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Anton Werwein, Florian Maaß, Leonhard Y Dorsch, Oliver Janka, Rainer Pöttgen, Thomas C Hansen, Justin Kimpton, Holger Kohlmann
The hydrogenation properties of Laves phases LnMg2 (Ln = La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Ho, Er, Tm, Yb) were investigated by thermal analysis, X-ray, synchrotron, and neutron powder diffraction. At 14.0 MPa hydrogen gas pressure and 393 K, PrMg2 and NdMg2 take up hydrogen and form the colorless, ternary hydrides PrMg2H7 (P41212, a = 632.386(6) pm, c = 945.722(11) pm) and NdMg2H7 (P41212, a = 630.354(9) pm, c = 943.018(16) pm). The crystal structures were refined by the Rietveld method from neutron powder diffraction data on the deuterides (PrMg2D7, P41212, a = 630...
November 22, 2017: Inorganic Chemistry
Matthew S Kelly, Jiayin Zheng, Sefelani Boiditswe, Andrew P Steenhoff, Kristen A Feemster, Tonya Arscott-Mills, Boitshepe Seme, Bakgaki Ratshaa, Ikanyeng Rulaganyang, Mohamed Z Patel, Savarra Mantzor, Samir S Shah, Coleen K Cunningham
Background: Human immunodeficiency virus-exposed but uninfected (HIV-EU) children have a higher mortality rate than the children of HIV-negative mothers (HIV-unexposed). Causal mediators of the poor health outcomes of HIV-EU children remain poorly defined. Methods: We conducted a hospital-based prospective cohort study of children aged 1 to 23 months with clinically defined pneumonia. The children were recruited at a referral hospital in Gaborone, Botswana, between April 2012 and June 2016...
November 20, 2017: Journal of the Pediatric Infectious Diseases Society
L R A Lepelaars, F Renda, L Pani, G Pimpinella, H G M Leufkens, G Trifirò, G Tafuri, A K Mantel-Teeuwisse, F Trotta
BACKGROUND: Biosimilars have been available in the European Union since 2006. However, their uptake in routine care is heterogeneous across countries. AIMS: To compare the safety information of biosimilars and their originators based on the information in the EU risk management plan (RMP). METHODS: A cross-sectional analysis on publicly available regulatory documents (RMPs and Summaries of Product Characteristics) of biosimilars and corresponding originators until 1 November 2015 was performed...
November 22, 2017: British Journal of Clinical Pharmacology
Maximilian Berthold, Ulf Karsten, Mario von Weber, Alexander Bachor, Rhena Schumann
The EU-water framework directive aims at nutrient reductions, since anthropogenically induced eutrophication is a major threat for coastal waters. However, phytoplankton biomass in southern Baltic Sea coastal water bodies (CWB) remains high and the underlying mechanisms are not well understood. Therefore, a CWB data set was analysed regarding changes in phytoplankton biomass and nutrient concentration of nitrogen (N) and phosphorus (P) from 2000 to 2014. It was expected to find imbalances between produced phytoplankton biomass and total nutrient concentrations...
November 21, 2017: Ambio
Elisa Kaltenbach, Eva Härdtner, Katharin Hermenau, Maggie Schauer, Thomas Elbert
Background: A substantial number of refugees present with mental disorders. This appears particularly acute in the currently increasing refugee populations in Europe. Although EU guidelines demand the identification and support of vulnerable individuals such as survivors of trauma, no adequately validated and comprehensive mental health screening instruments for refugees residing in Europe currently exist. Objective: We studied the feasibility, validity, and reliability of the Refugee Health Screener-15 (RHS-15) - a time-efficient and easy-to-implement screening developed by Hollifield et al...
2017: European Journal of Psychotraumatology
Azizah M Afif, Jason Pik-Eu Chang, Yan Y Wang, Simin D Lau, Fuzhen Deng, Shy Y Goh, Mar K Pwint, Chin C Ooi, Nanda Venkatanarasimha, Richard Hg Lo
Objective: Liver cirrhosis has been a rising complication of chronic liver disease in Singapore. Ultrasound has been widely accepted as a non-invasive imaging modality for the evaluation of hepatic haemodynamics. This study aims to correlate the Doppler ultrasound values with the progression of liver cirrhosis to allow further understanding and possible prediction of clinical events for timely intervention. Methods: Study sample of 56 eligible patients with liver cirrhosis was divided according to their Child-Pugh clinical score into Child's A (n = 29 patients), B (n = 19 patients) and C (n = 8 patients)...
November 2017: Ultrasound: Journal of the British Medical Ultrasound Society
Yue Guo, Sung Heum Park, Byung Chun Choi, Jung Hyun Jeong, Jung Hwan Kim
A Bi(3+) and Eu(3+) ion co-doped Ba9Lu2Si6O24 single-phased phosphor was synthesized successfully via a conventional high-temperature solid-state reaction. X-ray diffraction, crystal structure analysis, diffuse reflectance and luminescent spectra, quantum efficiency measurements, and thermal stability analysis were applied to investigate the phase, structure, luminescent and thermal stability properties. From the analyses of the crystal structure and luminescent spectra, we observed four discernible Bi(3+) luminescent centers with peaks at ~363...
