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https://www.readbyqxmd.com/read/28343202/european-experience-of-regulating-distance-selling-of-medicines-for-ukraine
#1
Vitalii Pashkov, Yevhen Hrekov, Maryna Hrekova
INTRODUCTION: Some countries have already tried and tested mechanisms of regulating distance sales as form of distribution of medicines that have been used more or less effectively for a fairly long time. Herewith, so far, the approach of the competent authorities of some countries including Ukraine can be called prevailing in quantitative terms under which the official prohibition on distance sales of medicines is set. AIM: The aim of this study is a detailed examination of the nature of the prohibition of the medicines distance selling in Ukraine, namely the an analysis of advantages and disadvantages of this form of distribution of medicines and identification of appropriate ways for gradual repeal of the prohibition in terms of regulatory reform in Ukraine in the sphere of circulation of medicines due to the process of adaptation of statutory regulation in this area to the EU legislation...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28339949/bone-biopsy-practice-patterns-across-europe-the-european-renal-osteodystrophy-initiative-a-position-paper
#2
Pieter Evenepoel, Patrick D'Haese, Justine Bacchetta, Jorge Cannata-Andia, Anibal Ferreira, Mathias Haarhaus, Sandro Mazzaferro, Marie-Helene Lafage Proust, Syazrah Salam, Goce Spasovski, Mario Cozzolino
Renal osteodystrophy (ROD) is a heterogeneous group of metabolic bone diseases complicating progressive chronic kidney disease (CKD). Bone biomarkers and bone imaging techniques may help to assess bone health and predict fractures in CKD but do have important inherent limitations. By informing on bone turnover and mineralization, a bone biopsy may help to guide prevention and treatment of ROD and its consequences. According to a recent survey conducted among European nephrologists, bone biopsies are performed rather exceptionally, both for clinical and research purposes...
March 3, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28339479/mouse-newborn-cells-allow-highly-productive-mouse-cytomegalovirus-replication-constituting-a-novel-convenient-primary-cell-culture-system
#3
Vu Thuy Khanh Le-Trilling, Mirko Trilling
Mammalian cell culture is indispensable for most aspects of current biomedical research. Immortalized cell lines are very convenient, but transforming principles (e.g. oncogenic viruses or their oncogenes) can heavily influence the experimental outcome. Primary cells do not share this apparent disadvantage but are more laborious to generate. Certain viruses (e.g. mouse cytomegalovirus) do not replicate efficiently in most transformed cell lines. In the past, such viruses have been routinely propagated on primary mouse embryonic fibroblasts (MEF) established around day 17 (d17) of gestation...
2017: PloS One
https://www.readbyqxmd.com/read/28338889/measuring-occupational-exposure-to-extremely-low-frequency-electric-fields-at-220-kv-substations
#4
Herkko Pirkkalainen, Timo Heiskanen, Juhani Tonteri, Jarmo Elovaara, Penttilä Mika, Leena Korpinen
Earlier studies conducted at 400 and 110 kV substations in Finland have shown that the occupational exposure to electric fields can exceed the action levels (ALs) set by Directive 2013/35/EU. This is a case study investigating the level of occupational exposure experienced by workers at 220 kV substations in order to determine if the actions levels are being exceeded. The measurements were conducted at two old 220 kV substations in Finland. The higher AL of 20 kV m-1 was exceeded at both substations.
March 3, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28338148/extraction-of-minor-actinides-lanthanides-and-other-fission-products-by-silica-immobilized-btbp-btphen-ligands
#5
Ashfaq Afsar, Petr Distler, Laurence M Harwood, Jan John, James Westwood
Novel BTBP [bis-(1,2,4-triazin-3-yl)-2,2'-bipyridine]/BTPhen [bis-(1,2,4-triazin-3-yl)-1,10-phenanthroline] functionalized silica gels have been developed to extract minor actinides, lanthanides and other fission products. BTPhen functionalized silica gel is capable of near-quantitative removal of Am(iii) in the presence of Eu(iii) from aqueous HNO3, while BTBP functionalized silica gel is able to remove problematic corrosion and fission products that are found in PUREX raffinates.
March 24, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28337510/-seven-years-of-the-national-action-league-for-people-with-rare-diseases-namse-a-success-story
#6
Alexandra Halbach, Birgit Schnieders, Karin Knufmann-Happe
It is estimated that four million people in Germany are living with a rare disease; in the EU, approximately 30 million people are affected. All rare diseases are chronic, linked to invalidity and/or restricted life expectancy, and their symptoms are often already manifest in childhood. Some 80% of rare diseases are genetically determined; they can rarely be cured. Furthermore, the pathogenesis of many rare diseases is unknown.In a move to ameliorate the situation of persons with rare diseases, the National Action League for People with Rare Diseases (NAMSE) published the National Plan of Action for People with Rare Diseases containing 52 measures that aim to achieve the desired improvements...
