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Diabetic ophthalmoplegia

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https://www.readbyqxmd.com/read/27633123/hypophyseal-metastases-a-report-of-three-cases-and-literature-review
#1
Janez Ravnik, Tomaz Smigoc, Gorazd Bunc, Bostjan Lanisnik, Ursa Ksela, Maja Ravnik, Tomaz Velnar
Metastatic tumours to the pituitary gland are rare. The most frequent are metastases from breast and lung. We describe three patients with metastatic tumours: (I) a 54-year-old patient with metastatic renal clear-cell carcinoma and consequent disturbances in visual acuity, cranial nerve paresis and panhypopituitarism, (II) a 60-year-old patient with a diffuse large B-cell lymphoma with panhypopituitarism and diabetes insipidus and (III) a 57-year-old patient with metastasis of breast cancer and panhypopituitarism, visual impairment and cranial nerve paresis...
September 4, 2016: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/27449153/assessment-of-the-prevalence-and-risk-factors-of-ophthalmoplegia-among-diabetic-patients-in-a-large-national-diabetes-registry-cohort
#2
Eman S Al Kahtani, Rajiv Khandekar, Khalid Al-Rubeaan, Amira M Youssef, Heba M Ibrahim, Ahmed H Al-Sharqawi
BACKGROUND: There are limited data on the epidemiology and risk factors of ophthalmoplegia among diabetic patients. This study aims to determine the prevalence and important risk factors related to ophthalmoplegia among diabetic patients. METHODS: This is an observational registry-based study using the Saudi National Diabetes Registry (SNDR) database to select diabetic patients regardless of their diabetes type. A total of 64,351 Saudi diabetic patients aged more than 18 years and registered in SNDR between January 2000 and December 2010 were analyzed to identify ophthalmoplegic cases...
2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27272179/acute-invasive-fungal-rhinosinusitis-our-experience-with-18-cases
#3
Mehdi Bakhshaee, Amin Bojdi, Abolghasem Allahyari, Mohammad Reza Majidi, Sherwin Tavakol, Mohammad Javad Najafzadeh, Masoud Asghari
Acute invasive fungal rhinosinusitis (AIFRS) is a rapidly progressive life threatening infection that is seen most commonly among immunocompromised patients. We present a case series of 18 patients clinically and histopathologically diagnosed with AIFRS with a mean follow-up of 9.11 ± 2.51 months (range 6-17). Demographic data, apparent symptoms and signs, underlying disorders, and outcomes are discussed. The mean age was 39.56 ± 20.66 years (range 2-75). The most common underlying diseases were diabetes mellitus (50 %) and leukemia (44...
June 7, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27256997/lethargy-and-vision-loss-successful-management-of-rhinocerebral-mucormycosis
#4
Ramzi Mulki, Muhammad Masab, Glenn Eiger, Sarah Perloff
Rhinocerebral mucormycosis (RCM) is an angioinvasive fungal infection most often caused by Rhizopus oryzae It is usually associated with an underlying risk factor and is associated with a poor prognosis. There are no consensus guidelines on the optimal management of this aggressive disease; most management decisions are based on case reports and expert opinion. We report a successfully managed case of RCM in an insulin-dependent diabetic, initially presenting with a change in mental status, rapidly progressing to complete right eye blindness and ophthalmoplegia and complicated by multiple cerebral infarctions and abscesses...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/26297877/the-pescatorial-sixth
#5
Francesco Pellegrini, Giovanni Prosdocimo, Jason J S Barton
A 56-year-old man with diabetes presented with acute diplopia and signs of bilateral complete abduction deficits. Diffuse areflexia was his only other sign at presentation. Within a few days, he developed complete ophthalmoplegia and ataxia, consistent with a clinical diagnosis of Miller-Fisher syndrome, and repeated history revealed a possible gastroenteritis 3 weeks prior. This case illustrates an "ophthalmoplegia without ataxia" variant of this classic autoimmune condition, which should be considered in patients presenting with bilateral VI nerve palsies...
