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overcoming adversity

Vaibhav Pandey, Poonam Saini
MapReduce (MR) computing paradigm and its open source implementation Hadoop have become a de facto standard to process big data in a distributed environment. Initially, the Hadoop system was homogeneous in three significant aspects, namely, user, workload, and cluster (hardware). However, with growing variety of MR jobs and inclusion of different configurations of nodes in the existing cluster, heterogeneity has become an essential part of Hadoop systems. The heterogeneity factors adversely affect the performance of a Hadoop scheduler and limit the overall throughput of the system...
June 2018: Big Data
Shaik Mohamed Shamsudeen, R Shanmuga Priya, Govindarajan Sujatha, J Muruganandhan, K Manikandan
INTRODUCTION: Antibiotics are considered the most commonly sold drugs in developing countries. In India, these drugs are very much accessible without a prescription. This irrational and misuse of antibiotics results not only in the emergence of resistance of bacterial strains but also leads to adverse reactions. AIM: The aim of this study was to investigate the level of knowledge, attitude, and practice of antibiotics usage among dental patients. MATERIALS AND METHODS: Study design: This study was a cross-sectional design; a prevalidated structured questionnaire comprising 24 questions was used...
2018: Journal of Education and Health Promotion
Kim Foster, Celeste Cuzzillo, Trentham Furness
WHAT IS KNOWN ON THE SUBJECT?: Mental health nurses are affected by interpersonal, practice-related and organizational factors that can increase workplace stress and reduce their physical and mental health and well-being. Resilience programmes are a strength-based preventative approach to supporting individuals to overcome workplace adversities. WHAT THE PAPER ADDS TO EXISTING KNOWLEDGE?: This qualitative inquiry is the first study to report mental health nurses' perspectives and experiences on a workplace resilience programme...
June 19, 2018: Journal of Psychiatric and Mental Health Nursing
Woohyun Kim, Sijung Yoo, Chanyoung Yoo, Eui-Sang Park, Jeongwoo Jeon, Young Jae Kwon, Kyung Seok Woo, Han Joon Kim, Yoon Kyeung Lee, Cheol Seong Hwang
The ovonic threshold switch (OTS) based on the voltage snapback of amorphous chalcogenides possesses several desirable characteristics for passive memory array. Among the materials that can be used as OTS, GeSe has a strong glass-forming ability (~350°C crystallization temperature), with a simple binary composition. Described herein is a new method of depositing GeSe films through atomic layer deposition (ALD), in which HGeCl3 and [(CH3)3Si]2Se are used as Ge and Se precursors, respectively. The stoichiometric GeSe thin films were formed through a ligand exchange reaction between the two precursor molecules, without the adoption of an additional reaction gas, at low substrate temperatures ranging from 70 to 150°C...
June 19, 2018: Nanotechnology
Shinsuke Otagiri, Shunsuke Ohnishi, Arisa Miura, Hiroshi Hayashi, Izumi Kumagai, Yoichi M Ito, Takehiko Katsurada, Shiro Nakamura, Rika Okamoto, Kenichi Yamahara, Kyu Yong Cho, Toshiyuki Isoe, Norihiro Sato, Naoya Sakamoto
Introduction: The medical treatment options for patients with Crohn's disease (CD) are limited and patients resistant to those therapies are left requiring surgical operations that usually only achieve some symptomatic relief. Mesenchymal stem cells (MSC) have been shown to be effective for the treatment of CD, and we have demonstrated in animal experiments that human amnion-derived MSCs (AMSC) are a potential new therapeutic strategy. Therefore, we designed this study to investigate the safety and efficacy of AMSCs in patients with treatment-resistant CD...
2018: BMJ Open Gastroenterology
Jung Min Bae, Ji Hae Lee, Hyuck Sun Kwon, Jiehoon Kim, Dong Seok Kim
BACKGROUND: Punch grafting for vitiligo has been time-consuming and may result in cobblestone-like appearances. We devised a motorized 0.8 mm micro-punch grafting procedure to overcome these limitations. OBJECTIVE: To assess the therapeutic effectiveness and adverse events associated with micro-punch grafting in refractory vitiligo. METHODS: We retrospectively reviewed 230 lesions in 208 patients with stable vitiligo who underwent motorized 0...
June 15, 2018: Journal of the American Academy of Dermatology
Neelam Dogra, Rajat Dadheech, Mahipal Dhaka, Anupama Gupta
Background and Aims: Caudal block is a safe and simple method of pain relief in young children with the drawback of a short duration of analgesia which can be overcome by adding various adjuvants to the injected local anaesthetic. We compared the effects of caudal levobupivacaine, tramadol and a combination of both in paediatric patients undergoing inguinal herniotomy. Methods: A total of 78 children aged 1-7 years, planned for inguinal herniotomy were randomly allocated into three groups...