March 23, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28337118/toxicological-risk-at-workplace-and-toxicity-as-life-cycle-assessment-impact-category-substitution-of-solvents-as-an-example
#7
Thomas Schupp, Philipp Alexander Georg, Guenter Kirstein
Substitution of hazardous substances against less hazardous ones is a central requirement of the European Chemical Regulation REACH (European Regulation 1907/2006/EC). Hazardous substances emitted from products may not only affect the worker; drift off and distribution in the environment may finally result in exposure of the general population. This potential threat to health is covered by the impact category "toxicity" in Life Cycle Assessments. In this paper, we present a case of a substitution of volatile organic compounds in a reactive varnish, and compare the "old" formulation with the "new" formulation against health risk to the worker, and concerning the Life Cycle Assessment impact category "toxicity"...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28336868/eu-gd-codoped-yttria-nanoprobes-for-optical-and-t%C3%A2-weighted-magnetic-resonance-imaging
#8
Timur Sh Atabaev, Jong Ho Lee, Yong Cheol Shin, Dong-Wook Han, Ki Seok Choo, Ung Bae Jeon, Jae Yeon Hwang, Jeong A Yeom, Hyung-Kook Kim, Yoon-Hwae Hwang
Nanoprobes with multimodal functionality have attracted significant interest recently because of their potential applications in nanomedicine. This paper reports the successful development of lanthanide-doped Y₂O₃ nanoprobes for potential applications in optical and magnetic resonance (MR) imaging. The morphology, structural, and optical properties of these nanoprobes were characterized by transmission electron microscope (TEM), field emission scanning electron microscope (FESEM), X-ray diffraction (XRD), energy-dispersive X-ray (EDX), and photoluminescence (PL)...
February 10, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28336860/light-emission-intensities-of-luminescent-y%C3%A2-o%C3%A2-eu-and-gd%C3%A2-o%C3%A2-eu-particles-of-various-sizes
#9
Jens Adam, Wilhelm Metzger, Marcus Koch, Peter Rogin, Toon Coenen, Jennifer S Atchison, Peter König
There is great technological interest in elucidating the effect of particle size on the luminescence efficiency of doped rare earth oxides. This study demonstrates unambiguously that there is a size effect and that it is not dependent on the calcination temperature. The Y₂O₃:Eu and Gd₂O₃:Eu particles used in this study were synthesized using wet chemistry to produce particles ranging in size between 7 nm and 326 nm and a commercially available phosphor. These particles were characterized using three excitation methods: UV light at 250 nm wavelength, electron beam at 10 kV, and X-rays generated at 100 kV...
January 25, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28336466/global-trends-and-predictions-in-hepatocellular-carcinoma-mortality
#10
Paola Bertuccio, Federica Turati, Greta Carioli, Teresa Rodriguez, Carlo La Vecchia, Matteo Malvezzi, Eva Negri
BACKGROUND: Hepatocellular carcinoma (HCC) has been one of the few cancers showing upward trends over recent decades in most countries, and is the third cause of cancer death worldwide. PATIENTS AND METHODS: We updated global trends in HCC mortality to 2014, and predicted trends in rates in the EU, USA and Japan to 2020, using data from the World Health Organization database. RESULTS: In EU men, mortality rates were stable in the last decade around 3...
March 20, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28336423/comparative-analysis-of-complete-genome-sequences-of-european-subtype-tick-borne-encephalitis-virus-strains-isolated-from-ixodes-persulcatus-ticks-long-tailed-ground-squirrel-spermophilus-undulatus-and-human-blood-in-the-asian-part-of-russia
#11
T V Demina, S E Tkachev, I V Kozlova, E K Doroshchenko, O V Lisak, O V Suntsova, M M Verkhozina, Yu P Dzhioev, A I Paramonov, A Y Tikunov, N V Tikunova, V I Zlobin, D Ruzek
Tick-borne encephalitis virus (TBEV) is divided into three subtypes: European (TBEV-Eu), Siberian (TBEV-Sib), and Far Eastern (TBEV-FE) subtypes. The geographical range of TBEV-Eu dominates in Europe, but this subtype is present focally across the whole non-tropical forested Eurasian belt, through Russia to South Korea. However, the TBEV-Eu strains isolated outside Europe remain poorly characterized. In this study, full-genome sequences of eight TBEV-Eu isolates were determined. These strains were isolated from Ixodes persulcatus ticks, long-tailed ground squirrel (Spermophilus undulatus), and human blood in the natural foci of Western and Eastern Siberia, Russia...
