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vancomycin induced thrombocytopenia

https://read.qxmd.com/read/38480595/linezolid-induced-thrombocytopenia-in-patients-with-renal-impairment-a-case-series-review-and-dose-advice
#1
JOURNAL ARTICLE
S R E Laarhuis, C H M Kerskes, M R Nijziel, R J A van Wensen, D J Touw
BACKGROUND AND OBJECTIVE: Oral linezolid is often used as alternative therapy for intravenous vancomycin. According to the current guidelines, no dose adjustment has to be made in case of renal impairment. Nevertheless, in our hospital we have seen several patients with renal impairment who developed linezolid-induced thrombocytopenia when linezolid was taken in the standard dose. In this case series and review we want to emphasize the necessity of reviewing the Dutch and international guidelines...
March 14, 2024: Drugs in R&D
https://read.qxmd.com/read/38021885/a-case-of-ceftaroline-associated-thrombocytopenia
#2
Ashwin Jagadish, Samra Hassan, Shahnawaz Notta, Venkata Vedantam, Neethu Vedantam
Ceftaroline is a fifth-generation cephalosporin that can be used for the treatment of serious infections caused by methicillin-resistant Staphylococcus aureus (MRSA). A rare adverse effect of ceftaroline therapy is thrombocytopenia. Our case involves a 45-year-old male with active intravenous drug usage who presented with persistent fever, lower back pain, and left elbow pain. His bloodcultures were found to be positive for MRSA. He was initially started on vancomycin; subsequently, the antibiotic was changed to daptomycin and ceftaroline, as vancomycin failed to clear the bacteremia...
October 2023: Curēus
https://read.qxmd.com/read/37753064/vancomycin-induced-thrombocytopenia-in-a-35-year-old-female-with-pneumonia-a-case-report
#3
Frederick Gyabaah, Bhavi Trivedi, Swathi Prakash, Cyrena Petersen, Jordan Ikeler, Fatma Dihowm
Vancomycin is one of the most empirically used antibiotics in severely ill patients in hospitalized settings. Vancomycin-induced thrombocytopenia (VITP) is a rare and potentially life-threatening complication that requires immediate recognition. Platelet destruction is largely immune-mediated and results in a precipitous drop in the platelet count over a short period of time. Most cases of VITP are drug-dependent, as discontinuation of the offending agent frequently results in a timely return to baseline to pre-exposure platelet levels...
September 2023: Curēus
https://read.qxmd.com/read/37674134/staphylococcus-epidermidis-induced-toxic-shock-syndrome-tss-secondary-to-influenza-infection
#4
JOURNAL ARTICLE
Charis Armeftis, Andreas Ioannou, Theodorakis Lazarou, Achilleas Giannopoulos, Efrosyni Dimitriadou, Kostantinos Makrides, Zoi Dorothea Pana
BACKGROUND: To date, few cases of TSS caused by coagulase negative (CoN) staphylococci have been reported in the literature. Recent data show that CoN staphylococci are capable of secreting a number of enterotoxins and cytotoxins, normally produced by S. aureus. Herewith, we describe a case of TSS caused by Staphylococcus epidermidis with a favorable outcome. CASE PRESENTATION: We report a case of a 46-year-old man who developed TSS from S. epidermidis. The patient was admitted for a 7-day history of general malaise and headache following a recent influenza infection and a 3-day history of vomiting, diarrhea, diffuse erythroderma, and fever...
September 6, 2023: BMC Infectious Diseases
https://read.qxmd.com/read/37640615/bleeding-complications-in-vancomycin-induced-thrombocytopenia-a-real-world-postmarketing-pharmacovigilance-analysis
#5
JOURNAL ARTICLE
Hui Yang, Ying Zhang, Xin Feng, Zhuoling An
PURPOSE: Vancomycin and linezolid are first-line drugs used for the prophylaxis and treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. Vancomycin is well known as the best alternative drug when linezolid-induced thrombocytopenia occurs. However, several cases with vancomycin-induced thrombocytopenia, especially with bleeding complications, have been reported recently, which has attracted attention. The objective of this study is to assess the potential relevance between vancomycin and bleeding complications in thrombocytopenia...
