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Seeing white spots

E Santos-Bueso, A M Muñoz-Hernández, N Avalos-Franco, S García-Sáenz, F Sáenz-Francés, J Porta-Etessam
CASE REPORT: The case is presented of an 11 year-old girl referring to a one year history of photophobia and continuously seeing white spots in both eyes. The patient had a visual acuity of unity in both eyes, and a normal eye examination, and was referred to the Neuro-ophthalmology Unit. Once complete laboratory and imaging tests ruled out the possibility of any neurological pathology, she was diagnosed with visual snow (VS). DISCUSSION: VS is an isolated symptom, possibly part of the migraine aura, that is referred by patients reporting numerous and constant white dots moving in the visual field of BE...
December 2017: Archivos de la Sociedad Española de Oftalmología
Rosalia Tatano, Eva E Ehrlich, Benjamin Berkels, Ekaterina Sirazitdinova, Thomas M Deserno, Ulrike B Fritz
OBJECTIVE: Hard tooth tissue demineralisation is an undesirable side effect of orthodontic treatment with fixed appliances. Whereas both clinically and in digital photographs (DP), demineralisations appear as white spot lesions, WSLs appear as dark areas when quantitative light-induced fluorescence (QLF) imaging is used. This study aims at comparing the reproducibility of the detection of decalcified tooth areas in DP and QLF. MATERIALS AND METHODS: DP and QLF pairs were acquired from 139 teeth of 32 patients after braces removal...
March 2017: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
Sira Chuaychan, Soottawat Benjakul
Characteristics and antioxidative activity of gelatin and gelatin hydrolysate powders from scale of spotted golden goatfish using maltodextrin as a carrier agent at different ratios [1:0, 2:1, 1:1 and 1:2 (w/w)] were investigated. Gelatin hydrolysates with 40 % degree of hydrolysis exhibited the highest antioxidative activity. With increasing maltodextrin proportions, the resulting powders showed an increase in yields, total sugar content and whiteness with coincidental decrease in [Formula: see text], [Formula: see text]-values and browning intensity...
September 2016: Journal of Food Science and Technology
Dénes Száz, Alexandra Farkas, Miklós Blahó, András Barta, Ádám Egri, Balázs Kretzer, Tibor Hegedüs, Zoltán Jäger, Gábor Horváth
According to an old but still unproven theory, Viking navigators analysed the skylight polarization with dichroic cordierite or tourmaline, or birefringent calcite sunstones in cloudy/foggy weather. Combining these sunstones with their sun-dial, they could determine the position of the occluded sun, from which the geographical northern direction could be guessed. In psychophysical laboratory experiments, we studied the accuracy of the first step of this sky-polarimetric Viking navigation. We measured the adjustment error e of rotatable cordierite, tourmaline and calcite crystals when the task was to determine the direction of polarization of white light as a function of the degree of linear polarization p...
January 2016: Royal Society Open Science
Jorge Espigares, Alireza Sadr, Hidenori Hamba, Yasushi Shimada, Masayuki Otsuki, Junji Tagami, Yasunori Sumi
A technology to characterize early enamel lesions is needed in dentistry. Optical coherence tomography (OCT) is a noninvasive method that provides high-resolution cross-sectional images. The aim of this study is to compare OCT with microfocus x-ray computed tomography ([Formula: see text]) for assessment of natural enamel lesions in vitro. Ten human teeth with visible white spot-like changes on the enamel smooth surface and no cavitation (ICDAS code 2) were subjected to imaging by μCT (SMX-100CT, Shimadzu) and 1300-nm swept-source OCT (Dental SS-OCT, Panasonic Health Care)...
January 2015: Journal of Medical Imaging
Kogularamanan Suntharalingam, Anna Łęczkowska, Mona A Furrer, Yilei Wu, Marina K Kuimova, Bruno Therrien, Andrew J P White, Ramon Vilar
Hits the spot: A cyclometalled platinum(II) complex with a substituted phenanthroline ligand is reported. The complex has high in vitro affinity for quadruplex DNA and upon binding its emission is switched on. The complex can be easily delivered to the cell by using a metallo-cage as a carrier (see illustration). By means of confocal microscopy, it is shown that the complex is released inside the cell, penetrates the nucleus and localises in the nucleoli.
