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https://www.readbyqxmd.com/read/28230288/a-dual-label-time-resolved-fluorescence-immunoassay-for-the-simultaneous-determination-of-ferritin-and-%C3%AE-2-microglobulin
#1
Zhi Liu, Jing Huang, Rui-Ming Ou, Meng-Dong Yao, Yan-Lin She, Rui Chen, Cheng Li, Li Xu, Aikebaier Abudureyimu, Qing Zhang, Shuang Liu
BACKGROUND: Lymphocytic leukemia is a kind of primary malignant tumor of hematopoietic tissue. The aim was to establish a dual-label time-resolved fluorescence immunoassay (TRFIA) for the simultaneous determination of ferritin (FER) and β2 -microglobulin (β2 -MG) for the early screening and follow-up surveillance of lymphocytic leukemia. METHODS: The sandwich immunoassay was used to detect the concentration of FER, and the competitive immunoassay was used to detect the concentration of β2 -MG in serum...
February 23, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28229433/adalimumab-a-review-in-non-infectious-non-anterior-uveitis
#2
Sheridan M Hoy
Adalimumab (Humira(®)) is a tumour necrosis factor (TNF)-α inhibitor available in various countries worldwide, including the USA, Japan and those of the EU, for the treatment of non-infectious intermediate, posterior and panuveitis in adults. It is the first biological agent approved for this indication. In two multinational, phase III studies in adults with active and inactive disease, subcutaneous adalimumab significantly reduced the risk of treatment failure relative to placebo following the tapered withdrawal of corticosteroid therapy...
February 22, 2017: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/28229309/nusinersen-first-global-approval
#3
Sheridan M Hoy
Spinal muscular atrophy (SMA) is a rare autosomal recessive disorder characterized by muscle atrophy and weakness resulting from motor neuron degeneration in the spinal cord and brainstem. It is most commonly caused by insufficient levels of survival motor neuron (SMN) protein (which is critical for motor neuron maintenance) secondary to deletions or mutations in the SMN1 gene. Nusinersen (SPINRAZA™) is a modified antisense oligonucleotide that binds to a specific sequence in the intron, downstream of exon 7 on the pre-messenger ribonucleic acid (pre-mRNA) of the SMN2 gene...
February 22, 2017: Drugs
https://www.readbyqxmd.com/read/28229138/eawag-soil-in-envipath-a-new-resource-for-exploring-regulatory-pesticide-soil-biodegradation-pathways-and-half-life-data
#4
Diogo A R S Latino, Jörg Wicker, Martin Gütlein, Emanuel Schmid, Stefan Kramer, Kathrin Fenner
Developing models for the prediction of microbial biotransformation pathways and half-lives of trace organic contaminants in different environments requires as training data easily accessible and sufficiently large collections of respective biotransformation data that are annotated with metadata on study conditions. Here, we present the Eawag-Soil package, a public database that has been developed to contain all freely accessible regulatory data on pesticide degradation in laboratory soil simulation studies for pesticides registered in the EU (282 degradation pathways, 1535 reactions, 1619 compounds and 4716 biotransformation half-life values with corresponding metadata on study conditions)...
February 23, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28228133/is-there-enough-research-output-of-eu-projects-available-to-assess-and-improve-health-system-performance-an-attempt-to-understand-and-categorise-the-output-of-eu-projects-conducted-between-2002-and-2012
#5
Britta Zander, Reinhard Busse
BACKGROUND: Adequate performance assessment benefits from the use of disaggregated data to allow a proper evaluation of health systems. Since routinely collected data are usually not disaggregated enough to allow stratified analyses of healthcare needs, utilisation, cost and quality across different sectors, international research projects could fill this gap by exploring means to data collection or even providing individual-level data. The aim of this paper is therefore to (1) study the availability and accessibility of relevant European-funded health projects, and (2) to analyse their contents and methodologies...