August 26, 2023: Clinical Therapeutics
https://read.qxmd.com/read/37581131/drug-induced-thrombocytopenia-a-case-involving-vancomycin
#6
Alexander Barnecet Pérez, Caleb A Niehues, Courtney M Hicks, Hemal Patel, Dayan Sanchez, David E Martin, Suporn Sukpraprut-Braaten
Drug-induced thrombocytopenia (DIT) is a rare adverse effect that occurs when administering various medications. The medications associated with this possible adverse effect include heparin, penicillin, furosemide, vancomycin, non-steroidal anti-inflammatory drugs, ranitidine, and many others. DIT causes a rapid decrease in platelet counts after drug administration and typically resolves once the offending agent has been discontinued. The induced thrombocytopenia increases the bleeding risk and possibility of adverse effects throughout a hospital course...
July 2023: Curēus
https://read.qxmd.com/read/37351249/immune-thrombocytopenia-a-rare-adverse-event-of-vancomycin-therapy
#7
Emeka S Obi, Devdat Lnu, Norense O Ehimwenma, Opeyemi Tobalesi, Winifred Iklaki, Faiza Arslan
Vancomycin, a glycopeptide antibiotic, is widely used for Gram-positive cocci or bacilli bacteria-induced serious infections. Although considered safe and effective, it still causes adverse events. Vancomycin-induced immune thrombocytopenia is a rarely reported adverse event, manifesting from asymptomatic thrombocytopenia to life-threatening bleeding. We underline a case of a 56-year-old male with a diabetic foot with an infected exudating purulent ulcer. He experienced a significant drop in platelet count after commencing vancomycin, and discontinuing vancomycin resulted in improved platelet count with positive vancomycin-induced anti-platelet antibodies...
May 2023: Curēus
https://read.qxmd.com/read/37218820/a-case-of-vancomycin-induced-severe-immune-thrombocytopenia
#8
Shivani Shah, Ryan Sweeney, Maitreyee Rai, Deep Shah
A male in his 60s presented with left lower extremity fractures following a vehicle accident. Hemoglobin, initially, was 12.4 mmol/L, and platelet count was 235 k/mcl. On day 11 of admission, his platelet count initially dropped to 99 k/mcl, and after recovery it rapidly decreased to 11 k/mcl on day 16 when the INR was 1.3 and aPTT was 32 s, and he continued to have a stable anemia throughout admission. There was no response in platelet count post-transfusion of four units of platelets. Hematology initially evaluated the patient for disseminated intravascular coagulation, heparin-induced thrombocytopenia (anti-PF4 antibody was 0...
April 24, 2023: Hematology Reports
https://read.qxmd.com/read/37121763/-a-case-of-thrombocytopenia-following-minocycline-administration
#9
JOURNAL ARTICLE
Shiori Tomita, Ryohei Fujii, Yusuke Imai, Norito Nishiyama, Masayuki Tanaka, Kazuki Uchitani, Tatsuya Muranaka
Drug-induced thrombocytopenia is associated with bleeding tendency and suggests the need for the immediate suspected drug withdrawal. Patients with drug-induced thrombocytopenia usually experience an acute drop in platelet (PLT) levels a week or two after starting a new medication. Thrombocytopenia has both immune and non-immune mechanisms. Minocycline (MINO)-induced thrombocytopenia is rare; thus, there are few studies of this condition. In the present study, intravenous administration of MINO led to thrombocytopenia...
2023: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://read.qxmd.com/read/36158232/linezolid-induced-pancytopenia-in-patients-using-dapagliflozin-a-case-series
#10
Meng Mei Li, Wen Cheng Shen, Yu Jin Li, Jun Teng
BACKGROUND: Linezolid is classed as oxazolidinone antibiotics which can be used to treat severe infections caused by vancomycin-resistant Enterococcus faecium, hospital-acquired pneumonia caused by Staphylococcus aureus, complicated skin, and uncomplicated skin structure infections (SSSIs) caused by methicillin-susceptible S. aureus or Streptococcus pyogenes, and community-acquired pneumonia caused by Streptococcus pneumoniae. However, many studies have suggested it can also cause thrombocytopenia and pancytopenia...
