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Giuseppe Pasqualetti, Marta Seghieri, Eleonora Santini, Chiara Rossi, Edoardo Vitolo, Livia Giannini, Maria Giovanna Malatesta, Valeria Calsolaro, Fabio Monzani, Anna Solini
Heart failure (HF) is one of the most frequent cause of hospitalization in elderly and often coexists with concurrent geriatric syndromes, like cognitive disturbances; various pathophysiological mechanisms are shared by HF and cognitive decline, notably a substrate of low-grade inflammation. We investigated whether SNPs in the purinergic receptor (P2X7R) and apolipoprotein (APO) E genes, both involved in a series of inflammatory responses, are associated to HF or cognitive impairment and are able to predict post-discharge mortality in the elderly...
July 2017: Aging and Disease
Shanshan Luo, Tran Ba Hieu, Fenfen Ma, Ying Yu, Zhonglian Cao, Minjun Wang, Weijun Wu, Yicheng Mao, Peter Rose, Betty Yuen-Kwan Law, Yi Zhun Zhu
Selective treatments for myocardial infarction (MI) induced cardiac fibrosis are lacking. In this study, we focus on the therapeutic potential of a synthetic cardio-protective agent named ZYZ-168 towards MI-induced cardiac fibrosis and try to reveal the underlying mechanism. ZYZ-168 was administered to rats with coronary artery ligation over a period of six weeks. Ecocardiography and Masson staining showed that ZYZ-168 substantially improved cardiac function and reduced interstitial fibrosis. The expression of α-smooth muscle actin (α-SMA) and Collagen I were reduced as was the activity of matrix metalloproteinase 9 (MMP-9)...
March 7, 2017: Scientific Reports
Lara García-Álvarez, María Mercedes Sanz, Mercedes Marín, MCarmen Fariñas, Miguel Montejo, Josune Goikoetxea, Raquel Rodríguez García, Arístides de Alarcón, Manuel Almela, Núria Fernández-Hidalgo, María Del Mar Alonso Socas, Miguel Ángel Goenaga, Enrique Navas, Luis Vicioso, José Antonio Oteo
Tropheryma whipplei endocarditis is an uncommon condition with very few series and <90 cases reported in the literature. The aim of the study was to analyze the epidemiological, clinical, and outcome characteristics of 17 cases of T. whipplei endocarditis recruited in our country from a multicentric cohort from 25 Spanish hospitals from the Spanish Collaboration on Endocarditis-Grupo de Apoyo al Manejo de la Endocarditis infecciosa en España.From a total of 3165 cases included in the cohort, 14.2% were diagnosed of blood culture negative endocarditis (BCNE) and 3...
June 2016: Medicine (Baltimore)
Eva Pilar Álvarez, Francis Rey, Sara Carolina Peña, Aranzazu Rubio, Cristina Calvo, Paz Collado
OBJECTIVE: Kawasaki disease (KD) is an acute systemic vasculitis affecting medium-sized arteries, particularly the coronary arteries. Classic diagnosis is based in prolonged fever and different clinical features, including acute arthritis. Our objective is to determine the prevalence of arthritis at the moment of the diagnosis, the response to intravenous immunoglobulin infusion and the relation with cardiac findings. MATERIAL AND METHODS: Retrospective study through review of medical records of 42 patients with KD from 1988 to 2013...
May 2017: Reumatología Clinica
Daniel Palanca Arias, Marta López Ramón, Lorenzo Jiménez Montañés
Although extrarenal manifestations of haemolytic-uraemic syndrome are not frequent, myocardial dysfunction should be given special consideration because of the importance of proper early haemodynamic management and potential complications. We report the case of a 21-month-old child with haemolytic-uraemic syndrome who developed clinical signs of poor myocardial function with depressed myocardial function noted by bedside echocardiography and significant elevation of biomarkers. Early intervention and supportive treatment for the patient were crucial during the acute phase of cardiac failure, and repeated monitoring of biomarkers and ecocardiography were useful diagnostic tools that provided relevant information throughout the patient's evolution...
June 2016: Cardiology in the Young
Irem Kirac Utku, Yildiz Okuturlar, Esra Demir, Ozlem Harmankaya, Gonul Aciksari, Turgut Uygun, Alev Kural, Hanise Ozkan, Meral Mert, Abdulbaki Kumbasar
INTRODUCTION: Metabolic syndrome is a systemic disorder and manifests as a group of conditions including abdominal obesity, dyslipidemia, hypertension and coronary artery disease. The importance of epicardial adipose tissue has been proven through recognition of its contribution to inflammation by pro-inflammatory cytokine discharge. Several investigations have been performed on vitamin D receptors in different tissues. In this study, epicardial adipose tissue thickness (EATT) and the levels of vitamin D were measured and compared with a healthy control group...
