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https://www.readbyqxmd.com/read/29331892/dynamic-probabilistic-material-flow-analysis-of-nano-sio2-nano-iron-oxides-nano-ceo2-nano-al2o3-and-quantum-dots-in-seven-european-regions
#1
Yan Wang, Bernd Nowack
Static environmental exposure assessment models based on material flow analysis (MFA) have previously been used to estimate flows of engineered nanomaterials (ENMs) to the environment. However, such models do not account for changes in the system behavior over time. Dynamic MFA used in this study includes the time-dependent development of the modelling system by considering accumulation of ENMs in stocks and the environment, and the dynamic release of ENMs from nano-products. In addition, this study also included regional variations in population, waste management systems, and environmental compartments, which subsequently influence the environmental release and concentrations of ENMs...
January 11, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29331635/sotatercept-with-long-term-extension-for-the-treatment-of-anaemia-in-patients-with-lower-risk-myelodysplastic-syndromes-a-phase-2-dose-ranging-trial
#2
Rami Komrokji, Guillermo Garcia-Manero, Lionel Ades, Thomas Prebet, David P Steensma, Joseph G Jurcic, Mikkael A Sekeres, Jesus Berdeja, Michael R Savona, Odile Beyne-Rauzy, Aspasia Stamatoullas, Amy E DeZern, Jacques Delaunay, Gautam Borthakur, Robert Rifkin, Thomas E Boyd, Abderrhamane Laadem, Bond Vo, Jennie Zhang, Marie Puccio-Pick, Kenneth M Attie, Pierre Fenaux, Alan F List
BACKGROUND: Myelodysplastic syndromes are characterised by ineffective erythropoiesis leading to anaemia. Sotatercept (ACE-011) is a novel activin receptor type IIA fusion protein that acts as a ligand trap to neutralise negative regulators of late-stage erythropoiesis. The aim of the study was to establish a safe and effective dose of sotatercept for the treatment of anaemia in patients with lower-risk myelodysplastic syndromes. METHODS: This open-label, multicentre, dose-ranging, phase 2 trial took place at 11 treatment centres in the USA and France...
January 10, 2018: Lancet Haematology
https://www.readbyqxmd.com/read/29330544/perceptions-of-legislation-relating-to-the-sharing-of-genomic-biobank-results-with-donors-a-survey-of-bbmri-eric-biobanks
#3
Minna Brunfeldt, Harriet Teare, Sirpa Soini, Helena Kääriäinen
Biobanks accumulate huge amounts of research findings, including participants' genomic data. Increasingly this leads to biobanks receiving research results that could be of clinical significance to biobank participants. The EU Horizon 2020 Project 'Genetics Clinic of the Future' surveyed European biobanks' perceptions of the legal and regulatory requirements for communicating individual research results to donors. The goal was to gain background knowledge for possible future guidelines, especially relating to the consent process...
January 12, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29330381/paper-based-inkjet-bioprinting-to-detect-fluorescence-resonance-energy-transfer-for-the-assessment-of-anti-inflammatory-activity
#4
Annie Agnes Suganya Samson, Jungmi Lee, Joon Myong Song
For the first time, a paper-based fluorescence resonance energy transfer (FRET) determination with cyclic AMP (cAMP)-specific phosphodiesterase 4B (PDE4B) inhibitory assay using an inkjet-printing technique is proposed. Non-fabricated parchment paper is found to constitute a unique substrate to measure fluorescent energy transfer, due to its insignificant self-absorption, and enables efficient sample interaction. Here, we report the responsive FRET signals generated on paper, upon sequentially printing reaction components on parchment paper using a conventional inkjet printer equipped with four cartridges...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329992/eus-elastography-strain-ratio-and-fractal-based-quantitative-analysis-for-the-diagnosis-of-solid-pancreatic-lesions
#5
Silvia Carrara, Milena Di Leo, Fabio Grizzi, Loredana Correale, Rahal Daoud, Andrea Anderloni, Francesco Auriemma, Alessandro Fugazza, Paoletta Preatoni, Roberta Maselli, Cesare Hassan, Elena Finati, Benedetto Mangiavillano, Alessandro Repici
BACKGROUND AND AIMS: EUS elastography is useful in characterizing solid pancreatic lesions (SPLs), and fractal analysis-based technology has been used to evaluate geometric complexity in oncology. The aim of this study was to evaluate EUS elastography (strain ratio) and fractal analysis for the characterization of SPLs. METHODS: Consecutive patients with SPLs were prospectively enrolled between December 2015 and February 2017. Elastographic evaluation included parenchymal strain ratio (pSR) and wall strain ratio (wSR) and was performed with the EU-ME2 processor (Olympus)...