March 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/26173405/successful-treatment-of-dental-infection-induced-chronic-cavernous-sinus-thrombophlebitis-with-antibiotics-and-low-molecular-weight-heparin-two-case-reports
#6
Yuan Li, Bo Zheng, Kangning Chen, Li Gui
Two patients developed cavernous sinus thrombophlebitis from a tooth infection. A 36-year-old man experienced a severe headache with bilateral third and sixth cranial nerve palsies after extraction of his left upper third molar. Another 53-year-old diabetic man developed fever, headache, and bilateral complete ophthalmoplegia after a tooth infection. The brain magnetic resonance imaging scans of both patients showed bilateral cavernous sinus partial thrombosis. Broad-spectrum antibiotics plus low-molecular-weight heparin successfully resolved all symptoms...
August 2015: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/25906127/fungal-orbital-cellulitis-presenting-features-management-and-outcomes-at-a-referral-center
#7
Asim V Farooq, Rakesh M Patel, Amy Y Lin, Pete Setabutr, Juliana Sartori, Vinay K Aakalu
PURPOSE: To report a series of patients with fungal orbital cellulitis who underwent exenteration surgery and describe presenting features, management and outcomes at a referral center. METHODS: Retrospective case series. RESULTS: From November 2011 to March 2014, four patients underwent orbital exenteration for fungal orbital cellulitis at the University of Illinois. Three patients had mucormycosis and one had aspergillosis. All patients were treated with intravenous antifungals and underwent orbital exenteration...
June 2015: Orbit
https://www.readbyqxmd.com/read/25839926/endoscopic-endonasal-transsphenoidal-surgery-in-elderly-patients-with-pituitary-adenomas
#8
REVIEW
Jackson A Gondim, João Paulo Almeida, Lucas Alverne F de Albuquerque, Erika Gomes, Michele Schops, Jose Italo Mota
OBJECT: With the increase in the average life expectancy, medical care of elderly patients with symptomatic pituitary adenoma (PA) will continue to grow. Little information exists in the literature about the surgical treatment of these patients. The aim of this study was to present the results of a single pituitary center in the surgical treatment of PAs in patients > 70 years of age. METHODS: In this retrospective study, 55 consecutive elderly patients (age ≥ 70 years) with nonfunctioning PAs underwent endoscopic transsphenoidal surgery at the General Hospital of Fortaleza, Brazil, between May 2000 and December 2012...
July 2015: Journal of Neurosurgery
https://www.readbyqxmd.com/read/25660390/the-in-cis-t251i-and-p587l-polg1-base-changes-description-of-a-new-family-and-literature-review
#9
REVIEW
Carmela Scuderi, Eugenia Borgione, Filippa Castello, Mariangela Lo Giudice, Sandro Santa Paola, Mariaconcetta Giambirtone, Francesco Domenico Di Blasi, Maurizio Elia, Carmelo Amato, Santina Città, Catalda Gagliano, Giuliano Barbarino, Girolamo Aurelio Vitello, Sebastiano Antonino Musumeci
Mutations in the polymerase gamma-1 (POLG1) gene, encoding the catalytic subunit of the mtDNA-specific polymerase-γ, compromise the stability of mitochondrial DNA (mtDNA) and are responsible for numerous clinical presentations as autosomal dominant or recessive progressive external ophthalmoplegia (PEO), sensory ataxia, neuropathy, dysarthria and ophthalmoparesis (SANDO), spinocerebellar ataxia with epilepsy (SCAE) and Alpers syndrome. POLG1 mutations result in extremely heterogeneous phenotypes which often have overlapping clinical findings, making it difficult to categorize patients into syndromes, and genotype-phenotype correlations are still unclear...
April 2015: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/25045522/burkitt-s-lymphoma-presenting-with-hypopituitarism-a-case-report-and-review-of-literature
#10
Siew Hui Foo, Shahada A H Sobah
UNLABELLED: Hypopituitarism is a rare presentation of Burkitt's lymphoma (BL). The purpose of this report is to present a case of BL presenting with panhypopituitarism and to review other case reports of lymphoma presenting with pituitary dysfunction to highlight the distinguishing features of these cases from other benign aetiologies of pituitary dysfunction such as non-functioning pituitary adenomas. We reviewed a total of 11 cases of lymphoma presenting with pituitary dysfunction published from 1998 to 2013 including the present case...
