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https://www.readbyqxmd.com/read/27919300/a-randomised-placebo-controlled-trial-of-transcranial-pulsed-electromagnetic-fields-in-patients-with-multiple-chemical-sensitivity
#1
Marie Thi Dao Tran, Sine Skovbjerg, Lars Arendt-Nielsen, Karl Bang Christensen, Jesper Elberling
OBJECTIVE: To evaluate the efficacy of transcranially applied pulsed electromagnetic fields (PEMF) on functional impairments and symptom severity in multiple chemical sensitivity (MCS) patients. METHODS: The study was conducted as a nationwide trial in Denmark using a randomised, parallel-group, double-blind and placebo-controlled design. Sample size was estimated at 40 participants. Eligibility criteria were age 18-75 years and fulfilment of the MCS case criteria...
December 6, 2016: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27901476/the-change-of-hcn1-hcn2-mrna-expression-in-peripheral-nerve-after-chronic-constriction-injury-induced-neuropathy-followed-by-pulsed-electromagnetic-field-therapy
#2
Hui Liu, Jun Zhou, Lianbing Gu, Yunxia Zuo
Neuropathic pain is usually defined as a chronic pain state caused by peripheral or central nerve injury as a result of acute damage or systemic diseases. It remains a difficult disease to treat. Recent studies showed that the frequency of action potentials in nociceptive afferents is affected by the activity of hyperpolarization-activated cyclic nucleotide-gated cation channels (HCN) family. In the current study, we used a neuropathy rat model induced by chronic constriction injury (CCI) of sciatic nerve to evaluate the change of expression of HCN1/HCN2 mRNA in peripheral nerve and spinal cord...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27886102/an-investigation-on-the-effect-of-extremely-low-frequency-pulsed-electromagnetic-fields-on-human-electrocardiograms-ecgs
#3
Qiang Fang, Seedahmed S Mahmoud, Jiayong Yan, Hui Li
For this investigation, we studied the effects of extremely low frequency pulse electromagnetic fields (ELF-PEMF) on the human cardiac signal. Electrocardiograms (ECGs) of 22 healthy volunteers before and after a short duration of ELF-PEMF exposure were recorded. The experiment was conducted under single-blind conditions. The root mean square (RMS) value of the recorded data was considered as comparison criteria. We also measured and analysed four important ECG time intervals before and after ELF-PEMF exposure...
November 23, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27874284/effects-of-extremely-low-frequency-pulsed-electromagnetic-fields-elf-pemfs-on-glioblastoma-cells-u87
#4
Zeinab Akbarnejad, Hossein Eskandary, Cristian Vergallo, Seyed Noureddin Nematollahi-Mahani, Luciana Dini, Fatemeh Darvishzadeh-Mahani, Meysam Ahmadi
The impact of extremely low-frequency pulsed electromagnetic fields (ELF-PEMFs) at various frequencies and amplitudes was investigated on cell cycle, apoptosis and viability of the Glioblastoma Multiforme (GBM) cell line (U87), in vitro. The GBM is a malignant brain tumor with high mortality in humans and poorly responsive to the most common type of cancer treatments, such as surgery, chemotherapy and radiation therapy. U87 cells with five experimental groups (I-V) were exposed to various ELF-PEMFs for 2, 4 and 24 h, as follows: (I) no exposure, control; (II) 50 Hz 100 ± 15 G; (III) 100 Hz 100 ± 15 G; (IV) 10 Hz 50 ± 10 G; (V) 50 Hz 50 ± 10 G...
November 22, 2016: Electromagnetic Biology and Medicine
https://www.readbyqxmd.com/read/27859405/effects-of-bmp9-and-pulsed-electromagnetic-fields-on-the-proliferation-and-osteogenic-differentiation-of-human-periodontal-ligament-stem-cells
#5
Tingting Wang, Pei Wang, Zhizhong Cao, Xingxing Wang, Dalin Wang, Yaxian Shen, Da Jing, Erping Luo, Weizhong Tang
Periodontal ligament stem cells (PDLSCs) have been confirmed to have self-renewal capacity and multidifferentiation potential and are good candidates for periodontal tissue regeneration. Pulsed electromagnetic field (PEMF) has been demonstrated to promote osteogenesis in non-union fractures, partly by regulating mesenchymal stem cells or osteoblast activity. However, there is no report about the osteo-inductive effect of PEMF stimulation on human PDLSCs (hPDLSCs). Thus, we tested the hypothesis that PEMF biophysical stimulation alone has an influence on the proliferation and osteogenic differentiation of hPDLSCs...
