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https://www.readbyqxmd.com/read/28812886/room-temperature-ring-opening-of-quinoline-isoquinoline-and-pyridine-with-low-valent-titanium
#1
Seung-Yeol Baek, Takashi Kurogi, Dahye Kang, Masahiro Kamitani, Seongyeon Kwon, Douglas Solowey, Chun-Hsing Chen, Maren Pink, Patrick J Carroll, Daniel J Mindiola, Mu-Hyun Baik
The complex (PNP)Ti=CHtBu(CH2tBu) (PNP = N[2-PiPr2-4-methylphenyl]2-) dehydrogenates cyclohexane to cyclohexene by forming a transient low-valent titanium-alkyl species, [(PNP)Ti(CH2tBu)], which reacts with two equivalents of quinoline (Q) at room temperature to form H3CtBu and a Ti(IV) species where the less hindered C2=N1 bond of Q is ruptured and coupled to another equivalent of Q. The product isolated from this reaction is an imide with a tethered cycloamide group, (PNP)Ti=N[C18H13N] (1). Under photolytic conditions, intramolecular C-H bond activation across the imide-moiety in 1 occurs to form 2, and thermolysis reverses this process...
August 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28812404/effects-of-a-low-resistance-interval-bicycling-intervention-in-parkinson-s-disease
#2
Mehmet Uygur, Maria Bellumori, Christopher A Knight
Previous studies have shown that people with Parkinson's disease (PD) benefit from a variety of exercise modalities with respect to symptom management and function. Among the possible exercise modalities, speedwork has been identified as a promising strategy, with direct implications for the rate and amplitude of nervous system involvement. Considering that previous speed-based exercise for PD has often been equipment, personnel and/or facility dependent, and often time intensive, our purpose was to develop a population-specific exercise program that could be self-administered with equipment that is readily found in fitness centers or perhaps the home...
August 16, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28810083/self-cyclizing-antioxidants-to-prevent-dna-damage-caused-by-hydroxyl-radical
#3
Safnas F AbdulSalam, Purujit N Gurjar, Haizhou Zhu, Emma S Johnson, Jing Liu, Ana Luisa Kadekaro, Julio Landero-Figueroa, Edward Joseph Merino
Antioxidant therapy is a promising treatment strategy to protect DNA from damage caused by reactive oxygen species. Here we report novel self-cyclizing antioxidant reagents that are selective for hydroxyl radical. Our mechanistic investigation revealed that the reagents react with three equivalents of oxidant in a cascading reaction to form a bicyclic final product. Among the reagents synthesized 1c showed favourable properties in vitro and in cellular studies. Using As2O3, which triggers reactive oxygen species production, we showed 1c prevents formation of the guanine oxidation product 2,2,4-triamino-2H-oxazol-5-one-2'-deoxyribonucleoside and lowers levels of cellular reactive oxygen...
August 15, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28808202/-borneol-is-neuroprotective-against-permanent-cerebral-ischemia-in-rats-by-suppressing-production-of-proinflammatory-cytokines
#4
Lei Chang, Chun-Yu Yin, Hai-Yin Wu, Bin-Bin Tian, Yan Zhu, Chun-Xia Luo, Dong-Ya Zhu
Stroke is one of the leading causes of disability and death globally. It occurs when a major artery is occluded in the brain and leads to death of cells within the injured tissue. (+)-Borneol, a simple bicyclic monoterpene extracted from traditional Chinese medicine, is widely used in various types of diseases. However, no study has proved the effects of (+)-borneol on functional recovery from permanent ischemic stroke and the mechanism is still unknown. Here, we report that in the rat model of permanent cerebral ischemia, we found that (+)-borneol (1...
