Read by QxMD icon Read


Kaiyue Zang, Jie Shen, Haosheng Huang, Mi Wan, Jiafeng Shi
The surface roughness of roads is an essential road characteristic. Due to the employed carrying platforms (which are often cars), existing measuring methods can only be used for motorable roads. Until now, there has been no effective method for measuring the surface roughness of un-motorable roads, such as pedestrian and bicycle lanes. This hinders many applications related to pedestrians, cyclists and wheelchair users. In recognizing these research gaps, this paper proposes a method for measuring the surface roughness of pedestrian and bicycle lanes based on Global Positioning System (GPS) and accelerometer sensors on bicycle-mounted smartphones...
March 19, 2018: Sensors
Alban Zarzavadjian Le Bian, Philippe Wind
No abstract text is available yet for this article.
March 21, 2018: JAMA Surgery
Alex Antonio Florindo, Ligia Vizeu Barrozo, Gavin Turrell, João Paulo Dos Anjos Souza Barbosa, William Cabral-Miranda, Chester Luiz Galvão Cesar, Moisés Goldbaum
Cities that support cycling for transportation reap many public health benefits. However, the prevalence of this mode of transportation is low in Latin American countries and the association with facilities such as bike paths and train/subway stations have not been clarified. We conducted a cross-sectional analysis of the relationship between bike paths, train/subway stations and cycling for transportation in adults from the city of Sao Paulo. We used data from the Sao Paulo Health Survey ( n = 3145). Cycling for transportation was evaluated by a questionnaire and bike paths and train/subway stations were geocoded using the geographic coordinates of the adults' residential addresses in 1500-m buffers...
March 21, 2018: International Journal of Environmental Research and Public Health
Kaveh Matinkhoo, Alla Pryyma, Mihajlo Todorovic, Brian O Patrick, David M Perrin
α-Amanitin is an extremely toxic bicyclic octapeptide isolated from the death-cap mushroom, Amanita phalloides. As a potent inhibitor of RNA polymerase II, α-amanitin is toxic to eukaryotic cells. Recent interest in α-amanitin arises from its promise as a payload for antibody-drug conjugates. For over 60 years, A. phalloides has been the only source of α-amanitin. Here we report a synthesis of α-amanitin, which surmounts the key challenges for installing the 6-hydroxy-tryptathionine sulfoxide bridge, enantioselective synthesis of (2 S,3 R,4 R)-4,5-dihydroxy-isoleucine, and diastereoselective sulfoxidation...
March 21, 2018: Journal of the American Chemical Society
Anthony Bouillod, Julien Pinot, Aurélien Valade, Johan Cassirame, Georges Soto-Romero, Frédéric Grappe
This study was designed to examine the influence of standing position (vs. seated) during uphill cycling on both mechanical cost (MC) and energy cost (EC) in elite cyclists. For the study, thirteen elite cyclists (VO2max : 71.4 ± 8.0 ml·min-1 ·kg-1 ) performed, in a randomised order, three sets of exercises. Each set comprised 2 min of exercise, alternating every 30 s between seated and standing postures, using different slopes and intensity levels on a motorised treadmill. MC was calculated from the measurement of power output and speed, whereas EC was calculated from the measurement of oxygen consumption and speed...
March 7, 2018: Journal of Biomechanics
Laura Montoya-Sánchez, Rocío Del P Pereira-Ospina, Javier Y Pinzón-Salamanca, José M Suescún-Vargas
Pancreatitis consists in acute inflammation of the pancreas that is clinically characterized by abdominal pain. To make the diagnosis it is necessary the elevation of biochemical markers like pancreatic amylase or lipase. It is the most frequent pancreatic disease in both children and adults. Its presentation in the pediatric population is increasing and has several etiologies such as: infections, trauma, intoxication and metabolic diseases. Trauma mechanisms have been described: child maltreatment, falls, trauma with the bicycle handle and traffic accidents...
April 1, 2018: Archivos Argentinos de Pediatría
Thomas Ratschiller, Hannes Müller, Thomas Schachner, Andreas Zierer
We report a case of a 64-year-old man who developed a painful pulsatile mass in the distal forearm after a bicycle fall with fracture of the wrist. Ultrasonography confirmed a 2.5-cm large pseudoaneurysm of the radial artery. The patient underwent surgical exploration. The pseudoaneurysm was resected and the defect in the arterial wall was reconstructed with an autologous saphenous vein patch. We suggest that the double arterial supply of the hand should be preserved whenever possible.