January 2017: Bioelectromagnetics
https://www.readbyqxmd.com/read/27856256/pulsed-electromagnetic-field-inhibits-rankl-dependent-osteoclastic-differentiation-in-raw264-7-cells-through-the-ca-2-calcineurin-nfatc1-signaling-pathway
#6
Jie Zhang, Haixia Xu, Zhongyu Han, Ping Chen, Qiang Yu, Yutian Lei, Zongze Li, Ming Zhao, Jing Tian
Pulsed electromagnetic field (PEMF) has been reported to improve bone healing in osteoporosis patients. However, the precise mechanism has remained largely unknown. This study aimed to investigate the effects of PEMF on nuclear factor κB ligand (RANKL)-dependent osteoclastic differentiation and the Ca(2+)-calcineurin-NFATc1 signaling pathway in RAW264.7 cells in vitro. Treating RAW264.7 cells with RANKL for 4 days induced osteoclastic differentiation in vitro, and the formation of multinucleated osteoclasts, bone resorption-pit formation, tartrate-resistant acid phosphatase (TRAP) activity and the protein levels of cathepsin K, TRAP, Nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1) and matrix metalloproteinase 9 (MMP-9) were significantly decreased...
November 14, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27856169/pulsed-electromagnetic-field-ameliorates-cartilage-degeneration-by-inhibiting-mitogen-activated-protein-kinases-in-a-rat-model-of-osteoarthritis
#7
Jun Zhou, Yuan Liao, Haitao Xie, Ying Liao, Huifang Liu, Yahua Zeng, Neng Li
OBJECTIVES: We assessed the effects of pulsed electromagnetic field (PEMF) on cartilage degeneration, and expression of mitogen-activated protein kinases (MAPKs) and matrix metalloproteinases (MMPs), in an experimental rat model of osteoarthritis induced by anterior cruciate ligament transection (ACLT). DESIGN: Experimental. SETTING: University animal laboratory. PARTICIPANTS: 30 male Sprague-Dawley rats. MAIN OUTCOME MEASURES: We performed histological examination, enzyme-linked immunosorbent assay, quantitative real-time polymerase chain reaction, to assess cartilage degeneration, urine C-terminal cross-linking telopeptide of type II collagen (CTX-II), and mRNA expression of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (c-Jun), p38, and MMPs...
October 27, 2016: Physical Therapy in Sport
https://www.readbyqxmd.com/read/27793904/pulsed-electromagnetic-field-with-temozolomide-can-elicit-an-epigenetic-pro-apoptotic-effect-on-glioblastoma-t98g-cells
#8
Francesca Pasi, Lorenzo Fassina, Maria Evelina Mognaschi, Giuseppe Lupo, Franco Corbella, Rosanna Nano, Enrica Capelli
Treatment with pulsed electromagnetic fields (PEMFs) is emerging as an interesting therapeutic option for patients with cancer. The literature has demonstrated that low-frequency/low-energy electromagnetic fields do not cause predictable effects on DNA; however, they can epigenetically act on gene expression. The aim of the present work was to study a possible epigenetic effect of a PEMF, mediated by miRNAs, on a human glioblastoma cell line (T98G). We tested a PEMF (maximum magnetic induction, 2 mT; frequency, 75 Hz) that has been demonstrated to induce autophagy in glioblastoma cells...
November 2016: Anticancer Research
https://www.readbyqxmd.com/read/27790871/combined-effect-of-pulsed-electromagnetic-field-and-sound-wave-on-in-vitro-and-in-vivo-neural-differentiation-of-human-mesenchymal-stem-cells
#9
Yun-Kyong Choi, Enerelt Urnukhsaikhan, Hee-Hoon Yoon, Young-Kwon Seo, Hyunjin Cho, Jong-Seob Jung, Soo-Chan Kim, Jung-Keug Park
Biophysical wave stimulus has been used as an effective tool to promote cellular maturation and differentiation in the construction of engineered tissue. Pulsed electromagnetic fields (PEMFs) and sound waves have been selected as effective stimuli that can promote neural differentiation. The aim of this study was to investigate the synergistic effect of PEMFs and sound waves on the neural differentiation potential in vitro and in vivo using human bone marrow mesenchymal stem cells (hBM-MSCs). In vitro, neural-related genes in hBM-MSCs were accelerated by the combined exposure to both waves more than by individual exposure to PEMFs or sound waves...
October 28, 2016: Biotechnology Progress
https://www.readbyqxmd.com/read/27780890/novel-protective-effects-of-pulsed-electromagnetic-field-ischemia-reperfusion-injury-rats
#10
Fenfen Ma, Wenwen Li, Xinghui Li, Ba Hieu Tran, Rinkiko Suguro, Ruijuan Guan, Cuilan Hou, Huijuan Wang, Aijie Zhang, Yichun Zhu, YiZhun Zhu
Extracorporeal pulsed electromagnetic field (PEMF) has shown the ability to regenerate tissue by promoting cell proliferation. In the present study, we investigated for the first time whether PEMF treatment could improve the myocardial ischaemia/reperfusion (I/R) injury and uncovered its underlying mechanisms.In our study, we demonstrated for the first time that extracorporeal PEMF has a novel effect on myocardial I/R injury. The number and function of circulating endothelial progenitor cells (EPCs) were increased in PEMF treating rats...
