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https://www.readbyqxmd.com/read/29791476/identifying-county-characteristics-associated-with-resident-well-being-a-population-based-study
#1
Brita Roy, Carley Riley, Jeph Herrin, Erica S Spatz, Anita Arora, Kenneth P Kell, John Welsh, Elizabeth Y Rula, Harlan M Krumholz
BACKGROUND: Well-being is a positively-framed, holistic assessment of health and quality of life that is associated with longevity and better health outcomes. We aimed to identify county attributes that are independently associated with a comprehensive, multi-dimensional assessment of individual well-being. METHODS: We performed a cross-sectional study examining associations between 77 pre-specified county attributes and a multi-dimensional assessment of individual US residents' well-being, captured by the Gallup-Sharecare Well-Being Index...
2018: PloS One
https://www.readbyqxmd.com/read/29790643/the-association-of-bicycle-related-genital-numbness-and-sexual-health-inventory-for-men-score-shim-results-from-a-large-multinational-cross-sectional-study
#2
Nima Baradaran, Mohannad Awad, Thomas W Gaither, Kirkpatrick B Fergus, Benjamin E Cedars, Ashwin S Balakrishnan, Michael L Eisenberg, Tom Sanford, Benjamin N Breyer
OBJECTIVE: To assess the association of genital numbness and erectile dysfunction in male cyclists. SUBJECTS AND METHODS: Cyclists were recruited through Facebook advertisements and outreach to sporting clubs. This is a secondary analysis of a larger epidemiologic population-based study that examined sexual and urinary wellness in athletes. We queried cycling habits and erectile function using Sexual Health Inventory for Men (SHIM). RESULTS: A total of 2,774 male cyclists were included for the analysis...
May 23, 2018: BJU International
https://www.readbyqxmd.com/read/29790034/left-atrial-myocardial-dysfunction-after-chronic-abuse-of-anabolic-androgenic-steroids-a-speckle-tracking-echocardiography-analysis
#3
Antonello D'Andrea, Juri Radmilovic, Stefano Caselli, Andreina Carbone, Raffaella Scarafile, Simona Sperlongano, Gianpaolo Tocci, Tiziana Formisano, Francesca Martone, Biagio Liccardo, Michele D'Alto, Eduardo Bossone, Maurizio Galderisi, Paolo Golino
Anabolic-androgenic steroids (AAS) are used by power athletes to improve performance. However, the real effects of the chronic consumption of AAS on cardiovascular structures are subjects of intense debate. To detect by speckle tracking echocardiography (STE) underlying left atrial (LA) dysfunction in athletes abusing AAS and assess possible correlation between LA myocardial function and exercise capacity during cardiopulmonary stress test. 65 top-level competitive bodybuilders were selected (45 males), including 35 athletes misusing AAS for at least 5 years (users), 30 anabolic-free bodybuilders (non-users), compared to 40 age- and sex-matched healthy sedentary controls...
May 22, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29781280/unexpected-alkene-isomerization-during-iterative-cross-coupling-to-form-hindered-electron-deficient-trienes
#4
Abigail Feceu, Lauren E Sangster, David B C Martin
An iterative cross-coupling approach to conjugated trienes was explored as part of a planned stereoselective synthesis of bicyclic terpenes. Using a bifunctional bromoboronate building block, sequential Suzuki coupling reactions were employed to provide a conjugated trienone target containing a tetrasubstituted alkene. During the final cross-coupling step, an unexpected alkene isomerization was observed to give less hindered trans products. Examination of different substrates determined that conjugation to a ketone withdrawing group was responsible for isomerization, rather than steric hindrance of the tetrasubstituted alkene...
May 21, 2018: Organic Letters
https://www.readbyqxmd.com/read/29780808/real-time-observations-of-food-and-fluid-timing-during-a-120-km-ultramarathon
#5
Floris C Wardenaar, Daan Hoogervorst, Joline J Versteegen, Nancy van der Burg, Karin J Lambrechtse, Coen C W G Bongers
The aim of the present case study was to use real-time observations to investigate ultramarathon runners' timing of food and fluid intake per 15 km and per hour, and total bodyweight loss due to dehydration. The study included 5 male ultramarathon runners observed during a 120 km race. The research team members followed on a bicycle and continuously observed their dietary intake using action cameras. Hourly carbohydrate intake ranged between 22.1 and 62.6 g/h, and fluid intake varied between 260 and 603 mL/h...
