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Jian Jin, Zhenggong Wang, Huiting Ren, Shenxiang Zhang, Feng Zhang
Carbon molecular sieve (CMS) membrane based membrane attracts great attentions because of their outstanding gas separation performance. Polymer precursor is one of key points for preparation of high performance CMS. Tröger's base (TB) group is constructed by a bridged bicyclic amine. Such a bicyclic bridged stereo structure endows TB unit with highly contorted and great shape-persistent properties. In this work, a TB-based PIM-PI (TB-PI) is used as a polymer precursor to prepare CMS for the first time. By optimizing the thermal treatment condition, three CMS membranes treated under different soaking temperatures named TB-CMS-550, TB-CMS-650, and TB-CMS-800 were obtained...
January 19, 2018: ChemSusChem
Shoko Kimata, Takuya Matsuda, Yuta Suizu, Yoichi Hayakawa
Roseophilin (2) is a unique prodigiosin-related compound produced by Streptomyces griseoviridis 2464-S5, and is characterized by a central furan ring and a bicyclic alkyl chain. During a search for biosynthetic intermediates of 2, a new metabolite designated prodigiosin R2 (1) was isolated from the culture of the roseophilin producer. The molecular formula of 1 was established as C27H35N3O by high-resolution FAB-MS. The structure of 1 was determined by NMR spectroscopic analyses as a prodigiosin derivative with the same bicyclic alkyl chain as 2...
January 18, 2018: Journal of Antibiotics
Shani Batcir, Itshak Melzer
Older adults gain many health benefits from riding bicycles regularly. We aimed to explore whether older persons who ride bicycles regularly have better balance than controls. Balance control and voluntary stepping were assessed in 20 older adults aged 65 to 85 who live in an agricultural community village who regularly ride bicycles (BR), and 30 age- and gender-matched non-bicycle riders (NBR). Self-reported function and fear of fall were also assessed. Bicycle riders showed significantly better balance, faster voluntary stepping, and better self-reported advanced lower extremity function compared with NBR...
January 18, 2018: Journal of Aging and Physical Activity
Diego A Arroyo, Sara Schukraft, Zacharenia Kallinikou, Jean-Christophe Stauffer, Gérard Baeriswyl, Jean-Jacques Goy, Mario Togni, Stéphane Cook, Serban Puricel
Aims: To compare endothelium-dependent vasomotor function and vascular healing 15 months after implantation of two new-generation drug-eluting stents and biovascular scaffolds (BVS). Methods and results: A total of 28 patients previously treated with a SYNERGY stent (bioabsorbable polymer everolimus-eluting stents (BP-EES)), a PROMUS stent (persistent polymer everolimus-eluting stents (PP-EES)) or an ABSORB (BVS) underwent control coronary angiography, 15 months after implantation, coupled with optical coherence tomography imaging and supine bicycle exercise...
2018: Open Heart
Daniel H De La Iglesia, Juan F De Paz, Gabriel Villarrubia González, Alberto L Barriuso, Javier Bajo, Juan M Corchado
Nowadays, many citizens have busy days that make finding time for physical activity difficult. Thus, it is important to provide citizens with tools that allow them to introduce physical activity into their lives as part of the day's routine. This article proposes an app for an electric pedal-assist-system (PAS) bicycle that increases the pedaling intensity so the bicyclist can achieve higher and higher levels of physical activity. The app includes personalized assist levels that have been adapted to the user's strength/ability and a profile of the route, segmented according to its slopes...
January 14, 2018: Sensors
Dana Baron Shahaf, Sapir Bar, Ronit Leiba, Vered Dvir, Itai Shavit
OBJECTIVE: Emergency department (ED) visits due to concussion have increased over recent years. We aimed to identify variables associated with unscheduled adolescents return to the ED. METHODS: A retrospective cohort study was conducted. All children aged 11 to 18 years who were admitted to the ED due to concussion between 2011 and 2016 were included. Multivariable logistic regression was performed to identify predictors of ED return. RESULTS: Overall, 616 adolescents were admitted to the ED due to concussion...
