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https://www.readbyqxmd.com/read/29775839/veterinary-applications-of-pulsed-electromagnetic-field-therapy
#1
REVIEW
James S Gaynor, Sean Hagberg, Blake T Gurfein
Pulsed electromagnetic field (PEMF) therapy can non-invasively treat a variety of pathologies by delivering electric and magnetic fields to tissues via inductive coils. The electromagnetic fields generated by these devices have been found to affect a variety of biological processes and basic science understanding of the underlying mechanisms of action of PEMF treatment has accelerated in the last 10 years. Accumulating clinical evidence supports the use of PEMF therapy in both animals and humans for specific clinical indications including bone healing, wound healing, osteoarthritis and inflammation, and treatment of post-operative pain and edema...
May 7, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29775452/the-effects-of-a-pulsed-electromagnetic-field-on-the-proliferation-and-osteogenic-differentiation-of-human-adipose-derived-stem-cells
#2
Yukun Yin, Ping Chen, Qiang Yu, Yan Peng, ZeHao Zhu, Jing Tian
BACKGROUND A low frequency pulsed electromagnetic field (PEMF) has been confirmed to play an important role in promoting the osteogenic differentiation of human bone marrow stem cells (BMSCs). Adipose-derived stem cells (ASCs) possess some attractive characteristics for clinical application compared to BMSCs, such as abundant stem cells from lipoaspirates, faster growth, less discomfort and morbidity during surgery. ASCs can become adipocytes, osteoblasts, chondrocytes, myocytes, neurocytes, and other cell types...
May 18, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29752033/effectiveness-of-monopolar-dielectric-transmission-of-pulsed-electromagnetic-fields-for-multiple-sclerosis-related-pain-a-pilot-study
#3
A Hochsprung, S Escudero-Uribe, A J Ibáñez-Vera, G Izquierdo-Ayuso
INTRODUCTION: Pain is highly prevalent in patients with multiple sclerosis (MS); it is chronic in 50% of cases and is classified as nociceptive, neuropathic, or mixed-type. Pain affects quality of life, sleep, and the activities of daily living. Electrotherapy is an interesting alternative or complementary treatment in the management of pain in MS, with new innovations constantly appearing. MATERIAL AND METHODS: This study evaluates the effectiveness of treatment with monopolar dielectric transmission of pulsed electromagnetic fields (PEMF) for pain associated with MS...
May 8, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/29749519/pulsed-electromagnetic-fields-inhibit-osteoclast-differentiation-in-raw264-7-macrophages-via-suppression-of-the-protein-kinase-b-mammalian-target-of-rapamycin-signaling-pathway
#4
Yutian Lei, Jinyu Su, Haixia Xu, Qiang Yu, Ming Zhao, Jing Tian
When bone resorption, aided by the activity of osteoclasts, exceeds bone formation induced by osteoblasts, bone metabolism loses equilibration, which results in the development of bone diseases, including osteoporosis. Pulsed electromagnetic fields (PEMFs) are known to be involved in various biological processes, including cell proliferation, differentiation and apoptosis. However, the exact mechanism of action of osteoclasts remains poorly understood. In the present study, the effects of PEMFs on osteoclast differentiation and associated signaling pathways were systematically investigated in RAW264...
May 9, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29709070/pulsed-electromagnetic-field-therapy-in-the-treatment-of-pain-and-other-symptoms-in-fibromyalgia-a-randomized-controlled-study
#5
Juhani Multanen, Arja Häkkinen, Pauli Heikkinen, Hannu Kautiainen, Sirpa Mustalampi, Jari Ylinen
Low-energy pulsed electromagnetic field (PEMF) therapy has been suggested as a promising therapy to increase microcirculation, which is of great concern in patients with fibromyalgia. This study evaluated the effectiveness of PEMF therapy on the treatment of fibromyalgia. A group of 108 women with fibromyalgia were allocated to a 12-week treatment period with an active Bio-Electro-Magnetic-Energy-Regulation (BEMER) device and a similar treatment period with an inactive device. Each patient received active and sham treatments in a random order...
April 30, 2018: Bioelectromagnetics
https://www.readbyqxmd.com/read/29694967/underlying-signaling-pathways-and-therapeutic-applications-of-pulsed-electromagnetic-fields-in-bone-repair
#6
Jie Yuan, Fei Xin, Wenxue Jiang
Pulsed electromagnetic field (PEMF) stimulation, as a prospective, noninvasive, and safe physical therapy strategy to accelerate bone repair has received tremendous attention in recent decades. Physical PEMF stimulation initiates the signaling cascades, which effectively promote osteogenesis and angiogenesis in an orchestrated spatiotemporal manner and ultimately enhance the self-repair capability of bone tissues. Considerable research progresses have been made in exploring the underlying cellular and subcellular mechanisms of PEMF promotion effect in bone repair...
