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https://www.readbyqxmd.com/read/27376823/sarcopenia-in-critically-ill-patients
#1
REVIEW
Muhammet C Kizilarslanoglu, Mehmet E Kuyumcu, Yusuf Yesil, Meltem Halil
Sarcopenia occurring as a primary consequence of aging and secondary due to certain medical problems including chronic disease, malnutrition and inactivity is a progressive generalized loss of skeletal muscle mass, strength and function. The prevalence of sarcopenia increases with aging (approximately 5-13 % in the sixth and seventh decades). However, data showing the prevalence and clinical outcomes of sarcopenia in intensive care units (ICUs) are limited. A similar condition to sarcopenia in the ICU, called ICU-acquired weakness (ICU-AW), has been reported more frequently...
October 2016: Journal of Anesthesia
https://www.readbyqxmd.com/read/27193340/muscle-regeneration-after-sepsis
#2
Adrien Bouglé, Pierre Rocheteau, Tarek Sharshar, Fabrice Chrétien
Severe critical illness is often complicated by intensive care unit-acquired weakness (ICU-AW), which is associated with increased ICU and post-ICU mortality, delayed weaning from mechanical ventilation and long-term functional disability. Several mechanisms have been implicated in the pathophysiology of ICU-AW, but muscle regeneration has not been investigated to any extent in this context, even though its involvement is suggested by the protracted functional consequences of ICU-AW. Recent data suggest that muscle regeneration could be impaired after sepsis, and that mesenchymal stem cell treatment could improve the post-injury muscle recovery...
May 19, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27030815/dysfunction-of-respiratory-muscles-in-critically-ill-patients-on-the-intensive-care-unit
#3
REVIEW
David Berger, Stefan Bloechlinger, Stephan von Haehling, Wolfram Doehner, Jukka Takala, Werner J Z'Graggen, Joerg C Schefold
Muscular weakness and muscle wasting may often be observed in critically ill patients on intensive care units (ICUs) and may present as failure to wean from mechanical ventilation. Importantly, mounting data demonstrate that mechanical ventilation itself may induce progressive dysfunction of the main respiratory muscle, i.e. the diaphragm. The respective condition was termed 'ventilator-induced diaphragmatic dysfunction' (VIDD) and should be distinguished from peripheral muscular weakness as observed in 'ICU-acquired weakness (ICU-AW)'...
September 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/26336483/veno-venous-extracorporeal-membrane-oxygenation-in-a-patient-with-severe-acute-respiratory-failure-case-report
#4
Bartosz Kubisa, Paweł Łukasz Dec, Anna Justyna Lesińska, Anna Bocheńska, Piotr Wasilewski, Grzegorz Feldyk, Anna Kubisa, Jarosław Pieróg, Michał Bielewicz, Tomasz Grodzki
Acute respiratory failure resistant to conventional pulmonary therapy often requires intensive medical care. In rare cases, ventilator therapy proves insufficient, and only the option of employing veno-venous extracorporeal membrane oxygenation (ECMO V-V) remains. The present article describes the case of a 23-year-old patient who experienced severe acute respiratory distress syndrome with associated multiple organ failure. The patient was admitted to the pulmonary ward of the Alfred Sokołowski Regional Pulmonary Hospital in Szczecin-Zdunowo with suspected pneumonia of unknown etiology...
March 2015: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/26336482/penetrating-thoracic-injuries-treatment-of-two-patients-after-suicide-attempts
#5
Krzysztof Greberski, Paweł Bugajski, Stanisław Rzymski, Radosław Jarząbek, Bogumił Olczak, Ryszard Kalawski
Thoracic injuries are usually caused by penetrating or blunt trauma. The primary method of treatment is surgery. This study describes two cases of male patients with stab wounds of the chest resulting from suicide attempts. The first case involved a 29-year-old patient transported and admitted to the hospital with a knife still in his chest; its blade extended from the jugular notch to the 5(th) thoracic vertebra but did not damage any important structures. The applied treatment, limited to evacuating the knife, resulted in a satisfactory outcome, and the patient was discharged from the intensive care unit (ICU) in good condition...