January 9, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29329624/apparent-prevalence-of-and-risk-factors-for-infection-with-ostertagia-ostertagi-fasciola-hepatica-and-dictyocaulus-viviparus-in-swiss-dairy-herds
#6
C F Frey, R Eicher, K Raue, C Strube, M Bodmer, B Hentrich, B Gottstein, N Marreros
Infections with helminth parasites can negatively affect performance of dairy cows. Knowledge on infection intensity, spatial distributions and risk factors are key to develop targeted treatment strategies. Canada and most EU countries have conducted large investigations, but respective data for Switzerland were missing. We now performed a bulk tank milk serosurvey for Ostertagia ostertagi, Fasciola hepatica, and Dictyocaulus viviparus on a total of 1036 voluntarily participating dairy herds that were sampled at confinement periods, i...
January 30, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29325525/estimating-the-scale-of-chronic-hepatitis-b-virus-infection-among-migrants-in-eu-eea-countries
#7
Amena A Ahmad, Abby M Falla, Erika Duffell, Teymur Noori, Angela Bechini, Ralf Reintjes, Irene K Veldhuijzen
No abstract text is available yet for this article.
January 11, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29325508/mesh-nebulizers-have-become-the-first-choice-for-new-nebulized-pharmaceutical-drug-developments
#8
John N Pritchard, Ross Hm Hatley, John Denyer, Dirk von Hollen
In the 24 years since first being marketed, the mesh nebulizer has been developed by five main manufacturers into a viable solution for the delivery of high-value nebulized drugs. Mesh nebulizers provide increased portability, convenience and energy efficiency along with similar lung deposition and increased ease of use compared with jet nebulizers. An analysis of EU and US clinical trial databases has shown that mesh nebulizers are now preferred over jet nebulizers for clinical trials sponsored by pharmaceutical companies...
February 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/29324744/qcloud-a-cloud-based-quality-control-system-for-mass-spectrometry-based-proteomics-laboratories
#9
Cristina Chiva, Roger Olivella, Eva Borràs, Guadalupe Espadas, Olga Pastor, Amanda Solé, Eduard Sabidó
The increasing number of biomedical and translational applications in mass spectrometry-based proteomics poses new analytical challenges and raises the need for automated quality control systems. Despite previous efforts to set standard file formats, data processing workflows and key evaluation parameters for quality control, automated quality control systems are not yet widespread among proteomics laboratories, which limits the acquisition of high-quality results, inter-laboratory comparisons and the assessment of variability of instrumental platforms...
2018: PloS One
https://www.readbyqxmd.com/read/29324435/intermediate-valence-state-of-the-sm-and-eu-in-smb6-and-eucu2si2-neutron-spectroscopy-data-and-analysis
#10
P S Savchenkov, P A Alekseev, A Podlesnyak, A I Kolesnikov, K S Nemkovski
Magnetic neutron scattering data for Sm (SmB6, Sm(Y)S) and Eu (EuCu2Si2-x Ge x ) intermediate-valence compounds have been analysed in terms of a generalized model of the intermediate-radius exciton. Special attention is paid to the correlation between the average ion's valence and parameters of the low-energy excitation in the neutron spectra, such as the resonance mode, including its magnetic form factor. Along with specific features of the formation of the intermediate-valence state for Sm and Eu ions, common physical mechanisms have been revealed for systems based on these elements from the middle of the rare-earth series...
