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https://www.readbyqxmd.com/read/28437813/presenting-symptoms-of-pituitary-apoplexy
#1
Efstratios-Stylianos Pyrgelis, Ioannis Mavridis, Maria Meliou
The classical term "pituitary apoplexy" (PA) describes a clinical syndrome usually characterized by abrupt onset of headache accompanied by neurologic and/or endocrinologic deterioration due to sudden expansion of a mass within the sella turcica as a result of hemorrhage or infarction within a pituitary tumor and adjacent pituitary gland. PA is a medical emergency and a difficult diagnosis to establish. Thus this article reviews the presenting symptoms of PA patients to help clinicians recognize or at least suspect this critical condition early on...
April 24, 2017: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/28383841/-atypical-presentation-of-a-breast-cancer-pituitary-metastasis
#2
J Langrand-Escure, A Vallard, J-Ph Suchaud, P Diao, N Magné
Pituitary metastasis occur in 1-5 % of patients with cancer. We report the discovery of a unique pituitary metastasis of breast cancer. A 67 years old woman was treated in 2003 for local adenocarcinoma. After bone metastatic relapse in 2008, the patient developed diplopia and diabetes insipidus. An MRI revealed a histologically proven metastatic pituitary nodule. Further explorations revealed failure of multiple endocrine axes. Pituitary metastases are relatively rare, but are probably under-diagnosed in the presence of advanced cancers with impaired general condition...
July 2016: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28367946/a-case-of-herpes-zoster-ophthalmicus-preceded-one-week-by-diplopia-and-ophthalmalgia
#3
Tomohiro Ota, Yusuke Toda, Akiko Ozawa, Mineo Yamazaki, Kazumi Kimura
A 66-year-old man presented with headache and ophthalmalgia. Diplopia developed, and he was hospitalized. The left eye had abducent paralysis and proptosis. We diagnosed him with Tolosa-Hunt syndrome and administered methylprednisolone at 1 g/day for 3 days. However, the patient did not respond to treatment. No abnormality was found on his MRI or cerebrospinal fluid examination. Tests showed his serum immunoglobulin G4 and antineutrophil cytoplasmic antibody titers were within normal limits. He also had untreated diabetes mellitus (HbA1c 9...
March 30, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/28201864/recurrent-contrast-induced-encephalopathy-following-coronary-angiography
#4
Roberto Spina, Neil Simon, Romesh Markus, David W M Muller, Krishna Kathir
Contrast-induced encephalopathy (CIE) is an acute and reversible neurological disturbance associated with the intra-arterial administration of iodinated contrast medium during cardiac catheterisation. It may manifest with encephalopathy, motor and sensory disturbances; vision disturbances, including cortical blindness, ophthalmoplegia, aphasia; and seizures. Disruption of the blood-brain barrier and direct neuronal toxicity are believed to be implicated in the pathophysiology of the syndrome. Symptoms appear soon after contrast administration and resolve completely within 24-48 h...
February 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28097453/seven-cases-of-localized-invasive-sino-orbital-aspergillosis
#5
Hideaki Kawakami, Kiyofumi Mochizuki, Kyoko Ishida, Kiyofumi Ohkusu
PURPOSE: To describe the clinical manifestations and prognoses in 7 patients with invasive sino-orbital aspergillosis (ISOA). METHODS: This was a retrospective study of consecutive patients who were diagnosed as having ISOA at the Gifu University Hospital and Gifu Municipal Hospital between January 1993 and December 2015. Data were collected on demographics, initial manifestations, examination findings, treatments, clinical course, and outcomes. RESULTS: The median age of the 7 patients with ISOA was 68 years; 5 of them had diabetes...
