keyword
MENU ▼
Read by QxMD icon Read
search

overcoming adversity

keyword
https://www.readbyqxmd.com/read/28547932/from-intraperitoneal-onlay-mesh-repair-to-preperitoneal-onlay-mesh-repair
#1
REVIEW
George Pei Cheung Yang
Laparoscopic repair for ventral and incisional hernias was first reported in the early 1990s. It uses intraperitoneal only mesh placement to achieve a tension-free repair of the hernia. However, in recent years, there has been greater concern about long-term complication involving intraperitoneal mesh placement. Many case reports and case series have found evidence of mesh adhesion, mesh fistulation, and mesh migration into hollow organs including the esophagus, small bowel, and large bowel, resulting in various major acute abdominal events...
May 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/28546525/pazopanib-for-the-treatment-of-non-clear-cell-renal-cell-carcinoma-a-single-arm-open-label-multicenter-phase-ii-study
#2
Ki Sun Jung, Su Jin Lee, Se Hoon Park, Jae-Lyun Lee, Se-Hoon Lee, Jae Yun Lim, Jung Hun Kang, Suee Lee, Sun Young Rha, Kyung Hee Lee, Ho Young Kim, Ho Yeong Lim
Purpose: The optimal treatment strategy for patients with metastatic non-clear cell type renal cell carcinoma (nccRCC) remains unclear. Although several inhibitors of vascular endothelial growth factor have recently shown efficacy against nccRCC, the clinical benefit of pazopanib in nccRCC has not been analyzed. We therefore designed a single-arm, open-label, phase II study to determine the efficacy and safety of pazopanib in patients with nccRCC. Materials and Methods: Patients with locally advanced or metastatic nccRCC, except for collecting duct or sarcomatoid type, received 800mg/day of pazopanib daily until progression of disease or intolerable toxicity...
May 22, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28540831/ninety-percent-of-the-adverse-outcomes-occur-in-ten-percent-of-patients-can-we-identify-the-populations-at-high-risk-of-developing-peritoneal-metastases-after-curative-surgery-for-colorectal-cancer
#3
Charles Honoré, Maximiliano Gelli, Julie Francoual, Léonor Benhaim, Dominique Elias, Diane Goéré
BACKGROUND: Peritoneal metastases (PM) occur in 3.4% to 6.3% after curative surgery for non-metastatic colorectal cancer. Systematic "2(nd) look" surgery help overcoming the diagnostic problem but can be only proposed to selected patients. The aim of this study was to update the knowledge on risk factors of developing PM after curative surgery for colorectal cancer. METHODS: A systematic review of the literature published between 2011 and 2016 was made, searching for all clinical studies reporting the incidence of recurrent PM after curative surgery for colorectal cancer and factors associated with the primary tumor that were likely to influence this recurrence rate...
March 29, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28540641/evaluation-of-penicillin-allergy-in-the-hospitalized-patient-opportunities-for-antimicrobial-stewardship
#4
REVIEW
Justin R Chen, David A Khan
PURPOSE OF REVIEW: Penicillin allergy is often misdiagnosed and is associated with adverse consequences, but testing is infrequently done in the hospital setting. This article reviews historical and contemporary innovations in inpatient penicillin allergy testing and its impact on antimicrobial stewardship. RECENT FINDINGS: Adoption of the electronic medical record allows rapid identification of admitted patients carrying a penicillin allergy diagnosis. Collaboration with clinical pharmacists and the development of computerized clinical guidelines facilitates increased testing and appropriate use of penicillin and related β-lactams...
June 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28540165/nanotechnology-based-strategies-for-treatment-of-ocular-disease
#5
REVIEW
Yuhua Weng, Juan Liu, Shubin Jin, Weisheng Guo, Xingjie Liang, Zhongbo Hu
Ocular diseases include various anterior and posterior segment diseases. Due to the unique anatomy and physiology of the eye, efficient ocular drug delivery is a great challenge to researchers and pharmacologists. Although there are conventional noninvasive and invasive treatments, such as eye drops, injections and implants, the current treatments either suffer from low bioavailability or severe adverse ocular effects. Alternatively, the emerging nanoscience and nanotechnology are playing an important role in the development of novel strategies for ocular disease therapy...
