keyword
MENU ▼
Read by QxMD icon Read
search

IL-21

keyword
https://www.readbyqxmd.com/read/28731149/the-role-of-t-helper-17-cells-in-the-pathogenesis-of-hepatitis-b-virus-related-liver-cirrhosis-review
#1
Suxia Bao, Jianming Zheng, Guangfeng Shi
In chronic hepatitis B virus (HBV)-infected patients, T helper 17 (Th17) cells are significantly elevated. Th17 cells initiate immune‑mediated pathogenesis and have a critical role in the process of HBV‑related liver cirrhosis (HBV‑LC). The mechanisms underlying this process are attributed to Th17‑secreted cytokines, which include interleukin (IL)‑17, IL‑21 and IL‑22; however, a systemic analysis regarding these mechanisms has yet to be conducted. Therefore, the present study aimed to investigate the role of Th17 cells in the pathogenesis of HBV‑LC...
July 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28728856/achaete-scute-complex-homologue-2-accelerates-the-development-of-sj%C3%A3-gren-s-syndrome-like-disease-in-the-nod-shiltj-mouse
#2
Sung-Min Kim, Jeong-Eun Kwon, Jin-Sil Park, Hyeon-Beom Seo, Kyung-Ah Jung, Young-Mee Moon, Jennifer Lee, Seung-Ki Kwok, Mi-La Cho, Sung-Hwan Park
Achaete-scute complex homologue 2 (Ascl2) has been reported to induce the differentiation and activation of follicular helper T (TFH) cells, which are essential for development of Sjögren's syndrome (SS). This study examined whether Ascl2 plays a role in the development of SS. NOD/ShiLtJ mice were injected with an Ascl2-overexpression vector, and the infiltration of lymphocytes into salivary and lacrimal glands was assessed. The expression of inflammatory cytokines and chemoattractants for T or B cells was measured...
July 17, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28727987/associations-of-autoimmunity-immunodeficiency-lymphomagenesis-and-gut-microbiota-in-mice-with-knockins-for-a-pathogenic-autoantibody
#3
Shweta Jain, Jerrold M Ward, Dong-Mi Shin, Hongsheng Wang, Zohreh Naghashfar, Alexander L Kovalchuk, Herbert C Morse
A number of mouse strains transgenic for B-cell receptors specific for nucleic acids or other autoantigens have been generated to understand how autoreactive B cells are regulated in normal and autoimmune mice. Previous studies of nonautoimmune C57BL/6 mice heterozygous for both the IgH and IgL knockins of the polyreactive autoantibody, 564, produced high levels of autoantibodies in a largely Toll-like receptor 7-dependent manner. Herein, we describe studies of mice homozygous for the knockins that also expressed high levels of autoantibodies but, unlike the heterozygotes, exhibited a high incidence of mature B-cell lymphomas and enhanced susceptibility to bacterial infections...
July 17, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28713386/impairment-of-granzyme-b-producing-regulatory-b-cells-correlates-with-exacerbated-rheumatoid-arthritis
#4
Liling Xu, Xu Liu, Hongjiang Liu, Lei Zhu, Huaqun Zhu, Jian Zhang, Limin Ren, Pingzhang Wang, Fanlei Hu, Yin Su
Hyperactivated B cells have been demonstrated the contribution to the development of rheumatoid arthritis (RA). While the recognition of the negative regulatory function of B cells further promoted our understanding of their pathogenic role in RA. Recently, a new population of granzyme B (GrB)-producing B cells was identified, which was proved to be involved in cancer and infectious diseases. However, their characteristics and roles in RA remain to be elucidated. In the present study, we aim to further characterize whether B cells could produce GrB and reveal their potential role in the pathogenesis of RA...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28711285/anti-il-21-monoclonal-antibody-combined-with-liraglutide-effectively-reverses-established-hyperglycemia-in-mouse-models-of-type-1-diabetes
#5
Anna K Rydén, Nikole R Perdue, Philippe P Pagni, Claire B Gibson, Sowbarnika S Ratliff, Rikke K Kirk, Travis J Friesen, Claus Haase, Ken Coppieters, Matthias G von Herrath, Tamar E Boursalian
Immunotherapy for type 1 diabetes (T1D) has previously focused on suppressing the autoimmune response against pancreatic beta cells to preserve endogenous insulin production and regulate glucose levels. With increased attention toward combination therapy strategies, studies indicate the multifunctional cytokine interleukin-21 (IL-21) may be a suitable target as an immuno-modulatory arm, while glucagon-like peptide-1 receptor (GLP-1R) agonists may be appropriate as a beta cell protective arm in combination therapy for T1D...