2022: Infection and Drug Resistance
https://read.qxmd.com/read/35989762/piperacillin-tazobactam-induced-rapid-severe-thrombocytopenia-without-known-exposure
#11
Amrit Bhaskarla, Mateusz D Gorecki, Masood Ghouse
Thrombocytopenia is one of the commonly encountered laboratory abnormalities in the inpatient setting. The process of excluding life-threatening causes can be daunting and may result in overlooking iatrogenic sources such as medications. Antibiotics are known culprits; however, there are limited reports of rapid and severe onset thrombocytopenia following piperacillin-tazobactam (TZP) that were frequently observed in critically ill or immunocompromised patients with previous exposure to the antibiotic. This case describes a patient being treated for a soft tissue infection with vancomycin and TZP...
July 2022: Curēus
https://read.qxmd.com/read/35812544/furosemide-induced-thrombotic-thrombocytopenic-purpura-a-report-of-a-rare-case
#12
Taruna Chandok, Zaheer A Qureshi, Laura Yapor, Misbahuddin Khaja
Drug-induced immune thrombocytopenia (DITP) refers to drug-dependent, antibody-mediated platelet destruction. Although several drugs have been implicated as the cause of DITP, the most commonly encountered are heparin, sulfonamides, quinine, vancomycin, and beta-lactam antibiotics. However, furosemide has been rarely reported as the cause of thrombocytopenia. We present a unique case of furosemide-induced thrombotic thrombocytopenia in a 64-year-old female referred by her primary care provider for low platelets, rash, and bleeding...
June 2022: Curēus
https://read.qxmd.com/read/35755077/severe-thrombocytopenia-caused-by-vancomycin-in-the-intensive-care-unit-a-case-report
#13
Xiao-Xiao Li, Guan-Ru Wang, Chao Li, Na He, Peng Yao, Yin-Chu Cheng, Chu-Hui Wang, Qing-Gang Ge, Min Yi, Zong-Yu Wang, Lu-Wen Shi, Rong-Sheng Zhao
Thrombocytopenia can cause substantial morbidity and mortality in critically ill patients. There are multiple etiology factors and various mechanisms associated with thrombocytopenia, of which drug-induced thrombocytopenia (DITP) deserves attention. Herein, we describe a case of severe thrombocytopenia during intensive care unit (ICU) hospitalization that was likely to be associated with vancomycin. By revealing the process of identifying this case of DITP and reviewing relevant clinical studies, a risk alert of vancomycin-related severe hematotoxicity should be considered...
2022: Frontiers in Medicine
https://read.qxmd.com/read/35727490/linezolid-vs-vancomycin-in-induced-thrombocytopenia
#14
JOURNAL ARTICLE
Dimah Al-Harbi, Abdulrahman Alturaiki, Ayshah Alshngeetee, Haya Aldabas, Layla AlBreacan, Renad Aljohani, Eid Hussein Alshahrani, Abdullah Althemery, Laila Carolina Abu Esba
INTRODUCTION: Linezolid and vancomycin have an important place among therapeutic antimicrobial options for multidrug-resistant gram-positive infections. Thrombocytopenia is an adverse effect reported with both and can lead to treatment interruption. Our objective was to compare the incidence of thrombocytopenia in patients receiving linezolid or vancomycin and to identify risk factors associated with thrombocytopenia. METHODS: This was a retrospective observational cohort study that involved patients who received linezolid (intravenously or orally) or vancomycin (intravenously) at a tertiary care hospital, between January 2016 and October 2019, for a minimum of 5 days and in whom platelet values were measured during treatment...
August 2022: Infectious Diseases and Therapy
https://read.qxmd.com/read/35464559/a-rare-case-of-vancomycin-induced-immune-thrombocytopenia
#15
Maha Hameed, Sultan Alamri, Sami Almustanyir
Vancomycin-induced immune thrombocytopenia (ITP) is a rare type of drug-induced immune thrombocytopenia (DITP) that can lead to life-threatening consequences as a result of its use. We herein report a case of a 74-year-old male with a history of diabetes mellitus type II, Alzheimer's disease, and stroke who presented to the ICU with sepsis. The patient was on heparin for 20 days prior to presentation, with platelet levels at the time within normal limits as per his baseline. Following the introduction of vancomycin to his clinical regimen in the treatment of sepsis, the patient developed a significant drop in platelet count from 400 x10³/mm³ to 70 x10³/mm³...