March 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28061417/concurrent-hyphema-and-orbital-apex-syndrome-following-herpes-zoster-ophthalmicus-in-a-middle-aged-lady
#6
Khairuddin Othman, Li Min Evelyn-Tai, Mohd Noor Raja-Azmi, Muhammed Julieana, Ahmad Tajudin Liza-Sharmini, John Tharakan, Alwi Muhd Besari, Embong Zunaina, Ismail Shatriah
INTRODUCTION: Hyphema and orbital apex syndrome occurring concurrently in a patient with herpes zoster ophthalmicus have not been reported previously. We present a case with these unique findings and discuss the pathogenesis of these conditions and their management. PRESENTATION OF CASE: A 59-year-old Malay lady with underlying diabetes mellitus presented with manifestations of zoster ophthalmicus in the left eye. Two weeks later, she developed total hyphema, and complete ophthalmoplegia suggestive of orbital apex syndrome...
December 21, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27940680/wernicke-encephalopathy-in-adolescents-after-bariatric-surgery-case-report-and-review
#7
Amy Armstrong-Javors, Janey Pratt, Sigmund Kharasch
Roughly 1% of all weight loss surgery is performed in adolescents. There is strong evidence demonstrating significant postsurgical weight loss, improvement in quality of life, and reduction in comorbidities such as hypertension and diabetes. Reports of postoperative complications in adolescents are few because of the small sample size in most series. Despite vitamin supplementation, nutritional deficiencies requiring hospitalization occur occasionally after Roux-en-Y gastric bypass. Wernicke encephalopathy, a triad of ophthalmoplegia, ataxia, and altered mental status, is a serious consequence of thiamine (vitamin B1) deficiency...
December 2016: Pediatrics
https://www.readbyqxmd.com/read/27633123/hypophyseal-metastases-a-report-of-three-cases-and-literature-review
#8
REVIEW
Janez Ravnik, Tomaz Smigoc, Gorazd Bunc, Bostjan Lanisnik, Ursa Ksela, Maja Ravnik, Tomaz Velnar
Metastatic tumours to the pituitary gland are rare. The most frequent are metastases from breast and lung. We describe three patients with metastatic tumours: (I) a 54-year-old patient with metastatic renal clear-cell carcinoma and consequent disturbances in visual acuity, cranial nerve paresis and panhypopituitarism, (II) a 60-year-old patient with a diffuse large B-cell lymphoma with panhypopituitarism and diabetes insipidus and (III) a 57-year-old patient with metastasis of breast cancer and panhypopituitarism, visual impairment and cranial nerve paresis...
November 2016: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/27449153/assessment-of-the-prevalence-and-risk-factors-of-ophthalmoplegia-among-diabetic-patients-in-a-large-national-diabetes-registry-cohort
#9
Eman S Al Kahtani, Rajiv Khandekar, Khalid Al-Rubeaan, Amira M Youssef, Heba M Ibrahim, Ahmed H Al-Sharqawi
BACKGROUND: There are limited data on the epidemiology and risk factors of ophthalmoplegia among diabetic patients. This study aims to determine the prevalence and important risk factors related to ophthalmoplegia among diabetic patients. METHODS: This is an observational registry-based study using the Saudi National Diabetes Registry (SNDR) database to select diabetic patients regardless of their diabetes type. A total of 64,351 Saudi diabetic patients aged more than 18 years and registered in SNDR between January 2000 and December 2010 were analyzed to identify ophthalmoplegic cases...
July 22, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27272179/acute-invasive-fungal-rhinosinusitis-our-experience-with-18-cases
#10
Mehdi Bakhshaee, Amin Bojdi, Abolghasem Allahyari, Mohammad Reza Majidi, Sherwin Tavakol, Mohammad Javad Najafzadeh, Masoud Asghari
Acute invasive fungal rhinosinusitis (AIFRS) is a rapidly progressive life threatening infection that is seen most commonly among immunocompromised patients. We present a case series of 18 patients clinically and histopathologically diagnosed with AIFRS with a mean follow-up of 9.11 ± 2.51 months (range 6-17). Demographic data, apparent symptoms and signs, underlying disorders, and outcomes are discussed. The mean age was 39.56 ± 20.66 years (range 2-75). The most common underlying diseases were diabetes mellitus (50 %) and leukemia (44...
