tablet formulation in the present study. UHPLC separation of vitamin D3 and MK-7 was performed with ACE Excel 2 C18-PFP column (2 μm, 2.1 × 100 mm) at 0.6 mL min(-1) flow rate, whereas the mobile phase consisted of methanol/water (19 : 1, v/v, phase A) and isopropyl alcohol (99.9%, phase B) containing 0.5% triethylamine. Isocratic separation of both the analytes was performed at 40°C by pumping the mobile phases A and B in the ratio of 50 : 50 (v/v, pH, 6...
2017: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/28912817/the-effects-of-vitamin-d-supplement-on-prevention-of-recurrence-of-preeclampsia-in-pregnant-women-with-a-history-of-preeclampsia
#16
Sanam Behjat Sasan, Farnaz Zandvakili, Nasrin Soufizadeh, Elaheh Baybordi
INTRODUCTION: Preeclampsia is a pregnancy-specific syndrome. One of the hypotheses concerning the etiology of preeclampsia is vitamin D deficiency during pregnancy. METHOD AND MATERIALS: The present study is a randomized controlled clinical trial which aims to determine the effect of vitamin D supplement on reducing the probability of recurrent preeclampsia. 72 patients were placed in control group while 70 patients were randomized to the intervention group. The intervention group received a 50000 IU pearl vitamin D3 once every two weeks...
2017: Obstetrics and Gynecology International
https://www.readbyqxmd.com/read/28912361/impact-of-sleep-restriction-on-local-immune-response-and-skin-barrier-restoration-with-and-without-multi-nutrient-nutrition-intervention
#17
Tracey J Smith, Marques A Wilson, J Philip Karl, Jeb Orr, Carl D Smith, Adam D Cooper, Kristin J Heaton, Andrew J Young, Scott J Montain
Systemic immune function is impaired by sleep restriction. However, the impact of sleep restriction on local immune responses, and to what extent any impairment can be mitigated by nutritional supplementation is unknown. We assessed the effect of 72-h sleep restriction (2-h nightly sleep) on local immune function and skin barrier restoration of an experimental wound, and determined the influence of habitual protein intake (1.5 g·kg(-1)·d(-1)) supplemented with arginine, glutamine, zinc sulfate, vitamin C, vitamin D3 and omega-3 fatty acids compared to lower protein intake (0...
September 14, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28906021/primary-hyperparathyroidism-dynamic-postoperative-metabolic-changes
#18
Reto Martin Kaderli, Philipp Riss, Angelika Geroldinger, Andreas Selberherr, Christian Scheuba, Bruno Niederle
OBJECTIVE: Little is known about the natural changes in parathyroid function after successful parathyroid surgery for primary hyperparathyroidism. The association of intact parathyroid hormone (iPTH) and calcium (Ca) with "temporary hypoparathyroidism" and "hungry bone syndrome" (HBS) was evaluated. DESIGN: Potential risk factors for temporary hypoparathyroidism and HBS were evaluated by taking blood samples before surgery, intraoperatively, at post-operative day (POD) 1, at POD 5 to 7, in postoperative week (POW) 8 and in postoperative month (POM) 6...
September 14, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28905271/pharmacokinetics-of-a-new-oral-vitamin-d-receptor-activator-2-methylene-19-nor-20s-1%C3%AE-25-dihydroxyvitamin-d3-in-patients-with-chronic-kidney-disease-and-secondary-hyperparathyroidism-on-hemodialysis
#19
Richa Pandey, Julia B Zella, Jinge G Zhu, Lori A Plum, Margaret Clagett-Dame, William J Blaser, Wendy Bedale, Hector F DeLuca, Daniel W Coyne
BACKGROUND: 2-Methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D3 (DP001 or 2MD) is a novel, potent 1α-hydroxylated vitamin D analog that binds to the vitamin D receptor and suppresses parathyroid hormone synthesis and secretion with potential for an improved safety profile compared to existing active vitamin D analogs. The purpose of this study was to evaluate the pharmacokinetics of DP001 given orally after hemodialysis. METHODS: DP001 (550 ng) was given orally to 11 hemodialysis patients with secondary hyperparathyroidism after each dialysis session (3 times/week) for 4 weeks...
September 13, 2017: Drugs in R&D
https://www.readbyqxmd.com/read/28904394/ultraviolet-b-light-emitting-diodes-leds-are-more-efficient-and-effective-in-producing-vitamin-d3-in-human-skin-compared-to-natural-sunlight
#20
T A Kalajian, A Aldoukhi, A J Veronikis, K Persons, M F Holick
Vitamin D, the sunshine vitamin is important for health. Those with fat malabsorption disorders malabsorb vitamin D and thus must rely on cutaneous production of vitamin D3. Vitamin D3 is generated secondary to exposure to ultraviolet B (UVB) radiation (whether from the sun or from an artificial source). Light emitting diodes (LEDs) have been developed to emit ultraviolet radiation. Little is known about the efficiency of UVB emitting LEDs tuned to different wavelengths for producing vitamin D3 in human skin...
September 13, 2017: Scientific Reports
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