November 21, 2017: Scientific Reports
Laurence Watier, Philippe Cavalié, Bruno Coignard, Christian Brun-Buisson
Defined daily doses (DDD) are the gold standard indicator for quantifying prescriptions. Since 2014, the European Centre for Disease Prevention and Control (ECDC) has also been using the number of packages per 1,000 inhabitants per day (ipd), as a surrogate for prescriptions, to report antibiotic consumption in the community and to perform comparisons between European Union (EU) countries participating in the European Surveillance of Antimicrobial Consumption Network (ESAC-Net). In 2015, consumption was reported to range across Europe from 1...
November 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
Varvara A Mouchtouri, Eleni Verykouki, Dumitru Zamfir, Christos Hadjipetris, Hannah C Lewis, Christos Hadjichristodoulou, The Eu Shipsan Act Partnership
When an increased number of acute gastroenteritis (AG) cases is detected among tourists staying at the same accommodation, outbreak management plans must be activated in a timely manner to prevent large outbreaks. Syndromic surveillance data collected between 1 January 2010 and 31 December 2013 by five seagoing cruise ships were analysed to identify attack rate thresholds for early outbreak detection. The overall incidence rate of AG was 2.81 cases per 10,000 traveller-days (95% confidence interval (CI): 0...
November 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
Heli Harvala, Aftab Jasir, Pasi Penttinen, Lucia Pastore Celentano, Donato Greco, Eeva Broberg
Enteroviruses (EVs) cause severe outbreaks of respiratory and neurological disease as illustrated by EV-D68 and EV-A71 outbreaks, respectively. We have mapped European laboratory capacity for identification and characterisation of non-polio EVs to improve preparedness to respond to (re)-emerging EVs linked to severe disease. An online questionnaire on non-polio EV surveillance and laboratory detection was submitted to all 30 European Union (EU)/European Economic Area (EEA) countries. Twenty-nine countries responded; 26 conducted laboratory-based non-polio EV surveillance, and 24 included neurological infections in their surveillance...
November 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
Xiuting Chen, Qingnuan Li, Yu Gong
Tripositive Ln(TMTDA)33+ complexes (Ln = La-Lu except Pm, TMTDA= tetramethyl 3-thio-diglycolamide) were observed in the gas phase by electrospray ionization (ESI) of LnCl3 and TMTDA mixtures. Collision induced dissociation (CID) was employed to investigate their fragmentation chemistry, which revealed the influence of metal center as well as ligand on the ligated complexes. Ln(TMTDA)2(TMTDA-45)3+ resulting from Ccarbonyl-N bond cleavage of TMTDA and hydrogen transfer was the major CID product for all Ln(TMTDA)33+ except Eu(TMTDA)33+ which predominantly formed charge reducing product EuII(TMTDA)22+ via electron transfer from TMTDA to Eu3+...
November 22, 2017: Journal of Physical Chemistry. A
Ronald de Hoogt, Marta F Estrada, Suzana Vidic, Emma J Davies, Annika Osswald, Michael Barbier, Vítor E Santo, Kjersti Gjerde, Hanneke J A A van Zoggel, Sami Blom, Meng Dong, Katja Närhi, Erwin Boghaert, Catarina Brito, Yolanda Chong, Wolfgang Sommergruber, Heiko van der Kuip, Wytske M van Weerden, Emmy W Verschuren, John Hickman, Ralph Graeser
Two-dimensional (2D) culture of cancer cells in vitro does not recapitulate the three-dimensional (3D) architecture, heterogeneity and complexity of human tumors. More representative models are required that better reflect key aspects of tumor biology. These are essential studies of cancer biology and immunology as well as for target validation and drug discovery. The Innovative Medicines Initiative (IMI) consortium PREDECT ( characterized in vitro models of three solid tumor types with the goal to capture elements of tumor complexity and heterogeneity...
November 21, 2017: Scientific Data
Clare Bradshaw, Lindis Skipperud, N Beresford, C L Barnett, Miquel Vidal
The 2014 Strategic Research Agenda (SRA) for Radioecology identified that the key challenge in education and training (E&T) was "to maintain and develop a skilled workforce in Europe and world-wide, through university candidates and professionals trained within radioecology" since "scientific research in radioecology and application of that knowledge… requires scientists and workers with adequate competence and appropriate skills." Radioecology is a multidisciplinary science and E&T is needed by both students and professionals within research, industry and radiation protection...
November 21, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
Jacqueline Garnier-Laplace, Hildegarde Vandenhove, N Beresford, Maarit Muikku, Almudena Real
The ALLIANCE Strategic Research Agenda (SRA) initiated by the STAR Network of Excellence and integrated in the research strategy implemented by the COMET consortium, defines a long-term vision of the needs for, and implementation of, research in radioecology. This reference document, reflecting views from many stakeholders groups and researchers, serves as an input to those responsible for defining EU research call topics through the ALLIANCE SRA statement delivered each year to the EJP CONCERT (2015-2020)...