February 22, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28227028/a-data-model-to-support-the-evaluation-of-coordinating-care-eu-programmes-in-the-context-of-the-act-programme
#6
P Natsiavas, D Filos, I Chouvarda, Ch Maramis, R van der Heijden, H Schonenberg, S Pauws, C Bescos, N Maglaveras, P Natsiavas, D Filos, I Chouvarda, C Maramis, R van der Heijden, H Schonenberg, S Pauws, C Bescos, N Maglaveras, R van der Heijden, P Natsiavas, S Pauws, Ch Maramis, C Bescos, D Filos, N Maglaveras, I Chouvarda, H Schonenberg
Advancing Care Coordination and Telehealth Deployment (ACT) is a European Union (EU) project, completed last October, which has developed a framework for evaluating and improving pioneering health care programs regarding coordinating care and telehealth (CC & TH) across specific EU regions. In this paper we present the key design decisions of the project's data model and the challenges faced. We focus on the definition of the multi-dimensional indicators in order to overcome data incompleteness and heterogeneity issues...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28224902/a-quartz-crystal-microbalance-sensor-for-endotoxin-assay-by-monitoring-limulus-amebocyte-lysate-protease-reaction
#7
Tao Liu, Wei Zhang, Lianqun Zhou, Zhen Guo, Yuguo Tang, Peng Miao
Endotoxin is able to trigger strong innate immune responses by interacting with specific receptors on immune cells. Therefore, accurate and rapid detection of endotoxin is of primary importance. In this study, endotoxin induced viscosity variation of limulus amebocyte lysate (LAL) reagent is monitored by a quartz crystal microbalance (QCM) sensor with enhanced signal. Based on the analysis of the relationship between endotoxin concentration and QCM frequency shift with time, an effective sensing strategy is developed for endotoxin assay, which shows excellent sensitivity and specificity in the linear detection range from 0...
April 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28224699/comparison-of-four-criteria-for-potentially-inappropriate-medications-in-brazilian-community-dwelling-older-adults
#8
Priscila Horta Novaes, Danielle Teles da Cruz, Alessandra Lamas Granero Lucchetti, Isabel Cristina Gonçalves Leite, Giancarlo Lucchetti
AIM: To compare four potentially inappropriate medication (PIM) criteria from different regions of the world in terms of their characteristics, concordance, sensitivity, specificity and predictive values in a community-dwelling sample. METHODS: A cross-sectional, observational, epidemiological study was carried out by a door-to-door survey in a Brazilian city. The following PIM criteria were applied: Beers-2015, Screening Tool of Older People's Potentially Inappropriate Prescriptions (STOPP)-2015, The European Union (EU)(7)-PIM list and Taiwan criteria...
February 22, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28224615/global-trends-in-nasopharyngeal-cancer-mortality-since-1970-and-predictions-for-2020-focus-on-low-risk-areas
#9
Greta Carioli, Eva Negri, Daisuke Kawakita, Werner Garavello, Carlo La Vecchia, Matteo Malvezzi
Nasopharyngeal cancer (NPC) mortality shows great disparity between endemic high risk areas, where non-keratinizing carcinoma (NKC) histology is prevalent, and non-endemic low risk regions, where the keratinizing squamous cell carcinoma (KSCC) type is more frequent. We used the World Health Organization database to calculate NPC mortality trends from 1970 to 2014 in several countries worldwide. For the EU, the USA and Japan, we also predicted trends to 2020. In 2012 the highest age-standardized (world standard) rates were in Hong Kong (4...
February 22, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28224162/preferential-site-occupancy-of-eu-3-ions-in-strontium-hydroxyapatite-nanocrystalline-sr10-po4-6-oh-2-structural-and-spectroscopic-characterisation
#10
Katarzyna Zawisza, Rafal J Wiglusz
Strontium hydroxyapatite (Sr10(PO4)6(OH)2) nanopowders doped with Eu(3+) ions were synthesized via a microwave-stimulated hydrothermal method and were heat-treated in the temperature range of 450-650 °C for 3 h. The concentration of Eu(3+) ions was set in the range of 0.5-5 mol% to investigate the site occupancy preference. The structural and morphological properties of the obtained samples were determined via XRD (X-ray powder diffraction) and TEM (transmission electron microscopy) techniques, as well as IR (infrared) and Raman spectroscopy...