July 12, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28708900/serum-levels-of-interleukin-6-are-linked-to-the-severity-of-the-disease-caused-by-andes-virus
#6
Jenniffer Angulo, Constanza Martínez-Valdebenito, Claudia Marco, Héctor Galeno, Eliecer Villagra, Lilian Vera, Natalia Lagos, Natalia Becerra, Judith Mora, Andrea Bermúdez, Janepsy Díaz, Marcela Ferrés, Marcelo López-Lastra
Andes virus (ANDV) is the etiological agent of hantavirus cardiopulmonary syndrome in Chile. In this study, we evaluated the profile of the pro-inflammatory cytokines IL-1β, IL-12p70, IL-21, TNF-α, IFN-γ, IL-10 and IL-6 in serum samples of ANDV-infected patients at the time of hospitalization. The mean levels of circulating cytokines were determined by a Bead-Based Multiplex assay coupled with Luminex detection technology, in order to compare 43 serum samples of healthy controls and 43 samples of ANDV-infected patients that had been categorized according to the severity of disease...
July 14, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28700710/t-follicular-helper-cells-regulate-the-activation-of-b-lymphocytes-and-antibody-production-during-plasmodium-vivax-infection
#7
Maria Marta Figueiredo, Pedro Augusto Carvalho Costa, Suelen Queiroz Diniz, Priscilla Miranda Henriques, Flora Satiko Kano, Mauro Sugiro Tada, Dhelio Batista Pereira, Irene Silva Soares, Olindo Assis Martins-Filho, Dragana Jankovic, Ricardo Tostes Gazzinelli, Lis Ribeiro do Valle Antonelli
Although the importance of humoral immunity to malaria has been established, factors that control antibody production are poorly understood. Follicular helper T cells (Tfh cells) are pivotal for generating high-affinity, long-lived antibody responses. While it has been proposed that expansion of antigen-specific Tfh cells, interleukin (IL) 21 production and robust germinal center formation are associated with protection against malaria in mice, whether Tfh cells are found during Plasmodium vivax (P. vivax) infection and if they play a role during disease remains unknown...
July 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28699226/ebv-provides-survival-factors-to-ebv-dlbcl-lines-and-modulates-cytokine-induced-specific-chemotaxis-in-ebv-dlbcl
#8
Liang Wu, Barbro Ehlin-Henriksson, Xiaoying Zhou, Hong Zhu, Ingemar Ernberg, Lorand L Kis, George Klein
Diffuse large B-cell lymphoma (DLBCL), the most common type of malignant lymphomas, account for 30% of adult non-Hodgkin lymphomas (NHLs). EBV-positive DLBCL of the elderly is a newly recognized subtype that accounts for 8% to 10% of DLBCL in Asian countries, but is less common in Western populations. Five DLBCL derived cell lines were employed to characterize patterns of EBV latent gene expression, as well as response to cytokines and chemotaxis. IL-4 and IL-21 modified LMP1-, EBNA1- and EBNA2-expression depending on cell phenotype and type of EBV latent program (type I, II or III)...
July 12, 2017: Immunology
https://www.readbyqxmd.com/read/28692537/early-initiation-of-antiretroviral-treatment-post-siv-infection-does-not-resolve-lymphoid-tissue-activation
#9
Jung Joo Hong, Eduardo L V Silveira, Praveen K Amancha, Siddappa N Byrareddy, Sanjeev Gumber, Kyu-Tae Chang, Aftab A Ansari, Francois Villinger
OBJECTIVE: Germinal center (GC) resident follicular helper T (TFH) cells in lymphoid follicles are a potential sanctuary for HIV/SIV replication. But the dynamics of GCs upon early initiation of antiretroviral therapy (ART) and their potential role in the formation of viral sanctuaries post SIV infection are not fully understood. DESIGN: Sequential lymph node biopsies (n = 10) were collected from SIVmac239-infected rhesus macaques before infection, at 5 weeks post infection/pre ART, 6 and 12 weeks following ART initiation...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28685820/pi3k-akt-pathway-enhances-the-differentiation-of-il-27-induced-type-1-regulatory-t-cells
#10
Niken Adiba Nadya, Hiroyuki Tezuka, Toshiaki Ohteki, Satoshi Matsuda, Miyuki Azuma, Shigenori Nagai
Interleukin 27 (IL-27) has been identified as a potent cytokine in the differentiation of type 1 regulatory T (Tr1) cells through interactions with several key elements, including transcription factors such as aryl hydrocarbon receptor and IL-21. Autocrine production of IL-21 is known to be important for maintaining IL-10 expression by Tr1 cells. Although previous studies have shown that the PI3K-Akt axis contributes to the differentiation of helper T cell subsets, the role of the PI3K pathway on Tr1 cell differentiation remains to be elucidated...