December 14, 2012: Chemistry: a European Journal
Richard E Glor
If island biogeography has a sweet spot, it's where islands generate their own species diversity rather than merely taking on mainland immigrants. In birds and other highly dispersive taxa, however, this 'zone of radiation', may be vanishingly small. Darwin's finches and Hawaiian Honeycreepers are among only a handful of examples of island radiation in birds (Price 2008), suggesting that winged powers of dispersal make sufficient isolation from mainland colonists unlikely, while also hindering speciation within and among isolated islands...
December 2011: Molecular Ecology
V A Runarsdottir, T Gudbjartsson, J Magnusson
INTRODUCTION: Appendicitis is a common disease, still its diagnosis can be difficult. Of resected appendices, every fifth to sixth is histologically normal. It has been suggested that local skin temperature could be helpful to diagnose appendicitis. The hypothesis was that skin temperature above an inflamed appendix was higher than elsewhere. MATERIAL AND METHODS: Patients suspected of acute appendicitis admitted to Landspitalinn University Hospital, February through June 1993, were enrolled...
June 1996: Læknablađiđ
Melinda Wenner
Biomedicine would be a breeze if organisms were transparent. With the ability to see through tissues, scientists could spot the development of tumors more easily in study animals. And biologists could study exactly how an animal's organs develop by observing them as they grow. In effect, the secrets of the body would be out there for everyone to see.The thought of peering into our tissues may sound like science fiction, but one day it could be science. Using ideas from genetics, electrical engineering, chemistry and solid-state physics, a handful of researchers are working on ways to render biological tissues transparent...
October 2009: Nature Medicine
Marc Pusey, Elizabeth Forsythe, Aniruddha Achari
Trace fluorescent labeling, typically less than 1%, can be a powerful aid in macromolecule crystallization. Precipitation concentrates a solute, and crystals are the most densely packed solid form. The more densely packed the fluorescing material, the brighter the emission from it; thus, fluorescence intensity of a solid phase is a good indication of whether or not one has crystals. The more brightly fluorescing crystalline phase is easily distinguishable, even when embedded in an amorphous precipitate. This approach conveys several distinct advantages: one can see what the protein is doing in response to the imposed conditions, and distinguishing between amorphous and microcrystalline precipitated phases is considerably simpler...
2008: Methods in Molecular Biology
Wei Yang, Ya-Feng Zhou, He-Ping Dai, Li-Jun Bi, Zhi-Ping Zhang, Xiao-Hua Zhang, Yan Leng, Xian-En Zhang
Methyl parathion hydrolase (MPH) is an enzyme that catalyzes the degradation of methyl parathion, generating a yellow product with specific absorption at 405 nm. The application of MPH as a new labeling enzyme was illustrated in this study. The key advantages of using MPH as a labeling enzyme are as follows: (1) unlike alkaline phosphatase (AP), horseradish peroxidase (HRP), and glucose oxidase (GOD), MPH is rarely found in animal cells, and it therefore produces less background noise; (2) its active form in solution is the monomer, with a molecular weight of 37 kDa; (3) its turnover number is 114...
April 2008: Analytical and Bioanalytical Chemistry
G J Gumerman, T R Lyons
We have shown that the different spectral surveying techniques and the resultant imagery vary in their applicability to archeological prediction and exploration, but their applications are far broader than we have indicated. Their full potential, to a considerable extent, still remains unexplored. Table 1 is a chart of the more common sensor systems useful to archeological investigators. Several kinds of photography, thermal infrared imagery, and radar imagery are listed. Checks in various categories of direct and indirect utility in archeological research indicate that the different systems do provide varying degrees of input for studies in these areas...
April 9, 1971: Science
Zhengjun Li, Qingsong Lin, Jing Chen, Jin Lu Wu, Teck Kwang Lim, Siew See Loh, Xuhua Tang, Choy-Leong Hew
White spot syndrome virus (WSSV) is a major pathogen that causes severe mortality and economic losses to shrimp cultivation worldwide. The genome of WSSV contains a 305-kb double-stranded circular DNA, which encodes 181 predicted ORFs. Previous gel-based proteomics studies on WSSV have identified 38 structural proteins. In this study, we applied shotgun proteomics using off-line coupling of an LC system with MALDI-TOF/TOF MS/MS as a complementary and comprehensive approach to investigate the WSSV proteome. This approach led to the identification of 45 viral proteins; 13 of them are reported for the first time...