January 17, 2018: Brain Injury: [BI]
Aleksey V Zerov, Galina L Starova, Vitalii V Suslonov, Olesya V Khoroshilova, Aleksander V Vasilyev
Trimethylsilyl ethers of 1,5-diaryl-3-(trifluoromethyl)pent-1-en-4-yn-3-oles in superacid CF3SO3H (TfOH) give rise to the corresponding intermediate CF3-pentenynyl cations. These species react with benzene to afford conjugated CF3-pentenynes, which undergo subsequent cyclization, first, into CF3-cycloheptadienes and, finally, into unusual CF3-"helicopter"-like bicyclic structures.
January 17, 2018: Organic Letters
Zhe Meng, Bo Liu
The first total syntheses of five natural eremophilane-type sesquiterpenoids were achieved in 4-12 steps via a common synthetic intermediate. The syntheses feature a double Michael addition, Robinson annulation, α-enolization of an unsaturated ketone, and Pd-catalyzed Suzuki coupling reaction to install the side chain. This synthetic strategy could be easily extended to other eremophilane-type sesquiterpenoids with similar bicyclic skeletons.
January 17, 2018: Organic & Biomolecular Chemistry
Daniel Dominguez Ferraz, Karen Valadares Trippo, Gabriel Pereira Duarte, Mansueto Gomes Neto, Kionna Oliveira Bernardes Santos, Jamary Oliveira Filho
OBJECTIVES: To compare the effects of functional training, bicycle exercise and exergaming on walking capacity of elderly with Parkinson disease (PD). DESIGN: A pilot randomized controlled single-blinded trial. SETTING: A State Reference Health Care Centre for Elderly, a public reference outpatient clinic for the elderly. PARTICIPANTS: Sixty-two elderly individuals (≥60 years-old) with idiopathic PD (stage 2 to 3 of modified Hoehn and Yahr) according to the London Brain Bank...
January 11, 2018: Archives of Physical Medicine and Rehabilitation
Jaehoon Sim, Hyunkyung Park, Juhee Lim, Inah Yoon, Changjin Lim, Hongchan An, Hwayoung Yun, Hyun Jin Choi, Young-Ger Suh
The first total synthesis of (-)-dendroside C aglycon, consisting of a 1,4,5-tri-cis-guaiane skeleton, from a versatile hydroazulene intermediate has been accomplished. The key features of the syntheses include the stereoselective preparation of the unusual cis-hydroazulene core via a sequence of a unique Dieckmann condensation of the bicyclic lactone system, which was concisely prepared by the tandem conjugate addition and intramolecular allylic alkylation of a butenolide precursor, and construction of the characteristic tricyclic skeleton by a carbene-mediated cyclopropanation...
January 16, 2018: Organic Letters
Guoqing Hu, Daoxin Yin
No abstract text is available yet for this article.
January 15, 2018: BMJ: British Medical Journal
Qian-Qian Yang, Wei Xiao, Wei Du, Qin Ouyang, Ying-Chun Chen
An efficient double catalytic system, combining chiral amine and 2-mercaptobenzoic acid, is applied for α',β-regioselective [4+2] annulations of 2-cyclopentenone with a diversity of activated alkenes, constructing multifunctional chiral bicycle[2,2,1]heptane scaffolds in good to excellent yields and enantioselectivities. In comparison with the traditional cross-dienamine species between 2-cyclopentenone and chiral amine, the interrupted enamine intermediate containing a covalently linked thiol catalyst shows significantly improved reactivity...
January 15, 2018: Chemical Communications: Chem Comm
M Broufa, S Wassertheurer, B Hametner, R Zweiker, R K Binder, T Weber
Background: Pulsatile hemodynamics are associated with left ventricular filling pressures and diastolic dysfunction. We investigated their relationship with maximum workload and peak oxygen uptake (peak VO2) in patients with exertional dyspnea and preserved left ventricular ejection fraction (LVEF). Methods: Radial waveforms from tonometry were processed with a transfer function, pulse wave analysis and wave separation analysis, yielding central aortic pressures and measures of forward (amplitude of forward wave-Pf) and reflected waves (Augmentation Index-AIx, Augmentation Pressure-AP, amplitude of backward wave-Pb) and their ratio (Reflection Magnitude-RM)...
