keyword
MENU ▼
Read by QxMD icon Read
search

overcoming adversity

keyword
https://www.readbyqxmd.com/read/28067173/marine-derived-anticancer-drugs-targeting-microtubule
#1
Oindrila De, Biswa Prasun Chatterji
BACKGROUND: Microtubule dynamics play a vital role in regulating crucial cellular functions and are one of the most attractive anticancer drug targets. Microtubule targeting agents (MTAs) such as the vinca alkaloids or taxanes, although are effective for cancer therapy, have adverse side effects. Another hindrance in their development is multiple drug resistance in tumor cells. These drawbacks have urged the need to develop novel MTAs from alternative sources, with better therapeutic efficacy...
January 9, 2017: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/28066958/comparison-of-patient-derived-high-and-low-phosphatidylserine-exposing-colorectal-carcinoma-cells-in-their-interaction-with-anti-cancer-peptides
#2
Dominik Wilms, Jörg Andrä
Current cancer treatment is frequently compromised by severe adverse effects on healthy cells and tissues as well as by the increasing burden of (multi-)drug resistances. Some representatives of small, amphipathic peptides known as host defense peptides possess the potential to overcome these limitations and to evolve as future anti-cancer therapeutics. Peptide NK-2, derived from porcine NK-lysin, was originally discovered due to its broad-spectrum antimicrobial activities. Today, also potent anti-cancer activity is proven and accompanied by low toxicity towards normal human cells...
January 8, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28064105/a-brief-review-on-the-application-of-nanoparticle-enclosed-herbal-medicine-for-the-treatment-of-infective-endocarditis
#3
REVIEW
Mehrdad Namdari, Ali Eatemadi, Maryam Soleimaninejad, Aiyelabegan T Hammed
Herbal medicines have been routinely employed all over the world dated back from the ancient time and have been identified by patients and physicians for their excellent therapeutic value as they have lower adverse effects when compared with the modern medicines. Phytotherapeutics requires a scientific technique to deliver the active herbal extract in a controlled manner to avoid repeated administration and increase patient compliance. This can be reached by fabricating a novel drug delivery systems (NDDS) for herbal components...
January 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28062706/combinatorial-drug-screening-identifies-ewing-sarcoma-specific-sensitivities
#4
Branka Radic-Sarikas, Kalliopi P Tsafou, Kristina B Emdal, Theodore Papamarkou, Kilian V M Huber, Cornelia Mutz, Jeffrey A Toretsky, Keiryn L Bennett, Jesper V Olsen, Søren Brunak, Heinrich Kovar, Giulio Superti-Furga
Improvements in survival for Ewing sarcoma pediatric and adolescent patients have been modest over the past 20 years. Combinations of anticancer agents endure as an option to overcome resistance to single treatments caused by compensatory pathways. Moreover, combinations are thought to lessen any associated adverse side effects through reduced dosing, which is particularly important in childhood tumors. Using a parallel phenotypic combinatorial screening approach of cells derived from three pediatric tumor types, we identified Ewing sarcoma-specific interactions of a diverse set of targeted agents including approved drugs...
January 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28058831/peptide-tethered-hydrogel-scaffold-promotes-recovery-from-spinal-cord-transection-via-synergism-with-mesenchymal-stem-cells
#5
Li-Ming Li, Min Han, Xinchi Jiang, Xianzhen Yin, Fu Chen, Tian-Yuan Zhang, Hao Ren, Jiwen Zhang, Zhong Chen, Tingjun Hou, HongWei Ouyang, Yasuhiko Tabata, Youqing Shen, Jian-Qing Gao
Spinal cord injury (SCI) is one of the most devastating injuries. Treatment strategies for SCI are required to overcome comprehensive issues. Implantation of biomaterial scaffolds and stem cells has been demonstrated to be promising strategies. However, a comprehensive recovery effect is difficult to achieve. In the comprehensive treatment process, the specific roles of the implanted scaffolds and of stem cells in combined strategy are usually neglected. In this study, a peptide-modified scaffold is developed based on hyaluronic acid and an adhesive peptide PPFLMLLKGSTR...