February 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28223286/royal-college-welcomes-government-s-commitment-to-eu-workers
#11
Abi Rimmer
No abstract text is available yet for this article.
February 21, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28223076/leaching-of-rare-earth-elements-from-fluorescent-powder-using-the-tea-fungus-kombucha
#12
Stefanie Hopfe, Katrin Flemming, Falk Lehmann, Robert Möckel, Sabine Kutschke, Katrin Pollmann
In most modern technologies such as flat screens, highly effective magnets and lasers, as well as luminescence phosphors, Rare Earth Elements (REE) are used. Unfortunately no environmentally friendly recycling process exists so far. In comparison to other elements the interaction of microorganisms with REE has been studied to a less extent. However, as REE are ubiquitously present in nature it can be assumed that microorganisms play an important role in the biogeochemistry of REE. This study investigates the potential of organic acid-producing microbes for extracting REE from industrial waste...
February 17, 2017: Waste Management
https://www.readbyqxmd.com/read/28222979/from-macro-to-microplastics-analysis-of-eu-regulation-along-the-life-cycle-of-plastic-bags
#13
REVIEW
Ida M Steensgaard, Kristian Syberg, Sinja Rist, Nanna B Hartmann, Alessio Boldrin, Steffen Foss Hansen
Plastic pollution and its environmental effects has received global attention the recent years. However, limited attention has so far been directed towards how plastics are regulated in a life cycle perspective and how regulatory gaps can be addressed in order to limit and prevent environmental exposure and hazards of macro- and microplastics. In this paper, we map European regulation taking outset in the life cycle perspective of plastic carrier bags: from plastic bag production to when it enters the environment...
February 17, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28222385/the-effects-of-autohydrolysis-pretreatment-on-the-structural-characteristics-adsorptive-and-catalytic-properties-of-the-activated-carbon-prepared-from-eucommia-ulmoides-oliver-based-on-a-biorefinery-process
#14
Ming-Qiang Zhu, Zhi-Wen Wang, Jia-Long Wen, Ling Qiu, Ya-Hong Zhu, Yin-Quan Su, Qin Wei, Run-Cang Sun
Eucommia ulmoides Oliver (EU) wood was consecutively treated by autohydrolysis pretreatment and chemical carbonization post-treatment based on a biorefinery process. Results showed that the optimal condition of the autohydrolysis pretreatment and carbonization process yielded 10.37kg xylooligosaccharides (XOS), 1.39kg degraded hemicellulosic products, 17.29kg other degraded products from hemicelluloses and 40.72kg activated carbon (SBET of 1534.06m(2)/g) from the 100kg raw materials. Simultaneously, 29.14kg gas products generated from the optimum integrated process was significantly lower than that from the direct carbonization process (68...
February 11, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28221957/ochratoxin-a-concentrations-in-a-variety-of-grain-based-and-non-grain-based-foods-on-the-canadian-retail-market-from-2009-to-2014
#15
Beata Kolakowski, Sarah M O'Rourke, Henri P Bietlot, Karl Kurz, Barbara Aweryn
The extent of ochratoxin A (OTA) contamination of domestically produced foods sold across Canada was determined from 2009 to 2014 with sampling and testing occurring each fiscal year. Cereal-based, fruit-based, and soy-based food samples (n = 6,857) were analyzed. Almost half of the samples (3,200; 47%) did not contain detectable concentrations of OTA. The remaining 3,657 samples contained OTA at 0.040 to 631 ng/g. Wheat, oats, milled products of other grains (such as rye and buckwheat), and to a lesser extent corn products and their derived foods were the most significant potential sources of OTA exposure for the Canadian population...