January 1, 2018: Vascular and Endovascular Surgery
Ryoma Michishita, Masanori Ohta, Masaharu Ikeda, Ying Jiang, Hiroshi Yamato
AIM: This study was designed to examine the associations between an exaggerated systolic blood pressure (SBP) response to exercise and the nutrient intake in normotensive subjects. METHODS: The subjects consisted of 302 normotensive subjects (64 males and 238 females; age, 48.4 ± 11.3 years) without a history of cardiovascular disease or stroke who were not taking any medications. Each subject performed a multistage graded submaximal exercise stress test using an electric bicycle ergometer, and their blood pressure was measured at rest and during the last minute of each stage...
March 19, 2018: Clinical and Experimental Hypertension: CHE
Thomas W Gaither, Mohannad A Awad, Gregory P Murphy, Ian Metzler, Thomas Sanford, Michael L Eisenberg, Siobhan Sutcliffe, E Charles Osterberg, Benjamin N Breyer
BACKGROUND: Bicycle riding has become an increasingly popular mode of transportation and exercise, especially among women, and previous studies have demonstrated a relationship between cycling and sexual dysfunction, albeit using non-validated questionnaires. AIM: We aimed to explore the relationship between cycling and sexual and urinary dysfunction. METHODS: Cyclists were recruited to complete a survey through Facebook advertisements and outreach to sporting clubs across 5 English-speaking countries...
March 6, 2018: Journal of Sexual Medicine
Xiangyu Chang, Jingzhou Shen, Xiaoling Lu, Shuai Huang
The emerging Bicycle Sharing System (BSS) provides a new social microscope that allows us to "photograph" the main aspects of the society and to create a comprehensive picture of human mobility behavior in this new medium. BSS has been deployed in many major cities around the world as a short-distance trip supplement for public transportations and private vehicles. A unique value of the bike flow data generated by these BSSs is to understand the human mobility in a short-distance trip. This understanding of the population on short-distance trip is lacking, limiting our capacity in management and operation of BSSs...
2018: PloS One
Pei Huang, Yuanqing Li, Xiao-Guang Yu, Wei-Bin Zhu, Shu-Yan Nie, Hao Zhang, Jin-Rui Liu, Ning Hu, Shao-Yun Fu
The mimicry of human skin to detect both oncoming and physical-contacting object is of great importance in the fields of manufacturing, artificial robots and vehicles, etc. Herein, a novel bio-inspired flexible and highly responsive dual-mode strain/magnetism composite sensor which works via both contact and contactless modes, is first fabricated by incorporating Fe3O4/silicone system into a carbon fiber aerogel. The distance-dependence of magnetic field endorses the CFA/Fe3O4/silicone composite possible for spatial sensing due to the introduction of Fe3O4 magnetic nanoparticles...
March 15, 2018: ACS Applied Materials & Interfaces
Jessica Hill, Johnathan Matlock, Quentin Lefebvre, Katie Cooper, Jonathan Clayden
Tetrahydroisoquinolines and tetrahydrobenzazepines are prepared by acid-promoted ring contraction of cyclic ureas, themselves formed by ring expansion of indolines and tetrahydroquinolines. The consequent overall one-carbon insertion reaction gives these 6- and 7-membered heterocyclic scaffolds in three steps from readily available precursors. Other ring sizes may be formed by an alternative elimination reaction of bicyclic structures. Scalability of the method was demonstrated by operating it in a flow system...
March 14, 2018: Angewandte Chemie
Juan Pan, Minakshi Bhardwaj, Bo Zhang, Wei-Chen Chang, Christopher Lewis Schardl, Carsten Krebs, Robert B Grossman, J Martin Bollinger
The core of the loline family of insecticidal alkaloids is the bicyclic pyrrolizidine unit with an additional strained ether bridge between carbons 2 and 7. Previously reported genetic and in vivo biochemical analyses showed that the presumptive iron- and 2-oxoglutarate-dependent (Fe/2OG) oxygenase, LolO, is required for installation of the ether bridge upon the pathway intermediate, 1- exo-acetamidopyrrolizidine (AcAP). Here we show that LolO is, in fact, solely responsible for this biosynthetic four-electron oxidation...
March 14, 2018: Biochemistry
Chao Li, Shanshan Zheng, Jingwen Chen, Hong-Bin Xie, Ya-Nan Zhang, Yuanhui Zhao, Zheng Du
Understanding the atmospheric fate of organophosphorus plasticizers is important for their environmental risk assessment. However, limited information is available at present. In this study, density functional theory (DFT) calculations were performed to investigate the transformation mechanism and kinetics of tri-p-cresyl phosphate (TpCP) initiated by OH. Results show that the initial reactions are dominated by H-abstraction and OH addition to form TpCP-radical, TpCP-OH adducts and aryl phosphodiester. The H-abstraction pathways are more favorable than the OH addition pathways...