April 20, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29658660/-effect-of-low-frequency-low-intensity-electromagnetic-fields-on-maturation-and-mineralization-of-rat-skull-osteoblasts-i-in-vitro-i
#7
Baoying Zhu, Jian Zhou, Yuhai Gao, Wengui Shi, Zhenlong Wei, Wenyuan Li, Yuanyuan Wang, Keming Chen
<b>Objective:</b> To compare the effects of 50 Hz 1.8 mT sinusoidal magnetic field (SEMF) and 50 Hz 0.6 mT pulsed electromagnetic field(PEMF) on the maturation and mineralization of rat calvaria osteoblasts. <b>Methods:</b> Primary cultured rat calvarial osteoblasts were divided into 3 groups:blank control group, SEMF group and PEMF group. The rats in SEMT and PEMT groups were treated with 50 Hz 1.8 mT SEMF or 50 Hz 0.6 mT PEMF for 90 min/d, respectively. Western blotting and Real-time RT-PCR were used to detect the protein and mRNA expressions of Collagen-1, bone morphogenetic protein 2 (BMP-2), osterix (OSX) and Runt-associated transcription factor 2(Runx-2)...
May 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/29584700/can-pulsed-electromagnetic-fields-trigger-on-demand-drug-release-from-high-tm-magnetoliposomes
#8
Martina Nardoni, Elena Della Valle, Micaela Liberti, Michela Relucenti, Maria Antonietta Casadei, Patrizia Paolicelli, Francesca Apollonio, Stefania Petralito
Recently, magnetic nanoparticles (MNPs) have been used to trigger drug release from magnetoliposomes through a magneto-nanomechanical approach, where the mechanical actuation of the MNPs is used to enhance the membrane permeability. This result can be effectively achieved with low intensity non-thermal alternating magnetic field (AMF), which, however, found rare clinic application. Therefore, a different modality of generating non-thermal magnetic fields has now been investigated. Specifically, the ability of the intermittent signals generated by non-thermal pulsed electromagnetic fields (PEMFS) were used to verify if, once applied to high-transition temperature magnetoliposomes (high-Tm MLs), they could be able to efficiently trigger the release of a hydrophilic model drug...
March 27, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29584629/co-culture-with-human-osteoblasts-and-exposure-to-extremely-low-frequency-pulsed-electromagnetic-fields-improve-osteogenic-differentiation-of-human-adipose-derived-mesenchymal-stem-cells
#9
Sabrina Ehnert, Martijn van Griensven, Marina Unger, Hanna Scheffler, Karsten Falldorf, Anne-Kristin Fentz, Claudine Seeliger, Steffen Schröter, Andreas K Nussler, Elizabeth R Balmayor
Human adipose-derived mesenchymal stem cells (Ad-MSCs) have been proposed as suitable option for cell-based therapies to support bone regeneration. In the bone environment, Ad-MSCs will receive stimuli from resident cells that may favor their osteogenic differentiation. There is recent evidence that this process can be further improved by extremely low frequency pulsed electromagnetic fields (ELF-PEMFs). Thus, the project aimed at (i) investigating whether co-culture conditions of human osteoblasts (OBs) and Ad-MSCs have an impact on their proliferation and osteogenic differentiation; (ii) whether this effect can be further improved by repetitive exposure to two specific ELF-PEMFs (16 and 26 Hz); (iii) and the effect of these ELF-PEMFs on human osteoclasts (OCs)...
March 27, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29572540/pulsed-electromagnetic-fields-increase-osteogenetic-commitment-of-mscs-via-the-mtor-pathway-in-tnf-%C3%AE-mediated-inflammatory-conditions-an-in-vitro-study
#10
Letizia Ferroni, Chiara Gardin, Oleg Dolkart, Moshe Salai, Shlomo Barak, Adriano Piattelli, Hadar Amir-Barak, Barbara Zavan
Pulsed electromagnetic fields (PEMFs) have been considered a potential treatment modality for fracture healing, however, the mechanism of their action remains unclear. Mammalian target of rapamycin (mTOR) signaling may affect osteoblast proliferation and differentiation. This study aimed to assess the osteogenic differentiation of mesenchymal stem cells (MSCs) under PEMF stimulation and the potential involvement of mTOR signaling pathway in this process. PEMFs were generated by a novel miniaturized electromagnetic device...