2014: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/24791110/a-3-year-review-of-cranial-nerve-palsies-from-the-university-of-port-harcourt-teaching-hospital-eye-clinic-nigeria
#11
Chinyere Nnenne Pedro-Egbe, Bassey Fiebai, Elizabeth Akon Awoyesuku
PURPOSE: To provide the types, frequency and clinical information on common cranial nerve palsies seen at the Eye Clinic at the University of Port Harcourt Teaching Hospital. MATERIALS AND METHODS: A chart review was performed of patients who presented with cranial nerve palsy at the Eye Clinic over a 3-year period (January 2009-December 2011). Data were collected on age, sex, type of cranial nerve palsy, a history of systemic disease such as diabetes mellitus (DM), hypertension and cerebrovascular disease...
April 2014: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/24606795/mitochondrial-biogenesis-pharmacological-approaches
#12
EDITORIAL
Teresa Valero
Organelle biogenesis is concomitant to organelle inheritance during cell division. It is necessary that organelles double their size and divide to give rise to two identical daughter cells. Mitochondrial biogenesis occurs by growth and division of pre-existing organelles and is temporally coordinated with cell cycle events [1]. However, mitochondrial biogenesis is not only produced in association with cell division. It can be produced in response to an oxidative stimulus, to an increase in the energy requirements of the cells, to exercise training, to electrical stimulation, to hormones, during development, in certain mitochondrial diseases, etc...
2014: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/24476077/primary-treatment-regimen-and-diabetes-insipidus-as-predictors-of-health-outcomes-in-adults-with-childhood-onset-craniopharyngioma
#13
Kevin C J Yuen, Maria Kołtowska-Häggström, David M Cook, Janet L Fox, Peter J Jönsson, Mitchell E Geffner, Roger Abs
CONTEXT: Craniopharyngiomas are often associated with significant morbidity due to their location and treatment effects. Little is known of the effects of primary treatment regimen and diabetes insipidus (DI), a clinical surrogate of hypothalamic obesity, on health outcomes in adults with childhood-onset craniopharyngioma (COCP). OBJECTIVE: The objective of the study was to examine health outcomes of adults with COCP based on primary treatment regimens and the presence of DI...
April 2014: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/24400984/painful-ophthalmoplegia-with-normal-cranial-imaging
#14
Chih-Hsien Hung, Kuo-Hsuan Chang, Chun-Che Chu, Ming-Feng Liao, Hong-Shiu Chang, Rong-Kuo Lyu, Yi-Ming Wu, Yao-Liang Chen, Chiou-Lian Lai, Hsiao-Jung Tseng, Long-Sun Ro
BACKGROUND: Painful ophthalmoplegia with normal cranial imaging is rare and confined to limited etiologies. In this study, we aimed to elucidate these causes by evaluating clinical presentations and treatment responses. METHODS: Cases of painful ophthalmoplegia with normal cranial MRI at a single center between January 2001 and June 2011 were retrospectively reviewed. Diagnoses of painful ophthalmoplegia were made according to the recommendations of the International Headache Society...
2014: BMC Neurology
https://www.readbyqxmd.com/read/24375076/the-m-3243a-g-mitochondrial-dna-mutation-and-related-phenotypes-a-matter-of-gender
#15
Michelangelo Mancuso, Daniele Orsucci, Corrado Angelini, Enrico Bertini, Valerio Carelli, Giacomo Pietro Comi, Alice Donati, Carlo Minetti, Maurizio Moggio, Tiziana Mongini, Serenella Servidei, Paola Tonin, Antonio Toscano, Graziella Uziel, Claudio Bruno, Elena Caldarazzo Ienco, Massimiliano Filosto, Costanza Lamperti, Michela Catteruccia, Isabella Moroni, Olimpia Musumeci, Elena Pegoraro, Dario Ronchi, Filippo Maria Santorelli, Donato Sauchelli, Mauro Scarpelli, Monica Sciacco, Maria Lucia Valentino, Liliana Vercelli, Massimo Zeviani, Gabriele Siciliano
The m.3243A>G "MELAS" (mitochondrial encephalopathy with lactic acidosis and stroke-like episodes) mutation is one of the most common point mutations of the mitochondrial DNA, but its phenotypic variability is incompletely understood. The aim of this study was to revise the phenotypic spectrum associated with the mitochondrial m.3243A>G mutation in 126 Italian carriers of the mutation, by a retrospective, database-based study ("Nation-wide Italian Collaborative Network of Mitochondrial Diseases"). Our results confirmed the high clinical heterogeneity of the m...