July 13, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28803767/semantic-control-deficits-impair-understanding-of-thematic-relationships-more-than-object-identity
#5
Hannah Thompson, James Davey, Paul Hoffman, Glyn Hallam, Rebecca Kosinski, Sarah Howkins, Emma Wooffindin, Rebecca Gabbitas, Elizabeth Jefferies
Recent work has suggested a potential link between the neurocognitive mechanisms supporting the retrieval of events and thematic associations (i.e., knowledge about how concepts relate in a meaningful context) and semantic control processes that support the capacity to shape retrieval to suit the circumstances. Thematic associations and events are inherently flexible: the meaning of an item changes depending on the context (for example, lamp goes with reading, bicycle and police). Control processes might stabilise weak yet currently-relevant interpretations during event understanding...
August 10, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28800368/unpredictability-does-not-hamper-nonretinotopic-motion-perception
#6
Marc M Lauffs, Haluk Ögmen, Michael H Herzog
The motion of parts of an object is usually perceived relative to the object, i.e., nonretinotopically, rather than in retinal coordinates. For example, we perceive a reflector to rotate on the wheel of a moving bicycle even though its trajectory is cycloidal on the retina. The rotation is perceived because the motion of the object (bicycle) is discounted from the motion of its parts (reflector). It seems that the visual system can easily compute the object motion and subtract it from the part motion. Bikes move usually rather predictably...
August 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28800241/diastereoselective-synthesis-of-diquinanes-and-triquinanes-bearing-vicinal-quaternary-carbon-stereocenters-from-acyclic-allene-based-precursors-via-a-cascade-reaction
#7
Shuang Li, Pengpeng Zhang, Yuanhe Li, Shumin Lu, Jianxian Gong, Zhen Yang
A cascade benzenethiol-mediated intramolecular [3 + 2] cycloaddition reaction between an allene and an α,β-unsaturated aldehyde or ester is developed for the diastereoselective synthesis of [3.3.0] bicyclic system bearing two quaternary atoms at their bridgehead positions. Notably, these structurally complex systems can be found in a wide range of natural products.
August 11, 2017: Organic Letters
https://www.readbyqxmd.com/read/28793052/cordyceps-sinensis-promotes-immune-regulation-and-enhances-bacteriostatic-activity-of-pa-824-via-il-10-in-mycobacterium-tuberculosis-disease
#8
D G Li, Z X Ren
PA-824 is a novel bicyclic nitroimidazole anti-tuberculosis (TB) drug. Cordyceps sinensis (Berk.) Sacc. (CS) was proven to be a good immunomodulatory compound. This research aimed to investigate the effect of CS on PA-824 in Mycobacterium tuberculosis (M.tb) infected mice (female CBA/J mice, 6 to 8 weeks of age and 20±2 g of weight). Mice were randomly assigned to 4 groups: PA-824, CS, PA-824+CS, and control. To verify the effect of PA-824 and CS on M.tb, after drug administration, mice lungs were harvested and bacterial colony formations were measured...
August 7, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28790513/the-jeremiah-metzger-lecture-cancer-in-the-twenty-first-century-an-inside-view-from-an-outsider
#9
Edward J Benz
Cancer is not a single disease. The term refers to literally hundreds of illnesses sharing common features: inappropriate proliferation of imperfectly differentiated cell types, invasion of nearby vital structures, and spread to distant sites (metastasis). Invasiveness and metastasis distinguish cancers from benign tumors such as fibroids and meningiomas. Yet, each type is distinct, possessed of defining morphologic, histologic, biochemical, and genomic features that have allowed oncologists to develop a nosology that guides diagnosis and therapy...
2017: Transactions of the American Clinical and Climatological Association
https://www.readbyqxmd.com/read/28789895/imidazo-1-2-%C3%AE-pyridines-possess-adenosine-a1-receptor-affinity-for-the-potential-treatment-of-cognition-in-neurological-disorders
#10
Roslyn Lefin, Mietha M van der Walt, Pieter J Milne, Gisella Terre'Blanche
Previous research has shown that bicyclic 6:5-fused heteroaromatic compounds with two N-atoms have variable degrees of adenosine A1 receptor antagonistic activity. Prompted by this imidazo[1,2-α]pyridine analogues were synthesized and evaluated for their adenosine A1 and A2A receptor affinity via radioligand binding studies and subjected to a GTP shift assay to determine its adenosine A1 receptor agonistic or antagonistic functionality. Imidazo[1,2-α]pyridine, the parent scaffold, was found devoid of affinity for the adenosine A1 and A2A receptors...