March 9, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28336103/25-hydroxyvitamin-d-is-differentially-associated-with-calcium-intakes-of-northern-central-and-southern-european-adolescents-results-from-the-helena-study
#12
Cristina Julian, Marcela González-Gross, Christina Breidenassel, Theodora Mouratidou, Germán Vicente-Rodriguez, Luis Gracia-Marco, Marika Ferrari, Kurt Widhalm, Dénes Molnár, Anthony Kafatos, Frederic Gottrand, Yannis Manios, Alejandro de la O, Mathilde Kersting, Stefaan De Henauw, Marc J Gunter, Luis A Moreno, Inge Huybrechts
OBJECTIVES: Adolescents in the European Union (EU) exhibit a higher prevalence of vitamin D (VitD) deficiency than other age groups. The degree to which sunlight exposure 25-hydroxyvitamin D [25(OH)D] concentrations depends on a variety of factors, including diet. Nevertheless, the relationship between calcium and VitD intake and 25(OH)D concentrations has not been previously studied among adolescents living in different EU countries and consequently in different latitudes. Therefore, the aim of this study was to examine whether calcium and VitD intakes are differentially associated with 25(OH)D in adolescents from northern, central and southern EU countries...
April 2017: Nutrition
https://www.readbyqxmd.com/read/28335565/an-eco-safety-assessment-of-glyoxal-containing-cellulose-ether-on-freeze-dried-microbial-strain-cyanobacteria-daphnia-and-zebrafish
#13
Chang-Beom Park, Min Ju Song, Nak Woon Choi, Sunghoon Kim, Hyun Pyo Jeon, Sanghun Kim, Youngjun Kim
The objective of this study was to investigate the aquatic-toxic effects of glyoxal-containing cellulose ether with four different glyoxal concentrations (0%, 1.4%, 2.3%, and 6.3%) in response to global chemical regulations, e.g., European Union Classification, Labeling and Packaging (EU CLP). Toxicity tests of glyoxal-containing cellulose ether on 11 different microbial strains, Microcystis aeruginosa, Daphnia magna, and zebrafish embryos were designed as an initial stage of toxicity screening and performed in accordance with standardized toxicity test guidelines...
March 21, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28334772/transparency-policies-of-the-european-medicines-agency-has-the-paradigm-shifted
#14
Daria Kim
This article reflects on the state of play as regards access to non-summary clinical trial data in the European Union (EU). In particular, it examines the scope of access under the recent transparency policies of the European Medicines Agency (EMA) that attempt to break away from the presumptively confidential treatment of clinical trial data. In light of the emerging case law of the Court of Justice of the European Union on clinical trial data disclosure, it remains highly uncertain what data, and under what conditions, can be lawfully released by the EMA...
February 23, 2017: Medical Law Review
https://www.readbyqxmd.com/read/28333452/mixed-lanthanide-porous-coordination-polymers-showing-range-tunable-ratiometric-luminescence-for-o2-sensing
#15
Jia-Wen Ye, Jiao-Min Lin, Zong-Wen Mo, Chun-Ting He, Hao-Long Zhou, Jie-Peng Zhang, Xiao-Ming Chen
Luminescent porous coordination polymers (PCPs) are emerging as attractive oxygen-sensing materials, but they are mostly based on single-wavelength luminometry. Here, we report a special mixed-lanthanide strategy for self-referenced ratiometric oxygen sensing. A series of isostructural, pure-lanthanide, or mixed-lanthanide PCPs, MCF-53(Tb/Eux), were synthesized by solvothermal reactions. Single-crystal X-ray diffraction revealed that MCF-53(Tb/Eux) is composed of complicated two-dimensional coordination networks, which interdigitate to form a three-dimensional supramolecular structure retaining one-dimensional ultra-micropores...
