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https://www.readbyqxmd.com/read/27910256/simultaneous-upgrading-of-furanics-and-phenolics-via-hydroxyalkylation-aldol-condensation-reactions
#1
Tuong V Bui, Tawan Sooknoi, Daniel E Resasco
The simultaneous conversion of cyclopentanone and m-cresol has been investigated on a series of solid acid catalysts. Both compounds are representative of biomass-derived streams. Cyclopentanone can be readily obtained from sugar-derived furfurals via Piancatelli rearrangement under reducing conditions. Cresol represents the family of phenolics, typically obtained from the depolymerization of lignin. In the first biomass conversion strategy proposed here, furfural is converted in high yields and selectivity to cyclopentanone (CPO) over metal catalysts such as Pd-Fe/SiO2 catalyst at 600 psia H2 and 150oC...
December 1, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27909953/the-pe%C3%A3-alosa-principle-of-transportation-democracy-lessons-from-bogot%C3%A3-on-the-morality-of-urban-mobility
#2
Shane Epting
The mayor of Bogotá, Enrique Peñalosa strives to deliver transit services that promote social equity through bicycle lanes, improved sidewalks, and a world-famous Bus Rapid Transit (BRT) system, "TransMilenio." Through examining the principles that guide his planning, we can flesh out a starting point for socially just transit systems. While such measures can alleviate several harms that transit systems cause, they rest on an incomplete foundation due to their top-down nature. To amend this situation, the author argues for a restorative justice approach to transportation democracy, using examples from Peñalosa's mayoral tenure...
December 1, 2016: Science and Engineering Ethics
https://www.readbyqxmd.com/read/27909557/eating-habits-physical-activity-nutrition-knowledge-and-self-efficacy-by-obesity-status-in-upper-grade-elementary-school-students
#3
Seong Ah Ha, Seo Yeon Lee, Kyung A Kim, Jung Sook Seo, Cheong Min Sohn, Hae Ryun Park, Kyung Won Kim
BACKGROUND/OBJECTIVES: Childhood obesity has increased in recent decades in Korea. This study was designed to examine differences in the eating habits, physical activity (PA), nutrition knowledge, and self-efficacy of children by obesity status. SUBJECTS/METHODS: Subjects were 5th-grade children from 70 elementary schools in 17 cities nationwide. Two-stage stratified cluster sampling was employed. Survey questionnaire included items related to general characteristics, eating habits, PA, nutrition knowledge and self-efficacy...
December 2016: Nutrition Research and Practice
https://www.readbyqxmd.com/read/27908792/freebie-rhabdomyolysis-a-public-health-concern-spin-class-induced-rhabdomyolysis-case-reports-and-review-of-literature
#4
Maureen Brogan, Rudrick Ledesma, Alan Coffino, Praveen N Chander
BACKGROUND: Rhabdomyolysis is a pathologic condition in which intracellular muscle constituents leak into the blood circulation. It is usually caused by muscle trauma. "Spinning" is an indoor form of cycling where participants use a special stationary exercise bicycle with a weighted flywheel and undergo high intensity cycling classes focusing on endurance. There have been several case reports in the literature of exertional rhabdomyolysis following spin class. METHODS: Our nephrology practices have diagnosed a number of cases of symptomatic patients presenting to our emergency departments following their first spin classes, with histories and creatinine phosphokinase levels diagnostic of exertional rhabdomyolysis...