July 29, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28783355/iminosugar-c-nitromethyl-glycosides-and-divergent-synthesis-of-bicyclic-iminosugars
#11
Sure Siva Prasad, Soundararasu Senthilkumar, Akriti Srivastava, Sundarababu Baskaran
An efficient one-pot method for the stereoselective synthesis of novel iminosugar C-nitromethyl glycosides is described. This new class of iminosugar glycosides has versatile nitromethyl functionality whose utility was further demonstrated in the single-step synthesis of bicyclic iminosugars. Under reagent-free conditions, the N-allyl-C-nitromethyl glycosides resulted in intramolecular cyclization to iminosugar-oximes, whereas under SET oxidation, they furnished cyclopropane-fused iminosugars. The N-propargyl-C-nitromethyl glycosides underwent an unprecedented ketenimine-acrylamidine-Michael addition cascade reaction to give bicyclic amidines...
August 7, 2017: Organic Letters
https://www.readbyqxmd.com/read/28781179/injuries-and-illnesses-occurring-on-a-recreational-bicycle-tour-the-great-ohio-bicycle-adventure
#12
Thomas L Pommering, Diane C Manos, Bhavna Singichetti, Chelsea R Brown, Jingzhen Yang
OBJECTIVE: Recreational multiday cycling events have grown popular in the United States; however, little has been published regarding the injuries and illnesses that occur during these events. The objective of this study was to describe injuries and illnesses that occur in the Great Ohio Bicycle Adventure (GOBA) and to examine associated risk factors. METHODS: Injury and illness data collected from an on-site medical clinic during the 2013 and 2014 GOBA tours were merged with rider registration data for analysis...
August 3, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28780860/selective-catalytic-b-h-arylation-of-o-carboanyl-aldehydes-by-a-transient-directing-strategy
#13
Xiaolei Zhang, Hongning Zheng, Jie Li, Fei Xu, Jing Zhao, Hong Yan
Carboranyl aldehydes are among the most useful synthons in derivatization of carboranes. However, compared to the utilization of carboranyl carboxylic acids in selective B-H bond functionalizations, the synthetic application of carboranyl aldehydes is limited due to the weakly coordinating nature of aldehyde group. Herein, the direct arylation of o-carboranyl aldehydes has been developed via Pd-catalyzed cage B-H bond functionalization. With the help of glycine to generate a directing group (DG) in situ, a series of cage B(4,5)-diarylated- and B(4)-monoarylated-o-carboranyl aldehydes were obtained in good to excellent yields with high selectivity...
August 6, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28780534/applying-the-health-action-process-approach-to-bicycle-helmet-use-and-evaluating-a-social-marketing-campaign
#14
Florian M Karl, Jennifer Smith, Shannon Piedt, Kate Turcotte, Ian Pike
BACKGROUND: Bicycle injuries are of concern in Canada. Since helmet use was mandated in 1996 in the province of British Columbia, Canada, use has increased and head injuries have decreased. Despite the law, many cyclists do not wear a helmet. Health action process approach (HAPA) model explains intention and behaviour with self-efficacy, risk perception, outcome expectancies and planning constructs. The present study examines the impact of a social marketing campaign on HAPA constructs in the context of bicycle helmet use...
August 5, 2017: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/28778011/dynamic-bicycle-exercise-to-assess-cardiac-output-at-multiple-exercise-levels-during-magnetic-resonance-imaging
#15
Johan Heiberg, Benjamin Asschenfeldt, Marie Maagaard, Steffen Ringgaard
PURPOSE: The aim was to establish a method for performing dynamic exercise during magnetic resonance imaging (MRI) using a slowly increasing workload protocol. METHODS: An ergometer bicycle with a step-wise, exercise protocol was used. Real-time phase-contrast MRI images of the aorta were obtained at each exercise step. RESULTS: In total, 40 participants completed the exercise protocol to reach a mean maximum cardiac output of 13.7±3.7l/min and a heart rate of 150±16beats/min at the highest exercise level...