March 2022: Curēus
https://read.qxmd.com/read/35312093/effects-of-linezolid-on-the-haematological-system-in-very-low-birth-weight-infants-a-single-centre-retrospective-study
#16
JOURNAL ARTICLE
Xinghe Bu, Jianguo Zhou
WHAT IS KNOWN AND OBJECTIVE: Linezolid, as a substitute for vancomycin, has been used in treating methicillin-resistant Gram-positive bacterial infections in very low birth weight (VLBW) infants. However, when linezolid induces thrombocytopenia in adults, its side effects in VLBW infants are concerning. This study aimed to investigate the effect of linezolid on haematologic profiles in this specific vulnerable population. METHODS: VLBW infants treated with linezolid from January, 2017, to July, 2021, were retrospectively analysed compared with vancomycin as controls...
August 2022: Journal of Clinical Pharmacy and Therapeutics
https://read.qxmd.com/read/35079574/re-exposure-causing-rapid-onset-of-vancomycin-induced-thrombocytopenia
#17
Brent Boodhai, Aarti Maharaj, Carmina Aybar Rodriguez, Yu Shia Lin
Vancomycin is used for the treatment of gram-positive infections. The increasing prevalence of methicillin-resistant Staphylococcus aureus since the 1980 s has led to a significant increase in the clinical utility of vancomycin in the United States. The diagnosis of vancomycin induced thrombocytopenia (VIT) poses a challenge since it requires the exclusion of other etiologies of thrombocytopenia, such as infectious or immunologic diseases and alternative drugs. Physicians should be aware that VIT is a rare but important complication of IV vancomycin therapy and failure to recognize this diagnosis may lead to a delay in discontinuation of vancomycin and serious complications...
2022: IDCases
https://read.qxmd.com/read/34558345/piperacillin-tazobactam-induced-immune-thrombocytopenia-a-case-report
#18
JOURNAL ARTICLE
Shangwe Kiliaki
Drug-induced immune thrombocytopenia is an isolated thrombocytopenia caused by accelerated platelet destruction from drug-dependent, platelet-reactive antibodies. Heparin-induced thrombocytopenia is the most common drug-induced immune thrombocytopenia. Common implicated antibiotics for drug-induced immune thrombocytopenia include ceftriaxone, trimethoprim-sulfamethoxazole, vancomycin, and penicillin. The platelet nadir can be less than 20 × 10 (9)/L and typically occurs within 1 to 2 weeks of exposure to the inciting drug...
September 24, 2021: Journal of Pharmacy Practice
https://read.qxmd.com/read/34536040/intraperitoneal-vancomycin-induced-immune-thrombocytopenia
#19
Ahmet Murt, Tuba Ozkan Tekin, Suleyman Sami Guzel, Sercan Olcar, Ayse Salihoglu, Muveddet Rezzan Ataman
Vancomycin is one of the drugs used in the peritonitis treatment regimen of peritoneal dialysis patients. Intraperitoneal route is generally preferred to provide rapid elimination of infective agents. Systemic toxicities of certain drugs after intraperitoneal administration are not very clear. The same also applies to vancomycin, although it has a considerable amount of systemic absorption after intraperitoneal administration. We herein report a case of severe thrombocytopenia, which was seen during the treatment of a peritonitis attack in a peritoneal dialysis patient...
January 2022: Seminars in Dialysis
https://read.qxmd.com/read/34489258/rare-complication-of-ceftriaxone-therapy-drug-induced-thrombocytopenia-ditp
#20
JOURNAL ARTICLE
Aishwarya Sharma, Devendranath Mannuru, Abhishek Matta, Amit Kaushal
A 62-year-old woman with a history of end-stage renal disease on haemodialysis, essential hypertension and type 2 diabetes mellitus was diagnosed with sepsis and placed on 600 mg oral linezolid every 12 hours and 1 g intravenous ceftriaxone every 24 hours. Blood cultures grew Streptococcus dysgalactiae , and she was switched to intravenous ceftriaxone 2 g daily. Platelet counts slowly trended down after starting ceftriaxone reaching 5 K/μL on day 12 of treatment. Ceftriaxone was discontinued and heparin-induced thrombocytopaenia was ruled out...
September 6, 2021: BMJ Case Reports
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