November 28, 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27904756/ct-negative-mri-gre-positive-primary-motor-cortex-contusion-causing-isolated-foot-drop
#5
Alexander M Tucker, Tianyi Niu, Daniel T Nagasawa, Richard Everson, Shaina Sedighim, Manuel M Buitrago Blanco
BACKGROUND: Isolated acute foot drop due to traumatic brain injury is exceedingly rare and is often misdiagnosed during initial evaluation. Here, we present the case of a patient who presented with left foot drop after falling off a bicycle. CASE DESCRIPTION: The patient is a 55-year-old male who was mountain biking when he fell, hit his head, and lost consciousness. Neurologic examination of the left leg revealed foot drop, no sensory deficits, and 3+ reflexes at the knee and ankle with clonus...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27901269/ability-of-independently-ambulant-children-with-cerebral-palsy-to-ride-a-two-wheel-bicycle-a-case-control-study
#6
Rachel Toovey, Susan M Reid, Barry Rawicki, Adrienne R Harvey, Kerrianne Watt
AIM: Limited information exists on the ability of children with cerebral palsy (CP) to ride a two-wheel bicycle, an activity that may improve health and participation. We aimed to describe bicycle-riding ability and variables associated with ability to ride in children with CP (Gross Motor Functional Classification System [GMFCS] levels I-II) compared with children with typical development. METHOD: This case-control study surveyed parents of 114 children with CP and 87 children with typical development aged 6 to 15 years (115 males, mean age 9y 11mo, standard deviation [SD] 2y 10mo)...
November 30, 2016: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/27897367/bifunctionality-of-activ-as-a-cyclase-thioesterase-revealed-by-in-vitro-reconstitution-of-actinorhodin-biosynthesis-in-streptomyces-coelicolor-a3-2
#7
Takaaki Taguchi, Takayoshi Awakawa, Yukitaka Nishihara, Michiho Kawamura, Yasuo Ohnishi, Koji Ichinose
Type II polyketide synthase (PKS) iteratively generates a nascent polyketide thioester of acyl carrier protein (ACP), which is structurally modified to produce an ACP-free intermediate towards its final metabolite. However, the timing of ACP off-loading is not well defined due to the lack of an apparent thioesterase (TE) among relevant biosynthetic enzymes. Here, ActIV, which had been assigned as a second ring cyclase (CYC) in actinorhodin (ACT) biosynthesis, was shown to possess a TE activity in vitro with a model substrate, anthraquinone-2-carboxylic acid-N-acetylcysteamine...
November 29, 2016: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/27896333/shoulder-pain-after-falling-from-bicycle
#8
Baver Acar, Ozkan Kose
No abstract text is available yet for this article.
June 2016: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27890161/primary-or-secondary-tasks-dual-task-interference-between-cyclist-hazard-perception-and-cadence-control-using-cross-modal-sensory-aids-with-rider-assistance-bike-computers
#9
Chao-Yang Yang, Cheng-Tse Wu
This research investigated the risks involved in bicycle riding while using various sensory modalities to deliver training information. To understand the risks associated with using bike computers, this study evaluated hazard perception performance through lab-based simulations of authentic riding conditions. Analysing hazard sensitivity (d') of signal detection theory, the rider's response time, and eye glances provided insights into the risks of using bike computers. In this study, 30 participants were tested with eight hazard perception tasks while they maintained a cadence of 60 ± 5 RPM and used bike computers with different sensory displays, namely visual, auditory, and tactile feedback signals...
March 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/27890157/predicting-bicycle-setup-for-children-based-on-anthropometrics-and-comfort
#10
Karl Grainger, Zoe Dodson, Thomas Korff
Bicycling is a popular activity for children. In order for children to enjoy cycling and to minimize injury, it is important that they are positioned appropriately on the bicycle. The purpose of this study was therefore to identify a suitable bicycle setup for children aged between 7 and 16 years which accommodates developmental differences in anthropometrics, flexibility and perceptions of comfort. Using an adjustable bicycle fitting rig, we found the most comfortable position of 142 children aged 7 to 16...
March 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/27888214/cardiorespiratory-fitness-and-death-from-cancer-a-42-year-follow-up-from-the-copenhagen-male-study
#11
Magnus Thorsten Jensen, Andreas Holtermann, Hans Bay, Finn Gyntelberg
OBJECTIVES: Poor cardiorespiratory fitness (CRF) is associated with death from cancer. If follow-up time is short, this association may be confounded by subclinical disease already present at the time of CRF assessment. This study investigates the association between CRF and death from cancer and any cause with 42 years and 44 years of follow-up, respectively. SETTING, PARTICIPANTS AND MAIN OUTCOME MEASURES: Middle-aged, employed and cancer-free Danish men from the prospective Copenhagen Male Study, enrolled in 1970-1971, were included...
