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https://www.readbyqxmd.com/read/28432611/comparison-of-human-erythrocyte-purine-nucleotide-metabolism-and-blood-purine-and-pyrimidine-degradation-product-concentrations-before-and-after-acute-exercise-in-trained-and-sedentary-subjects
#1
Wioleta Dudzinska, M Suska, A Lubkowska, K Jakubowska, M Olszewska, K Safranow, D Chlubek
This study aimed at evaluating the concentration of erythrocyte purine nucleotides (ATP, ADP, AMP, IMP) in trained and sedentary subjects before and after maximal physical exercise together with measuring the activity of purine metabolism enzymes as well as the concentration of purine (hypoxanthine, xanthine, uric acid) and pyrimidine (uridine) degradation products in blood. The study included 15 male elite rowers [mean age 24.3 ± 2.56 years; maximal oxygen uptake (VO2max) 52.8 ± 4.54 mL/kg/min; endurance and strength training 8...
April 21, 2017: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/28429730/new-bicyclic-cembranoids-from-the-south-china-sea-soft-coral-sarcophyton-trocheliophorum
#2
Lin-Fu Liang, Wen-Ting Chen, Xu-Wen Li, He-Yao Wang, Yue-Wei Guo
Nine new bicyclic cembranoids, sarcophytrols M-U(1-9), were isolated from the South China Sea soft coral Sarcophyton trocheliophorum as minor components, along with one known related cembranoid 10. Their structures were elucidated by detailed spectroscopic analysis and chemical conversion. The chemical structures of these metabolites are characterized by the different patterns of the additional cyclization within the 14-member skeleton, which leading to the formation of furan, pyran, oxepane, and peroxyl rings, respectively...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28429384/enantioselective-silver-and-amine-co-catalyzed-desymmetrizing-cycloisomerization-of-alkyne-linked-cyclohexanones
#3
Rubén Manzano, Swarup Datta, Robert S Paton, Darren J Dixon
A silver(I) and amine co-catalyzed desymmetrization of 4-propargylamino cyclohexanones for the direct enantioselective synthesis of 2-azabicyclo[3.3.1]nonanes is described. Exploiting reactivity arising from dual activation of the pendant terminal alkyne by silver(I) and the ketone moiety through transient enamine formation, this synthetically relevant transformation is easy to perform, efficient and broad in scope. High enantioselectivity (up to 96 % ee) was achieved by exploiting a significant matching effect between the chirality of a cinchona alkaloid-derived aminophosphine ligand for the silver(I) salt and the 2-bis(aryl)methylpyrrolidine catalyst which was rationalized by DFT calculations...
April 21, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28427814/design-synthesis-and-x-ray-structural-studies-of-bace-1-inhibitors-containing-substituted-2-oxopiperazines-as-p1-p2-ligands
#4
Arun K Ghosh, Margherita Brindisi, Yu-Chen Yen, Emilio L Cárdenas, Jean-Rene Ella-Menye, Nagaswamy Kumaragurubaran, Xiangping Huang, Jordan Tang, Andrew D Mesecar
We report the design and synthesis of a series of BACE1 inhibitors incorporating mono- and bicyclic 6-substituted 2-oxopiperazines as novel P1' and P2' ligands and isophthalamide derivative as P2-P3 ligands. Among mono-substituted 2-oxopiperazines, inhibitor 5a with N-benzyl-2-oxopiperazine and isophthalamide showed potent BACE1 inhibitory activity (Ki=2nM). Inhibitor 5g, with N-benzyl-2-oxopiperazine and substituted indole-derived P2-ligand showed a reduction in potency. The X-ray crystal structure of 5g-bound BACE1 was determined and used to design a set of disubstituted 2-oxopiperazines and bicyclic derivatives that were subsequently investigated...