March 2014: Journal of Neurology
https://www.readbyqxmd.com/read/24371499/orbital-complications-of-fungal-pan-sinusitis-in-uncontrolled-diabetes
#16
Miruna Nicolae, Cristian Radu Popescu, Bogdan Popescu, Raluca Grigore
The purpose of our clinical case presentation is to emphasize the role of ear, nose and throat specialist in early recognition and urgent treatment of mucormycosis, which is a rare infection caused by fungus belonging to the order Mucorales. They are known opportunistic organisms, which potentially invade and infect a host with depressed immunity. In our paper we present a case of an uncontrolled diabetic male with orbital complications caused by a fungal pan-sinusitis. The typical presentation of rhino-orbital fungal infection is that of anterior orbital inflammation, severe visual loss, external ophthalmoplegia and fever...
September 2013: Mædica
https://www.readbyqxmd.com/read/24366704/sphenoid-sinus-mucocele-as-a-cause-of-isolated-pupil-sparing-oculomotor-nerve-palsy-mimicking-diabetic-ophthalmoplegia
#17
Alireza Mohebbi, Hesam Jahandideh, Ali Amini Harandi
A 37-year-old woman presented with isolated right-sided oculomotor nerve palsy. Neurologic examination revealed no other disorder. Computed tomography of the paranasal sinuses demonstrated complete opacification of the sphenoid sinus. Dense mucoid fluid was drained from the sphenoid sinus via an endoscopic transseptal sphenoidotomy. A biopsy confirmed the diagnosis of sphenoid sinus mucocele. At follow-up 4 weeks postoperatively, the patient's ocular symptoms were markedly alleviated. Considering rare causes of isolated oculomotor nerve palsy, such as sphenoid sinus mucocele, is important in the differential diagnosis, even in patients with well-known risk factors such as diabetes mellitus...
December 2013: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/24353740/an-85-year-old-woman-with-miller-fisher-syndrome
#18
Shu-Hui Wang, Yong-Bo Zhang, Yan-Chen Xie, De-Xin Wang, Ji-Mei Li
Miller Fisher's syndrome (MFS) commonly presents in the fourth and fifth decades and are rare in people over 70 years. An 85-year-old female with no significant medical history presented with upper extremity anesthesia, ptosis, and unsteady gait. The patient had a history of hypertension and diabetes mellitus. Physical examination showed bilateral total external ophthalmoplegia, areflexia, and cerebellar ataxia. Radiological and laboratory studies were unremarkable. Lumbar puncture showed albuminocytological dissociation...
September 2013: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/24283827/magnetic-resonance-imaging-in-a-case-of-migraine-with-ophthalmoplegia
#19
I Aers, M Van Zandijcke, I Dehaene, J Casselman
We present the case of a migrainous girl who suffered an episode of migraine-like headache associated with ophthalmoplegia. MRI showed reversible enhancement and thickening of the cisternal portion of the oculomotor nerve. This finding suggests a mechanism different from diabetic ischaemic neuropathy, as similar MRI abnormalities were rarely reported in diabetic ophthalmoplegia. The MRI findings are most in favour of an inflammatory cause.
January 1997: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/23999535/a-rare-case-of-complete-bilateral-ophthalmoplegia-and-ptosis
#20
Daniel John Hall, Talal Bazaraa
We describe the case of an 85-year-old gentleman admitted with bilateral ptosis and complete bilateral ocular paralysis. Initial differential diagnoses included myasthenia gravis, diabetic cranial neuropathy, an ischaemic event and possible occult neoplasm. Investigations did not support any of the differentials and Miller Fisher syndrome (MFS) was considered. Anti-GQ1b IgG antibody was positive, supporting the possibility of anti-ganglioside syndrome. This gentleman was treated with intravenous immunoglobulin (IVIG) and made a full recovery...
January 2014: Age and Ageing
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