2018: Frontiers in Nutrition
https://www.readbyqxmd.com/read/29780529/pd-ii-catalyzed-synthesis-of-bifunctionalized-carboranes-via-cage-b-h-activation-of-1-ch-2-nh-2-o-carboranes
#6
Xiaolei Zhang, Hong Yan
Aminoalkyl carboranes are anticipated to be valuable synthons toward the synthesis of bifunctionalized carboranes. However, direct cage boron derivation of these carborane derivatives has not been solved. Herein, the reversible conversion of catalytically infeasible o -carboranyl methylamines (1-CH2 NH2 - o -carboranes) into bidentate imines initiates Pd-mediated cage B-H activation. As a result, an amine coordinated bicyclic Pd(ii) complex ( 3 ) has been isolated and proven to be the catalytically active intermediate for highly site-selective B-H diarylation of o -carboranyl methylamines...
April 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/29779976/the-discovery-and-preclinical-evaluation-of-bms-707035-a-potent-hiv-1-integrase-strand-transfer-inhibitor
#7
B Narasimhulu Naidu, Michael A Walker, Margaret E Sorenson, Yasutsugu Ueda, John D Matiskella, Timothy P Connolly, Ira B Dicker, Zeyu Lin, Sagarika Bollini, Brian J Terry, Helen Higley, Ming Zheng, Dawn D Parker, Dedong Wu, Stephen Adams, Mark R Krystal, Nicholas A Meanwell
BMS-707035 is an HIV-1 integrase strand transfer inhibitor (INSTI) discovered by systematic optimization of N-methylpyrimidinone carboxamides guided by structure-activity relationships (SARs) and the single crystal X-ray structure of compound 10. It was rationalized that the unexpectedly advantageous profiles of N-methylpyrimidinone carboxamides with a saturated C2-substitutent may be due, in part, to the geometric relationship between the C2-substituent and the pyrimidinone core. The single crystal X-ray structure of 10 provided support for this reasoning and guided the design of a spirocyclic series 12 which led to discovery of the morpholino-fused pyrimidinone series 13...
May 14, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29777885/posttraumatic-cerebrospinal-fluid-leak-associated-with-an-upper-cervical-meningeal-diverticulum
#8
Noriya Enomoto, Hideo Mure, Toshiyuki Okazaki, Mai Azumi, Shinya Okita, Shinji Nagahiro, Yasushi Takagi
Spontaneous intracranial hypotension (SIH) has been increasingly recognized as a phenomenon caused by cerebrospinal fluid (CSF) leaks; however, its pathogenesis is still unclear. Here, we report two cases of SIH as a result of CSF leak from a meningeal diverticulum at the C2 nerve root sleeve. The first case is that of a 46-year-old man who had suffered from orthostatic headache after a bicycle accident at age 45. Computed tomography (CT) myelography revealed CSF leaks at the C1/2 level. He underwent epidural blood patch (EBP) therapy, but it was unsuccessful...
May 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29777847/cardiopulmonary-exercise-testing-limitation-in-peripheral-arterial-disease
#9
Zulfiqar Qutrio Baloch, Shabber Agha Abbas, Luke Marone, Abbas Ali
OBJECTIVE: PAD is associated with a markedly increased risk of cardiovascular mortality and remains under-recognized and under-treated. New screening approaches are needed to prevent disability in patients with PAD. METHODS: We performed a retrospective analysis of clinically stable cardiovascular patients who were referred for cardiopulmonary exercise testing (CPET) due to a variety of cardiovascular complaints. Amongst patients who prematurely terminated CPET, their available angiograms were assessed...
May 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29776517/fatally-injured-pedestrians-and-bicyclists-in-the-united-states-with-high-blood-alcohol-concentrations
#10
Angela H Eichelberger, Anne T McCartt, Jessica B Cicchino
INTRODUCTION: Little research has focused on the problem of alcohol impairment among pedestrians and bicyclists in the United States. The aim of the current study was to investigate the prevalence, trends, and characteristics of alcohol-impaired fatally injured pedestrians and bicyclists. METHOD: Data from the Fatality Analysis Reporting System (FARS) were analyzed for fatally injured passenger vehicle drivers, pedestrians, and bicyclists 16 and older during 1982-2014...
