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https://www.readbyqxmd.com/read/29776712/erratum-to-a-new-hdv-mouse-model-identifies-mitochondrial-antiviral-signaling-protein-mavs-as-a-key-player-in-ifn-%C3%AE-induction-j-hepatol-67-2017-669-679
#1
Lester Suárez-Amarán, Carla Usai, Marianna Di Scala, Cristina Godoy, Yi Ni, Mirja Hommel, Laura Palomo, Víctor Segura, Cristina Olagüe, Africa Vales, Alicia Ruiz-Ripa, Maria Buti, Eduardo Salido, Jesús Prieto, Stephan Urban, Francisco Rodríguez-Frias, Rafael Aldabe, Gloria González-Aseguinolaza
No abstract text is available yet for this article.
May 15, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29769705/possible-role-of-the-nipah-virus-v-protein-in-the-regulation-of-the-interferon-beta-induction-by-interacting-with-ubx-domain-containing-protein1
#2
Shotaro Uchida, Ryo Horie, Hiroki Sato, Chieko Kai, Misako Yoneda
Nipah virus (NiV) is a highly pathogenic paramyxovirus that causes lethal encephalitis in humans. We previously reported that the V protein, one of the three accessory proteins encoded by the P gene, is one of the key determinants of the pathogenesis of NiV in a hamster infection model. Satterfield B.A. et al. have also revealed that V protein is required for the pathogenicity of henipavirus in a ferret infection model. However, the complete functions of NiV V have not been clarified. In this study, we identified UBX domain-containing protein 1 (UBXN1), a negative regulator of RIG-I-like receptor signaling, as a host protein that interacts with NiV V...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29769346/porcine-deltacoronavirus-accessory-protein-ns6-antagonizes-ifn-%C3%AE-production-by-interfering-with-the-binding-of-rig-i-mda5-to-double-stranded-rna
#3
Puxian Fang, Liurong Fang, Jie Ren, Yingying Hong, Xiaorong Liu, Yunyang Zhao, Dang Wang, Guiqing Peng, Shaobo Xiao
Porcine deltacoronavirus (PDCoV) has recently emerged as an enteric pathogen that can cause serious vomiting and diarrhea in suckling piglets. The first outbreak of PDCoV occurred in the United States in 2014 and was followed by reports of PDCoV in South Korea, China, Thailand, Lao people's Democratic Republic, and Vietnam, leading to economic losses for pig farms and posing considerable threat to the swine industry worldwide. Our previous studies have shown that PDCoV encodes three accessory proteins, NS6, NS7, and NS7a, but the functions of these proteins in viral replication, pathogenesis, and immune regulation remain unclear...
May 16, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29769269/trim29-negatively-regulates-the-type-i-ifn-production-in-response-to-rna-virus
#4
Junji Xing, Ao Zhang, Laurie J Minze, Xian Chang Li, Zhiqiang Zhang
The innate immunity is critically important in protection against virus infections, and in the case of RNA viral infections, the signaling mechanisms that initiate robust protective innate immunity without triggering autoimmune inflammation remain incompletely defined. In this study, we found the E3 ligase TRIM29 was specifically expressed in poly I:C-stimulated human myeloid dendritic cells. The induced TRIM29 played a negative role in type I IFN production in response to poly I:C or dsRNA virus reovirus infection...
May 16, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29747672/two-ways-to-improve-myoelectric-control-for-a-transhumeral-amputee-after-targeted-muscle-reinnervation-a-case-study
#5
Yang Xu, Dingguo Zhang, Yang Wang, Juntao Feng, Wendong Xu
BACKGROUND: Myoelectric control of multifunctional prostheses is challenging for individuals with high-level amputations due to insufficient surface electromyography (sEMG) signals. A surgical technique called targeted muscle reinnervation (TMR) has achieved impressive improvements in myoelectric control by providing more sEMG control signals. In this case, some channels of sEMG signals are coupled after TMR, which limits the performance of conventional amplitude-based control for upper-limb prostheses...
May 10, 2018: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29746593/peroxisomes-support-human-herpesvirus-8-latency-by-stabilizing-the-viral-oncogenic-protein-vflip-via-the-mavs-traf-complex
#6
Young Bong Choi, Yeeun Choi, Edward William Harhaj
Human herpesvirus 8 (HHV-8) is causally related to human malignancies. HHV-8 latent viral FLICE-inhibitory protein (vFLIP) is a viral oncoprotein that is linked to pathogenesis, but how its expression is regulated is largely unknown. In an attempt to understand the role of the mitochondrial antiviral signaling (MAVS) adaptor in HHV-8 infection, we discovered that vFLIP expression was post-translationally up-regulated by the MAVS signaling complex on peroxisomes. Furthermore, we demonstrated that vFLIP could be targeted to the peroxisomes, where it was oncogenically active, in a PEX19-dependent manner...