May 2017: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/28537800/advanced-mri-techniques-for-the-hip-joint-focus-on-the-postoperative-hip
#6
Jennifer L Berkowitz, Hollis G Potter
OBJECTIVE: Imaging the hip joint with optimized MRI protocol parameters provides the radiologist with the ability to reliably diagnose complex hip abnormalities. The institution of appropriate metal artifact reduction techniques and dedicated sequences can enhance visualization of the periprosthetic bone and soft tissues and allow improved detection of the more frequently encountered total hip arthroplasty-related conditions, such as mechanical loosening, polyethylene wear, and adverse local tissue reactions...
May 24, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28536872/cytoprotective-propensity-of-green-tea-polyphenols-against-citrinin-induced-skeletal-myotube-damage-in-c2c12-cells
#7
G R Sharath Babu, N Ilaiyaraja, Farhath Khanum, T Anand
The mycotoxin citrinin, is produced by several species of Penicillium, Aspergillus and Monascus, and is capable of inducing cytotoxicity, oxidative stress and apoptosis. The aim of the present study was to investigate the effect of citrinin in mouse skeletal muscle cells (C2C12) and to overcome the cellular adverse effects by supplementing green tea extract (GTE) rich in polyphenols. C2C12 myoblasts were differentiated to myotubes and were exposed to citrinin in a dose dependent manner (0-100 µM) for 24 h and IC50 value was found to be 100 µM that resulted in decreased cell viability, increased LDH leakage and compromised membrane integrity...
May 23, 2017: Cytotechnology
https://www.readbyqxmd.com/read/28536307/gene-expression-profiling-in-braf-mutated-melanoma-reveals-patient-subgroups-with-poor-outcomes-to-vemurafenib-that-may-be-overcome-by-cobimetinib-plus-vemurafenib
#8
Matthew J Wongchenko, Grant A McArthur, Brigitte Dréno, James Larkin, Paolo A Ascierto, Jeffrey Sosman, Luc Andries, Mark Kockx, Stephen D Hurst, Ivor Caro, Isabelle Rooney, Priti S Hegde, Luciana Molinero, Huibin Yue, Ilsung Chang, Lukas C Amler, Yibing Yan, Antoni Ribas
The association of tumor gene expression profiles with progression-free survival (PFS) outcomes in patients with BRAF(V600)-mutated melanoma treated with vemurafenib or cobimetinib combined with vemurafenib was evaluated. <br /><br />Experimental Design: Gene expression of archival tumor samples from patients in four trials (BRIM-2, BRIM-3, BRIM-7, and coBRIM) was evaluated. Genes significantly associated with PFS (P<0 .05) were identified by univariate Cox proportional hazards modeling, then subjected to unsupervised hierarchical clustering, principal component analysis, and recursive partitioning to develop optimized gene signatures...
May 23, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28534597/metabolomics-for-improving-pregnancy-outcomes-in-women-undergoing-assisted-reproductive-technologies
#9
REVIEW
Charalampos S Siristatidis, Eleni Sertedaki, Dennis Vaidakis
BACKGROUND: In order to overcome the low effectiveness of assisted reproductive technologies (ART) and the high incidence of multiple births, metabolomics is proposed as a non-invasive method to assess oocyte quality, embryo viability, and endometrial receptivity, and facilitate a targeted subfertility treatment. OBJECTIVES: To evaluate the effectiveness and safety of metabolomic assessment of oocyte quality, embryo viability, and endometrial receptivity for improving live birth or ongoing pregnancy rates in women undergoing ART, compared to conventional methods of assessment...
May 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28532268/allergen-immunotherapy-in-allergic-rhinitis-current-use-and-future-trends
#10
Ludger Klimek, Oliver Pfaar, Jean Bousquet, Gabriela Senti, Thomas Kündig
Type-1 allergies are among the most chronic common diseases of humans. Allergen immunotherapy (AIT) is the only causative and disease-modifying treatment option besides allergen avoidance. Severe systemic adverse allergic reactions may be induced by every AIT treatment. Different approaches have been used to provide safer AIT preparations to lower or even totally overcome this risk. Areas covered: A structured literature recherche in Medline and Pubmed under inclusion of national and international guidelines and Cochrane meta-analyses has been performed aiming at reviewing clinical use of such approaches in AIT...