July 6, 2017: Immunology
https://www.readbyqxmd.com/read/28685527/elevated-levels-of-il-2-and-il-21-produced-by-cd4-t-cells-in-inflammatory-bowel-disease
#11
S Ebrahimpour, M Shahbazi, A Khalili, M T Tahoori, A Zavaran Hosseini, A Amari, B Aghili, S Abediankenari, H Mohammadizad, M Mohammadnia-Afrouzi
CD4+ T cells are considered as a subset of cells that play a pivotal role in the development of inflammatory bowel disease (IBD). The aim of this study was to assess the levels of interleukin (IL)-2, IL-21 and their receptors produced by CD4+ T cells in patients with inflammatory bowel disease. Thirty-two patients with ulcerative colitis (UC) and mean age of 37.93±10.37 years, as well as 22 patients with Crohn’s disease (CD) and mean age of 37.04±10.44 years, were studied. The healthy controls (HC) included 31 subjects with a mean age of 36...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28682305/ifn-%C3%AE-promotes-transendothelial-migration-of-cd4-t-cells-across-the-blood-brain-barrier
#12
Sandip Ashok Sonar, Shagufta Shaikh, Nupura Joshi, Ashwini N Atre, Girdhari Lal
Transendothelial migration (TEM) of Th1 and Th17 cells across the blood-brain barrier (BBB) plays a critical role in the development of experimental autoimmune encephalomyelitis (EAE). How cytokines produced by inflammatory Th1 and Th17 cells damage the endothelial BBB and promote transendothelial migration of immune cells into the central nervous system (CNS) during autoimmunity is not understood. We therefore investigated the effect of various cytokines on brain endothelial cells. Among the various cytokines tested, such as Th1 (IFN-γ, IL-1α, IL-1β, TNF-α, IL-12), Th2 (IL-3, IL-4, IL-6 and IL-13), Th17 (IL-17A, IL-17F, IL-21, IL-22, IL-23, GM-CSF) and Treg-specific cytokines (IL-10 and TGF-β), IFN-γ predominantly showed increased expression of ICAM-1, VCAM-1, MAdCAM-1, H2-K(b) and I-A(b) molecules on brain endothelial cells...
July 6, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28671717/the-effect-of-il-21-and-cd4-cd25-t-cells-on-cytokine-production-of-cd4-responder-t-cells-in-patients-with-myasthenia-gravis
#13
Mahdi Alahgholi-Hajibehzad, Hacer Durmuş, Fikret Aysal, Yeşim Gülşen-Parman, Piraye Oflazer, Feza Deymeer, Güher Saruhan-Direskeneli
Impairment of the suppressive function of regulatory T (Treg) cells was reported in myasthenia gravis (MG). In this study, cytokine-related mechanisms that may lead to the defect of Treg were investigated in patients with anti-acetylcholine receptor antibody positive MG (AChR+MG). Proliferation and cytokine production of responder T (Tresp) cells in response to polyclonal activation were measured in a suppression assay. The effect of IL-21 on suppression was evaluated in vitro in co-culture. IL-21 increased the proliferation of Tresp cells in Tresp/Treg co-cultures...
July 3, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28668505/regulation-of-allergic-airway-inflammation-by-adoptive-transfer-of-cd4-t-cells-preferentially-producing-il-10
#14
Masaya Matsuda, Kana Doi, Tatsuya Tsutsumi, Shinya Fujii, Maki Kishima, Kazuma Nishimura, Ikue Kuroda, Yu Tanahashi, Rino Yuasa, Toshihiko Kinjo, Nobuyuki Kuramoto, Nobuaki Mizutani, Takeshi Nabe
Anti-inflammatory pharmacotherapy for asthma has mainly depended on the inhalation of glucocorticoids, which non-specifically suppress immune responses. If the anti-inflammatory cytokine interleukin (IL)-10 can be induced by a specific antigen, asthmatic airway inflammation could be suppressed when individuals are exposed to the antigen. The purpose of this study was to develop cellular immunotherapeutics for atopic diseases using IL-10-producing CD4(+) T cells. Spleen cells isolated from ovalbumin (OVA)-sensitized mice were cultured with the antigen, OVA and growth factors, IL-21, IL-27 and TGF-β for 7 days...
June 29, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28668242/cockroach-allergen-exposure-and-plasma-cytokines-among-children-in-a-tropical-environment
#15
Brock H Medsker, Erick Forno, Yueh-Ying Han, Edna Acosta-Pérez, Angel Colón-Semidey, Maria Alvarez, John F Alcorn, Glorisa J Canino, Juan C Celedón
BACKGROUND: Little is known about the effects of socioeconomic status or cockroach allergen on immune responses in school-age children, particularly in tropical environments. OBJECTIVE: To examine whether cockroach allergen and/or socioeconomic status is associated with plasma cytokine levels in Puerto Rican children. METHODS: This was a cross-sectional study of 532 children (6-14 years old) with (n = 272) and without (n = 260) asthma in San Juan (Puerto Rico)...