May 2018: Indian Journal of Anaesthesia
Ramona Danielson, Gregory F Sanders
Childhood adversity (CA) has life-long effects that we are just beginning to understand. The Midlife in the United States (MIDUS) data is a rich resource that could contribute to the knowledge of the impact of CA in the later years but, while a number of CA items are included in MIDUS, a cumulative CA scale based on those items has not been created. Development of a CA scale would create numerous research opportunities within MIDUS and overcome some of the challenges of using a secondary dataset. The present study aimed to demonstrate that a cumulative measure of CA that is valid with older adults could be created using retrospective MIDUS Refresher study data (Ryff et al...
June 12, 2018: Child Abuse & Neglect
Barry Danby Michael
This Commentary focuses on the landmark paper about hypoxia in radiotherapy by Gray, Scott et al published in 1953. By then, it was known that hypoxic regions in tumours could make them resistant to radiation treatment and that this was a possible cause of failure. The paper proposed that oxygen breathing could substantially decrease this resistance without incurring significant additional damage to normal tissues, thus reducing the likelihood of recurrence. Although the paper's supporting data were in some respects incomplete, the case it made was convincing and it prompted pilot clinical trials that combined radiotherapy with oxygen breathing, including under elevated pressure...
June 15, 2018: British Journal of Radiology
Nicola Heslehurst, Heather Brown, Augustina Pemu, Hayley Coleman, Judith Rankin
BACKGROUND: Global migration is at an all-time high with implications for perinatal health. Migrant women, especially asylum seekers and refugees, represent a particularly vulnerable group. Understanding the impact on the perinatal health of women and offspring is an important prerequisite to improving care and outcomes. The aim of this systematic review was to summarise the current evidence base on perinatal health outcomes and care among women with asylum seeker or refugee status. METHODS: Twelve electronic database, reference list and citation searches (1 January 2007-July 2017) were carried out between June and July 2017...
June 12, 2018: BMC Medicine
Esther Kalule Nanfuka, David Kyaddondo, Sarah N Ssali, Narathius Asingwire
BACKGROUND: Despite the national roll-out of free HIV medicines in Uganda and other sub-Saharan African countries, many HIV positive patients on antiretroviral therapy (ART) are at risk of non-adherence due to poverty and other structural and health system related constraints. However, several patients exhibit resilience by attaining and sustaining high levels of adherence amid adversity. Social capital, defined as resources embedded within social networks, is key in facilitating resilience but the mechanism through which it operates remains understudied...
2018: PloS One
Hassan Salmanroghani, Massoud Mirvakili, Mahmud Baghbanian, Roham Salmanroghani, Golshid Sanati, Pouria Yazdian
AIM: To evaluate the efficacy and tolerability of tetracycline vs. high-dose amoxicillin in bismuth-based quadruple therapy for Helicobacter pylori(H. pylori) eradication. METHODS: This randomized, open-label clinical trial included 228 patients with H.pylori infection and duodenal ulcer without a history of H.pylori treatment. Patients were randomly divided into two groups. The amoxicillin group received metronidazole 500mg, bismuth subcitrate 240mg, and amoxicillin 1000mg, all three times a day, plus omeprazole 20 mg twice a day, for 14 days...
2018: PloS One
Andreas Møllerløkken
Norway has a long tradition of quality research within the field of baromedicine. With the discovery of oil in the North Sea, it became important to establish scientific research facilities to overcome immediate challenges, but also to work towards long-term goals. For the diving community, an understanding of the pathophysiology of decompression sickness (DCS) has been one of the major forces to maintain focus on the importance of scientific research in this field. In addition to oil, the aquaculture and fish farming industries are increasing in size and are Norway's second biggest export industry today...
June 30, 2018: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
Julian Hlouschek, Christine Hansel, Verena Jendrossek, Johann Matschke
Pronounced resistance of lung cancer cells to radiotherapy and chemotherapy is a major barrier to successful treatment. Herein, both tumor hypoxia and the upregulation of the cellular antioxidant defense systems observed during malignant progression can contribute to radioresistance. We recently found that exposure to chronic cycling severe hypoxia/reoxygenation stress results in glutamine-dependent upregulation of cellular glutathione (GSH) levels and associated radiation resistance opening novel routes for tumor cell-specific radiosensitization...