March 2015: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/26212171/combining-nutrition-and-exercise-to-optimize-survival-and-recovery-from-critical-illness-conceptual-and-methodological-issues
#6
Daren K Heyland, Renee D Stapleton, Marina Mourtzakis, Catherine L Hough, Peter Morris, Nicolaas E Deutz, Elizabeth Colantuoni, Andrew Day, Carla M Prado, Dale M Needham
Survivors of critical illness commonly experience neuromuscular abnormalities, including muscle weakness known as ICU-acquired weakness (ICU-AW). ICU-AW is associated with delayed weaning from mechanical ventilation, extended ICU and hospital stays, more healthcare-related hospital costs, a higher risk of death, and impaired physical functioning and quality of life in the months after ICU admission. These observations speak to the importance of developing new strategies to aid in the physical recovery of acute respiratory failure patients...
October 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/26165240/penetrating-brain-injury-a-case-report
#7
Katarzyna Śmiłowska, Justyna Pytel, Lech Krawczyk, Marek Śmiłowski, Przemysław Jałowiecki
BACKGROUND: Gunshot wounds as a result of attempted suicide, criminality or warfare comprise a significant group among penetrating injuries of the brain. A prognosis in such cases is based mainly on an initial score on the Glasgow Coma Scale (GCS). According to the literature, the mortality rate among patients with initial GCS ranging from 3 to 5 points is very high, up to 98.5%. Although there are also many other prognostic factors for high mortality, such as damage to the ventricular system or the involvement of two or more lobes, GCS score seems to be the most important determinant...
2015: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/26044880/quantitative-neuromuscular-ultrasound-in-intensive-care-unit-acquired-weakness-a-systematic-review
#8
REVIEW
Aaron Bunnell, John Ney, Alfred Gellhorn, Catherine L Hough
Intensive care unit-acquired weakness (ICU-AW) causes significant morbidity and impairment in critically ill patients. Recent advances in neuromuscular ultrasound (NMUS) allow evaluation of neuromuscular pathology early in critical illness. Here we review application of ultrasound in ICU-AW. MEDLINE-indexed articles were searched for terms relevant to ultrasound and critical illness. Two reviewers evaluated the resulting abstracts (n = 218) and completed full-text review (n = 13). Twelve studies and 1 case report were included...
November 2015: Muscle & Nerve
https://www.readbyqxmd.com/read/26015329/assessment-of-intensive-care-unit-acquired-weakness-in-young-and-old-mice-an-e-coli-septic-peritonitis-model
#9
Esther Witteveen, Inge C M Hoogland, Luuk Wieske, Nina C Weber, Camiel Verhamme, Marcus J Schultz, Ivo N van Schaik, Janneke Horn
INTRODUCTION: There are few reports of in vivo muscle strength measurements in animal models of ICU-acquired weakness (ICU-AW). In this study we investigated whether the Escherichia coli (E. coli) septic peritonitis mouse model may serve as an ICU-AW model using in vivo strength measurements and myosin/actin assays, and whether development of ICU-AW is age-dependent in this model. METHODS: Young and old mice were injected intraperitoneally with E. coli and treated with ceftriaxone...
January 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/25928709/impact-of-icu-acquired-weakness-on-post-icu-physical-functioning-a-follow-up-study
#10
Luuk Wieske, Daniela S Dettling-Ihnenfeldt, Camiel Verhamme, Frans Nollet, Ivo N van Schaik, Marcus J Schultz, Janneke Horn, Marike van der Schaaf
INTRODUCTION: ICU-acquired weakness is thought to mediate physical impairments in survivors of critical illness, but few studies have investigated this thoroughly. The purpose was to investigate differences in post-ICU mortality and physical functioning between patients with and without ICU-acquired weakness at 6 months after ICU discharge. METHOD: ICU patients, mechanically ventilated ≥ 2 days, were included in a single-center prospective observational cohort study...