December 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27256997/lethargy-and-vision-loss-successful-management-of-rhinocerebral-mucormycosis
#11
Ramzi Mulki, Muhammad Masab, Glenn Eiger, Sarah Perloff
Rhinocerebral mucormycosis (RCM) is an angioinvasive fungal infection most often caused by Rhizopus oryzae It is usually associated with an underlying risk factor and is associated with a poor prognosis. There are no consensus guidelines on the optimal management of this aggressive disease; most management decisions are based on case reports and expert opinion. We report a successfully managed case of RCM in an insulin-dependent diabetic, initially presenting with a change in mental status, rapidly progressing to complete right eye blindness and ophthalmoplegia and complicated by multiple cerebral infarctions and abscesses...
June 2, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/26297877/the-pescatorial-sixth
#12
Francesco Pellegrini, Giovanni Prosdocimo, Jason J S Barton
A 56-year-old man with diabetes presented with acute diplopia and signs of bilateral complete abduction deficits. Diffuse areflexia was his only other sign at presentation. Within a few days, he developed complete ophthalmoplegia and ataxia, consistent with a clinical diagnosis of Miller-Fisher syndrome, and repeated history revealed a possible gastroenteritis 3 weeks prior. This case illustrates an "ophthalmoplegia without ataxia" variant of this classic autoimmune condition, which should be considered in patients presenting with bilateral VI nerve palsies...
March 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/26173405/successful-treatment-of-dental-infection-induced-chronic-cavernous-sinus-thrombophlebitis-with-antibiotics-and-low-molecular-weight-heparin-two-case-reports
#13
Yuan Li, Bo Zheng, Kangning Chen, Li Gui
Two patients developed cavernous sinus thrombophlebitis from a tooth infection. A 36-year-old man experienced a severe headache with bilateral third and sixth cranial nerve palsies after extraction of his left upper third molar. Another 53-year-old diabetic man developed fever, headache, and bilateral complete ophthalmoplegia after a tooth infection. The brain magnetic resonance imaging scans of both patients showed bilateral cavernous sinus partial thrombosis. Broad-spectrum antibiotics plus low-molecular-weight heparin successfully resolved all symptoms...
August 2015: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/25906127/fungal-orbital-cellulitis-presenting-features-management-and-outcomes-at-a-referral-center
#14
Asim V Farooq, Rakesh M Patel, Amy Y Lin, Pete Setabutr, Juliana Sartori, Vinay K Aakalu
PURPOSE: To report a series of patients with fungal orbital cellulitis who underwent exenteration surgery and describe presenting features, management and outcomes at a referral center. METHODS: Retrospective case series. RESULTS: From November 2011 to March 2014, four patients underwent orbital exenteration for fungal orbital cellulitis at the University of Illinois. Three patients had mucormycosis and one had aspergillosis. All patients were treated with intravenous antifungals and underwent orbital exenteration...
June 2015: Orbit
https://www.readbyqxmd.com/read/25839926/endoscopic-endonasal-transsphenoidal-surgery-in-elderly-patients-with-pituitary-adenomas
#15
REVIEW
Jackson A Gondim, João Paulo Almeida, Lucas Alverne F de Albuquerque, Erika Gomes, Michele Schops, Jose Italo Mota
OBJECT: With the increase in the average life expectancy, medical care of elderly patients with symptomatic pituitary adenoma (PA) will continue to grow. Little information exists in the literature about the surgical treatment of these patients. The aim of this study was to present the results of a single pituitary center in the surgical treatment of PAs in patients > 70 years of age. METHODS: In this retrospective study, 55 consecutive elderly patients (age ≥ 70 years) with nonfunctioning PAs underwent endoscopic transsphenoidal surgery at the General Hospital of Fortaleza, Brazil, between May 2000 and December 2012...