March 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29523929/pulsed-electromagnetic-fields-preserve-bone-architecture-and-mechanical-properties-and-stimulate-porous-implant-osseointegration-by-promoting-bone-anabolism-in-type-1-diabetic-rabbits
#11
J Cai, W Li, T Sun, X Li, E Luo, D Jing
The effects of exogenous pulsed electromagnetic field (PEMF) stimulation on T1DM-associated osteopathy were investigated in alloxan-treated rabbits. We found that PEMF improved bone architecture, mechanical properties, and porous titanium (pTi) osseointegration by promoting bone anabolism through a canonical Wnt/β-catenin signaling-associated mechanism, and revealed the clinical potential of PEMF stimulation for the treatment of T1DM-associated bone complications. INTRODUCTION: Type 1 diabetes mellitus (T1DM) is associated with deteriorated bone architecture and impaired osseous healing potential; nonetheless, effective methods for resisting T1DM-associated osteopenia/osteoporosis and promoting bone defect/fracture healing are still lacking...
May 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29492540/pulsed-electromagnetic-field-pemf-mitigates-high-intracranial-pressure-icp-induced-microvascular-shunting-mvs-in-rats
#12
Denis E Bragin, Olga A Bragina, Sean Hagberg, Edwin M Nemoto
OBJECTIVE: High-frequency pulsed electromagnetic field (PEMF) stimulation is an emerging noninvasive therapy that we have shown increases cerebral blood flow (CBF) and tissue oxygenation in the healthy rat brain. In this work, we tested the effect of PEMF on the brain at high intracranial pressure (ICP). We previously showed that high ICP in rats caused a transition from capillary (CAP) to non-nutritive microvascular shunt (MVS) flow, tissue hypoxia and increased blood brain barrier (BBB) permeability...
2018: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/29451219/low-frequency-pulsed-electromagnetic-field-pretreated-bone-marrow-derived-mesenchymal-stem-cells-promote-the-regeneration-of-crush-injured-rat-mental-nerve
#13
NaRi Seo, Sung-Ho Lee, Kyung Won Ju, JaeMan Woo, BongJu Kim, SoungMin Kim, Jeong Won Jahng, Jong-Ho Lee
Bone marrow-derived mesenchymal stem cells (BMSCs) have been shown to promote the regeneration of injured peripheral nerves. Pulsed electromagnetic field (PEMF) reportedly promotes the proliferation and neuronal differentiation of BMSCs. Low-frequency PEMF can induce the neuronal differentiation of BMSCs in the absence of nerve growth factors. This study was designed to investigate the effects of low-frequency PEMF pretreatment on the proliferation and function of BMSCs and the effects of low-frequency PEMF pre-treated BMSCs on the regeneration of injured peripheral nerve using in vitro and in vivo experiments...
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29437635/pulsed-electromagnetic-field-stimulation-may-improve-fusion-rates-in-cervical-arthrodesis-in-high-risk-populations
#14
D Coric, D E Bullard, V V Patel, J T Ryaby, B L Atkinson, D He, R D Guyer
OBJECTIVES: Pulsed electromagnetic field (PEMF) stimulation was evaluated after anterior cervical discectomy and fusion (ACDF) procedures in a randomized, controlled clinical study performed for United States Food and Drug Administration (FDA) approval. PEMF significantly increased fusion rates at six months, but 12-month fusion outcomes for subjects at elevated risk for pseudoarthrosis were not thoroughly reported. The objective of the current study was to evaluate the effect of PEMF treatment on subjects at increased risk for pseudoarthrosis after ACDF procedures...
February 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29356996/the-application-of-pulsed-electromagnetic-fields-pemfs-for-bone-fracture-repair-past-and-perspective-findings
#15
REVIEW
C Daish, R Blanchard, K Fox, P Pivonka, E Pirogova
Bone fractures are one of the most commonly occurring injuries of the musculoskeletal system. A highly complex physiological process, fracture healing has been studied extensively. Data from in vivo, in vitro and clinical studies, have shown pulsed electromagnetic fields (PEMFs) to be highly influential in the fracture repair process. Whilst the underlying mechanisms acting to either inhibit or advance the physiological processes are yet to be defined conclusively, several non-invasive point of use devices have been developed for the clinical treatment of fractures...