2018: Frontiers in Oncology
Md Sahab Uddin, Abdullah Al Mamun, Md Asaduzzaman, Fakhrul Hosn, Mohammad Abu Sufian, Shinya Takeda, Oscar Herrera-Calderon, Mohamed M Abdel-Daim, G M Sala Uddin, Md Ali Asif Noor, Mst Marium Begum, Md Tanvir Kabir, Sonia Zaman, Md Shahid Sarwar, Md Mosiqur Rahman, Md Rajdoula Rafe, Md Farhad Hossain, Md Sarwar Hossain, Mohammed Ashraful Iqbal, Md Ataur Rahman Sujan
Background: Neurological disorders represent one of the most prominent causes of morbidity and mortality that adversely affect the lifestyle of patients and a major percentage of these diseases exists in developing countries. Purpose: The objective of this study was to examine the prevalence and prescription pattern for outpatients with neurological disorders in Bangladesh. Methods: The study was conducted on 1,684 patients in 6 hospitals (National Institute of Neurosciences and Hospital, Dhaka Medical College and Hospital, Bangabandhu Sheikh Mujib Medical University, Shaheed Suhrawardy Medical College, Sir Salimullah Medical College, and Apollo Hospitals Dhaka) of the Dhaka City from March 2014 to June 2015...
April 2018: Annals of Neurosciences
Marc Baay, Kaatje Bollaerts, Thomas Verstraeten
INTRODUCTION: New adjuvants have been developed to improve the efficacy of vaccines and for dose-sparing capacity and may overcome immuno senescence in the elderly. We reviewed the safety of newly-adjuvanted vaccines in older adults. METHODS: We searched Medline for clinical trials (CTs) including new adjuvant systems (AS01, AS02, AS03, or MF59), used in older adults, published between 01/1995 and 09/2017. Safety outcomes were: serious adverse events (SAEs); solicited local and general AEs (reactogenicity); unsolicited AEs; and potentially immune-mediated diseases (pIMDs)...
June 6, 2018: Vaccine
Seo-Joon Lee, Gyoun-Yon Cho, Tae-Ro Lee
BACKGROUND: Sleep disorders lead to many adverse complications and chronic diseases. Sleep disorder-related healthcare costs are tens of billions of dollars worldwide. Sleep monitoring solutions have thus been the focus of research and industrial interest. However, the problem of limited bandwidth and battery consumption hinders the accuracy and practical use of sleep monitoring aids. INTRODUCTION: The aim of this study is to propose Near-Lossless Wireless Real-time Efficient electroencephalogram Transmission Solution (N-WRETS) solution that solves the issue of limited bandwidth and battery consumption, thereby supporting platforms dedicated to sleep disorder monitoring...
June 7, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
Bharathi Upadhya, Mark J Haykowsky, Dalane W Kitzman
Heart failure (HF) with preserved ejection fraction (HFpEF) is the most common form of HF. Among elderly women, HFpEF comprises more than 80% of incident HF cases. Adverse outcomes-exercise intolerance, poor quality of life, frequent hospitalizations, and reduced survival-approach those of classic HF with reduced EF (HFrEF). However, despite its importance, our understanding of the pathophysiology of HFpEF is incomplete, and despite intensive efforts, optimal therapy remains uncertain, as most trials to date have been negative...
June 7, 2018: Heart Failure Reviews
Zahid Hussain, Mahwish Arooj, Arif Malik, Fahad Hussain, Hassan Safdar, Shahzeb Khan, Muhammad Sohail, Manisha Pandey, Hira Choudhury, Hnin Ei Thu
Development and formulation of an efficient and safe therapeutic regimen for cancer theranostics are dynamically challenging. The use of mono-therapeutic cancer regimen is generally restricted to optimal clinical applications, on account of drug resistance and cancer heterogeneity. Combinatorial treatments can employ multi-therapeutics for synergistic anticancer efficacy whilst reducing the potency of individual moieties and diminishing the incidence of associated adverse effects. The combo-delivery of nanotherapeutics can optimize anti-tumor efficacy while reversing the incidence of drug resistance, aiming to homogenize pharmacological profile of drugs, enhance circulatory time, permit targeted drug accumulation, achieve multi-target dynamic approach, optimize target-specific drug binding and ensure sustained drug release at the target site...
June 6, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Yuexiang Liang, Donglei He, Liangliang Wu, Xuewei Ding, Xiaona Wang, Baogui Wang, Rupeng Zhang, Han Liang
Objective: Elevated plasma D-dimer has been reported to be associated with advanced tumor stage and poor survival in several types of malignancies. The purpose of this study was to assess the potential impact of preoperative plasma D-dimer level (PDL) on overall survival (OS) of gastric cancer (GC) patients undergoing curative surgery by applying propensity score analysis. Methods: A total of 1,025 curatively resected GC patients in Tianjin Medical University Cancer Institute & Hospital were enrolled...
April 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
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