December 2016: Bioscience Reports
https://www.readbyqxmd.com/read/27761795/neuroprotective-effect-of-low-frequency-pulsed-electromagnetic-fields-in-ischemic-stroke
#11
Enerelt Urnukhsaikhan, Tsogbadrakh Mishig-Ochir, Soo-Chan Kim, Jung-Keug Park, Young-Kwon Seo
Low frequency-pulsed electromagnetic fields (LF-PEMFs) affect many biological processes; however, the fundamental mechanisms responsible for these effects remain unclear. Our study aimed to investigate the effect of LF-PEMFs on neuroprotection after ischemic stroke. C57B6 mice were exposed to LF-PEMF (F = 60 Hz, Bm = 10 mT) after photothrombotic occlusion. We measured the BDNF/TrkB/Akt signaling pathway, pro-apoptotic and pro-survival protein and gene expressions, and the expression of inflammatory mediators and performed behavioral tests in both LF-PEMF-treated and untreated ischemic stroke mice...
October 19, 2016: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/27748048/mechanisms-and-therapeutic-effectiveness-of-pulsed-electromagnetic-field-therapy-in-oncology
#12
REVIEW
Maria Vadalà, Julio Cesar Morales-Medina, Annamaria Vallelunga, Beniamino Palmieri, Carmen Laurino, Tommaso Iannitti
Cancer is one of the most common causes of death worldwide. Available treatments are associated with numerous side effects and only a low percentage of patients achieve complete remission. Therefore, there is a strong need for new therapeutic strategies. In this regard, pulsed electromagnetic field (PEMF) therapy presents several potential advantages including non-invasiveness, safety, lack of toxicity for non-cancerous cells, and the possibility of being combined with other available therapies. Indeed, PEMF stimulation has already been used in the context of various cancer types including skin, breast, prostate, hepatocellular, lung, ovarian, pancreatic, bladder, thyroid, and colon cancer in vitro and in vivo...
November 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27711964/effects-of-combined-treatment-with-ibandronate-and-pulsed-electromagnetic-field-on-ovariectomy-induced-osteoporosis-in-rats
#13
Jun Zhou, Yuan Liao, Haitao Xie, Ying Liao, Yahua Zeng, Neng Li, Guanghua Sun, Qi Wu, Guijuan Zhou
Ibandronate (IBN) and pulsed electromagnetic field (PEMF) have each shown positive effects for treating osteoporosis, but no study has evaluated the relative effects of these treatments combined. This study investigated the effects of IBN + PEMF on bone turnover, mineral density, microarchitecture, and biomechanical properties in an ovariectomized (OVX) rat model of osteoporosis. Fifty 3-month-old rats were randomly apportioned to receive a sham-operation (n = 10), or ovariectomy (n = 40). The latter group was equally divided as the model (OVX control) or to receive IBN, PEMF, or IBN + PEMF...
October 6, 2016: Bioelectromagnetics
https://www.readbyqxmd.com/read/27686373/regenerate-bone-stimulation-following-limb-lengthening-a-meta-analysis
#14
Julio J Jauregui, Anthony V Ventimiglia, Preston W Grieco, David B Frumberg, John E Herzenberg
BACKGROUND: Limb lengthening with external fixation is performed to treat patients with leg length discrepancy or short stature. Although the procedure has a high rate of success, one potential drawback from limb lengthening is the amount of time spent in the fixation device while regenerate bone consolidates. Although some studies have assessed different treatment modalities, there has not been a study that has systematically evaluated whether low intensity pulsed ultrasound (LIPUS) or pulsed electromagnetic fields (PEMF) have significant effects on regenerate bone growth...
September 29, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27685089/effects-of-low-frequency-pulsed-electromagnetic-fields-on-plateau-frostbite-healing-in-rats
#15
Mingke Jiao, Lin Lou, Lin Jiao, Jie Hu, Peng Zhang, Zhongming Wang, Wenjuan Xu, Xiliang Geng, Hongping Song
Plateau frostbite (PF) treatments have remained a clinical challenge because this condition injures tissues in deep layers and affected tissues exhibit unique pathological characteristics. For instance, low-frequency pulsed electromagnetic field (PEMF) can affect tissue restoration and penetrate tissues. Therefore, the effect of PEMF on PF healing should be investigated. This study aimed to evaluate the effects of low-frequency PEMF on PF healing systematically. Ninety-six Sprague-Dawley rats were randomly and equally divided into three groups: normal control, partial thickness plateau frostbite (PTPF), and PTPF with low-frequency PEMF exposure (PTPF + PEMF)...