May 23, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28531761/3%C3%AE-hydroxy-urs-12-en-28-oic-acid-confers-protection-against-znonps-induced-adversity-in-caenorhabditis-elegans
#11
Hema Negi, Shilpi Khare Saikia, Ranjana Kanaujia, Satish Jaiswal, Rakesh Pandey
Despite their well reported potent risk towards human health and environment Zinc oxide nanoparticles (ZnONPs) find an extensive commercial usage due to their antimicrobial properties. Here, we evaluated the efficacy of a natural triterpene ursolic acid (3β-hydroxy-urs-12-en-28-oic acid; UA) for overcoming the cytotoxic challenges of ZnONPs employing Ceanorhabditis elegans. The 24h LC50 of Zn-ONPs (<50nm TEM) was deduced as 4.75mgL(-1). UA (25μM) was observed to defend against this toxicity by attenuating Reactive Oxygen Species (ROS) resulting into better survival at 2mgL(-1) in a time dependent behavior...
May 8, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28523359/arginine-cga-codons-as-a-source-of-nonsense-mutations-a-possible-role-in-multivariant-gene-expression-control-of-mrna-quality-and-aging
#12
Georgy A Romanov, Victor S Sukhoverov
Methylation of cytosine residues in DNA of higher eukaryotes, including humans, creates "hot spots" of C→T transitions in the genome. The predominantly methylated sequence in mammalian DNAs is CG (CpG). Among CG-containing codons, CGA codons for arginine are unique due to their ability to create stop codons TGA (UGA in mRNA) upon epigenetic-mediated mutation. As such nonsense mutations can have a strong adverse effect on the cell and organism, we have performed a study, on the example of human genes, aimed to characterise the anticipated effects of epigenetic-mediated nonsense mutations CGA→TGA in somatic cells...
May 18, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28522956/fecal-microbiota-transplantation-for-refractory-crohn-s-disease
#13
Seon Ho Bak, Hyun Ho Choi, Jinhee Lee, Mi Hee Kim, Youn Hee Lee, Jin Su Kim, Young-Seok Cho
Approximately one-third of patients with Crohn's disease do not respond to conventional treatments, and some experience significant adverse effects, such as serious infections and lymphoma, and many patients require surgery due to complications. Increasing evidence suggests that specific changes in the composition of gut microbiota, termed as dysbiosis, are a common feature in patients with inflammatory bowel disease (IBD). Dysbiosis can lead to activation of the mucosal immune system, resulting in chronic inflammation and the development of mucosal lesions...
April 2017: Intestinal Research
https://www.readbyqxmd.com/read/28520548/intracoronary-hypothermia-before-reperfusion-to-reduce-reperfusion-injury-in-acute-myocardial-infarction-a-novel-hypothesis-and-technique
#14
Luuk C Otterspoor, Lokien X van Nunen, Marcel van 't Veer, Nils P Johnson, Nico H J Pijls
Because current reperfusion strategies in acute myocardial infarction (AMI) seem to be exhausted in terms of additional mortality benefit, there remains a need for new methods to attenuate reperfusion injury and, thereby, further reduce myocardial infarct size and improve long-term survival. Therapeutic hypothermia (32-35°C) diminishes reperfusion injury and reduces infarct size in a variety of animal models of AMI if provided before reperfusion. In human studies this reduction has not been confirmed so far, most likely because systemic cooling acts slowly, and therefore, the target temperature is not reached in time or at all in a substantial number of patients...