January 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28045616/integrating-oncology-massage-into-chemoinfusion-suites-a-program-evaluation
#6
Jun J Mao, Karen E Wagner, Christina M Seluzicki, Audra Hugo, Laura K Galindez, Heather Sheaffer, Kevin R Fox
OBJECTIVE: This article reports on the development, implementation, and evaluation of an integrative clinical oncology massage program for patients undergoing chemotherapy for breast cancer in a large academic medical center. MATERIALS AND METHODS: We describe the development and implementation of an oncology massage program embedded into chemoinfusion suites. We used deidentified program evaluation data to identify specific reasons individuals refuse massage and to evaluate the immediate impact of massage treatments on patient-reported outcomes using a modified version of the Distress Thermometer delivered via iPad...
January 3, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28042763/anatomical-suitability-of-the-zenith-off-the-shelf-p-branch-endograft-in-juxtarenal-aortic-aneurysms-previously-treated-using-the-chimney-technique
#7
Martin Schroeder, Konstantinos P Donas, Konstantinos Stavroulakis, Arne Stachmann, Giovanni Torsello, Theodosios Bisdas
PURPOSE: To examine the suitability of the Zenith off-the-shelf (p-branch) endograft in patients with juxta- or pararenal abdominal aortic aneurysms (J/PRAA) previously treated with endovascular aneurysm repair incorporating the chimney technique (chEVAR). METHODS: Between January 2012 and December 2014, high-resolution computed tomography angiograms and clinical data from 50 patients (mean age 79 years; 45 men) with J/PRAAs treated with chEVAR were retrospectively reviewed...
December 1, 2016: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/28035603/reovirus-safety-study-for-proliferation-and-differentiation-of-human-adipose-derived-mesenchymal-stem-cells
#8
Jeong-Soo Park, Manbok Kim
Naturally occurring reoviruses are live replication-proficient viruses specifically infecting human cancer cells while sparing the normal counterparts. Stem cells can be highly susceptible to viral infection due to their innate high proliferation potential and other active signaling pathways of cells that might be involved in viral tropism. In the previous study, we showed that reoviruses could adversely affect murine embryonic stem cells' integrity in vitro and in vivo. Oncolytic viruses, delivered systemically face many hurdles that also impede their localization and infection of, metastatic tumors, due to a variety of immune and physical barriers...
January 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28018902/focus-on-nivolumab-in-nsclc
#9
REVIEW
Diego L Cortinovis, Stefania Canova, Marida Abbate, Francesca Colonese, Paolo Bidoli
Immunotherapy is changing the treatment of non-small cell lung cancer (NSCLC). The PD-1 inhibitor nivolumab has demonstrated meaningful results in terms of efficacy with a good safety profile. The novel approach to treating NSCLC using immunotherapy still has unsolved questions and challenging issues. The main doubts regarding the optimal selection of the patient are the role of this drug in first line of treatment, the individualization of the correct methodology of radiologic assessment and efficacy analysis, the best management of immune-mediated adverse events, and how to overcome the immunoresistance...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/28005932/the-use-of-procalcitonin-pct-for-diagnosis-of-sepsis-in-burn-patients-a-meta-analysis
#10
Luís Cabral, Vera Afreixo, Luís Almeida, José Artur Paiva
The continuous development of resuscitation techniques and intensive care reduced the mortality rate induced by the initial shock in burn patients and, currently, infections (especially sepsis) are the main causes of mortality of these patients. The misuse of antimicrobial agents is strongly related to antimicrobial and adverse patient outcomes, development of microbial resistance and increased healthcare-related costs. To overcome these risks, antimicrobial stewardship is mandatory and biomarkers are useful to avoid unnecessary medical prescription, to monitor antimicrobial therapy and to support the decision of its stop...