January 9, 2018: American Journal of Hypertension
Karin Hermon, Tali Capua, Miguel Glatstein, Dennis Scolnik, Oren Tavor, Ayelet Rimon
BACKGROUND: Electric bicycles (E-bikes) are one of a wide range of light electric vehicles that provide convenient local transportation and attractive recreational opportunities. The aim of this study was to report E-bike-related injuries in children presenting to a trauma center. METHODS: Retrospective observational study, from December 2014 to November 2015, which included all pediatrics patients admitted to the emergency department with an injury related to E-bike use, was performed...
January 11, 2018: Pediatric Emergency Care
Lana Popovic-Maneski, Antonina Aleksic, Amine Metani, Vance Bergeron, Radoje Cobeljic, Dejan B Popovic
Increased muscle tone and exaggerated tendon reflexes characterize most of the individuals after a spinal cord injury (SCI). We estimated seven parameters from the pendulum test and used them to compare with the Ashworth modified scale of spasticity grades in three populations (retrospective study) to assess their spasticity. Three ASIA B SCI patients who exercised on a stationary FES bicycle formed group F, six ASIA B SCI patients who received only conventional therapy were in the group C, and six healthy individuals constituted the group H...
January 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
Lucas Zellmer, Nathan Fleming
BACKGROUND: Wheels For All provides bicycles to individuals in La Crosse, Wisconsin to address the transportation barrier that often inhibits low-income individuals' ability to access community resources. METHODS: Recipients are referred by social service, health care, or other community agencies based on their need for transportation or exercise. Donated bicycles are matched to a recipient, repaired, and delivered personally by volunteers. RESULTS: Through collaboration with social service agencies, health care systems, and the community at-large, Wheels For All received referrals from 21 different sources and provided 101 recipients with bicycles from April 2015 to July 2017...
August 2017: WMJ: Official Publication of the State Medical Society of Wisconsin
Rebecca Bernstein, Robert Schneider, Whitney Welch, Anne Dressel, Melissa DeNomie, Jennifer Kusch, Mirtha Sosa
INTRODUCTION: This pilot study tested the efficacy of a bicycling intervention targeting inactive, low-income, overweight adults on reducing perceived barriers to bicycling, increasing physical activity, and improving health. METHODS: A nonblinded 2-site randomized controlled trial was conducted in Milwaukee, Wisconsin, in summer 2015. Participants included members from 1 largely Latino community and a second primarily African American neighborhood. A certified bicycling instructor led a 12-week bicycling intervention...
August 2017: WMJ: Official Publication of the State Medical Society of Wisconsin
Esma B Boydas, Gamze Tanriver, Matthias D'hooghe, Hyun-Joon Ha, Veronique Van Speybroeck, Saron Catak
Transient bicyclic aziridinium ions are known to undergo ring-expansion reactions, paving the way to functionalized nitrogen-containing heterocycles. In this study, the regioselectivity observed in the ring-expansion reactions of 1-azoniabicyclo[n.1.0]alkanes was investigated from a computational viewpoint to study the ring-expansion pathways of two bicyclic systems with different ring sizes. Moreover, several nucleophiles leading to different experimental results were investigated. The effect of solvation was taken into account using both explicit and implicit solvent models...
January 11, 2018: Organic & Biomolecular Chemistry
Ye Li, Lu Xing, Wei Wang, Mingzhang Liang, Hao Wang
As a booming system, free-floating bicycle-sharing (denoted as Mobike) attracts a large number of users due to the convenient utilization procedure. However, it brings about a rapid increase of bicycle volume on roadways, resulting in safety problems especially on road segments shared by automobiles and bikes. This study aimed to evaluate impacts of Mobike on automobile-involved bicycle crashes on shared roadways at a macro level, the network level. Relation between traffic volumes and crashes was first established...
January 6, 2018: Accident; Analysis and Prevention
Yunyun Li, Fang Xie, Yuan Liu, Xifa Yang, Xingwei Li
The synthsis of fluorinated isoxazolidines in bicyclic settings has been realized via Ru(II)-catalyzed C-H activation of aryl nitrones with perfluoroalkyl-substituted olefins as the coupling partner. The reaction proceeded via initial chelation-assisted C(aryl)-H allylation followed by regio- and diastereoselective intramolecular dipolar addition between the nitrone directing group and the olefin unit.
January 9, 2018: Organic Letters
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