May 18, 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28507794/a-novel-nanobody-based-target-module-for-retargeting-of-t-lymphocytes-to-egfr-expressing-cancer-cells-via-the-modular-unicar-platform
#15
Susann Albert, Claudia Arndt, Anja Feldmann, Ralf Bergmann, Dominik Bachmann, Stefanie Koristka, Florian Ludwig, Pauline Ziller-Walter, Alexandra Kegler, Sebastian Gärtner, Marc Schmitz, Armin Ehninger, Marc Cartellieri, Gerhard Ehninger, Hans-Jürgen Pietzsch, Jens Pietzsch, Jörg Steinbach, Michael Bachmann
Recent treatments of leukemias with chimeric antigen receptor (CAR) expressing T cells underline their impressive therapeutic potential. However, once adoptively transferred into patients, there is little scope left to shut them down after elimination of tumor cells or in case adverse side effects occur. This becomes of special relevance if they are directed against commonly expressed tumor associated antigens (TAAs) such as receptors of the ErbB family. To overcome this limitation, we recently established a modular CAR platform technology termed UniCAR...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28506217/association-between-maternal-social-deprivation-and-prenatal-care-utilization-the-precare-cohort-study
#16
Clémentine Gonthier, Candice Estellat, Catherine Deneux-Tharaux, Béatrice Blondel, Toni Alfaiate, Thomas Schmitz, Jean-François Oury, Laurent Mandelbrot, Dominique Luton, Philippe Ravaud, Elie Azria
BACKGROUND: Maternal social deprivation is associated with an increased risk of adverse maternal and perinatal outcomes. Inadequate prenatal care utilization (PCU) is likely to be an important intermediate factor. The health care system in France provides essential health services to all pregnant women irrespective of their socioeconomic status. Our aim was to assess the association between maternal social deprivation and PCU. METHODS: The analysis was performed in the database of the multicenter prospective PreCARE cohort study...
May 16, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28505300/impact-of-glutathione-metabolism-on-zinc-homeostasis-in-saccharomyces-cerevisiae
#17
Matthias G Steiger, Anett Patzschke, Caterina Holz, Christine Lang, Tim Causon, Stephan Hann, Diethard Mattanovich, Michael Sauer
Zinc is a crucial mineral for all organisms as it is an essential cofactor for the proper function of a plethora of proteins and depletion of zinc causes oxidative stress. Glutathione is the major redox buffering agent in the cell and therefore important for mitigation of the adverse effects of oxidative stress. In mammalian cells, zinc deficiency is accompanied by a glutathione depletion. In the yeast Saccharomyces cerevisiae, the opposite effect is observed: under low zinc conditions an elevated glutathione concentration is found...
May 12, 2017: FEMS Yeast Research
https://www.readbyqxmd.com/read/28504001/n-acetylcysteine-potentiates-diclofenac-toxicity-in-saccharomyces-cerevisiae-stronger-potentiation-in-abc-transporter-mutant-strains
#18
Houssein Al-Attrache, Hala Chamieh, Monzer Hamzé, Isabelle Morel, Samir Taha, Ziad Abdel-Razzak
Diclofenac (DCF) adverse reactions involve diverse mechanisms in different models. We recently demonstrated that DCF-induced toxicity in HepaRG decreases as they express DCF-metabolizing enzymes. DCF metabolism promotes toxicity in Saccharomyces cerevisiae expressing heterologous cytochromes-P450. N-Acetylcysteine (NAC) is used to treat diverse medical conditions due to its multiple properties (antioxidant, metal chelator, thiol-disulfide disruption). The latter property accounts for its mucolytic effects and broadens its potential molecular targets to signal transduction proteins, ABC transporters and others...
May 15, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/28499265/nanoagroparticles-emerging-trends-and-future-prospect-in-modern-agriculture-system
#19
REVIEW
Syed Baker, Tatiana Volova, Svetlana V Prudnikova, S Satish, Nagendra Prasad M N
Increment of technical knowledge has remarkably uplifted logical thinking among scientific communities to shape the theoretical concepts into near product-oriented research. The concept of nanotechnology has overwhelmed almost all forms of lives and has traded its applications in myriad fields. Despite rapid expansion of nanotechnology, sustainable competitions still do exist in the field of agriculture. In current scenario, agriculture is a manifestation demand to provide adequate nutrition for relentless growing global population...
April 23, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28494828/treatment-of-persistent-pulmonary-hypertension-of-the-newborn-use-of-pulmonary-vasodilators-in-term-neonates
#20
Caitlyn Luecke, Christopher McPherson
Persistent pulmonary hypertension of the newborn (PPHN) represents a challenging condition associated with significant morbidity. A successful transition from intrauterine to extrauterine life is contingent on adequate pulmonary vasodilation. Several pathophysiologies contribute to the failure of this cascade and may result in life-threatening hypoxia and acidosis in the newborn. Management includes optimal respiratory support, adequate sedation and analgesia, and support of vascular tone and cardiac function...
May 1, 2017: Neonatal Network: NN
keyword
keyword
53318
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"