2016: PloS One
https://www.readbyqxmd.com/read/28005273/nonsteroidal-anti-inflammatory-therapy-a-journey-toward-safety
#11
REVIEW
Catarina Pereira-Leite, Cláudia Nunes, Sarah K Jamal, Iolanda M Cuccovia, Salette Reis
The efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs) against inflammation, pain, and fever has been supporting their worldwide use in the treatment of painful conditions and chronic inflammatory diseases until today. However, the long-term therapy with NSAIDs was soon associated with high incidences of adverse events in the gastrointestinal tract. Therefore, the search for novel drugs with improved safety has begun with COX-2 selective inhibitors (coxibs) being straightaway developed and commercialized...
December 22, 2016: Medicinal Research Reviews
https://www.readbyqxmd.com/read/28003012/the-potential-of-nano-vehicle-mediated-therapy-in-vasculitis-and-multiple-sclerosis
#12
Ruben V Huis In T Veld, Candido G da Silva, Eric L Kaijzel, Alan B Chan, Luis J Cruz
The induction of immune tolerance towards self-antigens presents as a viable future strategy in the treatment of auto-immune diseases, including vasculitis and multiple sclerosis (MS). As specific targets are currently lacking for vasculitis due to incomplete understanding of the pathologies underlying this disease, current treatment options are based on modalities that induce general immune suppression. However, many immune suppressants used in the clinic are known to display wide biodistribution and are thus often accompanied by several adverse effects...
December 21, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28002995/the-potential-of-nano-vehicle-mediated-therapy-in-vasculitis-and-multiple-sclerosis
#13
Ruben V Huis In T Veld, Candido G da Silva, Eric L Kaijzel, Alan B Chan, Luis J Cruz
The induction of immune tolerance towards self-antigens presents as a viable future strategy in the treatment of auto-immune diseases, including vasculitis and multiple sclerosis (MS). As specific targets are currently lacking for vasculitis due to incomplete understanding of the pathologies underlying this disease, current treatment options are based on modalities that induce general immune suppression. However, many immune suppressants used in the clinic are known to display wide biodistribution and are thus often accompanied by several adverse effects...
December 21, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27989315/extended-use-of-endovascular-aneurysm-sealing-for-ruptured-abdominal-aortic-aneurysms
#14
REVIEW
Dittmar Böckler, Andrew Holden, Dainis Krievins, Jean-Paul P M de Vries, Andreas S Peters, Philipp Geisbüsch, Michel Reijnen
Endovascular repair of abdominal aortic aneurysms (EVAR) is now an established treatment modality for suitable patients presenting with aneurysm rupture. EVAR for ruptured aneurysms reduces transfusion, mechanical ventilation, intensive care. and hospital stay when compared with open surgery. In the emergency setting, however, EVAR is limited by low applicability due to adverse clinical or anatomical characteristics and increased need for reintervention. In addition, ongoing bleeding from aortic side branches post-EVAR can cause hemodynamic instability, larger hematomas, and abdominal compartment syndrome...
September 2016: Seminars in Vascular Surgery
https://www.readbyqxmd.com/read/27987248/understanding-and-overcoming-metformin-gastrointestinal-intolerance
#15
REVIEW
Fabrice Bonnet, André Scheen
Metformin is the most widely prescribed drug for patients with type 2 diabetes mellitus and the first-line pharmacologic option as supported by multiple international guidelines, yet a rather large proportion of patients cannot tolerate metformin in adequate amounts because of its associated gastrointestinal (GI) adverse events (AEs). GI AEs typically encountered with metformin therapy include diarrhoea, nausea, flatulence, indigestion, vomiting, and abdominal discomfort, with diarrhoea and nausea being the most common...