November 25, 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27887962/synthesis-of-a-biological-active-%C3%AE-hairpin-peptide-by-addition-of-two-structural-motifs
#12
Sabrina Fischer, Matthias Lamping, Maike Gold, Yvonne Röttger, Dörte Brödje, Richard Dodel, Renate Frantz, Mobarak Abu Mraheil, Trinad Chakraborty, Armin Geyer
The idea of privileged scaffolds - that there seem to be more bioactive compounds found around some structures than others - is well established for small drug molecules, but has little significance for standalone peptide secondary structures whose adaptable shapes escape the definition of a 3D motif in the absence of a protein scaffold. Here, we joined two independent biological functions in a single highly restricted peptide to support the hypothesis that the β-hairpin shape is the common basis of two otherwise unrelated biological recognition processes...
November 15, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27882694/fused-bicyclic-caspase-1-inhibitors-assembled-by-copper-free-strain-promoted-alkyne-azide-cycloaddition-spaac
#13
Linghui Qian, Chong-Jing Zhang, Ji'en Wu, Shao Q Yao
Challenges exist in the development of potent and selective small-molecule inhibitors against caspase-1. Herein, by making use of the copper-free strain-promoted alkyne-azide cycloaddition (SPAAC) reaction between difluorinated cyclooctynes (DIFOs) and various azide-containing compounds, we showed for the first time that potential caspase-1 inhibitors could be rapidly synthesized. The resulting fused bicyclic compounds structurally resembled the central portion (P2 -P3 ) of Pralnacasan (a well-known small molecule caspase-1 inhibitor), with diversity at the P4 -position of the parental inhibitor conveniently installed from the azide component...
November 24, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27882436/a-novel-4-6-disubstituted-1-2-4-triazolo-1-3-4-thiadiazole-derivative-inhibits-tumor-cell-invasion-and-potentiates-the-apoptotic-effect-of-tnf%C3%AE-by-abrogating-nf-%C3%AE%C2%BAb-activation-cascade
#14
Raghu Ningegowda, Nanjunda Swamy Shivananju, Peramiyan Rajendran, Basappa, Kanchugarakoppal S Rangappa, Arunachalam Chinnathambi, Feng Li, Raghu Ram Achar, Muthu K Shanmugam, Pradeep Bist, Sulaiman Ali Alharbi, Lina Hsiu Kim Lim, Gautam Sethi, Babu Shubha Priya
Condensed-bicyclic 4,6-substituted1,2,4-triazolo-1,3,4-thiadiazole derivatives (CBTT) have been shown to possess a wide spectrum of pharmacological activities. In this study, several novel CBTT derivatives were synthesized and investigated for their possible role as anti-neoplastic agents. The anti-proliferative effect of various CBTT derivatives was analyzed against tumor cell lines by (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) MTT assay. One of the potential CBTT derivative, 5-(3-(2,3-dichlorophenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)flurobenzonitrile (DTTF) was found to be the most potent against cervical cancer SiHa cells and exhibited minimal effect against normal cells...
November 24, 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/27881826/a-soft-wearable-microfluidic-device-for-the-capture-storage-and-colorimetric-sensing-of-sweat
#15
Ahyeon Koh, Daeshik Kang, Yeguang Xue, Seungmin Lee, Rafal M Pielak, Jeonghyun Kim, Taehwan Hwang, Seunghwan Min, Anthony Banks, Philippe Bastien, Megan C Manco, Liang Wang, Kaitlyn R Ammann, Kyung-In Jang, Phillip Won, Seungyong Han, Roozbeh Ghaffari, Ungyu Paik, Marvin J Slepian, Guive Balooch, Yonggang Huang, John A Rogers
Capabilities in health monitoring enabled by capture and quantitative chemical analysis of sweat could complement, or potentially obviate the need for, approaches based on sporadic assessment of blood samples. Established sweat monitoring technologies use simple fabric swatches and are limited to basic analysis in controlled laboratory or hospital settings. We present a collection of materials and device designs for soft, flexible, and stretchable microfluidic systems, including embodiments that integrate wireless communication electronics, which can intimately and robustly bond to the surface of the skin without chemical and mechanical irritation...