June 2018: Journal of Safety Research
https://www.readbyqxmd.com/read/29775886/sprint-interval-training-sit-substantially-reduces-depressive-symptoms-in-major-depressive-disorder-mdd-a-randomized-controlled-trial
#11
Alice Minghetti, Oliver Faude, Henner Hanssen, Lukas Zahner, Markus Gerber, Lars Donath
Continuous aerobic exercise training (CAT) is considered a complementary treatment option in patients with major depressive disorder (MDD). Intermittent exercise training protocols, such as sprint interval training (SIT) have gained increasing popularity, but no studies on depressive symptoms following SIT in patients with MDD are available. Fifty-nine in-patients with MDD were randomly assigned to a SIT or CAT group. Medication was counterbalanced in both intervention arms. Both intervention groups received 3 weekly training sessions for 4-weeks (12 sessions in total)...
May 8, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29774967/re-optimization-of-the-organocatalyzed-double-aldol-domino-process-to-a-key-enal-intermediate-and-its-application-to-the-total-synthesis-of-%C3%AE-%C3%A2-%C3%A2-prostaglandin-j%C3%A2
#12
Andrejs Pelss, Narasimhulu Gandhamsetty, James Robin Smith, Damien Mailhol, Mattia Silvi, Andrew Watson, Isabel Perez-Powell, Sébastien Prévost, Nina Schützenmeister, Peter Moore, Varinder Kumar Aggarwal
Re-investigation of the L-proline catalyzed double aldol cascade dimerization of succinaldehyde for the synthesis of a key bicyclic enal intermediate, pertinent in the field of stereoselective prostaglandin synthesis, is reported. The yield of this process has been more than doubled, from 14% to a 29% isolated yield on a multi-gram scale (32% NMR yield), through conducting a detailed study of the reaction solvent, temperature and concentration, as well as a catalyst screen. The synthetic utility of this enal intermediate has been further demonstrated through the total synthesis of Δ¹²-prostaglandin J₃, a compound with known anti-leukemic properties...
May 18, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29774613/divergent-enantioselective-synthesis-of-pyrroles-3h-pyrroles-and-bicyclic-imidazolines-by-ag-or-p-catalyzed-3-2-cycloaddition-of-allenoates-with-activated-isocyanides
#13
Yu Zhao, Germaine Pui Yann Kok, Pan-Lin Shao, Jia-Yu Liao, Siti Nur Fairuz Bte Sheikh Ismail, Weijun Yao, Yixin Lu
We report herein our detailed investigation of divergent, stereoselective formal [3 + 2] cycloadditions of allenoates with activated isocyanides catalyzed by silver or phosphine-based catalysts. Silver catalysis is capable of delivering a range of 3H-pyrroles in high stereoselectivities. These enantioenriched heterocycles can either undergo sequential cyclisation with isocyanoacetates to deliver unprecedented bicyclic imidazolines with excellent yields and stereoselectivity or undergo unusual aromatization pathways leading to poly-substituted pyrroles...
May 18, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29771957/salt-mine-microorganisms-used-for-the-biotransformation-of-chlorolactones
#14
Wanda Mączka, Małgorzata Grabarczyk, Katarzyna Wińska, Elżbieta Gębarowska, Tomasz Strzała, Marek Durajczyk
The aim of the project was to find new catalysts capable of chlorolactone biotransformation. Three bicyclic chlorolactones with structures possessing one or two methyl groups in their cyclohexane ring were subjected to screening biotransformation using seven bacterial strains and one fungal strain from a salt mine. Three strains of bacteria (Micrococcus luteus Pb10, Micrococcus luteus WSP45, Gordonia alkanivorans Pd25) and one fungal strain (Aspergillus sydowii KGJ10) were able to catalyse hydrolytic dehalogenation of one substrate...
2018: PloS One
https://www.readbyqxmd.com/read/29769832/validity-and-reliability-of-the-powertap-p1-pedals-power-meter
#15
Jesús G Pallarés, José Ramón Lillo-Bevia
To validate the new PowerTap P1® pedals power meter (PP1), thirty-three cyclists performed 12 randomized and counterbalanced graded exercise tests (100-500 W), at 70, 85 and 100 rev·min-1 cadences, in seated and standing positions. A scientific SRM system and a pair of PP1 pedals continuously recorded cadence and power output data. Significantly lower power output values were detected for the PP1 compared to the SRM for all workloads, cadences, and pedalling conditions (2-10 W, p < 0.05), except for the workloads ranged between 150 W to 350 W at 70 rev·min-1 in seated position (p > 0...