December 17, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27978790/recent-trends-in-nanotechnology-based-drugs-and-formulations-for-targeted-therapeutic-delivery
#16
Hafiz M N Iqbal, Angel Villalba, Rekha Khandia, Ashok Munjal, Kuldeep Dhama
In the recent past, a wider spectrum of nanotechnology-based drugs or drug-loaded devices/systems has been engineered and investigated though using different methodological approaches including in-vitro, in-vivo, and ex-vivo techniques. Among them, nanoparticles-based therapeutic agents have been exploited for an enhanced and efficient delivery in the current biomedical sector of the modern world. However, the development of new types of novel, efficient and highly reliable therapeutic drug delivery system (DDS) for multipurpose applications is essential and also a core demand to tackle many human health related diseases...
December 13, 2016: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/27967247/how-are-we-improving-the-delivery-to-back-of-the-eye-advances-and-challenges-of-novel-therapeutic-approaches
#17
Vibhuti Agrahari, Vivek Agrahari, Abhirup Mandal, Dhananjay Pal, Ashim K Mitra
Drug delivery to the back of the eye requires strategic approaches that guarantee the long-term therapeutic effect with patient compliance. Current treatments for posterior eye diseases suffer from significant challenges including frequent intraocular injections of anti-VEGF agents and related adverse effects in addition to the high cost of the therapy. Areas covered: Treatment challenges and promising drug delivery approaches for posterior segment eye diseases, such as age-related macular degeneration (AMD) are summarized...
December 28, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27966827/safe-and-effective-reversal-of-cancer-multidrug-resistance-using-sericin-coated-mesoporous-silica-nanoparticles-for-lysosome-targeting-delivery-in-mice
#18
Jia Liu, Qilin Li, Jinxiang Zhang, Lei Huang, Chao Qi, Luming Xu, Xingxin Liu, Guobin Wang, Lin Wang, Zheng Wang
Multidrug resistance (MDR) and adverse side effects are the major challenges facing cancer chemotherapy. Here, pH/protease dually responsive, sericin-coated mesoporous silica nanoparticles (SMSNs) for lysosomal delivery of doxorubicin (DOX) to overcome MDR and reduce systemic toxicity are reported. Sericin, a natural protein from silkworm cocoons, is coated onto MSNs as a gatekeeper via pH sensitive imine linkages. The sericin shell prevents the premature leakage of encapsulated DOX from MSNs in extracellular environment...
December 14, 2016: Small
https://www.readbyqxmd.com/read/27965496/socket-preservation-using-enzyme-treated-equine-bone-granules-and-an-equine-collagen-matrix-a-case-report-with-histological-and-histomorphometrical-assessment
#19
Alessandro Leonida, Giovanni Todeschini, Giovanni Lomartire, Lorenzo Cinci, Laura Pieri
AIM: To histologically assess the effectiveness of a socket-preservation technique using enzyme-treated equine bone granules as a bone-graft material in combination with an equine collagen matrix as a scaffold for soft-tissue regeneration. BACKGROUND: Enzyme-treated equine bone granules and equine collagen matrix recently have been developed to help overcome alveolar bone deficiencies that develop in the wake of edentulism. CASE REPORT: The patient had one mandibular molar extracted and the socket grafted with equine bone granules...
November 1, 2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27964771/exploring-how-lay-rescuers-overcome-barriers-to-provide-cardiopulmonary-resuscitation-a-qualitative-study
#20
Wenche Torunn Mathiesen, Conrad Arnfinn Bjørshol, Sindre Høyland, Geir Sverre Braut, Eldar Søreide
BACKGROUND: Survival rates after out-of-hospital cardiac arrest (OHCA) vary considerably among regions. The chance of survival is increased significantly by lay rescuer cardiopulmonary resuscitation (CPR) before Emergency Medical Services (EMS) arrival. It is well known that for bystanders, reasons for not providing CPR when witnessing an OHCA incident may be fear and the feeling of being exposed to risk. The aim of this study was to gain a better understanding of why barriers to providing CPR are overcome...
December 14, 2016: Prehospital and Disaster Medicine
keyword
keyword
53318
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"