November 21, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
Frederic Roca, Michele Iacob, Isabelle Remy-Jouet, Jeremy Bellien, Robinson Joannides
Arterial wall viscosity (AWV) is a major cause of energy dissipation along the arterial tree. Its determinants remain controversial but an active endothelial regulation has been suggested. Our objective was to assess in humans the physiological role of endothelium-derived nitric oxide (NO), epoxyeicosatrienoic acids and the effect of modulating smooth muscle tone in the regulation of AWV. We simultaneously measured radial artery diameter, wall thickness, and arterial pressure in healthy volunteers during the local infusion of inhibitors of NO-synthase (N(G)-monomethyl-l-arginine), epoxyeicosatrienoic acids synthesis by cytochrome P450 (fluconazole), the epoxyeicosatrienoic acids cellular targets calcium-activated potassium channels (tetraethylammonium), alone and in combination...
November 20, 2017: Hypertension
M A Pfaller, P R Rhomberg, M D Huband, R K Flamm
The activity of omadacycline and comparators when tested against a subset of Streptococcus pneumoniae from US and European regions of a 2014 global surveillance program (304 isolates) are reported. These MIC results were compared to those obtained when testing S. pneumoniae from 2010 surveillance (1,834 isolates). The omadacycline MIC50/90 for S. pneumoniae (2014) was 0.06/0.06μg/mL, similar to 2010 (MIC50/90, 0.06/0.12μg/mL). The omadacycline MIC90 (0.06-0.12μg/mL) was similar for the penicillin-susceptible, -intermediate, -resistant, multidrug-resistance (MDR; ≥3 classes), and ceftriaxone nonsusceptible subgroups...
October 19, 2017: Diagnostic Microbiology and Infectious Disease
Bo-Sen Wu, Mark G Lefsrud
Light emitting diodes have slowly gained market share as horticultural lighting systems in greenhouses due to their rapid improvement in color performances and light outputs. These advancements have increased the availability of the full spectrum of visible wavelengths and the corresponding irradiance outputs available to plants. However, light emitting diodes owners have limited information on the proper options for personal eyewear protection as the irradiance levels have increased. The objective of this study was to measure the light transmittance performance of 12 eyewear protection including welding goggles, safety goggles, polarized glasses and sunglasses across the human visible spectrum (380-740 nm) up to an irradiance level of 1500 W·m(-2) from high-irradiant light emitting diodes assemblies...
November 20, 2017: Journal of Occupational and Environmental Hygiene
Derek Stewart, Kathrine Gibson-Smith, Katie MacLure, Alpana Mair, Albert Alonso, Carles Codina, Antonio Cittadini, Fernando Fernandez-Llimos, Glenda Fleming, Dimitra Gennimata, Ulrika Gillespie, Cathy Harrison, Ulrike Junius-Walker, Przemysław Kardas, Thomas Kempen, Moira Kinnear, Pawel Lewek, Joao Malva, Jennifer McIntosh, Claire Scullin, Birgitt Wiese
BACKGROUND: Inappropriate use of multiple medicines (inappropriate polypharmacy) is a major challenge in older people with consequences of increased prevalence and severity of adverse drug reactions and interactions, and reduced medicines adherence. The aim of this study was to determine the levels of consensus amongst key stakeholders in the European Union (EU) in relation to aspects of the management of polypharmacy in older people. METHODS: Forty-six statements were developed on aspects of healthcare structures, processes and desired outcomes, with consensus defined at ≥ 80% agreement...
2017: PloS One
Giovanni Sotgiu, Dennis Falzon, Vahur Hollo, Csaba Ködmön, Nicolas Lefebvre, Andrei Dadu, Marieke van der Werf
BACKGROUND: We explored host-related factors associated with the site of tuberculosis (TB) disease using variables routinely collected by the 31 EU/EEA countries for national surveillance. METHODS: Logistic regression models were fitted to case-based surveillance data reported to the European Centre for Disease Prevention and Control for TB cases notified from 2003 to 2014. Missing data on HIV infection and on susceptibility to isoniazid and rifampicin for many patients precluded the inclusion of these variables in the analysis...
2017: PloS One
Andrew Forrest McWhan, Wioletta Dobrzynska
The reduction of the dose limit for eye lens from 150 to 20 mSv year-1 must be implemented by EU member states by February 2018. Consequently, there is a requirement for all employers engaged with work with ionising radiation to have appropriate monitoring arrangements in place by this date to demonstrate that they can meet this new limit for all workers. Eye lens dose is conventionally monitored by specific dosemeters worn near the eye. However, it is usually impractical for these dosemeters to be worn at all times in the workplace which can lead to problems accounting for any periods of work when an eye lens dosemeter has not been worn...
November 20, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
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