May 10, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29743353/trim21-promotes-innate-immune-response-to-rna-viral-infection-through-lys27-linked-polyubiquitination-of-mavs
#7
Binbin Xue, Huiyi Li, Mengmeng Guo, Jingjing Wang, Yan Xu, Xuan Zou, Rilin Deng, Guangdi Li, Haizhen Zhu
Human innate immunity responds to viral infection by activating the production of interferons (IFNs) and proinflammatory cytokines. The mitochondrial adaptor molecule MAVS plays a critical role in innate immune response to viral infection. In this study, we show that TRIM21 interacts with MAVS to positively regulate innate immunity. Under viral infection, TRIM21 is upregulated through the IFN/JAK/STAT signaling pathway. Knockdown of TRIM21 dramatically impairs innate immune response to viral infection. Moreover, TRIM21 interacts with MAVS and catalyzes the K27-linked polyubiquitination of MAVS, thereby promoting the recruitment of TBK1 to MAVS...
May 9, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29739942/molecular-mechanism-of-influenza-a-ns1-mediated-trim25-recognition-and-inhibition
#8
Marios G Koliopoulos, Mathilde Lethier, Annemarthe G van der Veen, Kevin Haubrich, Janosch Hennig, Eva Kowalinski, Rebecca V Stevens, Stephen R Martin, Caetano Reis E Sousa, Stephen Cusack, Katrin Rittinger
RIG-I is a viral RNA sensor that induces the production of type I interferon (IFN) in response to infection with a variety of viruses. Modification of RIG-I with K63-linked poly-ubiquitin chains, synthesised by TRIM25, is crucial for activation of the RIG-I/MAVS signalling pathway. TRIM25 activity is targeted by influenza A virus non-structural protein 1 (NS1) to suppress IFN production and prevent an efficient host immune response. Here we present structures of the human TRIM25 coiled-coil-PRYSPRY module and of complexes between the TRIM25 coiled-coil domain and NS1...
May 8, 2018: Nature Communications
https://www.readbyqxmd.com/read/29735197/effect-of-parkinson-disease-on-emotion-perception-using-the-persian-affective-voices-test
#9
Arezoo Saffarian, Yunes Amiri Shavaki, Gholam Ali Shahidi, Zahra Jafari
BACKGROUND AND OBJECTIVES: Emotion perception plays a major role in proper communication with people in different social interactions. Nonverbal affect bursts can be used to evaluate vocal emotion perception. The present study was a preliminary step to establishing the psychometric properties of the Persian version of the Montreal Affective Voices (MAV) test, as well as to investigate the effect of Parkinson disease (PD) on vocal emotion perception. METHODS: The short, emotional sound made by pronouncing the vowel "a" in Persian was recorded by 22 actors and actresses to develop the Persian version of the MAV, the Persian Affective Voices (PAV), for emotions of happiness, sadness, pleasure, pain, anger, disgust, fear, surprise, and neutrality...
May 4, 2018: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29734366/induction-of-otud1-by-rna-viruses-potently-inhibits-innate-immune-responses-by-promoting-degradation-of-the-mavs-traf3-traf6-signalosome
#10
Liting Zhang, Jin Liu, Liping Qian, Qian Feng, Xiaofang Wang, Yukang Yuan, Yibo Zuo, Qiao Cheng, Ying Miao, Tingting Guo, Xiaofeng Zheng, Hui Zheng
During RNA virus infection, the adaptor protein MAVS recruits TRAF3 and TRAF6 to form a signalosome, which is critical to induce the production of type I interferons (IFNs) and proinflammatory cytokines. While activation of the MAVS/TRAF3/TRAF6 signalosome is well studied, the negative regulation of the signalosome remains largely unknown. Here we report that RNA viruses specifically promote the deubiquitinase OTUD1 expression by NF-κB-dependent mechanisms at the early stage of viral infection. Furthermore, OTUD1 upregulates protein levels of intracellular Smurf1 by removing Smurf1 ubiquitination...