June 2018: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/29767676/complete-streets-and-adult-bicyclist-fatalities-applying-g-computation-to-evaluate-an-intervention-that-affects-the-size-of-a-population-at-risk
#16
Stephen J Mooney, Caroline Magee, Kolena Dang, Julie C Leonard, Jingzhen Yang, Frederick P Rivara, Beth E Ebel, Ali Rowhani-Rahbar, D Alex Quistberg
"Complete Streets" policies require transportation engineers to make provisions for pedestrians, cyclists and transit users. These policies may make bicycling safer for individual cyclists while increasing overall bicycle fatalities if more individuals cycle due to improved infrastructure. We merged county-level records of Complete Streets policies with Fatality Analysis Reporting System counts of cyclist fatalities occurring between January 2000 and December 2015. Because comprehensive county cycling estimates were not available, we used bicycle commute estimates from the American Community Survey and US Census as a proxy for the cycling population, and limited analysis to 183 counties (accounting for over half the US population) for which cycle commute estimates were consistently non-zero...
May 14, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29767227/effect-of-a-balance-training-programme-on-postural-balance-aerobic-capacity-and-frequency-of-falls-in-women-with-osteoporosis-a-randomized-controlled-trial
#17
Ibolya Miko, Imre Szerb, Anna Szerb, Tamas Bender, Gyula Poor
OBJECTIVE: To investigate the effect of a 12-month complex balance-training programme on static and dynamic postural balance, aerobic capacity and frequency of falls in women with established osteoporosis. DESIGN: Randomized controlled trial in which the intervention group was assigned a 12-month exercise programme (3 times a week for 30 min) and the control group had no intervention. SUBJECTS: A total of 100 osteoporotic women with at least one previous fracture...
May 16, 2018: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29766143/when-should-screening-of-pediatric-trauma-patients-for-adult-behaviors-start
#18
Adrian A Maung, Robert D Becher, Kevin M Schuster, Kimberly A Davis
Background: Care of patients with trauma is not only limited to the sustained physical injuries but also requires addressing social issues, such as substance abuse and interpersonal violence, which are responsible for trauma-related recidivism. This study investigates whether there are age-related variations in these problematic social behaviors to analyze whether there is an age cut-off at which point adolescents should be screened for adult social behaviors. Methods: Retrospective review of patients with trauma aged 12-21 admitted to an urban Level 1 adult and pediatric trauma center between February 2013 and April 2016...
2018: Trauma surgery & acute care open
https://www.readbyqxmd.com/read/29764241/lack-of-respiratory-and-ocular-effects-following-acute-propylene-glycol-exposure-in-healthy-humans
#19
Pamela Dalton, Brianna Soreth, Christopher Maute, Carolyn Novaleski, Marcy Banton
OBJECTIVE: Propylene glycol (PG) is a widely used solvent, chemical intermediate and carrier substance for foods, pharmaceutical and cosmetic products. Professional and occupational exposure to PG aerosol and vapor may occur from theatrical smoke generators and during application of deicing products to airplanes. While PG is considered to have low toxicity, the results of one study suggested that brief (1-min) exposure to PG mist elicited ocular and respiratory effects in humans. Because the high concentrations and brief exposure duration in that study were not representative of most occupational exposures, a controlled experimental exposure study was conducted to clarify or confirm the earlier findings...
May 15, 2018: Inhalation Toxicology
https://www.readbyqxmd.com/read/29763332/asymmetric-3-2-cycloaddition-employing-n-n-cyclic-azomethine-imines-catalyzed-by-chiral-at-metal-rhodium-complex
#20
Jun Gong, Qian Wan, Qiang Kang
An efficient asymmetric 1,3-dipolar cycloaddition of α,β-unsaturated 2-acyl imidazoles with N, N'-cyclic azomethine imines catalyzed by a chiral-at-metal rhodium complex is reported. The corresponding N, N'-bicyclic pyrazolidine derivatives with three contiguous tertiary stereocenters were obtained in good yields (up to 99%) with excellent stereoselectivities (>20:1 dr and >99% ee). Remarkably, as little as 0.5 mol % of a chiral Rh(III) complex can promote a gram-scale reaction with excellent yield and enantioselectivity...
May 15, 2018: Organic Letters
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