July 27, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28776333/the-prevalence-of-drinking-and-biking-and-associated-risk-factors-the-korea-national-health-and-nutrition-examination-survey
#16
Se Hwan Hwang, Ma Rhip Ahn, Kyung Do Han, Jung Ho Lee
With the steady rise of health and environmental awareness, the number of bicyclists is increasing. However, there are few epidemiologic studies on bicycling under the influence (BUI). The aim of this study was to determine the prevalence of BUI and the associated risk factors in a representative Korean population. The data of 4,833 adult bicyclists who participated in the Korean National Health and Nutrition Examination Survey (2010-2012) were analyzed. Among the 4,833 participants investigated in this study, 586 (12...
September 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28774897/generating-a-city-s-first-report-on-bicyclist-safety-lessons-from-the-field
#17
Dahianna S Lopez, David Hemenway
BACKGROUND: For cities aiming to create a useful surveillance system for bicycle injuries, a common challenge is that city crash reporting is scattered, faulty or non-existent. We document some of the lessons we learnt in helping the city of Boston, Massachusetts, USA, do the following: (1) Create a prototype for a comprehensive police crash data set (2) Produce the city's first cyclist safety report, (3) Make crash data available to the public and (4) Generate policy recommendations for both specific roadside improvements and for sustainable changes to the police department's crash reporting database...
August 3, 2017: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/28770598/expanding-hiv-testing-and-linkage-to-care-in-southwestern-uganda-with-community-health-extension-workers
#18
REVIEW
Stephen Asiimwe, Jennifer M Ross, Anthony Arinaitwe, Obed Tumusiime, Bosco Turyamureeba, D Allen Roberts, Gabrielle O'Malley, Ruanne V Barnabas
INTRODUCTION: Achieving the UNAIDS goals of 90-90-90 will require more than doubling the number of people accessing HIV care in Uganda. Community-based programmes for entry into HIV care are effective strategies to expand access to HIV care, but few programmes have been evaluated with a particular focus on scale-up. METHODS: Integrated Community Based Initiatives, a Uganda-based non-governmental organization, designed and implemented a programme of community-based HIV counselling and testing and facilitated linkage to care utilizing community health extension workers (CHEWs) in rural Sheema District, Uganda...
July 21, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28764763/the-shrinking-health-advantage-unintentional-injuries-among-children-and-youth-from-immigrant-families
#19
Natasha Ruth Saunders, Alison Macpherson, Jun Guan, Lisa Sheng, Astrid Guttmann
BACKGROUND: Immigrants typically arrive in good health. This health benefit can decline as immigrants adopt behaviours similar to native-born populations. Risk of injury is low in immigrants but it is not known whether this changes with increasing time since migration. We sought to examine the association between duration of residence in Canada and risk of unintentional injury. METHODS: Population-based cross-sectional study of children and youth 0 to 24 years in Ontario, Canada (2011-2012), using linked health and administrative databases...
August 1, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28762596/effectiveness-of-home-based-exercise-in-older-patients-with-advanced-chronic-obstructive-pulmonary-disease-a-3-year-cohort-study
#20
Ritsuko Wakabayashi, Yuji Kusunoki, Kumiko Hattori, Takashi Motegi, Ryuko Furutate, Aki Itoh, Rupert Cm Jones, Michael E Hyland, Kozui Kida
AIM: To determine whether home-based exercise can improve clinical outcomes in older patients with advanced chronic obstructive pulmonary disease using long-term oxygen therapy. METHODS: Information was provided to improve chronic obstructive pulmonary disease self-management before the onset of the present prospective 3-year cohort study. Patients selected either home-based exercise using a lower-limb cycle machine (ergo-bicycle; group E), or usual exercise (group U)...
August 1, 2017: Geriatrics & Gerontology International
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