May 7, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29727627/differential-interferon-system-gene-expression-profiles-in-susceptible-and-resistant-gynogenetic-clones-of-gibel-carp-challenged-with-herpesvirus-cahv
#11
Cheng-Yan Mou, Yang Wang, Qi-Ya Zhang, Fan-Xiang Gao, Zhi Li, Jin-Feng Tong, Li Zhou, Jian-Fang Gui
Interferon (IFN) system plays a vital role in the first line of defense against viruses. In this study, we first identified multiple transcripts of 15 IFN system genes, including PRRs (TLR2, TLR3, RIG-I, and LGP2), PRR-mediated IFN signal pathway (MyD88, MITA, and MAVS), IFN regulatory factors (IRF1, IRF3, IRF7, and IRF9), IFNs (IFNφ1 and IFNφ3), and ISGs (Mx and viperin), and one transcript of TLR9 in de novo transcriptome assembly data of gibel carp head-kidney. Multiple nucleotide alignments and phylogenetic analysis of common region showed that the transcripts of every of the 15 IFN system genes were classified into two homologs with distinctly divergent sequences, indicating that hexaploid gibel carp may be an allopolyploid...
May 1, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29717007/selective-packaging-in-murine-coronavirus-promotes-virulence-by-limiting-type-i-interferon-responses
#12
Jeremiah Athmer, Anthony R Fehr, Matthew E Grunewald, Wen Qu, D Lori Wheeler, Kevin W Graepel, Rudragouda Channappanavar, Aimee Sekine, Dana Saud Aldabeeb, Michael Gale, Mark R Denison, Stanley Perlman
Selective packaging is a mechanism used by multiple virus families to specifically incorporate genomic RNA (gRNA) into virions and exclude other types of RNA. Lineage A betacoronaviruses incorporate a 95-bp stem-loop structure, the packaging signal (PS), into the nsp15 locus of ORF1b that is both necessary and sufficient for the packaging of RNAs. However, unlike other viral PSs, where mutations generally resulted in viral replication defects, mutation of the coronavirus (CoV) PS results in large increases in subgenomic RNA packaging with minimal effects on gRNA packaging in vitro and on viral titers...
May 1, 2018: MBio
https://www.readbyqxmd.com/read/29686682/targeting-cytosolic-nucleic-acid-sensing-pathways-for-cancer-immunotherapies
#13
REVIEW
Sandra Iurescia, Daniela Fioretti, Monica Rinaldi
The innate immune system provides the first line of defense against pathogen infection though also influences pathways involved in cancer immunosurveillance. The innate immune system relies on a limited set of germ line-encoded sensors termed pattern recognition receptors (PRRs), signaling proteins and immune response factors. Cytosolic receptors mediate recognition of danger damage-associated molecular patterns (DAMPs) signals. Once activated, these sensors trigger multiple signaling cascades, converging on the production of type I interferons and proinflammatory cytokines...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29679565/activation-of-tlr3-and-its-adaptor-ticam-1-increases-mir-21-levels-in-extracellular-vesicles-released-from-human-cells
#14
Yoshimi Fukushima, Masaaki Okamoto, Kana Ishikawa, Takahisa Kouwaki, Hirotake Tsukamoto, Hiroyuki Oshiumi
Pattern-recognition receptors (PRRs) recognizes viral RNAs and trigger the innate immune responses. Toll-like receptor 3 (TLR3), a PRR, recognizes viral double-stranded RNA (dsRNA) in endolysosomes, whereas cytoplasmic dsRNA is sensed by another PRR, MDA5. TLR3 and MDA5 utilize TICAM-1 and MAVS, respectively, to trigger the signal for inducing innate immune responses. Extracellular vesicles (EVs) include the exosomes and microvesicles; an accumulating body of evidence has shown that EVs delivers functional RNA, such as microRNAs (miRNAs), to other cells and thus mediate intercellular communications...
April 18, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29661811/murine-models-of-hepatitis-a-virus-infection
#15
Asuka Hirai-Yuki, Jason K Whitmire, Michael Joyce, D Lorne Tyrrell, Stanley M Lemon
Mechanistic analyses of hepatitis A virus (HAV)-induced pathogenesis have long been thwarted by the lack of tractable small animal models that recapitulate disease observed in humans. Several approaches have shown success, including infection of chimeric mice with human liver cells. Other recent studies show that HAV can replicate to high titer in mice lacking expression of the type I interferon (IFN) receptor (IFN-α/β receptor) or mitochondrial antiviral signaling (MAVS) protein. Mice deficient in the IFN receptor show critical features of type A hepatitis in humans when challenged with human HAV, including histological evidence of liver damage, leukocyte infiltration, and the release of liver enzymes into blood...