January 11, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29324384/flame-retardants-in-uk-furniture-increase-smoke-toxicity-more-than-they-reduce-fire-growth-rate
#11
Sean T McKenna, Robert Birtles, Kathryn Dickens, Richard G Walker, Michael J Spearpoint, Anna A Stec, T Richard Hull
This paper uses fire statistics to show the importance of fire toxicity on fire deaths and injuries, and the importance of upholstered furniture and bedding on fatalities from unwanted fires. The aim was to compare the fire hazards (fire growth and smoke toxicity) using different upholstery materials. Four compositions of sofa-bed were compared: three meeting UK Furniture Flammability Regulations (FFR), and one using materials without flame retardants intended for the mainland European market. Two of the UK sofa-beds relied on chemical flame retardants to meet the FFR, the third used natural materials and a technical weave in order to pass the test...
December 5, 2017: Chemosphere
https://www.readbyqxmd.com/read/29324088/validation-of-a-rapid-lateral-flow-method-for-the-detection-of-cows-milk-in-water-buffalo-sheep-or-goat-milk
#12
Patricia Galan-Malo, Isabel Mendiara, Pedro Razquin, Luis Mata
For many years the adulteration of milk from sheep, goats or water buffalos with cows' milk has been a widespread practice due to the higher cost of milk from those other species. Because of this, great concern has been shown by many Protected Designation of Origin councils that have to assure the quality and genuineness of the cheese produced by their associates. Therefore, the whole production chain needs analytical tools that allow the control of potential adulteration. Rapid methods to be used in the field are scarce and have not been validated according to international guidelines...
January 11, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29324081/determination-of-endogenous-concentrations-of-nitrites-and-nitrates-in-different-types-of-cheese-in-the-united-states-method-development-and-validation-using-ion-chromatography
#13
Susan Genualdi, Nahyun Jeong, Lowri DeJager
Nitrites and nitrates can be present in dairy products from both endogenous and exogenous sources. In the European Union (EU), 150 mg kg-1 of nitrates are allowed to be added to the cheese milk during the manufacturing process. The CODEX General Standard for Food Additives (GSFA) has a maximum permitted level of 50 mg kg-1 residue in cheese, while in the United States (US) nitrates are un-approved for use as food additives in cheese. In order to be able to investigate imported cheeses for nitrates intentionally added as preservatives and the endogenous concentrations of nitrates and nitrites present in cheeses in the US marketplace, a method was developed and validated using ion chromatography with conductivity detection...
January 11, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29323681/the-structure-of-a-lanthanide-complex-at-an-extractant-water-interface-studied-using-heterodyne-detected-vibrational-sum-frequency-generation
#14
Ryoji Kusaka, Masayuki Watanabe
Solvent extraction plays an integral part in the separation and purification of metals. Because extractants generally used as complexing agents for metal extractions, such as di-(2-ethylhexyl)phosphoric acid (HDEHP) for lanthanide extractions, are amphiphilic, they come to an organic/water interface, and the interface plays a crucial role as the site of the formation of metal complexes and the subsequent transfer reaction to an organic phase. Despite the importance of the interface for metal solvent extractions, its molecular-level structure is unclear because of the experimental difficulties...
January 11, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29323378/from-ligand-exchange-to-reaction-intermediates-what-does-really-happen-during-the-synthesis-of-emissive-complexes
#15
P Polzin, I V Eliani, J Ströh, M Braun, N Ruser, N Heidenreich, P Rönfeldt, F Bertram, C Näther, S Wöhlbrandt, M Suta, H Terraschke
In situ monitoring of the formation of emissive complexes is essential to enable the development of rational synthesis protocols, to provide accurate control over the generation of structure-related properties (such as luminescence) and to facilitate the development of new compounds. In situ luminescence analysis of coordination sensors (ILACS) utilizes the sensitivity of the spectroscopic properties of lanthanide ions to their coordination environment to detect structural changes during crystallization processes...