2015: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/25882719/a-new-two-tier-strength-assessment-approach-to-the-diagnosis-of-weakness-in-intensive-care-an-observational-study
#11
Selina M Parry, Sue Berney, Catherine L Granger, Danielle L Dunlop, Laura Murphy, Doa El-Ansary, René Koopman, Linda Denehy
INTRODUCTION: Intensive care unit-acquired weakness (ICU-AW) is a significant problem. There is currently widespread variability in the methods used for manual muscle testing and handgrip dynamometry (HGD) to diagnose ICU-AW. This study was conducted in two parts. The aims of this study were: to determine the inter-rater reliability and agreement of manual muscle strength testing using both isometric and through-range techniques using the Medical Research Council sum score and a new four-point scale, and to examine the validity of HGD and determine a cutoff score for the diagnosis of ICU-AW for the new four-point scale...
February 26, 2015: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/25777875/a-new-two-tier-strength-assessment-approach-to-the-diagnosis-of-weakness-in-intensive-care-an-observational-study
#12
Selina M Parry, Sue Berney, Catherine L Granger, Danielle L Dunlop, Laura Murphy, Doa El-Ansary, René Koopman, Linda Denehy
INTRODUCTION: Intensive care unit-acquired weakness (ICU-AW) is a significant problem. There is currently widespread variability in the methods used for manual muscle testing and handgrip dynamometry (HGD) to diagnose ICU-AW. This study was conducted in two parts. The aims of this study were: to determine the inter-rater reliability and agreement of manual muscle strength testing using both isometric and through-range techniques using the Medical Research Council sum score and a new four-point scale, and to examine the validity of HGD and determine a cutoff score for the diagnosis of ICU-AW for the new four-point scale...
December 2015: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/25772830/the-differences-between-two-selected-intensive-care-units-located-in-central-and-northern-europe-preliminary-observation
#13
Jan Adamski, Radosław Goraj, Dariusz Onichimowski, Ewa Gawlikowska, Wojciech Weigl
BACKGROUND: The aim of this study was to evaluate possible differences in the functioning of two selected intensive care units in Poland and Finland. The activity of the units was analysed over a period of one year. METHODS: The following parameters were compared: demography of treated populations, site of admission, category of illness, severity of illness (APACHE-II scale), mean length of stay, demanded workload (TISS-28 scale), mortality (both ICU and hospital) and standardized mortality ratio (SMR)...
2015: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/25703957/exercise-based-rehabilitation-after-hospital-discharge-for-survivors-of-critical-illness-with-intensive-care-unit-acquired-weakness-a-pilot-feasibility-trial
#14
RANDOMIZED CONTROLLED TRIAL
Bronwen Connolly, April Thompson, Abdel Douiri, John Moxham, Nicholas Hart
PURPOSE: The aim of this study was to investigate feasibility of exercise-based rehabilitation delivered after hospital discharge in patients with intensive care unit-acquired weakness (ICU-AW). MATERIALS AND METHODS: Twenty adult patients, mechanically ventilated for more than 48 hours, with ICU-AW diagnosis at ICU discharge were included in a pilot feasibility randomized controlled trial receiving a 16-session exercise-based rehabilitation program. Twenty-one patients without ICU-AW participated in a nested observational cohort study...
June 2015: Journal of Critical Care
https://www.readbyqxmd.com/read/25618110/esbl-producing-escherichia-coli-isolated-from-bloodstream-infections-antimicrobial-susceptibility-conjugative-transfer-of-resistance-genes-and-phylogenetic-origin
#15
Roman Franiczek, Barbara Krzyżanowska
BACKGROUND: The prevalence of bloodstream infections (BSIs) due to ESBL-producing Escherichia coli (ESBL-EC) strains has increased dramatically over the past years. OBJECTIVES: Characterization of ESBL-EC isolates collected from BSIs with regard to their antimicrobial susceptibility and phylogenetic background. The conjugative transfer of resistance determinants to the E. coli reference strain K12 C600 was also investigated. MATERIAL AND METHODS: A collection of forty-eight ESBL-EC strains recovered from BSIs was subjected to the study...