April 16, 2018: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/29626090/a-gtpase-activating-protein-binding-protein-g3bp1-antiviral-protein-relay-conveys-arteriosclerotic-wnt-signals-in-aortic-smooth-muscle-cells
#16
Bindu Ramachandran, John N Stabley, Su-Li Cheng, Abraham S Behrmann, Austin Gay, Li Li, Megan Mead, Julia Kozlitina, Andrew Lemoff, Hamid Mirzaei, Zhijian Chen, Dwight A Towler
In aortic vascular smooth muscle (VSM), the canonical Wnt receptor LRP6 inhibits protein arginine (Arg) methylation, a new component of noncanonical Wnt signaling that stimulates nuclear factor of activated T cells (viz., NFATc4). To better understand how methylation mediates these actions, mass spectrometry was performed on VSM cell extracts from control and LRP6-deficient mice. LRP6-dependent Arg methylation was regulated on > 500 proteins; only 21 exhibited increased monomethylation (MMA) with concomitant reductions in dimethylation...
April 6, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29609027/identification-characterization-and-expression-analysis-of-mavs-in-pelodiscus-sinensis-after-challenge-with-poly-i-c
#17
Haisheng Xu, Jing Zhao, Yiyi Zou, Binjie Lu, Hanxiang Chen, Wanrong Zhang, Yue Wu, Jinjin Yang
Pelodiscus sinensis, which is one of the important reptile species in the aquaculture industry in China, frequently suffers from serious infectious diseases caused by viruses. However, there is a lack of biological knowledge about its antiviral innate immunity. In this study, we identified and characterized the open reading frame (ORF) of PsMAVS cDNA in P. sinensis. It consisted of 2691 nucleotides encoding a protein of 896 amino acid residues, which were composed of an N-terminal CARD, a central proline-rich domain and a C-terminal TM domain...
March 30, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29604449/the-mechanisms-of-ag85a-dna-vaccine-activates-rna-sensors-through-new-signal-transduction
#18
Jingbo Zhai, Qiubo Wang, Yunfeng Gao, Ran Zhang, Shengjun Li, Bing Wei, Yong You, Xun Sun, Changlong Lu
Low immunogenicity is one of the major problems limiting the clinical use for DNA vaccines, which makes it impossible to obtain a strong protective immune response after vaccination. In order to explore whether Ag85A DNA vaccine could mount more efficiently protective immune response through new RNA sensor and its signal transduction pathway of antigen presentation we designed and synthesized Ag85A gene fragment containing multiple points mutations and transfected the gene fragment into the dendritic cell line (DC2...
March 28, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29600142/effect-of-microtrichia-on-the-interlocking-mechanism-in-the-asian-ladybeetle-harmonia-axyridis-coleoptera-coccinellidae
#19
Jiyu Sun, Chao Liu, Bharat Bhushan, Wei Wu, Jin Tong
The hindwings of beetles are folded under the elytra when they are at rest but are extended during flight, which can provide bioinspiration for the design of deployable micro air vehicles (MAVs). Beetle hindwings must be able to be both securely locked under the elytra and freely extended for flight, depending on the required action. To investigate the locking mechanism, this study used environmental scanning electron microscopy (ESEM) to examine the microstructures of the elytra, hindwings and abdomen of the Asian ladybeetle, Harmonia axyridis (Pallas, 1773)...
2018: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/29592874/decreased-a-to-i-rna-editing-as-a-source-of-keratinocytes-dsrna-in-psoriasis
#20
Lea Shallev, Eli Kopel, Ariel Feiglin, Gil S Leichner, Dror Avni, Yehezkel Sidi, Eli Eisenberg, Aviv Barzilai, Erez Y Levanon, Shoshana Greenberger
Recognition of dsRNA molecules activates the MDA5-MAVS pathway, and plays a critical role in stimulating type-I interferon responses in psoriasis. However, the source of the dsRNA accumulation in psoriatic keratinocytes remains largely unknown. A-to-I RNA editing is a common co- or post-transcriptional modification that diversifies adenosine in dsRNA, and leads to unwinding of dsRNA structures. Thus, impaired RNA editing activity can result in an increased load of endogenous dsRNAs. Here we provide a transcriptome wide analysis of RNA editing across dozens of psoriasis patients, and demonstrate a global editing reduction in psoriatic lesions...
March 28, 2018: RNA
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