April 8, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28426228/ultrafast-dynamics-of-a-triazene-excited-state-pathways-and-the-impact-of-binding-to-the-minor-groove-of-dna-and-further-biomolecular-systems
#5
Lena Grimmelsmann, Alireza Marefat Khah, Christian Spies, Christof Hättig, Patrick Nuernberger
Many synthetic DNA minor groove binders exhibit a strong increase in fluorescence when bound to DNA. The pharmaceutical-relevant berenil (diminazene aceturate) is an exception with an extremely low fluorescence quantum yield (on the order of 10(-4)). We investigate the ultrafast excited-state dynamics of this triazene by femtosecond time-resolved fluorescence experiments in water, ethylene glycol, and buffer and bound to the enzyme β-trypsin, the minor groove of AT-rich DNA, and G-quadruplex DNA. Ab initio calculations provide additional mechanistic insight...
April 20, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28424870/high-intensity-interval-training-does-not-impair-strength-gains-in-response-to-resistance-training-in-premenopausal-women
#6
Paulo Gentil, Claudio Andre Barbosa de Lira, Suedi Gonçalves Cardoso Filho, Cauê Vazquez La Scala Teixeira, James Steele, James Fisher, Juliana Alves Carneiro, Mário Hebling Campos
PURPOSE: To compare the increases in upper- and lower-body muscle strength in premenopausal women performing resistance training (RT) alone or alongside concurrent high-intensity interval training (CT). METHODS: Sixteen women (26-40 years) were randomly assigned into two groups that performed either RT or CT. Both groups performed the same RT program; however, CT performed additional high-intensity interval training (HIIT) on a bicycle ergometer before RT. The study lasted 8 weeks and the participants were tested for ten repetition maximum (10RM) load in elbow flexion (barbell biceps curl) and knee extension exercises pre- and post-intervention...
April 19, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28424620/relations-between-effects-and-structure-of-small-bicyclic-molecules-on-the-complex-model-system-saccharomyces-cerevisiae
#7
Matteo Brilli, Andrea Trabocchi, Tobias Weil, Duccio Cavalieri, Irene Stefanini
The development of compounds able to modify biological functions largely took advantage of parallel synthesis to generate a broad chemical variance of compounds to be tested for the desired effect(s). The budding yeast Saccharomyces cerevisiae is a model for pharmacological studies since a long time as it represents a relatively simple system to explore the relations among chemical variance and bioactivity. To identify relations between the chemical features of the molecules and their activity, we delved into the effects of a library of small compounds on the viability of a set of S...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28424132/outcomes-of-recreational-activity-associated-trauma-in-elderly-persons-on-blood-thinning-medications
#8
Zachary M DeBoard, Jonathan Grotts, Lisa Ferrigno
With increasing life expectancy, the elderly are participating in recreational activities traditionally pursued by younger persons. Elderly patients have many reasons for worse outcomes after trauma, one of which may be the rising use of anticoagulant and/or antiplatelet medications. This study aimed to determine whether preinjury use of these agents yielded worse outcomes in geriatric patients injured during high-impact recreational activities. The National Trauma Data Bank was reviewed from 2007 to 2010 for patients ≥65 years admitted to Level I or II trauma centers with ICD-9 E-codes for specific mechanisms of injury...
April 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28422547/active-travel-behavior-in-a-border-region-of-texas-and-new-mexico-motivators-deterrents-and-characteristics
#9
Ipek N Sener, Richard J Lee
BACKGROUND: Active travel has been linked with improved transportation and health outcomes, such as reduced traffic congestion and air pollution, improved mobility, accessibility and equity, and increased physical and mental health. The purpose of this study was to better understand active travel characteristics, motivators, and deterrents in the El Paso, Texas, region. METHODS: A multimodal transportation survey brought together elements of transportation and health, with a focus on attitudinal characteristics...
April 19, 2017: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/28422267/cycling-in-canada
#10
Pamela L Ramage-Morin
This article provides an overview of cycling, including fatalities and bicycle helmet use, based on data from the 1994/1995 National Population Health Survey, the 2013/2014 Canadian Community Health Survey and the Vital Statistics-Death Database. In 2013/2014, an estimated 7.0 million Canadians aged 12 or older (24%) reported cycling in the previous three months, compared with 6.5 million (29%) in 1994/95. The prevalence of cycling declined with age, and was more common among males and people living in higher-income and -education households...