December 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28221213/validation-of-the-european-health-literacy-survey-questionnaire-in-women-with-breast-cancer
#16
Yi-Jing Huang, Gong-Hong Lin, Wen-Shian Lu, Ka-Wai Tam, Chiehfeng Chen, Wen-Hsuan Hou, Ching-Lin Hsieh
BACKGROUND: Health literacy enables effective communication, participation, and cooperation with clinicians of patients with breast cancer in healthcare processes. The European Health Literacy Survey Questionnaire (HLS-EU-Q) comprehensively assesses multiple conceptual domains of health literacy in a diverse range of health contexts. However, the HLS-EU-Q has not been validated in women with breast cancer. OBJECTIVES: We examined the psychometric properties, particularly the factorial validity, of the HLS-EU-Q in women with breast cancer...
February 17, 2017: Cancer Nursing
https://www.readbyqxmd.com/read/28220809/multicolor-light-emitting-devices-with-tb2o3-on-silicon
#17
Ling Li, Shenwei Wang, Guangyao Mu, Xue Yin, Lixin Yi
Great efforts have been devoted to achieving efficient Si-based light-emitting devices. Here we report new light-emitting devices fabricated with Tb2O3 on Si substrates. Intense green electroluminescence was observed, with a turn-on voltage of about 8 V. The green emission is attributed to the characteristic transitions of Tb(3+) ions in Tb2O3. The electroluminescence mechanisms of the Tb2O3 light-emitting devices are discussed. In addition, visible and near infrared electroluminescence was observed in rare-earth (Eu(3+), Sm(3+) and Yb(3+)) doped Tb2O3 light-emitting devices...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220762/drug-detection-in-breath-non-invasive-assessment-of-illicit-or-pharmaceutical-drugs
#18
Phillip Trefz, Svend Kamysek, Patricia Fuchs, Pritam Sukul, Jochen Schubert, Wolfram Miekisch
Breath analysis not only holds great potential for the development of new non-invasive diagnostic methods, but also for the identification and follow up of drug levels in breath. This is of interest for both, forensic and medical science. On the one hand, the detection of drugs of abuse in exhaled breath - similar to the well-known breath alcohol tests - would be highly desirable as an alternative to blood or urine analysis in situations such as police controls for drugged driving. The noninvasive detection of drugs and their metabolites is thus of great interest in forensic science, especially since marijuana is becoming legalized in certain parts of the U...
February 21, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28220661/tunable-luminescence-and-energy-transfer-in-ca3-sio4-cl2-ce-3-li-mn-2-eu-2-phosphors
#19
Xiangqi Li, Xiuzhen Xie, Haiting Wei, Minzhen Zhong
A series of color-tunable Ca3-2x-y-z SiO4 Cl2 (CSC):xCe(3+) ,xLi(+) ,yMn(2+) ,zEu(2+) phosphors with low temperature phase structure was synthesized via the sol-gel method. An energy transfer process from Ce(3+) to Mn(2+) in CSC:0.01Ce(3+) ,0.01Li(+) ,yMn(2+) (y = 0.03-0.09) and the mechanism was verified to be an electric dipole-dipole interaction. The Ce(3+) and Mn(2+) emission intensities were greatly enhanced by co-doping Eu(2+) ions into CSC:0.01Ce(3+) ,0.01Li(+) ,0.07Mn(2+) phosphors due to competitive energy transfers from Eu(2+) /Ce(3+) to Mn(2+) , and Ce(3+) to Eu(2+) ...
February 21, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28220634/insights-into-the-discrepant-luminescence-for-basio3-eu-2-phosphors-prepared-by-solid-state-reaction-and-precipitation-reaction-methods
#20
Jiao Xu, Yang Zhao, Jingjing Chen, Zhiyong Mao, Yanfang Yang, Dajian Wang
Two synthesis routes, solid-state reaction and precipitation reaction, were employed to prepare BaSiO3 :Eu(2+) phosphors in this study. Discrepancies in the luminescence green emission at 505 nm for the solid-state reaction method sample and in the yellow emission at 570 nm for the sample prepared by the precipitation reaction method, were observed respectively. A detail investigation about the discrepant luminescence of BaSiO3 :Eu(2+) phosphors was performed by evaluation of X-ray diffraction (XRD), photoluminescence (PL)/photoluminescence excitation (PLE), decay time and thermal quenching properties...
February 21, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
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