March 7, 2018: Chemosphere
Ivan Andreevich Yaremenko, Gabriel Dos Passos Gomes, Peter Sergeevich Radulov, Yulia Yur'evna Belyakova, Anatoliy Evgen'evich Vilikotskiy, Vera Andreevna Vil', Alexander A Korlyukov, Gennady Ivanovich Nikishin, Igor V Alabugin, Alexander Olegovich Terent'ev
Reactions of 1,5-diketones with H2O2 open an ozone-free approach to ozonides. Bridged ozonides are formed readily at the room temperature in the presence of strong Brønsted or Lewis acids such as H2SO4, p-TsOH, HBF4, or BF3•Et2O. The expected bridged tetraoxanes, the products of double H2O2 addition, were not detected. This procedure is readily scalable to produce gram quantities of the ozonides. Bridged ozonides are stable and can be useful as building block for bioconjugation and further synthetic transformations...
March 13, 2018: Journal of Organic Chemistry
Irina Velikyan, Örjan Lindhe
Monitoring general disease marker such as angiogenesis may contribute to the development of personalized medicine and improve therapy outcome. Readily availability of positron emitter based imaging agents providing quantification would expand clinical positron emission tomography (PET) applications. Generator produced68 Ga provides PET images of high resolution and the half-life time frame is compatible with the pharmacokinetics of small peptides comprising arginine-glycine-aspartic acid (RGD) sequence specific to αv β3 integrin receptors...
2018: American Journal of Nuclear Medicine and Molecular Imaging
Iker Riaño, Uxue Uria, Efraim Reyes, Luisa Carrillo, Jose L Vicario
A diastereodivergent approach to highly substituted bicyclo[3.1.0]hexanes has been developed through a transannular alkylation reaction that builds up the bicyclic core employing asymmetric organocatalysis as the tool for the installation of all stereocenters. On one hand, a Michael/Michael cascade process between enals and 4-alkenyl sulfamidate imines under the iminium/enamine activation manifold provides a oxathiazole-2,2-dioxide-fused cyclohexane adduct that, after isolation, is subsequently engaged in a transannular alkylation/hydrolysis through enamine activation by the use of a primary amine...
March 12, 2018: Journal of Organic Chemistry
Júlia García-Pindado, Tom Willemse, Rebecca Goss, Bert U W Maes, Ernest Giralt, Steven Ballet, Meritxell Teixidó
While revisiting biologically active natural peptides, the importance of the tryptophan residue became clear. In this article, the incorporation of this amino acid, brominated at different positions of the indole ring, into cyclic peptides was successfully achieved. These products demonstrated improved properties in terms of passive diffusion, permeability across membranes, biostability in human serum and cytotoxicity. Moreover, these brominated tryptophans at positions 5, 6, or 7 proved to be compatible as building blocks to prepare bicyclic stapled peptides by performing on-resin Suzuki-Miyaura cross-coupling reactions...
March 12, 2018: Biopolymers
Teemu Niemi, Israel Fernández, Bethany Steadman, Jere K Mannisto, Timo Repo
We report herein a straightforward general method for the synthesis of cyclic carbamates from amino alcohols and carbon dioxide in the presence of an external base and a hydroxyl group activating reagent. Utilizing p-toluenesulfonyl chloride (TsCl), the reaction proceeds under mild conditions, and the approach is fully applicable to the preparation of various high value-added 5- and 6-membered rings as well as bicyclic fused ring carbamates. DFT calculations and experimental results indicate a SN 2-type reaction mechanism with high regio-, chemo-, and stereoselectivity...
March 12, 2018: Chemical Communications: Chem Comm
Shotaro Kawakami, Tetsuhiko Yasuno, Takuro Matsuda, Kanta Fujimi, Ai Ito, Saki Yoshimura, Yoshinari Uehara, Hiroaki Tanaka, Takao Saito, Yasuki Higaki
BACKGROUND: High-intensity exercise reduces renal blood flow (RBF) and may transiently exacerbate renal dysfunction. RBF has previously been measured invasively by administration of an indicator material; however, non-invasive measurement is now possible with technological innovations. This study examined variations in RBF at different exercise intensities using ultrasound echo. METHODS: Eight healthy men with normal renal function (eGFRcys 114 ± 19 mL/min/1...
March 10, 2018: Clinical and Experimental Nephrology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"