2015: International Journal of Clinical and Experimental Medicine
Pedro Gonçalo Ferreira, Susana Costa, Nuno Dias, António Jorge Ferreira, Fátima Franco
Venlafaxine is a serotonin-norepinephrine reuptake inhibitor used as an antidepressant. Interindividual variability and herb-drug interactions can lead to drug-induced toxicity. We report the case of a 35-year-old female patient diagnosed with synchronous pneumonitis and acute cardiomyopathy attributed to venlafaxine. The patient sought medical attention due to dyspnea and dry cough that started three months after initiating treatment with venlafaxine for depression. The patient was concomitantly taking Centella asiatica and Fucus vesiculosus as phytotherapeutic agents...
May 2014: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Cristina Ferreira Rabelo, Fabio Batistella, Ronaldo Nunes Godinho, Tiago Santini Machado, Flavio José Petersen Velho, Henrique Luiz Staub
OBJECTIVES: Myocarditis is a rare but serious manifestation of patients with systemic lupus erythematosus (SLE). Left ventricular noncompaction (LVNC) is a disorder of myocardial morphogenesis frequently associated to neuromuscular diseases. Hypertrabeculation, a cardinal echocardiographic feature of LVNC, might represent a morphological expression of a number of morbidities, nevertheless. The relationship of LVNC with connective tissue disorders such as SLE is unknown. We aim to present a case of a patient with SLE who recently showed features compatible with an atypical LVNC...
July 2014: Acta Reumatológica Portuguesa
L Manganaro, V Vinci, S Bernardo, P Sollazzo, M E Sergi, M Saldari, F Ventriglia, A Giancotti, G Rizzo, C Catalano
Congenital heart disease is one of the most frequent prenatal malformation representing an incidence of 5/1000 live births; moreover, it represents the first cause of death in the first year of life. There is a wide range of severity in congenital heart malformations from lesions which require no treatment such as small ventricular septal defects, to lesions which can only be treated with palliative surgery such as hypoplastic left heart syndrome. A good prenatal examination acquires great importance in order to formulate an early diagnosis and improve pregnancy management...
August 2014: Journal of Maternal-fetal & Neonatal Medicine
Ilaria Blangetti, Lorena Fenoglio, Carla Avallato, Marco Bertora, Claudio Novali, Flavio Peinetti, Alessandro Locatelli
Arterial thromboembolism in patients with an unknown source of embolization is associated with significant morbidity and mortality. Once the acute process has been treated, a search of the offending embolic source must be conducted to prevent additional episodes. The most common sources of peripheral embolism include intracardiac thrombi (>85%), thrombus within arterial aneurysm, thrombus overlying complex atherosclerotic plaques, and paradoxical embolization from deep venous thrombus. A strong association has been shown between protruding, noncalcified plaques>4 cm in the aorta detected by transesophageal echocardiography and the risk of embolism...
November 2013: Annals of Vascular Surgery
José Carlos Dorsa Vieira Pontes, João Jackson Duarte, Augusto Daige da Silva, Neimar Gardenal, Amaury Mont'Serrat Ávila Souza Dias, Ricardo Adala Benfatti, Guilherme Viotto Rodrigues da Silva, Amanda Ferreira Carli Benfatti
OBJECTIVE: This paper demonstrates the initial and pioneering experience implant of the Inovare prosthesis implant through transfemoral or iliac artery route. METHODS: Six patients underwent transcatheter aortic valve implantation. The access was femoral or iliac through which the delivery device, a latex balloon catheter with the crimped prosthesis, was inserted. Through the femoral introducer 24 Fr Gore® DrySeal sheath, an extra stiff guide wire with non-traumatic tip was positioned in the left ventricle by passing through the valve ring...
June 2013: Revista Brasileira de Cirurgia Cardiovascular
Sergio Mayor-Gómez, María Elena Erro, Fernando Olaz-Preciado, Mercedes Ciriza-Esandi, Jaime Gállego-Culleré
INTRODUCTION: Takotsubo syndrome is a transient stress cardiomyopathy associated with a distinctive left ventricular contraction pattern. It has been described as a cardioembolic source or as a consequence of stroke. Two patients are reported that illustrate the reciprocal relationship between Takotsubo syndrome and stroke and the physiopathological mechanisms implicated are analyzed. CASE REPORTS: Two women aged 70 and 78 years respectively are described. The first one was admitted with electro-cardiogram ST-segment elevation, slight troponin elevation and stroke symptoms...
October 16, 2012: Revista de Neurologia
Vanda Cristina Jorge, Ana Carolina Araújo, Ana Grilo, Carla Noronha, António Panarra, Nuno Riso, Manuel Vaz Riscado
Infective endocarditis can be associated with complex clinical presentations, sometimes with a difficult multi-disciplinary management. Actinobacillus actinomycetemcomitans belongs to the Haemophilus species, Actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens and Kingella species group, responsible for 5% to 10% of infective endocarditis in native heart valves. These organisms have slow fastidious growth pattern, often associated with negative cultures, and cause systemic embolism with abscess formation...