November 2014: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/25610047/clinical-implications-of-chest-x-ray-parameters-in-evaluating-patients-with-cardiac-dyspnea
#16
Elif Torun, Fehmi Kacmaz
OBJECTIVE: To evaluate the relationship between aortic arch calcification and clinical and radiographical parameters on chest radiography. MATERIALS AND METHODS: We retrospectively evaluated 242 consecutive patients that were admitted to our intensive care unit for dyspnea. Chest radiography was performed for all patients with the posteroanterior view. Cardiothoracic ratio (CTR), mediastinal ratio (MR), aortic width (AW) parameters and the grade of aortic calcification were recorded...
December 2008: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/25603227/muscle-weakness-and-nutrition-therapy-in-icu
#17
REVIEW
Michael P Casaer
PURPOSE OF REVIEW: Muscle wasting is common in severe critical illness. ICU-acquired weakness (ICU-AW) contributes to acute and long-term morbidity and mortality. The question remains whether nutrition therapy in ICU can prevent or attenuate these complications. This review aims at integrating the most recent clinical data in order to answer this important clinical and research question. Clinical evidence was obtained from randomized controlled trials (RCTs). Results from animal experiments and observational studies are referred to when - respectively - providing possible explanatory mechanisms or new hypotheses...
March 2015: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/25491702/mechanical-ventilation-in-children-problems-and-issues
#18
Marzena Zielińska, Stanisław Zieliński, Alicja Sniatkowska-Bartkowska
Respiratory failure is the leading reason for the admission of children to intensive care units, and the ventilator is the main therapeutic tool used during the treatment of these patients. A competently used ventilator and adequate knowledge of the anatomy, histology and physiology of the respiratory system in particular age groups of children (especially among neonates and infants) are crucial for successful treatment. Both non-invasive and invasive ventilation modes can be used for respiratory treatment in children...
September 2014: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/25403763/feasibility-and-diagnostic-accuracy-of-early-electrophysiological-recordings-for-icu-acquired-weakness-an-observational-cohort-study
#19
Luuk Wieske, Camiel Verhamme, Esther Witteveen, Aline Bouwes, Daniela S Dettling-Ihnenfeldt, Marike van der Schaaf, Marcus J Schultz, Ivo N van Schaik, Janneke Horn
BACKGROUND: An early diagnosis of ICU-acquired weakness (ICU-AW) is difficult because disorders of consciousness frequently preclude muscle strength assessment. In this study, we investigated feasibility and accuracy of electrophysiological recordings to diagnose ICU-AW early in non-awake critically ill patients. METHODS: Newly admitted patients, mechanically ventilated ≥2 days and unreactive to verbal stimuli, were included in this study. Electrophysiological recordings comprised nerve conduction studies (NCS) of three nerves and, if coagulation was normal, myography in three muscles...
June 2015: Neurocritical Care
https://www.readbyqxmd.com/read/25382987/evaluating-the-effects-of-dexmedetomidine-compared-to-propofol-as-adjunctive-therapy-in-patients-with-alcohol-withdrawal
#20
Riley J Lizotte, John A Kappes, Billie J Bartel, Katie M Hayes, Veronica L Lesselyoung
BACKGROUND: In severe alcohol withdrawal (AW), benzodiazepines may be inadequate to control symptoms. In many situations, benzodiazepine dosing escalates despite no additional efficacy and introduces potential toxicities. Severe cases of AW may require additional agents to control symptoms. Case reports and studies have shown benefits with dexmedetomidine and propofol in severe AW, but these agents have not been compared with one another. This study compares the effects of dexmedetomidine and propofol on benzodiazepine and haloperidol utilization in patients with AW...
2014: Clinical Pharmacology: Advances and Applications
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