April 19, 2017: Health Reports
https://www.readbyqxmd.com/read/28421971/-posttraumatic-appendicitis
#11
S Klis, T L Trang, M F Lutke Holzik
BACKGROUND: Posttraumatic appendicitis is an appendicitis that develops as a consequence of abdominal trauma. Trauma is a relatively rare cause of appendicitis which is nowadays rarely mentioned in surgical textbooks. CASE DESCRIPTION: We describe the case of a 12-year-old girl who presented to the emergency department six days after abdominal trauma caused by a fall from an electrical bicycle, complaining of fever and abdominal pain. Her symptoms were caused by a perforated appendicitis...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28418658/cp-rh-iii-bicyclic-olefin-co-catalyzed-c-h-bond-amidation-by-intramolecular-amide-transfer
#12
Xiaoming Wang, Tobias Gensch, Andreas Lerchen, Constantin G Daniliuc, Frank Glorius
A bicyclic olefin was discovered as a co-catalyst in a Cp*Rh(III)-catalyzed C-H bond amidation proceeding by an intramolecular amide transfer in N-phenoxyacetamide derivatives. Combining experimental and theoretical studies, we propose that the olefin promotes a Rh(III) intermediate to undergo oxidative addition into the O-N bond to form a Rh(V) nitrenoid species and subsequently direct the nitrenoid to add to the ortho position. The amide directing group plays a dual role as a cleavable coordinating moiety as well as an essential coupling part-ner for the C-H amidation...
April 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28415098/p569diastolic-dyssynchrony-is-associated-with-exercise-intolerance-in-hypertensive-patients-with-left-ventricular-hypertrophy
#13
I H Jung, H S Seo, M J Kim
Background: Left ventricular hypertrophy (LVH) is associated with intra-ventricular dyssynchrony at systolic phase during exercise in hypertensive patients. However, dypsnea on exertion is much more correlated with diastolic phase. We investigated whether LVH is associated with diastolic dyssynchrony during exercise in patients with hypertension. Methods: Ninety hypertensive patients with exertional dyspnea and 30 control individuals were enrolled. Exercise stress echocardiography was performed using a symptom limited, multistage supine bicycle test...
December 1, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28414588/prehospital-predictors-of-traumatic-spinal-cord-injury-in-victoria-australia
#14
Alaa O Oteir, Karen Smith, Johannes Stoelwinder, James W Middleton, Shelley Cox, Lisa N Sharwood, Paul A Jennings
OBJECTIVES: To identify the predictors of traumatic spinal cord injury (TSCI) and describe the differences between confirmed and potential TSCI cases in the prehospital setting. METHODS: A retrospective cohort study including all adult patients over a six-year period (2007-12) with potential TSCI who were attended and transported by Ambulance Victoria (AV). We extracted potential TSCI cases from the AV data warehouse and linked with the Victorian State Trauma Registry to compare with final hospital diagnosis...
April 17, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28412692/review-research-on-the-physical-training-model-of-human-body-based-on-hq
#15
Liu Junjie
Health quotient (HQ) is the newest health culture and concept in the 21st century, and the analysis of the human body sports model is not enough mature at present, what's more, the purpose of this paper is to study the integration of the two subjects the health quotient and the sport model. This paper draws the conclusion that physical training and education in colleges and universities can improve the health quotient, and it will make students possess a more healthy body and mind. Then through a new rigid body model of sports to simulate the human physical exercise...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28409387/fatal-abdominal-injuries-in-a-bicycle-pedestrian-collision-reconstruction-using-multibody-simulation
#16
Holger Muggenthaler, Stefanie Drobnik, Michael Hubig, Wolfgang Fiebig, Gita Mall
Fatal bicycle-pedestrian collisions do not occur frequently and thus are rarely reported in literature. Pedestrians in bicycle-pedestrian accidents often sustain severe craniocerebral injuries caused by a collision induced fall with head impact on the road surface. We describe a case where a pedestrian crossing a road was hit by a bicycle. Hematomas of the left lower leg and of the left flank/abdomen were found to be caused by the primary impact. However, the fatal injuries were found to be contralateral with a rupture of the right renal pedicle, a rupture of the right lobe of the liver and a tear of the vena cava...