August 13, 2012: BMJ Case Reports
N Alessandri, F Tufano, M Petrassi, C Alessandri, L Lanzi, L Fusco, F Moscariello, C De Angelis, E Tomao
INTRODUCTION: The hysto-morfological composition of the ascending aorta wall gives to the vessel its characteristic elasticity/distensibility, which is deteriorated due to both physiological (age) and pathological events (hypertension, diabetes, dyslipidemia). This contributes to reduce the wall elasticity and to occurrence of cardiovascular events. MATERIALS AND METHODS: Thirty young healthy subjects (20 males, 10 females, age <30 yr), were subjected to different postural conditions with and without Lower Body Negative Pressure (LBNP) with conventional procedures, to simulate the microgravity conditions in space flight...
May 2010: European Review for Medical and Pharmacological Sciences
Gabriella Malfatto, Paola Cuoccio, Caterina Bizzi, Giovanna Branzi, Alessandra Villani, Francesco Della Rosa, Gianfranco Parati, Mario Facchini
BACKGROUND: Color-Doppler ecocardiography and cardiopulmonary stress test are pivotal in the evaluation of patients with heart failure. Besides determining systolic function through left ventricular ejection fraction (EF), color-Doppler ecocardiography evaluates the presence and degree of functional mitral regurgitation and the severity of diastolic dysfunction. Moreover, in addition to the aerobic capacity indicated by peak O2 consumption, other parameters of cardiopulmonary stress have proven useful for diagnostic purposes, such as the peak VE/VCO2 ratio or ventilatory efficiency...
June 2009: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
Luís Coentrão, Jorge Oliveira
SPE is a rare syndrome, although a frequent clinical presentation of several disorders, many times misdiagnosed in medical practice. It was described 30 years ago, almost always associated with intravenous drug abuse. Recent reports indicate that the epidemiology of patients with septic pulmonary embolism has changed over the past 30 years. We report a case of septic pulmonary embolism associated with tricuspid valve endocarditis. The patient had a personal history of intravenous drug abuse. The chief complaints were fever, anorexia and weight loss for 30 days...
November 2008: Revista Portuguesa de Pneumologia
Daniele C T Zaninelli, Ludimyla H F Meister, Rosana B Radominski, Victoria Z C Borba, Admar Moraes Souza, Cesar L Boguszewski
AIM: To study efficacy, safety and compliance of GH therapy for 4 years in 18 GH deficient (GHD) adults [12 women; mean age 50.5 yrs (25-66 yrs)]. METHODS: Clinical, biochemical and body composition (DXA) measurements were performed before and every year after GH therapy. Ecocardiography was performed at baseline and after 4 years. Dose of GH was 0.2 mg/day during the first year with subsequent titration to attain normal IGF-1 levels. RESULTS: There was a significant reduction of total body fat (mean 2...
July 2008: Arquivos Brasileiros de Endocrinologia e Metabologia
Uberto Da Col, Enrico Ramoni, Isidoro Di Bella, Temistocle Ragni
Left ventricular outflow tract (LVOT) pseudoaneurysm is a rare but potentially lethal complication, mainly after aortic root endocarditis or surgery. Usually it originates from a dehiscence in the mitral-aortic intervalvular fibrosa and it arises posteriorly to the aortic root. Due to these anatomical features, its imaging assessment is challenging and surgical repair requires complex procedures. An unusual case of LVOT pseudoaneurysm is described. It was detected by transthoracic ecocardiography 7 months after aortic root replacement for acute endocarditis...
January 2009: Cardiovascular and Interventional Radiology
Ernesto Tappainer, Vinicio Fiorani, Andrea Nocchi, Ermal Likaj, Sabjan Memishaj, Mario Zogno
BACKGROUND: Techniques of reduction aortoplasty are widely published in the literature with conflicting results. External support seems to be an important factor in preventing recurrence but, in some cases, this technique caused erosion of the aorta because of the wrinkles the prosthesis creates in the rear side of the aorta. CASE PRESENTATION: A 73 year old patient with aortic valve stenosis and borderline dilated ascending aorta had aortic valve replacement and simple wrapping without aortoplasty...
2007: Journal of Cardiothoracic Surgery
N Espinola-Zavaleta, E Alexanderson-Rosas, N Granados, M Elena Soto, M C Amigo
A significant correlation between autoimmune diseases and premature or accelerated coronary atherosclerosis has been found. The objectives of the study were: (a) to evaluate myocardial perfusion defects in patients with autoimmune diseases by contrast echocardiography and nuclear imaging; and (b) to evaluate the prevalence of alterations in subclinical myocardial perfusion defects in autoimmune diseases. Myocardial perfusion in 37 patients was evaluated by contrast echocardiography at rest and with dobutamine and with nuclear imaging...
2006: Lupus
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