July 2015: Journal of Neurosurgery
https://www.readbyqxmd.com/read/25660390/the-in-cis-t251i-and-p587l-polg1-base-changes-description-of-a-new-family-and-literature-review
#16
REVIEW
Carmela Scuderi, Eugenia Borgione, Filippa Castello, Mariangela Lo Giudice, Sandro Santa Paola, Mariaconcetta Giambirtone, Francesco Domenico Di Blasi, Maurizio Elia, Carmelo Amato, Santina Città, Catalda Gagliano, Giuliano Barbarino, Girolamo Aurelio Vitello, Sebastiano Antonino Musumeci
Mutations in the polymerase gamma-1 (POLG1) gene, encoding the catalytic subunit of the mtDNA-specific polymerase-γ, compromise the stability of mitochondrial DNA (mtDNA) and are responsible for numerous clinical presentations as autosomal dominant or recessive progressive external ophthalmoplegia (PEO), sensory ataxia, neuropathy, dysarthria and ophthalmoparesis (SANDO), spinocerebellar ataxia with epilepsy (SCAE) and Alpers syndrome. POLG1 mutations result in extremely heterogeneous phenotypes which often have overlapping clinical findings, making it difficult to categorize patients into syndromes, and genotype-phenotype correlations are still unclear...
April 2015: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/25045522/burkitt-s-lymphoma-presenting-with-hypopituitarism-a-case-report-and-review-of-literature
#17
Siew Hui Foo, Shahada A H Sobah
UNLABELLED: Hypopituitarism is a rare presentation of Burkitt's lymphoma (BL). The purpose of this report is to present a case of BL presenting with panhypopituitarism and to review other case reports of lymphoma presenting with pituitary dysfunction to highlight the distinguishing features of these cases from other benign aetiologies of pituitary dysfunction such as non-functioning pituitary adenomas. We reviewed a total of 11 cases of lymphoma presenting with pituitary dysfunction published from 1998 to 2013 including the present case...
2014: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/24791110/a-3-year-review-of-cranial-nerve-palsies-from-the-university-of-port-harcourt-teaching-hospital-eye-clinic-nigeria
#18
Chinyere Nnenne Pedro-Egbe, Bassey Fiebai, Elizabeth Akon Awoyesuku
PURPOSE: To provide the types, frequency and clinical information on common cranial nerve palsies seen at the Eye Clinic at the University of Port Harcourt Teaching Hospital. MATERIALS AND METHODS: A chart review was performed of patients who presented with cranial nerve palsy at the Eye Clinic over a 3-year period (January 2009-December 2011). Data were collected on age, sex, type of cranial nerve palsy, a history of systemic disease such as diabetes mellitus (DM), hypertension and cerebrovascular disease...
April 2014: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/24606795/mitochondrial-biogenesis-pharmacological-approaches
#19
EDITORIAL
Teresa Valero
Organelle biogenesis is concomitant to organelle inheritance during cell division. It is necessary that organelles double their size and divide to give rise to two identical daughter cells. Mitochondrial biogenesis occurs by growth and division of pre-existing organelles and is temporally coordinated with cell cycle events [1]. However, mitochondrial biogenesis is not only produced in association with cell division. It can be produced in response to an oxidative stimulus, to an increase in the energy requirements of the cells, to exercise training, to electrical stimulation, to hormones, during development, in certain mitochondrial diseases, etc...
2014: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/24476077/primary-treatment-regimen-and-diabetes-insipidus-as-predictors-of-health-outcomes-in-adults-with-childhood-onset-craniopharyngioma
#20
Kevin C J Yuen, Maria Kołtowska-Häggström, David M Cook, Janet L Fox, Peter J Jönsson, Mitchell E Geffner, Roger Abs
CONTEXT: Craniopharyngiomas are often associated with significant morbidity due to their location and treatment effects. Little is known of the effects of primary treatment regimen and diabetes insipidus (DI), a clinical surrogate of hypothalamic obesity, on health outcomes in adults with childhood-onset craniopharyngioma (COCP). OBJECTIVE: The objective of the study was to examine health outcomes of adults with COCP based on primary treatment regimens and the presence of DI...
April 2014: Journal of Clinical Endocrinology and Metabolism
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