Chao Li, Qiu-Ying Ma, Xue-Qi Liu, Hai-di Li, Ming-Jun Yu, Shuai-Shuai Xie, Wen-Xian Ma, Ying Chen, Jia-Nan Wang, Ruo-Bing He, He-Ge Bian, Yuan He, Li Gao, Sheng-Song Deng, Hong-Mei Zang, Qian Gong, Jia-Gen Wen, Ming-Ming Liu, Chen Yang, Hai-Yong Chen, Jun Li, Hui-Yao Lan, Juan Jin, Ri-Sheng Yao, Xiao-Ming Meng
Gastrin-releasing peptide (GRP) binds to its receptor GRPR to regulate multiple biological processes, but the function of GRP/GRPR axis in acute kidney injury (AKI) remains unknown. In the present study, GRPR is highly expressed by tubular epithelial cells (TECs) in patients or mice with AKI. While histone deacetylase 8 may lead to the transcriptional activation of GRPR. Functionally, we uncovered that GRPR was pathogenic in AKI as genetic deletion of GRPR was able to protect mice from cisplatin and ischemic induced AKI...
July 5, 2023: Molecular Therapy