April 13, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/28407711/using-ring-strain-to-control-4%C3%AF-electrocyclization-reactions-torquoselectivity-in-ring-closing-of-medium-ring-dienes-and-ring-opening-of-bicyclic-cyclobutenes
#17
Byron A Boon, Aaron G Green, Peng Liu, K N Houk, Craig A Merlic
Syntheses of strained cyclic dienes were accomplished via palladium(II)-catalyzed oxidative cyclizations of terminal bis(vinylboronate esters). The reactions generate strained (E,E)-1,3-dienes that undergo spontaneous 4π-electrocyclizations to form bicyclic cyclobutenes. Formation of the cyclobutenes is driven by the strain in the medium-ring (E,E)-1,3-diene intermediate. Thermal ring openings of the cyclobutenes give (Z,Z)-1,3-diene products, again for thermodynamic reasons. DFT calculations verified the thermodynamic versus kinetic control of the reactions, and kinetic studies are in excellent agreement with the calculated energy changes...
April 21, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28407710/generation-of-triplet-excited-states-via-photoinduced-electron-transfer-in-meso-anthra-bodipy-fluorogenic-response-towards-singlet-oxygen-in-solution-and-in-vitro
#18
Mikhail A Filatov, Safakath Karuthedath, Pavel M Polestshuk, Huguette Savoie, Keith J Flanagan, Cindy Sy, Elisabeth Sitte, Maxime Telitchko, Frédéric Laquai, Ross W Boyle, Mathias O Senge
Heavy atom-free BODIPY-anthracene dyads (BADs) upon photoexcitation generate locally excited triplet excited states by way of photoinduced electron transfer (PeT), followed by recombination of the resulting charge-separated states (CSS). Subsequent quenching of the triplet states by molecular oxygen produces singlet oxygen ((1)O2), which reacts with the anthracene moiety yielding highly fluorescent species. The steric demand of the alkyl substituents in the BODIPY subunit defines the site of (1)O2 addition...
April 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28407668/type-2-diabetes-is-associated-with-lower-cardiorespiratory-fitness-independent-of-pulmonary-function-in-severe-obesity
#19
Britta Wilms, Barbara Ernst, Martin Thurnheer, Christina M Spengler, Bernd Schultes
Both severe obesity and type 2 diabetes (T2DM) are associated with reduced pulmonary function and reduced cardiorespiratory fitness. We investigated whether T2DM further aggravates the impaired pulmonary function and cardiorespiratory fitness in subjects with severe obesity. In this cross-sectional study pulmonary function (forced expiratory volume within 1 s, FEV1; vital capacity, VC) was assessed in 65 severely obese subjects with T2DM (T2DM group) and 65 severely obese subjects without T2DM (non-T2DM group), pairwise matched for sex, age, weight, and height...
April 13, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28407111/road-injuries-health-burden-but-not-fatalities-make-12-to-17-year-olds-a-high-risk-group-in-the-netherlands
#20
Divera A M Twisk, Niels M Bos, Wendy A M Weijermars
To explore the impact of road injuries for different age groups, this study compares the health burden of road injuries in young adolescents-12 to 17 years of age-to those for older age groups. Young adolescents are underrepresented in road fatalities. However, their inexperience, developmental stage and use of bicycles may expose them to high levels of road risk, but their physical resilience may help them survive injuries which in older age groups would be fatal. To assess the impact of injuries compared with death, this study assessed by age group the health burden expressed in disability adjusted life years; years of life lost plus years lived with disability...
April 11, 2017: European Journal of Public Health
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