September 29, 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27639248/pulsed-electromagnetic-field-exposure-reduces-hypoxia-and-inflammation-damage-in-neuron-like-and-microglial-cells
#16
Fabrizio Vincenzi, Annalisa Ravani, Silvia Pasquini, Stefania Merighi, Stefania Gessi, Stefania Setti, Ruggero Cadossi, Pier Andrea Borea, Katia Varani
In the present study, the effect of low-frequency, low-energy pulsed electromagnetic fields (PEMFs) has been investigated by using different cell lines derived from neuron-like cells and microglial cells. In particular, the primary aim was to evaluate the effect of PEMF exposure in inflammation- and hypoxia-induced injury in two different neuronal cell models, the human neuroblastoma-derived SH-SY5Y cells and rat pheochromocytoma PC12 cells and in N9 microglial cells. In neuron-like cells, live/dead and apoptosis assays were performed in hypoxia conditions from 2 to 48 h...
September 17, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27634482/pulsed-electromagnetic-field-assisted-in-vitro-electroporation-a-pilot-study
#17
Vitalij Novickij, Audrius Grainys, Eglė Lastauskienė, Rūta Kananavičiūtė, Dovilė Pamedytytė, Lilija Kalėdienė, Jurij Novickij, Damijan Miklavčič
Electroporation is a phenomenon occurring due to exposure of cells to Pulsed Electric Fields (PEF) which leads to increase of membrane permeability. Electroporation is used in medicine, biotechnology, and food processing. Recently, as an alternative to electroporation by PEF, Pulsed ElectroMagnetic Fields (PEMF) application causing similar biological effects was suggested. Since induced electric field in PEMF however is 2-3 magnitudes lower than in PEF electroporation, the membrane permeabilization mechanism remains hypothetical...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27629357/low-frequency-pulsed-electromagnetic-field-promotes-c2c12-myoblasts-proliferation-via-activation-of-mapk-erk-pathway
#18
Haixia Xu, Jie Zhang, Yutian Lei, Zhongyu Han, Dongming Rong, Qiang Yu, Ming Zhao, Jing Tian
Low frequency pulsed electromagnetic field (PEMF) has been shown to affect the activity of various cell types and promote them proliferation. However, its effect on skeletal muscle cells remains to be determined. In our study, we confirmed that PEMF (100 Hz, 1 mT) could promote C2C12 myoblasts proliferation by using Cell Counting Kit-8 (CCK-8) and 5-Ethynyl-2'-deoxyuridine (EdU) assays, yet hardly any distinction was found in the rate of cell apoptosis between PEMF and control groups by flow cytometry (Annexin V-FITC/PI double staining method)...
October 7, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27622883/pulsed-electromagnetic-fields-stimulate-osteogenic-differentiation-and-maturation-of-osteoblasts-by-upregulating-the-expression-of-bmprii-localized-at-the-base-of-primary-cilium
#19
Yan-Fang Xie, Wen-Gui Shi, Jian Zhou, Yu-Hai Gao, Shao-Feng Li, Qing-Qing Fang, Ming-Gang Wang, Hui-Ping Ma, Ju-Fang Wang, Cory J Xian, Ke-Ming Chen
Pulsed electromagnetic fields (PEMFs) have been considered as a potential candidate for the prevention and treatment of osteoporosis, however, the mechanism of its action is still elusive. We have previously reported that 50Hz 0.6mT PEMFs stimulate osteoblastic differentiation and mineralization in a primary cilium- dependent manner, but did not know the reason. In the current study, we found that the PEMFs promoted osteogenic differentiation and maturation of rat calvarial osteoblasts (ROBs) by activating bone morphogenetic protein BMP-Smad1/5/8 signaling on the condition that primary cilia were normal...
September 10, 2016: Bone
https://www.readbyqxmd.com/read/27555216/pulsed-electromagnetic-fields-promote-osteogenesis-and-osseointegration-of-porous-titanium-implants-in-bone-defect-repair-through-a-wnt-%C3%AE-catenin-signaling-associated-mechanism
#20
Da Jing, Mingming Zhai, Shichao Tong, Fei Xu, Jing Cai, Guanghao Shen, Yan Wu, Xiaokang Li, Kangning Xie, Juan Liu, Qiaoling Xu, Erping Luo
Treatment of osseous defects remains a formidable clinical challenge. Porous titanium alloys (pTi) have been emerging as ideal endosseous implants due to the excellent biocompatibility and structural properties, whereas inadequate osseointegration poses risks for unreliable long-term implant stability. Substantial evidence indicates that pulsed electromagnetic fields (PEMF), as a safe noninvasive method, inhibit osteopenia/osteoporosis experimentally and clinically. We herein investigated the efficiency and potential mechanisms of PEMF on osteogenesis and osseointegration of pTi in vitro and in vivo...
2016: Scientific Reports
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