March 23, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28332675/tailoring-the-structure-and-thermoelectric-properties-of-batio3via-eu-2-substitution
#16
Xingxing Xiao, Marc Widenmeyer, Wenjie Xie, Tianhua Zou, Songhak Yoon, Marco Scavini, Stefano Checchia, Zhicheng Zhong, Philipp Hansmann, Stefan Kilper, Andrei Kovalevsky, Anke Weidenkaff
A series of Ba1-xEuxTiO3-δ (0.1 ≤ x ≤ 0.9) phases with ∼40 nm particle size were synthesized via a Pechini method followed by annealing and sintering under a reducing atmosphere. The effects of Eu(2+) substitution on the BaTiO3 crystal structure and the thermoelectric transport properties were systematically investigated. According to synchrotron X-ray diffraction data only cubic perovskite structures were observed. On the local scale below about 20 Å (equal to ∼5 unit cells) deviations from the cubic structure model (Pm3[combining macron]m) were detected by evaluation of the pair distribution function (PDF)...
March 23, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28332344/impact-of-intervention-by-an-antimicrobial-stewardship-team-on-conversion-from-intravenous-to-oral-fluoroquinolones
#17
Soh Mee Park, Hyung Sook Kim, Young Mi Jeong, Jung Hwa Lee, Eunsook Lee, Euni Lee, Kyoung Ho Song, Hong Bin Kim, Eu Suk Kim
BACKGROUND: Early conversion from intravenous to oral antibiotics plays an important role in lowering the risk of catheter-associated infections, reducing the workload of nurses, decreasing direct and indirect costs, and shortening hospital stays. In August 2015, an antimicrobial stewardship program (ASP) was implemented to facilitate conversion from intravenous to oral administration of fluoroquinolones in our institute. This study evaluated the clinical and economic impact of the intervention...
March 13, 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28328218/functionalized-lanthanide-iii-complexes-constructed-from-azobenzene-derivative-and-%C3%AE-diketone-ligands-luminescent-magnetic-and-reversible-trans-to-cis-photoisomerization-properties
#18
Li-Rong Lin, Hui-Hui Tang, Yun-Guang Wang, Xuan Wang, Xue-Ming Fang, Li-Hua Ma
The coordination ability of ligands functionalized by azobenzene was manipulated, and two novel chelating ligands, (E)-4-(phenyldiazenyl)-N,N-bis(pyridin-2-ylmethyl) benzohydrazide (C25H22N6O, PBPM) and (E)-4-((4-(dimethylamino)phenyl)diazenyl)-N,N-bis(pyridin-2-ylmethyl) benzohydrazide (C27H27N7O, dmPBPM), were synthesized. The ligands can offer four coordinating atoms (one oxygen and three nitrogens) to act as tetradendate ligands, together with the two β-diketonates (4,4,4-trifluoro-1-phenylbutane-1,3-dionate, tfd), and the trifluoroacetate anion presented as a ligand and a counterion to form the quaternary units with lanthanide(III) ions (La, Eu, and Gd), [Ln(tfd)2(PBPM)(CF3CO2)] (LnC47H34F9N6O7) and [Ln(tfd)2(dmPBPM)(CF3CO2)] (LnC49H39F9N7O7), where the lanthanide(III) ions are nine coordinated with N3O6 donor sets...
March 22, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28327906/european-cancer-mortality-predictions-for-the-year-2017-with-focus-on-lung-cancer
#19
M Malvezzi, G Carioli, P Bertuccio, P Boffetta, F Levi, C La Vecchia, E Negri
Background: We predicted cancer mortality figures in the European Union (EU) for the year 2017 using most recent available data, with a focus on lung cancer. Materials and methods: We retrieved cancer death certification data and population figures from the World Health Organisation and Eurostat databases. Age-standardized (world standard population) rates were computed for France, Germany, Italy, Poland, Spain, the UK and the EU overall in 1970-2012. We obtained estimates for 2017 by implementing a joinpoint regression model...
February 21, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28327741/new-polyaminocarboxylate-macrocycles-containing-phenolate-binding-units-synthesis-luminescent-and-relaxometric-properties-of-their-lanthanide-complexes
#20
Morgane Enel, Nadine Leygue, Stéphane Balayssac, Sophie Laurent, Chantal Galaup, Luce Vander Elst, Claude Picard
The synthesis of two new polyaminocarboxylate macrocycles incorporating one or two intracyclic phenol units (H4L(1) and H8L(2), respectively) is described. The 12-membered H4L(1) macrocycle leads to soluble and stable mononuclear Ln(III) complexes of [(L(1))Ln(H2O)2](-) composition (Ln = Eu, Tb and Gd) in aqueous solutions. In Tris buffer (pH 7.4), the [(L(1))Tb(H2O)2](-) complex displays a suitable efficiency for sensitized emission (ηsens = 48%) and a high luminescence quantum yield (Φ = 22%), which is worthy of note for a bis-hydrated terbium complex...
March 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
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