November 23, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27881469/the-role-of-intersection-and-street-design-on-severity-of-bicycle-motor-vehicle-crashes
#16
Morteza Asgarzadeh, Santosh Verma, Rania A Mekary, Theodore K Courtney, David C Christiani
BACKGROUND: Safety concerns are a major barrier to cycling. Intersection and street design variables such as intersection angles and street width might contribute to the severity of crashes and the safety concerns. In this study we examined whether these design variables were associated with bicycle-motor vehicle crashes (BMVC) severity. METHODS: Using the geographical information system and latitudes/longitudes recorded by the police using a global positioning device, we extracted intersection angles, street width, bicycle facilities, posted speed limits and annual average daily traffic from 3266 BMVC data from New York City police records...
November 9, 2016: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/27881424/temporal-reduction-in-chronotropic-index-predicts-risk-of-cardiovascular-death-among-healthy-middle-aged-men-a-28-year-follow-up-study
#17
Kristian Engeseth, Christian Hodnesdal, Irene Grundvold, Knut Liestøl, Knut Gjesdal, Sverre E Kjeldsen, Jan E Erikssen, Johan Bodegard, Per Torger Skretteberg
BACKGROUND: Chronotropic index is a standardized measure of heart rate (HR) increment during exercise that reflects the combined effects of age, resting HR, and physical fitness. Low chronotropic index has been reported to predict disease and death. We tested whether temporal change in chronotropic index over 7 years influenced risk of cardiovascular death through up to 28 years. METHODS AND RESULTS: Chronotropic index was calculated ([achieved maximal HR-resting HR]/[age-predicted maximal HR-resting HR]) after a symptom-limited bicycle ECG exercise test in 1420 healthy men at 2 examinations 7 years apart, in 1972 and 1979...
November 23, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27879636/chiral-hypervalent-pentacoordinated-phosphoranes
#18
REVIEW
Dorota Krasowska, Jacek Chrzanowski, Piotr Kiełbasiński, Józef Drabowicz
This review presents synthetic procedures applied to the preparation of chiral (mainly optically active) pentacoordinated, hypervalent mono and bicyclic phosphoranes. The mechanisms of their stereoisomerization and their selected interconversions are also presented.
November 21, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27876507/exercise-induced-cytokine-changes-in-antigen-stimulated-whole-blood-cultures-compared-to-serum
#19
C Pilat, K Krüger, T Frech, F C Mooren
Strenuous exercise is followed by an elevation of many cytokines with inflammation regulating properties. Since most cytokines act at pico- or nanomolar concentrations many investigations failed to detect their concentrations in vivo. Hence, the aim of this study was to evaluate the significance of cytokine measurements (IL-1β, TNF-α, IL-1ra, IL-6, CCL2 and CXCL8) in a stimulated whole-blood culture (sWBC) compared to serum with respect to their exercise-induced kinetics and detection rates. 40 male volunteers (age: 25,5 ± 4,3 years, BMI: 24,00 ± 2,24, VO2peak: 46,9 ± 4,1 ml/kg x min) performed 60 minutes of intensive bicycle exercise (80% VO2peak)...
November 19, 2016: Journal of Immunological Methods
https://www.readbyqxmd.com/read/27872887/mapping-cycling-patterns-and-trends-using-strava-metro-data-in-the-city-of-johannesburg-south-africa
#20
Walter Musakwa, Kadibetso M Selala
Plans for smart mobility through cycling are often hampered by lack of information on cycling patterns and trends, particularly in cities of the developing world such as Johannesburg. Similarly, traditional methods of data collection such as bicycle counts are often expensive, cover a limited spatial extent and not up-to-date. Consequently, the dataset presented in this paper illustrates the spatial and temporal coverage of cycling patterns and trends in Johannesburg for the year 2014 derived from the geolocation based mobile application Strava...
December 2016: Data in Brief
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