April 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29324868/effects-of-pulsed-electromagnetic-field-pemf-on-the-tensile-biomechanical-properties-of-diabetic-wounds-at-different-phases-of-healing
#16
Harry M C Choi, Alex K K Cheing, Gabriel Y F Ng, Gladys L Y Cheing
The present study investigated the effects of pulsed electromagnetic field (PEMF) on the tensile biomechanical properties of diabetic wounds at different phases of healing. Two intensities of PEMF were adopted for comparison. We randomly assigned 111 10-week-old male streptozotocin-induced diabetic Sprague-Dawley rats to two PEMF groups and a sham control group. Six-millimetre biopsy punched full thickness wounds were made on the lateral side of their hindlimbs. The PEMF groups received active PEMF delivered at 25 Hz with intensity of either 2 mT or 10 mT daily, while the sham group was handled in a similar way except they were not exposed to PEMF...
2018: PloS One
https://www.readbyqxmd.com/read/29310504/the-effect-of-electromagnetic-fields-on-post-operative-pain-and-locomotor-recovery-in-dogs-with-acute-severe-thoracolumbar-intervertebral-disc-extrusion-a-randomized-placebo-controlled-prospective-clinical-trial
#17
Natalia Zidan, Joe Fenn, Emily Griffith, Peter J Early, Chris L Mariani, Karen R Muñana, Julien Guevar, Natasha J Olby
Spinal cord injury (SCI) attributed to acute intervertebral disc extrusions (IVDEs) is common in dogs and is treated by surgical decompression. Dogs with sensorimotor complete injuries have an incomplete recovery. Pulsed electromagnetic fields (PEMFs) reduce post-operative pain through anti-inflammatory effects and there is growing evidence for neuroprotective effects. This randomized, controlled clinical trial evaluated the effect of PEMF on post-operative pain and neurological recovery in dogs with surgically treated sensorimotor complete SCI attributed to acute IVDE...
April 2, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29251361/pulsed-electromagnetic-field-improves-subchondral-bone-microstructure-in-knee-osteoarthritis-rats-through-a-wnt-%C3%AE-catenin-signaling-associated-mechanism
#18
Xiaotian Yang, Hongchen He, Qiang Gao, Chengqi He
Pulsed electromagnetic field (PEMF) is often used for management of osteoarthritis (OA). The aim of the study was to determine whether PEMF can successfully improve subchondral bone microstructure through a Wnt/β-catenin signaling-associated pathway in rats with knee OA induced by low-dose monosodium iodoacetate (MIA). Seventy-two 12-week-old male Sprague-Dawley rats were randomly assigned to three groups: OA (n = 24), PEMF (n = 24), and Control (n = 24). OA was induced (OA and PEMF groups) by injecting 0...
February 2018: Bioelectromagnetics
https://www.readbyqxmd.com/read/29229438/pulsed-electromagnetic-fields-pemf-attenuate-changes-in-vertebral-bone-mass-architecture-and-strength-in-ovariectomized-mice
#19
Tao Lei, Zhuowen Liang, Feijiang Li, Chi Tang, Kangning Xie, Pan Wang, Xu Dong, Shuai Shan, Maogang Jiang, Qiaoling Xu, Erping Luo, Guanghao Shen
Pulsed electromagnetic fields (PEMF) has been investigated as a noninvasive alternative method to prevent bone loss for postmenopausal osteoporosis (OP), and the bone tissue involved in these studies are usually long bones such as femur and tibia in OP patients or rat models. However, few studies have investigated the effects of PEMF on the vertebral bone in mice with OP. This study aimed to investigate whether PEMF preserve lumbar vertebral bone mass, microarchitecture and strength in ovariectomized (OVX) mouse model of OP and its associated mechanisms...
March 2018: Bone
https://www.readbyqxmd.com/read/29184281/high-intensity-laser-therapy-versus-pulsed-electromagnetic-field-in-the-treatment-of-primary-dysmenorrhea
#20
Ali Abd El-Monsif Thabet, Ahmed Mohamed Elsodany, Kadrya H Battecha, Mansour Abdullah Alshehri, Bassem Refaat
[Purpose] To determine the efficacy of high intensity laser therapy (HILT) versus pulsed electromagnetic field (PEMF) in the treatment of primary dysmenorrhea. [Subjects and Methods] This was a randomized clinical trial that included 52 girls diagnosed with primary dysmenorrhea and who were assigned randomly into two groups of equal numbers. The treatment was three sessions every cycle for three consecutive cycles where group (A) included those participants treated with HILT 15 min/session and group (B) those who were treated with PEMF 30 min/session...
October 2017: Journal of Physical Therapy Science
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