January 11, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29323363/high-efficiency-x-ray-luminescence-in-eu3-activated-tungstate-nanoprobes-for-optical-imaging-through-energy-transfer-sensitization
#16
Tao Guo, Yan Lin, Wei-Jian Zhang, Jin-Sheng Hong, Ru-Hui Lin, Xiao-Ping Wu, Juan Li, Chun-Hua Lu, Huang-Hao Yang
X-ray luminescence optical imaging has been recognized as a powerful technique for medical diagnosis due to its deep penetration and low auto-fluorescence in tissues. However, the low luminescence efficiency of current X-ray luminescence nanoprobes remains a major hurdle for sensitive bioimaging in practical medical applications. Here we present a new kind of energy transfer-sensitized X-ray luminescence nanoprobe (PEG-NaGd(WO4)2:Eu) for highly effective optical bioimaging. Under X-ray excitation, the tungstate host absorbs the X-ray photons and then transfers the energy to the Eu3+ luminescence center, thus enhancing the luminescence efficiency of the nanoprobes for high sensitivity optical in vivo imaging...
January 11, 2018: Nanoscale
https://www.readbyqxmd.com/read/29322568/energy-transfer-in-supramolecular-heteronuclear-lanthanide-dimers-and-application-to-fluoride-sensing-in-water
#17
Loic Charbonnière, Aline Nonat, Tao Liu, Franck Camerel, Olivier Jeannin
In the presence of fluoride anions, the [LnL(H2O)]+ complexes, based on the coordination of a lanthanide (Ln) cation into the cavity of a C2v symmetrical cyclen based ligand L, self-assemble in water to form [(LnL)2F]+ dimers. The crystal structures of the Yb hydrated monomer and of the fluorinated dimer are reported and analyzed to unravel the impact of the cumulative effect of weak hydrogen bonding and aromatic stacking interactions in the supramolecular assembly. The assembly is stable over a broad range of pH (3 to 8)...
January 11, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29322530/chromium-iii-release-from-chromium-tanned-leather-elicits-allergic-contact-dermatitis-a-use-test-study
#18
Yolanda S Hedberg, Behnaz Erfani, Mihály Matura, Carola Lidén
BACKGROUND: Chromium (Cr) is a common skin sensitizer. The use of Cr(VI) in leather is restricted in the EU, but that of Cr(III) is not. OBJECTIVES: To assess whether prolonged exposure to Cr-tanned leather with mainly Cr(III) release may elicit allergic contact dermatitis in Cr-allergic individuals. METHOD: Ten Cr-allergic subjects and 22 controls were patch tested with serial dilutions of Cr(III) and Cr(VI), and with leather samples. They then conducted a use test with a Cr-tanned and a Cr-free leather bracelet over a period of 3 weeks, for 12 h per day...
January 11, 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29321859/habitat-related-seed-germination-traits-in-alpine-habitats
#19
Maria Tudela-Isanta, Eduardo Fernández-Pascual, Malaka Wijayasinghe, Simone Orsenigo, Graziano Rossi, Hugh W Pritchard, Andrea Mondoni
Understanding the key aspects of plant regeneration from seeds is crucial in assessing species assembly to their habitats. However, the regenerative traits of seed dormancy and germination are underrepresented in this context. In the alpine zone, the large species and microhabitat diversity provide an ideal context to assess habitat-related regenerative strategies. To this end, seeds of 53 species growing in alpine siliceous and calcareous habitats (6230 and 6170 of EU Directive 92/43, respectively) were exposed to different temperature treatments under controlled laboratory conditions...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29321628/realizing-mitigation-efficiency-of-european-commercial-forests-by-climate-smart-forestry
#20
Rasoul Yousefpour, Andrey Lessa Derci Augustynczik, Christopher P O Reyer, Petra Lasch-Born, Felicitas Suckow, Marc Hanewinkel
European temperate and boreal forests sequester up to 12% of Europe's annual carbon emissions. Forest carbon density can be manipulated through management to maximize its climate mitigation potential, and fast-growing tree species may contribute the most to Climate Smart Forestry (CSF) compared to slow-growing hardwoods. This type of CSF takes into account not only forest resource potentials in sequestering carbon, but also the economic impact of regional forest products and discounts both variables over time...
January 10, 2018: Scientific Reports
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