September 2007: Molecular & Cellular Proteomics: MCP
David P Roncone
BACKGROUND: Xerophthalmia refers to the ocular manifestations associated with vitamin A deficiency. Vitamin A deficiency can be caused by numerous disorders, including alcohol-induced malnutrition. The ocular manifestations of xerophthalmia include conjunctival and corneal xerosis (drying), keratomalacia (corneal necrosis/ulceration), nyctalopia (night blindness), and Bitot's spots (conjunctival lesions). CASE REPORT: A 47-year-old white male with complaints of dryness and difficulty seeing at night presented to our clinic for consultation from general medicine to rule out xerophthalmia...
March 2006: Optometry: Journal of the American Optometric Association
Michele A Grimbaldeston, Ching-Cheng Chen, Adrian M Piliponsky, Mindy Tsai, See-Ying Tam, Stephen J Galli
Mice carrying certain mutations in the white spotting (W) locus (ie, c-kit) exhibit reduced c-kit tyrosine kinase-dependent signaling that results in mast cell deficiency and other phenotypic abnormalities. The c-kit mutations in Kit(W/W-v) mice impair melanogenesis and result in anemia, sterility, and markedly reduced levels of tissue mast cells. In contrast, Kit(W-sh/W-sh) mice, bearing the W-sash (W(sh)) inversion mutation, have mast cell deficiency but lack anemia and sterility. We report that adult Kit(W-sh/W-sh) mice had a profound deficiency in mast cells in all tissues examined but normal levels of major classes of other differentiated hematopoietic and lymphoid cells...
September 2005: American Journal of Pathology
Thomas J T P van den Berg, Michiel P J Hagenouw, Joris E Coppens
PURPOSE: Most people see, around bright lights against dark backgrounds, a radiating pattern of numerous fine, slightly colored needles of light-the so called ciliary corona. The purpose of this study was to try to explain this phenomenon. METHODS: Recently, it has been shown that light-scattering in the eye, measured psychophysically and on human donor lenses, can be explained assuming the presence of specific distributions of small particles in the eye. Light entering the eye is diffracted by these particles...
July 2005: Investigative Ophthalmology & Visual Science
Douglas R Anderson
As distinguished from measuring the ability to see at the location where the eye's gaze is fixated, perimetry consists of determining the visual capabilities throughout the field of vision. Traditionally the ability to see a white object or a projected spot of white light is determined and quantified under standard conditions. Modern machines use automated methods to present spots of light in a programmed manner to determine the threshold of visual capability, and, after recording the data, these machines also apply statistical analyses of the results to assist the clinician in evaluation of the patient...
June 2003: Ophthalmology Clinics of North America
D C Rogers-Ramachandran, V S Ramachandran
Psychophysical evidence is given for the existence of two distinct systems in human vision: a fast, sign-invariant system concerned with extracting contours and a slower, sign-sensitive system concerned with assigning surface color. A class of stimuli we developed seems to selectively activate the fast, contour system. This stimulus is formed by adjacent fields of black and white spots, which flicker in counterphase at 15 Hz, on a uniform gray field. Although subjects can not discriminate the temporal phase relationship between the fields of spots, they can, nevertheless see a "Phantom Contour" separating the two indiscriminable fields...
January 1998: Vision Research
J Parma, L Duprez, J Van Sande, J Hermans, P Rocmans, G Van Vliet, S Costagliola, P Rodien, J E Dumont, G Vassart
A total of 33 different autonomous hot nodules from 31 patients, originating mainly from Belgium, were investigated for the presence of somatic mutations in the TSH receptor and Gs alpha genes. This constitutes an extension of our previous study, including the first 11 nodules of the series. The complete coding sequence of the TSH receptor gene and the segments of Gs alpha known to harbor mutations impairing guanosinetriphosphotase activity were studied by direct sequencing of genomic DNA extracted from the nodules...
August 1997: Journal of Clinical Endocrinology and Metabolism
M L Boisio, M Esposito, F Merlo
The present work was aimed at extracting some cardiotonic glycosides from Nerium oleander L. (N.o.L.) flowers, free from phytosterols and their esters and at resolving themselves by thick- and thin-layer chromatography. This work may contribute to the scientific recognition of N.o.L. drugs in the field of forensic medicine. MATERIALS AND METHODS. Apparatus. Kieselgel F254 thin-layer (250 mu) and Kieselgel thick-layer (2 mm) glass plates were used. MATERIALS. Chromatographic solvents were used; detectors were p-toluene sulphonic acid (PTSA) and antimony trichloride (SbCl3)...
November 1993: Minerva Medica
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