July 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28665299/cytokine-mediators-of-chronic-graft-versus-host-disease
#16
Kelli Pa MacDonald, Bruce R Blazar, Geoffrey R Hill
Substantial preclinical and clinical research into chronic graft-versus-host disease (cGVHD) has come to fruition in the last five years, generating a clear understanding of a complex cytokine-driven cellular network. cGVHD is mediated by naive T cells differentiating within IL-17-secreting T cell and follicular Th cell paradigms to generate IL-21 and IL-17A, which drive pathogenic germinal center (GC) B cell reactions and monocyte-macrophage differentiation, respectively. cGVHD pathogenesis includes thymic damage, impaired antigen presentation, and a failure in IL-2-dependent Treg homeostasis...
June 30, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28659917/a-two-phase-expansion-protocol-combining-interleukin-il-15-and-il-21-improves-natural-killer-cell-proliferation-and-cytotoxicity-against-rhabdomyosarcoma
#17
Juliane Wagner, Viktoria Pfannenstiel, Anja Waldmann, Judith W J Bergs, Boris Brill, Sabine Huenecke, Thomas Klingebiel, Franz Rödel, Christian J Buchholz, Winfried S Wels, Peter Bader, Evelyn Ullrich
Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in children. Despite intensive research in recent decades the prognosis for patients with metastatic or relapsed diseases has hardly improved. New therapeutic concepts in anti-tumor therapy aim to modulate the patient's immune system to increase its aggressiveness or targeted effects toward tumor cells. Besides surgery, radiotherapy and chemotherapy, immune activation by direct application of cytokines, antibodies or adoptive cell therapy are promising approaches...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28657833/serum-interleukin-6-and-survivin-levels-predict-clinical-response-to-etanercept-treatment-in-patients-with-established-rheumatoid-arthritis
#18
Rui Shi, Muzhi Chen, Bahaerguli Litifu
OBJECTIVES: To investigate the correlation of nine potential biomarkers with clinical response to etanercept (ETN) therapy in establish rheumatoid arthritis (RA) patients. METHODS: Seventy-three patients with established RA were enrolled in the prospective cohort study. Sixty-nine of 73 cases were included into final analysis for response after 24-week ETN therapy. Serum expression of nine studied proteins was measured by enzyme-linked immunosorbent assay (ELISA)...
June 28, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28656528/chitinase-3-like-1-deficient-splenocytes-deteriorated-the-pathogenesis-of-acute-graft-versus-host-disease-via-regulating-differentiation-of-tfh-cells
#19
Zengyao Li, Hao Lu, Jian Gu, Jing Liu, Qin Zhu, Yunjie Lu, Xuehao Wang
Acute graft-versus-host disease (aGVHD) is an intractable complication in transplant patients, limiting the efficacy of this therapy. Chitinase 3-like-1 (CHI3L1), a member of the glycosyl hydrolase 18 family that lacks chitinase activity, plays a critical role in a variety of inflammatory diseases. Here, we investigated the in vitro and in vivo effects of CHI3L1 on the development of aGVHD. In this study, mixed lymphocyte reactions (MLR) in vitro showed that CHI3L1 deficiency in CD4(+) T cell promoted the production of interferon (IFN)-γ and T follicular helper (Tfh)-related cytokines such as interleukin-6 (IL-6) and interleukin-21 (IL-21)...
June 27, 2017: Inflammation
https://www.readbyqxmd.com/read/28654841/exposure-to-particulate-matter-2-5-pm2-5-induced-macrophage-dependent-inflammation-characterized-by-increased-th1-th17-cytokine-secretion-and-cytotoxicity
#20
Qin-Yun Ma, Da-Yu Huang, Hui-Jun Zhang, Shaohua Wang, Xiao-Feng Chen
Particulate matter PM2.5 is a class of airborne particles and droplets with sustained high levels in many developing countries. Epidemiological studies have shown the association between sustained high level of PM2.5 and the risk of many diseases in the respiratory system, including lung cancer. However, the precise mechanisms through which PM2.5 induces respiratory diseases are still unclear. In this study, we demonstrated that CD4(+) and CD8(+) T cells following PM2.5 treatment demonstrated significantly elevated mRNA and protein levels of interferon (IFN)-γ, interleukin (IL)-10, IL-17, and IL-21 production...
June 24, 2017: International Immunopharmacology
keyword
keyword
53327
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"